{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:30Z","timestamp":1788922170173,"version":"build-2803163510"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-024-01452-2","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:05:22Z","timestamp":1734595522000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emerging role of Nrf2 in Parkinson\u2019s disease therapy: a critical reassessment"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6061-2012","authenticated-orcid":false,"given":"Veerta","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3656-669X","authenticated-orcid":false,"given":"Prateek","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"5","key":"1452_CR1","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/jnc.13087","volume":"133","author":"RM Abdelsalam","year":"2015","unstructured":"Abdelsalam RM, Safar MM (2015) Neuroprotective effects of vildagliptin in rat rotenone Parkinson\u2019s disease model: role of RAGE-NF \u03baB and Nrf2\u2010antioxidant signaling pathways. J Neurochem 133(5):700\u2013707. https:\/\/doi.org\/10.1111\/jnc.13087","journal-title":"J Neurochem"},{"key":"1452_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3389\/fncel.2015.00209","volume":"9","author":"B Alural","year":"2015","unstructured":"Alural B, Ozerdem A, Allmer J, Genc K, Genc S (2015) Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells. Front Cell Neurosci 9:209","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"1452_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JPD-140491","volume":"5","author":"HE Allen Reish","year":"2015","unstructured":"Allen Reish HE, Standaert DG (2015) Role of \u03b1-synuclein in inducing innate and adaptive immunity in Parkinson disease. Journal of Parkinson\u2019s disease 5(1):1\u20139","journal-title":"Journal of Parkinson's disease"},{"key":"1452_CR4","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12640-020-00213-0","volume":"38","author":"E Anis","year":"2020","unstructured":"Anis E, Zafeer MF, Firdaus F, Islam SN, Khan AA, Hossain MM (2020) Perillyl alcohol mitigates behavioural changes and limits cell death and mitochondrial changes in unilateral 6-OHDA lesion model of Parkinson\u2019s disease through alleviation of oxidative stress. Neurotox Res 38:461\u2013477","journal-title":"Neurotox Res"},{"issue":"4","key":"1452_CR5","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1021\/acschemneuro.0c00722","volume":"12","author":"HH Arab","year":"2021","unstructured":"Arab HH, Safar MM, Shahin NN (2021) Targeting ROS-dependent Akt\/GSK-3\u03b2\/NF-\u03baB and DJ-1\/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced Parkinson\u2019s disease rat model. ACS Chem Neurosci 12(4):689\u2013703","journal-title":"ACS Chem Neurosci"},{"issue":"7","key":"1452_CR6","doi-asserted-by":"publisher","first-page":"6868","DOI":"10.3390\/cimb46070410","volume":"46","author":"F Armeli","year":"2024","unstructured":"Armeli F, Mengoni B, Laskin DL, Businaro R (2024) Interplay among oxidative stress, Autophagy, and the Endocannabinoid System in neurodegenerative diseases: role of the Nrf2-p62\/SQSTM1 pathway and nutraceutical activation. Curr Issues Mol Biol 46(7):6868","journal-title":"Curr Issues Mol Biol"},{"issue":"8","key":"1452_CR7","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1080\/1028415X.2021.1892985","volume":"25","author":"VK Arruri","year":"2022","unstructured":"Arruri VK, Gundu C, Kalvala AK, Sherkhane B, Khatri DK, Singh SB (2022) Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1\/Nrf-2\/p62 directed autophagy and mitochondrial quality control in neuropathic pain. Nutr Neurosci 25(8):1731\u20131746","journal-title":"Nutr Neurosci"},{"issue":"7","key":"1452_CR8","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/ars.2011.4429","volume":"18","author":"EJ Bae","year":"2013","unstructured":"Bae EJ, Ho DH, Park E, Jung JW, Cho K, Hong JH, Lee HJ, Kim KP, Lee SJ (2013) Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of \u03b1-synuclein. Antioxid Redox Signal 18(7):770\u2013783. https:\/\/doi.org\/10.1089\/ars.2011.4429","journal-title":"Antioxid Redox Signal"},{"key":"1452_CR9","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.taap.2017.08.012","volume":"333","author":"J Bai","year":"2017","unstructured":"Bai J, Yu XJ, Liu KL, Wang FF, Jing GX, Li HB, Zhang Y, Huo CJ, Li X, Gao HL, Qi J (2017) Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats. Toxicol Appl Pharmcol 333:100\u2013109","journal-title":"Toxicol Appl Pharmcol"},{"key":"1452_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.brainres.2017.02.021","volume":"1662","author":"T Baluchnejadmojarad","year":"2017","unstructured":"Baluchnejadmojarad T, Rabiee N, Zabihnejad S, Roghani M (2017) Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson\u2019s disease: possible involvement of ER\u03b2\/Nrf2\/HO-1 signaling. Brain Res 1662:23\u201330","journal-title":"Brain Res"},{"issue":"6","key":"1452_CR11","first-page":"4890","volume":"19","author":"B Bao","year":"2019","unstructured":"Bao B, Zhang MQ, Chen ZY, Wu XB, Xia ZB, Chai JY, Yin XP (2019) Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway. Mol Med Rep 19(6):4890\u20134896","journal-title":"Mol Med Rep"},{"key":"1452_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40035-020-00226-x","volume":"10","author":"T Behl","year":"2021","unstructured":"Behl T, Kaur G, Fratila O, Buhas C, Judea-Pusta CT, Negrut N, Bustea C, Bungau S (2021a) Cross-talks among GBA mutations, glucocerebrosidase, and \u03b1-synuclein in GBA-associated Parkinson\u2019s disease and their targeted therapeutic approaches: a comprehensive review. Translational Neurodegeneration 10:1\u20133","journal-title":"Translational Neurodegeneration"},{"issue":"3","key":"1452_CR13","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.3390\/ijms22031413","volume":"22","author":"T Behl","year":"2021","unstructured":"Behl T, Kaur G, Sehgal A, Bhardwaj S, Singh S, Buhas C, Judea-Pusta C, Uivarosan D, Munteanu MA, Bungau S (2021b) Multifaceted role of matrix metalloproteinases in neurodegenerative diseases: pathophysiological and therapeutic perspectives. Int J Mol Sci 22(3):1413","journal-title":"Int J Mol Sci"},{"key":"1452_CR14","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.neubiorev.2020.10.004","volume":"120","author":"G Bj\u00f8rklund","year":"2021","unstructured":"Bj\u00f8rklund G, Peana M, Maes M, Dadar M, Severin B (2021) The glutathione system in Parkinson\u2019s disease and its progression. Neurosci Biobehavioral Reviews 120:470\u2013478","journal-title":"Neurosci Biobehavioral Reviews"},{"issue":"2","key":"1452_CR15","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11011-021-00879-1","volume":"37","author":"B Cao","year":"2022","unstructured":"Cao B, Zhang Y, Chen J, Wu P, Dong Y, Wang Y (2022) Neuroprotective effects of liraglutide against inflammation through the AMPK\/NF-\u03baB pathway in a mouse model of Parkinson\u2019s disease. Metab Brain Dis 37(2):451\u2013462. https:\/\/doi.org\/10.1007\/s11011-021-00879-1","journal-title":"Metab Brain Dis"},{"key":"1452_CR16","doi-asserted-by":"publisher","first-page":"105325","DOI":"10.1016\/j.neuint.2022.105325","volume":"156","author":"A Chakkittukandiyil","year":"2022","unstructured":"Chakkittukandiyil A, Sajini DV, Karuppaiah A, Selvaraj D (2022) The principal molecular mechanisms behind the activation of Keap1\/Nrf2\/ARE pathway leading to neuroprotective action in Parkinson\u2019s disease. Neurochem Int 156:105325","journal-title":"Neurochem