{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:43:38Z","timestamp":1768355018210,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602846"],"award-info":[{"award-number":["81602846"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn201812159"],"award-info":[{"award-number":["tsqn201812159"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s11011-020-00616-0","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T14:06:27Z","timestamp":1600351587000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Circulating sortilin levels are associated with inflammation in patients with moyamoya disease"],"prefix":"10.1007","volume":"36","author":[{"given":"Wenxiu","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"616_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","volume":"7","author":"NJ Abbott","year":"2006","unstructured":"Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41\u201353. https:\/\/doi.org\/10.1038\/nrn1824","journal-title":"Nat Rev Neurosci"},{"key":"616_CR2","doi-asserted-by":"publisher","first-page":"E1968","DOI":"10.1073\/pnas.1616070114","volume":"114","author":"MJ Aragon","year":"2017","unstructured":"Aragon MJ et al (2017) Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood-brain barrier impairment. Proc Natl Acad Sci U S A 114:E1968\u2013E1976. https:\/\/doi.org\/10.1073\/pnas.1616070114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"616_CR3","doi-asserted-by":"publisher","first-page":"48ps46","DOI":"10.1126\/scitranslmed.3001557","volume":"2","author":"AC Calkin","year":"2010","unstructured":"Calkin AC, Tontonoz P (2010) Genome-wide association studies identify new targets in cardiovascular disease. Sci Transl Med 2:48ps46. https:\/\/doi.org\/10.1126\/scitranslmed.3001557","journal-title":"Sci Transl Med"},{"key":"616_CR4","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1523\/jneurosci.2425-12.2013","volume":"33","author":"AS Carlo","year":"2013","unstructured":"Carlo AS et al (2013) The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain. J Neurosci 33:358\u2013370. https:\/\/doi.org\/10.1523\/jneurosci.2425-12.2013","journal-title":"J Neurosci"},{"key":"616_CR5","doi-asserted-by":"publisher","first-page":"e102382","DOI":"10.1371\/journal.pone.0102382","volume":"9","author":"D Dai","year":"2014","unstructured":"Dai D et al (2014) Serum miRNA signature in Moyamoya disease. PLoS One 9:e102382. https:\/\/doi.org\/10.1371\/journal.pone.0102382","journal-title":"PLoS One"},{"key":"616_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.brainres.2017.11.013","volume":"1679","author":"M Fujimura","year":"2018","unstructured":"Fujimura M et al (2018) Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis. Brain Res 1679:39\u201344. https:\/\/doi.org\/10.1016\/j.brainres.2017.11.013","journal-title":"Brain Res"},{"issue":"Suppl 2","key":"616_CR7","doi-asserted-by":"publisher","first-page":"S238","DOI":"10.1016\/S0303-8467(97)00082-6","volume":"99","author":"M Fukui","year":"1997","unstructured":"Fukui M (1997) Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis (\u2018moyamoya\u2019 disease). Research committee on spontaneous occlusion of the circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan. Clin Neurol Neurosurg 99(Suppl 2):S238\u2013S240","journal-title":"Clin Neurol Neurosurg"},{"key":"616_CR8","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.neuron.2010.09.034","volume":"68","author":"F Hu","year":"2010","unstructured":"Hu F et al (2010) Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68:654\u2013667. https:\/\/doi.org\/10.1016\/j.neuron.2010.09.034","journal-title":"Neuron"},{"key":"616_CR9","doi-asserted-by":"publisher","first-page":"31379","DOI":"10.1074\/jbc.271.49.31379","volume":"271","author":"L Jacobsen","year":"1996","unstructured":"Jacobsen L et al (1996) Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem 271:31379\u201331383. https:\/\/doi.org\/10.1074\/jbc.271.49.31379","journal-title":"J Biol Chem"},{"key":"616_CR10","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1136\/jnnp.2009.191817","volume":"81","author":"HS Kang","year":"2010","unstructured":"Kang HS et al (2010) Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease. J Neurol Neurosurg Psychiatry 81:673\u2013678. https:\/\/doi.org\/10.1136\/jnnp.2009.191817","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"616_CR11","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cmet.2010.08.006","volume":"12","author":"M Kjolby","year":"2010","unstructured":"Kjolby M et al (2010) Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab 12:213\u2013223. https:\/\/doi.org\/10.1016\/j.cmet.2010.08.006","journal-title":"Cell Metab"},{"key":"616_CR12","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/jnnp-2011-301387","volume":"83","author":"R Kleinloog","year":"2012","unstructured":"Kleinloog R, Regli L, Rinkel GJ, Klijn CJ (2012) Regional differences in incidence and patient characteristics of moyamoya disease: a systematic review. J Neurol Neurosurg Psychiatry 83:531\u2013536. https:\/\/doi.org\/10.1136\/jnnp-2011-301387","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"616_CR13","doi-asserted-by":"publisher","unstructured":"Larsen JV, Petersen CM (2017) SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol 37. https:\/\/doi.org\/10.1128\/mcb.00641-16","DOI":"10.1128\/mcb.00641-16"},{"key":"616_CR14","doi-asserted-by":"publisher","first-page":"9792412","DOI":"10.1155\/2019\/9792412","volume":"2019","author":"W Ma","year":"2019","unstructured":"Ma W et al (2019) Serum uric acid and triglycerides in Chinese patients with newly diagnosed moyamoya disease: A cross-sectional study. Biomed Res Int 2019:9792412. https:\/\/doi.org\/10.1155\/2019\/9792412","journal-title":"Biomed Res Int"},{"key":"616_CR15","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2019-0059","author":"T Mikami","year":"2019","unstructured":"Mikami T, Suzuki H, Komatsu K, Mikuni N (2019) Influence of inflammatory disease on the pathophysiology of moyamoya disease and quasi-moyamoya disease. Neurol Med Chir (Tokyo). https:\/\/doi.org\/10.2176\/nmc.ra.2019-0059","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"616_CR16","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1172\/jci76002","volume":"124","author":"MB Mortensen","year":"2014","unstructured":"Mortensen MB et al (2014) Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. J Clin Invest 124:5317\u20135322. https:\/\/doi.org\/10.1172\/jci76002","journal-title":"J Clin Invest"},{"key":"616_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neulet.2010.01.023","volume":"471","author":"EJ Mufson","year":"2010","unstructured":"Mufson EJ, Wuu J, Counts SE, Nykjaer A (2010) Preservation of cortical sortilin protein levels in MCI and Alzheimer\u2019s disease. Neurosci Lett 471:129\u2013133. https:\/\/doi.org\/10.1016\/j.neulet.2010.01.023","journal-title":"Neurosci Lett"},{"key":"616_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00701-019-03811-w","volume":"161","author":"A Narducci","year":"2019","unstructured":"Narducci A, Yasuyuki K, Onken J, Blecharz K, Vajkoczy P (2019) In vivo demonstration of blood-brain barrier impairment in Moyamoya disease. Acta Neurochir (Wien) 161:371\u2013378. https:\/\/doi.org\/10.1007\/s00701-019-03811-w","journal-title":"Acta Neurochir (Wien)"},{"key":"616_CR19","doi-asserted-by":"publisher","first-page":"8832","DOI":"10.1074\/jbc.274.13.8832","volume":"274","author":"MS Nielsen","year":"1999","unstructured":"Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM (1999) Sortilin\/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 274:8832\u20138836. https:\/\/doi.org\/10.1074\/jbc.274.13.8832","journal-title":"J Biol Chem"},{"key":"616_CR20","doi-asserted-by":"publisher","first-page":"25920","DOI":"10.1074\/jbc.M802721200","volume":"283","author":"SK Nilsson","year":"2008","unstructured":"Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G (2008) Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem 283:25920\u201325927. https:\/\/doi.org\/10.1074\/jbc.M802721200","journal-title":"J Biol Chem"},{"key":"616_CR21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.tins.2012.01.003","volume":"35","author":"A Nykjaer","year":"2012","unstructured":"Nykjaer A, Willnow TE (2012) Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci 35:261\u2013270. https:\/\/doi.org\/10.1016\/j.tins.2012.01.003","journal-title":"Trends Neurosci"},{"key":"616_CR22","doi-asserted-by":"publisher","first-page":"13191","DOI":"10.1038\/srep13191","volume":"5","author":"K Ohkubo","year":"2015","unstructured":"Ohkubo K et al (2015) Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Sci Rep 5:13191. https:\/\/doi.org\/10.1038\/srep13191","journal-title":"Sci Rep"},{"key":"616_CR23","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1161\/circresaha.116.305811","volume":"116","author":"KM Patel","year":"2015","unstructured":"Patel KM et al (2015) Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res 116:789\u2013796. https:\/\/doi.org\/10.1161\/circresaha.116.305811","journal-title":"Circ Res"},{"key":"616_CR24","doi-asserted-by":"publisher","first-page":"E7049","DOI":"10.1073\/pnas.1604992113","volume":"113","author":"AB