{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:23:18Z","timestamp":1793035398690,"version":"4.5.0"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2018\/SKK08\/IMU\/02\/2I"],"award-info":[{"award-number":["FRGS\/1\/2018\/SKK08\/IMU\/02\/2I"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11011-021-00737-0","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T08:05:18Z","timestamp":1618992318000},"page":"1087-1100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Endosomal\u2010lysosomal dysfunctions in Alzheimer\u2019s disease: Pathogenesis and therapeutic interventions"],"prefix":"10.1007","volume":"36","author":[{"given":"Shereen Shi Min","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuen Yen","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhun Yian","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Chung","family":"Chok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soi Moi","family":"Chye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"737_CR1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/s0306-4522(00)00281-5","volume":"100","author":"E Adamec","year":"2000","unstructured":"Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA (2000) Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer\u2019s disease. Neuroscience 100:663\u2013675. https:\/\/doi.org\/10.1016\/s0306-4522(00)00281-5","journal-title":"Neuroscience"},{"key":"737_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuron.2008.06.018","volume":"59","author":"PA Adlard","year":"2008","unstructured":"Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Irene Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, Deleva K, Lynch T, Kok G, Ritchie CW, Tanzi RE, Cappai R, Masters CL, Barnham KJ, Bush AI (2008) Rapid restoration of cognition in Alzheimer\u2019s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 59:43\u201355. https:\/\/doi.org\/10.1016\/j.neuron.2008.06.018","journal-title":"Neuron"},{"key":"737_CR3","doi-asserted-by":"publisher","first-page":"9871","DOI":"10.1096\/fj.201802669RR","volume":"33","author":"MJ Alldred","year":"2019","unstructured":"Alldred MJ, Chao HM, Lee SH, Beilin J, Powers BE, Petkova E, Strupp BJ, Ginsberg SD (2019) Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer\u2019s disease. FASEB J 33:9871\u20139884. https:\/\/doi.org\/10.1096\/fj.201802669RR","journal-title":"FASEB J"},{"key":"737_CR4","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","volume":"26","author":"CG Almeida","year":"2006","unstructured":"Almeida CG, Takahashi RH, Gouras GK (2006) Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26:4277\u20134288. https:\/\/doi.org\/10.1523\/JNEUROSCI.5078-05.2006","journal-title":"J Neurosci"},{"key":"737_CR5","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S1474-4422(15)00153-2","volume":"14","author":"S Andrieu","year":"2015","unstructured":"Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B (2015) Prevention of sporadic Alzheimer\u2019s disease: lessons learned from clinical trials and future directions. Lancet Neurol 14:926\u2013944. https:\/\/doi.org\/10.1016\/S1474-4422(15)00153-2","journal-title":"Lancet Neurol"},{"key":"737_CR6","doi-asserted-by":"publisher","first-page":"9428","DOI":"10.1021\/bi800993c","volume":"47","author":"AJ Beel","year":"2008","unstructured":"Beel AJ, Mobley CK, Kim HJ, Tian F, Hadziselimovic A, Jap B, Prestegard JH, Sanders CR (2008) Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry 47:9428\u20139446. https:\/\/doi.org\/10.1021\/bi800993c","journal-title":"Biochemistry"},{"key":"737_CR7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.bbalip.2010.03.008","volume":"1801","author":"AJ Beel","year":"2010","unstructured":"Beel AJ, Sakakura M, Barrett PJ, Sanders CR (2010) Direct binding of cholesterol to the amyloid precursor protein: an important interaction in lipid-Alzheimer\u2019s disease relationships? Biochim Biophys Acta 1801:975\u2013982. https:\/\/doi.org\/10.1016\/j.bbalip.2010.03.008","journal-title":"Biochim Biophys Acta"},{"key":"737_CR8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.31887\/DCNS.2009.11.3\/mbelanger","volume":"11","author":"M B\u00e9langer","year":"2009","unstructured":"B\u00e9langer M, Magistretti PJ (2009) The role of astroglia in neuroprotection. Dialogues Clin Neurosci 11:281\u2013295. https:\/\/doi.org\/10.31887\/DCNS.2009.11.3\/mbelanger","journal-title":"Dialogues Clin Neurosci"},{"key":"737_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.critrevonc.2008.02.008","volume":"68","author":"P Benes","year":"2008","unstructured":"Benes P, Vetvicka V, Fusek M (2008) Cathepsin D\u2014Many functions of one aspartic protease. Crit Rev Oncol Hematol 68:12\u201328. https:\/\/doi.org\/10.1016\/j.critrevonc.2008.02.008","journal-title":"Crit Rev Oncol Hematol"},{"key":"737_CR10","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1582-4934.2009.00609.x","volume":"13","author":"PR Bharadwaj","year":"2009","unstructured":"Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IG (2009) Abeta aggregation and possible implications in Alzheimer\u2019s disease pathogenesis. J Cell Mol Med 13:412\u2013421. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00609.x","journal-title":"J Cell Mol Med"},{"key":"737_CR11","doi-asserted-by":"publisher","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","volume":"28","author":"B Boland","year":"2008","unstructured":"Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer\u2019s disease. J Neurosci 28:6926\u20136937. https:\/\/doi.org\/10.1523\/JNEUROSCI.0800-08.2008","journal-title":"J Neurosci"},{"key":"737_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1083\/jcb.201310021","volume":"204","author":"JS Bonifacino","year":"2014","unstructured":"Bonifacino JS (2014) Adaptor proteins involved in polarized sorting. J Cell Biol 204:7\u201317. https:\/\/doi.org\/10.1083\/jcb.201310021","journal-title":"J Cell Biol"},{"key":"737_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","volume":"72","author":"JS Bonifacino","year":"2003","unstructured":"Bonifacino JS, Traub LM (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 72:395\u2013447. https:\/\/doi.org\/10.1146\/annurev.biochem.72.121801.161800","journal-title":"Annu Rev Biochem"},{"key":"737_CR14","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1080\/15548627.2016.1239003","volume":"12","author":"M Bordi","year":"2016","unstructured":"Bordi M, Berg M, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA (2016) Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy 12:2467\u20132483. https:\/\/doi.org\/10.1080\/15548627.2016.1239003","journal-title":"Autophagy"},{"key":"737_CR15","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s11064-020-03223-8","volume":"46","author":"B Cao","year":"2021","unstructured":"Cao B, Zeng M, Zhang Q, Zhang B, Cao Y, Wu Y, Feng W, Zheng X (2021) Amentoflavone ameliorates memory deficits and abnormal autophagy in A\u03b2 25 \u2013 35-induced mice by mTOR signaling. Neurochem Res 46:921\u2013934. https:\/\/doi.org\/10.1007\/s11064-020-03223-8","journal-title":"Neurochem Res"},{"key":"737_CR16","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1523\/JNEUROSCI.17-16-06142.1997","volume":"17","author":"AM Cataldo","year":"1997","unstructured":"Cataldo AM, Barnett JL, Pieroni C, Nixon RA (1997) Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer\u2019s disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J Neurosc 17:6142\u20136151. https:\/\/doi.org\/10.1523\/JNEUROSCI.17-16-06142.1997","journal-title":"J Neurosc"},{"issue":"10","key":"737_CR17","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.neurobiolaging.2004a.02.027","volume":"25","author":"A Cataldo","year":"2004","unstructured":"Cataldo A, Petanceska S, Terio N, Peterhoff C, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA (2004) Abeta localization in abnormal endosomes: association with earliest A\u03b2 elevations in AD and Down syndrome. Neurobiol Aging 25(10):1263\u20131272. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2004a.02.027","journal-title":"Neurobiol Aging"},{"key":"737_CR18","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1093\/jnen\/63.8.821","volume":"63","author":"AM Cataldo","year":"2004","unstructured":"Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA (2004) Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 63:821\u2013830. https:\/\/doi.org\/10.1093\/jnen\/63.8.821","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"737_CR19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2353\/ajpath.2008.071053","volume":"173","author":"A Cataldo","year":"2008","unstructured":"Cataldo A, Mathews P, Boiteau A, Hassinger L, Peterhoff C, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA (2008) Down syndrome fibroblast model of alzheimer-related endosome pathology. Am J Pathol 173(2):370\u2013384. https:\/\/doi.org\/10.2353\/ajpath.2008.071053","journal-title":"Am J Pathol"},{"issue":"4","key":"737_CR20","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1096\/fj.201700692RR","volume":"32","author":"M Caudill","year":"2018","unstructured":"Caudill M, Strupp B, Muscalu L, Nevins J, Canfield R (2018) Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB J 32(4):2172\u20132180. https:\/\/doi.org\/10.1096\/fj.201700692RR","journal-title":"FASEB J"},{"key":"737_CR21","doi-asserted-by":"publisher","unstructured":"Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, Sun Q, Yi C, Wu J, Najafov A et al (2020) Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer\u2019s disease mouse model. Nat Commun 11. https:\/\/doi.org\/10.1038\/s41467-020-19547-6","DOI":"10.1038\/s41467-020-19547-6"},{"issue":"10","key":"737_CR22","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1038\/emboj.2012.79","volume":"31","author":"L Ch\u00e1vez-Guti\u00e9rrez","year":"2012","unstructured":"Ch\u00e1vez-Guti\u00e9rrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Cleynenbreugel SV, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, Strooper BD (2012) The mechanism of \u03b3-Secretase dysfunction in familial Alzheimer disease. EMBO J 31(10):2261\u20132274. https:\/\/doi.org\/10.1038\/emboj.2012.79","journal-title":"EMBO J"},{"key":"737_CR23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fncel.2015.00186","volume":"9","author":"M Chen","year":"2015","unstructured":"Chen M (2015) The maze of APP processing in Alzheimer\u2019s disease: Where did we go wrong in reasoning? Front Cell Neurosci 9:186. https:\/\/doi.org\/10.3389\/fncel.2015.00186","journal-title":"Front Cell Neurosci"},{"key":"737_CR24","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.7150\/thno.47408","volume":"11","author":"ML Chen","year":"2021","unstructured":"Chen ML, Hong CG, Yue T, Li HM, Duan R, Hu WB, Cao J, Wang ZX, Chen CY, Hu XK et al (2021) Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer\u2019s disease by enhancing autophagy. Theranostics 11:2395\u20132409. https:\/\/doi.org\/10.7150\/thno.47408","journal-title":"Theranostics"},{"key":"737_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuron.2014.02.018","volume":"82","author":"RWY Choy","year":"2014","unstructured":"Choy RWY, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M (2014) Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron 82:55\u201362. https:\/\/doi.org\/10.1016\/j.neuron.2014.02.018","journal-title":"Neuron"},{"key":"737_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neurobiolaging.2016.12.025","volume":"52","author":"J Chu","year":"2017","unstructured":"Chu J, Pratic\u00f2 D (2017) The retromer complex system in a transgenic mouse model of AD: influence of age. Neurobiol Aging 52:32\u201338. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.12.025","journal-title":"Neurobiol Aging"},{"key":"737_CR27","doi-asserted-by":"publisher","unstructured":"Chu F, Li K, Li X, Xu L, Huang J, Yang Z (2021) Graphene oxide ameliorates the cognitive impairment through inhibiting PI3K\/Akt\/mTOR pathway to induce autophagy in AD mouse model. Neurochem Res 46:309\u2013325. https:\/\/doi.org\/10.1007\/s11064-020-03167-z","DOI":"10.1007\/s11064-020-03167-z"},{"key":"737_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuroscience.2014.01.001","volume":"263","author":"EE Coffey","year":"2014","unstructured":"Coffey EE, Beckel JM, Laties AM, Mitchell CH (2014) Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer\u2019s disease-linked presenilin 1 A246E mutation can be reversed with cAMP. Neuroscience 263:111\u2013124. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.01.001","journal-title":"Neuroscience"},{"key":"737_CR29","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2017.10.001","volume":"114","author":"D Colacurcio","year":"2018","unstructured":"Colacurcio D, Pensalfini A, Jiang Y, Nixon R (2018) Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer\u2019s Disease. Free Radic Biol Med 114:40\u201351. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.10.001","journal-title":"Free Radic Biol Med"},{"key":"737_CR30","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1038\/cddis.2010.73","volume":"1","author":"C Corona","year":"2010","unstructured":"Corona C, Masciopinto F, Silvestri E, Viscovo AD, Lattanzio R, Sorda RL, Ciavardelli D, Goglia F, Piantelli M, Canzoniero LMT, Sensi SL (2010) Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction. Cell Death Dis 1:e91. https:\/\/doi.org\/10.1038\/cddis.2010.73","journal-title":"Cell Death Dis"},{"key":"737_CR31","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.bbalip.2010.03.010","volume":"1801","author":"J Cossec","year":"2010","unstructured":"Cossec J, Marquer C, Panchal M, Lazar A, Duyckaerts C, Potier M (2010) Cholesterol changes in Alzheimer\u2019s disease: methods of analysis and impact on the formation of enlarged endosomes. Biochim Biophys Acta 1801:839\u2013845. https:\/\/doi.org\/10.1016\/j.bbalip.2010.03.010","journal-title":"Biochim Biophys Acta"},{"key":"737_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nn.4188","volume":"19","author":"U Das","year":"2015","unstructured":"Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S (2015) Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci 19:55\u201364. https:\/\/doi.org\/10.1038\/nn.4188","journal-title":"Nat Neurosci"},{"key":"737_CR33","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.jnutbio.2015.03.004","volume":"26","author":"C Davenport","year":"2015","unstructured":"Davenport C, Yan J, Taesuwan S, Shields K, West AA, Jiang X, Perry CA, Malysheva OV, Stabler SP, Allen RH, Caudill MA (2015) Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites. J Nutr Biochem 26:903\u2013911. https:\/\/doi.org\/10.1016\/j.jnutbio.2015.03.004","journal-title":"J Nutr Biochem"},{"key":"737_CR34","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3389\/fphys.2013.00412","volume":"4","author":"GH Diering","year":"2014","unstructured":"Diering GH, Numata M (2014) Endosomal pH in neuronal signaling and synaptic transmission: role of Na+\/H + exchanger NHE5. Front Physiol 4:412. https:\/\/doi.org\/10.3389\/fphys.2013.00412","journal-title":"Front Physiol"},{"key":"737_CR35","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.bbadis.2013.04.013\/","volume":"1832","author":"FD Domenico","year":"2013","unstructured":"Domenico FD, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M (2013) Impairment of proteostasis network in down syndrome prior to the development of Alzheimer\u2019s disease neuropathology: Redox proteomics analysis of human brain. Biochim Biophys Acta 1832:1249\u20131259. https:\/\/doi.org\/10.1016\/j.bbadis.2013.04.013\/","journal-title":"Biochim Biophys Acta"},{"key":"737_CR36","doi-asserted-by":"publisher","unstructured":"Duan L, Hu M, Tamm JA, Grinberg YY, Shen F, Chai Y, Xi H, Gibilisco L, Ravikumar B, Gautam V et al (2021) Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer\u2019s disease model. Sci Rep 1. https:\/\/doi.org\/10.1038\/s41598-021-82658-7","DOI":"10.1038\/s41598-021-82658-7"},{"key":"737_CR37","doi-asserted-by":"publisher","unstructured":"Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003) Reconstitution of gamma -secretase activity. Nat Cell Biol 5:486\u2013488. https:\/\/doi.org\/10.1038\/ncb960","DOI":"10.1038\/ncb960"},{"issue":"6","key":"737_CR38","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.chembiol.2014.03.014","volume":"21","author":"EK Esbj\u00f6rner","year":"2014","unstructured":"Esbj\u00f6rner EK, Chan F, Rees E, Erdelyi M, Luheshi LM, Bertoncini CW, Kaminski CF, Dobson CM, Schierle GSK (2014) Direct observations of amyloid \u03b2 self-assembly in live cells provide insights into differences in the kinetics of A\u03b2(1\u201340) and A\u03b2(1\u201342) aggregation. Chem Biol 21(6):732\u2013742. https:\/\/doi.org\/10.1016\/j.chembiol.2014.03.014","journal-title":"Chem Biol"},{"key":"737_CR39","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X et al (2019) Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nat Neurosci 22:401\u2013412. https:\/\/doi.org\/10.1038\/s41593-018-0332-9","journal-title":"Nat Neurosci"},{"key":"737_CR40","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1582-4934.2008.00314.x","volume":"12","author":"D Farfara","year":"2008","unstructured":"Farfara D, Lifshitz V, Frenkel D (2008) Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer\u2019s disease. J Cell Mol Med 12:762\u2013780. https:\/\/doi.org\/10.1111\/j.1582-4934.2008.00314.x","journal-title":"J Cell Mol Med"},{"key":"737_CR41","doi-asserted-by":"publisher","first-page":"5856","DOI":"10.1073\/pnas.081620098","volume":"98","author":"K Fassbender","year":"2001","unstructured":"Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T (2001) Simvastatin strongly reduces levels of Alzheimer\u2019s disease - amyloid peptides A 42 and A 40 in vitro and in vivo. Proc Natl Acad Sci U S A 98:5856\u20135861. https:\/\/doi.org\/10.1073\/pnas.081620098","journal-title":"Proc Natl Acad Sci U S A"},{"key":"737_CR42","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3390\/ijms18020252","volume":"18","author":"AB Ganz","year":"2017","unstructured":"Ganz AB, Cohen VV, Swersky CC, Stover J, Vitiello GA, Lovesky J, Chuang JC, Shields K, Fomin VG, Lopez YS, Mohan S, Ganti A, Carrier B, Malysheva OV, Caudill MA (2017) Genetic variation in choline-metabolizing enzymes alters choline metabolism in young women consuming choline intakes meeting current recommendations. Int J Mol Sci 18:252. https:\/\/doi.org\/10.3390\/ijms18020252","journal-title":"Int J Mol Sci"},{"key":"737_CR43","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.neurobiolaging.2009.11.006","volume":"32","author":"S George","year":"2011","unstructured":"George S, Mufson EJ, Leurgans S, Shah RC, Ferrari C, deToledo-Morrell L (2011) MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobio Aging 32:1756\u20131764. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.11.006","journal-title":"Neurobio Aging"},{"key":"737_CR44","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","volume":"112","author":"S Ghavami","year":"2014","unstructured":"Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, Christoffersson J, Chaabane W, Moghadam AR, Kashani HH, Hashemi M, Owji AA, \u0141os MJ (2014) Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol 112:24\u201349. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.10.004","journal-title":"Prog Neurobiol"},{"issue":"28","key":"737_CR45","doi-asserted-by":"publisher","first-page":"E3699","DOI":"10.1073\/pnas.1510329112","volume":"112","author":"S Gowrishankar","year":"2015","unstructured":"Gowrishankar S, Yuan P, Wu Y et al (2015) Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer\u2019s disease amyloid plaques. Proc Natl Acad Sci U S A 112(28):E3699\u2013E3708. https:\/\/doi.org\/10.1073\/pnas.1510329112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"737_CR46","doi-asserted-by":"publisher","first-page":"31261","DOI":"10.1074\/jbc.M304122200","volume":"278","author":"OM Grbovic","year":"2003","unstructured":"Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM (2003) Rab5 stimulated pp-regulation of the endocytic pathway increases intracellular \u03b2-cleaved amyloid precursor protein carboxyl-terminal fragment levels and A\u03b2 production. J Biol Chem 278:31261\u201331268. https:\/\/doi.org\/10.1074\/jbc.M304122200","journal-title":"J Biol Chem"},{"key":"737_CR47","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.biopsych.2011.06.019","volume":"71","author":"M Grothe","year":"2012","unstructured":"Grothe M, Heinsen H, Teipel SJ (2012) Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer\u2019s disease. Bio Psychiatry 71:805\u2013813. https:\/\/doi.org\/10.1016\/j.biopsych.2011.06.019","journal-title":"Bio Psychiatry"},{"key":"737_CR48","doi-asserted-by":"publisher","first-page":"6018","DOI":"10.3390\/molecules25246018","volume":"25","author":"R Gruendler","year":"2020","unstructured":"Gruendler R, Hippe B, Jengic S, Peterlin V, Haslberger AG (2020) Nutraceutical approaches of autophagy and neuroinflammation in Alzheimer\u2019s disease: a systematic review. Molecules 25:6018. https:\/\/doi.org\/10.3390\/molecules25246018","journal-title":"Molecules"},{"key":"737_CR49","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1091\/mbc.11.12.4105","volume":"11","author":"CR Haft","year":"2000","unstructured":"Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (2000) Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell 11:4105\u20134116. https:\/\/doi.org\/10.1091\/mbc.11.12.4105","journal-title":"Mol Biol Cell"},{"key":"737_CR50","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1523\/JNEUROSCI.19-04-01324.1999","volume":"19","author":"CD Hazuka","year":"1999","unstructured":"Hazuka CD, Foletti DL, Hsu SC, Kee Y, Hopf FW, Scheller RH (1999) The Sec. 6\/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci 19:1324\u20131334. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-04-01324.1999","journal-title":"J Neurosci"},{"key":"737_CR51","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1523\/JNEUROSCI.5209-10.2011","volume":"31","author":"J Hongpaisan","year":"2011","unstructured":"Hongpaisan J, Sun MK, Alkon DL (2011) PKC activation prevents synaptic loss, an elevation, and cognitive deficits in Alzheimer\u2019s disease transgenic mice. J Neurosci 31:630\u2013643. https:\/\/doi.org\/10.1523\/JNEUROSCI.5209-10.2011","journal-title":"J Neurosci"},{"key":"737_CR52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/neu.10323","volume":"58","author":"CL Howe","year":"2003","unstructured":"Howe CL, Mobley WC (2003) Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobio 58:207\u2013216. https:\/\/doi.org\/10.1002\/neu.10323","journal-title":"J Neurobio"},{"key":"737_CR53","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.neuron.2006.10.035","volume":"52","author":"H Hsieh","year":"2006","unstructured":"Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R (2006) AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52:831\u2013843. https:\/\/doi.org\/10.1016\/j.neuron.2006.10.035","journal-title":"Neuron"},{"key":"737_CR54","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ceb.2010.05.008","volume":"22","author":"VW Hsu","year":"2010","unstructured":"Hsu VW, Prekeris R (2010) Transport at the recycling endosome. Curr Opin Cell Biol 22:528\u2013534. https:\/\/doi.org\/10.1016\/j.ceb.2010.05.008","journal-title":"Curr Opin Cell Biol"},{"key":"737_CR55","doi-asserted-by":"publisher","first-page":"20324","DOI":"10.1073\/pnas.0911281106","volume":"106","author":"X Hu","year":"2009","unstructured":"Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci U S A 106:20324\u201320329. https:\/\/doi.org\/10.1073\/pnas.0911281106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"737_CR56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40035-015-0041-1","volume":"4","author":"YB Hu","year":"2015","unstructured":"Hu YB, Dammer EB, Ren RJ, Wang G (2015) The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration. Transl Neurodegener 4:18. https:\/\/doi.org\/10.1186\/s40035-015-0041-1","journal-title":"Transl Neurodegener"},{"key":"737_CR57","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.molmed.2010.04.004","volume":"16","author":"Y Huang","year":"2010","unstructured":"Huang Y (2010) Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer\u2019s disease. Trends Mol Med 16:287\u2013294. https:\/\/doi.org\/10.1016\/j.molmed.2010.04.004","journal-title":"Trends Mol Med"},{"key":"737_CR58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1567205012666150921100030","volume":"13","author":"MF Iulita","year":"2015","unstructured":"Iulita MF, Cuello AC (2015) The NGF metabolic pathway in the CNS and its dysregulation in down syndrome and Alzheimer\u2019s disease. Curr Alzheimer Res 13:53\u201367. https:\/\/doi.org\/10.2174\/1567205012666150921100030","journal-title":"Curr Alzheimer Res"},{"key":"737_CR59","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13024-017-0197-5","volume":"12","author":"TR Jay","year":"2017","unstructured":"Jay TR, von Saucken VE, Landreth GE (2017) TREM2 in neurodegenerative diseases. Mol Neurodegener 12:56. https:\/\/doi.org\/10.1186\/s13024-017-0197-5","journal-title":"Mol Neurodegener"},{"key":"737_CR60","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1074\/jbc.M506646200","volume":"281","author":"ZS Ji","year":"2005","unstructured":"Ji ZS, M\u00fcllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW (2005) Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration. J Biol Chem 281:2683\u20132692. https:\/\/doi.org\/10.1074\/jbc.M506646200","journal-title":"J Biol Chem"},{"key":"737_CR61","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.bbamem.2013.04.016","volume":"1828","author":"N Jurisch-Yaksi","year":"2013","unstructured":"Jurisch-Yaksi N, Sannerud R, Annaert W (2013) A fast-growing spectrum of biological functions of \u03b3-secretase in development and disease. Biochim Biophys Acta 1828:2815\u20132827. https:\/\/doi.org\/10.1016\/j.bbamem.2013.04.016","journal-title":"Biochim Biophys Acta"},{"key":"737_CR62","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s0092-8674(01)00434-2","volume":"106","author":"DJ Katzmann","year":"2001","unstructured":"Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106:145\u2013155. https:\/\/doi.org\/10.1016\/s0092-8674(01)00434-2","journal-title":"Cell"},{"issue":"3","key":"737_CR63","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.neuron.2009.01.015","volume":"61","author":"HW Kessels","year":"2009","unstructured":"Kessels HW, Malinow R (2009) Synaptic AMPA receptor plasticity and behavior. Neuron 61(3):340\u2013350. https:\/\/doi.org\/10.1016\/j.neuron.2009.01.015","journal-title":"Neuron"},{"key":"737_CR64","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3233\/JAD-2012-111604","volume":"29","author":"MS Kindy","year":"2012","unstructured":"Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook G (2012) Deletion of the cathepsin B gene improves memory deficits in a transgenic Alzeimer\u2019s disease mouse model expressing A\u03b2PP containing the wild-type \u03b2-secretase site sequence. J Alzheimers Dis 29:827\u2013840. https:\/\/doi.org\/10.3233\/JAD-2012-111604","journal-title":"J Alzheimers Dis"},{"key":"737_CR65","doi-asserted-by":"publisher","first-page":"243ra86","DOI":"10.1126\/scitranslmed.3009093","volume":"6","author":"G Kleinberger","year":"2014","unstructured":"Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lle\u00f3 A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, S\u00e1nchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Broeckhoven CV, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C (2014) TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 6:243ra86. https:\/\/doi.org\/10.1126\/scitranslmed.3009093","journal-title":"Sci Transl Med"},{"key":"737_CR66","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/j.cellsig.2006.04.006","volume":"18","author":"CHV Koh","year":"2006","unstructured":"Koh CHV, Cheung NS (2006) Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer\u2019s disease. Cell Signal 18:1844\u20131853. https:\/\/doi.org\/10.1016\/j.cellsig.2006.04.006","journal-title":"Cell Signal"},{"key":"737_CR67","doi-asserted-by":"publisher","unstructured":"Koh JY, Kim HN, Hwang JJ, Kim YH, Park SE (2019) Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc. Mol Brain 12(1). https:\/\/doi.org\/10.1186\/s13041-019-0439-2","DOI":"10.1186\/s13041-019-0439-2"},{"key":"737_CR68","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/j.neurobiolaging.2011.11.009","volume":"33","author":"U Kr\u00fcger","year":"2012","unstructured":"Kr\u00fcger U, Wang Y, Kumar S, Mandelkow EM (2012) Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging 33:2291\u20132305. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.11.009","journal-title":"Neurobiol Aging"},{"key":"737_CR69","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/bies.201200130","volume":"35","author":"CA Lamb","year":"2013","unstructured":"Lamb CA, Dooley HC, Tooze SA (2013) Endocytosis and autophagy: Shared machinery for degradation. Bioessays 35:34\u201345. https:\/\/doi.org\/10.1002\/bies.201200130","journal-title":"Bioessays"},{"issue":"21","key":"737_CR70","doi-asserted-by":"publisher","first-page":"7817","DOI":"10.1523\/JNEUROSCI.6412-10.2011","volume":"31","author":"S Lee","year":"2011","unstructured":"Lee S, Sato Y, Nixon RA (2011) Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer\u2019s-like axonal dystrophy. J Neurosci 31(21):7817\u20137830. https:\/\/doi.org\/10.1523\/JNEUROSCI.6412-10.2011","journal-title":"J Neurosci"},{"key":"737_CR71","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.nbd.2015.03.015","volume":"81","author":"P Lei","year":"2015","unstructured":"Lei P, Ayton S, Appukuttan AT, Volitakis I, Adlard PA, Finkelstein DI, Bush AI (2015) Clioquinol rescues parkinsonism and dementia phenotypes of the tau knockout mouse. Neurobiol Dis 81:168\u2013175. https:\/\/doi.org\/10.1016\/j.nbd.2015.03.015","journal-title":"Neurobiol Dis"},{"key":"737_CR72","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.pneurobio.2011.10.002","volume":"97","author":"X Li","year":"2012","unstructured":"Li X, DiFiglia M (2012) The recycling endosome and its role in neurological disorders. Prog Neurobiol 97:127\u2013141. https:\/\/doi.org\/10.1016\/j.pneurobio.2011.10.002","journal-title":"Prog Neurobiol"},{"key":"737_CR73","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.biocel.2014.11.001","volume":"58","author":"A Magini","year":"2015","unstructured":"Magini A, Polchi A, Tozzi A, Tancini B, Tantucci M, Urbanelli L, Borsello T, Calabresi P, Emiliani C (2015) Abnormal cortical lysosomal \u03b2-hexosaminidase and \u03b2-galactosidase activity at post-synaptic sites during Alzheimer\u2019s disease progression. Int J Biochem Cell Biol 58:62\u201370. https:\/\/doi.org\/10.1016\/j.biocel.2014.11.001","journal-title":"Int J Biochem Cell Biol"},{"key":"737_CR74","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0925-4439(99)00074-5","volume":"1455","author":"DJ Mahuran","year":"1999","unstructured":"Mahuran DJ (1999) Biochemical consequences of mutations causing the GM2 gangliosidoses. Biochim Biophys Acta 1455:105\u2013138. https:\/\/doi.org\/10.1016\/s0925-4439(99)00074-5","journal-title":"Biochim Biophys Acta"},{"key":"737_CR75","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.bbalip.2010.03.011","volume":"1801","author":"M Martin","year":"2010","unstructured":"Martin M, Dotti CG, Ledesma MD (2010) Brain cholesterol in normal and pathological aging. Biochim Biophys Acta 1801:934\u2013944. https:\/\/doi.org\/10.1016\/j.bbalip.2010.03.011","journal-title":"Biochim Biophys Acta"},{"key":"737_CR76","doi-asserted-by":"publisher","first-page":"a006262","DOI":"10.1101\/cshperspect.a006262","volume":"2","author":"CL Masters","year":"2012","unstructured":"Masters CL, Selkoe DJ (2012) Biochemistry of amyloid - protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med 2:a006262\u2013a006262. https:\/\/doi.org\/10.1101\/cshperspect.a006262","journal-title":"Cold Spring Harb Perspect Med"},{"key":"737_CR77","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1074\/jbc.M108161200","volume":"277","author":"PM Mathews","year":"2001","unstructured":"Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA (2001) Alzheimer\u2019s disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. J Biol Chem 277:5299\u20135307. https:\/\/doi.org\/10.1074\/jbc.M108161200","journal-title":"J Biol Chem"},{"key":"737_CR78","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1111\/j.1600-0854.2011.01201.x","volume":"12","author":"IJ McGough","year":"2011","unstructured":"McGough IJ, Cullen PJ (2011) Recent advances in retromer biology. Traffic 12:963\u2013971. https:\/\/doi.org\/10.1111\/j.1600-0854.2011.01201.x","journal-title":"Traffic"},{"key":"737_CR79","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2741\/4506","volume":"22","author":"C McGuire","year":"2017","unstructured":"McGuire C, Stransky L, Cotter K, Forgac M (2017) Regulation of V-ATPase activity. Front Biosci 22:609\u2013622. https:\/\/doi.org\/10.2741\/4506","journal-title":"Front Biosci"},{"key":"737_CR80","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nchembio.1508","volume":"10","author":"VJ Mecozzi","year":"2014","unstructured":"Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA (2014) Pharmacological chaperones stabilize retromer to limit APP processing. Nature Chem Biol 10:443\u2013449. https:\/\/doi.org\/10.1038\/nchembio.1508","journal-title":"Nature Chem Biol"},{"key":"737_CR81","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.expneurol.2012.10.007","volume":"239","author":"R Medeiros","year":"2013","unstructured":"Medeiros R, LaFerla FM (2013) Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony. Exp Neurol 239:133\u2013138. https:\/\/doi.org\/10.1016\/j.expneurol.2012.10.007","journal-title":"Exp Neurol"},{"key":"737_CR82","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.tins.2013.11.006","volume":"37","author":"J Neefjes","year":"2014","unstructured":"Neefjes J, van der Kant R (2014) Stuck in traffic: an emerging theme in diseases of the nervous system. Trends Neurosci 37:66\u201376. https:\/\/doi.org\/10.1016\/j.tins.2013.11.006","journal-title":"Trends Neurosci"},{"key":"737_CR83","doi-asserted-by":"publisher","first-page":"34514","DOI":"10.1074\/jbc.M109.016683","volume":"284","author":"T Nelson","year":"2009","unstructured":"Nelson T, Cui C, Luo Y, Alkon DL (2009) Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators. J Biol Chem 284:34514\u201334521. https:\/\/doi.org\/10.1074\/jbc.M109.016683","journal-title":"J Biol Chem"},{"key":"737_CR84","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neurobiolaging.2004.09.018","volume":"26","author":"RA Nixon","year":"2005","unstructured":"Nixon RA (2005) Endosome function and dysfunction in Alzheimer\u2019s disease and other neurodegenerative diseases. Neurobiol Aging 26:373\u2013382. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2004.09.018","journal-title":"Neurobiol Aging"},{"key":"737_CR85","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.3232","volume":"19","author":"RA Nixon","year":"2013","unstructured":"Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19:983\u2013997. https:\/\/doi.org\/10.1038\/nm.3232","journal-title":"Nat Med"},{"issue":"1","key":"737_CR86","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","volume":"43","author":"RA Nixon","year":"2011","unstructured":"Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer\u2019s disease\u2013locating the primary defect. Neurobiol Dis 43(1):38\u201345. https:\/\/doi.org\/10.1016\/j.nbd.2011.01.021","journal-title":"Neurobiol Dis"},{"key":"737_CR87","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3233\/jad-2001-3114","volume":"3","author":"RA Nixon","year":"2001","unstructured":"Nixon RA, Mathews PM, Cataldo AM (2001) The neuronal endosomal-lysosomal system in Alzheimer\u2019s disease. J Alzheimers Dis 3:97\u2013107. https:\/\/doi.org\/10.3233\/jad-2001-3114","journal-title":"J Alzheimers Dis"},{"key":"737_CR88","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/bs.ircmb.2017.07.002","volume":"336","author":"C Ntsapi","year":"2018","unstructured":"Ntsapi C, Lumkwana D, Swart C, du Toit