{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:46:37Z","timestamp":1790635597851,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s11011-022-01104-3","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T04:02:37Z","timestamp":1667016157000},"page":"349-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-8328","authenticated-orcid":false,"given":"Adeola O.","family":"Adedara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titilayomi A.","family":"Otenaike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodeji A.","family":"Olabiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac A.","family":"Adedara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos O.","family":"Abolaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"issue":"2","key":"1104_CR1","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.bbrc.2018.06.114","volume":"503","author":"AO Abolaji","year":"2018","unstructured":"Abolaji AO, Adedara AO, Adie MA, Vicente-Crespo M, Farombi EO (2018) Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced oxidative damage and behavioural deficits in Drosophila melanogaster Biochem Biophys Res Commun 503(2):1042\u20131048","journal-title":"Biochem Biophys Res Commun"},{"key":"1104_CR2","first-page":"33","volume":"1","author":"AO Abolaji","year":"2013","unstructured":"Abolaji AO, Kamdem JP, Farombi EO, Rocha JBT (2013) Drosophila melanogaster as a promising model organism in toxicological studies. Arch Bas App Med 1:33\u201338","journal-title":"Arch Bas App Med"},{"key":"1104_CR3","doi-asserted-by":"crossref","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","DOI":"10.1016\/S0076-6879(84)05016-3"},{"issue":"1","key":"1104_CR4","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1038\/s41598-022-08409-4","volume":"12","author":"TC Akinade","year":"2022","unstructured":"Akinade TC, Babatunde OO, Adedara AO, Adeyemi OE, Otenaike TA, Ashaolu OP, Johnson TO, Terriente-Felix A, Whitworth AJ, Abolaji AO (2022) Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster. Sci Rep 12(1):4594. https:\/\/doi.org\/10.1038\/s41598-022-08409-4","journal-title":"Sci Rep"},{"key":"1104_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jhazmat.2018.07.050","volume":"370","author":"A Anet","year":"2019","unstructured":"Anet A, Olakkaran S, Purayil AK, Puttaswamygowda GH (2019) Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster J Hazard Mater 370:42\u201353","journal-title":"J Hazard Mater"},{"key":"1104_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2016.06.005","volume":"100","author":"PR Angelova","year":"2016","unstructured":"Angelova PR, Abramov AY (2016) Functional role of mitochondrial reactive oxygen species in physiology. Free Radic Biol Med 100:81\u201385","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"1104_CR7","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","volume":"15","author":"RP Bazinet","year":"2014","unstructured":"Bazinet RP, Lay\u00e9 S (2014) Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15(12):771\u2013785","journal-title":"Nat Rev Neurosci"},{"key":"1104_CR8","doi-asserted-by":"crossref","unstructured":"Beard JL, Connor JR (2003)\u00a0Iron status and neural functioning. Annu Rev Nutr 23(1):41\u201358","DOI":"10.1146\/annurev.nutr.23.020102.075739"},{"key":"1104_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/jnc.13425","volume":"139","author":"AA Belaidi","year":"2016","unstructured":"Belaidi AA, Bush AI (2016) Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: targets for therapeutics. J Neurochem 139:179\u2013197","journal-title":"J Neurochem"},{"issue":"2","key":"1104_CR10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1515\/reveh-2017-0025","volume":"33","author":"SR Boovarahan","year":"2018","unstructured":"Boovarahan SR, Kurian GA (2018) Mitochondrial dysfunction: A key player in the pathogenesis of cardiovascular diseases linked to air pollution. Rev Environ Health 