{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:07:54Z","timestamp":1776215274297,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11011-022-00976-9","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T03:56:47Z","timestamp":1649303807000},"page":"1641-1654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SAM, a cystathionine beta-synthase activator, promotes hydrogen sulfide to promote neural repair resulting from massive cerebral infarction induced by middle cerebral artery occlusion"],"prefix":"10.1007","volume":"37","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"976_CR1","doi-asserted-by":"publisher","unstructured":"Bardgett ME, Chen QH, Guo Q, Calderon AS, Andrade MA, Toney GM (2014) Coping with dehydration: sympathetic activation and regulation of glutamatergic transmission in the hypothalamic PVN. Am J Physiol Regul Integr Comp Physiol 306(11) R804-R813.\u00a0https:\/\/doi.org\/10.1152\/ajpregu.00074.2014","DOI":"10.1152\/ajpregu.00074.2014"},{"key":"976_CR2","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s11596-011-0573-2","volume":"31","author":"D Chen","year":"2011","unstructured":"Chen D, Pan H, Li C, Lan X, Liu B, Yang G (2011) Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy. J Huazhong Univ Sci Technolog Med Sci 31:632. https:\/\/doi.org\/10.1007\/s11596-011-0573-2","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"976_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/14737175.2019.1668270","volume":"20","author":"M Chen","year":"2020","unstructured":"Chen M, Pritchard C, Fortune D, Kodi P, Grados M (2020) Hydrogen sulfide: a target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety. Expert Rev Neurother 20:109\u2013121. https:\/\/doi.org\/10.1080\/14737175.2019.1668270","journal-title":"Expert Rev Neurother"},{"key":"976_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1515\/revneuro-2014-0051","volume":"26","author":"WL Chen","year":"2015","unstructured":"Chen WL, Niu YY, Jiang WZ, Tang HL, Zhang C, Xia QM, Tang XQ (2015) Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways. Rev Neurosci 26:129\u2013142. https:\/\/doi.org\/10.1515\/revneuro-2014-0051","journal-title":"Rev Neurosci"},{"key":"976_CR5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s11910-013-0370-3","volume":"13","author":"HA Choi","year":"2013","unstructured":"Choi HA, Jeon SB, Samuel S, Allison T, Lee K (2013) Paroxysmal sympathetic hyperactivity after acute brain injury. Curr Neurol Neurosci Rep 13:370. https:\/\/doi.org\/10.1007\/s11910-013-0370-3","journal-title":"Curr Neurol Neurosci Rep"},{"key":"976_CR6","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ejphar.2018.07.001","volume":"833","author":"AK Datusalia","year":"2018","unstructured":"Datusalia AK, Agarwal P, Singh JN, Sharma SS (2018) Hyper-insulinemia increases the glutamate-excitotoxicity in cortical neurons: A mechanistic study. Eur J Pharmacol 833:524\u2013530. https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.001","journal-title":"Eur J Pharmacol"},{"key":"976_CR7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.redox.2016.01.008","volume":"8","author":"M Dziegelewska","year":"2016","unstructured":"Dziegelewska M et al (2016) Low sulfide levels and a high degree of cystathionine beta-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Redox Biol 8:192\u2013198. https:\/\/doi.org\/10.1016\/j.redox.2016.01.008","journal-title":"Redox Biol"},{"key":"976_CR8","doi-asserted-by":"publisher","first-page":"R165","DOI":"10.1186\/cc9257","volume":"14","author":"F Ganster","year":"2010","unstructured":"Ganster F et al (2010) Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats. Crit Care 14:R165. https:\/\/doi.org\/10.1186\/cc9257","journal-title":"Crit Care"},{"key":"976_CR9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.pneurobio.2005.10.008","volume":"77","author":"JJ Haddad","year":"2005","unstructured":"Haddad JJ (2005) N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention? Prog Neurobiol 77:252\u2013282. https:\/\/doi.org\/10.1016\/j.pneurobio.2005.10.008","journal-title":"Prog Neurobiol"},{"key":"976_CR10","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/j.sjbs.2017.11.027","volume":"24","author":"HT Huang","year":"2017","unstructured":"Huang HT, Sun ZG, Liu HW, Ma JT, Hu M (2017) ERK\/MAPK and PI3K\/AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury Saudi. J Biol Sci 24:1853\u20131858. https:\/\/doi.org\/10.1016\/j.sjbs.2017.11.027","journal-title":"J Biol Sci"},{"key":"976_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1089\/neu.2020.7552","volume":"39","author":"S Huerta de la Cruz","year":"2022","unstructured":"Huerta de la Cruz S, Rocha L, Santiago-Castaneda C, Sanchez-Lopez A, Pinedo-Rodriguez AD, Medina-Terol GJ, Centurion D (2022) Hydrogen Sulfide Subchronic Treatment Improves Hypertension Induced by Traumatic Brain Injury in Rats through Vasopressor Sympathetic Outflow Inhibition. J Neurotrauma 39:181\u2013195. https:\/\/doi.org\/10.1089\/neu.2020.7552","journal-title":"J