Patel","year":"2016","unstructured":"Patel AB, Tsilioni I, Leeman SE (2016) Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A 113:E7049\u2013E7058. https:\/\/doi.org\/10.1073\/pnas.1604992113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"616_CR25","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1074\/jbc.272.6.3599","volume":"272","author":"CM Petersen","year":"1997","unstructured":"Petersen CM et al (1997) Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 272:3599\u20133605. https:\/\/doi.org\/10.1074\/jbc.272.6.3599","journal-title":"J Biol Chem"},{"key":"616_CR26","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng1943","volume":"39","author":"E Rogaeva","year":"2007","unstructured":"Rogaeva E et al (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39:168\u2013177. https:\/\/doi.org\/10.1038\/ng1943","journal-title":"Nat Genet"},{"key":"616_CR27","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/jcbfm.2011.197","volume":"32","author":"GA Rosenberg","year":"2012","unstructured":"Rosenberg GA (2012) Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab 32:1139\u20131151. https:\/\/doi.org\/10.1038\/jcbfm.2011.197","journal-title":"J Cereb Blood Flow Metab"},{"key":"616_CR28","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","volume":"360","author":"RM Scott","year":"2009","unstructured":"Scott RM, Smith ER (2009) Moyamoya disease and moyamoya syndrome. N Engl J Med 360:1226\u20131237. https:\/\/doi.org\/10.1056\/NEJMra0804622","journal-title":"N Engl J Med"},{"key":"616_CR29","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/00006123-200203000-00022","volume":"50","author":"SG Soriano","year":"2002","unstructured":"Soriano SG, Cowan DB, Proctor MR, Scott RM (2002) Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery 50:544\u2013549. https:\/\/doi.org\/10.1097\/00006123-200203000-00022","journal-title":"Neurosurgery"},{"key":"616_CR30","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1083\/jcb.201712120","volume":"218","author":"M Sugihara","year":"2019","unstructured":"Sugihara M et al (2019) The AAA + ATPase\/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets. J Cell Biol 218:949\u2013960. https:\/\/doi.org\/10.1083\/jcb.201712120","journal-title":"J Cell Biol"},{"key":"616_CR31","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1093\/hmg\/ddy376","volume":"28","author":"SE Sullivan","year":"2019","unstructured":"Sullivan SE et al (2019) Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Abeta and TAU proteostasis. Hum Mol Genet 28:718\u2013735. https:\/\/doi.org\/10.1093\/hmg\/ddy376","journal-title":"Hum Mol Genet"},{"key":"616_CR32","doi-asserted-by":"publisher","first-page":"350","DOI":"10.5853\/jos.2018.00962","volume":"20","author":"HY Sung","year":"2018","unstructured":"Sung HY et al (2018) Aberrant promoter hypomethylation of sortilin 1: A moyamoya disease biomarker. J Stroke 20:350\u2013361. https:\/\/doi.org\/10.5853\/jos.2018.00962","journal-title":"J Stroke"},{"key":"616_CR33","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","volume":"20","author":"J Suzuki","year":"1969","unstructured":"Suzuki J, Takaku A (1969) Cerebrovascular \u201cmoyamoya\u201d disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol 20:288\u2013299. https:\/\/doi.org\/10.1001\/archneur.1969.00480090076012","journal-title":"Arch Neurol"},{"key":"616_CR34","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.scitotenv.2019.06.387","volume":"689","author":"J Wang","year":"2019","unstructured":"Wang J et al (2019) Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. Sci Total Environ 689:662\u2013678. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.06.387","journal-title":"Sci Total Environ"},{"key":"616_CR35","doi-asserted-by":"publisher","first-page":"26566","DOI":"10.1038\/srep26566","volume":"6","author":"T Yabe-Wada","year":"2016","unstructured":"Yabe-Wada T et al (2016) TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin. Sci Rep 6:26566. https:\/\/doi.org\/10.1038\/srep26566","journal-title":"Sci Rep"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-020-00616-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-020-00616-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-020-00616-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:58:36Z","timestamp":1631840316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-020-00616-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["616"],"URL":"https:\/\/doi.org\/10.1007\/s11011-020-00616-0","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]},"assertion":[{"value":"12 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}