{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:34:35Z","timestamp":1789497275018,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T00:00:00Z","timestamp":1544832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11011-018-0368-2","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T23:53:04Z","timestamp":1544831584000},"page":"431-442","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK- NF-\u03baB pathway"],"prefix":"10.1007","volume":"34","author":[{"given":"Xi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guokang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,15]]},"reference":[{"key":"368_CR1","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.bcp.2010.08.009","volume":"80","author":"A Bai","year":"2010","unstructured":"Bai A, Ma AG, Yong M, Weiss CR, Ma Y, Guan Q, Bernstein CN, Peng Z (2010) AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis. Biochem Pharmacol 80:1708\u20131717","journal-title":"Biochem Pharmacol"},{"key":"368_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbrc.2017.11.022","volume":"495","author":"YH Chang","year":"2018","unstructured":"Chang YH, Chen YL, Huang WC, Liou CJ (2018) Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1\/AMPK signaling pathway. Biochem Biophys Res Commun 495:197\u2013203","journal-title":"Biochem Biophys Res Commun"},{"key":"368_CR3","doi-asserted-by":"publisher","first-page":"R165","DOI":"10.1186\/ar2850","volume":"11","author":"C Csaki","year":"2009","unstructured":"Csaki C, Mobasheri A, Shakibaei M (2009) Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1betainduced NF-kappaB mediated inflammation and apoptosis. Arthritis Res Ther 11:R165","journal-title":"Arthritis Res Ther"},{"key":"368_CR4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O\u2019Connor JC, Freund GG et al (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46\u201356","journal-title":"Nat Rev Neurosci"},{"key":"368_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1523\/JNEUROSCI.4288-03.2004","volume":"24","author":"S Giri","year":"2004","unstructured":"Giri S, Nath N, Smith B, Viollet B, Singh AK, Singh I (2004) 5-Aminoimidazole-4- carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci 24:479\u2013487","journal-title":"J Neurosci"},{"key":"368_CR6","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.psyneuen.2011.02.008","volume":"36","author":"M Girotti","year":"2011","unstructured":"Girotti M, Donegan JJ, Morilak DA (2011) Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain. Psychoneuroendocrinology 36:1164\u20131174","journal-title":"Psychoneuroendocrinology"},{"key":"368_CR7","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1523\/JNEUROSCI.19-13-05654.1999","volume":"19","author":"S Hayley","year":"1999","unstructured":"Hayley S, Brebner K, Lacosta S, Merali Z, Anisman H (1999) Sensitization to the effects of tumor necrosis factor-alpha: neuroendocrine central monoamine, and behavioral variations. J Neurosci 19:5654\u20135665","journal-title":"J Neurosci"},{"key":"368_CR8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.brainres.2016.08.029","volume":"1649","author":"X Jiang","year":"2016","unstructured":"Jiang X, Chen L, Shen L, Chen Z, Xu L, Zhang J, Yu X (2016) Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice. Brain Res 1649(Pt A) 1649:30\u201337","journal-title":"Brain Res 1649(Pt A)"},{"key":"368_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainresbull.2017.09.010","volume":"135","author":"X Jiang","year":"2017","unstructured":"Jiang X, Liu J, Lin Q, Mao K, Tian F, Jing C, Wang C, Ding L, Pang C (2017) Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway. Brain Res Bull 135:40\u201346","journal-title":"Brain Res Bull"},{"key":"368_CR10","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1001\/jamapsychiatry.2013.1957","volume":"70","author":"LL Judd","year":"2013","unstructured":"Judd LL, Schettler PJ, Coryell W, Akiskal HS, Fiedorowicz JG (2013) Overt irritability\/anger in unipolar major depressive episodes: past and current characteristics and implications for long-term course. JAMA Psychiat 70:1171\u20131180","journal-title":"JAMA Psychiat"},{"key":"368_CR11","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1021\/jf2047652","volume":"60","author":"SI Kang","year":"2012","unstructured":"Kang SI, Shin HS, Kim HM, Yoon SA, Kang SW, Kim JH, Ko HC, Kim SJ (2012) Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. J Agric Food Chem 60:3389\u20133395","journal-title":"J Agric Food Chem"},{"key":"368_CR12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.intimp.2015.07.010","volume":"28","author":"JM Kim","year":"2015","unstructured":"Kim JM, Han HJ, Hur YH, Quan