{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:08:11Z","timestamp":1774246091011,"version":"3.50.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s11011-019-00412-5","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:21:00Z","timestamp":1554117660000},"page":"687-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D\u2009+\u2009all-trans retinoic acid + Temozolomide combination in treatment of GBM"],"prefix":"10.1007","volume":"34","author":[{"given":"Ilhan","family":"Elmaci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Ozpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alp","family":"Ozpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7804-4087","authenticated-orcid":false,"given":"Meric A.","family":"Altinoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"412_CR1","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/onc.2015.199","volume":"35","author":"BY Ahn","year":"2016","unstructured":"Ahn BY, Saldanha-Gama RF, Rahn JJ, Hao X, Zhang J, Dang NH, Alshehri M, Robbins SM, Senger DL (2016) Glioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)\/CD271) requires regulated interaction with PDLIM1. Oncogene 35:1411\u20131422","journal-title":"Oncogene"},{"key":"412_CR2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0736-5748(01)00045-4","volume":"19","author":"MA Altinoz","year":"2001","unstructured":"Altinoz MA, Bilir A, Ozar E, Onar FD, Sav A (2001) Medroxyprogesterone acetate alone or synergistic with chemotherapy suppresses colony formation and DNA synthesis in C6 glioma in vitro. Int J Dev Neurosci 19:541\u2013547","journal-title":"Int J Dev Neurosci"},{"key":"412_CR3","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1080\/00207450701540062","volume":"117","author":"MA Altinoz","year":"2007","unstructured":"Altinoz MA, Gedikoglu G, Sav A, Ozcan E, Ozdilli K, Bilir A, Del Maestro RF (2007) Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis\/myelinosis in vitro. Int J Neurosci 117:1465\u20131480","journal-title":"Int J Neurosci"},{"key":"412_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.clineuro.2018.07.012","volume":"173","author":"MA Altinoz","year":"2018","unstructured":"Altinoz MA, Nalbantoglu J, Ozpinar A, Emin Ozcan M, Del Maestro RF, Elmaci I (2018) From epidemiology and neurodevelopment to antineoplasticity. Medroxyprogesterone reduces human glial tumor growth in vitro and C6 glioma in rat brain in vivo. Clin Neurol Neurosurg 173:20\u201330. \n                    https:\/\/doi.org\/10.1016\/j.clineuro.2018.07.012","journal-title":"Clin Neurol Neurosurg"},{"key":"412_CR5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1097-4547(19991015)58:2<293::AID-JNR9>3.0.CO;2-H","volume":"58","author":"M Alvarez-Dolado","year":"1999","unstructured":"Alvarez-Dolado M, Gonz\u00e1lez-Sancho JM, Navarro-Yubero C, Garc\u00eda-Fern\u00e1ndez LF, Mu\u00f1oz A (1999) Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. J Neurosci Res 58:293\u2013300","journal-title":"J Neurosci Res"},{"key":"412_CR6","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s10552-012-0018-7","volume":"23","author":"GM Anic","year":"2012","unstructured":"Anic GM, Thompson RC, Nabors LB, Olson JJ, Browning JE, Madden MH, Murtagh FR, Forsyth PA, Egan KM (2012) An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome. Cancer Causes Control 23:1443\u20131449","journal-title":"Cancer Causes Control"},{"issue":"6","key":"412_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131441","volume":"10","author":"F Atif","year":"2015","unstructured":"Atif F, Patel NR, Yousuf S, Stein DG (2015a) The synergistic effect of combination progesterone and Temozolomide on human glioblastoma cells. PLoS One 10(6):e0131441. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0131441","journal-title":"PLoS One"},{"key":"412_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jsbmb.2014.04.007","volume":"146","author":"F Atif","year":"2015","unstructured":"Atif F, Yousuf S, Stein DG (2015b) Anti-tumor effects of progesterone in human glioblastoma multiforme: role of PI3K\/Akt\/mTOR signaling. J Steroid Biochem Mol Biol 146:62\u201373","journal-title":"J Steroid Biochem Mol Biol"},{"key":"412_CR9","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.3892\/etm.2016.3196","volume":"11","author":"DH Bak","year":"2016","unstructured":"Bak DH, Kang SH, Choi DR, Gil MN, Yu KS, Jeong JH, Lee NS, Lee JH, Jeong YG, Kim DK, Kim DK, Kim JJ, Han SY (2016) Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy. Exp Ther Med 11:2153\u20132162","journal-title":"Exp Ther Med"},{"key":"412_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/(SICI)1097-4547(19961201)46:5<540::AID-JNR3>3.0.CO;2-J","volume":"46","author":"C Baudet","year":"1996","unstructured":"Baudet C, Chevalier G, Chassevent A, Canova C, Filmon R, Larra F, Brachet P, Wion D (1996a) 1,25-Dihydroxyvitamin D3 induces programmed cell death in a rat glioma cell line. J Neurosci Res 46:540\u2013550","journal-title":"J Neurosci Res"},{"key":"412_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0304-3835(95)04054-4","volume":"100","author":"C Baudet","year":"1996","unstructured":"Baudet C, Chevalier G, Naveilhan P, Binderup L, Brachet P, Wion D (1996b) Cytotoxic effects of 1 alpha,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line. Cancer Lett 100:3\u201310","journal-title":"Cancer Lett"},{"key":"412_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/sj.cdd.4400327","volume":"5","author":"C Baudet","year":"1998","unstructured":"Baudet C, Perret E, Delpech B, Kaghad M, Brachet P, Wion D, Caput D (1998) Differentially expressed genes in C6.9 glioma cells during vitamin D-induced cell death program. Cell Death Differ 5:116\u2013125","journal-title":"Cell Death Differ"},{"key":"412_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mcn.2015.10.003","volume":"69","author":"J Berghoff","year":"2015","unstructured":"Berghoff J, Jaisimha AV, Duggan S, MacSharry J, McCarthy JV (2015) Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75(NTR)) mediated glioblastoma cell migration. Mol Cell Neurosci 69:41\u201353","journal-title":"Mol Cell Neurosci"},{"key":"412_CR14","doi-asserted-by":"publisher","unstructured":"Bhatti P, Doody DR, Mckean-Cowdin R, Mueller BA (2015) Neonatal vitamin D and childhood brain tumor risk. Int J Cancer. 136(10):2481\u20135. \n                    https:\/\/doi.org\/10.1002\/ijc.29291","DOI":"10.1002\/ijc.29291"},{"key":"412_CR15","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1212\/01.WNL.0000129984.01327.9D","volume":"63","author":"AV Brenner","year":"2004","unstructured":"Brenner AV, Linet MS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD (2004) Season of birth and risk of brain tumors in adults. Neurology. 63:276\u2013281","journal-title":"Neurology."},{"key":"412_CR16","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1215\/15228517-2008-0047","volume":"10","author":"MC Brown","year":"2008","unstructured":"Brown MC, Staniszewska I, Lazarovici P, Tuszynski GP, Del Valle L, Marcinkiewicz C (2008) Regulatory effect of nerve growth factor in alpha9beta1 integrin-dependent progression of glioblastoma. Neuro-Oncology 10:968\u2013980","journal-title":"Neuro-Oncology"},{"key":"412_CR17","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.ijrobp.2004.08.023","volume":"61","author":"N Butowski","year":"2005","unstructured":"Butowski N, Prados MD, Lamborn KR, Larson DA, Sneed PK, Wara WM, Malec M, Rabbitt J, Page M, Chang SM (2005) A phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma. Int J Radiat Oncol Biol Phys 61:1454\u20131459","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"412_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0047-6374(97)00172-3","volume":"101","author":"C Canova","year":"1998","unstructured":"Canova C, Chevalier G, Remy S, Brachet P, Wion D (1998) Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. Mech Ageing Dev 101:153\u2013166","journal-title":"Mech Ageing Dev"},{"key":"412_CR19","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/ijc.28846","volume":"135","author":"TY Cheng","year":"2014","unstructured":"Cheng TY, Goodman GE, Thornquist MD, Barnett MJ, Beresford SA, LaCroix AZ, Zheng Y, Neuhouser ML (2014) Estimated intake of vitamin D and its interaction with vitamin a on lung cancer risk among smokers. Int J Cancer 135:2135\u20132145. \n                    https:\/\/doi.org\/10.1002\/ijc.28846","journal-title":"Int J Cancer"},{"key":"412_CR20","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1200\/JCO.2008.20.7944","volume":"27","author":"JL Clarke","year":"2009","unstructured":"Clarke JL, Iwamoto FM, Sul J, Panageas K, Lassman AB, DeAngelis LM, Hormigo A, Nolan CP, Gavrilovic I, Karimi S (2009) Abrey LE (2009) randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma. J Clin Oncol 27:3861\u20133867","journal-title":"J Clin Oncol"},{"key":"412_CR21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.clml.2015.11.018","volume":"16","author":"CC Coombs","year":"2016","unstructured":"Coombs CC, DeAngelis LM, Feusner JH, Rowe JM, Tallman MS (2016) Pseudotumor Cerebri in acute Promyelocytic leukemia patients on intergroup protocol 0129: clinical description and recommendations for new diagnostic criteria. Clin Lymphoma Myeloma Leuk 16:146\u2013151. \n                    https:\/\/doi.org\/10.1016\/j.clml.2015.11.018","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"412_CR22","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/07357900701788080","volume":"26","author":"A Das","year":"2008","unstructured":"Das A, Banik NL, Ray SK (2008) Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells. Cancer Investig 26:352\u2013358. \n                    https:\/\/doi.org\/10.1080\/07357900701788080","journal-title":"Cancer Investig"},{"key":"412_CR23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/(SICI)1097-4547(19980415)52:2<210::AID-JNR9>3.0.CO;2-D","volume":"52","author":"N Davoust","year":"1998","unstructured":"Davoust N, Wion D, Chevalier G, Garabedian M, Brachet P, Couez D (1998) Vitamin D receptor stable transfection restores the susceptibility to 1,25-dihydroxyvitamin D3 cytotoxicity in a rat glioma resistant clone. J Neurosci Res 52:210\u2013219","journal-title":"J Neurosci Res"},{"key":"412_CR24","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1158\/1078-0432.CCR-04-1968","volume":"11","author":"B Diesel","year":"2005","unstructured":"Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E (2005) Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res 11:5370\u20135380","journal-title":"Clin Cancer Res"},{"key":"412_CR25","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.3390\/ijerph7051913","volume":"7","author":"JT Efird","year":"2010","unstructured":"Efird JT (2010) Season of birth and risk for adult onset glioma. Int J Environ Res Public Health 7:1913\u20131936","journal-title":"Int J Environ Res Public Health"},{"key":"412_CR26","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10528-016-9754-9","volume":"54","author":"\u0130 Elmaci","year":"2016","unstructured":"Elmaci \u0130, Altinoz MA (2016) A metabolic inhibitory cocktail for grave cancers: metformin, pioglitazone and Lithium combination in treatment of pancreatic Cancer and glioblastoma Multiforme. Biochem Genet 54:573\u2013618","journal-title":"Biochem Genet"},{"key":"412_CR27","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.clnu.2013.04.006","volume":"32","author":"S Field","year":"2013","unstructured":"Field S, Elliott F, Randerson-Moor J, Kukalizch K, Barrett JH, Bishop DT, Newton-Bishop JA (2013) Do vitamin a serum levels moderate outcome or the protective effect of vitamin D on outcome from malignant melanoma? Clin Nutr 32:1012\u20131016. \n                    https:\/\/doi.org\/10.1016\/j.clnu.2013.04.006","journal-title":"Clin Nutr"},{"key":"412_CR28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","volume":"13","author":"E Garcion","year":"2002","unstructured":"Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D (2002) New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 13:100\u2013105","journal-title":"Trends Endocrinol Metab"},{"key":"412_CR29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jsbmb.2012.07.001","volume":"132","author":"E Gocek","year":"2012","unstructured":"Gocek E, Marchwicka A, Baurska H, Chrobak A, Marcinkowska E (2012) Opposite regulation of vitamin D receptor by ATRA in AML cells susceptible and resistant to vitamin D-induced differentiation. J Steroid Biochem Mol Biol 132:220\u2013226. \n                    https:\/\/doi.org\/10.1016\/j.jsbmb.2012.07.001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"412_CR30","doi-asserted-by":"publisher","unstructured":"Grauer O, Pascher C, Hartmann C, Zeman F, Weller M, Proescholdt M, Brawanski A, Pietsch T, Wick W, Bogdahn U, Hau P (2011) Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05). J Neurooncol. 