{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:21:40Z","timestamp":1783351300253,"version":"3.54.6"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"],"award-info":[{"award-number":["Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-024-01342-7","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T05:02:32Z","timestamp":1706850152000},"page":"577-587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-3499","authenticated-orcid":false,"given":"Amanda","family":"Pasqualotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-4670","authenticated-orcid":false,"given":"Vin\u00edcius","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-9407","authenticated-orcid":false,"given":"Felipe Mateus","family":"Pellenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-0908","authenticated-orcid":false,"given":"Artur Francisco Schumacher","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-6687","authenticated-orcid":false,"given":"Ida Vanessa Doederlein","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-2177","authenticated-orcid":false,"given":"Marina","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"1342_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","volume":"138","author":"SJ Allen","year":"2013","unstructured":"Allen SJ, Watson JJ, Shoemark DK et al (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138:155\u2013175. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.01.004","journal-title":"Pharmacol Ther"},{"key":"1342_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.brainresbull.2016.08.018","volume":"126","author":"T Arendt","year":"2016","unstructured":"Arendt T, Stieler JT, Holzer M (2016) Tau and tauopathies. Brain Res Bull 126:238\u2013292. https:\/\/doi.org\/10.1016\/j.brainresbull.2016.08.018","journal-title":"Brain Res Bull"},{"key":"1342_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00221-011-2861-2","volume":"217","author":"D Aydin","year":"2012","unstructured":"Aydin D, Weyer SW, M\u00fcller UC (2012) Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 217:423\u2013434. https:\/\/doi.org\/10.1007\/s00221-011-2861-2","journal-title":"Exp Brain Res"},{"key":"1342_CR4","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea G, Mlecnik B, Hackl H et al (2009) ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25:1091\u20131093. https:\/\/doi.org\/10.1093\/bioinformatics\/btp101","journal-title":"Bioinformatics"},{"key":"1342_CR5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.tins.2017.04.001","volume":"40","author":"HDE Booth","year":"2017","unstructured":"Booth HDE, Hirst WD, Wade-Martins R (2017) The role of astrocyte dysfunction in Parkinson\u2019s Disease Pathogenesis. Trends Neurosci 40:358\u2013370. https:\/\/doi.org\/10.1016\/j.tins.2017.04.001","journal-title":"Trends Neurosci"},{"key":"1342_CR6","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1093\/hmg\/ddu334","volume":"23","author":"J Bras","year":"2014","unstructured":"Bras J, Guerreiro R, Darwent L et al (2014) Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet 23:6139\u20136146. https:\/\/doi.org\/10.1093\/hmg\/ddu334","journal-title":"Hum Mol Genet"},{"key":"1342_CR7","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1289\/ehp.7567","volume":"113","author":"RC Brown","year":"2005","unstructured":"Brown RC, Lockwood AH, Sonawane BR (2005) Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect 113:1250\u20131256. https:\/\/doi.org\/10.1289\/ehp.7567","journal-title":"Environ Health Perspect"},{"key":"1342_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-015-0025-8","volume":"10","author":"ML Caillet-Boudin","year":"2015","unstructured":"Caillet-Boudin ML, Bu\u00e9e L, Sergeant N, Lefebvre B (2015) Regulation of human MAPT gene expression. Mol Neurodegener 10:1\u201314. https:\/\/doi.org\/10.1186\/s13024-015-0025-8","journal-title":"Mol Neurodegener"},{"key":"1342_CR9","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1007\/s00415-015-7870-9","volume":"262","author":"Y