A, Loos B (2018) New insights into autophagy dysfunction related to amyloid beta toxicity and neuropathology in Alzheimer\u2019s disease. Int Rev Cell Mol Biol 336:321\u2013361. https:\/\/doi.org\/10.1016\/bs.ircmb.2017.07.002","journal-title":"Int Rev Cell Mol Biol"},{"key":"737_CR89","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","volume":"34","author":"RJ O\u2019Brien","year":"2011","unstructured":"O\u2019Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer\u2019s disease. Ann Rev Neurosci 34:185\u2013204. https:\/\/doi.org\/10.1146\/annurev-neuro-061010-113613","journal-title":"Ann Rev Neurosci"},{"key":"737_CR90","doi-asserted-by":"publisher","unstructured":"Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M et al (2013) Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS One 8. https:\/\/doi.org\/10.1371\/journal.pone.0062459","DOI":"10.1371\/journal.pone.0062459"},{"key":"737_CR91","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1074\/jbc.M112.422964","volume":"288","author":"J Pacheco-Quinto","year":"2013","unstructured":"Pacheco-Quinto J, Eckman EA (2013) Endothelin-converting enzymes degrade intracellular \u03b2-amyloid produced within the endosomal\/lysosomal pathway and autophagosomes. J Biol Chem 288:5606\u20135615. https:\/\/doi.org\/10.1074\/jbc.M112.422964","journal-title":"J Biol Chem"},{"key":"737_CR92","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1096\/fj.201801319R","volume":"33","author":"J Pacheco-Quinto","year":"2019","unstructured":"Pacheco-Quinto J, Clausen D, P\u00e9rez-Gonz\u00e1lez R, Peng H, Meszaros A, Eckman CB, Levy E, Eckman EA (2019) Intracellular metalloprotease activity controls intraneuronal A\u03b2 aggregation and limits secretion of A\u03b2 via exosomes. FASEB J 33:3758\u20133771. https:\/\/doi.org\/10.1096\/fj.201801319R","journal-title":"FASEB J"},{"key":"737_CR93","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.nbd.2011.01.009","volume":"42","author":"MH Park","year":"2011","unstructured":"Park MH, Lee SJ, Byun HR, Kim Y, Oh YJ, Koh JY, Hwang JJ (2011) Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore. Neurobiol Dis 42:242\u2013251. https:\/\/doi.org\/10.1016\/j.nbd.2011.01.009","journal-title":"Neurobiol Dis"},{"key":"737_CR94","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/NEN.0000000000000179","volume":"74","author":"SE Perez","year":"2015","unstructured":"Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ (2015) Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with a\u03b2 and tau pathology. J Neuropathol Exp Neurol 74:345\u2013358. https:\/\/doi.org\/10.1097\/NEN.0000000000000179","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"737_CR95","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11011-018-0214-6","volume":"33","author":"K Pierzynowska","year":"2018","unstructured":"Pierzynowska K, Gaffke L, Cyske Z et al (2018) Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases. Metab Brain Dis 33(4):989\u20131008. https:\/\/doi.org\/10.1007\/s11011-018-0214-6","journal-title":"Metab Brain Dis"},{"key":"737_CR96","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.neuropharm.2019.01.030","volume":"148","author":"K Pierzynowska","year":"2019","unstructured":"Pierzynowska K, Podlacha M, Gaffke L, Majkutewicz I, Mantej J, W\u0119grzyn A, Osiad\u0142y M, My\u015bli\u0144ska D, W\u0119grzyn G (2019) Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer\u2019s disease. Neuropharmacology 148:332\u2013346. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.01.030","journal-title":"Neuropharmacology"},{"key":"737_CR97","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cell.2010.03.011","volume":"141","author":"D Poteryaev","year":"2010","unstructured":"Poteryaev D, Datta S, Ackema K, Zerial M, Spang A (2010) Identification of the switch in early-to-late endosome transition. Cell 141:497\u2013508. https:\/\/doi.org\/10.1016\/j.cell.2010.03.011","journal-title":"Cell"},{"key":"737_CR98","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","volume":"9","author":"M Prince","year":"2013","unstructured":"Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 9:63\u201375. https:\/\/doi.org\/10.1016\/j.jalz.2012.11.007","journal-title":"Alzheimers Dement"},{"key":"737_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biomedicines9010005","volume":"9","author":"MA Rahman","year":"2021","unstructured":"Rahman MA, Rahman MS, Rahman MH, Rasheduzzaman M, Mamun-Or-rashid ANM, Uddin MJ, Rahman MR, Hwang H, Pang MG, Rhim H (2021) Modulatory effects of autophagy on app processing as a potential treatment target for alzheimer\u2019s disease. Biomedicines 9:1\u201320. https:\/\/doi.org\/10.3390\/biomedicines9010005","journal-title":"Biomedicines"},{"key":"737_CR100","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature07961","volume":"458","author":"C Raiborg","year":"2009","unstructured":"Raiborg C, Stenmark H (2009) The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458:445\u2013452. https:\/\/doi.org\/10.1038\/nature07961","journal-title":"Nature"},{"key":"737_CR101","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/j.1600-0854.2012.01332.x","volume":"13","author":"L Rajendran","year":"2012","unstructured":"Rajendran L, Annaert W (2012) Membrane trafficking pathways in Alzheimer\u2019s disease. Traffic 13:759\u2013770. https:\/\/doi.org\/10.1111\/j.1600-0854.2012.01332.x","journal-title":"Traffic"},{"key":"737_CR102","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1126\/science.1156609","volume":"320","author":"L Rajendran","year":"2008","unstructured":"Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, Schwille P, Schulz JB, Schroeder C, Simons M, Jennings G, Kn\u00f6lker HJ, Simons K (2008) Efficient inhibition of the Alzheimer\u2019s disease beta-secretase by membrane targeting. Science 320:520\u2013523. https:\/\/doi.org\/10.1126\/science.1156609","journal-title":"Science"},{"key":"737_CR103","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fnmol.2016.00130","volume":"9","author":"JM Ramaker","year":"2016","unstructured":"Ramaker JM, Cargill RS, Swanson TL, Quirindongo H, Cassar M, Kretzschmar D, Copenhaver PF (2016) Amyloid precursor proteins are dynamically trafficked and processed during neuronal development. Front Mol Neurosci 9:130. https:\/\/doi.org\/10.3389\/fnmol.2016.00130","journal-title":"Front Mol Neurosci"},{"key":"737_CR104","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1006\/nbdi.2001.0422","volume":"8","author":"LM Refolo","year":"2001","unstructured":"Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, Duff KE (2001) A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer\u2019s disease. Neurobiol Dis 8:890\u2013899. https:\/\/doi.org\/10.1006\/nbdi.2001.0422","journal-title":"Neurobiol Dis"},{"key":"737_CR105","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cell.2016.05.020","volume":"166","author":"R Sannerud","year":"2016","unstructured":"Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, Baets GD, Wever VD, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Niel GV, Strooper BD, Annaert W (2016) Restricted location of PSEN2\/\u03b3-secretase determines substrate specificity and generates an intracellular A\u03b2 pool. Cell 166:193\u2013208. https:\/\/doi.org\/10.1016\/j.cell.2016.05.020","journal-title":"Cell"},{"key":"737_CR106","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.bbr.2008.02.016","volume":"192","author":"DJ Selkoe","year":"2008","unstructured":"Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plastivity and behaviour. Behav Brain Res 192:106\u2013113. https:\/\/doi.org\/10.1016\/j.bbr.2008.02.016","journal-title":"Behav Brain Res"},{"key":"737_CR107","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1016\/j.neurobiolaging.2015.09.006","volume":"36","author":"BR Seo","year":"2015","unstructured":"Seo BR, Lee SJ, Cho KS, Yoon YH, Koh JY (2015) The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP\/mutant presenilin-1-transfected Chinese hamster ovary cells. Neurobiol Aging 36:3228\u20133238. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.09.006","journal-title":"Neurobiol Aging"},{"key":"737_CR108","doi-asserted-by":"publisher","first-page":"811","DOI":"10.22037\/ijpr.2015.1686","volume":"14","author":"M Shariatpanahi","year":"2015","unstructured":"Shariatpanahi M, Khodagholi F, Ashabi G, Khasraghi AA, Azimi L, Abdollahi M, Ghahremani MH, Ostad SN, Noorbakhsh F, Sharifzadeh M (2015) Ameliorating of memory impairment and apoptosis in amyloid \u03b2-injected rats via inhibition of nitric oxide synthase: Possible participation of autophagy. Iran J Pharm Res 14:811\u2013824. https:\/\/doi.org\/10.22037\/ijpr.2015.1686","journal-title":"Iran J Pharm Res"},{"key":"737_CR109","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.1073\/pnas.95.11.6460","volume":"95","author":"M Simons","year":"1998","unstructured":"Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K (1998) Cholesterol depletion inhibits the generation of - amyloid in hippocampal neurons. Proc Natl Acad Sci U S A 95:6460\u20136464. https:\/\/doi.org\/10.1073\/pnas.95.11.6460","journal-title":"Proc Natl Acad Sci U S A"},{"key":"737_CR110","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nrn3896","volume":"16","author":"SA Small","year":"2015","unstructured":"Small SA, Petsko GA (2015) Retromer in Alzheimer disease, Parkinson disease and other neurological disorders. Nat Rev Neurosci 16:126\u2013132. https:\/\/doi.org\/10.1038\/nrn3896","journal-title":"Nat Rev Neurosci"},{"key":"737_CR111","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13024-016-0098-z","volume":"11","author":"S S\u00f6llvander","year":"2016","unstructured":"S\u00f6llvander S, Nikitidou E, Brolin R, S\u00f6derberg L, Sehlin D, Lannfelt L, Erlandsson A (2016) Accumulation of amyloid-\u03b2 by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons. Mol Neurodegener 11:38. https:\/\/doi.org\/10.1186\/s13024-016-0098-z","journal-title":"Mol Neurodegener"},{"key":"737_CR112","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.neurobiolaging.2010.09.018","volume":"33","author":"ML Steele","year":"2012","unstructured":"Steele ML, Robinson SR (2012) Reactive astrocytes give neurons less support: implications for Alzheimer\u2019s disease. Neurobiol Aging 33:423. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.09.018","journal-title":"Neurobiol Aging"},{"key":"737_CR113","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1126\/science.1105681","volume":"307","author":"GB Stokin","year":"2005","unstructured":"Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LSB (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease. Science 307:1282\u20131288. https:\/\/doi.org\/10.1126\/science.1105681","journal-title":"Science"},{"key":"737_CR114","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-cellbio-100109-104117","volume":"26","author":"BD Strooper","year":"2010","unstructured":"Strooper BD, Annaert W (2010) Novel research horizons for presenilins and \u03b3-secretases in cell biology and disease. Annu Rev Cell Dev Biol 26:235\u2013260. https:\/\/doi.org\/10.1146\/annurev-cellbio-100109-104117","journal-title":"Annu Rev Cell Dev Biol"},{"key":"737_CR115","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.yexcr.2008.10.013","volume":"315","author":"S Stuffers","year":"2009","unstructured":"Stuffers S, Brech A, Stenmark H (2009) ESCRT proteins in physiology and disease. Exp Cell Res 315:1619\u20131626. https:\/\/doi.org\/10.1016\/j.yexcr.2008.10.013","journal-title":"Exp Cell Res"},{"key":"737_CR116","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuron.2008.10.001","volume":"60","author":"B Sun","year":"2008","unstructured":"Sun B, Zhou Y, Halabisky B, Lo I, Cho S, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer\u2019s disease. Neuron 60:247\u2013257. https:\/\/doi.org\/10.1016\/j.neuron.2008.10.001","journal-title":"Neuron"},{"key":"737_CR117","doi-asserted-by":"publisher","unstructured":"Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. 161:1869\u20131879. https:\/\/doi.org\/10.1016\/s0002-9440(10)64463-x","DOI":"10.1016\/s0002-9440(10)64463-x"},{"key":"737_CR118","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nature01506","volume":"422","author":"N Takasugi","year":"2003","unstructured":"Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) The role of presenilin cofactors in the \u03b3-secretase complex. Nature 422:438\u2013441. https:\/\/doi.org\/10.1038\/nature01506","journal-title":"Nature"},{"key":"737_CR119","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13041-014-0054-1","volume":"7","author":"JHK Tam","year":"2014","unstructured":"Tam JHK, Seah C, Pasternak SH (2014) The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid. Mol Brain 7:54. https:\/\/doi.org\/10.1186\/s13041-014-0054-1","journal-title":"Mol Brain"},{"key":"737_CR120","doi-asserted-by":"publisher","first-page":"e0161445","DOI":"10.1371\/journal.pone.0161445","volume":"11","author":"JHK Tam","year":"2016","unstructured":"Tam JHK, Cobb MR, Seah C, Pasternak SH (2016) Tyrosine binding protein sites regulate the intracellular trafficking and processing of amyloid precursor protein through a novel lysosome-directed pathway. PLoS One 11:e0161445. https:\/\/doi.org\/10.1371\/journal.pone.0161445","journal-title":"PLoS One"},{"key":"737_CR121","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/j.1471-4159.2011.07623.x","volume":"120","author":"J Tan","year":"2012","unstructured":"Tan J, Evin G (2012) Beta-site APP-cleaving enzyme 1 trafficking and Alzheimer\u2019s disease pathogenesis. J Neurochem 120:869\u2013880. https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07623.x","journal-title":"J Neurochem"},{"key":"737_CR122","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s11010-009-0277-0","volume":"335","author":"B Tancini","year":"2009","unstructured":"Tancini B, Magini A, Latterini L, Urbanelli L, Ciccarone V, Elisei F, Emiliani C (2009) Occurrence of an anomalous endocytic compartment in fibroblasts from Sandhoff disease patients. Mol Cell Biochem 335:273\u2013282. https:\/\/doi.org\/10.1007\/s11010-009-0277-0","journal-title":"Mol Cell Biochem"},{"key":"737_CR123","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuron.2017.03.020","volume":"94","author":"P Temkin","year":"2017","unstructured":"Temkin P, Morishita W, Goswami D, Arendt K, Chen L, Malenka R (2017) The retromer supports AMPA receptor trafficking during LTP. Neuron 