{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:41:13Z","timestamp":1775644873174,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002966","name":"Sivas Cumhuriyet \u00dcniversitesi","doi-asserted-by":"publisher","award":["T-856"],"award-info":[{"award-number":["T-856"]}],"id":[{"id":"10.13039\/501100002966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s11011-023-01226-2","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T08:02:17Z","timestamp":1683360137000},"page":"2145-2158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-1053","authenticated-orcid":false,"given":"Ercan","family":"Ozdemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-754X","authenticated-orcid":false,"given":"Onur","family":"Avc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-4448","authenticated-orcid":false,"given":"Zeynep Deniz Sahin","family":"Inan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-8415","authenticated-orcid":false,"given":"Ahmet Sevki","family":"Taskiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-8264","authenticated-orcid":false,"given":"Handan","family":"Gunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0259-9750","authenticated-orcid":false,"given":"Sinan","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"issue":"4","key":"1226_CR1","first-page":"433","volume":"34","author":"A Altun","year":"2015","unstructured":"Altun A, Ozdemir E, Yildirim K, Gursoy S, Durmus N, Bagcivan I (2015) The effects of endocannabinoid receptor agonist anandamide and antagonist rimonabant on opioid analgesia and tolerance in rats. Gen Physiol Biophys 34(4):433\u2013440","journal-title":"Gen Physiol Biophys"},{"issue":"5","key":"1226_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1139\/cjpp-2020-0218","volume":"99","author":"T Baser","year":"2021","unstructured":"Baser T, Ozdemir E, Filiz AK, Taskiran AS, Gursoy S (2021) Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. Can J Physiol Pharmacol 99(5):461\u2013467","journal-title":"Can J Physiol Pharmacol"},{"key":"1226_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3233\/JAD-2010-100309","volume":"22","author":"A Blanco","year":"2010","unstructured":"Blanco A, Alvarez S, Fresno M, Mu\u00f1oz-Fern\u00e1ndez M (2010) Amyloid-\u03b2 induces cyclooxygenase-2 and PgE2 release in human astrocytes in NF-\u03baB dependent manner. J Alzheimers dis 22:493\u2013505","journal-title":"J Alzheimers dis"},{"issue":"6","key":"1226_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1097\/FBP.0000000000000642","volume":"32","author":"DC Boorman","year":"2021","unstructured":"Boorman DC, Keay KA (2021) Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model. Behav Pharmacol 32(6):479\u2013486","journal-title":"Behav Pharmacol"},{"issue":"1","key":"1226_CR5","doi-asserted-by":"publisher","first-page":"e0146427","DOI":"10.1371\/journal.pone.0146427","volume":"11","author":"S Castany","year":"2016","unstructured":"Castany S, Carcol\u00e9 M, Le\u00e1nez S, Pol O (2016) The induction of heme oxygenase-1 decreases painful diabetic neuropathy and enhances the antinociceptive effects of morphine in diabetic mice. PLoS ONE 11(1):e0146427","journal-title":"PLoS ONE"},{"key":"1226_CR6","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1213\/ANE.0b013e3181f1bb9a","volume":"111","author":"M Charkhpour","year":"2010","unstructured":"Charkhpour M, Nayebi AR, Doustar Y, Hassanzadeh K (2010) 8-OH-DPAT prevents morphine-induced apoptosis in rat dorsal raphe nucleus: a possible mechanism for attenuating morphine tolerance. Anesth Analg 111:1316\u20131321","journal-title":"Anesth Analg"},{"key":"1226_CR7","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1097\/00000542-200312000-00026","volume":"99","author":"SR Chen","year":"2003","unstructured":"Chen SR, Pan HL (2003) Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology 99:1409\u20131414","journal-title":"Anesthesiology"},{"issue":"5","key":"1226_CR8","first-page":"CD011669","volume":"5","author":"TE Cooper","year":"2017","unstructured":"Cooper TE, Chen J, Wiffen PJ et al (2017) Morphine for chronic neuropathic pain in adults. Cochrane Database Syst Rev 5(5):CD011669","journal-title":"Cochrane Database Syst Rev"},{"key":"1226_CR9","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nm.4262","volume":"23","author":"G