Int"},{"issue":"9","key":"1452_CR17","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1021\/tx300171u","volume":"25","author":"JH Chen","year":"2012","unstructured":"Chen JH, Ou HP, Lin CY, Lin FJ, Wu CR, Chang SW, Tsai CW (2012) Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis. Chem Res Toxicol 25(9):1893\u20131901","journal-title":"Chem Res Toxicol"},{"key":"1452_CR18","doi-asserted-by":"publisher","first-page":"112866","DOI":"10.1016\/j.biopha.2022.112866","volume":"149","author":"J Chen","year":"2022","unstructured":"Chen J, Xu J, Huang P, Luo Y, Shi Y, Ma P (2022) The potential applications of traditional Chinese medicine in Parkinson\u2019s disease: a new opportunity. Biomed Pharmacother 149:112866","journal-title":"Biomed Pharmacother"},{"key":"1452_CR19","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3389\/fphar.2018.01444","volume":"9","author":"JH Choi","year":"2018","unstructured":"Choi JH, Jang M, Lee JI, Chung WS, Cho IH (2018) Neuroprotective effects of a traditional multi-herbal medicine kyung-ok-ko in an animal model of Parkinson\u2019s disease: inhibition of MAPKs and NF-\u03baB pathways and activation of keap1-Nrf2 pathway. Front Pharmacol 9:1444","journal-title":"Front Pharmacol"},{"issue":"14","key":"1452_CR20","doi-asserted-by":"publisher","first-page":"7952","DOI":"10.3390\/ijms25147952","volume":"25","author":"EH Choi","year":"2024","unstructured":"Choi EH, Kim MH, Park SJ (2024) Targeting mitochondrial dysfunction and reactive oxygen species for neurodegenerative Disease treatment. Int J Mol Sci 25(14):7952","journal-title":"Int J Mol Sci"},{"key":"1452_CR21","doi-asserted-by":"crossref","unstructured":"Coukos R, Krainc D (2024) Key genes and convergent pathogenic mechanisms in Parkinson disease. Nat Reviews Neurosci 25(6), 393\u2013413.","DOI":"10.1038\/s41583-024-00812-2"},{"issue":"3","key":"1452_CR22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1517\/13543780802716501","volume":"13","author":"A Cuadrado","year":"2009","unstructured":"Cuadrado A, Moreno-Murciano P, Pedraza-Chaverri J (2009) The transcription factor Nrf2 as a new therapeutic target in Parkinson\u2019s disease. Expert Opin Ther Targets 13(3):319\u2013329","journal-title":"Expert Opin Ther Targets"},{"issue":"2","key":"1452_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/pr.117.014753","volume":"70","author":"A Cuadrado","year":"2018","unstructured":"Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, Le\u00f3n R, L\u00f3pez MG, Oliva B, Pajares M (2018) Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach. Pharmacol Rev 70(2):348\u2013383","journal-title":"Pharmacol Rev"},{"issue":"2","key":"1452_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3233\/JPD-171296","volume":"8","author":"DW Curry","year":"2018","unstructured":"Curry DW, Stutz B, Andrews ZB, Elsworth JD (2018) Targeting AMPK signaling as a neuroprotective strategy in Parkinson\u2019s disease. J Parkinson\u2019s Disease 8(2):161\u2013181","journal-title":"J Parkinson\u2019s Disease"},{"key":"1452_CR25","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pestbp.2019.03.017","volume":"157","author":"RG dos Santos Nunes","year":"2019","unstructured":"dos Santos Nunes RG, Pereira PS, Elekofehinti OO, Fidelis KR, da Silva CS, Ibrahim M, Barros LM, da Cunha FA, Lukong KE, de Menezes IR, Tsopmo A (2019) Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster. Pestic Biochem Physiol 157:161\u2013168","journal-title":"Pestic Biochem Physiol"},{"key":"1452_CR26","doi-asserted-by":"publisher","first-page":"100942","DOI":"10.1016\/j.arr.2019.100942","volume":"54","author":"L F\u00e3o","year":"2019","unstructured":"F\u00e3o L, Mota SI, Rego AC (2019) Shaping the Nrf2-ARE-related pathways in Alzheimer\u2019s and Parkinson\u2019s diseases. Ageing Res Rev 54:100942","journal-title":"Ageing Res Rev"},{"key":"1452_CR27","doi-asserted-by":"publisher","unstructured":"Fukutomi T, Takagi K, Mizushima T, Ohuchi N, Yamamoto M (2014) Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. Molecular and cellular biology. 