{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:01:58Z","timestamp":1787580118087,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004843","name":"Manipal University","doi-asserted-by":"publisher","award":["MCOPS\/IMF\/2019"],"award-info":[{"award-number":["MCOPS\/IMF\/2019"]}],"id":[{"id":"10.13039\/501100004843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","award":["School of Pharmacy"],"award-info":[{"award-number":["School of Pharmacy"]}],"id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","award":["Pharmacology Research Fund 2018"],"award-info":[{"award-number":["Pharmacology Research Fund 2018"]}],"id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NAD<jats:sup>+<\/jats:sup>\u2014dependent histone deacetylases (sirtuins 1\u20137) have been shown to be involved in various pathophysiological conditions including their involvement in cardiovascular, cancerous, neurodegenerative, immune dysregulation and inflammatory conditions. This study investigates the inflammomodulatory potential of resveratrol (RES), a sirtuin activator and sirtinol (SIR), a sirtuin inhibitor in lipopolysaccharide (LPS)-induced model of sickness behaviour in mice. Male Swiss albino mice were divided into five groups (n\u2009=\u20096) consisting of saline (SAL), LPS, RES, SIR, and fluoxetine (FLU) respectively, each group except LPS was prepared by intraperitoneally (i.p.) administration of SAL (10\u00a0mL\/kg), RES (50\u00a0mg\/kg), SIR (2\u00a0mg\/kg) and FLU (10\u00a0mg\/kg). Thirty minutes after the treatments, all the groups, except SAL were administered LPS (2\u00a0mg\/kg, i.p.). The behavioural assays including, open field test, forced swim test, and tail suspension tests were conducted 1\u00a0h after LPS challenge. LPS administration significantly reduced the locomotor activity along with inducing a state of high immobility and that was prevented by pretreatment with RES and SIR. Further, various proinflammatory cytokines (TNF-\u03b1, IL-6, and IL-1\u03b2), and oxidative stress markers (MDA and GSH) were found to be significantly elevated in the brain homogenates after LPS treatment. SIR pretreatment abrogated the LPS-induced neuroinflammatory and oxidative stress changes, whereas RES was only effective in reducing the oxidative stress and TNF-\u03b1 levels. The results of this study speculate that the role of SIRT modulators in neuroinflammatory conditions could vary with their dose, regimen and chemical properties. Further studies with detailed molecular and pharmacokinetic profiling will be needed to explore their therapeutic potentials.<\/jats:p>","DOI":"10.1007\/s11011-022-00992-9","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T09:05:25Z","timestamp":1652346325000},"page":"1969-1976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice"],"prefix":"10.1007","volume":"37","author":[{"given":"Manas","family":"Kinra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraja","family":"Ranadive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh","family":"Mudgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Govindula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Anoopkumar-Dukie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavan","family":"Nampoothiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-7769","authenticated-orcid":false,"given":"Devinder","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"992_CR1","doi-asserted-by":"publisher","unstructured":"Basu Mallik S, Mudgal J, Hall S, Kinra M, Grant GD, Nampoothiri M, Anoopkumar-Dukie S, Arora D (2021) Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF. Nutr Neurosci 1-9. https:\/\/doi.org\/10.1080\/1028415X.2021.1906393","DOI":"10.1080\/1028415X.2021.1906393"},{"key":"992_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.neulet.2016.08.044","volume":"632","author":"S Basu Mallik","year":"2016","unstructured":"Basu Mallik S, Mudgal J, Nampoothiri M, Hall S, Dukie SA, Grant G, Rao CM, Arora D (2016) Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice. Neurosci Lett 632:218\u2013223. https:\/\/doi.org\/10.1016\/j.neulet.2016.08.044","journal-title":"Neurosci Lett"},{"key":"992_CR3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1741-7015-11-200","volume":"11","author":"M