{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:19Z","timestamp":1788544159457,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11011-023-01159-w","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:56:54Z","timestamp":1674262614000},"page":"1389-1404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gli2-induced lncRNA Peg13 alleviates cerebral ischemia-reperfusion injury by suppressing Yy1 transcription in a PRC2 complex-dependent manner"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-6294","authenticated-orcid":false,"given":"Yanling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"1159_CR1","doi-asserted-by":"publisher","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","volume":"220","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A (2021) LNCcation: lncRNA localization and function. J Cell Biol 220:e202009045","journal-title":"J Cell Biol"},{"key":"1159_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuint.2017.01.015","volume":"111","author":"R Chandran","year":"2017","unstructured":"Chandran R, Mehta SL, Vemuganti R (2017) Non-coding RNAs and neuroprotection after acute CNS injuries. Neurochem Int 111:12\u201322","journal-title":"Neurochem Int"},{"key":"1159_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuroscience.2016.01.033","volume":"319","author":"R Chen","year":"2016","unstructured":"Chen R, Liu L, Xiao M, Wang F, Lin X (2016) Microarray expression profile analysis of long noncoding RNAs in premature brain injury: a novel point of view. Neuroscience 319:123\u2013133","journal-title":"Neuroscience"},{"key":"1159_CR4","doi-asserted-by":"publisher","first-page":"116553","DOI":"10.1016\/j.lfs.2019.116553","volume":"235","author":"L Chen","year":"2019","unstructured":"Chen L, Cao J, Cao D, Wang M, Xiang H, Yang Y, Ying T, Cong H (2019) Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia\/reperfusion injury: an in vivo and in vitro study. Life Sci 235:116553","journal-title":"Life Sci"},{"key":"1159_CR5","doi-asserted-by":"crossref","unstructured":"Cui Y, Fang J, Guo H, Cui H, Deng J, Yu S, Gou L, Wang F, Ma X, Ren Z, Xie Y, Geng Y, Wang Y, Zuo Z (2022) Notch3-Mediated mTOR Signaling pathway is involved in high Glucose-Induced autophagy in bovine kidney epithelial cells. Molecules 27.","DOI":"10.3390\/molecules27103121"},{"key":"1159_CR6","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1002\/jcp.29334","volume":"235","author":"W Deng","year":"2020","unstructured":"Deng W, Fan C, Shen R, Wu Y, Du R, Teng J (2020) Long noncoding MIAT acting as a ceRNA to sponge microRNA-204-5p to participate in cerebral microvascular endothelial cell injury after cerebral ischemia through regulating HMGB1. J Cell Physiol 235:4571\u20134586","journal-title":"J Cell Physiol"},{"key":"1159_CR7","doi-asserted-by":"publisher","first-page":"17649","DOI":"10.1002\/jcp.28388","volume":"234","author":"L Diao","year":"2019","unstructured":"Diao L, Bai L, Jiang X, Li J, Zhang Q (2019) Long-chain noncoding RNA GAS5 mediates oxidative stress in cardiac microvascular endothelial cells injury. J Cell Physiol 234:17649\u201317662","journal-title":"J Cell Physiol"},{"key":"1159_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41419-019-1840-6","volume":"10","author":"J Fan","year":"2019","unstructured":"Fan J, Zhang X, Wang S, Chen W, Li Y, Zeng X, Wang Y, Luan J, Li L, Wang Z, Sun X, Shen B, Ju D (2019) Regulating autophagy facilitated therapeutic efficacy of the sonic hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production. Cell Death Dis 10:626","journal-title":"Cell Death Dis"},{"key":"1159_CR9","first-page":"7968","volume":"12","author":"H Feng","year":"2020","unstructured":"Feng H, Gui Q, Zhu W, Wu G, Dong X, Shen M, Luo H, Xue S, Cheng Q (2020) Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p\/Psmd11 axis to inactivate the Wnt\/\u03b2-catenin pathway. Am J translational Res 12:7968\u20137981","journal-title":"Am J translational Res"},{"key":"1159_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neuroscience.2020.03.027","volume":"435","author":"C Gao","year":"2020","unstructured":"Gao C, Zhang CC, Yang HX, Hao YN (2020) MALAT1 protected the angiogenesis function of human brain microvascular endothelial cells (HBMECs) under oxygen glucose Deprivation\/re-oxygenation (OGD\/R) challenge by interacting with miR-205-5p\/VEGFA pathway. Neuroscience 435:135\u2013145","journal-title":"Neuroscience"},{"key":"1159_CR11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1007\/s11064-021-03474-z","volume":"47","author":"H Gao","year":"2022","unstructured":"Gao H, Zhang Y, Xue H, Zhang Q, Zhang Y, Shen Y, Bing X (2022) Long non-coding RNA Peg13 alleviates hypoxic-ischemic brain damage in neonatal mice via miR-20a-5p\/XIAP Axis. Neurochem Res 47:656\u2013666","journal-title":"Neurochem Res"},{"key":"1159_CR12","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/sj.onc.1209080","volume":"25","author":"S Gordon","year":"2006","unstructured":"Gordon S, Akopyan G, Garban H, Bonavida B (2006) Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25:1125\u20131142","journal-title":"Oncogene"},{"key":"1159_CR13","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1089\/dna.2017.3857","volume":"36","author":"T Huang","year":"2017","unstructured":"Huang T, Wang G, Yang L, Peng B, Wen Y, Ding G, Wang Z (2017) Transcription factor YY1 modulates Lung Cancer Progression by activating lncRNA-PVT1. DNA Cell Biol 36:947\u2013958","journal-title":"DNA Cell Biol"},{"key":"1159_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13046-018-0917-x","volume":"37","author":"D Huang","year":"2018","unstructured":"Huang D, Wang Y, Xu L, Chen L, Cheng M, Shi W, Xiong H, Zalli D, Luo S (2018) GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells. J experimental Clin cancer research: CR 37:247","journal-title":"J experimental Clin cancer research: CR"},{"key":"1159_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/JLB.1A0421-190R","volume":"111","author":"D Huang","year":"2022","unstructured":"Huang D, Cao Y, Zu T, Ju J (2022) Interference with long noncoding RNA SNHG3 alleviates cerebral ischemia-reperfusion injury by inhibiting microglial activation. J Leukoc Biol 111:759\u2013769","journal-title":"J Leukoc Biol"},{"key":"1159_CR16","doi-asserted-by":"publisher","first-page":"D260","DOI":"10.1093\/nar\/gkx1126","volume":"46","author":"A Khan","year":"2018","unstructured":"Khan A, Fornes O, Stigliani A, Gheorghe M, Castro-Mondragon JA, van der Lee R, Bessy A, Ch\u00e8neby J, Kulkarni SR, Tan G, Baranasic D, Arenillas DJ, Sandelin A, Vandepoele K, Lenhard B, Ballester B, Wasserman WW, Parcy F, Mathelier A (2018) JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework. Nucleic Acids Res 46:D260\u2013d266","journal-title":"Nucleic Acids Res"},{"key":"1159_CR17","doi-asserted-by":"publisher","first-page":"9071","DOI":"10.18632\/aging.202762","volume":"13","author":"F Kuai","year":"2021","unstructured":"Kuai F, Zhou L, Zhou J, Sun X, Dong W (2021) Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor \u03baB p65 signaling. Aging 13:9071\u20139084","journal-title":"Aging"},{"key":"1159_CR18","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3389\/fnins.2019.00645","volume":"13","author":"Y Li","year":"2019","unstructured":"Li Y, Guo S, Liu W, Jin T, Li X, He X, Zhang X, Su H, Zhang N, Duan C (2019) Silencing of SNHG12 enhanced the effectiveness of MSCs in alleviating Ischemia\/Reperfusion injuries via the PI3K\/AKT\/mTOR signaling pathway. Front Neurosci 13:645","journal-title":"Front Neurosci"},{"key":"1159_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fphar.2020.00064","volume":"11","author":"L Li","year":"2020","unstructured":"Li L, Sun L, Qiu Y, Zhu W, Hu K, Mao J (2020) Protective effect of Stachydrine Against Cerebral Ischemia-Reperfusion Injury by reducing inflammation and apoptosis through P65 and JAK2\/STAT3 