{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:49:05Z","timestamp":1790984945297,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"UPCST","award":["CST,UP (CST\/SERPD\/D-2794)"],"award-info":[{"award-number":["CST,UP (CST\/SERPD\/D-2794)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s11011-019-00526-w","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T13:02:36Z","timestamp":1576242156000},"page":"517-525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Neuroprotective effects of Bacopa monnieri in Parkinson\u2019s disease model"],"prefix":"10.1007","volume":"35","author":[{"given":"Babita","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rumman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"526_CR1","doi-asserted-by":"publisher","first-page":"117739281986641","DOI":"10.1177\/1177392819866412","volume":"13","author":"AS Abdul Manap","year":"2019","unstructured":"Abdul Manap AS, Vijayabalan S, Madhavan P, Chia YY, Arya A, Wong EH, Rizwan F, Bindal U, Koshy S (2019) Bacopa monnieri, a Neuroprotective Lead in Alzheimer disease: a review on its properties, mechanisms of action, and preclinical and clinical studies. Drug Target Insights 13:117739281986641. https:\/\/doi.org\/10.1177\/1177392819866412","journal-title":"Drug Target Insights"},{"issue":"1","key":"526_CR2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12906-017-1731-2","volume":"17","author":"S Ahn","year":"2017","unstructured":"Ahn S, Song TJ, Park SU, Jeon S, Kim J, Oh JY, Jang J, Hong S, Song MA, Shin HS, Jung YR, Park HJ (2017) Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson\u2019s disease. BMC Complement Altern Med 17(1):220\u2013214. https:\/\/doi.org\/10.1186\/s12906-017-1731-2","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"526_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001376","volume":"3","author":"EJ Benner","year":"2008","unstructured":"Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P, Przedborski S, Mosley RL, Gendelman HE (2008) Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One 3(1):e1376. https:\/\/doi.org\/10.1371\/journal.pone.0001376","journal-title":"PLoS One"},{"issue":"1\u20132","key":"526_CR4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jep.2005.10.009","volume":"104","author":"S Channa","year":"2006","unstructured":"Channa S, Dar A, Anjum S, Yaqoob M, Atta Ur R (2006) Anti-inflammatory activity of Bacopa monniera in rodents. J Ethnopharmacol 104(1\u20132):286\u2013289. https:\/\/doi.org\/10.1016\/j.jep.2005.10.009","journal-title":"J Ethnopharmacol"},{"key":"526_CR5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.brainres.2013.06.027","volume":"1527","author":"IH Choe","year":"2013","unstructured":"Choe IH, Yeo S, Chung KC, Kim SH, Lim S (2013) Decreased and increased cerebral regional homogeneity in early Parkinson\u2019s disease. Brain Res 1527:230\u2013237. https:\/\/doi.org\/10.1016\/j.brainres.2013.06.027","journal-title":"Brain Res"},{"key":"526_CR6","doi-asserted-by":"publisher","first-page":"898192","DOI":"10.1155\/2015\/898192","volume":"2015","author":"M Dufek","year":"2015","unstructured":"Dufek M, Rektorova I, Thon V, Lokaj J, Rektor I (2015) Interleukin-6 may contribute to mortality in Parkinson\u2019s disease patients: A 4-year prospective study. Parkinsons Dis 2015:898192. https:\/\/doi.org\/10.1155\/2015\/898192","journal-title":"Parkinsons Dis"},{"issue":"4","key":"526_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37(4):277\u2013285. https:\/\/doi.org\/10.1016\/j.clinbiochem.2003.11.015","journal-title":"Clin Biochem"},{"key":"526_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fnana.2015.00032","volume":"9","author":"MT Herrero","year":"2015","unstructured":"Herrero MT, Estrada C, Maatouk L, Vyas S (2015) Inflammation in Parkinson\u2019s disease: role of glucocorticoids. Front Neuroanat 9:32. https:\/\/doi.org\/10.3389\/fnana.2015.00032","journal-title":"Front Neuroanat"},{"issue":"2","key":"526_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00401-004-0919-y","volume":"109","author":"K Imamura","year":"2005","unstructured":"Imamura K, Hishikawa N, Ono K, Suzuki