Chen","year":"2015","unstructured":"Chen Y, Cao B, Yang J et al (2015) Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson\u2019s disease and multiple system atrophy in a Chinese population. J Neurol 262:2478\u20132483. https:\/\/doi.org\/10.1007\/s00415-015-7870-9","journal-title":"J Neurol"},{"key":"1342_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41588-021-00785-3","volume":"53","author":"R Chia","year":"2021","unstructured":"Chia R, Sabir MS, Bandres-Ciga S et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53:294\u2013303. https:\/\/doi.org\/10.1038\/s41588-021-00785-3","journal-title":"Nat Genet"},{"key":"1342_CR11","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1007\/s12035-020-02232-6","volume":"58","author":"L Dai","year":"2021","unstructured":"Dai L, Zou L, Meng L et al (2021) Cholesterol metabolism in neurodegenerative diseases: Molecular mechanisms and therapeutic targets. Mol Neurobiol 58:2183\u20132201. https:\/\/doi.org\/10.1007\/s12035-020-02232-6","journal-title":"Mol Neurobiol"},{"key":"1342_CR12","doi-asserted-by":"crossref","unstructured":"Deutschl\u00e4nder AB, Ross OA, Dickson DW, Wszolek ZK (2018) Atypical parkinsonian syndromes: a general neurologist\u2019s perspective. Eur J Neurol","DOI":"10.1111\/ene.13412"},{"key":"1342_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/B978-0-323-98817-9.00015-6","volume":"196","author":"G Devi","year":"2023","unstructured":"Devi G (2023) The tauopathies. Handb Clin Neurol 196:251\u2013265. https:\/\/doi.org\/10.1016\/B978-0-323-98817-9.00015-6","journal-title":"Handb Clin Neurol"},{"key":"1342_CR14","doi-asserted-by":"publisher","unstructured":"Dickson DW, Bergeron C, Chin SS et al (2002) Office of rare diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 61. https:\/\/doi.org\/10.1093\/jnen\/61.11.935","DOI":"10.1093\/jnen\/61.11.935"},{"key":"1342_CR15","doi-asserted-by":"crossref","unstructured":"Dietschy JM, Turley SD (2004) Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res","DOI":"10.1194\/jlr.R400004-JLR200"},{"key":"1342_CR16","doi-asserted-by":"publisher","unstructured":"Diez-Fairen M, Alvarez Jerez P, Berghausen J, Bandres-Ciga S (2021) The Genetic Landscape of parkinsonism-related Dystonias and atypical parkinsonism-related syndromes. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22158100","DOI":"10.3390\/ijms22158100"},{"key":"1342_CR17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s40478-014-0150-6","volume":"2","author":"AS Don","year":"2014","unstructured":"Don AS, Hsiao J-HT, Bleasel JM et al (2014) Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathol Commun 2:150. https:\/\/doi.org\/10.1186\/s40478-014-0150-6","journal-title":"Acta Neuropathol Commun"},{"key":"1342_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/B978-0-444-64012-3.00009-5","volume":"165","author":"G Fabbrini","year":"2019","unstructured":"Fabbrini G, Fabbrini A, Suppa A (2019) Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration. Handb Clin Neurol 165:155\u2013177. https:\/\/doi.org\/10.1016\/B978-0-444-64012-3.00009-5","journal-title":"Handb Clin Neurol"},{"key":"1342_CR19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s12035-012-8340-3","volume":"47","author":"L Fellner","year":"2013","unstructured":"Fellner L, Stefanova N (2013) The role of glia in \u03b1-synucleinopathies. Mol Neurobiol 47:575\u2013586. https:\/\/doi.org\/10.1007\/s12035-012-8340-3","journal-title":"Mol Neurobiol"},{"key":"1342_CR20","doi-asserted-by":"crossref","unstructured":"Foguem C, Manckoundia P (2018) Lewy Body Disease: clinical and pathological overlap syndrome between synucleinopathies (Parkinson Disease) and tauopathies (Alzheimer Disease). Curr Neurol Neurosci Rep 18","DOI":"10.1007\/s11910-018-0835-5"},{"key":"1342_CR21","doi-asserted-by":"crossref","unstructured":"Giagkou N, Stamelou M (2018) Therapeutic management of the overlapping syndromes of atypical parkinsonism. CNS