104(3):801\u20139. \n                    https:\/\/doi.org\/10.1007\/s11060-011-0548-y","DOI":"10.1007\/s11060-011-0548-y"},{"key":"412_CR31","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1007\/s00701-009-0438-7","volume":"151","author":"H Hakko","year":"2009","unstructured":"Hakko H, R\u00e4s\u00e4nen P, Niemel\u00e4 A, Koivukangas J, Mainio A (2009) Season of tumor surgery in relation to deaths among brain tumor patients: does sunlight and month of surgery play a role in brain tumor deaths. Acta Neurochir 151:1369\u20131375","journal-title":"Acta Neurochir"},{"key":"412_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1471-4159.2007.04894.x","volume":"103","author":"K Hansen","year":"2007","unstructured":"Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K (2007) Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem 103:259\u2013275","journal-title":"J Neurochem"},{"key":"412_CR33","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1200\/JCO.2003.12.097","volume":"21","author":"KA Jaeckle","year":"2003","unstructured":"Jaeckle KA, Hess KR, Yung WK, Greenberg H, Fine H, Schiff D, Pollack IF, Kuhn J, Fink K, Mehta M et al (2003) North American brain tumor consortium. (2003) phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a north American brain tumor consortium study. J Clin Oncol 21:2305\u20132311","journal-title":"J Clin Oncol"},{"key":"412_CR34","doi-asserted-by":"publisher","first-page":"389","DOI":"10.4103\/0971-5916.159250","volume":"141","author":"PK Jaiswal","year":"2015","unstructured":"Jaiswal PK, Goel A, Mittal RD (2015) Survivin: a molecular biomarker in cancer. Indian J Med Res 141:389\u2013397","journal-title":"Indian J Med Res"},{"key":"412_CR35","doi-asserted-by":"publisher","first-page":"E1323","DOI":"10.3390\/ijms18061323","volume":"18","author":"S Janik","year":"2017","unstructured":"Janik S, Nowak U, \u0141aszkiewicz A, Satyr A, Majkowski M, Marchwicka A, \u015anie\u017cewski \u0141, Berkowska K, Gabry\u015b M, Cebrat M, Marcinkowska E (2017) Diverse regulation of vitamin D receptor gene expression by 1,25-Dihydroxyvitamin D and ATRA in murine and human blood cells at early stages of their differentiation. Int J Mol Sci 18:E1323. \n                    https:\/\/doi.org\/10.3390\/ijms18061323","journal-title":"Int J Mol Sci"},{"key":"412_CR36","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/carcin\/bgx029","volume":"38","author":"S Jawhari","year":"2017","unstructured":"Jawhari S, Bessette B, Hombourger S, Durand K, Lacroix A, Labrousse F, Jauberteau MO, Ratinaud MH, Verdier M (2017) Autophagy and TrkC\/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival. Carcinogenesis. 38:592\u2013603","journal-title":"Carcinogenesis."},{"key":"412_CR37","doi-asserted-by":"publisher","first-page":"b5500","DOI":"10.1136\/bmj.b5500","volume":"340","author":"M Jenab","year":"2010","unstructured":"Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ, Norat T, Pischon T, Jansen EH, Slimani N, Byrnes G, Rinaldi S, Tj\u00f8nneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Morois S, Kaaks R, Linseisen J, Boeing H, Bergmann MM, Trichopoulou A, Misirli G, Trichopoulos D, Berrino F, Vineis P, Panico S, Palli D, Tumino R, Ros MM, van Gils CH, Peeters PH, Brustad M, Lund E, Tormo MJ, Ardanaz E, Rodr\u00edguez L, S\u00e1nchez MJ, Dorronsoro M, Gonzalez CA, Hallmans G, Palmqvist R, Roddam A, Key TJ, Khaw KT, Autier P, Hainaut P, Riboli E (2010) Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study. BMJ 