{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:45Z","timestamp":1792101645669,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660702"],"award-info":[{"award-number":["81660702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460650"],"award-info":[{"award-number":["81460650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11011-018-0328-x","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T20:52:16Z","timestamp":1538513536000},"page":"93-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress"],"prefix":"10.1007","volume":"34","author":[{"given":"Ji-Xiao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ling","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Qiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Cheng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"328_CR1","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1038\/npp.2009.75","volume":"34","author":"M Boldrini","year":"2009","unstructured":"Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, John Mann J, Arango V (2009) Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacol 34:2376\u20132389. https:\/\/doi.org\/10.1038\/npp.2009.75","journal-title":"Neuropsychopharmacol"},{"key":"328_CR2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.lfs.2017.09.023","volume":"190","author":"OD Can","year":"2017","unstructured":"Can OD, Turan N, Demir Ozkay U, Ozturk Y (2017) Antidepressant-like effect of gallic acid in mice: dual involvement of serotonergic and catecholaminergic systems. Life Sci 190:110\u2013117. https:\/\/doi.org\/10.1016\/j.lfs.2017.09.023","journal-title":"Life Sci"},{"key":"328_CR3","doi-asserted-by":"publisher","first-page":"5434","DOI":"10.1038\/s41598-018-23685-9","volume":"8","author":"B Cao","year":"2018","unstructured":"Cao B, Luo Q, Fu Y, du L, Qiu T, Yang X, Chen X, Chen Q, Soares JC, Cho RY, Zhang XY, Qiu H (2018) Predicting individual responses to the electroconvulsive therapy with hippocampal subfield volumes in major depression disorder. Sci Rep 8:5434. https:\/\/doi.org\/10.1038\/s41598-018-23685-9","journal-title":"Sci Rep"},{"key":"328_CR4","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1007\/s11064-018-2530-y","volume":"43","author":"Y Chandrasekhar","year":"2018","unstructured":"Chandrasekhar Y, Phani Kumar G, Ramya EM, Anilakumar KR (2018) Gallic acid protects 6-OHDA induced neurotoxicity by attenuating oxidative stress in human dopaminergic cell line. Neurochem Res 43:1150\u20131160. https:\/\/doi.org\/10.1007\/s11064-018-2530-y","journal-title":"Neurochem Res"},{"key":"328_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1472-8206.2012.01040.x","volume":"27","author":"R Chhillar","year":"2013","unstructured":"Chhillar R, Dhingra D (2013) Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress. Fundam Clin Pharmacol 27:409\u2013418. https:\/\/doi.org\/10.1111\/j.1472-8206.2012.01040.x","journal-title":"Fundam Clin Pharmacol"},{"key":"328_CR6","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1089\/ars.2012.5142","volume":"19","author":"G Corona","year":"2013","unstructured":"Corona G, Vauzour D, Hercelin J, Williams CM, Spencer JP (2013) Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression\/activation. Antioxid Redox Signal 19:1676\u20131689. https:\/\/doi.org\/10.1089\/ars.2012.5142","journal-title":"Antioxid Redox Signal"},{"key":"328_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","volume":"62","author":"DJ David","year":"2009","unstructured":"David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R (2009) Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression. Neuron 62:479\u2013493. https:\/\/doi.org\/10.1016\/j.neuron.2009.04.017","journal-title":"Neuron"},{"key":"328_CR8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.brainresbull.2009.03.009","volume":"79","author":"LR Drzyzga","year":"2009","unstructured":"Drzyzga LR, Marcinowska A, Obuchowicz E (2009) Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies. Brain Res Bull 79:248\u2013257. https:\/\/doi.org\/10.1016\/j.brainresbull.2009.03.009","journal-title":"Brain Res Bull"},{"key":"328_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tins.2011.11.004","volume":"35","author":"RS Duman","year":"2012","unstructured":"Duman RS, Voleti B (2012) Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci 35:47\u201356. https:\/\/doi.org\/10.1016\/j.tins.2011.11.004","journal-title":"Trends Neurosci"},{"key":"328_CR10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","volume":"24","author":"EJ Huang","year":"2001","unstructured":"Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677\u2013736. https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.677","journal-title":"Annu Rev