Drugs","DOI":"10.1007\/s40263-018-0551-3"},{"key":"1342_CR22","doi-asserted-by":"publisher","first-page":"D322","DOI":"10.1093\/nar\/gkj021","volume":"34","author":"MA Harris","year":"2006","unstructured":"Harris MA, Clark JI, Ireland A et al (2006) The gene ontology (GO) project in 2006. Nucleic Acids Res 34:D322\u2013D326. https:\/\/doi.org\/10.1093\/nar\/gkj021","journal-title":"Nucleic Acids Res"},{"key":"1342_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-015-0611-3","volume":"16","author":"H Heberle","year":"2015","unstructured":"Heberle H, Meirelles VG, da Silva FR et al (2015) InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinformatics 16:1\u20137. https:\/\/doi.org\/10.1186\/s12859-015-0611-3","journal-title":"BMC Bioinformatics"},{"key":"1342_CR24","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1002\/mds.27773","volume":"34","author":"MG Heckman","year":"2019","unstructured":"Heckman MG, Kasanuki K, Brennan RR et al (2019) Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease. Mov Disord 34:1325\u20131332. https:\/\/doi.org\/10.1002\/mds.27773","journal-title":"Mov Disord"},{"key":"1342_CR25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/ng.859","volume":"43","author":"GU H\u00f6glinger","year":"2011","unstructured":"H\u00f6glinger GU, Melhem NM, Dickson DW et al (2011) Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet 43:699\u2013705. https:\/\/doi.org\/10.1038\/ng.859","journal-title":"Nat Genet"},{"key":"1342_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987","author":"GU H\u00f6glinger","year":"2017","unstructured":"H\u00f6glinger GU, Respondek G, Stamelou M et al (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. https:\/\/doi.org\/10.1002\/mds.26987","journal-title":"Mov Disord"},{"key":"1342_CR27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/mds.870130116","volume":"13","author":"B Holmberg","year":"1998","unstructured":"Holmberg B, Rosengren L, Karlsson J-E, Johnels B (1998) Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson\u2019s disease. Mov Disord 13:70\u201377. https:\/\/doi.org\/10.1002\/mds.870130116","journal-title":"Mov Disord"},{"key":"1342_CR28","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3233\/JAD-170397","volume":"62","author":"KA Jellinger","year":"2018","unstructured":"Jellinger KA (2018) Multiple system atrophy: an oligodendroglioneural Synucleinopathy1. J Alzheimers Dis 62:1141\u20131179. https:\/\/doi.org\/10.3233\/JAD-170397","journal-title":"J Alzheimers Dis"},{"key":"1342_CR29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00702-016-1545-2","volume":"123","author":"KA Jellinger","year":"2016","unstructured":"Jellinger KA, Wenning GK (2016) Multiple system atrophy: pathogenic mechanisms and biomarkers. J Neural Transm (Vienna) 123:555\u2013572. https:\/\/doi.org\/10.1007\/s00702-016-1545-2","journal-title":"J Neural Transm (Vienna)"},{"key":"1342_CR30","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","volume":"1802","author":"EK Kim","year":"2010","unstructured":"Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta Mol Basis Dis 1802:396\u2013405. https:\/\/doi.org\/10.1016\/j.bbadis.2009.12.009","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1342_CR31","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12272-011-0518-0","volume":"34","author":"SS Kim","year":"2011","unstructured":"Kim SS, Moon KR, Choi HJ (2011) Interference of alpha-synuclein with cAMP\/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells. Arch Pharm Res 34:837\u2013845. https:\/\/doi.org\/10.1007\/s12272-011-0518-0","journal-title":"Arch Pharm Res"},{"key":"1342_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms8247","volume":"6","author":"N Kouri","year":"2015","unstructured":"Kouri N, Ross OA, Dombroski B et al (2015) Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nat Commun 6:1\u20137. https:\/\/doi.org\/10.1038\/ncomms8247","journal-title":"Nat Commun"},{"key":"1342_CR33","doi-asserted-by":"crossref","unstructured":"Lill CM (2016) Genetics of Parkinson\u2019s disease. Mol Cell