340:b5500. \n                    https:\/\/doi.org\/10.1136\/bmj.b5500","journal-title":"BMJ"},{"key":"412_CR38","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/07420520600921088","volume":"23","author":"HJ Koch","year":"2006","unstructured":"Koch HJ, Klinkhammer-Schalke M, Hofst\u00e4dter F, Bogdahn U, Hau P (2006) Seasonal patterns of birth in patients with glioblastoma. Chronobiol Int 23:1047\u20131052","journal-title":"Chronobiol Int"},{"key":"412_CR39","doi-asserted-by":"publisher","first-page":"838916","DOI":"10.1100\/2012\/838916","volume":"2012","author":"FM Kouri","year":"2012","unstructured":"Kouri FM, Jensen SA, Stegh AH (2012) The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond. ScientificWorldJournal. 2012:838916. \n                    https:\/\/doi.org\/10.1100\/2012\/838916","journal-title":"ScientificWorldJournal."},{"key":"412_CR40","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.4161\/cc.26016","volume":"12","author":"E Lainey","year":"2013","unstructured":"Lainey E, Wolfromm A, Sukkurwala AQ, Micol JB, Fenaux P, Galluzzi L, Kepp O, Kroemer G (2013) EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells. Cell Cycle 12:2978\u20132991","journal-title":"Cell Cycle"},{"key":"412_CR41","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.1074\/jbc.M114.599373","volume":"290","author":"S Lawn","year":"2015","unstructured":"Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher DA, Fournier M, Vrionis FD, Tran N, Chan JA, Kenchappa RS, Forsyth PA (2015) Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem 290:3814\u20133824","journal-title":"J Biol Chem"},{"key":"412_CR42","first-page":"2222","volume":"124","author":"QY Li","year":"2011","unstructured":"Li QY, Yang Y, Zhang Y, Zhang ZJ, Gong AH, Yuan ZC, Lu PS, Zhan LP, Wang P, Feng Y, Xu VL (2011) Nerve growth factor expression in astrocytoma and cerebrospinal fluid: a new biomarker for prognosis of astrocytoma. Chin Med J 124:2222\u20132227","journal-title":"Chin Med J"},{"key":"412_CR43","first-page":"27","volume":"36","author":"L Magrassi","year":"1992","unstructured":"Magrassi L, Bono F, Milanesi G, Butti G (1992) Vitamin D receptor expression in human brain tumors. J Neurosurg Sci 36:27\u201330","journal-title":"J Neurosurg Sci"},{"key":"412_CR44","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/BF01420072","volume":"133","author":"L Magrassi","year":"1995","unstructured":"Magrassi L, Butti G, Pezzotta S, Infuso L, Milanesi G (1995) Effects of vitamin D and retinoic acid on human glioblastoma cell lines. Acta Neurochir 133:184\u2013190","journal-title":"Acta Neurochir"},{"key":"412_CR45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s007010050166","volume":"140","author":"L Magrassi","year":"1998","unstructured":"Magrassi L, Adorni L, Montorfano G, Rapelli S, Butti G, Berra B, Milanesi G (1998) Vitamin D metabolites activate the sphingomyelin pathway and induce death of glioblastoma cells. Acta Neurochir 140:707\u2013713","journal-title":"Acta Neurochir"},{"key":"412_CR46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000094578","volume":"27","author":"A Mainio","year":"2006","unstructured":"Mainio A, Hakko H, Koivukangas J, Niemel\u00e4 A, R\u00e4s\u00e4nen P (2006) Winter birth in association with a risk of brain tumor among a Finnish patient population. Neuroepidemiology. 27:57\u201360","journal-title":"Neuroepidemiology."},{"key":"412_CR47","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11626-016-0072-7","volume":"52","author":"N Maleklou","year":"2016","unstructured":"Maleklou N, Allameh A, Kazemi B (2016) Targeted delivery of vitamin D3-loaded nanoparticles to C6 glioma cell line increased resistance to doxorubicin, epirubicin, and docetaxel in vitro. In Vitro Cell Dev Biol Anim 52:989\u20131000","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"412_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jsbmb.2016.03.013","volume":"159","author":"A Marchwicka","year":"2016","unstructured":"Marchwicka A, Cebrat M, \u0141aszkiewicz A, \u015anie\u017cewski \u0141, Brown G, Marcinkowska E (2016) Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells. J Steroid Biochem Mol Biol 159:121\u2013130. \n                    https:\/\/doi.org\/10.1016\/j.jsbmb.2016.03.013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"412_CR49","first-page":"122","volume":"2","author":"BH Mulpur","year":"2015","unstructured":"Mulpur BH, Nabors LB, Thompson RC, Olson JJ, LaRocca RV, Thompson Z, Egan KM (2015) Complementary therapy and survival in glioblastoma. Neurooncol Pract 2:122\u2013126","journal-title":"Neurooncol Pract"},{"key":"412_CR50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/jnr.490370212","volume":"37","author":"P Naveilhan","year":"1994","unstructured":"Naveilhan P, Berger F, Haddad K, Barbot N, Benabid AL, Brachet P, Wion D (1994) Induction of glioma cell death by 1,25(OH)2 vitamin D3: towards an endocrine therapy of brain tumors? J Neurosci Res 37:271\u2013277","journal-title":"J Neurosci Res"},{"key":"412_CR51","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0169-328X(96)00103-9","volume":"41","author":"P Naveilhan","year":"1996","unstructured":"Naveilhan P, Neveu I, Baudet C, Funakoshi H, Wion D, Brachet P, Metsis M (1996a) 1,25-Dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor. Brain Res Mol Brain Res 41:259\u2013268","journal-title":"Brain Res Mol Brain Res"},{"key":"412_CR52","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1097\/00001756-199609020-00023","volume":"7","author":"P Naveilhan","year":"1996","unstructured":"Naveilhan P, Neveu I, Wion D, Brachet P (1996b) 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport. 7:2171\u20132175","journal-title":"Neuroreport."},{"key":"412_CR53","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/00001756-199412300-00032","volume":"6","author":"I Neveu","year":"1994","unstructured":"Neveu I, Naveilhan P, Baudet C, Brachet P, Metsis M (1994a) 1,25-dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport. 6:124\u2013126","journal-title":"Neuroreport."},{"key":"412_CR54","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0169-328X(94)90119-8","volume":"24","author":"I Neveu","year":"1994","unstructured":"Neveu I, Naveilhan P, Jehan F, Baudet C, Wion D, De Luca HF, Brachet P (1994b) 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res 24:70\u201376","journal-title":"Brain Res Mol Brain Res"},{"key":"412_CR55","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.jocn.2008.06.002","volume":"16","author":"WH Ng","year":"2009","unstructured":"Ng WH, Wan GQ, Peng ZN, Too HP (2009) Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci 16:427\u2013436","journal-title":"J Clin Neurosci"},{"key":"412_CR56","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.1016\/j.bmc.2013.03.068","volume":"21","author":"HM Said","year":"2013","unstructured":"Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, Scozzafava A, Anacker J, Vince GH, Flentje M, Supuran CT (2013) Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma. Bioorg Med Chem 21:3949\u20133957. \n                    https:\/\/doi.org\/10.1016\/j.bmc.2013.03.068","journal-title":"Bioorg Med Chem"},{"key":"412_CR57","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3171\/2016.11.JNS162326","volume":"128","author":"T Saito","year":"2017","unstructured":"Saito T, Sugiyama K, Takeshima Y, Amatya VJ, Yamasaki F, Takayasu T, Nosaka R, Muragaki Y, Kawamata T, Kurisu K (2017) Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide. J Neurosurg 128:679\u2013684. \n                    https:\/\/doi.org\/10.3171\/2016.11.JNS162326","journal-title":"J Neurosurg"},{"key":"412_CR58","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11060-014-1416-3","volume":"118","author":"DG Salom\u00f3n","year":"2014","unstructured":"Salom\u00f3n DG, Fermento ME, Gandini NA, Ferronato MJ, Ar\u00e9valo J, Blasco J, Andr\u00e9s NC, Zenklusen JC, Curino AC, Facchinetti MM (2014) Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme. J Neuro-Oncol 118:49\u201360","journal-title":"J Neuro-Oncol"},{"key":"412_CR59","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0385-8146(03)00091-9","volume":"30","author":"K