33(2):111\u2013122","journal-title":"Rev Environ Health"},{"key":"1104_CR11","doi-asserted-by":"crossref","unstructured":"Bresgen N, Eckl PM (2015) Oxidative stress and the homeodynamics of iron metabolism. Biomolecules 5(2):808\u2013847","DOI":"10.3390\/biom5020808"},{"issue":"2","key":"1104_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/toxsci\/kfr239","volume":"124","author":"JR Cannon","year":"2011","unstructured":"Cannon JR, Greenamyre JT (2011) The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci 124(2):225\u2013250","journal-title":"Toxicol Sci"},{"key":"1104_CR13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fncel.2015.00124","volume":"9","author":"M Chin-Chan","year":"2015","unstructured":"Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B (2015) Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci 9:124","journal-title":"Front Cell Neurosci"},{"key":"1104_CR14","doi-asserted-by":"crossref","unstructured":"Chotard C, Salecker I (2007) Glial cell development and function in the Drosophila visual system. Neuron Glia Biol 3(1):17\u201325","DOI":"10.1017\/S1740925X07000592"},{"issue":"4","key":"1104_CR15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","volume":"52","author":"I Dalle-Donne","year":"2006","unstructured":"Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A (2006) Biomarkers of oxidative damage in human disease. Clin Chem 52(4):601\u2013623","journal-title":"Clin Chem"},{"key":"1104_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mad.2015.12.001","volume":"153","author":"BM Dancy","year":"2016","unstructured":"Dancy BM, Brockway N, Ramadasan-Nair R, Yang Y, Sedensky MM, Morgan PG (2016) Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction. Mech Ageing Dev 153:14\u201321","journal-title":"Mech Ageing Dev"},{"key":"1104_CR17","doi-asserted-by":"crossref","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377","DOI":"10.1016\/0003-9861(59)90090-6"},{"issue":"2","key":"1104_CR18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres V Jr, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2):88\u201395","journal-title":"Biochem Pharmacol"},{"key":"1104_CR19","doi-asserted-by":"publisher","first-page":"109431","DOI":"10.1016\/j.cbi.2021.109431","volume":"340","author":"EJ Fernandes","year":"2021","unstructured":"Fernandes EJ, Poetini MR, Barrientos MS, Bortolotto VC, Araujo SM, Musachio EAS, De Carvalho AS, Leimann FV, Gon\u00e7alves OH, Ramborger BP, Roehrs R (2021) Exposure to lutein-loaded nanoparticles attenuates Parkinson\u2019s model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators. Chem Biol Interact 340:109431","journal-title":"Chem Biol Interact"},{"key":"1104_CR20","first-page":"94","volume":"202","author":"FH Figueira","year":"2017","unstructured":"Figueira FH, de Quadros Oliveira N, de Aguiar LM, Escarrone AL, Primel EG, Barros DM, da Rosa CE (2017) Exposure to atrazine alters behaviour and disrupts the dopaminergic system in Drosophila melanogaster. Comp Biochem Physiol C: Toxicol Pharmacol 202:94\u2013102","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"issue":"1","key":"1104_CR21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15\u00a0N] nitrate in biological fluids. Anal Biochem 126(1):131\u2013138","journal-title":"Anal Biochem"},{"key":"1104_CR22","doi-asserted-by":"crossref","unstructured":"Habig WH, Jakoby WB (1981)\u00a0Assays for differentiation of glutathione S-Transferases. Methods Enzymol 77:398\u2013405. Academic","DOI":"10.1016\/S0076-6879(81)77053-8"},{"key":"1104_CR23","first-page":"1147","volume":"5","author":"B Halliwell","year":"2017","unstructured":"Halliwell B (2017) Biochemistry of oxidative stress. Biochem Soc Trans 5:1147\u20131150","journal-title":"Biochem Soc Trans"},{"key":"1104_CR24","doi-asserted-by":"publisher","first-page":"174413","DOI":"10.1016\/j.ejphar.2021.174413","volume":"909","author":"Y Han","year":"2021","unstructured":"Han Y, Wang T, Li