{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:36:15Z","timestamp":1782779775955,"version":"3.54.5"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11011-022-01006-4","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T11:03:01Z","timestamp":1654513381000},"page":"2067-2075","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Possible involvement of NO-cGMP signaling in the antidepressant like Effect of Amantadine in mice"],"prefix":"10.1007","volume":"37","author":[{"given":"Sushma","family":"Maratha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-3495","authenticated-orcid":false,"given":"Vaibhav","family":"Walia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"1006_CR1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.bbr.2005.11.023","volume":"168","author":"RC Almeida","year":"2006","unstructured":"Almeida RC, Felisbino CS, Lopez MG, Rodrigues AL, Gabilan NH (2006) Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice. Behav Brain Res 168:318\u2013322. doi: https:\/\/doi.org\/10.1016\/j.bbr.2005.11.023","journal-title":"Behav Brain Res"},{"key":"1006_CR2","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1007\/BF00390373","volume-title":"Methods of enzymatic analysis","author":"E Bernt","year":"1965","unstructured":"Bernt E, Bergmeyer HU (1965) L-glutamate UV assay with glutamate dehydrogenase and NAD. Methods of enzymatic analysis, 2nd edn. Academic Press, New York, pp 1704\u20131708. https:\/\/doi.org\/10.1007\/BF00390373","edition":"2"},{"issue":"2","key":"1006_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.tox.2004.11.034","volume":"208","author":"A Bishop","year":"2005","unstructured":"Bishop A, Anderson JE (2005) NO signaling in the CNS: from the physiological to the pathological. Toxicology 208(2):193\u2013205. doi: https:\/\/doi.org\/10.1016\/j.tox.2004.11.034","journal-title":"Toxicology"},{"issue":"13","key":"1006_CR4","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1523\/JNEUROSCI.4262-04.2005","volume":"25","author":"TA Blanpied","year":"2005","unstructured":"Blanpied TA, Clarke RJ, Johnson JW (2005) Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci 25(13):3312\u20133322. doi: https:\/\/doi.org\/10.1523\/JNEUROSCI.4262-04.2005","journal-title":"J Neurosci"},{"issue":"1","key":"1006_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresrev.2005.03.006","volume":"50","author":"A C\u00e1rdenas","year":"2005","unstructured":"C\u00e1rdenas A, Moro MA, Hurtado O, Leza JC, Lizasoain I (2005) Dual role of nitric oxide in adult neurogenesiss. Brain Res Brain Res Rev 50(1):1\u20136. doi: https:\/\/doi.org\/10.1016\/j.brainresrev.2005.03.006","journal-title":"Brain Res Brain Res Rev"},{"key":"1006_CR6","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1523\/JNeurosci","volume":"12","author":"HS Chen","year":"1992","unstructured":"Chen HS, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA (1992) Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci 12:4427\u20134436. doi: https:\/\/doi.org\/10.1523\/JNeurosci","journal-title":"J Neurosci"},{"issue":"2","key":"1006_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1590\/s0100-879x2009000200007","volume":"42","author":"RE de Bittencourt-Navarrete","year":"2009","unstructured":"de Bittencourt-Navarrete RE, do Nascimento IC, Santiago MF, Mendez-Otero R (2009) NMDA receptor blockade alters the intracellular distribution of neuronal nitric oxide synthase in the superficial layers of the rat superior colliculus. Braz J Med Biol Res 42(2):189\u2013196. doi: https:\/\/doi.org\/10.1590\/s0100-879x2009000200007","journal-title":"Braz J Med Biol Res"},{"key":"1006_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ejphar.2007.04.028","volume":"568","author":"A Dhir","year":"2007","unstructured":"Dhir A, Kulkarni SK (2007) Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor. Eur J Pharmacol 