signaling pathway. Front Pharmacol 11:64","journal-title":"Front Pharmacol"},{"key":"1159_CR20","doi-asserted-by":"publisher","first-page":"6873","DOI":"10.7150\/thno.49235","volume":"11","author":"X Li","year":"2021","unstructured":"Li X, Gera L, Zhang S, Chen Y, Lou L, Wilson LM, Xie ZR, Sautto G, Liu D, Danaher A, Mamouni K, Yang Y, Du Y, Fu H, Kucuk O, Osunkoya AO, Zhou J, Wu D (2021) Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer. Theranostics 11:6873\u20136890","journal-title":"Theranostics"},{"key":"1159_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13046-020-01598-8","volume":"39","author":"Y Liu","year":"2020","unstructured":"Liu Y, Song J, Liu Y, Zhou Z, Wang X (2020) Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a\/b\/c-3p to upregulate STAT3\/Gli2. J experimental Clin cancer research: CR 39:101","journal-title":"J experimental Clin cancer research: CR"},{"key":"1159_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11010-012-1396-6","volume":"370","author":"Y-L Lou","year":"2012","unstructured":"Lou Y-L, Guo F, Liu F, Gao F-L, Zhang P-Q, Niu X, Guo S-C, Yin J-H, Wang Y, Deng Z-F (2012) miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia. Mol Cell Biochem 370:45\u201351","journal-title":"Mol Cell Biochem"},{"key":"1159_CR23","doi-asserted-by":"publisher","first-page":"17739","DOI":"10.1002\/jcp.28399","volume":"234","author":"J Ma","year":"2019","unstructured":"Ma J, Huang X, Li Z, Shen Y, Lai J, Su Q, Zhao J, Xu J (2019) FOXE1 supports the tumor promotion of Gli2 on papillary thyroid carcinoma by the Wnt\/beta-catenin pathway. J Cell Physiol 234:17739\u201317748","journal-title":"J Cell Physiol"},{"key":"1159_CR24","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ccell.2018.07.009","volume":"34","author":"O Meurette","year":"2018","unstructured":"Meurette O, Mehlen P (2018) Notch signaling in the tumor microenvironment. Cancer Cell 34:536\u2013548","journal-title":"Cancer Cell"},{"key":"1159_CR25","doi-asserted-by":"publisher","first-page":"10846","DOI":"10.1074\/jbc.M608599200","volume":"282","author":"Y Pan","year":"2007","unstructured":"Pan Y, Wang B (2007) A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J Biol Chem 282:10846\u201310852","journal-title":"J Biol Chem"},{"key":"1159_CR26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3389\/fnins.2019.00321","volume":"13","author":"L Peng","year":"2019","unstructured":"Peng L, Yin J, Ge M, Wang S, Xie L, Li Y, Si JQ, Ma K (2019a) Isoflurane post-conditioning ameliorates cerebral Ischemia\/Reperfusion Injury by enhancing Angiogenesis through activating the Shh\/Gli signaling pathway in rats. Front Neurosci 13:321","journal-title":"Front Neurosci"},{"key":"1159_CR27","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1007\/s11064-019-02880-8","volume":"44","author":"L Peng","year":"2019","unstructured":"Peng L, Yin J, Wang S, Ge M, Han Z, Wang Y, Zhang M, Xie L, Li Y (2019b) TGF-beta2\/Smad3 signaling pathway activation through enhancing VEGF and CD34 ameliorates cerebral Ischemia\/Reperfusion Injury after isoflurane post-conditioning in rats. Neurochem Res 44:2606\u20132618","journal-title":"Neurochem Res"},{"key":"1159_CR28","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00018-016-2174-5","volume":"73","author":"SU Schmitz","year":"2016","unstructured":"Schmitz SU, Grote P, Herrmann BG (2016) Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci 73:2491\u20132509","journal-title":"Cell Mol Life Sci"},{"key":"1159_CR29","doi-asserted-by":"publisher","first-page":"39051","DOI":"10.1074\/jbc.M111.274993","volume":"286","author":"EK Schrader","year":"2011","unstructured":"Schrader EK, Harstad KG, Holmgren RA, Matouschek A (2011) A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome. J Biol Chem 286:39051\u201339058","journal-title":"J Biol Chem"},{"key":"1159_CR30","doi-asserted-by":"publisher","first-page":"e924781","DOI":"10.12659\/MSM.924781","volume":"26","author":"S