C, Wang Z, Zhao Y, He J, Fu L, Han B (2021) Ginsenoside Rg3 exerts a neuroprotective effect in rotenone-induced Parkinson\u2019s disease mice via its anti-oxidative properties. Eur J Pharmacol 909:174413","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1104_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep45465","volume":"7","author":"S Heinz","year":"2017","unstructured":"Heinz S, Freyberger A, Lawrenz B, Schladt L, Schmuck G, Ellinger-Ziegelbauer H (2017) Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of pharmacological and safety evaluation. Sci Rep 7(1):1\u201313","journal-title":"Sci Rep"},{"issue":"2","key":"1104_CR26","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.bbrc.2020.04.068","volume":"527","author":"SL Johnson","year":"2020","unstructured":"Johnson SL, Iannucci J, Seeram NP, Grammas P (2020) Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson\u2019s disease. Biochem Biophys Res Commun 527(2):532\u2013538","journal-title":"Biochem Biophys Res Commun"},{"key":"1104_CR27","doi-asserted-by":"crossref","unstructured":"Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR (1974) Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11(3):151\u2013169","DOI":"10.1159\/000136485"},{"key":"1104_CR28","doi-asserted-by":"publisher","first-page":"101957","DOI":"10.1016\/j.jchemneu.2021.101957","volume":"114","author":"DN Jones","year":"2021","unstructured":"Jones DN, Raghanti MA (2021) The role of monoamine oxidase enzymes in the pathophysiology of neurological disorders. J Chem Neuroanat 114:101957","journal-title":"J Chem Neuroanat"},{"key":"1104_CR29","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","volume":"21","author":"L Kaplan","year":"2021","unstructured":"Kaplan L, Chow BW, Gu C (2021) Neuronal regulation of the blood\u2013brain barrier and neurovascular coupling. Nat Rev Neurosci 21:416\u2013432","journal-title":"Nat Rev Neurosci"},{"key":"1104_CR30","doi-asserted-by":"publisher","first-page":"133664","DOI":"10.1016\/j.neulet.2018.06.033","volume":"726","author":"J Kealy","year":"2020","unstructured":"Kealy J, Greene C, Campbell M (2020) Blood-brain barrier regulation in psychiatric disorders. Neurosci Lett 726:133664","journal-title":"Neurosci Lett"},{"key":"1104_CR31","doi-asserted-by":"crossref","unstructured":"Kim J, Wessling-Resnick M (2014) Iron and mechanisms of emotional behavior. J Nutr Biochem 25(11):1101\u20131107","DOI":"10.1016\/j.jnutbio.2014.07.003"},{"key":"1104_CR32","doi-asserted-by":"publisher","first-page":"111860","DOI":"10.1016\/j.fct.2020.111860","volume":"146","author":"PP Kumar","year":"2020","unstructured":"Kumar PP, Prashanth KH (2020) Diet with Low Molecular Weight Chitosan exerts neuromodulation in Rotenone induced Drosophila model of Parkinson\u2019s disease. Food Chem Toxicol 146:111860","journal-title":"Food Chem Toxicol"},{"key":"1104_CR33","doi-asserted-by":"crossref","unstructured":"Li J, Li W, Jiang ZG, Ghanbari HA (2013) Oxidative stress and neurodegenerative disorders. Int J Mol Sci 14(12):24438\u201324475","DOI":"10.3390\/ijms141224438"},{"key":"1104_CR34","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"1104_CR35","doi-asserted-by":"publisher","first-page":"111232","DOI":"10.1016\/j.ecoenv.2020.111232","volume":"206","author":"GE Macedo","year":"2020","unstructured":"Macedo GE, de Brum Vieira P, Rodrigues NR, Gomes KK, Martins IK, Franco JL, Posser T (2020) Fungal compound 1-octen-3-ol induces mitochondrial morphological alterations and respiration dysfunctions in Drosophila melanogaster. Ecotoxicol Environ Saf 206:111232","journal-title":"Ecotoxicol Environ Saf"},{"key":"1104_CR36","doi-asserted-by":"crossref","unstructured":"McEwen CM Jr (1971) Monoamine oxidase [rabbit serum]. Methods in enzymology, vol 17. Academic,\u00a0Cambridge, pp 686\u2013692","DOI":"10.1016\/0076-6879(71)17119-4"},{"key":"1104_CR37","doi-asserted-by":"crossref","unstructured":"Ohkawa H, Ohishi N, Yagi