568:177\u2013185. doi: https:\/\/doi.org\/10.1016\/j.ejphar.2007.04.028","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1006_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.niox.2011.02.002","volume":"24","author":"A Dhir","year":"2011","unstructured":"Dhir A, Kulkarni SK (2011) Nitric oxide, and major depression. Nitric Oxide 24(3):125\u2013131. doi: https:\/\/doi.org\/10.1016\/j.niox.2011.02.002","journal-title":"Nitric Oxide"},{"issue":"6","key":"1006_CR10","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.euroneuro.2016.03.006","volume":"26","author":"D Downey","year":"2016","unstructured":"Downey D, Dutta A, McKie S, Dawson GR, Dourish CT, Craig K, Smith MA, McCarthy DJ, Harmer CJ, Goodwin GM, Williams S (2016) Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. Eur Neuropsychopharmacol 26(6):994\u20131003. doi: https:\/\/doi.org\/10.1016\/j.euroneuro.2016.03.006","journal-title":"Eur Neuropsychopharmacol"},{"issue":"1\u20132","key":"1006_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.brainres.2004.12.045","volume":"1036","author":"S Erceg","year":"2005","unstructured":"Erceg S, Monfort P, Hernandez-Viadel M, Llansola M, Montoliu C, Felipo V (2005) Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res 1036(1\u20132):115\u2013121. doi: https:\/\/doi.org\/10.1016\/j.brainres.2004.12.045","journal-title":"Brain Res"},{"key":"1006_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4103\/amhs.amhs_7_18","volume":"6","author":"OJ Fasipe","year":"2018","unstructured":"Fasipe OJ (2018) Neuropharmacological classification of antidepressant agents based on their mechanisms of action. Arch Med Health Sci 6:81. doi: https:\/\/doi.org\/10.4103\/amhs.amhs_7_18","journal-title":"Arch Med Health Sci"},{"key":"1006_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.euroneuro.2007.07.011","volume":"18","author":"M Ghasemi","year":"2008","unstructured":"Ghasemi M, Sadeghipour H, Mosleh A, Sadeghipour HR, Mani AR, Dehpour AR (2008) Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharmacol 18:323\u2013332. doi: https:\/\/doi.org\/10.1016\/j.euroneuro.2007.07.011","journal-title":"Eur Neuropsychopharmacol"},{"key":"1006_CR14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-x","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15\u00a0N] nitrate in biological fluids. Anal Biochem 126:131\u2013138. doi: https:\/\/doi.org\/10.1016\/0003-2697(82)90118-x","journal-title":"Anal Biochem"},{"key":"1006_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.pneurobio.2005.06.001","volume":"76","author":"FX Guix","year":"2005","unstructured":"Guix FX, Uribesalgo I, Coma M, Munoz FJ (2005) The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76:126\u2013152. doi: https:\/\/doi.org\/10.1016\/j.pneurobio.2005.06.001","journal-title":"Prog Neurobiol"},{"key":"1006_CR16","doi-asserted-by":"publisher","first-page":"164943","DOI":"10.1155\/2015\/164943","volume":"2015","author":"G Gupta","year":"2015","unstructured":"Gupta G, Jia Jia T, Yee Woon L, Kumar Chellappan D, Candasamy M, Dua K (2015) Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Adv Pharmacol Sci 2015:164943. doi: https:\/\/doi.org\/10.1155\/2015\/164943","journal-title":"Adv Pharmacol Sci"},{"issue":"3","key":"1006_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0014-2999(99)00191-0","volume":"372","author":"AJ Harkin","year":"1999","unstructured":"Harkin AJ, Bruce KH, Craft B, Paul IA (1999) Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test. Eur J Pharmacol 372(3):207\u2013213. doi: https:\/\/doi.org\/10.1016\/s0014-2999(99)00191-0","journal-title":"Eur J Pharmacol"},{"key":"1006_CR18","doi-asserted-by":"publisher","first-page":"20120407","DOI":"10.1098\/rstb.2012.0407","volume":"368","author":"CJ Harmer","year":"2013","unstructured":"Harmer CJ, Cowen PJ (2013) \u2018It\u2019s the way that you look at it\u2019\u2014a cognitive