34(5):832\u2013846. https:\/\/doi.org\/10.1128\/MCB.01191-13","DOI":"10.1128\/MCB.01191-13"},{"key":"1452_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cbi.2016.03.023","volume":"251","author":"HH Gaballah","year":"2016","unstructured":"Gaballah HH, Zakaria SS, Elbatsh MM, Tahoon NM (2016) Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson\u2019s disease. Chemico-Biol Interact 251:10\u201316","journal-title":"Chemico-Biol Interact"},{"issue":"21","key":"1452_CR29","doi-asserted-by":"publisher","first-page":"9424","DOI":"10.18632\/aging.102394","volume":"11","author":"C Guo","year":"2019","unstructured":"Guo C, Zhu J, Wang J, Duan J, Ma S, Yin Y, Quan W, Zhang W, Guan Y, Ding Y, Wen A (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2\/p-GSK3\u03b2\/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson\u2019s disease. Aging 11(21):9424","journal-title":"Aging"},{"key":"1452_CR30","doi-asserted-by":"crossref","unstructured":"Hao S, Cho BO, Wang F, Shin JY, Shin DJ, Jang SI (2022) Zingiber officinale attenuates 6-hydroxydopamine induced oxidative stress and apoptosis through AKT, Nrf2, MAPK, NF-\u03baB signaling pathway in PC12 cells. Food Sci Technol. 42,: e11122142.","DOI":"10.1590\/fst.111221"},{"issue":"1","key":"1452_CR31","doi-asserted-by":"publisher","first-page":"fcad356","DOI":"10.1093\/braincomms\/fcad356","volume":"6","author":"A Houldsworth","year":"2024","unstructured":"Houldsworth A (2024) Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants. Brain Commun 6(1):fcad356","journal-title":"Brain Commun"},{"issue":"3","key":"1452_CR32","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/1440-1681.12344","volume":"42","author":"LP Huang","year":"2015","unstructured":"Huang LP, Deng MZ, He YP, Fang YQ (2015) \u03b2-asarone and levodopa co\u2010administration protects against 6\u2010hydroxydopamine\u2010induced damage in parkinsonian rat mesencephalon by regulating autophagy: down\u2010expression Beclin\u20101 and light chain 3B and up\u2010expression P62. Clin Exp Pharmacol Physiol 42(3):269\u2013277. https:\/\/doi.org\/10.1111\/1440-1681.12344","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"1452_CR33","first-page":"123","volume":"4","author":"OE Ifeanyi","year":"2018","unstructured":"Ifeanyi OE (2018) A review on free radicals and antioxidants. Int J Curr Res Med Sci 4(2):123\u2013133","journal-title":"Int J Curr Res Med Sci"},{"issue":"6","key":"1452_CR34","doi-asserted-by":"publisher","first-page":"581","DOI":"10.4062\/biomolther.2016.141","volume":"24","author":"YH Jeong","year":"2016","unstructured":"Jeong YH, Park JS, Kim DH, Kim HS (2016) Lonchocarpine increases Nrf2\/ARE-mediated antioxidant enzyme expression by modulating AMPK and MAPK signaling in brain astrocytes. Biomolecules Ther 24(6):581","journal-title":"Biomolecules Ther"},{"key":"1452_CR35","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10068-018-0477-z","volume":"28","author":"HL Jung","year":"2019","unstructured":"Jung HL, Yang SY, Pyo MC, Hong CO, Nam MH, Lee JW, Lee KW (2019) Protective effects of chebulic acid from Terminalia chebula Retz against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. Food science and biotechnology 28:555\u201362","journal-title":"Food science and biotechnology"},{"issue":"28","key":"1452_CR36","doi-asserted-by":"publisher","first-page":"37060","DOI":"10.1007\/s11356-021-14619-6","volume":"28","author":"I Kaur","year":"2021","unstructured":"Kaur I, Behl T, Sehgal A, Singh S, Sharma N, Aleya L, Bungau S (2021) Connecting the dots between