Berk","year":"2013","unstructured":"Berk M, Williams LJ, Jacka FN, O\u2019Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200. https:\/\/doi.org\/10.1186\/1741-7015-11-200","journal-title":"BMC Med"},{"key":"992_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jep.2013.06.004","volume":"149","author":"MC B\u00fafalo","year":"2013","unstructured":"B\u00fafalo MC, Ferreira I, Costa G, Francisco V, Liberal J, Cruz MT, Lopes MC, Batista MT, Sforcin JM (2013) Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-\u03baB and MAPK activation in macrophages. J Ethnopharmacol 149:84\u201392. https:\/\/doi.org\/10.1016\/j.jep.2013.06.004","journal-title":"J Ethnopharmacol"},{"key":"992_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/WNR.0000000000000305","volume":"26","author":"H Chen","year":"2015","unstructured":"Chen H, Wu D, Ding X, Ying W (2015) SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia. NeuroReport 26:88\u201393. https:\/\/doi.org\/10.1097\/WNR.0000000000000305","journal-title":"NeuroReport"},{"key":"992_CR6","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nature14659","volume":"523","author":"CONVERGE consortium","year":"2015","unstructured":"CONVERGE consortium (2015) Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 523:588\u2013591. https:\/\/doi.org\/10.1038\/nature14659","journal-title":"Nature"},{"key":"992_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.iac.2009.02.002","volume":"29","author":"R Dantzer","year":"2009","unstructured":"Dantzer R (2009) Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am 29:247\u2013264. https:\/\/doi.org\/10.1016\/j.iac.2009.02.002","journal-title":"Immunol Allergy Clin North Am"},{"issue":"Suppl 2","key":"992_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/jnc.13607","volume":"139","author":"DJ DiSabato","year":"2016","unstructured":"DiSabato DJ, Quan N, Godbout JP (2016) Neuroinflammation: the devil is in the details. J Neurochem 139(Suppl 2):136\u2013153. https:\/\/doi.org\/10.1111\/jnc.13607","journal-title":"J Neurochem"},{"key":"992_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/937051","volume":"2014","author":"Y Fong","year":"2014","unstructured":"Fong Y, Lin YC, Wu CY, Wang HM, Lin LL, Chou HL, Teng YN, Yuan SS, Chiu CC (2014) The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt\/\u03b2-catenin-Foxo3a axis. ScientificWorldJournal 2014:937051. https:\/\/doi.org\/10.1155\/2014\/937051","journal-title":"ScientificWorldJournal"},{"key":"992_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109521","volume":"68","author":"S Ghosh","year":"2020","unstructured":"Ghosh S, Choudhury S, Chowdhury O, Mukherjee S, Das A, Sain A, Gupta P, Adhikary A, Chattopadhyay S (2020) Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine. Cell Signal 68:109521. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109521","journal-title":"Cell Signal"},{"key":"992_CR11","doi-asserted-by":"publisher","first-page":"F542","DOI":"10.1152\/ajprenal.00437.2013","volume":"306","author":"KL Gordish","year":"2014","unstructured":"Gordish KL, Beierwaltes WH (2014) Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging. Am J Physiol Renal Physiol 306:F542\u2013F550. https:\/\/doi.org\/10.1152\/ajprenal.00437.2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"992_CR12","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/cancers13040634","volume":"13","author":"R Jenke","year":"2021","unstructured":"Jenke R, Re\u00dfing N, Hansen FK, Aigner A, B\u00fcch T (2021) Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives. Cancers (Basel) 13:634. https:\/\/doi.org\/10.3390\/cancers13040634","journal-title":"Cancers (Basel)"},{"key":"992_CR13","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s11064-016-2110-y","volume":"42","author":"H J\u0119\u015bko","year":"2017","unstructured":"J\u0119\u015bko H, Wencel P, Strosznajder RP, Strosznajder JB (2017) Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. Neurochem Res 42:876\u2013890. https:\/\/doi.org\/10.1007\/s11064-016-2110-y","journal-title":"Neurochem Res"},{"key":"992_CR14","doi-asserted-by":"publisher","unstructured":"Jiao F, Gong Z (2020) The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. Oxid