94:74\u201382. https:\/\/doi.org\/10.1016\/j.neuron.2017.03.020","journal-title":"Neuron"},{"key":"737_CR124","doi-asserted-by":"publisher","first-page":"17071","DOI":"10.1073\/pnas.1315110110","volume":"110","author":"Y Tian","year":"2013","unstructured":"Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P (2013) Adaptor complex AP2\/PICALM, through interaction with LC3, targets Alzheimer\u2019s APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci U S A 110:17071\u201317076. https:\/\/doi.org\/10.1073\/pnas.1315110110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"737_CR125","doi-asserted-by":"publisher","first-page":"a018358","DOI":"10.1101\/cshperspect.a018358","volume":"6","author":"SA Tooze","year":"2014","unstructured":"Tooze SA, Abada A, Elazar Z (2014) Endocytosis and autophagy: exploitation or cooperation? Cold Spring Harb Perspect Biol 6:a018358. https:\/\/doi.org\/10.1101\/cshperspect.a018358","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"737_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.612757","author":"M Tran","year":"2021","unstructured":"Tran M, Reddy PH (2021) Defective autophagy and mitophagy in aging and Alzheimer\u2019s disease. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2020.612757","journal-title":"Front Neurosci"},{"key":"737_CR127","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bbrc.2020.12.113","volume":"543","author":"MN Uddin","year":"2021","unstructured":"Uddin MN, Elahi M, Shimonaka S, Kakuta S, Ishiguro K, Motoi Y, Hattori N (2021) Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochem Biophys Res Commun 543:65\u201371. https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.113","journal-title":"Biochem Biophys Res Commun"},{"key":"737_CR128","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41380-018-0221-3","volume":"24","author":"AN Vagnozzi","year":"2018","unstructured":"Vagnozzi AN, Pratic\u00f2 D (2018) Endosomal sorting and trafficking, the retromer complex and neurodegeneration. Mol Psychiatry 24:857\u2013868. https:\/\/doi.org\/10.1038\/s41380-018-0221-3","journal-title":"Mol Psychiatry"},{"key":"737_CR129","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10545-014-9794-4","volume":"38","author":"MT Vanier","year":"2014","unstructured":"Vanier MT (2014) Complex lipid trafficking in Niemann-Pick disease type C. J Inherit Metab Dis 38:187\u2013199. https:\/\/doi.org\/10.1007\/s10545-014-9794-4","journal-title":"J Inherit Metab Dis"},{"key":"737_CR130","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735\u2013741. https:\/\/doi.org\/10.1126\/science.286.5440.735","journal-title":"Science"},{"key":"737_CR131","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10545-008-1040-5","volume":"32","author":"SU Walkley","year":"2009","unstructured":"Walkley SU (2009) Pathogenic cascades in lysosomal disease\u2014Why so complex? J Inherit Metab Dis 32:181\u2013189. https:\/\/doi.org\/10.1007\/s10545-008-1040-5","journal-title":"J Inherit Metab Dis"},{"key":"737_CR132","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1007\/s00018-012-1201-4","volume":"70","author":"D Wang","year":"2013","unstructured":"Wang D, Chan CC, Cherry S, Hiesinger PR (2013) Membrane trafficking in neuronal maintenance and degeneration. Cell Mol Life Sci 70:2919\u20132934. https:\/\/doi.org\/10.1007\/s00018-012-1201-4","journal-title":"Cell Mol Life Sci"},{"key":"737_CR133","doi-asserted-by":"publisher","first-page":"13969","DOI":"10.1074\/jbc.R800039200","volume":"284","author":"MS Wolfe","year":"2009","unstructured":"Wolfe MS (2009) Intramembrane-cleaving Proteases. J Biol Chem 284:13969\u201313973. https:\/\/doi.org\/10.1074\/jbc.R800039200","journal-title":"J Biol Chem"},{"key":"737_CR134","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1111\/ejn.12169","volume":"37","author":"DM Wolfe","year":"2013","unstructured":"Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA (2013) Autophagy failure in Alzheimer\u2019s disease and the role of defective lysosomal acidification. Eur J Neurosci 37:1949\u20131961. https:\/\/doi.org\/10.1111\/ejn.12169","journal-title":"Eur J Neurosci"},{"key":"737_CR135","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2011.09.036","volume":"147","author":"J Wu","year":"2011","unstructured":"Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF (2011) Arc\/Arg3.1 regulates an endosomal pathway essential for activity-dependent betaamyloid generation. Cell 147:615\u2013628. https:\/\/doi.org\/10.1016\/j.cell.2011.09.036","journal-title":"Cell"},{"key":"737_CR136","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1172\/JCI82409","volume":"126","author":"W Xu","year":"2016","unstructured":"Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Matthew L, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C (2016) Amyloid precursor protein\u2013mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest 126:1815\u20131833. https:\/\/doi.org\/10.1172\/JCI82409","journal-title":"J Clin Invest"},{"issue":"11","key":"737_CR137","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/glia.23191","volume":"65","author":"H Yang","year":"2017","unstructured":"Yang H, Wang Y, Kar S (2017) Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes. Glia 65(11):1728\u20131743. https:\/\/doi.org\/10.1002\/glia.23191","journal-title":"Glia"},{"key":"737_CR138","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1006\/bbrc.2000.4181","volume":"280","author":"SW Yeon","year":"2001","unstructured":"Yeon SW, Jung MW, Ha MJ, Kim SU, Huh K, Savage MJ, Masliah E, Mook-Jung I (2001) Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein. Biochem Biophys Res Commun 280:782\u2013787. https:\/\/doi.org\/10.1006\/bbrc.2000.4181","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"737_CR139","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1515\/revneuro-2014-0076","volume":"26","author":"A Zare-Shahabadi","year":"2014","unstructured":"Zare-Shahabadi A, Masliah E, Johnson GV, Rezaei N (2014) Autophagy in Alzheimer\u2019s disease. Rev Neurosci 26(4):385\u2013395. https:\/\/doi.org\/10.1515\/revneuro-2014-0076","journal-title":"Rev Neurosci"},{"key":"737_CR140","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3233\/JAD-200690","volume":"79","author":"L Zhu","year":"2021","unstructured":"Zhu L, Yuan Q, Zeng Z, Zhou R, Luo R, Zhang J, Tsang CK, Bi W (2021) Rifampicin suppresses amyloid-\u03b2 accumulation through enhancing autophagy in the hippocampus of a lipopolysaccharide-induced mouse model of cognitive decline. J Alzheimers Dis 79:1171\u20131184. https:\/\/doi.org\/10.3233\/JAD-200690","journal-title":"J Alzheimers Dis"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-021-00737-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-021-00737-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-021-00737-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T10:13:47Z","timestamp":1625912027000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-021-00737-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":140,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["737"],"URL":"https:\/\/doi.org\/10.1007\/s11011-021-00737-0","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"21 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest, financial or otherwise.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}