Corder","year":"2017","unstructured":"Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR et al (2017) Loss of \u00b5 opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat Med 23:164\u2013173","journal-title":"Nat Med"},{"issue":"6","key":"1226_CR10","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1471-4159.2005.03157.x","volume":"93","author":"P Crisanti","year":"2005","unstructured":"Crisanti P, Leon A, Lim DM, Omri B (2005) Aspirin prevention of NMDA-induced neuronal death by direct protein kinase czeta inhibition. J Neurochem 93(6):1587\u20131593","journal-title":"J Neurochem"},{"key":"1226_CR12","first-page":"637","volume":"4","author":"X Feng","year":"2011","unstructured":"Feng X, Lu B, Xu Y, Li Q, Zhou W, Yang Z et al (2011) Aspirin reduces the apoptotic effect of etoposide via akt activation and up-regulation of p21(cip). Int J Mol Med 4:637\u2013643","journal-title":"Int J Mol Med"},{"key":"1226_CR11","doi-asserted-by":"publisher","first-page":"3682034","DOI":"10.1155\/2021\/3682034","volume":"2021","author":"D Feng","year":"2021","unstructured":"Feng D, Chen D, Chen T, Sun X (2021) Aspirin exerts neuroprotective effects by reversing lipopolysaccharide-induced secondary brain injury and inhibiting matrix metalloproteinase-3 gene expression. Dis Markers 2021:3682034","journal-title":"Dis Markers"},{"key":"1226_CR13","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.2337\/diab.34.11.1104","volume":"34","author":"LJ Forman","year":"1985","unstructured":"Forman LJ, Marquis DE, Stevens R, Adler R, Vasilenko P (1985) Diabetes induced by STZ results in a decrease in immunoreactive beta-endorphin levels in the pituitary and hypothalamus of female rats. Diabetes 34:1104\u20131107","journal-title":"Diabetes"},{"key":"1226_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1533-2500.2007.00119.x","volume":"7","author":"E Freye","year":"2007","unstructured":"Freye E, Anderson-Hillemacher A, Ritzdorf I, Levy JV (2007) Opioid rotation from high-dose morphine to transdermal buprenorphine (Transtec) in chronic pain patients. Pain Pract 7:123\u2013129","journal-title":"Pain Pract"},{"key":"1226_CR15","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1126\/science.274.5291.1383","volume":"274","author":"M Grilli","year":"1996","unstructured":"Grilli M, Pizzi M, Memo M, Spano P (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383\u20131385","journal-title":"Science"},{"issue":"5","key":"1226_CR16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3390\/biomedicines9050573","volume":"9","author":"M Gupta","year":"2021","unstructured":"Gupta M, Knezevic NN, Abd-Elsayed A et al (2021) Treatment of painful diabetic neuropathy-a narrative review of pharmacological and interventional approaches. Biomedicines 9(5):573","journal-title":"Biomedicines"},{"issue":"4","key":"1226_CR17","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s12640-010-9212-0","volume":"19","author":"K Hassanzadeh","year":"2011","unstructured":"Hassanzadeh K, Habibi-asl B, Farajnia S, Roshangar L (2011) Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance. Neurotox Res 19(4):649\u2013659","journal-title":"Neurotox Res"},{"key":"1226_CR18","doi-asserted-by":"publisher","first-page":"174480691666628","DOI":"10.1177\/1744806916666283","volume":"12","author":"XM Hu","year":"2016","unstructured":"Hu XM, Cao SB, Zhang HL, Lyu DM, Chen LP, Xu H et al (2016) Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKII\u03b3. Mol Pain 12:1744806916666283","journal-title":"Mol Pain"},{"key":"1226_CR19","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/jcmm.12812","volume":"20","author":"Z Jian","year":"2016","unstructured":"Jian Z, Tang L, Yi X, Liu B, Zhang Q, Zhu G et al (2016) Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2 O2-induced oxidative stress. J Cell Mol Med 20:1307\u20131318","journal-title":"J Cell Mol Med"},{"key":"1226_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuroscience.2018.01.048","volume":"375","author":"V Jokinen","year":"2018","unstructured":"Jokinen V, Sidorova Y, Visanen H, Suleymanova I, Tiilikainen H, Li Z et al (2018) Differential spinal and supraspinal activation of glia in a rat model of morphine tolerance. Neuroscience 375:10\u201324","journal-title":"Neuroscience"},{"key":"1226_CR21","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0304-3959(96)03068-0","volume":"66","author":"SA