Probes","DOI":"10.1016\/j.mcp.2016.11.001"},{"key":"1342_CR35","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.1523\/JNEUROSCI.0618-11.2011","volume":"31","author":"Y Lim","year":"2011","unstructured":"Lim Y, Kehm VM, Lee EB et al (2011) \u0391-Syn suppression reverses synaptic and memory defects in a mouse model of Dementia with Lewy Bodies. J Neurosci 31:10076\u201310087. https:\/\/doi.org\/10.1523\/JNEUROSCI.0618-11.2011","journal-title":"J Neurosci"},{"key":"1342_CR34","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1007\/s00415-018-9100-8","volume":"266","author":"EW Lim","year":"2019","unstructured":"Lim EW, Aarsland D, Ffytche D et al (2019) Amyloid-\u03b2 and Parkinson\u2019s disease. J Neurol 266:2605\u20132619. https:\/\/doi.org\/10.1007\/s00415-018-9100-8","journal-title":"J Neurol"},{"key":"1342_CR37","doi-asserted-by":"publisher","unstructured":"McKeith IG, Boeve BF, Dickson DW et al (2017) Diagnosis and management of dementia with Lewy bodies. Neurology 89:88\u2013100. https:\/\/doi.org\/10.1212\/WNL.0000000000004058","DOI":"10.1212\/WNL.0000000000004058"},{"key":"1342_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"67","author":"J Melissa","year":"2013","unstructured":"Melissa J, Armstrong et al (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 67:513\u2013523. https:\/\/doi.org\/10.1212\/WNL.0b013e31827f0fd1.","journal-title":"Neurology"},{"key":"1342_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"Minoru Kanehisa and Susumu Goto","year":"2000","unstructured":"Minoru Kanehisa and Susumu Goto (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27\u201330","journal-title":"Nucleic Acids Res"},{"key":"1342_CR40","doi-asserted-by":"crossref","unstructured":"Miryala SK, Anbarasu A, Ramaiah S (2018) Discerning molecular interactions: A comprehensive review on biomolecular interaction databases and network analysis tools. Gene","DOI":"10.1016\/j.gene.2017.11.028"},{"key":"1342_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.185","author":"J Mitsui","year":"2015","unstructured":"Mitsui J, Matsukawa T, Sasaki H et al (2015) Variants associated with gaucher disease in multiple system atrophy. Ann Clin Transl Neurol. https:\/\/doi.org\/10.1002\/acn3.185","journal-title":"Ann Clin Transl Neurol"},{"key":"1342_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-016-0840-8","author":"E Pang","year":"2016","unstructured":"Pang E, Hao Y, Sun Y, Lin K (2016) Differential variation patterns between hubs and bottlenecks in human protein-protein interaction networks. BMC Evol Biol. https:\/\/doi.org\/10.1186\/s12862-016-0840-8","journal-title":"BMC Evol Biol"},{"key":"1342_CR43","doi-asserted-by":"publisher","first-page":"D833","DOI":"10.1093\/nar\/gkw943","volume":"45","author":"J Pi\u00f1ero","year":"2017","unstructured":"Pi\u00f1ero J, Bravo \u00c1, Queralt-Rosinach N et al (2017a) DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res 45:D833\u2013D839. https:\/\/doi.org\/10.1093\/nar\/gkw943","journal-title":"Nucleic Acids Res"},{"key":"1342_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw943","author":"J Pi\u00f1ero","year":"2017","unstructured":"Pi\u00f1ero J, Bravo \u00c1, Queralt-Rosinach N et al (2017b) DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkw943","journal-title":"Nucleic Acids Res"},{"key":"1342_CR45","doi-asserted-by":"publisher","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E et al (1997) Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease. Sci (1979) 276:2045\u20132047. https:\/\/doi.org\/10.1126\/science.276.5321.2045","DOI":"10.1126\/science.276.5321.2045"},{"key":"1342_CR46","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s00439-001-0615-0","volume":"109","author":"S Povey","year":"2001","unstructured":"Povey S, Lovering R, Bruford E et al (2001) The HUGO Gene Nomenclature Committee (HGNC). Hum Genet 109:678\u2013680. https:\/\/doi.org\/10.1007\/s00439-001-0615-0","journal-title":"Hum Genet"},{"key":"1342_CR47","doi-asserted-by":"publisher","first-page":"D419","DOI":"10.1093\/nar\/gkw1082","volume":"45","author":"S