Satake","year":"2003","unstructured":"Satake K, Takagi E, Ishii A, Kato Y, Imagawa Y, Kimura Y, Tsukuda M (2003) Anti-tumor effect of vitamin a and D on head and neck squamous cell carcinoma. Auris Nasus Larynx 30:403\u2013412","journal-title":"Auris Nasus Larynx"},{"key":"412_CR60","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1007\/s11033-012-1925-0","volume":"40","author":"J Sha","year":"2013","unstructured":"Sha J, Pan J, Ping P, Xuan H, Li D, Bo J, Liu D, Huang Y (2013) Synergistic effect and mechanism of vitamin a and vitamin D on inducing apoptosis of prostate cancer cells. Mol Biol Rep 40:2763\u20132768. \n                    https:\/\/doi.org\/10.1007\/s11033-012-1925-0","journal-title":"Mol Biol Rep"},{"issue":"1","key":"412_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1006323523437","volume":"45","author":"HS Singer","year":"1999","unstructured":"Singer HS, Hansen B, Martinie D, Karp CL (1999) Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and its TrkA receptors. J Neuro-Oncol 45(1):1\u20138","journal-title":"J Neuro-Oncol"},{"key":"412_CR62","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1215\/15228517-2008-025","volume":"10","author":"N Sirachainan","year":"2008","unstructured":"Sirachainan N, Pakakasama S, Visudithbhan A, Chiamchanya S, Tuntiyatorn L, Dhanachai M, Laothamatas J, Hongeng S (2008) Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma. Neuro-Oncology 10:577\u2013582","journal-title":"Neuro-Oncology"},{"key":"412_CR63","doi-asserted-by":"publisher","first-page":"74019","DOI":"10.18632\/oncotarget.18630","volume":"8","author":"S Sun","year":"2017","unstructured":"Sun S, Lei Y, Li Q, Wu Y, Zhang L, Mu PP, Ji GQ, Tang CX, Wang YQ, Gao J, Gao J, Li L, Zhuo L, Li YQ, Gao DS (2017) Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma. Oncotarget. 8:74019\u201374035. \n                    https:\/\/doi.org\/10.18632\/oncotarget.18630","journal-title":"Oncotarget."},{"key":"412_CR64","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1210\/en.2011-1600","volume":"153","author":"S Swami","year":"2012","unstructured":"Swami S, Krishnan AV, Wang JY, Jensen K, Horst R, Albertelli MA, Feldman D (2012) Dietary vitamin D3 and 1,25-dihydroxyvitamin D3 (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology. 153:2576\u20132587","journal-title":"Endocrinology."},{"key":"412_CR65","doi-asserted-by":"publisher","first-page":"634","DOI":"10.2174\/156652412800619978","volume":"12","author":"RE Tamura","year":"2012","unstructured":"Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF (2012) GADD45 proteins: central players in tumorigenesis. Curr Mol Med 12:634\u2013651","journal-title":"Curr Mol Med"},{"key":"412_CR66","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1023\/A:1006437003352","volume":"51","author":"P Trouillas","year":"2001","unstructured":"Trouillas P, Honnorat J, Bret P, Jouvet A, Gerard JP (2001) Redifferentiation therapy in brain tumors: long-lasting complete regression of glioblastomas and an anaplastic astrocytoma under long term 1-alpha-hydroxycholecalciferol. J Neuro-Oncol 51:57\u201366","journal-title":"J Neuro-Oncol"},{"key":"412_CR67","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0304-3835(80)90047-6","volume":"10","author":"SA Vinores","year":"1980","unstructured":"Vinores SA, Koestner A (1980) (1980) the effect of nerve growth factor on undifferentiated glioma cells. Cancer Lett 10:309\u2013318","journal-title":"Cancer Lett"},{"key":"412_CR68","first-page":"2040","volume":"60","author":"Q Wang","year":"2000","unstructured":"Wang Q, Yang W, Uytingco MS, Christakos S, Wieder R (2000) 1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death. Cancer Res 60:2040\u20132048","journal-title":"Cancer Res"},{"key":"412_CR69","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/PL00007416","volume":"99","author":"B Wiesenhofer","year":"2000","unstructured":"Wiesenhofer B, Stockhammer G, Kostron H, Maier H, Hinterhuber H, Humpel C (2000a) Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-alpha 1) are strongly expressed in human gliomas. Acta Neuropathol 