Neurosci"},{"key":"328_CR11","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.1523\/JNEUROSCI.6078-08.2009","volume":"29","author":"H Jourdi","year":"2009","unstructured":"Jourdi H, Hsu YT, Zhou M, Qin Q, Bi X, Baudry M (2009) Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation. J Neurosci 29:8688\u20138697. https:\/\/doi.org\/10.1523\/JNEUROSCI.6078-08.2009","journal-title":"J Neurosci"},{"key":"328_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jad.2017.03.034","volume":"215","author":"A Kerling","year":"2017","unstructured":"Kerling A, K\u00fcck M, Tegtbur U, Grams L, Weber-Spickschen S, Hanke A, Stubbs B, Kahl KG (2017) Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder. J Affect Disord 215:152\u2013155. https:\/\/doi.org\/10.1016\/j.jad.2017.03.034","journal-title":"J Affect Disord"},{"key":"328_CR13","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","volume":"289","author":"RC Kessler","year":"2003","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS, National Comorbidity Survey Replication (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). Jama 289:3095\u20133105. https:\/\/doi.org\/10.1001\/jama.289.23.3095","journal-title":"Jama"},{"key":"328_CR14","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fpsyt.2017.00308","volume":"8","author":"T Kishi","year":"2017","unstructured":"Kishi T, Yoshimura R, Ikuta T, Iwata N (2017) Brain-derived neurotrophic factor and major depressive disorder: evidence from Meta-analyses. Front Psych 8:308. https:\/\/doi.org\/10.3389\/fpsyt.2017.00308","journal-title":"Front Psych"},{"key":"328_CR15","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuroscience.2011.12.015","volume":"203","author":"W Li","year":"2012","unstructured":"Li W, Keifer J (2012) Rapid enrichment of presynaptic protein in boutons undergoing classical conditioning is mediated by brain-derived neurotrophic factor. Neuroscience 203:50\u201358. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.12.015","journal-title":"Neuroscience"},{"key":"328_CR16","doi-asserted-by":"publisher","unstructured":"Lim DA, Alvarez-Buylla A (2016) The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis. Cold Spring Harb Perspect Biol 8 https:\/\/doi.org\/10.1101\/cshperspect.a018820","DOI":"10.1101\/cshperspect.a018820"},{"key":"328_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/srep16024","volume":"5","author":"XL Liu","year":"2015","unstructured":"Liu XL, Luo L, Mu RH, Liu BB, Geng D, Liu Q, Yi LT (2015) Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. Sci Rep 5:16024. https:\/\/doi.org\/10.1038\/srep16024","journal-title":"Sci Rep"},{"key":"328_CR18","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.tins.2004.08.001","volume":"27","author":"MP Mattson","year":"2004","unstructured":"Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589\u2013594. https:\/\/doi.org\/10.1016\/j.tins.2004.08.001","journal-title":"Trends Neurosci"},{"key":"328_CR19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1139\/jpn.0905","volume":"34","author":"MC McKinnon","year":"2009","unstructured":"McKinnon MC, Yucel K, Nazarov A, MacQueen GM (2009) A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psych Neurosci: JPN 34:41\u201354","journal-title":"J Psych Neurosci: JPN"},{"key":"328_CR20","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s00213-016-4357-z","volume":"233","author":"RH Mu","year":"2016","unstructured":"Mu RH, Fang XY, Wang SS, Li CF, Chen SM, Chen XM, Liu Q, Li YC, Yi LT (2016) Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus. Psychopharmacology 233:3211\u20133221. https:\/\/doi.org\/10.1007\/s00213-016-4357-z","journal-title":"Psychopharmacology"},{"key":"328_CR21","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3109\/10717544.2012.738437","volume":"19","author":"K Nagpal","year":"2012","unstructured":"Nagpal K, Singh SK, Mishra DN (2012) Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for improved antioxidant and antidepressant-like activity. Drug Deliv 19:378\u2013391. https:\/\/doi.org\/10.3109\/10717544.2012.738437","journal-title":"Drug Deliv"},{"key":"328_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/hipo.22670","volume":"27","author":"MV Olesen","year":"2017","unstructured":"Olesen MV, Wortwein G, Folke J, Pakkenberg B (2017) Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats. Hippocampus 27:52\u201360. https:\/\/doi.org\/10.1002\/hipo.22670","journal-title":"Hippocampus"},{"key":"328_CR23","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1017\/S1461145714000534","volume":"17","author":"SW Park","year":"2014","unstructured":"Park SW, Lee JG, Seo MK, Lee CH, Cho HY, Lee BJ, Seol W, Kim YH (2014) Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. Int J Neuropsychopharmacol 17:1831\u20131846. https:\/\/doi.org\/10.1017\/S1461145714000534","journal-title":"Int