{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:40:40Z","timestamp":1791294040437,"version":"4.1.0"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s11011-021-00776-7","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T11:02:51Z","timestamp":1626346971000},"page":"1481-1499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase"],"prefix":"10.1007","volume":"36","author":[{"given":"V\u00e2nia Machado","family":"Recart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Spohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Sandrielly Pereira","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Pereira","family":"Luduvico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli Moro","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-2000","authenticated-orcid":false,"given":"Roselia Maria","family":"Spanevello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"776_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0165-0327(00)00354-2","volume":"62","author":"M Ackenheil","year":"2001","unstructured":"Ackenheil M (2001) Neurotransmitters and signal transduction processes in bipolar affective disorders: a synopsis. J Affect Disord 62:101\u2013111. https:\/\/doi.org\/10.1016\/s0165-0327(00)00354-2","journal-title":"J Affect Disord"},{"key":"776_CR2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.30773\/pi.2016.12.31","volume":"15","author":"S Akarsu","year":"2018","unstructured":"Akarsu S, Bolu A, Aydemir E, Zincir S, Kurt YG, Zincir S, Erdem M, Uzun O (2018) The relationship between the number of manic episodes and oxidative stress indicators in bipolar disorder. Psych Invest 15:514\u2013519. https:\/\/doi.org\/10.30773\/pi.2016.12.31","journal-title":"Psych Invest"},{"key":"776_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/pcn.12433","volume":"71","author":"F Aldinger","year":"2017","unstructured":"Aldinger F, Schulze TG (2017) Environmental factors, life events, and trauma in the course of bipolar disorder. Psychiatry Clin Neurosci 71:6\u201317. https:\/\/doi.org\/10.1111\/pcn.12433","journal-title":"Psychiatry Clin Neurosci"},{"key":"776_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/08039488.2018.1424238","volume":"72","author":"N Altunsoy","year":"2018","unstructured":"Altunsoy N, Y\u00fcksel RN, Cingi M, K\u0131l\u0131\u00e7arslan A, Aydemir \u00c7 (2018) Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity. Nord J Psychiatry 72:221\u2013225. https:\/\/doi.org\/10.1080\/08039488.2018.1424238","journal-title":"Nord J Psychiatry"},{"key":"776_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jad.2008.04.013","volume":"111","author":"AC Andreazza","year":"2008","unstructured":"Andreazza AC, Kauer-Sant\u2019anna M, Frey BN, Bond DJ, Kapczinski F, Young LT, Yatham LN (2008) Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 111:135\u2013144. https:\/\/doi.org\/10.1016\/j.jad.2008.04.013","journal-title":"J Affect Disord"},{"key":"776_CR6","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.jep.2010.01.008","volume":"128","author":"DMO Arag\u00e3o","year":"2010","unstructured":"Arag\u00e3o DMO, Guarize L, Lanini J, da Costa JC, Garcia RMG, Scio E (2010) Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J Ethnopharmacol 128:629\u2013633. https:\/\/doi.org\/10.1016\/j.jep.2010.01.008","journal-title":"J Ethnopharmacol"},{"key":"776_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.phanu.2016.03.001","volume":"4","author":"P Arunagiri","year":"2016","unstructured":"Arunagiri P, Balamurugan E (2016) Omega-3 fatty acids combined with aripiprazole and lithium modulates activity of mitochondrial enzymes and acetylcholinesterase in methylphenidate-induced animal model of mania. Pharma Nutrition 4:54\u201361. https:\/\/doi.org\/10.1016\/j.phanu.2016.03.001","journal-title":"Pharma Nutrition"},{"key":"776_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.phanu.2013.11.128","volume":"2","author":"P Arunagiri","year":"2014","unstructured":"Arunagiri P, Rajeshwaran K, Shanthakumar J, Balamurugan E (2014a) Supplementation of omega3 fatty acids with aripiprazole and lithium lessens methylphenidate induced manic behavior in Swiss albino mice. Pharma Nutrition 2:26\u201332","journal-title":"Pharma Nutrition"},{"key":"776_CR9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s12011-014-0067-8","volume":"160","author":"P Arunagiri","year":"2014","unstructured":"Arunagiri P, Rajeshwaran K, Shanthakumar J, Tamilselvan T, Balamurugan E (2014b) Combination of omega-3 fatty acids, lithium, and aripiprazole reduces oxidative stress in brain of mice with mania. Biol Trace Elem Res 160:409\u2013417","journal-title":"Biol Trace Elem Res"},{"key":"776_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813455.2020.1851726","volume":"2020","author":"M Asle-Rousta","year":"2020","unstructured":"Asle-Rousta M, Amini R, Aghazadeh S (2020) Carvone suppresses oxidative stress and inflammation in the liver of immobilised rats. Arch Physiol Biochem 2020:1\u20136. https:\/\/doi.org\/10.1080\/13813455.2020.1851726","journal-title":"Arch Physiol Biochem"},{"key":"776_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1590\/1516-4446-2013-1299","volume":"36","author":"O Aydemir","year":"2014","unstructured":"Aydemir O, \u00c7ubuk\u00e7uoglu Z, Erdin S, Tas C, Onur E, Berk M (2014) Oxidative stress markers, cognitive functions, and psyshosocial functioning in bipolar disorder: an empirical cross-sectional study. Rev Bras Psiquiatr 36:293\u2013297","journal-title":"Rev Bras Psiquiatr"},{"key":"776_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bbr.2017.08.014","volume":"335","author":"TB Bassani","year":"2017","unstructured":"Bassani TB, Turnes JM, Moura ELR, Bonato JM, C\u00f3ppola-Segovia V, Zanata SM, Oliveira RMMW, Vital MABF (2017) Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer\u2019s type. Behav Brain Res 335:41\u201354. https:\/\/doi.org\/10.1016\/j.bbr.2017.08.014","journal-title":"Behav Brain Res"},{"key":"776_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1176\/appi.ajp.161.1.3","volume":"161","author":"MS Bauer","year":"2004","unstructured":"Bauer MS, Mitchner L (2004) What is a \u201cmood stabilizer\u201d? An evidence-based response. Am J Psychiatry 161:3\u201318. https:\/\/doi.org\/10.1176\/appi.ajp.161.1.3","journal-title":"Am J Psychiatry"},{"key":"776_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s13167-019-00191-0","volume":"11","author":"Y Beckmann","year":"2019","unstructured":"Beckmann