mitochondrial dysfunction and Parkinson\u2019s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity. Environ Sci Pollut Res 28(28):37060\u201337081. https:\/\/doi.org\/10.1007\/s11356-021-14619-6","journal-title":"Environ Sci Pollut Res"},{"key":"1452_CR37","doi-asserted-by":"crossref","unstructured":"Kaur T, Sidana P, Kaur N, Choubey V, Kaasik A (2024) Unraveling neuroprotection in Parkinson\u2019s disease: Nrf2\u2013Keap1 pathway\u2019s vital role amidst pathogenic pathways. Inflammopharmacology 32(5) 2801\u20132820.","DOI":"10.1007\/s10787-024-01549-1"},{"key":"1452_CR38","doi-asserted-by":"publisher","first-page":"115496","DOI":"10.1016\/j.bcp.2023.115496","volume":"210","author":"SS Khan","year":"2023","unstructured":"Khan SS, Janrao S, Srivastava S, Singh SB, Vora L, Khatri DK (2023) GSK-3\u03b2: an exuberating neuroinflammatory mediator in Parkinson\u2019s disease. Biochem Pharmacol 210:115496","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"1452_CR39","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1111\/1750-3841.14643","volume":"84","author":"J Kim","year":"2019","unstructured":"Kim J, Oh J, Averilla JN, Kim HJ, Kim JS, Kim JS (2019) Grape peel extract and resveratrol inhibit wrinkle formation in mice model through activation of Nrf2\/HO-1 signaling pathway. J Food Sci 84(6):1600\u20131608","journal-title":"J Food Sci"},{"issue":"11","key":"1452_CR40","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.2174\/1389450110607011377","volume":"7","author":"L Kockeritz","year":"2006","unstructured":"Kockeritz L, Doble B, Patel S, Woodgett JR (2006) Glycogen synthase kinase-3-an overview of an over-achieving protein kinase. Curr Drug Targets 7(11):1377\u20131388","journal-title":"Curr Drug Targets"},{"key":"1452_CR41","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.jff.2015.10.010","volume":"19","author":"X Kou","year":"2015","unstructured":"Kou X, Li J, Bian J, Yang Y, Yang X, Fan J, Jia S, Chen N (2015) Ampelopsin attenuates 6-OHDA-induced neurotoxicity by regulating GSK-3\u03b2\/NRF2\/ARE signalling. J Funct Foods 19:765\u2013774. https:\/\/doi.org\/10.1016\/j.jff.2015.10.010","journal-title":"J Funct Foods"},{"issue":"20","key":"1452_CR42","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.2174\/0929867325666181009161048","volume":"26","author":"N Kustrimovic","year":"2019","unstructured":"Kustrimovic N, Marino F, Cosentino M (2019) Peripheral immunity, immunoaging and neuroinflammation in Parkinson\u2019s disease. Curr Med Chem 26(20):3719\u20133753. https:\/\/doi.org\/10.2174\/0929867325666181009161048","journal-title":"Curr Med Chem"},{"issue":"10","key":"1452_CR43","first-page":"702","volume":"42","author":"JA Lee","year":"2019","unstructured":"Lee JA, Kim DJ, Hwang O (2019) KMS99220 exerts anti-inflammatory effects, activates the Nrf2 signaling and interferes with IKK, JNK and p38 MAPK via HO-1. Mol Cells 42(10):702","journal-title":"Mol Cells"},{"issue":"31","key":"1452_CR44","doi-asserted-by":"publisher","first-page":"8307","DOI":"10.1021\/acs.jafc.8b02607","volume":"66","author":"C Li","year":"2018","unstructured":"Li C, Tang B, Feng Y, Tang F, Pui-Man Hoi M, Su Z, Ming-Yuen Lee S (2018) Pinostrobin exerts neuroprotective actions in neurotoxin-induced Parkinson\u2019s disease models through Nrf2 induction. J Agric Food Chem 66(31):8307\u20138318","journal-title":"J Agric Food Chem"},{"key":"1452_CR45","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1007\/s12035-020-01934-1","volume":"57","author":"X Li","year":"2020","unstructured":"Li X, Zhang J, Rong H, Zhang X, Dong M (2020) Ferulic acid ameliorates MPP+\/MPTP-induced oxidative stress via ERK1\/2-dependent Nrf2 activation: translational implications for Parkinson disease treatment. Mol Neurobiol 