H, Kwak SH, Choi JI, Bae HB (2015) Stearoyl lysophosphatidylcholine prevents lipopolysaccharide-induced extracellular release of high mobility group box-1 through AMP-activated protein kinase activation. Int Immunopharmacol 28:540\u2013545","journal-title":"Int Immunopharmacol"},{"key":"368_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120263","volume":"10","author":"TB Kirsten","year":"2015","unstructured":"Kirsten TB, Galv\u00e3o MC, Reis-Silva TM, Queiroz-Hazarbassanov N, Bernardi MM (2015) Zinc prevents sickness behavior induced by lipopolysaccharides after a stress challenge in rats. PLoS One 10:e0120263","journal-title":"PLoS One"},{"key":"368_CR14","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1073\/pnas.0910658107","volume":"107","author":"JW Koo","year":"2010","unstructured":"Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS (2010) Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A 107:2669\u20132674","journal-title":"Proc Natl Acad Sci U S A"},{"key":"368_CR15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000212746","volume":"61","author":"K Miyashita","year":"2009","unstructured":"Miyashita K (2009) Function of marine carotenoids. Forum Nutr 61:136\u2013146","journal-title":"Forum Nutr"},{"key":"368_CR16","doi-asserted-by":"publisher","first-page":"9075","DOI":"10.1523\/JNEUROSCI.1537-11.2011","volume":"31","author":"FJ Monje","year":"2011","unstructured":"Monje FJ, Cabatic M, Divisch I, Kim EJ, Herkner KR, Binder BR, Pollak DD (2011) Constant darkness induces IL-6-dependent depressive-like behavior through the NF-\u03baB signaling pathway. J Neurosci 31:9075\u20139083","journal-title":"J Neurosci"},{"key":"368_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.neuropharm.2011.09.004","volume":"62","author":"K Montezuma","year":"2012","unstructured":"Montezuma K, Biojone C, Lisboa SF, Cunha FQ, Guimar\u00e3es FS, Joca SRL (2012) Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacology 62:485\u2013491","journal-title":"Neuropharmacology"},{"key":"368_CR18","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1021\/jf400015k","volume":"61","author":"R Pangestuti","year":"2013","unstructured":"Pangestuti R, Vo TS, Ngo DH, Kim SK (2013) Fucoxanthin ameliorates inflammation and oxidative reponses in microglia. J Agric Food Chem 61:3876\u20133883","journal-title":"J Agric Food Chem"},{"key":"368_CR19","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.3390\/md9101806","volume":"9","author":"J Peng","year":"2011","unstructured":"Peng J, Yuan JP, Wu CF, Wang JH (2011) Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs 9:1806\u20131828","journal-title":"Mar Drugs"},{"key":"368_CR20","doi-asserted-by":"crossref","unstructured":"Remus JL, Dantzer R. (2016) Inflammation models of depression in rodents: relevance to psychotropic drug discovery. Int J Neuropsychopharmacol 2016: 19(9). pii: pyw028","DOI":"10.1093\/ijnp\/pyw028"},{"key":"368_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bbi.2014.06.016","volume":"42","author":"E Russo","year":"2014","unstructured":"Russo E, Andreozzi F, Iuliano R, Dattilo V, Procopio T, Fiume G, Mimmi S, Perrotti N, Citraro R, Sesti G, Constanti A, de Sarro G (2014) Early molecular and behavioral response to lipopolysaccharide in the WAG\/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT\/mTOR pathways and neuroinflammatory cytokine release. Brain Behav Immun 42:157\u2013168","journal-title":"Brain Behav Immun"},{"key":"368_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","volume":"11","author":"A Salminen","year":"2012","unstructured":"Salminen A, Kaarniranta K (2012) AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 11:230\u2013241","journal-title":"Ageing Res Rev"},{"key":"368_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075362","volume":"8","author":"DJ Smith","year":"2013","unstructured":"Smith DJ, Nicholl BI, Cullen B, Martin D, Ul-Haq Z, Evans J, Gill JMR, Roberts B, Gallacher J, Mackay D, Hotopf M, Deary I, Craddock N, Pell JP (2013) Prevalence and characteristics of probable major depression and bipolar disorder within UK biobank: cross-sectional study of 172,751 participants. PLoS One 8:e75362","journal-title":"PLoS One"},{"key":"368_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367\u2013370","journal-title":"Psychopharmacology"},{"key":"368_CR25","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s10753-013-9757-1","volume":"37","author":"CP Tan","year":"2014","unstructured":"Tan CP, Hou YH (2014) First evidence for the anti-inflammatory activity of fucoxanthin in high-fat-diet-induced obesity in mice and the antioxidant functions in PC12 cells. Inflammation 