Rahmati","year":"2017","unstructured":"Rahmati S, Abovsky M, Pastrello C, Jurisica I (2017) PathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis. Nucleic Acids Res 45:D419\u2013D426. https:\/\/doi.org\/10.1093\/nar\/gkw1082","journal-title":"Nucleic Acids Res"},{"key":"1342_CR48","doi-asserted-by":"publisher","first-page":"101644","DOI":"10.1016\/j.pneurobio.2019.101644","volume":"180","author":"TW R\u00f6sler","year":"2019","unstructured":"R\u00f6sler TW, Tayaranian Marvian A, Brendel M et al (2019) Four-repeat tauopathies. Prog Neurobiol 180:101644. https:\/\/doi.org\/10.1016\/j.pneurobio.2019.101644","journal-title":"Prog Neurobiol"},{"key":"1342_CR49","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.nbd.2019.02.016","volume":"127","author":"MS Sabir","year":"2019","unstructured":"Sabir MS, Blauwendraat C, Ahmed S et al (2019) Assessment of APOE in atypical parkinsonism syndromes. Neurobiol Dis 127:142\u2013146. https:\/\/doi.org\/10.1016\/j.nbd.2019.02.016","journal-title":"Neurobiol Dis"},{"key":"1342_CR50","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cger.2018.06.007","volume":"34","author":"AM Sanford","year":"2018","unstructured":"Sanford AM (2018) Lewy Body Dementia. Clin Geriatr Med 34:603\u2013615. https:\/\/doi.org\/10.1016\/j.cger.2018.06.007","journal-title":"Clin Geriatr Med"},{"key":"1342_CR51","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/sj.mp.4000285","volume":"2","author":"A Sawa","year":"1997","unstructured":"Sawa A, Amano N, Yamada N et al (1997) Apolipoprotein E in progressive supranuclear palsy in Japan. Mol Psychiatry 2:341\u2013342. https:\/\/doi.org\/10.1038\/sj.mp.4000285","journal-title":"Mol Psychiatry"},{"key":"1342_CR52","doi-asserted-by":"crossref","unstructured":"Scholz SW, Bras J (2015) Genetics underlying atypical parkinsonism and related neurodegenerative disorders. Int J Mol Sci","DOI":"10.3390\/ijms161024629"},{"key":"1342_CR53","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/ana.21685","volume":"65","author":"SW Scholz","year":"2009","unstructured":"Scholz SW, Houlden H, Schulte C et al (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol 65:610\u2013614. https:\/\/doi.org\/10.1002\/ana.21685","journal-title":"Ann Neurol"},{"key":"1342_CR54","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","volume":"20","author":"A Serrano-Pozo","year":"2021","unstructured":"Serrano-Pozo A, Das S, Hyman BT (2021) APOE and Alzheimer\u2019s disease: advances in genetics, pathophysiology, and therapeutic approaches. Lancet Neurol 20:68\u201380. https:\/\/doi.org\/10.1016\/S1474-4422(20)30412-9","journal-title":"Lancet Neurol"},{"key":"1342_CR55","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O et al (2003) Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"1342_CR56","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901281","author":"E Sidransky","year":"2009","unstructured":"Sidransky E, Nalls MA, Aasly JO et al (2009) Multicenter Analysis of glucocerebrosidase mutations in Parkinson\u2019s Disease. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa0901281","journal-title":"N Engl J Med"},{"key":"1342_CR57","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41582-021-00541-5","volume":"17","author":"M Stamelou","year":"2021","unstructured":"Stamelou M, Respondek G, Giagkou N et al (2021) Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies. Nat Rev Neurol 17:601\u2013620. https:\/\/doi.org\/10.1038\/s41582-021-00541-5","journal-title":"Nat Rev Neurol"},{"key":"1342_CR58","doi-asserted-by":"publisher","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","volume":"2","author":"L Stefanis","year":"2012","unstructured":"Stefanis L (2012) \u03b1-Synuclein in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2:a009399. https:\/\/doi.org\/10.1101\/cshperspect.a009399","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1342_CR59","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1002\/mds.21671","volume":"22","author":"N