Y, T\u00fcre S, Duman SU (2019) Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients. EPMA J 11:65\u201372. https:\/\/doi.org\/10.1007\/s13167-019-00191-0","journal-title":"EPMA J"},{"key":"776_CR15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bbr.2007.09.012","volume":"187","author":"F Benedetti","year":"2008","unstructured":"Benedetti F, Fresi F, Maccioni P, Smeraldi E (2008) Behavioural sensitization to repeated sleep deprivation in a mice model of mania. Behav Brain Res 187:221\u2013227. https:\/\/doi.org\/10.1016\/j.bbr.2007.09.012","journal-title":"Behav Brain Res"},{"key":"776_CR16","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.biopsych.2008.04.022","volume":"6","author":"M Berk","year":"2008","unstructured":"Berk M, Copolov DL, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI (2008) N-acetyl cysteine for depressive symptoms in bipolar disorder\u2013a double-blind randomized placebo-controlled trial. Biol Psych 6:468\u2013475. https:\/\/doi.org\/10.1016\/j.biopsych.2008.04.022","journal-title":"Biol Psych"},{"key":"776_CR17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jad.2011.06.005","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, Dean O, Cotton SM, Gama CS, Kapczinski F, Fernandes BS, Kolmann K, Jeavons S, Hevitt K, Allwang C, Cobb H, Bush A, Schapkaitz I, Dodd S, Malhi G (2011a) The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial. J Affect Disord 35:389\u2013394. https:\/\/doi.org\/10.1016\/j.jad.2011.06.005","journal-title":"J Affect Disord"},{"key":"776_CR18","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, Y\u00fccel M, Gama CS, Dodd S, Dean B, Magalh\u00e3es PVS, Amminger P, Mcgorry P, Malhi GS (2011b) Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 35:804\u2013817. https:\/\/doi.org\/10.1016\/j.neubiorev.2010.10.001","journal-title":"Neurosci Biobehav Rev"},{"key":"776_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40345-017-0104-6","volume":"5","author":"DKE Beyer","year":"2017","unstructured":"Beyer DKE, Freund N (2017) Animal models for bipolar disorder: from bedside to the cage. Int J Bipolar Disord 5:1\u201326. https:\/\/doi.org\/10.1186\/s40345-017-0104-6","journal-title":"Int J Bipolar Disord"},{"key":"776_CR20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/1028415X.2017.1287833","volume":"21","author":"EL Boespflug","year":"2018","unstructured":"Boespflug EL, Eliassen JC, Dudley JA, Shidler MD, Kalt W, Summer SS, Stein AL, Stover AN, Krikorian R (2018) Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutr Neurosci 21:297\u2013305. https:\/\/doi.org\/10.1080\/1028415X.2017.1287833","journal-title":"Nutr Neurosci"},{"key":"776_CR21","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.mehy.2013.02.001","volume":"80","author":"E Brietzke","year":"2013","unstructured":"Brietzke E, Mansur RB, Zugman A, Carvalho AF, Mac\u00eado DS, Cha DS, Ab\u00edlio VC, McIntyre RS (2013) Is there a role for curcumin in the treatment of bipolar disorder? Med Hypotheses 80:606\u2013612. https:\/\/doi.org\/10.1016\/j.mehy.2013.02.001","journal-title":"Med Hypotheses"},{"key":"776_CR22","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1007\/s12035-016-9933-z","volume":"54","author":"K Cancelier","year":"2017","unstructured":"Cancelier K, Gomes LM, Carvalho-Silva M, Teixeira LJ, Rebelo J, Mota IT, Arent CO, Mariot E, Kist LW, Bogo MR, Quevedo J, Scaini G (2017) Omega-3 fatty acids and mood stabilizers alter behavioural and energy metabolism parameters in animals subjected to an animal model of mania induced by Fenproporex. Mol Neurobiol 54:3935\u20133947. https:\/\/doi.org\/10.1007\/s12035-016-9933-z","journal-title":"Mol Neurobiol"},{"key":"776_CR23","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1056\/NEJMra1906193","volume":"383","author":"F Carvalho","year":"2020","unstructured":"Carvalho F, Firth J, Vieta E (2020) Bipolar disorder. N Engl J Med 383:58\u201366. https:\/\/doi.org\/10.1056\/NEJMra1906193","journal-title":"N Engl J Med"},{"key":"776_CR24","doi-asserted-by":"publisher","first-page":"134566","DOI":"10.1016\/j.neulet.2019.134566","volume":"714","author":"VC Chaves","year":"2020","unstructured":"Chaves VC, Soares MSP, Spohr L, Teixeira F, Vieira A, Constantino LS, Pizzol FD, Lencina CL, Spanevello RM, Freitas MP, Sim\u00f5es CMO, Reginatto FH, Stefanello FM (2020) Blackberry extract improves behavioral and neurochemical dysfunctions in a ketamine-induced rat model of mania. Neurosci Lett 714:134566. https:\/\/doi.org\/10.1016\/j.neulet.2019.134566","journal-title":"Neurosci Lett"},{"key":"776_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.phymed.2018.09.182","volume":"50","author":"D Chen","year":"2018","unstructured":"Chen D, Wang Y, Fen Y, Gao G, Zhao Y (2018) Natural products for the prevention and treatment of kidney disease. Phytomed 50:50\u201360. https:\/\/doi.org\/10.1016\/j.phymed.2018.09.182","journal-title":"Phytomed"},{"key":"776_CR26","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.4088\/JCP.13m0841","volume":"74","author":"KN Chengappa","year":"2013","unstructured":"Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R (2013) Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry 74:1076\u20131083. https:\/\/doi.org\/10.4088\/JCP.13m0841","journal-title":"J Clin Psychiatry"},{"key":"776_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1034\/j.1399-5618.2000.020107.x","volume":"2","author":"KN Chengappa","year":"2000","unstructured":"Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A, Pollock J, Luther J, Buttenfield J, Vertafaile S, Kupfer D (2000) Inositol as an add-on treatment for bipolar depression. Bipolar Disord 2:47\u201355. https:\/\/doi.org\/10.1034\/j.1399-5618.2000.020107.x","journal-title":"Bipolar Disord"},{"key":"776_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1124\/pr.111.005512","volume":"65","author":"CT Chiu","year":"2013","unstructured":"Chiu CT, Wang Z, Hunsberger JG, Chuang DM (2013) Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacol Rev 65:105\u2013142. https:\/\/doi.org\/10.1124\/pr.111.005512","journal-title":"Pharmacol Rev"},{"key":"776_CR29","doi-asserted-by":"publisher","first-page":"305","DOI":"10.4155\/ppa.15.14","volume":"4","author":"S Choubey","year":"2015","unstructured":"Choubey S, Varughese LR, Kumar V, Beniwal V (2015) Medicinal importance of gallic acid and its ester derivatives: a patent review. Pharm Pat Anal 4:305\u2013315. https:\/\/doi.org\/10.4155\/ppa.15.14","journal-title":"Pharm