neuropsychological account of SSRI action in depression. Phil Trans R Soc B: Biol Sci 368:20120407. doi: https:\/\/doi.org\/10.1098\/rstb.2012.0407","journal-title":"Phil Trans R Soc B: Biol Sci"},{"issue":"1","key":"1006_CR19","first-page":"483","volume":"82","author":"SM Hazzaa","year":"2014","unstructured":"Hazzaa SM, Ewida SF, Elbatsh M (2014) Influence of the Phosphodiesterase type 5 inhibitor, sildenafil, on some behavioral and central biochemical changes on chronic restraint stress in rats. Med J Cairo Univ 82(1):483\u2013493","journal-title":"Med J Cairo Univ"},{"issue":"2","key":"1006_CR20","first-page":"157","volume":"46","author":"D Hoyer","year":"1994","unstructured":"Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46(2):157\u2013203","journal-title":"Pharmacol Rev"},{"issue":"2","key":"1006_CR21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/s0006-8993(99)01599-1","volume":"835","author":"ST Kaehler","year":"1999","unstructured":"Kaehler ST, Singewald N, Sinner C, Philippu A (1999) Nitric oxide modulates the release of serotonin in the rat hypothalamus. Brain Res 835(2):346\u2013349. doi: https:\/\/doi.org\/10.1016\/s0006-8993(99)01599-1","journal-title":"Brain Res"},{"key":"1006_CR22","doi-asserted-by":"publisher","first-page":"108717","DOI":"10.1016\/j.biopha.2019.108717","volume":"112","author":"F Khakpai","year":"2019","unstructured":"Khakpai F, Ebrahimi-Ghiri M, Alijanpour S, Zarrindast MR (2019) Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system. Biomed Pharmacother 112:108717. doi: https:\/\/doi.org\/10.1016\/j.biopha.2019.108717","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1006_CR23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuint.2011.12.005","volume":"60","author":"JP Kiss","year":"2012","unstructured":"Kiss JP, Szasz BK, Fodor L, Mike A, Lenkey N, Kurk\u00f3 D, Nagy J, Vizi ES (2012) GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine. Neurochem Int 60(2):170\u2013176. doi: https:\/\/doi.org\/10.1016\/j.neuint.2011.12.005","journal-title":"Neurochem Int"},{"key":"1006_CR24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00228-009-0650-7","volume":"65","author":"E Kucukibrahimoglu","year":"2009","unstructured":"Kucukibrahimoglu E, Saygin MZ, Caliskan M, Kaplan OK, Unsal C, Goren MZ (2009) The change in plasma GABA, glutamine, and glutamate levels in fluoxetine-or S-citalopram-treated female patients with major depression. Eur J Clin Pharmacol 65:571\u2013577. doi: https:\/\/doi.org\/10.1007\/s00228-009-0650-7","journal-title":"Eur J Clin Pharmacol"},{"key":"1006_CR25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1743-6109.2012.03000.x","volume":"10","author":"C Kyratsas","year":"2013","unstructured":"Kyratsas C, Dalla C, Anderzhanova E, Polissidis A, Kokras N, Konstantinides K, Papadopoulou-Daifoti Z (2013) Experimental evidence for sildenafil\u2019s action in the central nervous system: dopamine and serotonin changes in the medial preoptic area and nucleus accumbens during sexual arousal. J Sex Med 10:719\u2013729. https:\/\/doi.org\/10.1111\/j.1743-6109.2012.03000.x","journal-title":"J Sex Med"},{"key":"1006_CR26","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0006-8993(92)91517-I","volume":"597","author":"HS Lustig","year":"1992","unstructured":"Lustig HS, Ahern KVB, Greenberg DA (1992) Antiparkinsonian drugs and in vitro excitotoxicity. Brain Res 597:148\u2013150","journal-title":"Brain Res"},{"issue":"10","key":"1006_CR27","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.2165\/11633130-000000000-00000","volume":"72","author":"DC Mathews","year":"2012","unstructured":"Mathews DC, Henter ID, Zarate CA (2012) Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date. Drugs 72(10):1313\u20131333. doi: https:\/\/doi.org\/10.2165\/11633130-000000000-00000","journal-title":"Drugs"},{"issue":"6","key":"1006_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.neuint.2009.04.005","volume":"55","author":"A Mayer","year":"2009","unstructured":"Mayer A, Szasz BK, Kiss JP (2009) Inhibitory effect of antidepressants on the NMDA-evoked [(3)H] noradrenaline release from rat hippocampal slices. Neurochem Int 55(6):383\u2013388. doi: https:\/\/doi.org\/10.1016\/j.neuint.2009.04.005","journal-title":"Neurochem Int"},{"key":"1006_CR29","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.pnpbp.2006.03.036","volume":"30","author":"H Mitani","year":"2006","unstructured":"Mitani H, Shirayama Y, Yamada T, Maeda K, Ashby CR Jr, Kawahara R (2006) Correlation between plasma levels of glutamate, alanine, and serine with severity of depression. Prog Neuropsychopharmacol Biol Psychiatry 30:1155\u20131158. doi: https:\/\/doi.org\/10.1016\/j.pnpbp.2006.03.036","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"1006_CR30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF03033190","volume":"3","author":"C Montoliu","year":"2001","unstructured":"Montoliu C, Llansola M, Monfort P, Corbalan R, Fernandez-Marticorena I, Hernandez-Viadel ML, Felipo V (2001) Role of nitric oxide and cyclic GMP in glutamate-induced neuronal death. Neurotoxic Res 3(2):179\u2013188. doi: https:\/\/doi.org\/10.1007\/BF03033190","journal-title":"Neurotoxic Res"},{"issue":"5","key":"1006_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/biom9050191","volume":"9","author":"T Nakano","year":"2019","unstructured":"Nakano T, Hasegawa T, Suzuki D, Motomura E, Okada M (2019) Amantadine Combines Astroglial System Xc- Activation with Glutamate\/NMDA Receptor Inhibition. Biomolecules 9(5):191. doi: https:\/\/doi.org\/10.3390\/biom9050191","journal-title":"Biomolecules"},{"issue":"1","key":"1006_CR32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.brainres.2006.02.107","volume":"1086","author":"CO Okere","year":"2006","unstructured":"Okere CO, Waterhouse BD (2006) Activity-dependent heterogeneous populations of nitric oxide synthase neurons in the rat dorsal raphe nucleus (2006). Brain Res 1086(1):117\u2013132. doi: https:\/\/doi.org\/10.1016\/j.brainres.2006.02.107","journal-title":"Brain Res"},{"issue":"1","key":"1006_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pbb.2003.09.015","volume":"77","author":"CM Padovan","year":"2004","unstructured":"Padovan CM, Guimar\u00e3es FS (2004) Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats. Pharmacol Biochem Behav 77(1):15\u201319. doi: https:\/\/doi.org\/10.1016\/j.pbb.2003.09.015","journal-title":"Pharmacol Biochem Behav"},{"issue":"9","key":"1006_CR34","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1111\/j.1460-9568.2012.08243.x","volume":"36","author":"MA Paquette","year":"2012","unstructured":"Paquette MA, Martinez AA, Macheda T, Meshul CK, Johnson SW, Berger SP, Giuffrida A (2012) Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson\u2019s disease: role of NMDA vs. 5-HT1A receptors. Eur J Neurosci 36(9):3224\u20133234. doi: https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08243.x","journal-title":"Eur J Neurosci"},{"key":"1006_CR35","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre ML (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730. doi: https:\/\/doi.org\/10.1038\/266730a0","journal-title":"Nature"},{"issue":"13","key":"1006_CR36","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1523\/JNEUROSCI.4799-06.2007","volume":"27","author":"GA Rameau","year":"2007","unstructured":"Rameau GA, Tukey DS, Garcin-Hosfield ED, Titcombe RF, Misra C, Khatri L, Getzoff ED, Ziff EB (2007) Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death. J Neurosci 27(13):3445\u20133455. doi: https:\/\/doi.org\/10.1523\/JNEUROSCI.4799-06.2007","journal-title":"J Neurosci"},{"key":"1006_CR37","doi-asserted-by":"publisher","unstructured":"Roni MA, Rahman S (2015) Effects of lobeline and reboxetine, fluoxetine, or