K (1978) Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 19(8):1053\u20131057","DOI":"10.1016\/S0022-2275(20)40690-X"},{"issue":"2","key":"1104_CR38","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1124\/pr.110.003293","volume":"63","author":"UB Pandey","year":"2011","unstructured":"Pandey UB, Nichols CD (2011) Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 63(2):411\u2013436. https:\/\/doi.org\/10.1124\/pr.110.003293","journal-title":"Pharmacol Rev"},{"issue":"1","key":"1104_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/17474086.2016.1268047","volume":"10","author":"BT Paul","year":"2017","unstructured":"Paul BT, Manz DH, Torti FM, Torti SV (2017) Mitochondria and Iron: current questions. Expert Rev Hematol 10(1):65\u201379","journal-title":"Expert Rev Hematol"},{"key":"1104_CR40","doi-asserted-by":"crossref","unstructured":"Pesta D, Gnaiger E (2012) High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. In: Mitochondrial bioenergetics. Humana Press,\u00a0Totowa, pp 25\u201358","DOI":"10.1007\/978-1-61779-382-0_3"},{"key":"1104_CR41","doi-asserted-by":"crossref","unstructured":"Pi\u00f1ero DJ, Li NQ, Connor JR, Beard JL (2000) Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr 130(2):254\u2013263","DOI":"10.1093\/jn\/130.2.254"},{"key":"1104_CR42","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cbi.2017.11.018","volume":"279","author":"MR Poetini","year":"2018","unstructured":"Poetini MR, Araujo SM, de Paula MT, Bortolotto VC, Meichtry LB, de Almeida FP, Jesse CR, Kunz SN (2018) Prigol. \u201cHesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson\u2019s disease. Chemico-Biol Interact 279:177\u2013186","journal-title":"Chemico-Biol Interact"},{"key":"1104_CR43","doi-asserted-by":"crossref","unstructured":"Salim S (2017) Oxidative stress and the central nervous system. J Pharmacol Exp Ther 360(1):201\u2013205","DOI":"10.1124\/jpet.116.237503"},{"issue":"4","key":"1104_CR44","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1523\/JNEUROSCI.1305-19.2019","volume":"40","author":"M Sarter","year":"2020","unstructured":"Sarter M, Lustig C (2020) Forebrain cholinergic signaling: wired and phasic, not tonic, and causing behavior. J Neurosci 40(4):712\u2013719","journal-title":"J Neurosci"},{"issue":"6","key":"1104_CR45","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/mds.23732","volume":"26","author":"AH Schapira","year":"2011","unstructured":"Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson\u2019s disease. Mov Disord 26(6):1049\u20131055","journal-title":"Mov Disord"},{"key":"1104_CR46","doi-asserted-by":"crossref","unstructured":"Schneider SA, Obeso JA (2014) Clinical and pathological features of Parkinson\u2019s disease. Behavioral Neurobiology of Huntington\u2019s disease and Parkinson\u2019s disease, pp 205\u2013220","DOI":"10.1007\/7854_2014_317"},{"key":"1104_CR47","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1471-4159.2010.07132.x","volume":"118","author":"J Sian-H\u00fclsmann","year":"2011","unstructured":"Sian-H\u00fclsmann J, Mandel S, Youdim MB, Riederer P (2011) The relevance of iron in the pathogenesis of Parkinson\u2019s disease. J Neurochem 118:6","journal-title":"J Neurochem"},{"issue":"4","key":"1104_CR48","doi-asserted-by":"publisher","first-page":"100131","DOI":"10.1016\/j.phyplu.2021.100131","volume":"1","author":"YH Siddique","year":"2021","unstructured":"Siddique YH, Naz F, Rashid M, Mian S (2021) Effect of Itrifal Muqawwi-e-Dimagh (a polyherbal drug) on the transgenic Drosophila model of Parkinson\u2019s Disease. Phytomed Plus 1(4):100131","journal-title":"Phytomed Plus"},{"key":"1104_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.neuro.2020.09.004","volume":"81","author":"AA Siima","year":"2020","unstructured":"Siima AA, Stephano F, Munissi JJ, Nyandoro SS (2020) Ameliorative effects of flavonoids and polyketides on the rotenone induced Drosophila model of Parkinson\u2019s