Pat Anal"},{"key":"776_CR30","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jtemb.2016.09.012","volume":"39","author":"MI Chowdhury","year":"2017","unstructured":"Chowdhury MI, Hasan M, Islam MS, Sarwar MS, Amin MN, Uddin SMN, Rahaman MZ, Banik S, Hussain MS, Yokota K, Hasnat A (2017) Elevated serum MDA and depleted nonenzymatic antioxidants, macrominerals and traceelements are associated with bipolar disorder. J Trace Elem Med Biol 39:162\u2013168. https:\/\/doi.org\/10.1016\/j.jtemb.2016.09.012","journal-title":"J Trace Elem Med Biol"},{"key":"776_CR31","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ejcn.2008.81","volume":"63","author":"EH Clayton","year":"2009","unstructured":"Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML (2009) Hazell PL (2009) Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr 63:1037\u20131040. https:\/\/doi.org\/10.1038\/ejcn.2008.81","journal-title":"Eur J Clin Nutr"},{"key":"776_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/14737175.2018.1407242","volume":"18","author":"GD Colpo","year":"2018","unstructured":"Colpo GD, Leboyer M, Dantzer R, Trivedi MH, Teixeira AL (2018) Immune-based strategies for mood disorders: facts and challenges. Expert Rev Neurother 18:139\u2013152. https:\/\/doi.org\/10.1080\/14737175.2018.1407242","journal-title":"Expert Rev Neurother"},{"key":"776_CR33","doi-asserted-by":"publisher","first-page":"2986796","DOI":"10.1155\/2016\/2986796","volume":"2016","author":"LG Costa","year":"2016","unstructured":"Costa LG, Garrick JM, Roqu\u00e8 PJ, Pellacani C (2016) Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev 2016:2986796. https:\/\/doi.org\/10.1155\/2016\/2986796","journal-title":"Oxid Med Cell Longev"},{"key":"776_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mce.2017.05.035","volume":"453","author":"X Cui","year":"2017","unstructured":"Cui X, Gooch H, Petty A, McGrath JJ, Eyles D (2017) Vitamin D and the brain: genomic and non-genomic actions. Mol Cell Endocrinol 453:131\u2013143. https:\/\/doi.org\/10.1016\/j.mce.2017.05.035","journal-title":"Mol Cell Endocrinol"},{"key":"776_CR35","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","volume":"61","author":"SR Dager","year":"2004","unstructured":"Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK, Dunner DL, Renshaw PF (2004) Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 61:450\u2013458. https:\/\/doi.org\/10.1001\/archpsyc.61.5.450","journal-title":"Arch Gen Psychiatry"},{"key":"776_CR36","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/j.1440-1819.2012.02392.x","volume":"66","author":"OM Dean","year":"2012","unstructured":"Dean OM, Bush AI, Copolov DL, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2012) Effects of N-acetyl cysteine on cognitive function in bipolar disorder. Psychiatry Clin Neurosc 66:514\u2013517. https:\/\/doi.org\/10.1111\/j.1440-1819.2012.02392.x","journal-title":"Psychiatry Clin Neurosc"},{"key":"776_CR37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.brainresbull.2016.10.008","volume":"127","author":"G Debom","year":"2016","unstructured":"Debom G, Gazal M, Soares MSP, Couto CAT, Mattos B, Lencina C, Kaster MP, Ghisleni GC, Tavares R, Braganhol E, Chaves VC, Reginatto FH, Stefanello F, Spanevello RM (2016) Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine. Brain Res Bull 127:260\u2013269. https:\/\/doi.org\/10.1016\/j.brainresbull.2016.10.008","journal-title":"Brain Res Bull"},{"key":"776_CR38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neubiorev.2015.04.015","volume":"55","author":"SJ Deepmala","year":"2015","unstructured":"Deepmala SJ, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R (2015) Clinical trials of N-acetylcysteine in Psychiatry and Neurology: a systematic review. Neurosci Biobehav Rev 55:294\u2013321. https:\/\/doi.org\/10.1016\/j.neubiorev.2015.04.015","journal-title":"Neurosci Biobehav Rev"},{"key":"776_CR39","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.3390\/ijms20215310","volume":"20","author":"R Dutta","year":"2019","unstructured":"Dutta R, Khalil R, Green R, Mohapatra SS, Mohapatra S (2019) Withania Somnifera (Ashwagandha) and Withaferin A: potential in integrative oncology. Int J Mol Sci 20:5310. https:\/\/doi.org\/10.3390\/ijms20215310","journal-title":"Int J Mol Sci"},{"key":"776_CR40","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/0278-5846(95)00123-d","volume":"19","author":"RS El-Mallakh","year":"1995","unstructured":"El-Mallakh RS, Harrison LT, Li R, Changaris DG, Levy RS (1995) An animal model for mania: preliminary results. Prog Neuropsychopharmacol Biol Psychiatry 19:955\u2013962. https:\/\/doi.org\/10.1016\/0278-5846(95)00123-d","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"776_CR41","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/sj.mp.4002135","volume":"14","author":"SR Engel","year":"2009","unstructured":"Engel SR, Creson TK, Hao Y, Shen Y, Maeng S, Nekrasova T, Landreth GE, Manji HK, Chen G (2009) The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement. Mol Psychiatry 14:448\u2013461. https:\/\/doi.org\/10.1038\/sj.mp.4002135","journal-title":"Mol Psychiatry"},{"key":"776_CR42","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/0896-6273(90)90090-3","volume":"5","author":"P Ernfors","year":"1990","unstructured":"Ernfors P, Wetmore C, Olson L, Persson H (1990) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511\u2013526. https:\/\/doi.org\/10.1016\/0896-6273(90)90090-3","journal-title":"Neuron"},{"key":"776_CR43","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1399-5618.2006.00303.x","volume":"8","author":"E Evins","year":"2006","unstructured":"Evins E, Demopulos C, Yovel I, Culhane M, Ogutha J, Grandin LD, Nierenberg AA, Sachs GS (2006) Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disord 8:168\u2013174. https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00303.x","journal-title":"Bipolar Disord"},{"key":"776_CR44","doi-asserted-by":"publisher","first-page":"e3154","DOI":"10.1002\/dmrr.3154","volume":"35","author":"G Formoso","year":"2019","unstructured":"Formoso G, Baldassarre MPA, Ginestra F, Carlucci MA, Bucci I, Consoli A (2019) Inositol and antioxidant supplementation: safety and efficacy in pregnancy. Diabetes Metab Res Ver 35:e3154. https:\/\/doi.org\/10.1002\/dmrr.3154","journal-title":"Diabetes Metab Res Ver"},{"key":"776_CR45","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1039\/c8fo01997e","volume":"10","author":"CG