Stefanova","year":"2007","unstructured":"Stefanova N, Reindl M, Neumann M et al (2007) Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy. Mov Disord 22:2196\u20132203. https:\/\/doi.org\/10.1002\/mds.21671","journal-title":"Mov Disord"},{"key":"1342_CR60","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41374-019-0197-x","volume":"99","author":"KH Strang","year":"2019","unstructured":"Strang KH, Golde TE, Giasson BI (2019) MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Lab Invest 99:912\u2013928. https:\/\/doi.org\/10.1038\/s41374-019-0197-x","journal-title":"Lab Invest"},{"key":"1342_CR61","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D et al (2019) STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res 47:D607\u2013D613. https:\/\/doi.org\/10.1093\/nar\/gky1131","journal-title":"Nucleic Acids Res"},{"key":"1342_CR62","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1042\/EBC20180003","volume":"62","author":"I Tavassoly","year":"2018","unstructured":"Tavassoly I, Goldfarb J, Iyengar R (2018) Systems biology primer: the basic methods and approaches. Essays Biochem 62:487\u2013500. https:\/\/doi.org\/10.1042\/EBC20180003","journal-title":"Essays Biochem"},{"key":"1342_CR63","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1002\/jnr.22089","volume":"87","author":"K Ubhi","year":"2009","unstructured":"Ubhi K, Lee PH, Adame A et al (2009) Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res 87:2728\u20132739. https:\/\/doi.org\/10.1002\/jnr.22089","journal-title":"J Neurosci Res"},{"key":"1342_CR64","doi-asserted-by":"crossref","unstructured":"Vance JE (2012) Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases. DMM Disease Models and Mechanisms","DOI":"10.1242\/dmm.010124"},{"key":"1342_CR65","doi-asserted-by":"crossref","unstructured":"Vidal M (2009) A unifying view of 21st century systems biology. FEBS Lett","DOI":"10.1016\/j.febslet.2009.11.024"},{"key":"1342_CR66","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/mds.29005","volume":"37","author":"GK Wenning","year":"2022","unstructured":"Wenning GK, Stankovic I, Vignatelli L et al (2022) The Movement Disorder Society Criteria for the diagnosis of multiple system atrophy. Mov Disord 37:1131\u20131148","journal-title":"Mov Disord"},{"key":"1342_CR67","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.neurobiolaging.2014.10.042","volume":"36","author":"W Xu","year":"2015","unstructured":"Xu W, Tan L, Yu JT (2015) The link between the SNCA gene and parkinsonism. Neurobiol Aging 36:1505\u20131518. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.10.042","journal-title":"Neurobiol Aging"},{"key":"1342_CR68","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1038\/s41467-018-06783-0","volume":"9","author":"N Zhao","year":"2018","unstructured":"Zhao N, Liu C-C, Van Ingelgom AJ et al (2018) APOE \u03b52 is associated with increased tau pathology in primary tauopathy. Nat Commun 9:4388. https:\/\/doi.org\/10.1038\/s41467-018-06783-0","journal-title":"Nat Commun"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-024-01342-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-024-01342-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-024-01342-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T23:32:45Z","timestamp":1713742365000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-024-01342-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":67,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["1342"],"URL":"https:\/\/doi.org\/10.1007\/s11011-024-01342-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3015470\/v1","asserted-by":"object"}]},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"6 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involves only public domain data that does not identify the participants, so no ethical approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"All authors certify that they have no involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}