H, Sawada M, Nagatsu T, Yoshida M, Hashizume Y (2005) Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains. Acta Neuropathol 109(2):141\u2013150. https:\/\/doi.org\/10.1007\/s00401-004-0919-y","journal-title":"Acta Neuropathol"},{"issue":"24","key":"526_CR10","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.2174\/0929867323666160812151356","volume":"23","author":"FJ Jimenez-Jimenez","year":"2016","unstructured":"Jimenez-Jimenez FJ, Alonso-Navarro H, Herrero MT, Garcia-Martin E, Aqundez J, A. (2016) An update on role of nitric oxide in the neurodegenerative processes of Parkinson\u2019s disease. Curr Med Chem 23(24):2666\u20132679. https:\/\/doi.org\/10.2174\/0929867323666160812151356","journal-title":"Curr Med Chem"},{"issue":"12","key":"526_CR11","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S1995-7645(12)60180-1","volume":"5","author":"V Kamesh","year":"2012","unstructured":"Kamesh V, Sumathi T (2012) Antihypercholesterolemic effect of Bacopa monniera linn. on high cholesterol diet induced hypercholesterolemia in rats. Asian Pac J Trop Med 5(12):949\u2013955. https:\/\/doi.org\/10.1016\/S1995-7645(12)60180-1","journal-title":"Asian Pac J Trop Med"},{"issue":"2","key":"526_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5607\/en.2013.22.2.77","volume":"22","author":"HJ Kim","year":"2013","unstructured":"Kim HJ (2013) Alpha-synuclein expression in patients with Parkinson\u2019s disease: a clinical perspective. Exp Neurobiol 22(2):77\u201383. https:\/\/doi.org\/10.5607\/en.2013.22.2.77","journal-title":"Exp Neurobiol"},{"key":"526_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1742-2094-7-83","volume":"7","author":"F L'Episcopo","year":"2010","unstructured":"L'Episcopo F, Tirolo C, Caniglia S, Testa N, Serra PA, Impagnatiello F, Morale MC, Marchetti B (2010) Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neuroinflammation 7:83. https:\/\/doi.org\/10.1186\/1742-2094-7-83","journal-title":"J Neuroinflammation"},{"issue":"8","key":"526_CR14","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","volume":"38","author":"PL McGeer","year":"1988","unstructured":"McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains. Neurology 38(8):1285\u20131291","journal-title":"Neurology"},{"issue":"8","key":"526_CR15","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2174\/1381612053381620","volume":"11","author":"T Nagatsu","year":"2005","unstructured":"Nagatsu T, Sawada M (2005) Inflammatory process in Parkinson\u2019s disease: role for cytokines. Curr Pharm Des 11(8):999\u20131016","journal-title":"Curr Pharm Des"},{"key":"526_CR16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jep.2016.07.073","volume":"197","author":"MD Nemetchek","year":"2017","unstructured":"Nemetchek MD, Stierle AA, Stierle DB, Lurie DI (2017) The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. J Ethnopharmacol 197:92\u2013100. https:\/\/doi.org\/10.1016\/j.jep.2016.07.073","journal-title":"J Ethnopharmacol"},{"key":"526_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jchemneu.2015.12.002","volume":"71","author":"SN Rai","year":"2016","unstructured":"Rai SN, Yadav SK, Singh D, Singh SP (2016) Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model. J Chem Neuroanat 71:41\u201349. https:\/\/doi.org\/10.1016\/j.jchemneu.2015.12.002","journal-title":"J Chem Neuroanat"},{"key":"526_CR18","doi-asserted-by":"publisher","first-page":"628192","DOI":"10.1155\/2015\/628192","volume":"2015","author":"NP Rocha","year":"2015","unstructured":"Rocha NP, de Miranda AS, Teixeira AL (2015) Insights into neuroinflammation in Parkinson\u2019s disease: from biomarkers to anti-inflammatory based therapies. Biomed Res Int 2015:628192. https:\/\/doi.org\/10.1155\/2015\/628192","journal-title":"Biomed Res Int"},{"issue":"1","key":"526_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","volume":"137","author":"K Saijo","year":"2009","unstructured":"Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH, Glass CK (2009) A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137(1):47\u201359. https:\/\/doi.org\/10.1016\/j.cell.2009.01.038","journal-title":"Cell"},{"key":"526_CR20","doi-asserted-by":"crossref","unstructured":"Sawada