Fraga","year":"2019","unstructured":"Fraga CG, Croft KD, Kennedy DO, Tom\u00e1s-Barber\u00e1n FA (2019) The effects of polyphenols and other bioactives on human health. Food Funct 10:514\u2013528. https:\/\/doi.org\/10.1039\/c8fo01997e","journal-title":"Food Funct"},{"key":"776_CR46","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1192\/bjp.188.1.46","volume":"188","author":"S Frangou","year":"2006","unstructured":"Frangou S, Lewis M, McCrone P (2006) Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study. Br J Psychiatry 188:46\u201350. https:\/\/doi.org\/10.1192\/bjp.188.1.46","journal-title":"Br J Psychiatry"},{"key":"776_CR47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-1-4939-9554-7_4","volume":"2011","author":"N Freund","year":"2019","unstructured":"Freund N, Juckel G (2019) Bipolar disorder: its Etiology and how to model in rodents. Methods Mol Biol 2011:61\u201377. https:\/\/doi.org\/10.1007\/978-1-4939-9554-7_4","journal-title":"Methods Mol Biol"},{"key":"776_CR48","first-page":"326","volume":"31","author":"BN Frey","year":"2006","unstructured":"Frey BN, Valvassori SS, Reus GZ, Martins MR, Petronilho FC, Bardini K, Dal-Pizzol F, Kapczinski F, Quevedo J (2006) Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychiatry Neurosci 31:326\u2013332","journal-title":"J Psychiatry Neurosci"},{"key":"776_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pbb.2018.12.006","volume":"177","author":"GR Fries","year":"2019","unstructured":"Fries GR, Walss-bass C, Bauer ME, Teixeira AL (2019) Revisiting inflammation in bipolar disorder. Pharmacol Biochem Behav 177:12\u201319. https:\/\/doi.org\/10.1016\/j.pbb.2018.12.006","journal-title":"Pharmacol Biochem Behav"},{"key":"776_CR50","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s11064-015-1610-5","volume":"40","author":"M Gazal","year":"2015","unstructured":"Gazal M, Kaufmann FN, Acosta BA, Oliveira PS, Valente MR, Ortmann CF, Sturbelle R, Lencina CL, Stefanello FM, Kaster MP, Reginatto FH, Ghisleni G (2015) Preventive effect of Cecropia pachystachya against ketamine-induced manic behavior and oxidative stress in rats. Neurochem Res 40:1421\u20131430. https:\/\/doi.org\/10.1007\/s11064-015-1610-5","journal-title":"Neurochem Res"},{"key":"776_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2014.07.007","volume":"108","author":"M Gazal","year":"2014","unstructured":"Gazal M, Ortmann CF, Martins FA, Streck EL, Quevedo J, de Campos AM, Stefanello FM, Kaster MP, Ghisleni G, Reginatto FH, Lencina CL (2014a) Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress. Brain Res Bull 108:10\u201317. https:\/\/doi.org\/10.1016\/j.brainresbull.2014.07.007","journal-title":"Brain Res Bull"},{"key":"776_CR52","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejphar.2013.12.028","volume":"5","author":"M Gazal","year":"2014","unstructured":"Gazal M, Valente MR, Acosta BA, Kaufmann FN, Braganhol E, Lencina CL, Stefanello FM, Ghisleni G, Kaster MP (2014b) Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats. Eur J Pharmacol 5:132\u2013139. https:\/\/doi.org\/10.1016\/j.ejphar.2013.12.028","journal-title":"Eur J Pharmacol"},{"key":"776_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2045-9912-3-11","volume":"11","author":"A Ghanizadeh","year":"2013","unstructured":"Ghanizadeh A, Berk M (2013) Molecular hydrogen: an overview of its neurobiological effects and therapeutical potential for bipolar disorder and schizophrenia. Med Gas Res 11:1\u20136. https:\/\/doi.org\/10.1186\/2045-9912-3-11","journal-title":"Med Gas Res"},{"key":"776_CR54","doi-asserted-by":"publisher","unstructured":"Ghedim FV, de Fraga DB, Deroza PF, Oliveira MB, Valvassori SS, Steckert AV, Budni J, Dal-Pizzol F, Quevedo J, Zugno AI (2012) Evaluation of behavioral and neurochemical changes induced by ketamine in rats: implications as an animal model of mania. J Psychiatr Res 46(1569):1575. https:\/\/doi.org\/10.1016\/j.jpsychires.2012.08.010","DOI":"10.1016\/j.jpsychires.2012.08.010"},{"key":"776_CR55","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/379606a0","volume":"379","author":"B Giros","year":"1996","unstructured":"Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606\u2013612. https:\/\/doi.org\/10.1038\/379606a0","journal-title":"Nature"},{"key":"776_CR56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.physbeh.2011.10.029","volume":"106","author":"I Grande","year":"2012","unstructured":"Grande I, Magalh\u00e3es PV, Vieta E, Kapczinski F (2012) Mediators of allostasis and systemic toxicity in bipolar disorder. Physiol Behav 106:46\u201350. https:\/\/doi.org\/10.1016\/j.physbeh.2011.10.029","journal-title":"Physiol Behav"},{"key":"776_CR57","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nature12630","volume":"503","author":"K Han","year":"2013","unstructured":"Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY (2013) SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetics properties. Nature 503:72\u201377. https:\/\/doi.org\/10.1038\/nature12630","journal-title":"Nature"},{"key":"776_CR58","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.mp.4001618","volume":"10","author":"AJ Harwood","year":"2005","unstructured":"Harwood AJ (2005) Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. Mol Psychiatry 10:117\u2013126. https:\/\/doi.org\/10.1038\/sj.mp.4001618","journal-title":"Mol Psychiatry"},{"key":"776_CR59","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/1871527317666180412153612","volume":"17","author":"M Healy-Stoffel","year":"2018","unstructured":"Healy-Stoffel M, Levant B (2018) N-3 (Omega-3) Fatty acids: effects on brain dopamine systems and potential role in the Etiology and treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 17:216\u2013232. https:\/\/doi.org\/10.2174\/1871527317666180412153612","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"776_CR60","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jad.2020.12.151","volume":"282","author":"C Humpstom","year":"2021","unstructured":"Humpstom C, Bebbington P, Marwaha S (2021) Bipolar disorder: prevalence, help-seeking and use of mental health care in England. Findings from the 2014 adult psychiatric morbidity survey. J Affect Disord 282:426\u2013433. https:\/\/doi.org\/10.1016\/j.jad.2020.12.151","journal-title":"J Affect Disord"},{"key":"776_CR61","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/bdi.12980","volume":"23","author":"S Jim\u00e9nez-Fern\u00e1ndez","year":"2021","unstructured":"Jim\u00e9nez-Fern\u00e1ndez