Neurotrauma"},{"key":"976_CR12","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuint.2013.09.003","volume":"63","author":"H Kimura","year":"2013","unstructured":"Kimura H (2013) Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 63:492\u2013497. https:\/\/doi.org\/10.1016\/j.neuint.2013.09.003","journal-title":"Neurochem Int"},{"key":"976_CR13","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1523\/JNEUROSCI.4295-13.2014","volume":"34","author":"DP Li","year":"2014","unstructured":"Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL (2014) mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. J Neurosci 34:4309\u20134317. https:\/\/doi.org\/10.1523\/JNEUROSCI.4295-13.2014","journal-title":"J Neurosci"},{"key":"976_CR14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.toxlet.2017.02.004","volume":"270","author":"YF Liang","year":"2017","unstructured":"Liang YF et al (2017) Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension. Toxicol Lett 270:62\u201371. https:\/\/doi.org\/10.1016\/j.toxlet.2017.02.004","journal-title":"Toxicol Lett"},{"key":"976_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/cvr\/cvr009","volume":"90","author":"S Lim","year":"2011","unstructured":"Lim S et al (2011) Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats. Cardiovasc Res 90:383\u2013393. https:\/\/doi.org\/10.1093\/cvr\/cvr009","journal-title":"Cardiovasc Res"},{"key":"976_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229499","volume":"15","author":"CW Liu","year":"2020","unstructured":"Liu CW, Liao KH, Tseng H, Wu CM, Chen HY, Lai TW (2020) Hypothermia but not NMDA receptor antagonism protects against stroke induced by distal middle cerebral arterial occlusion in mice. PLoS ONE 15:e0229499. https:\/\/doi.org\/10.1371\/journal.pone.0229499","journal-title":"PLoS ONE"},{"key":"976_CR17","doi-asserted-by":"publisher","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84\u201391. https:\/\/doi.org\/10.1161\/01.str.20.1.84","DOI":"10.1161\/01.str.20.1.84"},{"key":"976_CR18","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s11910-014-0494-0","volume":"14","author":"D Lump","year":"2014","unstructured":"Lump D, Moyer M (2014) Paroxysmal sympathetic hyperactivity after severe brain injury. Curr Neurol Neurosci Rep 14:494. https:\/\/doi.org\/10.1007\/s11910-014-0494-0","journal-title":"Curr Neurol Neurosci Rep"},{"key":"976_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.brainres.2016.05.001","volume":"1643","author":"NL Machado","year":"2016","unstructured":"Machado NL, Silva FC, Chianca DA Jr, de Menezes RC (2016) Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats. Brain Res 1643:159\u2013167. https:\/\/doi.org\/10.1016\/j.brainres.2016.05.001","journal-title":"Brain Res"},{"key":"976_CR20","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1474-4422(17)30259-4","volume":"16","author":"G Meyfroidt","year":"2017","unstructured":"Meyfroidt G, Baguley IJ, Menon DK (2017) Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurol 16:721\u2013729. https:\/\/doi.org\/10.1016\/S1474-4422(17)30259-4","journal-title":"Lancet Neurol"},{"key":"976_CR21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrm3391","volume":"13","author":"BD Paul","year":"2012","unstructured":"Paul BD, Snyder SH (2012) H(2)S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol 13:499\u2013507. https:\/\/doi.org\/10.1038\/nrm3391","journal-title":"Nat Rev Mol Cell Biol"},{"key":"976_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bcp.2017.11.019","volume":"149","author":"BD Paul","year":"2018","unstructured":"Paul BD, Snyder SH (2018) Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol 149:101\u2013109. https:\/\/doi.org\/10.1016\/j.bcp.2017.11.019","journal-title":"Biochem Pharmacol"},{"key":"976_CR23","doi-asserted-by":"publisher","first-page":"394","DOI":"10.4103\/1673-5374.266045","volume":"15","author":"A Popa-Wagner","year":"2020","unstructured":"Popa-Wagner A, Dumitrascu DI, Capitanescu B, Petcu EB, Surugiu R, Fang WH, Dumbrava DA (2020) Dietary habits, lifestyle factors and neurodegenerative diseases. Neural Regen Res 15:394\u2013400. https:\/\/doi.org\/10.4103\/1673-5374.266045","journal-title":"Neural Regen Res"},{"key":"976_CR24","doi-asserted-by":"publisher","unstructured":"Pushchina EV, Zharikova EI, Varaksin AA (2021) Mechanical Brain Injury Increases Cells' Production of Cystathionine beta-Synthase and Glutamine Synthetase, but Reduces Pax2 Expression in the Telencephalon of Juvenile Chum Salmon, Oncorhynchus keta Int J Mol Sci 22 https:\/\/doi.org\/10.3390\/ijms22031279","DOI":"10.3390\/ijms22031279"},{"key":"976_CR25","doi-asserted-by":"publisher","first-page":"8039","DOI":"10.26355\/eurrev_201909_19020","volume":"23","author":"YL Shi","year":"2019","unstructured":"Shi YL, Wang Q, Wei JC (2019) Influence of lncRNA-MALAT1 on neuronal apoptosis in rats with cerebral infarction through regulating the ERK\/MAPK signaling pathway. Eur Rev Med Pharmacol Sci 23:8039\u20138048. https:\/\/doi.org\/10.26355\/eurrev_201909_19020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"976_CR26","doi-asserted-by":"publisher","first-page":"112520","DOI":"10.1016\/j.bbr.2020.112520","volume":"384","author":"YJ Song","year":"2020","unstructured":"Song YJ et al (2020) H2S attenuates injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module. Behav Brain Res 384:112520. https:\/\/doi.org\/10.1016\/j.bbr.2020.112520","journal-title":"Behav Brain Res"},{"key":"976_CR27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/01.nrl.0000159987.70461.d7","volume":"11","author":"S Subramaniam","year":"2005","unstructured":"Subramaniam S, Hill MD (2005) Massive Cerebral Infarction Neurologist 11:150\u2013160. https:\/\/doi.org\/10.1097\/01.nrl.0000159987.70461.d7","journal-title":"Massive Cerebral Infarction Neurologist"},{"key":"976_CR28","doi-asserted-by":"publisher","first-page":"7180","DOI":"10.18632\/aging.202575","volume":"13","author":"J Sun","year":"2021","unstructured":"Sun J, Li X, Gu X, Du H, Zhang G, Wu J, Wang F (2021) Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53\/glutaminase 2 pathway after traumatic brain injury. Aging (Albany NY) 13:7180\u20137189. https:\/\/doi.org\/10.18632\/aging.202575","journal-title":"Aging (Albany NY)"},{"key":"976_CR29","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12640-010-9180-4","volume":"19","author":"XQ Tang","year":"2011","unstructured":"Tang XQ et al (2011) Inhibition of hydrogen sulfide generation contributes to 1-methy-4-phenylpyridinium ion-induced neurotoxicity. Neurotox Res 19:403\u2013411. https:\/\/doi.org\/10.1007\/s12640-010-9180-4","journal-title":"Neurotox Res"},{"key":"976_CR30","doi-asserted-by":"publisher","first-page":"S191","DOI":"10.33549\/physiolres.932678","volume":"63","author":"V Vyklicky","year":"2014","unstructured":"Vyklicky V et al (2014) Structure, function, and pharmacology of NMDA receptor channels. Physiol Res 63:S191-203. https:\/\/doi.org\/10.33549\/physiolres.932678","journal-title":"Physiol Res"},{"key":"976_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrd4433","volume":"14","author":"JL Wallace","year":"2015","unstructured":"Wallace JL, Wang R (2015) Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov 14:329\u2013345. https:\/\/doi.org\/10.1038\/nrd4433","journal-title":"Nat Rev Drug Discov"},{"key":"976_CR32","doi-asserted-by":"publisher","first-page":"F1077","DOI":"10.1152\/ajprenal.00526.2017","volume":"314","author":"W Wang","year":"2018","unstructured":"Wang W et al (2018) Endogenous H2S sensitizes PAR4-induced bladder pain. Am J Physiol Renal Physiol 314:F1077\u2013F1086. https:\/\/doi.org\/10.1152\/ajprenal.00526.2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"976_CR33","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.brainres.2015.07.001","volume":"1622","author":"X Wei","year":"2015","unstructured":"Wei X et al (2015) Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. Brain Res 1622:292\u2013299. https:\/\/doi.org\/10.1016\/j.brainres.2015.07.001","journal-title":"Brain Res"},{"key":"976_CR34","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3892\/ijmm.2017.3035","volume":"40","author":"R Zhang","year":"2017","unstructured":"Zhang R, Lin YQ, Wang WS, Wang XQ (2017) Excessive nNOS\/NO\/AMPK signaling activation mediated by the blockage of the CBS\/H2S system contributes to oxygenglucose deprivationinduced endoplasmic reticulum stress in PC12 cells. Int J Mol Med 40:549\u2013557. https:\/\/doi.org\/10.3892\/ijmm.2017.3035","journal-title":"Int J Mol Med"},{"key":"976_CR35","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.3892\/or.2015.4248","volume":"34","author":"Y Zhen","year":"2015","unstructured":"Zhen Y et al (2015) Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK\/ERK1\/2-COX-2 pathways. Oncol Rep 34:2413\u20132422. https:\/\/doi.org\/10.3892\/or.2015.4248","journal-title":"Oncol Rep"},{"key":"976_CR36","doi-asserted-by":"publisher","first-page":"e0149965","DOI":"10.1371\/journal.pone.0149965","volume":"11","author":"Q Zhu","year":"2016","unstructured":"Zhu Q et al (2016) MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2. PLoS One 11:e0149965. https:\/\/doi.org\/10.1371\/journal.pone.0149965","journal-title":"PLoS One"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-00976-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-00976-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-00976-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T06:17:24Z","timestamp":1652854644000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-00976-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["976"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-00976-9","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,7]]},"assertion":[{"value":"12 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest is declared by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by Medical Ethics committee of the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine and was implemented following the principles of the <i>Declaration of Helsinki<\/i>. All enrolled donors provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}