99:131\u2013137","journal-title":"Acta Neuropathol"},{"key":"412_CR70","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/oli.1.2000.10.311","volume":"10","author":"B Wiesenhofer","year":"2000","unstructured":"Wiesenhofer B, Weis C, Humpel C (2000b) Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments. Antisense Nucleic Acid Drug Dev 10:311\u2013321","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"412_CR71","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1007\/s13277-013-1544-y","volume":"35","author":"Y Xu","year":"2014","unstructured":"Xu Y, He B, Pan Y, Deng Q, Sun H, Li R, Gao T, Song G, Wang S (2014) Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Tumour Biol 35:4153\u20134169","journal-title":"Tumour Biol"},{"key":"412_CR72","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/jb\/mvs074","volume":"152","author":"T Yagishita","year":"2012","unstructured":"Yagishita T, Kushida A, Tamura H (2012) Vitamin D(3) enhances ATRA-mediated neurosteroid biosynthesis in human glioma GI-1 cells. J Biochem 152:285\u2013292","journal-title":"J Biochem"},{"key":"412_CR73","doi-asserted-by":"publisher","first-page":"8469","DOI":"10.1128\/MCB.19.12.8469","volume":"19","author":"K Yamamoto","year":"1999","unstructured":"Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1\/Jun N-terminal protein kinase pathway normally activated at G(2)\/M. Mol Cell Biol 19:8469\u20138478","journal-title":"Mol Cell Biol"},{"key":"412_CR74","doi-asserted-by":"publisher","first-page":"464","DOI":"10.4103\/0976-3147.120210","volume":"4","author":"SA Zaki","year":"2013","unstructured":"Zaki SA, Lad V, Abdagire N (2013) Vitamin D deficiency rickets presenting as pseudotumor cerebri. J Neurosci Rural Pract 4:464\u2013466. \n                    https:\/\/doi.org\/10.4103\/0976-3147.120210","journal-title":"J Neurosci Rural Pract"},{"key":"412_CR75","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000336483","volume":"82","author":"D Zapletalova","year":"2012","unstructured":"Zapletalova D, Andr\u00e9 N, Deak L, Kyr M, Bajciova V, Mudry P, Dubska L, Demlova R, Pavelka Z, Zitterbart K, Skotakova J, Husek K, Martincekova A, Mazanek P, Kepak T, Doubek M, Kutnikova L, Valik D, Sterba J (2012) Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: a multicenter experience. Oncology. 82:249\u2013260","journal-title":"Oncology."},{"key":"412_CR76","first-page":"888","volume":"86","author":"D Zehnder","year":"2001","unstructured":"Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M (2001) Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86:888\u2013894","journal-title":"J Clin Endocrinol Metab"},{"key":"412_CR77","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15099","volume":"5","author":"X Zhou","year":"2016","unstructured":"Zhou X, Hao Q, Liao P, Luo S, Zhang M, Hu G, Liu H, Zhang Y, Cao B, Baddoo M, Flemington EK, Zeng SX, Lu H (2016) Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. Elife. 5:e15099. \n                    https:\/\/doi.org\/10.7554\/eLife.15099","journal-title":"Elife."},{"key":"412_CR78","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1080\/01635581.2015.1073757","volume":"67","author":"V Zigmont","year":"2015","unstructured":"Zigmont V, Garrett A, Peng J, Seweryn M, Rempala GA, Harris R, Holloman C, Gundersen TE, Ahlbom A, Feychting M, Johannesen TB, Grimsrud TK, Schwartzbaum J (2015) Association between Prediagnostic serum 25-Hydroxyvitamin D concentration and glioma. Nutr Cancer 67:1120\u20131130","journal-title":"Nutr Cancer"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-019-00412-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-019-00412-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-019-00412-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T23:15:58Z","timestamp":1585610158000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-019-00412-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["412"],"URL":"https:\/\/doi.org\/10.1007\/s11011-019-00412-5","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]},"assertion":[{"value":"12 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}