S, Gurpegui M, Garrote-Rojas D, Guti\u00e9rrez-Rojas L, Carretero MD, Correll CU (2021) Oxidative stress parameters and antioxidants in patients with bipolar disorder: results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls. Bipolar Disord 23:117\u2013129. https:\/\/doi.org\/10.1111\/bdi.12980","journal-title":"Bipolar Disord"},{"key":"776_CR62","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1152\/ajpcell.00283.2008","volume":"295","author":"D Jones","year":"2008","unstructured":"Jones D (2008) Radical free biology of oxidative stress. Am J Physiol Cell Physiol 295:849\u2013868. https:\/\/doi.org\/10.1152\/ajpcell.00283.2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"776_CR63","doi-asserted-by":"publisher","first-page":"225","DOI":"10.22038\/ijbms.2019.32806.7897","volume":"22","author":"N Kahkeshani","year":"2019","unstructured":"Kahkeshani N, Farzaei F, Fotouhi M, Alavi SS, Bahramsoltani R, Naseri R, Momtaz S, Abbasabadi Z, Rahimi R, Farzaei MH, Bishayee A (2019) Pharmacologial effects of gallic acid in health and disease: a mechanistic review. Iran J Basic Med Sci 22:225\u2013237. https:\/\/doi.org\/10.22038\/ijbms.2019.32806.7897","journal-title":"Iran J Basic Med Sci"},{"key":"776_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2017.01.007","volume":"171","author":"LK Kanazawa","year":"2017","unstructured":"Kanazawa LK, Vecchia DD, Wendler EM, Hocayen PA, Beir\u00e3o PS Jr, de M\u00e9lo ML, Dos Reis L\u00edvero FA, Corso CR, Stipp MC, Acco A, Andreatini R (2017) Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress. Life Sci 171:1\u20138. https:\/\/doi.org\/10.1016\/j.lfs.2017.01.007","journal-title":"Life Sci"},{"key":"776_CR65","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.freeradbiomed.2016.07.027","volume":"99","author":"LKS Kanazawa","year":"2016","unstructured":"Kanazawa LKS, Vecchia DD, Wendler EM, Hocayen PAS, Dos Reis L\u00edvero FA, Stipp MC, Barcaro IMR, Acco A, Andreatini R (2016) Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice. Free Radic Biol Med 99:79\u201386. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.07.027","journal-title":"Free Radic Biol Med"},{"key":"776_CR66","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/bdi.12867","volume":"22","author":"A Karanti","year":"2020","unstructured":"Karanti A, Kardell M, Joas C, Runeson B, Palsson E (2020) Characteristics of bipolar I and II disorder: a study of 8766 individuals. Bipolar Disord 22:392\u2013400. https:\/\/doi.org\/10.1111\/bdi.12867","journal-title":"Bipolar Disord"},{"key":"776_CR67","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1017\/neu.2014.8","volume":"26","author":"S Kasper","year":"2014","unstructured":"Kasper S (2014) Treatment-resistant depression: a challenge for future research. Acta Neuropsychiatr 26:131\u2013133. https:\/\/doi.org\/10.1017\/neu.2014.8","journal-title":"Acta Neuropsychiatr"},{"key":"776_CR68","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3892\/mmr.2011.732","volume":"5","author":"R Khairova","year":"2012","unstructured":"Khairova R, Pawar R, Salvadore G, Juruena MF, Sousa RT, De Soeiro-De-Souza MG, Salvador M, Zarate CA, Gattaz WF, Machado-Vieira R (2012) Effects of lithium on oxidative stress parameters in healthy subjects. Mol Med Rep 5:680\u2013682. https:\/\/doi.org\/10.3892\/mmr.2011.732","journal-title":"Mol Med Rep"},{"key":"776_CR69","doi-asserted-by":"publisher","first-page":"18144","DOI":"10.1073\/pnas.1108416108","volume":"108","author":"G Kirshenbaum","year":"2011","unstructured":"Kirshenbaum G, Clapcote S, Duffy S, Burgess C, Petersen J, Jarowek K, Yucel Y, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+, K+-ATPase \u03b13 sodium pump. Proc Natl Acad Sci 108:18144\u201318149. https:\/\/doi.org\/10.1073\/pnas.1108416108","journal-title":"Proc Natl Acad Sci"},{"issue":"16","key":"776_CR70","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/molecules24162930","volume":"24","author":"RR Kotha","year":"2019","unstructured":"Kotha RR, Luthria DL (2019) Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules 24(16):2930. https:\/\/doi.org\/10.3390\/molecules24162930","journal-title":"Molecules"},{"key":"776_CR71","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1124\/pr.117.014092","volume":"70","author":"S Lay\u00e9","year":"2018","unstructured":"Lay\u00e9 S, Nadjar A, Joffre C, Bazinet RP (2018) Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology. Pharmacol Rev 70:12\u201338. https:\/\/doi.org\/10.1124\/pr.117.014092","journal-title":"Pharmacol Rev"},{"key":"776_CR72","first-page":"490","volume":"60","author":"R Lien","year":"2008","unstructured":"Lien R, Flaisher-Grinberg S, Cleary C, Hejny M, Einat H (2008) Behavioral effects of Bcl-2 deficiency: implications for affective disorders. Pharmacol Rep 60:490\u2013498","journal-title":"Pharmacol Rep"},{"key":"776_CR73","doi-asserted-by":"publisher","first-page":"3479S","DOI":"10.1093\/jn\/134.12.3479S","volume":"134","author":"R Liu","year":"2004","unstructured":"Liu R (2004) Potential synergy of phytochemical in cancer prevention: mechanism of action. J Nutr 134:3479S-3485S. https:\/\/doi.org\/10.1093\/jn\/134.12.3479S","journal-title":"J Nutr"},{"key":"776_CR74","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1399-5618.2012.01046.x","volume":"14","author":"DS Mac\u00eado","year":"2012","unstructured":"Mac\u00eado DS, Medeiros CD, Cordeiro RC, Sousa FC, Santos JV, Morais TA, Hyphantis TN, McIntyre RS, Quevedo J, Carvalho AF (2012) Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine. Bipolar Disord 14:707\u2013718. https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01046.x","journal-title":"Bipolar Disord"},{"key":"776_CR75","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1590\/S1516-44462011000400011","volume":"33","author":"PV Magalh\u00e3es","year":"2011","unstructured":"Magalh\u00e3es PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2011a) N-acetylcysteine for major depressive episodes in bipolar disorder. Rev Bras Psiquiatr 33:374\u2013378. https:\/\/doi.org\/10.1590\/S1516-44462011000400011","journal-title":"Rev Bras Psiquiatr"},{"key":"776_CR76","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jad.2010.08.001","volume":"129","author":"PV Magalh\u00e3es","year":"2011","unstructured":"Magalh\u00e3es PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2011b) N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial. J Affect Disord 