Med Cell Longev :6782872. https:\/\/doi.org\/10.1155\/2020\/6782872.","DOI":"10.1155\/2020\/6782872"},{"key":"992_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000350435","volume":"98","author":"YH Jing","year":"2013","unstructured":"Jing YH, Chen KH, Kuo PC, Pao CC, Chen JK (2013) Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol. Neuroendocrinology 98:116\u2013127. https:\/\/doi.org\/10.1159\/000350435","journal-title":"Neuroendocrinology"},{"key":"992_CR16","doi-asserted-by":"publisher","first-page":"8441","DOI":"10.1523\/JNEUROSCI.0212-16.2016","volume":"36","author":"HD Kim","year":"2016","unstructured":"Kim HD, Hesterman J, Call T, Magazu S, Keeley E, Armenta K, Kronman H, Neve RL, Nestler EJ, Ferguson D (2016) SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. J Neurosci 36:8441\u20138452. https:\/\/doi.org\/10.1523\/JNEUROSCI.0212-16.2016","journal-title":"J Neurosci"},{"key":"992_CR17","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1002\/jcb.24062","volume":"113","author":"IT Kim","year":"2012","unstructured":"Kim IT, Ryu S, Shin JS, Choi JH, Park HJ, Lee KT (2012) Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-\u03baB inactivation in RAW 264.7 macrophages. J Cell Biochem 113:1936\u20131946. https:\/\/doi.org\/10.1002\/jcb.24062","journal-title":"J Cell Biochem"},{"key":"992_CR18","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.bbrc.2014.06.135","volume":"450","author":"AS Lee","year":"2014","unstructured":"Lee AS, Jung YJ, Kim D, Nguyen-Thanh T, Kang KP, Lee S, Park SK, Kim W (2014) SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages. Biochem Biophys Res Commun 450:1363\u20131369. https:\/\/doi.org\/10.1016\/j.bbrc.2014.06.135","journal-title":"Biochem Biophys Res Commun"},{"key":"992_CR19","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.bbamcr.2013.03.004","volume":"1833","author":"J Lugrin","year":"2013","unstructured":"Lugrin J, Ciarlo E, Santos A, Grandmaison G, dos Santos I, Le Roy D, Roger T (2013) The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta 1833:1498\u20131510. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.03.004","journal-title":"Biochim Biophys Acta"},{"key":"992_CR20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1741-7015-10-66","volume":"10","author":"M Maes","year":"2012","unstructured":"Maes M, Berk M, Goehler L, Song C, Anderson G, Ga\u0142ecki P, Leonard B (2012) Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med 10:66. https:\/\/doi.org\/10.1186\/1741-7015-10-66","journal-title":"BMC Med"},{"key":"992_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/ni.2865","volume":"15","author":"J Mauer","year":"2014","unstructured":"Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Br\u00f6nneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Br\u00fcning JC (2014) Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 15:423\u2013430. https:\/\/doi.org\/10.1038\/ni.2865","journal-title":"Nat Immunol"},{"key":"992_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.joca.2012.11.017","volume":"21","author":"MH Moon","year":"2013","unstructured":"Moon MH, Jeong JK, Lee YJ, Seol JW, Jackson CJ, Park SY (2013) SIRT1, a class III histone deacetylase, regulates TNF-\u03b1-induced inflammation in human chondrocytes. Osteoarthritis Cartilage 21:470\u2013480. https:\/\/doi.org\/10.1016\/j.joca.2012.11.017","journal-title":"Osteoarthritis Cartilage"},{"key":"992_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169446","volume":"12","author":"MM Moraes","year":"2017","unstructured":"Moraes MM, Galv\u00e3o MC, Cabral D, Coelho CP, Queiroz-Hazarbassanov N, Martins MF, Bondan EF, Bernardi MM, Kirsten TB (2017) Propentofylline Prevents Sickness Behavior and Depressive-Like Behavior Induced by Lipopolysaccharide in Rats via Neuroinflammatory Pathway. PLoS ONE 12:e0169446. https:\/\/doi.org\/10.1371\/journal.pone.0169446","journal-title":"PLoS ONE"},{"key":"992_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104393","volume":"366","author":"VP Mourits","year":"2021","unstructured":"Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Heijden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG (2021) The role of sirtuin 1 on the