{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:41:04Z","timestamp":1792806064373,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11011-022-01017-1","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T07:02:58Z","timestamp":1655276578000},"page":"1803-1813","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["miR-25-3p ameliorates SAE by targeting the TLR4\/NLRP3 axis"],"prefix":"10.1007","volume":"37","author":[{"given":"Xiao-Yan","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-5882","authenticated-orcid":false,"given":"Qiao-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"issue":"16","key":"1017_CR1","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1007\/s00018-015-1922-2","volume":"72","author":"F Afonso-Grunz","year":"2015","unstructured":"Afonso-Grunz F, Muller S (2015) Principles of miRNA-mRNA interactions: beyond sequence complementarity. Cell Mol Life Sci 72(16):3127\u20133141. https:\/\/doi.org\/10.1007\/s00018-015-1922-2","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"1017_CR2","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281\u2013297. https:\/\/doi.org\/10.1016\/s0092-8674(04)00045-5","journal-title":"Cell"},{"key":"1017_CR3","doi-asserted-by":"publisher","unstructured":"Benz F, Roy S, Trautwein C, Roderburg C, Luedde T (2016) Circulating MicroRNAs as biomarkers for Sepsis. Int J Mol Sci 17(1). https:\/\/doi.org\/10.3390\/ijms17010078","DOI":"10.3390\/ijms17010078"},{"key":"1017_CR4","doi-asserted-by":"publisher","unstructured":"Berg D, Gerlach H (2018) Recent advances in understanding and managing sepsis. F1000Res 7. https:\/\/doi.org\/10.12688\/f1000research.15758.1","DOI":"10.12688\/f1000research.15758.1"},{"issue":"21","key":"1017_CR5","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.21037\/atm-20-7024","volume":"8","author":"SL Chen","year":"2020","unstructured":"Chen SL, Cai GX, Ding HG, Liu XQ, Wang ZH, Jing YW, Han YL, Jiang WQ, Wen MY (2020) JAK\/STAT signaling pathway-mediated microRNA-181b promoted blood-brain barrier impairment by targeting sphingosine-1-phosphate receptor 1 in septic rats. Ann Transl Med 8(21):1458. https:\/\/doi.org\/10.21037\/atm-20-7024","journal-title":"Ann Transl Med"},{"key":"1017_CR6","doi-asserted-by":"publisher","unstructured":"Chung HY, Wickel J, Brunkhorst FM, Geis C (2020) Sepsis-associated encephalopathy: from delirium to dementia? J Clin Med 9(3). https:\/\/doi.org\/10.3390\/jcm9030703","DOI":"10.3390\/jcm9030703"},{"issue":"10","key":"1017_CR7","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","volume":"8","author":"TE Gofton","year":"2012","unstructured":"Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8(10):557\u2013566. https:\/\/doi.org\/10.1038\/nrneurol.2012.183","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"1017_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.201709069","volume":"217","author":"DV Hansen","year":"2018","unstructured":"Hansen DV, Hanson JE, Sheng M (2018) Microglia in Alzheimer's disease. J Cell Biol 217(2):459\u2013472. https:\/\/doi.org\/10.1083\/jcb.201709069","journal-title":"J Cell Biol"},{"issue":"7434","key":"1017_CR9","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"key":"1017_CR10","doi-asserted-by":"publisher","first-page":"107388","DOI":"10.1016\/j.intimp.2021.107388","volume":"93","author":"S Hu","year":"2021","unstructured":"Hu S, Pi Q, Luo M, Cheng Z, Liang X, Luo S, Xia Y (2021) Contribution of the NLRP3\/IL-1beta axis to impaired vasodilation in sepsis through facilitation of eNOS proteolysis and the protective role of melatonin. Int Immunopharmacol 93:107388. https:\/\/doi.org\/10.1016\/j.intimp.2021.107388","journal-title":"Int Immunopharmacol"},{"key":"1017_CR11","doi-asserted-by":"publisher","unstructured":"Huang M, Cai S, Su J (2019) The pathogenesis of Sepsis and potential therapeutic targets. Int J Mol Sci 20(21). https:\/\/doi.org\/10.3390\/ijms20215376","DOI":"10.3390\/ijms20215376"},{"key":"1017_CR12","doi-asserted-by":"publisher","unstructured":"Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F (2017) TLR4 signaling pathway modulators as potential therapeutics in inflammation and Sepsis. Vaccines (Basel) 5(4). https:\/\/doi.org\/10.3390\/vaccines5040034","DOI":"10.3390\/vaccines5040034"},{"key":"1017_CR13","doi-asserted-by":"publisher","unstructured":"Lin Q, Li S, Jiang N, Jin H, Shao X, Zhu X, Wu J, Zhang M, Zhang Z, Shen J, Zhou W, Gu L, Lu R, Ni Z (2020) Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy 1-16. https:\/\/doi.org\/10.1080\/15548627.2020.1848971","DOI":"10.1080\/15548627.2020.1848971"},{"key":"1017_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","volume":"157","author":"Y Ma","year":"2017","unstructured":"Ma Y, Wang J, Wang Y, Yang GY (2017) The biphasic function of microglia in ischemic stroke. Prog Neurobiol 157:247\u2013272. https:\/\/doi.org\/10.1016\/j.pneurobio.2016.01.005","journal-title":"Prog Neurobiol"},{"issue":"2","key":"1017_CR15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s13311-020-00862-1","volume":"17","author":"A Mazeraud","year":"2020","unstructured":"Mazeraud A, Righy C, Bouchereau E, Benghanem S, Bozza FA, Sharshar T (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17(2):392\u2013403. https:\/\/doi.org\/10.1007\/s13311-020-00862-1","journal-title":"Neurotherapeutics"},{"issue":"1","key":"1017_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jss.2012.07.063","volume":"182","author":"CC Moore","year":"2013","unstructured":"Moore CC, McKillop IH, Huynh T (2013) MicroRNA expression following activated protein C treatment during septic shock. J Surg Res 182(1):116\u2013126. https:\/\/doi.org\/10.1016\/j.jss.2012.07.063","journal-title":"J Surg Res"},{"issue":"4","key":"1017_CR17","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol 173(4):649\u2013665. https:\/\/doi.org\/10.1111\/bph.13139","journal-title":"Br J Pharmacol"},{"issue":"9","key":"1017_CR18","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.1007\/s12035-021-02445-3","volume":"58","author":"R Osca-Verdegal","year":"2021","unstructured":"Osca-Verdegal R, Beltr\u00e1n-Garc\u00eda J, Pallard\u00f3 FV, Garc\u00eda-Gim\u00e9nez JL (2021) Role of microRNAs as biomarkers in Sepsis-associated encephalopathy. Mol Neurobiol 58(9):4682\u20134693. https:\/\/doi.org\/10.1007\/s12035-021-02445-3","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1017_CR19","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1159\/000490866","volume":"47","author":"Q Su","year":"2018","unstructured":"Su Q, Li L, Sun Y, Yang H, Ye Z, Zhao J (2018) Effects of the TLR4\/Myd88\/NF-kappaB signaling pathway on NLRP3 Inflammasome in coronary microembolization-induced myocardial injury. Cell Physiol Biochem 47(4):1497\u20131508. https:\/\/doi.org\/10.1159\/000490866","journal-title":"Cell Physiol Biochem"},{"key":"1017_CR20","doi-asserted-by":"publisher","first-page":"1045657","DOI":"10.1155\/2016\/1045657","volume":"2016","author":"DM Sui","year":"2016","unstructured":"Sui DM, Xie Q, Yi WJ, Gupta S, Yu XY, Li JB, Wang J, Wang JF, Deng XM (2016) Resveratrol protects against Sepsis-associated encephalopathy and inhibits the NLRP3\/IL-1beta Axis in microglia. Mediat Inflamm 2016:1045657. https:\/\/doi.org\/10.1155\/2016\/1045657","journal-title":"Mediat Inflamm"},{"issue":"6","key":"1017_CR21","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.3892\/etm.2018.6032","volume":"15","author":"X Sun","year":"2018","unstructured":"Sun X, Sun J, Shao X, Feng J, Yan J, Qin Y (2018) Inhibition of microRNA-155 modulates endotoxin tolerance by upregulating suppressor of cytokine signaling 1 in microglia. Exp Ther Med 15(6):4709\u20134716. https:\/\/doi.org\/10.3892\/etm.2018.6032","journal-title":"Exp Ther Med"},{"issue":"1","key":"1017_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000480340","volume":"43","author":"X Tan","year":"2017","unstructured":"Tan X, Zheng X, Huang Z, Lin J, Xie C, Lin Y (2017) Involvement of S100A8\/A9-TLR4-NLRP3 Inflammasome pathway in contrast-induced acute kidney injury. Cell Physiol Biochem 43(1):209\u2013222. https:\/\/doi.org\/10.1159\/000480340","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"1017_CR23","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Y Tang","year":"2016","unstructured":"Tang Y, Le W (2016) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181\u20131194. https:\/\/doi.org\/10.1007\/s12035-014-9070-5","journal-title":"Mol Neurobiol"},{"key":"1017_CR24","doi-asserted-by":"publisher","first-page":"1784014","DOI":"10.1155\/2016\/1784014","volume":"2016","author":"TM Venancio","year":"2016","unstructured":"Venancio TM, Machado RM, Castoldi A, Amano MT, Nunes VS, Quintao EC, Camara NO, Soriano FG, Cazita PM (2016) CETP lowers TLR4 expression which attenuates the inflammatory response induced by LPS and Polymicrobial Sepsis. Mediat Inflamm 2016:1784014. https:\/\/doi.org\/10.1155\/2016\/1784014","journal-title":"Mediat Inflamm"},{"issue":"3","key":"1017_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/SHK.0000000000001473","volume":"54","author":"P