129:317\u2013320. https:\/\/doi.org\/10.1016\/j.jad.2010.08.001","journal-title":"J Affect Disord"},{"key":"776_CR77","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1177\/0004867413481631","volume":"47","author":"PV Magalh\u00e3es","year":"2013","unstructured":"Magalh\u00e3es PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2013) A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania. Aust N Z J Psychiatry 47:564\u2013568. https:\/\/doi.org\/10.1177\/0004867413481631","journal-title":"Aust N Z J Psychiatry"},{"key":"776_CR78","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jpsychires.2016.05.014","volume":"80","author":"R Mansur","year":"2016","unstructured":"Mansur R, Ri L, Santos C, Asevedo E, Cunha G, Noto M, Pedrini M, Zeni-Graiff M, Gouvea ES, Cordeiro Q, Reininghaus E, McIntyre R, Brietzke E (2016) Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: a preliminary report. J Psychiatr Res 80:38\u201344. https:\/\/doi.org\/10.1016\/j.jpsychires.2016.05.014","journal-title":"J Psychiatr Res"},{"key":"776_CR79","doi-asserted-by":"publisher","first-page":"9377","DOI":"10.1073\/pnas.0503584102","volume":"102","author":"CA Mcclung","year":"2005","unstructured":"Mcclung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Nat Acad Sci U S A 102:9377\u20139381. https:\/\/doi.org\/10.1073\/pnas.0503584102","journal-title":"Proc Nat Acad Sci U S A"},{"key":"776_CR80","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","volume":"396","author":"R MCintyre","year":"2020","unstructured":"MCintyre R, Berk M, Brietze E, Glodstein B, L\u00f3pez-Jaramillo C, Kessin L, Malhi G, Nierenberg A, Rosenblat J, Majjed A, Vieta E, Vinberg M, Young A, Mansur R (2020) Bipolar disorders. Lancet 396:1841\u20131856. https:\/\/doi.org\/10.1016\/S0140-6736(20)31544-0","journal-title":"Lancet"},{"key":"776_CR81","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","volume":"68","author":"KR Merikangas","year":"2011","unstructured":"Merikangas KR, Jin R, He J, Kessler R, Lee S, Sampson N, Viana MC, Medina-Mora ME, Ono Y, Villa J, Sagar R, Wells JE, Zarkov Z (2011) Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry 68:241\u2013251. https:\/\/doi.org\/10.1001\/archgenpsychiatry.2011.12","journal-title":"Arch Gen Psychiatry"},{"key":"776_CR82","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s00213-003-1440-z","volume":"168","author":"N Michael","year":"2003","unstructured":"Michael N, Erfurth A, Ohrmann P, Gossling M, Arolt V, Heindel W, Pfleiderer B (2003) Acute mania is accompanied by elevated glutamate\/glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacol 168:344\u2013346. https:\/\/doi.org\/10.1007\/s00213-003-1440-z","journal-title":"Psychopharmacol"},{"key":"776_CR83","doi-asserted-by":"publisher","first-page":"18","DOI":"10.4306\/pi.2016.13.1.18","volume":"13","author":"A Muneer","year":"2016","unstructured":"Muneer A (2016) Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig 13:18\u201333. https:\/\/doi.org\/10.4306\/pi.2016.13.1.18","journal-title":"Psychiatry Investig"},{"key":"776_CR84","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/1028415X.2015.1103461","volume":"20","author":"S Nabavi","year":"2017","unstructured":"Nabavi S, Daglia M, Braidy N, Nabavi S (2017) Natural products, micronutrientes, and nutraceuticals for the treatment of depression: a short review. Nut Neurosc 20:180\u2013194. https:\/\/doi.org\/10.1080\/1028415X.2015.1103461","journal-title":"Nut Neurosc"},{"key":"776_CR85","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn.2647","volume":"13","author":"EJ Nestler","year":"2010","unstructured":"Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161\u20131169. https:\/\/doi.org\/10.1038\/nn.2647","journal-title":"Nat Neurosci"},{"key":"776_CR86","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neulet.2016.03.013","volume":"619","author":"FP Nogoceke","year":"2016","unstructured":"Nogoceke FP, Barcaro IM, de Sousa DP, Andreatini R (2016) Antimanic-like effects of (R)-(-)-carvone and (S)-(+)-carvone in mice. Neurosci Lett 619:43\u201348. https:\/\/doi.org\/10.1016\/j.neulet.2016.03.013","journal-title":"Neurosci Lett"},{"key":"776_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40345-014-0017-6","volume":"31","author":"W Nolen","year":"2015","unstructured":"Nolen W (2015) More robust evidence for the efficacy of lithium in the long therm treatment of bipolar disorder: should lithium (again) be recommended as the single preferred first-line treatment. Int J Bipolar Disord 31:1. https:\/\/doi.org\/10.1186\/s40345-014-0017-6","journal-title":"Int J Bipolar Disord"},{"key":"776_CR88","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ejphar.2014.06.042","volume":"740","author":"R Oruch","year":"2014","unstructured":"Oruch R, Elderbi M, Khattab H, Pryme IF, Lund A (2014) Lithium: a review of pharmacology, clinical uses, and toxicity. Eur J Pharmacol 740:464\u2013473. https:\/\/doi.org\/10.1016\/j.ejphar.2014.06.042","journal-title":"Eur J Pharmacol"},{"key":"776_CR89","doi-asserted-by":"publisher","first-page":"726","DOI":"10.4088\/jcp.v66n0608","volume":"66","author":"Y Osher","year":"2005","unstructured":"Osher Y, Bersudsky Y, Belmaker RH (2005) Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study. J Clin Psychiatry 66:726\u2013729. https:\/\/doi.org\/10.4088\/jcp.v66n0608","journal-title":"J Clin Psychiatry"},{"key":"776_CR90","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/301294","volume":"2014","author":"NR Pacheco","year":"2014","unstructured":"Pacheco NR, Pinto NCC, da Silva JM, Mendes RF, da Costa JC, Arag\u00e3o DMO, Casta\u00f1on MCMN, Scio E (2014) Cecropia pachystachya: a species with expressive in vivo topical anti-inflammatory and in vitro antioxidant effects. Biomed Res Int 2014:301294. https:\/\/doi.org\/10.1155\/2014\/301294","journal-title":"Biomed Res Int"},{"issue":"165\u2013183","key":"776_CR91","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/ddr.21587","volume":"81","author":"P Patil","year":"2020","unstructured":"Patil P, Thakur A, Sharma A, Flora S (2020) Natural products and their derivatives as multifunctional ligands against Alzheimer\u00b4s disease. Drug Develop Res 81(165\u2013183):2. https:\/\/doi.org\/10.1002\/ddr.21587","journal-title":"Drug Develop Res"},{"key":"776_CR92","first-page":"483","volume":"85","author":"AL Price","year":"2012","unstructured":"Price AL, Marzani-Nissen GR (2012) Bipolar disorders: a review. Am Fam Physician 85:483\u2013493","journal-title":"Am Fam