bupropion combination on depression-like behaviors in mice. Pharmacol Biochem Behav 139(Pt A) 1\u20136. doi: https:\/\/doi.org\/10.1016\/j.pbb.2015.10.006","DOI":"10.1016\/j.pbb.2015.10.006"},{"key":"1006_CR38","first-page":"36","volume":"13","author":"RC Rosen","year":"2002","unstructured":"Rosen RC, McKenna KE (2002) PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes. Annu Rev Sex Res 13:36\u201388","journal-title":"Annu Rev Sex Res"},{"issue":"9","key":"1006_CR39","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.biopsych.2010.09.011","volume":"68","author":"G Salvadore","year":"2010","unstructured":"Salvadore G, Zarate CA (2010) Jr Magnetic resonance spectroscopy studies of the glutamatergic system in mood disorders: a pathway to diagnosis, novel therapeutics, and personalized medicine? Biol Psychiatry 68(9):780\u2013782. doi: https:\/\/doi.org\/10.1016\/j.biopsych.2010.09.011","journal-title":"Biol Psychiatry"},{"issue":"9","key":"1006_CR40","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/mp.2013.130","volume":"19","author":"G Sanacora","year":"2014","unstructured":"Sanacora G, Smith MA, Pathak S, Su HL, Boeijinga PH, McCarthy DJ, Quirk MC (2014) Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry 19(9):978\u2013985. doi: https:\/\/doi.org\/10.1038\/mp.2013.130","journal-title":"Mol Psychiatry"},{"issue":"1","key":"1006_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","volume":"62","author":"G Sanacora","year":"2012","unstructured":"Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacol 62(1):63\u201377. doi: https:\/\/doi.org\/10.1016\/j.neuropharm.2011.07.036","journal-title":"Neuropharmacol"},{"key":"1006_CR42","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1016\/0006-2952(74)90235-4","volume":"23","author":"M Schlumpf","year":"1974","unstructured":"Schlumpf M, Lichtensteiger W, Langemann H, Waser PG, Hefti F (1974) A fluorometric micro method for the simultaneous determination of serotonin, noradrenaline, and dopamine in milligram amounts of brain tissue. Biochem Pharmacol 23:2437\u20132446. doi: https:\/\/doi.org\/10.1016\/0006-2952(74)90235-4","journal-title":"Biochem Pharmacol"},{"key":"1006_CR43","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.2174\/13816128113199990293","volume":"19","author":"G Serafini","year":"2013","unstructured":"Serafini G, Pompili M, Innamorati M, Dwivedi Y, Brahmachari G, Girardi P (2013) Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression. Curr Pharm Des 19:1898\u20131922. doi: https:\/\/doi.org\/10.2174\/13816128113199990293","journal-title":"Curr Pharm Des"},{"issue":"3","key":"1006_CR44","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/1947-2714.153921","volume":"7","author":"V Shinde","year":"2015","unstructured":"Shinde V, Yegnanarayan R, Shah P, Gupta A, Pophale P (2015) Antidepressant-like activity of flunarizine in modified tail suspension test in rats. N Am J Med Sci 7(3):100\u2013103. doi: https:\/\/doi.org\/10.4103\/1947-2714.153921","journal-title":"N Am J Med Sci"},{"key":"1006_CR45","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.pbb.2012.08.012","volume":"103","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012a) Influence of sildenafil on the antidepressant activity of bupropion and venlafaxine in the forced swim test in mice. Pharmacol Biochem Behav 103:273\u2013278. doi: https:\/\/doi.org\/10.1016\/j.pbb.2012.08.012","journal-title":"Pharmacol Biochem Behav"},{"key":"1006_CR46","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00702-011-0756-9","volume":"119","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012b) Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice. J Neural Transm 119:645\u2013652. doi: https:\/\/doi.org\/10.1007\/s00702-011-0756-9","journal-title":"J Neural