{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:26:03Z","timestamp":1775798763354,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["931671"],"award-info":[{"award-number":["931671"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s11011-022-01123-0","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T12:02:56Z","timestamp":1668772976000},"page":"621-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure"],"prefix":"10.1007","volume":"38","author":[{"given":"Fatemeh Sadat","family":"Heydari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Gorji Valokola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Abnous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-4263","authenticated-orcid":false,"given":"Ali","family":"Roohbakhsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"1123_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15376516.2019.1652872","volume":"30","author":"MS Alavi","year":"2020","unstructured":"Alavi MS, Shamsizadeh A, Karimi G, Roohbakhsh A (2020) Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe? Toxicol Mech Methods 30:1\u201318. https:\/\/doi.org\/10.1080\/15376516.2019.1652872","journal-title":"Toxicol Mech Methods"},{"key":"1123_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12868-018-0445-9","volume":"19","author":"S Asadi","year":"2018","unstructured":"Asadi S, Roohbakhsh A, Shamsizadeh A, Fereidoni M, Kordijaz E, Moghimi A (2018) The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats. BMC Neurosci 19:49. https:\/\/doi.org\/10.1186\/s12868-018-0445-9","journal-title":"BMC Neurosci"},{"key":"1123_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s11357-019-00083-1","volume":"41","author":"\u00c9 Borb\u00e9ly","year":"2019","unstructured":"Borb\u00e9ly \u00c9, Payrits M, Hunyady \u00c1, Mez\u0151 G, Pint\u00e9r E (2019) Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice. Geroscience 41:643\u2013654. https:\/\/doi.org\/10.1007\/s11357-019-00083-1","journal-title":"Geroscience"},{"key":"1123_CR4","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1113\/jphysiol.2014.277574","volume":"592","author":"GF Buchanan","year":"2014","unstructured":"Buchanan GF, Murray NM, Hajek MA, Richerson GB (2014) Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. J Physiol 592:4395\u20134410. https:\/\/doi.org\/10.1113\/jphysiol.2014.277574","journal-title":"J Physiol"},{"key":"1123_CR5","unstructured":"Clasadonte J, Haydon PG (2012) 4th ed. Astrocytes and epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV (eds) Jasper's basic mechanisms of the epilepsies. National Center for Biotechnology Information (US), Bethesda, Oxford University Press, USA. (Printed in China)"},{"key":"1123_CR6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3171\/jns.2004.101.4.0613","volume":"101","author":"AA Cohen-Gadol","year":"2004","unstructured":"Cohen-Gadol AA, Pan JW, Kim JH, Spencer DD, Hetherington HH (2004) Mesial temporal lobe epilepsy: a proton magnetic resonance spectroscopy study and a histopathological analysis. J Neurosurg 101:613\u2013620. https:\/\/doi.org\/10.3171\/jns.2004.101.4.0613","journal-title":"J Neurosurg"},{"key":"1123_CR7","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1111\/bph.12786","volume":"171","author":"JC de Moura","year":"2014","unstructured":"de Moura JC, Noroes MM, Rachetti Vde P, Soares BL, Preti D, Nassini R, Materazzi S, Marone IM, Minocci D, Geppetti P, Gavioli EC, Andr\u00e9 E (2014) The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice. Br J Pharmacol 171:4289\u20134299. https:\/\/doi.org\/10.1111\/bph.12786","journal-title":"Br J Pharmacol"},{"key":"1123_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejphar.2009.06.038","volume":"617","author":"H Doihara","year":"2009","unstructured":"Doihara H, Nozawa K, Kawabata-Shoda E, Kojima R, Yokoyama T, Ito H (2009) Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs. Eur J Pharmacol 617:124\u2013129. https:\/\/doi.org\/10.1016\/j.ejphar.2009.06.038","journal-title":"Eur J Pharmacol"},{"key":"1123_CR9","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/j.1476-5381.2012.01851.x","volume":"166","author":"ES Fernandes","year":"2012","unstructured":"Fernandes ES, Fernandes MA, Keeble JE (2012) The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol 166:510\u2013521. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.01851.x","journal-title":"Br J Pharmacol"},{"key":"1123_CR10","doi-asserted-by":"publisher","first-page":"134823","DOI":"10.1016\/j.neulet.2020.134823","volume":"721","author":"C G\u00fcnayd\u0131n","year":"2020","unstructured":"G\u00fcnayd\u0131n C, Arslan G, Bilge SS (2020) Proconvulsant effect of trans-cinnamaldehyde in pentylenetetrazole-induced kindling model of epilepsy: The role of TRPA1 channels. Neurosci Lett 721:134823. https:\/\/doi.org\/10.1016\/j.neulet.2020.134823","journal-title":"Neurosci Lett"},{"key":"1123_CR11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature16519","volume":"529","author":"NB Hamilton","year":"2016","unstructured":"Hamilton NB, Kolodziejczyk K, Kougioumtzidou E, Attwell D (2016) Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia. Nature 529:523\u2013527. https:\/\/doi.org\/10.1038\/nature16519","journal-title":"Nature"},{"key":"1123_CR12","doi-asserted-by":"publisher","unstructured":"Jeong JH, Lee SH, Kho AR, Hong DK, Kang DH, Kang BS, Park MK, Choi BY, Choi HC, Lim MS, Suh SW (2020) The transient receptor potential melastatin 7 (trpm7) inhibitors suppress seizure-induced neuron death by inhibiting zinc neurotoxicity. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21217897","DOI":"10.3390\/ijms21217897"},{"key":"1123_CR13","volume-title":"Basic & clinical pharmacology","author":"B Katzung","year":"2021","unstructured":"Katzung B (2021) Basic & clinical pharmacology, 15th edn. McGraw Hill Education, New York","edition":"15"},{"key":"1123_CR14","doi-asserted-by":"publisher","unstructured":"Kheradpezhouh E, Choy JMC, Daria VR, Arabzadeh E (2017) TRPA1 expression and its functional activation in rodent cortex. Open Biol 7. https:\/\/doi.org\/10.1098\/rsob.160314","DOI":"10.1098\/rsob.160314"},{"key":"1123_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10571-012-9875-6","volume":"33","author":"DS Kim","year":"2013","unstructured":"Kim DS, Ryu HJ, Kim JE, Kang TC (2013) The reverse roles of transient receptor potential canonical channel-3 and \u2013 6 in neuronal death following pilocarpine-induced status epilepticus. Cell Mol Neurobiol 33:99\u2013109. https:\/\/doi.org\/10.1007\/s10571-012-9875-6","journal-title":"Cell Mol Neurobiol"},{"key":"1123_CR16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/fcp.12249","volume":"31","author":"E Kordi Jaz","year":"2017","unstructured":"Kordi Jaz E, Moghimi A, Fereidoni M, Asadi S, Shamsizadeh A, Roohbakhsh A (2017) SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. Fundam Clin Pharmacol 31:201\u2013207. https:\/\/doi.org\/10.1111\/fcp.12249","journal-title":"Fundam Clin Pharmacol"},{"key":"1123_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1046\/j.1528-1157.2001.00002.x","volume":"42","author":"H Kupferberg","year":"2001","unstructured":"Kupferberg H (2001) Animal models used in the screening of antiepileptic drugs. Epilepsia 42:7\u201312","journal-title":"Epilepsia"},{"key":"1123_CR18","doi-asserted-by":"publisher","unstructured":"Lajoso W, Flower G, Giacco V, Kaul A, La Mache C, Br\u0103ban A, Roxas A, Hamilton NB (2021) Transient receptor potential ankyrin-1 (trpa1) block protects against loss of white matter function during ischaemia in the mouse optic nerve. Pharmaceuticals (Basel) 14. https:\/\/doi.org\/10.3390\/ph14090909","DOI":"10.3390\/ph14090909"},{"key":"1123_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12974-016-0557-z","volume":"13","author":"KI Lee","year":"2016","unstructured":"Lee KI, Lee HT, Lin HC, Tsay HJ, Tsai FC, Shyue SK, Lee TS (2016) Role of transient receptor potential ankyrin 1 channels in Alzheimer\u2019s disease. J Neuroinflammation 13:92. https:\/\/doi.org\/10.1186\/s12974-016-0557-z","journal-title":"J Neuroinflammation"},{"key":"1123_CR20","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1007\/s12035-016-9908-0","volume":"54","author":"KI Lee","year":"2017","unstructured":"Lee KI, Lin HC, Lee HT, Tsai FC, Lee TS (2017) Loss of transient receptor potential ankyrin 1 channel deregulates emotion, learning and memory, cognition, and social behavior in mice. Mol Neurobiol 54:3606\u20133617. https:\/\/doi.org\/10.1007\/s12035-016-9908-0","journal-title":"Mol Neurobiol"},{"key":"1123_CR21","doi-asserted-by":"publisher","first-page":"493480","DOI":"10.1155\/2014\/493480","volume":"2014","author":"YW Lin","year":"2014","unstructured":"Lin YW, Hsieh CL (2014) Auricular electroacupuncture reduced inflammation-related epilepsy accompanied by altered TRPA1, pPKC\u03b1, pPKC\u03b5, and pERk1\/2 signaling pathways in kainic acid-treated rats. Mediators Inflamm 