Physician"},{"key":"776_CR93","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.jpsychires.2011.06.018","volume":"45","author":"F Qin","year":"2011","unstructured":"Qin F, Wu XA, Tang Y, Huang Q, Zhang ZJ, Yuan JH (2011) Meta-analysis of randomized controlled trials to assess the effectiveness and safety of free and easy wanderer plus, a polyherbal preparation for depressive disorders. J Psychiatr Res 45:1518\u20131524. https:\/\/doi.org\/10.1016\/j.jpsychires.2011.06.018","journal-title":"J Psychiatr Res"},{"key":"776_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jdn.10086","volume":"00","author":"VM Recart","year":"2021","unstructured":"Recart VM, Spohr L, Soares MSP, de Mattos BS, Bona NP, Pedra NS, Teixeira FC, Gamaro GD, Stefanello F, Spanevello R (2021) Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic-like behavior: comparison with lithium effects. Int J Dev Neurosci 00:1\u201312. https:\/\/doi.org\/10.1002\/jdn.10086","journal-title":"Int J Dev Neurosci"},{"key":"776_CR95","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1177\/2045125318769235","volume":"8","author":"TA Rowland","year":"2018","unstructured":"Rowland TA, Marwaha S (2018) Epidemiology and risk factors for bipolar disorder. Ther Adv Psychopharmacol 8:251\u2013269. https:\/\/doi.org\/10.1177\/2045125318769235","journal-title":"Ther Adv Psychopharmacol"},{"key":"776_CR96","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.1073\/pnas.0609625104","volume":"104","author":"K Roybal","year":"2007","unstructured":"Roybal K, Theobold D, Graham A, Dinieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, Mcclung CA (2007) Mania-like behavior induced by disruption of CLOCK. Proc Nat Acad Sci 104:6406\u20136411. https:\/\/doi.org\/10.1073\/pnas.0609625104","journal-title":"Proc Nat Acad Sci"},{"key":"776_CR97","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fnmol.2018.00349","volume":"11","author":"JK Rybakowski","year":"2018","unstructured":"Rybakowski JK (2018) Challenging the negative perception of lithium and optimizing its long-term administration. Front Mol Neurosci 11:349. https:\/\/doi.org\/10.3389\/fnmol.2018.00349","journal-title":"Front Mol Neurosci"},{"key":"776_CR98","doi-asserted-by":"publisher","unstructured":"Sairazi N, Sirajudeen K (2020) Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases. Evid Based Complement Altern Med 6565396. https:\/\/doi.org\/10.1155\/2020\/6565396","DOI":"10.1155\/2020\/6565396"},{"key":"776_CR99","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","volume":"1830","author":"Y Samuni","year":"2013","unstructured":"Samuni Y, Goldstein S, Dean OM, Berk M (2013) The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 1830:4117\u20134129. https:\/\/doi.org\/10.1016\/j.bbagen.2013.04.016","journal-title":"Biochim Biophys Acta"},{"key":"776_CR100","doi-asserted-by":"publisher","first-page":"175","DOI":"10.12968\/hmed.2016.77.3.175","volume":"77","author":"KE Saunders","year":"2016","unstructured":"Saunders KE, Geddes JR (2016) The management of bipolar disorder. Br J Hosp Med 77:175\u2013179. https:\/\/doi.org\/10.12968\/hmed.2016.77.3.175","journal-title":"Br J Hosp Med"},{"key":"776_CR101","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.febslet.2015.03.012","volume":"589","author":"S Schneider","year":"2015","unstructured":"Schneider S (2015) Inositol transport proteins. FEBS Lett 589:1049\u20131058. https:\/\/doi.org\/10.1016\/j.febslet.2015.03.012","journal-title":"FEBS Lett"},{"key":"776_CR102","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","volume":"9","author":"F Shahidi","year":"2018","unstructured":"Shahidi F, Ambigaipalan P (2018) Omega-3 Polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol 9:345\u2013381. https:\/\/doi.org\/10.1146\/annurev-food-111317-095850","journal-title":"Annu Rev Food Sci Technol"},{"key":"776_CR103","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/mp.2008.20","volume":"13","author":"G Shaltiel","year":"2008","unstructured":"Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T, Rogawski M, Gasior M, Luckenbaugh D, Chen G, Manji HK (2008) Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Mol Psychiatry 13:858\u2013872. https:\/\/doi.org\/10.1038\/mp.2008.20","journal-title":"Mol Psychiatry"},{"key":"776_CR104","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pnpbp.2015.11.001","volume":"66","author":"AN Sharma","year":"2016","unstructured":"Sharma AN, Fries GR, Galvez JF, Valvassori SS, Soares JC, Carvalho AF, Quevedo J (2016) Modeling mania in preclinical settings: a comprehensive review. Prog Neuropsychopharmacol Biol Psych 66:22\u201334. https:\/\/doi.org\/10.1016\/j.pnpbp.2015.11.001","journal-title":"Prog Neuropsychopharmacol Biol Psych"},{"key":"776_CR105","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10787-017-0402-8","volume":"26","author":"N Sharma","year":"2018","unstructured":"Sharma N, Nehru B (2018) Curcumin affords neuroprotection and inhibits a-synuclein aggregation in lipopolysaccharide-induced Parkinson\u2019s disease model. Inflammopharmacology 26:349\u2013360. https:\/\/doi.org\/10.1007\/s10787-017-0402-8","journal-title":"Inflammopharmacology"},{"key":"776_CR106","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.bbagen.2009.07.026","volume":"1790","author":"KP Shay","year":"2009","unstructured":"Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM (2009) Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 1790:1149\u20131160. https:\/\/doi.org\/10.1016\/j.bbagen.2009.07.026","journal-title":"Biochim Biophys Acta"},{"key":"776_CR107","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/pcn.12476","volume":"71","author":"E Sigitova","year":"2017","unstructured":"Sigitova E, Fi\u0161ar Z, Hroudov\u00e1 J, Cik\u00e1nkov\u00e1 T, Raboch J (2017) Biological hypotheses and biomarkers of bipolar disorder. Psychiatry Clin Neurosci 71:77\u2013103. https:\/\/doi.org\/10.1111\/pcn.12476","journal-title":"Psychiatry Clin Neurosci"},{"key":"776_CR108","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/cap.2014.0110","volume":"25","author":"EM Sikoglu","year":"2015","unstructured":"Sikoglu EM, Navarro AA, Starr D, Dvir Y, Nwosu BU, Czerniak SM, Rogan RC, Castro MC, Edden RA, Frazier JA, Moore CM (2015) Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders. J Child Adolesc Psychopharmacol 25:415\u2013424. https:\/\/doi.org\/10.1089\/cap.2014.0110","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"776_CR109","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/bdi.12640","volume":"21","author":"N