37:443\u2013450","journal-title":"Inflammation"},{"key":"368_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.neuroscience.2014.03.025","volume":"268","author":"VS Tomaz","year":"2014","unstructured":"Tomaz VS, Cordeiro RC, Costa AM et al (2014) Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide induced depressive-like behavior in mice. Neuroscience 268:236\u2013246","journal-title":"Neuroscience"},{"key":"368_CR27","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.molmed.2015.07.003","volume":"21","author":"AD Dam Van","year":"2015","unstructured":"Van Dam AD, Kooijman S, Schilperoort M et al (2015) Regulation of brown fat by AMP-activated protein kinase. Trends Mol Med 21:571\u2013579","journal-title":"Trends Mol Med"},{"key":"368_CR28","doi-asserted-by":"publisher","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","volume":"31","author":"ES Wohleb","year":"2011","unstructured":"Wohleb ES, Hanke ML, Corona AW, Powell ND, Stiner LM, Bailey MT, Nelson RJ, Godbout JP, Sheridan JF (2011) Beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci 31:6277\u20136288","journal-title":"J Neurosci"},{"key":"368_CR29","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1021\/acs.jafc.7b00805","volume":"65","author":"S Xiang","year":"2017","unstructured":"Xiang S, Liu F, Lin J, Chen H, Huang C, Chen L, Zhou Y, Ye L, Zhang K, Jin J, Zhen J, Wang C, He S, Wang Q, Cui W, Zhang J (2017) Fucoxanthin inhibits \u03b2-amyloid assembly and attenuates \u03b2-amyloid oligomer-induced cognitive impairments. J Agric Food Chem 65:4092\u20134102","journal-title":"J Agric Food Chem"},{"key":"368_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neulet.2015.05.043","volume":"599","author":"Y Yoshino","year":"2015","unstructured":"Yoshino Y, Ochi S, Yamazaki K, Nakata S, Abe M, Mori Y, Ueno SI (2015) Antidepressant action via the nitric oxide system: a pilot study in an acute depressive model induced by arginin. Neurosci Lett 599:69\u201374","journal-title":"Neurosci Lett"},{"key":"368_CR31","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3109\/02699052.2015.1004746","volume":"29","author":"HY Yu","year":"2015","unstructured":"Yu HY, Cai YB, Liu Z (2015a) Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood-brain barrier in mice. Brain Inj 29:777\u2013784","journal-title":"Brain Inj"},{"key":"368_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11011-014-9554-z","volume":"30","author":"Y Yu","year":"2015","unstructured":"Yu Y, Wu S, Li J, Wang R, Xie X, Yu X, Pan J, Xu Y, Zheng L (2015b) The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metab Brain Dis 30:47\u201355","journal-title":"Metab Brain Dis"},{"key":"368_CR33","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s11011-016-9839-5","volume":"31","author":"X Yu","year":"2016","unstructured":"Yu X, Jiang X, Zhang X, Chen Z, Xu L, Chen L, Wang G, Pan J (2016) The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice. Metab Brain Dis 31:1011\u20131021","journal-title":"Metab Brain Dis"},{"key":"368_CR34","first-page":"723515","volume":"2015","author":"H Zhang","year":"2015","unstructured":"Zhang H, Tang Y, Zhang Y, Zhang S, Qu J, Wang X, Kong R, Han C, Liu Z (2015) Fucoxanthin: a promising medicinal and nutritional ingredient. Evid Based Complement Alternat Med 2015:723515","journal-title":"Evid Based Complement Alternat Med"},{"key":"368_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/srep46763","volume":"7","author":"L Zhang","year":"2017","unstructured":"Zhang L, Wang H, Fan Y, Gao Y, Li X, Hu Z, Ding K, Wang Y, Wang X (2017) Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways. Sci Rep 7:46763","journal-title":"Sci Rep"},{"key":"368_CR36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuint.2013.06.002","volume":"63","author":"J Zlatkovi\u0107","year":"2013","unstructured":"Zlatkovi\u0107 J, Filipovi\u0107 D (2013) Chronic social isolation induces NF-\u03baB activation and upregulation of iNOS protein expression in rat prefrontal cortex. Neurochem Int 63:172\u2013179","journal-title":"Neurochem Int"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0368-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-018-0368-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0368-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T19:06:36Z","timestamp":1576350396000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-018-0368-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,15]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["368"],"URL":"https:\/\/doi.org\/10.1007\/s11011-018-0368-2","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,15]]},"assertion":[{"value":"5 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}