2014:493480. https:\/\/doi.org\/10.1155\/2014\/493480","journal-title":"Mediators Inflamm"},{"key":"1123_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0920-1211(91)90062-k","volume":"8","author":"W L\u00f6scher","year":"1991","unstructured":"L\u00f6scher W, H\u00f6nack D, Fassbender CP, Nolting B (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res 8:171\u2013189. https:\/\/doi.org\/10.1016\/0920-1211(91)90062-k","journal-title":"Epilepsy Res"},{"key":"1123_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2014_18","volume":"167","author":"R Nassini","year":"2014","unstructured":"Nassini R, Materazzi S, Benemei S, Geppetti P (2014) The TRPA1 channel in inflammatory and neuropathic pain and migraine. Rev Physiol Biochem Pharmacol 167:1\u201343. https:\/\/doi.org\/10.1007\/112_2014_18","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"1123_CR24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s11011-021-00684-w","volume":"36","author":"EO Okwuofu","year":"2021","unstructured":"Okwuofu EO, Ogundepo GE, Akhigbemen AM, Abiola AL, Ozolua RI, Igbe I, Chinazamoku O (2021) Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. Metab Brain Dis 36:571\u2013579. https:\/\/doi.org\/10.1007\/s11011-021-00684-w","journal-title":"Metab Brain Dis"},{"key":"1123_CR25","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2018","unstructured":"Paxinos G, Watson C (2018) The rat brain in stereotaxic coordinates, 7th edn. Academic, San Diego","edition":"7"},{"key":"1123_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2021.07.011","volume":"175","author":"DS Peres","year":"2021","unstructured":"Peres DS, Theisen MC, Fialho MFP, Dalenogare DP, Rodrigues P, Kudsi SQ, Bernardes LB, Ruviaro da Silva NA, L\u00fcckemeyer DD, Sampaio TB, Pereira GC, Mello FK, Ferreira J, Bochi GV, Oliveira SM, de Antoniazzi D, Trevisan CT (2021) TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice. Brain Res Bull 175:1\u201315. https:\/\/doi.org\/10.1016\/j.brainresbull.2021.07.011","journal-title":"Brain Res Bull"},{"key":"1123_CR27","doi-asserted-by":"publisher","first-page":"11533","DOI":"10.1073\/pnas.1411442111","volume":"111","author":"KD Phelan","year":"2014","unstructured":"Phelan KD, Shwe UT, Abramowitz J, Birnbaumer L, Zheng F (2014) Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proc Natl Acad Sci U S A 111:11533\u201311538. https:\/\/doi.org\/10.1073\/pnas.1411442111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1123_CR28","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1124\/mol.112.082271","volume":"83","author":"KD Phelan","year":"2013","unstructured":"Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F (2013) Canonical transient receptor channel 5 (TRPC5) and TRPC1\/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol 83:429\u2013438. https:\/\/doi.org\/10.1124\/mol.112.082271","journal-title":"Mol Pharmacol"},{"key":"1123_CR29","doi-asserted-by":"publisher","unstructured":"Pires PW, Earley S (2018) Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke. Elife 7. https:\/\/doi.org\/10.7554\/eLife.35316","DOI":"10.7554\/eLife.35316"},{"key":"1123_CR30","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1002\/glia.23051","volume":"64","author":"\u00c9 S\u00e1ghy","year":"2016","unstructured":"S\u00e1ghy \u00c9, Sipos \u00c9, \u00c1cs P, B\u00f6lcskei K, Poh\u00f3czky K, Kem\u00e9ny \u00c1, S\u00e1ndor Z, Sz\u0151ke \u00c9, S\u00e9t\u00e1l\u00f3 G Jr, Komoly S, Pint\u00e9r E (2016) TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis. Glia 64:2166\u20132180. https:\/\/doi.org\/10.1002\/glia.23051","journal-title":"Glia"},{"key":"1123_CR31","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.brainresrev.2009.10.004","volume":"63","author":"G Seifert","year":"2010","unstructured":"Seifert G, Carmignoto G, Steinh\u00e4user C (2010) Astrocyte dysfunction in epilepsy. Brain Res Rev 63:212\u2013221. https:\/\/doi.org\/10.1016\/j.brainresrev.2009.10.004","journal-title":"Brain Res Rev"},{"key":"1123_CR32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40035-021-00239-0","volume":"10","author":"L Shi","year":"2021","unstructured":"Shi L, Lin Y, Jiao Y, Herr SA, Tang J, Rogers E, Chen Z, Shi R (2021) Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson\u2019s disease: implication of acrolein and TRPA1. Transl Neurodegener 10:13. https:\/\/doi.org\/10.1186\/s40035-021-00239-0","journal-title":"Transl Neurodegener"},{"key":"1123_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nn.3000","volume":"15","author":"E