M, Imamura K, Nagatsu T (2006) Role of cytokines in inflammatory process in Parkinson\u2019s disease. J Neural Transm Suppl (70):373\u2013381","DOI":"10.1007\/978-3-211-45295-0_57"},{"issue":"2","key":"526_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12640-011-9303-6","volume":"22","author":"GK Shinomol","year":"2012","unstructured":"Shinomol GK, Bharath MM, Muralidhara (2012) Neuromodulatory propensity of Bacopa monnieri leaf extract against 3-nitropropionic acid-induced oxidative stress: in vitro and in vivo evidences. Neurotox Res 22(2):102\u2013114. https:\/\/doi.org\/10.1007\/s12640-011-9303-6","journal-title":"Neurotox Res"},{"key":"526_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.brainresbull.2017.10.007","volume":"135","author":"B Singh","year":"2017","unstructured":"Singh B, Pandey S, Yadav SK, Verma R, Singh SP, Mahdi AA (2017) Role of ethanolic extract of Bacopa monnieri against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice model via inhibition of apoptotic pathways of dopaminergic neurons. Brain Res Bull 135:120\u2013128. https:\/\/doi.org\/10.1016\/j.brainresbull.2017.10.007","journal-title":"Brain Res Bull"},{"issue":"2","key":"526_CR23","doi-asserted-by":"publisher","first-page":"a009399","DOI":"10.1101\/cfhperspect.a009399","volume":"2","author":"L Stefanis","year":"2012","unstructured":"Stefanis L (2012) Alpha-synuclein in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2(2):a009399. https:\/\/doi.org\/10.1101\/cfhperspect.a009399","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"526_CR24","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1037\/a0019077","volume":"117","author":"A Stocco","year":"2010","unstructured":"Stocco A, Lebiere C, Anderson JR (2010) Conditional routing of information to the cortex: a model of the basal ganglia\u2019s role in cognitive coordination. Psychol Rev 117(2):541\u2013574. https:\/\/doi.org\/10.1037\/a0019077","journal-title":"Psychol Rev"},{"issue":"1","key":"526_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2007.07.004","volume":"208","author":"MG Tansey","year":"2007","unstructured":"Tansey MG, McCoy MK, Frank-Cannon TC (2007) Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 208(1):1\u201325. https:\/\/doi.org\/10.1016\/j.expneurol.2007.07.004","journal-title":"Exp Neurol"},{"issue":"2","key":"526_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/mds.10332","volume":"18","author":"P Teismann","year":"2003","unstructured":"Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S (2003) Pathogenic role of glial cells in Parkinson's disease. Mov Disord 18(2):121\u2013129. https:\/\/doi.org\/10.1002\/mds.10332","journal-title":"Mov Disord"},{"issue":"10","key":"526_CR27","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1096\/fj.00-0300com","volume":"15","author":"AS Vrablic","year":"2001","unstructured":"Vrablic AS, Albright CD, Craciunescu CN, Salganik RI, Zeisel SH (2001) Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes. FASEB J 15(10):1739\u20131744","journal-title":"FASEB J"},{"key":"526_CR28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.brainres.2016.11.020","volume":"1655","author":"Zhen-Nian Zhang","year":"2017","unstructured":"Zhang ZN, Zhang JS, Xiang J, Yu ZH, Zhang W, Cai M, Li XT, Wu T, Le WW, Cai DF (2017) Subcutaneous rotenone rat model of Parkinson\u2019s disease: dose exploration study. Brain Res 1655:104\u2013113. https:\/\/doi.org\/10.1016\/j.brainres.2016.11.020","journal-title":"Brain Research"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-019-00526-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-019-00526-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-019-00526-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T01:21:35Z","timestamp":1607736095000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-019-00526-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["526"],"URL":"https:\/\/doi.org\/10.1007\/s11011-019-00526-w","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"1 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}