{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:20:24Z","timestamp":1783099224601,"version":"3.54.6"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Major Project of Science and Technology Department in Tibet Autonomous Region of China","award":["2015XZ01G21"],"award-info":[{"award-number":["2015XZ01G21"]}]},{"name":"Project of Testing Technique in Tibetan Medicine from Ministry of Education in China"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11011-020-00653-9","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T11:04:21Z","timestamp":1610017461000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The pathophysiological mechanism of ischemic stroke after hypobaric hypoxia simulation at high altitude"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-1226","authenticated-orcid":false,"given":"Minxia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"653_CR1","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s00109-017-1584-7","volume":"95","author":"P Azad","year":"2017","unstructured":"Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG (2017) High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl) 95:1269\u20131282","journal-title":"J Mol Med (Berl)"},{"key":"653_CR2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/jnc.12101","volume":"124","author":"AN Baucum","year":"2013","unstructured":"Baucum AN, Brown AM, Colbran RJ (2013) Differential association of postsynaptic signaling protein complexes in striatum and hippocampus. J Neurochem 124:490\u2013501","journal-title":"J Neurochem"},{"key":"653_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clineuro.2017.03.025","volume":"157","author":"R Chen","year":"2017","unstructured":"Chen R, Xiao A, Ma L, Li H, Lin S, You C (2017) Elevated hemoglobin is associated with cerebral infarction in Tibetan patients with primary hemorrhagic neurovascular diseases. Clin Neurol Neurosurg 157:46\u201350","journal-title":"Clin Neurol Neurosurg"},{"key":"653_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000330558","volume":"66","author":"J Fang","year":"2011","unstructured":"Fang J, Zhuo-Ga C, Zhao Y, Kong F, Si Y, Liu M, Zhou D (2011) Characteristics of stroke in Tibet autonomous region in China: a hospital-based study of acute stroke. Eur Neurol 66:151\u2013158","journal-title":"Eur Neurol"},{"key":"653_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1089\/152702902753639513","volume":"3","author":"SK Jha","year":"2002","unstructured":"Jha SK, Anand AC, Sharma V, Kumar N, Adya CM (2002) Stroke at high altitude: Indian experience. High Alt Med Biol 3:21\u201327","journal-title":"High Alt Med Biol"},{"key":"653_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","volume":"115","author":"TW Lai","year":"2014","unstructured":"Lai TW, Zhang S, Wang YT (2014) Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol 115:157\u2013188","journal-title":"Prog Neurobiol"},{"key":"653_CR7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84\u201391","journal-title":"Stroke"},{"key":"653_CR8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejmech.2018.11.014","volume":"162","author":"Y Luo","year":"2019","unstructured":"Luo Y, Tang H, Li H, Zhao R, Huang Q, Liu J (2019) Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia. Eur J Med Chem 162:132\u2013146","journal-title":"Eur J Med Chem"},{"key":"653_CR9","doi-asserted-by":"crossref","first-page":"e21183","DOI":"10.1136\/bmjopen-2017-021183","volume":"8","author":"B Piccardi","year":"2018","unstructured":"Piccardi B, Arba F, Nesi M, Palumbo V, Nencini P, Giusti B, Sereni A, Gadda D, Moretti M, Fainardi E, Mangiafico S, Pracucci G, Nannoni S, Galmozzi F, Fanelli A, Pezzati P, Vanni S, Grifoni S, Sarti C, Lamassa M, Poggesi A, Pescini F, Pantoni L, Gori AM, Inzitari D (2018) Reperfusion injury after ischemic stroke study (RISKS): single-Centre (Florence, Italy), prospective observational protocol study. BMJ Open 8:e21183","journal-title":"BMJ Open"},{"key":"653_CR10","first-page":"26","volume":"3","author":"H Wang","year":"2016","unstructured":"Wang H, Peng RY (2016) Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity. Mil Med Res 3:26","journal-title":"Mil Med Res"},{"key":"653_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","volume":"135","author":"W Wang","year":"2017","unstructured":"Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, Wang L, Jiang Y, Li Y, Wang Y, Chen Z, Wu S, Zhang Y, Wang D, Wang Y, Feigin VL (2017) Prevalence, incidence, and mortality of stroke in China: results from a Nationwide population-based survey of 480 687 adults. Circulation 135:759\u2013771","journal-title":"Circulation"},{"key":"653_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13041-018-0357-8","volume":"11","author":"QJ Wu","year":"2018","unstructured":"Wu QJ, Tymianski M (2018) Targeting NMDA receptors in stroke: new hope in neuroprotection. MOL BRAIN 11:15","journal-title":"MOL BRAIN"},{"key":"653_CR13","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1161\/STROKEAHA.118.022001","volume":"49","author":"S Wu","year":"2018","unstructured":"Wu S, Yuan R, Wang Y, Wei C, Zhang S, Yang X, Wu B, Liu M (2018) Early prediction of malignant brain edema after ischemic stroke. STROKE 49:2918\u20132927","journal-title":"STROKE"},{"key":"653_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1248\/cpb.c18-00806","volume":"67","author":"SP Wu","year":"2019","unstructured":"Wu SP, Li D, Wang N, Hou JC, Zhao L (2019) YiQi Tongluo granule against cerebral ischemia\/reperfusion injury in rats by freezing GluN2B and CaMK II through NMDAR\/ERK1\/2 signaling. Chem Pharm Bull (Tokyo) 67:244\u2013252","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"653_CR15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1161\/STROKEAHA.113.001238","volume":"44","author":"G Xu","year":"2013","unstructured":"Xu G, Ma M, Liu X, Hankey GJ (2013) Is there a stroke belt in China and why? STROKE 44:1775\u20131783","journal-title":"STROKE"},{"key":"653_CR16","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1161\/STROKEAHA.110.586669","volume":"41","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, Yao Z, D'Souza W, Zhu C, Chun H, Zhuoga C, Zhang Q, Hu X, Zhou D (2010) An epidemiological survey of stroke in Lhasa, Tibet, China. STROKE 41:2739\u20132743","journal-title":"STROKE"},{"key":"653_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bbr.2019.03.047","volume":"367","author":"M Zhu","year":"2019","unstructured":"Zhu M, Xu M, Zhang K, Li J, Ma H, Xia G, Li X, Zhang B, Shi H (2019) Effect of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley rats. Behav Brain Res 367:82\u201390","journal-title":"Behav Brain Res"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-020-00653-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-020-00653-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-020-00653-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:28:42Z","timestamp":1697516922000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-020-00653-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["653"],"URL":"https:\/\/doi.org\/10.1007\/s11011-020-00653-9","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"4 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures of animal handling were approved by the Ethics Committee for Experimental Research at Xizang Minzu University, and conformed to the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}