Transm"},{"key":"1006_CR47","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/s1734-1140(12)70922-2","volume":"64","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012c) Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice. Pharmacol Rep 64:1259\u20131266. doi: https:\/\/doi.org\/10.1016\/s1734-1140(12)70922-2","journal-title":"Pharmacol Rep"},{"key":"1006_CR48","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacol 85:367\u2013370. doi: https:\/\/doi.org\/10.1007\/BF00428203","journal-title":"Psychopharmacol"},{"key":"1006_CR49","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.biopsych.2007.04.014","volume":"62","author":"BK Szasz","year":"2007","unstructured":"Szasz BK (2007) Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system. Biol Psychiatry 62:1303\u20131309. doi: https:\/\/doi.org\/10.1016\/j.biopsych.2007.04.014","journal-title":"Biol Psychiatry"},{"key":"1006_CR50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/s0361-9230(00)00450-0","volume":"54","author":"P Tagliaferro","year":"2001","unstructured":"Tagliaferro P (2001) Increased nitric oxide synthase activity in a model of serotonin depletion. Brain Res Bull 54:199\u2013205. doi: https:\/\/doi.org\/10.1016\/s0361-9230(00)00450-0","journal-title":"Brain Res Bull"},{"key":"1006_CR51","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","volume":"163","author":"MH Trivedi","year":"2006","unstructured":"Trivedi MH, Wisniewski SRRA, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramanian GK, Fava M (2006) STAR* D Study Team: Evaluation of outcomes with citalopram for depression using measurement-based care in STAR-D: implications for clinical practice. Am J Psychiatr 163:28\u201340. doi: https:\/\/doi.org\/10.1176\/appi.ajp.163.1.28","journal-title":"Am J Psychiatr"},{"key":"1006_CR52","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0166-4328(02)00312-1","volume":"140","author":"V Volke","year":"2003","unstructured":"Volke V, Wegener G, Bourin M, Vasar E (2003) Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res 140:141\u2013147. doi: https:\/\/doi.org\/10.1016\/s0166-4328(02)00312-1","journal-title":"Behav Brain Res"},{"key":"1006_CR53","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.brainresbull.2019.06.008","volume":"150","author":"V Walia","year":"2019","unstructured":"Walia V, Garg C, Garg M (2019) Lithium potentiated, pyridoxine abolished, and fluoxetine attenuated the anxiolytic effect of diazepam in mice. Brain Res Bull 150:343\u2013353. doi: https:\/\/doi.org\/10.1016\/j.brainresbull.2019.06.008","journal-title":"Brain Res Bull"},{"key":"1006_CR54","doi-asserted-by":"publisher","first-page":"112432","DOI":"10.1016\/j.bbr.2019.112432","volume":"380","author":"V Walia","year":"2020","unstructured":"Walia V, Garg C, Garg M (2020) Amantadine exerts anxiolytic like effect in mice: Evidence for the involvement of nitrergic and GABAergic signaling pathways. Behav Brain Res 380:112432. doi: https:\/\/doi.org\/10.1016\/j.bbr.2019.112432","journal-title":"Behav Brain Res"},{"key":"1006_CR55","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/BF01250322","volume":"44","author":"W Wesemann","year":"1979","unstructured":"Wesemann W, Dette-Wildenhahn G, Fellellner H (1979) In vitro studies on the possible effects of L-aminoadamantanes of the serotonergic system in M. Parkinson J Neural Transrn 44:263\u2013285. doi: https:\/\/doi.org\/10.1007\/BF01250322","journal-title":"Parkinson J Neural Transrn"},{"key":"1006_CR56","doi-asserted-by":"publisher","unstructured":"Whitton PS, Biggs CS, Pearce BR, Fowler LJ (1992a) MK-801 increases extracellular 5-hydroxytryptamine in rat hippocampus and striatum in vivo J. Neurochem 58:1573\u20131575. doi: https:\/\/doi.org\/10.1111\/j.1471-4159. 