Shen","year":"2020","unstructured":"Shen S, Ma L, Shao F, Jin L, Bian Z (2020) Long non-coding RNA (lncRNA) NEAT1 aggravates cerebral ischemia-reperfusion Injury by suppressing the Inhibitory Effect of miR-214 on PTEN. Med Sci Monit 26:e924781","journal-title":"Med Sci Monit"},{"key":"1159_CR31","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nrc1991","volume":"6","author":"A Sparmann","year":"2006","unstructured":"Sparmann A, van Lohuizen M (2006) Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6:846\u2013856","journal-title":"Nat Rev Cancer"},{"key":"1159_CR32","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/s41417-020-00282-5","volume":"28","author":"S Tanigawa","year":"2021","unstructured":"Tanigawa S, Fujita M, Moyama C, Ando S, Ii H, Kojima Y, Fujishita T, Aoki M, Takeuchi H, Yamanaka T, Takahashi Y, Hashimoto N, Nakata S (2021) Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model. Cancer Gene Ther 28:1339\u20131352","journal-title":"Cancer Gene Ther"},{"key":"1159_CR33","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s12031-018-1253-5","volume":"67","author":"R Tian","year":"2019","unstructured":"Tian R, Wang S (2019) Electroacupuncture reduced apoptosis of hippocampal neurons in mice with cerebral infarction by regulating the Notch3 signaling pathway. J Mol Neurosci 67:456\u2013466","journal-title":"J Mol Neurosci"},{"key":"1159_CR34","doi-asserted-by":"crossref","unstructured":"Wan H, Yang Y, Li M, Liu X, Sun Y, Wang K, Zhang C, Zheng Q, Wang C (2019) Correction for: Activation of AK005401 aggravates acute ischemia\/reperfusion mediated hippocampal injury by directly targeting YY1\/FGF21. Aging 11:9960","DOI":"10.18632\/aging.102458"},{"key":"1159_CR35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.brainresbull.2021.05.018","volume":"173","author":"C Wang","year":"2021","unstructured":"Wang C, Hu F (2021) Long noncoding RNA SOX2OT silencing alleviates cerebral ischemia-reperfusion injury via miR-135a-5p-mediated NR3C2 inhibition. Brain Res Bull 173:193\u2013202","journal-title":"Brain Res Bull"},{"key":"1159_CR36","doi-asserted-by":"crossref","unstructured":"Warowicka A, Broniarczyk J, Weglewska M, Kwasniewski W, Gozdzicka-Jozefiak A (2022) Dual role of YY1 in HPV Life Cycle and Cervical Cancer Development.Int J Mol Sci23","DOI":"10.3390\/ijms23073453"},{"key":"1159_CR37","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1007\/s12035-020-02206-8","volume":"58","author":"M Wolska","year":"2021","unstructured":"Wolska M, Jarosz-Popek J, Junger E, Wicik Z, Porshoor T, Sharif L, Czajka P, Postula M, Mirowska-Guzel D, Czlonkowska A, Eyileten C (2021) Long non-coding RNAs as Promising Therapeutic Approach in ischemic stroke: a Comprehensive Review. Mol Neurobiol 58:1664\u20131682","journal-title":"Mol Neurobiol"},{"key":"1159_CR38","first-page":"996","volume":"117","author":"Q Yang","year":"2012","unstructured":"Yang Q, Yan W, Li X, Hou L, Dong H, Wang Q, Dong H, Wang S, Zhang X, Xiong L (2012) Activation of canonical notch signaling pathway is involved in the ischemic tolerance induced by sevoflurane preconditioning in mice. J Am Soc Anesthesiologists 117:996\u20131005","journal-title":"J Am Soc Anesthesiologists"},{"key":"1159_CR39","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1111\/jcmm.13503","volume":"22","author":"S Zhan","year":"2018","unstructured":"Zhan S, Wang T, Ge W, Li J (2018) Multiple roles of Ring 1 and YY1 binding protein in physiology and disease. J Cell Mol Med 22:2046\u20132054","journal-title":"J Cell Mol Med"},{"key":"1159_CR40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12017-013-8273-7","volume":"16","author":"H-p Zhang","year":"2014","unstructured":"Zhang H-p, Sun Y-y, Chen X-m, Yuan L-b, Su B-x, Ma R, Zhao R-n, Dong H-l, Xiong L (2014) The neuroprotective effects of isoflurane preconditioning in a murine transient global cerebral ischemia\u2013reperfusion model: the role of the notch signaling