57:2981\u20132995","journal-title":"Mol Neurobiol"},{"key":"1452_CR46","doi-asserted-by":"publisher","first-page":"111862","DOI":"10.1016\/j.ejmech.2019.111862","volume":"185","author":"Q Li","year":"2020","unstructured":"Li Q, Xing S, Chen Y, Liao Q, Li Q, Liu Y, He S, Feng F, Chen Y, Zhang J, Liu W (2020a) Reasonably activating Nrf2: a long-term, effective and controllable strategy for neurodegenerative diseases. Eur J Med Chem 185:111862. https:\/\/doi.org\/10.1016\/j.ejmech.2019.111862","journal-title":"Eur J Med Chem"},{"key":"1452_CR47","doi-asserted-by":"publisher","first-page":"111644","DOI":"10.1016\/j.fct.2020.111644","volume":"144","author":"X Li","year":"2020","unstructured":"Li X, Zhang J, Zhang X, Dong M (2020b) Puerarin suppresses MPP+\/MPTP-induced oxidative stress through an Nrf2-dependent mechanism. Food Chem Toxicol 144:111644","journal-title":"Food Chem Toxicol"},{"key":"1452_CR48","doi-asserted-by":"publisher","first-page":"101817","DOI":"10.1016\/j.arr.2022.101817","volume":"84","author":"J Li","year":"2023","unstructured":"Li J, Yang D, Li Z, Zhao M, Wang D, Sun Z, Wen P, Dai Y, Gou F, Ji Y, Zhao D (2023) PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases. Ageing Res Rev 84:101817","journal-title":"Ageing Res Rev"},{"issue":"5","key":"1452_CR49","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.phrs.2008.03.004","volume":"57","author":"JH Lim","year":"2008","unstructured":"Lim JH, Kim KM, Kim SW, Hwang O, Choi HJ (2008) Bromocriptine activates NQO1 via Nrf2-PI3K\/Akt signaling: novel cytoprotective mechanism against oxidative damage. Pharmacol Res 57(5):325\u2013331","journal-title":"Pharmacol Res"},{"issue":"46","key":"1452_CR50","doi-asserted-by":"publisher","first-page":"12385","DOI":"10.1021\/acs.jafc.8b04341","volume":"66","author":"J Lin","year":"2018","unstructured":"Lin J, Xia J, Zhao HS, Hou R, Talukder M, Yu L, Guo JY, Li JL (2018) Lycopene triggers nrf2\u2013AMPK cross talk to alleviate atrazine-induced nephrotoxicity in mice. J Agric Food Chem 66(46):12385\u201312394","journal-title":"J Agric Food Chem"},{"issue":"2","key":"1452_CR51","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/cbin.11505","volume":"45","author":"L Liu","year":"2021","unstructured":"Liu L, Yang S, Wang H (2021) \u03b1-Lipoic acid alleviates ferroptosis in the MPP+\u2010induced PC12 cells via activating the PI3K\/Akt\/Nrf2 pathway. Cell Biol Int 45(2):422\u2013431. https:\/\/doi.org\/10.1002\/cbin.11505","journal-title":"Cell Biol Int"},{"issue":"3","key":"1452_CR52","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/jnc.15969","volume":"167","author":"R Liu","year":"2023","unstructured":"Liu R, Yang J, Li Y, Xie J, Wang J (2023) Heme oxygenase-1: the roles of both good and evil in neurodegenerative diseases. J Neurochem 167(3):347\u2013361","journal-title":"J Neurochem"},{"issue":"12","key":"1452_CR53","doi-asserted-by":"publisher","first-page":"10774","DOI":"10.1039\/D0FO02165B","volume":"11","author":"L Ma","year":"2020","unstructured":"Ma L, Zhang B, Liu J, Qiao C, Liu Y, Li S, Lv H (2020) Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK\/AKT\/Nrf2 signalling pathway. Food Funct 11(12):10774\u201310785","journal-title":"Food Funct"},{"key":"1452_CR54","doi-asserted-by":"publisher","first-page":"1156333","DOI":"10.3389\/fphar.2023.1156333","volume":"14","author":"C Mancuso","year":"2023","unstructured":"Mancuso C (2023) The impact of heme oxygenase-2 on pharmacological research: a bibliometric analysis and beyond. Front Pharmacol 14:1156333","journal-title":"Front Pharmacol"},{"key":"1452_CR55","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neulet.2016.01.046","volume":"616","author":"S Mitra","year":"2016","unstructured":"Mitra S, Ghosh N, Sinha P, Chakrabarti N, Bhattacharyya A (2016) Alteration