disease. Neurotoxicology 81:209\u2013215","journal-title":"Neurotoxicology"},{"key":"1104_CR50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-3-030-23396-9_3","volume-title":"Controlled release of pesticides for sustainable agriculture","author":"S Sousa","year":"2020","unstructured":"Sousa S, Maia ML, Correira-S\u00e1 L, Fernandes VC, Delerue-Matos C, Calhau C, Domingues VF (2020) Chemistry and toxicology behind insecticides and herbicides. Controlled release of pesticides for sustainable agriculture. Springer, Cham, pp 59\u2013109"},{"key":"1104_CR51","doi-asserted-by":"crossref","unstructured":"Stephano F, Nolte S, Hoffmann J, El-Kholy S, von Frieling J, Bruchhaus I, Fink C, Roeder T (2018) Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson\u2019s disease model. Sci Rep 8(1):1\u201311","DOI":"10.1038\/s41598-018-20836-w"},{"key":"1104_CR52","doi-asserted-by":"publisher","first-page":"138313","DOI":"10.1016\/j.scitotenv.2020.138313","volume":"725","author":"MS Uddin","year":"2020","unstructured":"Uddin MS, Hossain MF, Al Mamun A, Shah MA, Hasana S, Bulbul IJ, Sarwar MS, Mansouri RA, Rauf GM, Abdel-Daim MM (2020) Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration. Sci Total Environ 725:138313","journal-title":"Sci Total Environ"},{"key":"1104_CR53","unstructured":"US EPA (United States Enviornmental Protection Agency) (2007) https:\/\/archive.epa.gov\/pesticides\/reregistration\/web\/pdf\/rotenone_red.pdf. Accessed 7 July\u00a02016"},{"key":"1104_CR54","doi-asserted-by":"crossref","unstructured":"Wolff SP (1994)\u00a0Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 233:182\u2013189. Academic","DOI":"10.1016\/S0076-6879(94)33021-2"},{"issue":"3","key":"1104_CR55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bbrc.2020.07.025","volume":"531","author":"J Xue","year":"2020","unstructured":"Xue J, Wang HLi, Xiao G (2020) Transferrin1 modulates rotenone-induced Parkinson\u2019s disease through affecting iron homeostasis in Drosophila melanogaster. Biochem Biophys Res Commun 531(3):305\u2013311","journal-title":"Biochem Biophys Res Commun"},{"key":"1104_CR56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/cddis.2017.286","volume":"8","author":"S Zhang","year":"2017","unstructured":"Zhang S, Tang MB, Luo HY, Shi CH, Xu YM (2017) Necroptosis in neurodegenerative diseases: a potential therapeutic target. Cell Death Dis 8:6","journal-title":"Cell Death Dis"},{"key":"1104_CR57","doi-asserted-by":"publisher","first-page":"114829","DOI":"10.1016\/j.taap.2019.114829","volume":"386","author":"L Zhou","year":"2020","unstructured":"Zhou L, Chen L, Zeng X, Liao J, Ouyang D (2020) Ginsenoside compound K alleviates sodium valproate-induced hepatotoxicity in rats via antioxidant effect, regulation of peroxisome pathway and iron homeostasis. Toxicol Appl Pharmcol 386:114829","journal-title":"Toxicol Appl Pharmcol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01104-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-01104-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01104-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T03:17:39Z","timestamp":1673752659000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-01104-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,29]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1104"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-01104-3","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,29]]},"assertion":[{"value":"20 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of <i>Drosophila melanogaster<\/i> requires no formal ethical approval; however, all experiments were performed in the most conducive environment and humane form as possible.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have contributed to the success of this work, read and agree to submit it for consideration in your noble journal. Therefore, we declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}