J Neuropsychopharmacol"},{"key":"328_CR24","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Archives Internationales de Pharmacodynamie et de Therapie 229:327\u2013336","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"328_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.brainresbull.2017.08.009","volume":"134","author":"Y Ren","year":"2017","unstructured":"Ren Y, Wang JL, Zhang X, Wang H, Ye Y, Song L, Wang YJ, Tu MJ, Wang WW, Yang L, Jiang B (2017) Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain Res Bull 134:211\u2013219. https:\/\/doi.org\/10.1016\/j.brainresbull.2017.08.009","journal-title":"Brain Res Bull"},{"key":"328_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/13651501.2017.1297834","volume":"21","author":"JK Rybakowski","year":"2017","unstructured":"Rybakowski JK, Permoda-Osip A, Bartkowska-Sniatkowska A (2017) Ketamine augmentation rapidly improves depression scores in inpatients with treatment-resistant bipolar depression. Int J Psychiatry Clin Pract 21:99\u2013103. https:\/\/doi.org\/10.1080\/13651501.2017.1297834","journal-title":"Int J Psychiatry Clin Pract"},{"key":"328_CR27","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.1083328","volume":"301","author":"L Santarelli","year":"2003","unstructured":"Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805\u2013809. https:\/\/doi.org\/10.1126\/science.1083328","journal-title":"Science"},{"key":"328_CR28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000368575","volume":"61","author":"DR Seib","year":"2015","unstructured":"Seib DR, Martin-Villalba A (2015) Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review. Gerontology 61:327\u2013335. https:\/\/doi.org\/10.1159\/000368575","journal-title":"Gerontology"},{"key":"328_CR29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.21307\/ane-2017-031","volume":"76","author":"MY Stepanichev","year":"2016","unstructured":"Stepanichev MY, Tishkina AO, R. Novikova M, Levshina IP, V. Freiman S, V. Onufriev M, Levchenko OA, A. Lazareva N, V. Gulyaeva N (2016) Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiol Exp 76:324\u2013333","journal-title":"Acta Neurobiol Exp"},{"key":"328_CR30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0269881117742666","volume":"32","author":"VN Thakare","year":"2018","unstructured":"Thakare VN, Patil RR, Oswal RJ, Dhakane VD, Aswar MK, Patel BM (2018) Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. J Psychopharmacol 32:223\u2013235. https:\/\/doi.org\/10.1177\/0269881117742666","journal-title":"J Psychopharmacol"},{"key":"328_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/hipo.20156","volume":"16","author":"JL Warner-Schmidt","year":"2006","unstructured":"Warner-Schmidt JL, Duman RS (2006) Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 16:239\u2013249. https:\/\/doi.org\/10.1002\/hipo.20156","journal-title":"Hippocampus"},{"key":"328_CR32","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/BF00187257","volume":"93","author":"P Willner","year":"1987","unstructured":"Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93:358\u2013364","journal-title":"Psychopharmacology"},{"key":"328_CR33","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1503\/jpn.130169","volume":"39","author":"LT Yi","year":"2014","unstructured":"Yi LT, Li J, Liu BB, Luo L, Liu Q, Geng D (2014) BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice. J Psych Neurosci: JPN 39:348\u2013359","journal-title":"J Psych Neurosci: JPN"},{"key":"328_CR34","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s11011-015-9710-0","volume":"30","author":"LT Yi","year":"2015","unstructured":"Yi LT, Luo L, Wu YJ, Liu BB, Liu XL, Geng D, Liu Q (2015) Circadian variations in behaviors, BDNF and cell proliferation in depressive mice. Metab Brain Dis 30:1495\u20131503. https:\/\/doi.org\/10.1007\/s11011-015-9710-0","journal-title":"Metab Brain Dis"},{"key":"328_CR35","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/JCP.0000000000000352","volume":"35","author":"JJ Yu","year":"2015","unstructured":"Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL (2015) Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol 35:406\u2013410. https:\/\/doi.org\/10.1097\/JCP.0000000000000352","journal-title":"J Clin Psychopharmacol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-018-0328-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:39:17Z","timestamp":1761097157000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-018-0328-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["328"],"URL":"https:\/\/doi.org\/10.1007\/s11011-018-0328-x","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]},"assertion":[{"value":"9 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}