of nuclear factor-kappab pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine treatment. Neurosci Lett 616:86\u201392. https:\/\/doi.org\/10.1016\/j.neulet.2016.01.046","journal-title":"Neurosci Lett"},{"issue":"33","key":"1452_CR56","first-page":"4936","volume":"23","author":"I Miyazaki","year":"2017","unstructured":"Miyazaki I, Asanuma M (2017) Therapeutic strategy of targeting astrocytes for neuroprotection in Parkinson\u2019s disease. Curr Pharm Design 23(33):4936\u20134947","journal-title":"Curr Pharm Design"},{"issue":"10423","key":"1452_CR57","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","volume":"403","author":"HR Morris","year":"2024","unstructured":"Morris HR, Spillantini MG, Sue CM, Williams-Gray CH (2024) The pathogenesis of Parkinson\u2019s disease. Lancet 403(10423):293\u2013304","journal-title":"Lancet"},{"issue":"7","key":"1452_CR58","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00109-021-02071-5","volume":"99","author":"Y Niu","year":"2021","unstructured":"Niu Y, Zhang J, Dong M (2021) Nrf2 as a potential target for Parkinson\u2019s disease therapy. J Mol Med 99(7):917\u2013931. https:\/\/doi.org\/10.1007\/s00109-021-02071-5","journal-title":"J Mol Med"},{"issue":"11","key":"1452_CR59","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.3390\/antiox10111649","volume":"10","author":"JA Parga","year":"2021","unstructured":"Parga JA, Rodriguez-Perez AI, Garcia-Garrote M, Rodriguez-Pallares J, Labandeira-Garcia JL (2021) NRF2 activation and downstream effects: Focus on Parkinson\u2019s Disease and Brain Angiotensin. Antioxidants 10(11):1649. https:\/\/doi.org\/10.3390\/antiox10111649","journal-title":"Antioxidants"},{"issue":"2","key":"1452_CR60","doi-asserted-by":"publisher","first-page":"178","DOI":"10.4062\/biomolther.2018.234","volume":"27","author":"JS Park","year":"2019","unstructured":"Park JS, Leem YH, Park JE, Kim DY, Kim HS (2019) Neuroprotective effect of \u03b2-lapachone in MPTP-induced Parkinson\u2019s disease mouse model: involvement of astroglial p-AMPK\/Nrf2\/HO-1 signaling pathways. Biomolecules Ther 27(2):178","journal-title":"Biomolecules Ther"},{"issue":"1","key":"1452_CR61","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/mds.27878","volume":"35","author":"S Petrillo","year":"2020","unstructured":"Petrillo S, Schirinzi T, Di Lazzaro G, D\u2019Amico J, Colona VL, Bertini E, Pierantozzi M, Mari L, Mercuri NB, Piemonte F, Pisani A (2020) Systemic activation of Nrf2 pathway in Parkinson\u2019s disease. Mov Disord 35(1):180\u2013184","journal-title":"Mov Disord"},{"key":"1452_CR62","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1590\/s1677-5538.ibju.2018.0232","volume":"44","author":"EC Polat","year":"2018","unstructured":"Polat EC, Besiroglu H, Ozcan L, Otunctemur A, Eruyar AT, Somay A, Ozbay N, Cekmen M, Eraldemir C, Ozbek E (2018) Beneficial effects of Oltipraz, nuclear factor-erythroid\u20132-related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model. Int braz j urol 44:1243\u20131251","journal-title":"Int braz j urol"},{"issue":"6","key":"1452_CR63","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1128\/MCB.01204-10","volume":"31","author":"P Rada","year":"2011","unstructured":"Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A (2011) SCF\/\u03b2-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol 31(6):1121\u20131133. https:\/\/doi.org\/10.1128\/MCB.01204-10","journal-title":"Mol Cell Biol"},{"key":"1452_CR64","doi-asserted-by":"publisher","first-page":"101915","DOI":"10.1016\/j.arr.2023.101915","volume":"87","author":"S Rajan","year":"2023","unstructured":"Rajan S, Tryphena KP, Khan S, Vora L, Srivastava S, Singh SB, Khatri DK (2023) Understanding the involvement of innate immunity and the Nrf2-NLRP3 axis on mitochondrial