Visitchanakun","year":"2020","unstructured":"Visitchanakun P, Tangtanatakul P, Trithiphen O, Soonthornchai W, Wongphoom J, Tachaboon S, Srisawat N, Leelahavanichkul A (2020) Plasma miR-370-3P as a biomarker of Sepsis-associated encephalopathy, the transcriptomic profiling analysis of Microrna-arrays from mouse brains. Shock 54(3):347\u2013357. https:\/\/doi.org\/10.1097\/SHK.0000000000001473","journal-title":"Shock"},{"issue":"6","key":"1017_CR26","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3892\/etm.2021.10895","volume":"22","author":"J Wen","year":"2021","unstructured":"Wen J, Liu Y, Zhan Z, Chen S, Hu B, Ge J, Xie Q (2021) Comprehensive analysis of mRNAs, lncRNAs and circRNAs in the early phase of microglial activation. Exp Ther Med 22(6):1460. https:\/\/doi.org\/10.3892\/etm.2021.10895","journal-title":"Exp Ther Med"},{"key":"1017_CR27","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev-physiol-022516-034406","volume":"79","author":"SA Wolf","year":"2017","unstructured":"Wolf SA, Boddeke HW, Kettenmann H (2017) Microglia in physiology and disease. Annu Rev Physiol 79:619\u2013643. https:\/\/doi.org\/10.1146\/annurev-physiol-022516-034406","journal-title":"Annu Rev Physiol"},{"key":"1017_CR28","doi-asserted-by":"publisher","unstructured":"Yao Y, Sun F, Lei M (2018) miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN. Biosci Rep 38(2). https:\/\/doi.org\/10.1042\/BSR20171511","DOI":"10.1042\/BSR20171511"},{"key":"1017_CR29","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.3389\/fimmu.2019.02205","volume":"10","author":"Y Yao","year":"2019","unstructured":"Yao Y, Sun W, Sun Q, Jing B, Liu S, Liu X, Shen G, Chen R, Wang H (2019) Platelet-derived Exosomal MicroRNA-25-3p inhibits coronary vascular endothelial cell inflammation through Adam10 via the NF-kappaB signaling pathway in ApoE(\u2212\/\u2212) mice. Front Immunol 10:2205. https:\/\/doi.org\/10.3389\/fimmu.2019.02205","journal-title":"Front Immunol"},{"issue":"1","key":"1017_CR30","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12974-020-01970-7","volume":"17","author":"J Yin","year":"2020","unstructured":"Yin J, Shen Y, Si Y, Zhang Y, Du J, Hu X, Cai M, Bao H, Xing Y (2020) Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy. J Neuroinflammation 17(1):320. https:\/\/doi.org\/10.1186\/s12974-020-01970-7","journal-title":"J Neuroinflammation"},{"key":"1017_CR31","doi-asserted-by":"publisher","first-page":"105731","DOI":"10.1016\/j.intimp.2019.105731","volume":"75","author":"CC Zhang","year":"2019","unstructured":"Zhang CC, Niu F (2019) LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the let-7a\/TLR4 axis. Int Immunopharmacol 75:105731. https:\/\/doi.org\/10.1016\/j.intimp.2019.105731","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"1017_CR32","doi-asserted-by":"publisher","first-page":"5027","DOI":"10.3892\/ol.2018.9308","volume":"16","author":"C Zhu","year":"2018","unstructured":"Zhu C, Chen T, Liu B (2018) Inhibitory effects of miR-25 targeting HMGB1 on macrophage secretion of inflammatory cytokines in sepsis. Oncol Lett 16(4):5027\u20135033. https:\/\/doi.org\/10.3892\/ol.2018.9308","journal-title":"Oncol Lett"},{"key":"1017_CR33","doi-asserted-by":"publisher","first-page":"106287","DOI":"10.1016\/j.intimp.2020.106287","volume":"81","author":"X Zhuang","year":"2020","unstructured":"Zhuang X, Yu Y, Jiang Y, Zhao S, Wang Y, Su L, Xie K, Yu Y, Lu Y, Lv G (2020) Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. Int Immunopharmacol 81:106287. https:\/\/doi.org\/10.1016\/j.intimp.2020.106287","journal-title":"Int Immunopharmacol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01017-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-01017-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01017-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:47:40Z","timestamp":1744170460000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-01017-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1017"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-01017-1","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"assertion":[{"value":"9 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All in vivo experiments were performed in accordance with National Institutes of Health guide for the care and use of laboratory animals, following a protocol approved by the Ethics Committees of the First Affiliated Hospital of University of South China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}