Singh","year":"2019","unstructured":"Singh N, Mcmahon H, Bilderbeck A, Reed ZE, Tunbridge E, Brett D, Geddes JR, Churchill GC, Goodwin GM (2019) Plasma glutathione suggests oxidative stress is equally present in early-and late-onset bipolar disorder. Bipolar Disord 21:61\u201367. https:\/\/doi.org\/10.1111\/bdi.12640","journal-title":"Bipolar Disord"},{"key":"776_CR110","doi-asserted-by":"publisher","unstructured":"Slattery DJ, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R (2015) Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review. Neurosci Biobehav Rev 55:294\u2013321. https:\/\/doi.org\/10.1016\/j.neubiorev.2015.04.015","DOI":"10.1016\/j.neubiorev.2015.04.015"},{"issue":"8","key":"776_CR111","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/ptr.5642","volume":"30","author":"A Smeriglio","year":"2016","unstructured":"Smeriglio A, Barreca D, Bellocco E, Trombetta D (2016) Chemistry, pharmacology and health benefits of anthocyanins. Phytother Res 30(8):1265\u20131286. https:\/\/doi.org\/10.1002\/ptr.5642","journal-title":"Phytother Res"},{"key":"776_CR112","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/mp.2017.144","volume":"22","author":"M Song","year":"2017","unstructured":"Song M, Martinowich K, Lee FS (2017) BDNF at the synapse: why location matters. Mol Psychiatr 22:1370\u20131375","journal-title":"Mol Psychiatr"},{"issue":"605","key":"776_CR113","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s11011-018-0353-9","volume":"34","author":"L Spohr","year":"2019","unstructured":"Spohr L, Soares MSP, Oliveira P, Silveira B, Bona NP, Pedra NS, Teixeira FC, do Couto CAT, Reginatto FH, Lisboa M, Ribeiro AS, Lencina CL, Stefanello FM, Spanevello RM (2019) Combined actions of\u00a0blueberry\u00a0extract and lithium on neurochemical changes observed in an experimental model of\u00a0mania: exploiting possible synergistic effects. Metab Brain Dis 34(605):619. https:\/\/doi.org\/10.1007\/s11011-018-0353-9","journal-title":"Metab Brain Dis"},{"key":"776_CR114","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1080\/14737159.2016.1248413","volume":"16","author":"AL Teixeira","year":"2016","unstructured":"Teixeira AL, Salem H, Frey BN, Barbosa IG, Machado-Vieira R (2016) Update on bipolar disorder biomarker candidates. Exp Rev Mol Diagn 16:1209\u20131220. https:\/\/doi.org\/10.1080\/14737159.2016.1248413","journal-title":"Exp Rev Mol Diagn"},{"key":"776_CR115","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1001\/jama.301.5.564","volume":"301","author":"JM Torpy","year":"2009","unstructured":"Torpy JM, Lynm C, Glass RM (2009) Bipolar disorder. J Am Med Assoc 301:564","journal-title":"J Am Med Assoc"},{"key":"776_CR116","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1590\/1516-4446-2013-1168","volume":"35","author":"SS Valvassori","year":"2013","unstructured":"Valvassori SS, Budni J, Varela RB, Quevedo J (2013) Contributions of animal models to the study of mood disorders. Braz J Psychiatr 35:121\u2013131. https:\/\/doi.org\/10.1590\/1516-4446-2013-1168","journal-title":"Braz J Psychiatr"},{"key":"776_CR117","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1089\/cap.2013.0141","volume":"25","author":"AT Vesco","year":"2015","unstructured":"Vesco AT, Lehmann J, Gracious BL, Arnold LE, Young AS, Fristad MA (2015) Omega-3 supplementation for psychotic mania and comorbid anxiety in children. J Child Adolesc Psychopharmacol 25:526\u2013534. https:\/\/doi.org\/10.1089\/cap.2013.0141","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"776_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00427414","volume":"83","author":"P Willner","year":"1984","unstructured":"Willner P (1984) The validity of animal models of depression. Psychopharmacology 83:1\u201316","journal-title":"Psychopharmacology"},{"key":"776_CR119","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ejphar.2015.03.019","volume":"759","author":"JW Young","year":"2015","unstructured":"Young JW, Dulcis D (2015) Investigating the mechanism(s) underlying switching between states in bipolar disorder. Eur J Pharmacol 759:151\u2013162. https:\/\/doi.org\/10.1016\/j.ejphar.2015.03.019","journal-title":"Eur J Pharmacol"},{"key":"776_CR120","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.psychres.2019.02.051","volume":"274","author":"C Yu-Jie","year":"2019","unstructured":"Yu-Jie C, Tiao-Lai H (2019) Brain-derived neurotrophic factor (BDNF) and bipolar disorder. Psych Res 274:395\u2013399. https:\/\/doi.org\/10.1016\/j.psychres.2019.02.051","journal-title":"Psych Res"},{"key":"776_CR121","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jpsychires.2006.08.002","volume":"41","author":"ZJ Zhang","year":"2007","unstructured":"Zhang ZJ, Kang WH, Li Q, Tan QR (2007a) The beneficial effects of the herbal medicine free and easy wanderer Plus (FEWP) for mood disorders: double-blind, placebo-controlled studies. J Psychiatr Res 41:828\u2013836. https:\/\/doi.org\/10.1016\/j.jpsychires.2006.08.002","journal-title":"J Psychiatr Res"},{"key":"776_CR122","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jpsychires.2005.06.002","volume":"41","author":"ZJ Zhang","year":"2007","unstructured":"Zhang ZJ, Kang WH, Tan QR, Li Q, Gao CG, Zhang FG, Wang HH, Ma XC, Chen C, Wang W, Guo L, Zhang YH, Yang XB, Yang GD (2007b) Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study. J Psychiatr Res 41:360\u2013369. https:\/\/doi.org\/10.1016\/j.jpsychires.2005.06.002","journal-title":"J Psychiatr Res"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-021-00776-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-021-00776-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-021-00776-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T09:46:40Z","timestamp":1632131200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-021-00776-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":122,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["776"],"URL":"https:\/\/doi.org\/10.1007\/s11011-021-00776-7","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"30 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants by any of the authors. All studies performed by the authors with animals and cited in this manuscript has been previously published in accordance with the ethical standards of the institutional research guidelines for the care and use of animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}