pathway. Neuromol Med 16:191\u2013204","journal-title":"Neuromol Med"},{"key":"1159_CR41","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.expneurol.2015.12.014","volume":"277","author":"J Zhang","year":"2016","unstructured":"Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ (2016) Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162\u2013170","journal-title":"Exp Neurol"},{"key":"1159_CR42","doi-asserted-by":"publisher","first-page":"107682","DOI":"10.1016\/j.neuropharm.2019.107682","volume":"158","author":"XC Zhang","year":"2019","unstructured":"Zhang XC, Gu AP, Zheng CY, Li YB, Liang HF, Wang HJ, Tang XL, Bai XX, Cai J (2019a) YY1\/LncRNA GAS5 complex aggravates cerebral ischemia\/reperfusion injury through enhancing neuronal glycolysis. Neuropharmacology 158:107682","journal-title":"Neuropharmacology"},{"key":"1159_CR43","first-page":"2429","volume":"43","author":"YY Zhang","year":"2019","unstructured":"Zhang YY, Wang K, Liu YE, Wang W, Liu AF, Zhou J, Li C, Zhang YQ, Zhang AP, Lv J, Jiang WJ (2019b) Identification of key transcription factors associated with cerebral ischemiareperfusion injury based on geneset enrichment analysis. Int J Mol Med 43:2429\u20132439","journal-title":"Int J Mol Med"},{"key":"1159_CR44","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.ymthe.2019.11.015","volume":"28","author":"F Zhang","year":"2020","unstructured":"Zhang F, Ruan X, Ma J, Liu X, Zheng J, Liu Y, Liu L, Shen S, Shao L, Wang D, Yang C, Cai H, Li Z, Feng Z, Xue Y (2020) DGCR8\/ZFAT-AS1 promotes CDX2 transcription in a PRC2 complex-dependent manner to facilitate the malignant Biological Behavior of Glioma cells. Mol Ther 28:613\u2013630","journal-title":"Mol Ther"},{"key":"1159_CR45","doi-asserted-by":"crossref","unstructured":"Zhou Z, Qi D, Gan Q, Wang F, Qin B, Li J, Wang H, Wang D (2021) Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System. Oxidative medicine and cellular longevity 2021:6657944","DOI":"10.1155\/2021\/6657944"},{"key":"1159_CR46","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s11011-016-9868-0","volume":"31","author":"CY Zhu","year":"2016","unstructured":"Zhu CY, Wang Y, Zeng QX, Qian Y, Li H, Yang ZX, Yang YM, Zhang Q, Li FF, Liu SL (2016) Combined effects of age and polymorphisms in Notch3 in the pathogenesis of cerebral infarction disease. Metab Brain Dis 31:1157\u20131164","journal-title":"Metab Brain Dis"},{"key":"1159_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1248\/cpb.c19-00550","volume":"68","author":"K Zhu","year":"2020","unstructured":"Zhu K, Du D, Yang R, Tao H, Zhang H (2020) Identification and assessments of Novel and Potent Small-Molecule inhibitors of EED-EZH2 Interaction of polycomb repressive complex 2 by computational methods and biological evaluations. Chem Pharm Bull 68:58\u201363","journal-title":"Chem Pharm Bull"},{"key":"1159_CR48","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1007\/s11064-022-03544-w","volume":"47","author":"T Zhu","year":"2022","unstructured":"Zhu T, Chen H, He C, Liu X (2022) Transcription factor HEY1 improves brain vascular endothelial cell function and alleviates ischemic stroke by upregulating NOTCH3. Neurochem Res 47:1442\u20131458","journal-title":"Neurochem Res"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-023-01159-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-023-01159-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-023-01159-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T06:14:25Z","timestamp":1681712065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-023-01159-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1159"],"URL":"https:\/\/doi.org\/10.1007\/s11011-023-01159-w","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"1 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Animal Care and Use Committee of the Second Affiliated Hospital of Xi\u2019an Jiaotong University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}