Shigetomi","year":"2011","unstructured":"Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS (2011) TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 15:70\u201380. https:\/\/doi.org\/10.1038\/nn.3000","journal-title":"Nat Neurosci"},{"key":"1123_CR34","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s10072-014-1689-5","volume":"35","author":"M Shirazi","year":"2014","unstructured":"Shirazi M, Izadi M, Amin M, Rezvani ME, Roohbakhsh A, Shamsizadeh A (2014) Involvement of central TRPV1 receptors in pentylenetetrazole and amygdala-induced kindling in male rats. Neurol Sci 35:1235\u20131241. https:\/\/doi.org\/10.1007\/s10072-014-1689-5","journal-title":"Neurol Sci"},{"key":"1123_CR35","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/14728222.2020.1815191","volume":"24","author":"D Souza Monteiro de Araujo","year":"2020","unstructured":"Souza Monteiro de Araujo D, Nassini R, Geppetti P, De Logu F (2020) TRPA1 as a therapeutic target for nociceptive pain. Expert Opin Ther Targets 24:997\u20131008. https:\/\/doi.org\/10.1080\/14728222.2020.1815191","journal-title":"Expert Opin Ther Targets"},{"key":"1123_CR36","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1097\/WNR.0b013e32832d2219","volume":"20","author":"B Sun","year":"2009","unstructured":"Sun B, Bang SI, Jin YH (2009) Transient receptor potential A1 increase glutamate release on brain stem neurons. NeuroReport 20:1002\u20131006. https:\/\/doi.org\/10.1097\/WNR.0b013e32832d2219","journal-title":"NeuroReport"},{"key":"1123_CR37","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1152\/physrev.00005.2019","volume":"100","author":"K Talavera","year":"2020","unstructured":"Talavera K, Startek JB, Alvarez-Collazo J, Boonen B, Alpizar YA, Sanchez A, Naert R, Nilius B (2020) Mammalian transient receptor potential TRPA1 channels: From structure to disease. Physiol Rev 100:725\u2013803. https:\/\/doi.org\/10.1152\/physrev.00005.2019","journal-title":"Physiol Rev"},{"key":"1123_CR38","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.psc.2020.02.002","volume":"43","author":"B Tolchin","year":"2020","unstructured":"Tolchin B, Hirsch LJ, LaFrance WC Jr (2020) Neuropsychiatric aspects of epilepsy. Psychiatr Clin North Am 43:275\u2013290. https:\/\/doi.org\/10.1016\/j.psc.2020.02.002","journal-title":"Psychiatr Clin North Am"},{"key":"1123_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.02.003","author":"XJ Yang","year":"2022","unstructured":"Yang XJ, Ling SZ, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC (2022) Inhibition of TRPA1 attenuates oxidative stress-induced damage after traumatic brain injury via the ERK\/AKT signaling pathway. Neuroscience. https:\/\/doi.org\/10.1016\/j.neuroscience.2022.02.003","journal-title":"Neuroscience"},{"key":"1123_CR40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejphar.2011.01.011","volume":"655","author":"T Yokoyama","year":"2011","unstructured":"Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Uezono Y, Ueta Y (2011) Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. Eur J Pharmacol 655:31\u201337. https:\/\/doi.org\/10.1016\/j.ejphar.2011.01.011","journal-title":"Eur J Pharmacol"},{"key":"1123_CR41","doi-asserted-by":"publisher","first-page":"86","DOI":"10.21307\/ane-2019-007","volume":"79","author":"N Zandi","year":"2019","unstructured":"Zandi N, Zaniani NR, Moghimi A, Roohbakhsh A (2019) Protective effects of M8\u2013B, a TRPM8 antagonist, on febrile\u2013 and pentylenetetrazol\u2013induced seizures. Acta Neurobiol Exp (Wars) 79:86\u201391. https:\/\/doi.org\/10.21307\/ane-2019-007","journal-title":"Acta Neurobiol Exp (Wars)"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01123-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-022-01123-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-022-01123-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T15:25:03Z","timestamp":1674228303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-022-01123-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1123"],"URL":"https:\/\/doi.org\/10.1007\/s11011-022-01123-0","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"assertion":[{"value":"5 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted according to the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals, and the protocol was approved by the Institutional Animal Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that there are no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}