1992.tb11381.x","DOI":"10.1111\/j.1471-4159"},{"key":"1006_CR57","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3940(92)90607-9","volume":"142","author":"PS Whitton","year":"1992","unstructured":"Whitton PS, Biggs CS, Pearce BR, Fowler LJ (1992b) Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis. Neurosci Lett 142:5\u20138. doi: https:\/\/doi.org\/10.1016\/0304-3940(92)90607-9","journal-title":"Neurosci Lett"},{"key":"1006_CR58","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0304-3940(94)90395-6","volume":"169","author":"PS Whitton","year":"1994","unstructured":"Whitton PS, Richards DA, Biggs CS, Fowler LJ (1994) N-methyl-D-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo. Neurosci Lett 169:215\u2013218. doi: https:\/\/doi.org\/10.1016\/0304-3940(94)90395-6","journal-title":"Neurosci Lett"},{"key":"1006_CR59","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.conb.2015.11.001","volume":"36","author":"NR Williams","year":"2016","unstructured":"Williams NR, Schatzberg AF (2016) NMDA antagonist treatment of depression. Curr Opin Neurobiol 36:112\u2013117. doi: https:\/\/doi.org\/10.1016\/j.conb.2015.11.001","journal-title":"Curr Opin Neurobiol"},{"issue":"7","key":"1006_CR60","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1523\/JNeurosci.5880-09.2010","volume":"30","author":"J Zhang","year":"2010","unstructured":"Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Hu Y, Zhou QG, Wu DL, Zhu LJ, Zhu DY (2010) Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. J Neurosci 30(7):2433\u20132441. doi: https:\/\/doi.org\/10.1523\/JNeurosci.5880-09.2010","journal-title":"J Neurosci"},{"issue":"6","key":"1006_CR61","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.niox.2009.03.001","volume":"65","author":"CB Zhu","year":"2004","unstructured":"Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol Pharmacol 65(6):1462\u20131474. doi: https:\/\/doi.org\/10.1016\/j.niox.2009.03.001","journal-title":"Mol Pharmacol"},{"issue":"2","key":"1006_CR62","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.pbb.2012.09.011","volume":"103","author":"AD Zomkowski","year":"2012","unstructured":"Zomkowski AD, Engel D, Cunha MP, Gabilan NH, Rodrigues AL (2012) The role of the NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test. Pharmacol Biochem Behav 103(2):408\u2013417. doi: https:\/\/doi.org\/10.1016\/j.pbb.2012.09.011","journal-title":"Pharmacol Biochem Behav"},{"key":"1006_CR63","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.euroneuro.2010.07.011","volume":"20","author":"AD Zomkowski","year":"2010","unstructured":"Zomkowski AD, Engel D, Gabilan NH, Rodrigues AL (2010) Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. Eur Neuropsychopharmacol 20:793\u2013801. doi: https:\/\/doi.org\/10.1016\/j.euroneuro.2010.07.011","journal-title":"Eur Neuropsychopharmacol"},{"key":"1006_CR64","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fpsyt.2015.00172","volume":"6","author":"CF Zorumski","year":"2015","unstructured":"Zorumski CF, Nagele P, Mennerick S, Conway CR (2015) Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy. Front Psychiatry 6:172. doi: https:\/\/doi.org\/10.3389\/fpsyt.2015.00172","journal-title":"Front Psychiatry"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01006-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-01006-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01006-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T17:33:25Z","timestamp":1657820005000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-01006-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1006"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-01006-4","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]},"assertion":[{"value":"9 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\/Competing interests"}},{"value":"The study was approved by the IAEC, SGT University, Gurugram.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable for this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors agreed for the publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}