induction of trained immunity. Cell Immunol 366:104393. https:\/\/doi.org\/10.1016\/j.cellimm.2021.104393","journal-title":"Cell Immunol"},{"key":"992_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103638","volume":"64","author":"J Mudgal","year":"2020","unstructured":"Mudgal J, Basu Mallik S, Nampoothiri M, Kinra M, Hall S, Grant GD, Anoopkumar-Dukie S, Davey AK, Rao CM, Arora D (2020) Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice. J Funct Foods 64:103638. https:\/\/doi.org\/10.1016\/j.jff.2019.103638","journal-title":"J Funct Foods"},{"key":"992_CR26","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s10787-019-00638-w","volume":"27","author":"J Mudgal","year":"2019","unstructured":"Mudgal J, Nampoothiri M, Basu Mallik S, Kinra M, Hall S, Grant G, Anoopkumar-Dukie S, Rao CM, Arora D (2019) Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice. Inflammopharmacology 27:941\u2013948. https:\/\/doi.org\/10.1007\/s10787-019-00638-w","journal-title":"Inflammopharmacology"},{"key":"992_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024307","volume":"6","author":"A Orecchia","year":"2011","unstructured":"Orecchia A, Scarponi C, Di Felice F, Cesarini E, Avitabile S, Mai A, Mauro ML, Sirri V, Zambruno G, Albanesi C, Camilloni G, Failla CM (2011) Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS ONE 6:e24307. https:\/\/doi.org\/10.1371\/journal.pone.0024307","journal-title":"PLoS ONE"},{"key":"992_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020719","volume":"6","author":"E Painsipp","year":"2011","unstructured":"Painsipp E, K\u00f6fer MJ, Sinner F, Holzer P (2011) Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment. PLoS ONE 6:e20719. https:\/\/doi.org\/10.1371\/journal.pone.0020719","journal-title":"PLoS ONE"},{"key":"992_CR29","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.bbadis.2011.03.008","volume":"1812","author":"P Palsamy","year":"2011","unstructured":"Palsamy P, Subramanian S (2011) Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Biochim Biophys Acta 1812:719\u2013731. https:\/\/doi.org\/10.1016\/j.bbadis.2011.03.008","journal-title":"Biochim Biophys Acta"},{"key":"992_CR30","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12035-013-8459-x","volume":"48","author":"AF Para\u00edso","year":"2013","unstructured":"Para\u00edso AF, Mendes KL, Santos SH (2013) Brain activation of SIRT1: role in neuropathology. Mol Neurobiol 48:681\u2013689. https:\/\/doi.org\/10.1007\/s12035-013-8459-x","journal-title":"Mol Neurobiol"},{"key":"992_CR31","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","volume":"1852","author":"EJ Park","year":"2015","unstructured":"Park EJ, Pezzuto JM (2015) The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta 1852:1071\u20131113. https:\/\/doi.org\/10.1016\/j.bbadis.2015.01.014","journal-title":"Biochim Biophys Acta"},{"key":"992_CR32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/mnfr.200400099","volume":"49","author":"N Richard","year":"2005","unstructured":"Richard N, Porath D, Radspieler A, Schwager J (2005) Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res 49:431\u2013442. https:\/\/doi.org\/10.1002\/mnfr.200400099","journal-title":"Mol Nutr Food Res"},{"key":"992_CR33","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1007\/s00213-019-5166-y","volume":"236","author":"P Sahu","year":"2019","unstructured":"Sahu P, Mudgal J, Arora D, Kinra M, Mallik SB, Rao CM, Pai KSR, Nampoothiri M (2019) Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice. Psychopharmacology 236:1829\u20131838. https:\/\/doi.org\/10.1007\/s00213-019-5166-y","journal-title":"Psychopharmacology"},{"key":"992_CR34","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1517\/13543784.2012.696609","volume":"21","author":"IP Salt","year":"2012","unstructured":"Salt IP, Palmer TM (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opin Investig Drugs 21:1155\u20131167. https:\/\/doi.org\/10.1517\/13543784.2012.696609","journal-title":"Expert Opin Investig Drugs"},{"key":"992_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s12906-017-1823-z","volume":"17","author":"J Schwager","year":"2017","unstructured":"Schwager J, Richard N, Widmer F, Raederstorff D (2017) Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells. BMC Complement Altern Med 17:309. https:\/\/doi.org\/10.1186\/s12906-017-1823-z","journal-title":"BMC Complement Altern Med"},{"key":"992_CR36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","volume":"32","author":"MR Shakespear","year":"2011","unstructured":"Shakespear MR, Halili MA, Irvine KM, Fairlie DP, Sweet MJ (2011) Histone deacetylases as regulators of inflammation and immunity. Trends Immunol 32:335\u2013343. https:\/\/doi.org\/10.1016\/j.it.2011.04.001","journal-title":"Trends Immunol"},{"key":"992_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2018.04.050","volume":"349","author":"J Shen","year":"2018","unstructured":"Shen J, Xu L, Qu C, Sun H, Zhang J (2018) Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1\/miR-134 signalling pathway regulates CREB\/BDNF expression in hippocampus in vivo and in vitro. Behav Brain Res 349:1\u20137. https:\/\/doi.org\/10.1016\/j.bbr.2018.04.050","journal-title":"Behav Brain Res"},{"key":"992_CR38","doi-asserted-by":"publisher","first-page":"8347","DOI":"10.1038\/srep08347","volume":"5","author":"YF Tsai","year":"2015","unstructured":"Tsai YF, Yu HP, Chang WY, Liu FC, Huang ZC, Hwang TL (2015) Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep 5:8347. https:\/\/doi.org\/10.1038\/srep08347","journal-title":"Sci Rep"},{"key":"992_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","volume":"60","author":"A Varatharaj","year":"2017","unstructured":"Varatharaj A, Galea I (2017) The blood-brain barrier in systemic inflammation. Brain Behav Immun 60:1\u201312. https:\/\/doi.org\/10.1016\/j.bbi.2016.03.010","journal-title":"Brain Behav Immun"},{"key":"992_CR40","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/mc.21906","volume":"52","author":"TT Wang","year":"2013","unstructured":"Wang TT, Schoene NW, Kim EK, Kim YS (2013) Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP. Mol Carcinog 52:676\u2013685. https:\/\/doi.org\/10.1002\/mc.21906","journal-title":"Mol Carcinog"},{"key":"992_CR41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1868-7083-5-10","volume":"5","author":"D Wendling","year":"2013","unstructured":"Wendling D, Abbas W, Godfrin-Valnet M, Guillot X, Khan KA, Cedoz JP, Baud L, Prati C, Herbein G (2013) Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis. Clin Epigenetics 5:10. https:\/\/doi.org\/10.1186\/1868-7083-5-10","journal-title":"Clin Epigenetics"},{"key":"992_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080905","volume":"8","author":"A Wiesinger","year":"2013","unstructured":"Wiesinger A, Peters W, Chappell D, Kentrup D, Reuter S, Pavenst\u00e4dt H, Oberleithner H, K\u00fcmpers P (2013) Nanomechanics of the endothelial glycocalyx in experimental sepsis. PLoS ONE 8:e80905. https:\/\/doi.org\/10.1371\/journal.pone.0080905","journal-title":"PLoS ONE"},{"key":"992_CR43","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1093\/jn\/128.12.2334","volume":"128","author":"F Yang","year":"1998","unstructured":"Yang F, de Villiers WJ, McClain CJ, Varilek GW (1998) Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model. J Nutr 128:2334\u20132340. https:\/\/doi.org\/10.1093\/jn\/128.12.2334","journal-title":"J Nutr"},{"key":"992_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172847","volume":"867","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Anoopkumar-Dukie S, Arora D, Davey AK (2020) Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. Eur J Pharmacol 867:172847. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172847","journal-title":"Eur J Pharmacol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-00992-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-00992-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-00992-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T17:30:43Z","timestamp":1657819843000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-00992-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["992"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-00992-9","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"9 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest associated with this publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}