Kanaan","year":"1996","unstructured":"Kanaan SA, Saade NE, Haddad JJ, Abdelnoor AM, Atweh SF, Jabbur SJ et al (1996) Endotoxin-induced local inflammation and hyperalgesia in rats, a new model for inflammatory pain. Pain 66:373\u2013379","journal-title":"Pain"},{"issue":"2","key":"1226_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/med.20182","volume":"31","author":"MN Khan","year":"2011","unstructured":"Khan MN, Lee YS (2011) Cyclooxygenase inhibitors: scope of their use and development in cancer chemotherapy. Med Res Rev 31(2):161\u2013201","journal-title":"Med Res Rev"},{"key":"1226_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fnmol.2016.00080","volume":"9","author":"Z-Z Kou","year":"2016","unstructured":"Kou Z-Z, Wan F-P, Bai Y, Li CY, Hu JC, Zhang GT et al (2016) Decreased endomorphin-2 and mu-opioid receptor in the spinal cord are associated with painful diabetic neuropathy. Front Mol Neurosci 9:80","journal-title":"Front Mol Neurosci"},{"key":"1226_CR24","unstructured":"Kruger NJ, Handbook (1994)Humana Press, New Jerseyp\u00a015\u201322"},{"key":"1226_CR25","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1080\/10715760310001616005","volume":"37","author":"O Kutuk","year":"2003","unstructured":"Kutuk O, Basaga H (2003) Aspirin prevents apoptosis and NF-kappaB activation induced by H2O2 in HeLa cells. Free Radic Res 37:1267\u20131276","journal-title":"Free Radic Res"},{"key":"1226_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ejphar.2009.03.049","volume":"612","author":"Q Li","year":"2009","unstructured":"Li Q, Zhao X, Zhong LJ, Yang HY, Wang Q, Pu XP (2009) Effects of chronic morphine treatment on protein expression in rat dorsal root ganglia. Eur J Pharmacol 612:21\u201328","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"1226_CR27","first-page":"416","volume":"41","author":"AS Mahajan","year":"1997","unstructured":"Mahajan AS, Chakrabarty K, Mishra TK, Chakrabarty AS (1997) Nociception, antinociceptive potency of morphine in streptozotocin induced diabetic rats. Indian J Physiol Pharmacol 41(4):416\u2013420","journal-title":"Indian J Physiol Pharmacol"},{"key":"1226_CR28","doi-asserted-by":"publisher","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","volume":"22","author":"J Mao","year":"2002","unstructured":"Mao J, Sung B, Ji RR, Lim G (2002) Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci 22:7650\u20137661","journal-title":"J Neurosci"},{"key":"1226_CR29","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.phrs.2015.04.014","volume":"97","author":"A Micov","year":"2015","unstructured":"Micov A, Tomi\u0107 M, Pecikoza U, Ugre\u0161i\u0107 N, Stepanovi\u0107-Petrovi\u0107 R (2015) Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy. Pharmacol Res 97:131\u2013142","journal-title":"Pharmacol Res"},{"key":"1226_CR30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejphar.2009.09.030","volume":"623","author":"J Mika","year":"2009","unstructured":"Mika J, Osikowicz M, Rojewska E, Korostynski M, Wawrzczak-Bargiela A, Przewlocki R, Przewlocka B (2009) Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain. Eur J Pharmacol 623:65\u201372","journal-title":"Eur J Pharmacol"},{"key":"1226_CR31","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.2337\/db12-0590","volume":"62","author":"SA Mousa","year":"2013","unstructured":"Mousa SA, Shaqura M, Khalefa BI, Z\u00f6llner C, Schaad L, Schneider J et al (2013) Rab7 silencing prevents \u00b5-opioid receptor lysosomal targeting and rescues opioid responsiveness to strengthen diabetic neuropathic pain therapy. Diabetes 62:1308\u20131319","journal-title":"Diabetes"},{"key":"1226_CR32","doi-asserted-by":"publisher","first-page":"174007","DOI":"10.1016\/j.ejphar.2021.174007","volume":"899","author":"KH Muchhala","year":"2021","unstructured":"Muchhala KH, Jacob JC, Dewey WL, Akbarali HI (2021) Role of \u03b2-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia. Eur J Pharmacol 899:174007","journal-title":"Eur J Pharmacol"},{"key":"1226_CR33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.pain.2007.03.022","volume":"132","author":"CK Nielsen","year":"2007","unstructured":"Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT (2007) Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain 132:289\u2013300","journal-title":"Pain"},{"key":"1226_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0014-2999(00)00408-8","volume":"401","author":"M Ohsawa","year":"2000","unstructured":"Ohsawa M, Mizoguchi H, Narita M, Kamei J, Nagase H, Tseng LF (2000) Effects of a mu-opioid receptor agonist on G-protein activation in streptozotocin-induced diabetic mice. Eur J Pharmacol 401:55\u201358","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"1226_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1139\/Y10-109","volume":"89","author":"E Ozdemir","year":"2011","unstructured":"Ozdemir E, Bagcivan I, Durmus N, Altun A, Gursoy S (2011) The nitric oxide\u2013cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine. Can J Physiol Pharmacol 89(2):89\u201395","journal-title":"Can J Physiol Pharmacol"},{"issue":"Suppl 1","key":"1226_CR36","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/j.diabres.2003.12.009","volume":"66","author":"TS Park","year":"2004","unstructured":"Park TS, Park JH, Baek HS (2004) Can diabetic neuropathy be prevented? Diabetes Res Clin Pract 66(Suppl 1):S53\u201356","journal-title":"Diabetes Res Clin Pract"},{"issue":"11","key":"1226_CR37","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.3390\/ph14111091","volume":"14","author":"AK Paul","year":"2021","unstructured":"Paul AK, Smith CM, Rahmatullah M, Nissapatorn V, Wilairatana P, Spetea M et al (2021) Opioid analgesia and opioid-induced adverse effects: a review. Pharmaceuticals (Basel) 14(11):1091","journal-title":"Pharmaceuticals (Basel)"},{"key":"1226_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF00442244","volume":"97","author":"K Ramabadran","year":"1989","unstructured":"Ramabadran K, Bansinath M, Turndorf H, Puig MM (1989) The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice. Psychopharmacology 97:169\u2013174","journal-title":"Psychopharmacology"},{"issue":"5","key":"1226_CR39","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1037\/a0013628","volume":"16","author":"A Rosenblum","year":"2008","unstructured":"Rosenblum A, Marsch LA, Joseph H, Portenoy RK (2008) Opioids and the treatment of chronic pain: controversies, current status, and future directions. Exp Clin Psychopharmacol 16(5):405\u2013416","journal-title":"Exp Clin Psychopharmacol"},{"key":"1226_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2337\/diabetes.52.1.165","volume":"52","author":"AM Schmeichel","year":"2003","unstructured":"Schmeichel AM, Schmelzer JD, Low PA (2003) Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 52:165\u2013171","journal-title":"Diabetes"},{"key":"1226_CR41","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ejphar.2015.07.027","volume":"764","author":"A Shafie","year":"2015","unstructured":"Shafie A, Moradi F, Izadpanah E, Mokarizadeh A, Moloudi MR, Nikzaban M, Hassanzadeh K (2015) Neuroprotection of donepezil against morphine-induced apoptosisis mediated through toll-like receptors. Eur J Pharmacol 764:292\u2013297","journal-title":"Eur J Pharmacol"},{"key":"1226_CR42","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jpain.2013.01.776","volume":"14","author":"M Shaqura","year":"2013","unstructured":"Shaqura M, Khalefa BI, Shakibaei M, Winkler J, Al-Khrasani M, F\u00fcrst S et al (2013) Reduced number, G protein coupling, and antinociceptive efficacy of spinal mu-opioid receptors in diabetic rats are reversed by nerve growth factor. J Pain 14:720\u2013730","journal-title":"J Pain"},{"key":"1226_CR43","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1213\/ANE.0b013e3182025b15","volume":"112","author":"CH Shen","year":"2011","unstructured":"Shen CH, Tsai RY, Shih MS, Lin SL, Tai YH, Chien CC, Wong CS (2011) Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. Anesth Analg 112:454\u2013459","journal-title":"Anesth Analg"},{"issue":"3","key":"1226_CR44","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1002\/jcp.27125","volume":"234","author":"S Shirooie","year":"2019","unstructured":"Shirooie S, Sahebgharani M, Esmaeili J, Dehpour AR (2019) In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway. J Cell Physiol 234(3):3058\u20133066","journal-title":"J Cell Physiol"},{"key":"1226_CR45","doi-asserted-by":"publisher","first-page":"146623","DOI":"10.1016\/j.brainres.2019.146623","volume":"1729","author":"J Sun","year":"2020","unstructured":"Sun J, Chen SR, Pan HL (2020) \u00b5-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. Brain Res 1729:146623","journal-title":"Brain Res"},{"key":"1226_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-11-56","volume":"11","author":"Z Wang","year":"2014","unstructured":"Wang Z, Huang W, Zuo Z (2014) Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of notch 1 in rat. J Neuroinflammation 11:1\u201310","journal-title":"J Neuroinflammation"},{"key":"1226_CR46","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00221-015-4513-4","volume":"234","author":"Y Wang","year":"2016","unstructured":"Wang Y, Ni H, Zhang W, Wang X, Zhang H (2016) Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion. Exp Brain Res 234:1057\u20131065","journal-title":"Exp Brain Res"},{"key":"1226_CR48","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbi.2006.10.011","volume":"21","author":"LR Watkins","year":"2007","unstructured":"Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF (2007) Norman Cousins lecture. Glia as the \u201cbad guys\u201d: implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun 21:131\u2013146","journal-title":"Brain Behav Immun"},{"issue":"7","key":"1226_CR49","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/WNR.0000000000000969","volume":"29","author":"W Wei","year":"2018","unstructured":"Wei W, Shurui C, Zipeng Z, Hongliang D, Hongyu W, Yuanlong L (2018) Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2\/HO-1 signaling pathway. NeuroReport 29(7):524\u2013531","journal-title":"NeuroReport"},{"key":"1226_CR50","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1124\/pr.112.005942","volume":"65","author":"JT Williams","year":"2013","unstructured":"Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S et al (2013) Regulation of \u00b5-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev 65:223\u2013254","journal-title":"Pharmacol Rev"},{"key":"1226_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/721547","volume":"4","author":"N Zangiabadi","year":"2014","unstructured":"Zangiabadi N, Mohtashami H, Hojatipour M, Jafari M, Asadi-Shekaari M, Shabani M (2014) The effect of angipars on diabetic neuropathy in STZ-induced diabetic male rats: a study on behavioral, electrophysiological, sciatic histological and ultrastructural indices. Sci World J 4:1\u20138","journal-title":"Sci World J"},{"key":"1226_CR54","doi-asserted-by":"publisher","first-page":"9432965","DOI":"10.1155\/2019\/9432965","volume":"2019","author":"TJ Zhang","year":"2019","unstructured":"Zhang TJ, Qiu Y, Hua Z (2019) The emerging perspective of morphine tolerance: MicroRNAs. Pain Res Manag 2019:9432965","journal-title":"Pain Res Manag"},{"key":"1226_CR53","doi-asserted-by":"publisher","first-page":"135678","DOI":"10.1016\/j.neulet.2021.135678","volume":"747","author":"B Zhang","year":"2021","unstructured":"Zhang B, Wu L, Zhu Q, Dong Y, Sun L (2021) Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: the role of cortical N-methyl-D-aspartate receptors. Neurosci Lett 747:135678","journal-title":"Neurosci Lett"},{"key":"1226_CR56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jneuroim.2013.06.005","volume":"262","author":"M Zychowska","year":"2013","unstructured":"Zychowska M, Rojewska E, Kreiner G, Nalepa I, Przewlocka B, Mika J (2013) Minocycline influences the antiinflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy. J Neuroimmunol 262:35\u201345","journal-title":"J Neuroimmunol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-023-01226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-023-01226-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-023-01226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:45:55Z","timestamp":1689331555000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-023-01226-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1226"],"URL":"https:\/\/doi.org\/10.1007\/s11011-023-01226-2","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,6]]},"assertion":[{"value":"12 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocols were approved by the Animal Ethics Committee of Cumhuriyet University (Ethic no: 2019\/181). All animal housing and experiments were conducted in strict accordance with the institutional guidelines for care and use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing financial interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}