health in Parkinson\u2019s disease. Ageing Res Rev 87:101915","journal-title":"Ageing Res Rev"},{"issue":"8","key":"1452_CR65","first-page":"1412","volume":"14","author":"AS Rathore","year":"2023","unstructured":"Rathore AS, Singh SS, Birla H, Zahra W, Keshri PK, Dilnashin H, Singh R, Singh S, Singh SP (2023) Curcumin modulates p62\u2013Keap1\u2013Nrf2-Mediated autophagy in Rotenone-Induced Parkinson\u2019s Disease Mouse models. ACS Chem Neurosci 14(8):1412\u20131423","journal-title":"ACS Chem Neurosci"},{"issue":"22","key":"1452_CR66","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.3390\/molecules25225474","volume":"25","author":"S Saha","year":"2020","unstructured":"Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25(22):5474. https:\/\/doi.org\/10.3390\/molecules25225474","journal-title":"Molecules"},{"key":"1452_CR67","doi-asserted-by":"publisher","first-page":"787258","DOI":"10.3389\/fncel.2021.787258","volume":"15","author":"S Saha","year":"2022","unstructured":"Saha S, Buttari B, Profumo E, Tucci P, Saso L (2022) A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer\u2019s and Parkinson\u2019s diseases. Front Cell Neurosci 15:787258","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"1452_CR68","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13578-022-00951-y","volume":"13","author":"S Sandouka","year":"2023","unstructured":"Sandouka S, Saadi A, Singh PK, Olowe R, Shekh-Ahmad T (2023) Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy. Cell Bioscience 13(1):3","journal-title":"Cell Bioscience"},{"issue":"4","key":"1452_CR69","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3390\/antiox12040817","volume":"12","author":"G Sani","year":"2023","unstructured":"Sani G, Margoni S, Brugnami A, Ferrara OM, Bernardi E, Simonetti A, Monti L, Mazza M, Janiri D, Moccia L, Kotzalidis GD (2023) The Nrf2 pathway in depressive disorders: a systematic review of animal and human studies. Antioxidants 12(4):817","journal-title":"Antioxidants"},{"issue":"3","key":"1452_CR70","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3390\/antiox12030673","volume":"12","author":"J Segura-Aguilar","year":"2023","unstructured":"Segura-Aguilar J, Mannervik B (2023) A preclinical model for parkinson\u2019s disease based on transcriptional gene activation via KEAP1\/NRF2 to develop new antioxidant therapies. Antioxidants 12(3):673","journal-title":"Antioxidants"},{"issue":"8","key":"1452_CR71","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1007\/s11033-023-08573-4","volume":"50","author":"V Sharma","year":"2023","unstructured":"Sharma V, Singh TG (2023) Drug induced nephrotoxicity-A mechanistic approach. Mol Biol Rep 50(8):6975\u20136986","journal-title":"Mol Biol Rep"},{"key":"1452_CR72","first-page":"1","volume":"21","author":"V Sharma","year":"2022","unstructured":"Sharma V, Singh TG (2022) Therapeutic implications of glucose transporters (GLUT) in cerebral ischemia. Neurochem Res 21:1\u20134","journal-title":"Neurochem Res"},{"key":"1452_CR73","doi-asserted-by":"publisher","first-page":"110373","DOI":"10.1016\/j.biopha.2020.110373","volume":"129","author":"V Sharma","year":"2020","unstructured":"Sharma V, Kaur A, Singh TG (2020) Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer\u2019s disease. Biomed Pharmacother 129:110373","journal-title":"Biomed Pharmacother"},{"issue":"s1","key":"1452_CR74","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.3233\/JAD-220793","volume":"94","author":"SM Shirgadwar","year":"2023","unstructured":"Shirgadwar SM, Kumar R, Preeti K, Khatri DK, Singh SB (2023) Neuroprotective effect of phloretin in rotenone-induced mice model of Parkinson\u2019s disease: modulating mTOR-NRF2-p62 mediated autophagy-oxidative stress crosstalk. J Alzheimers Dis 94(s1):S109\u2013S124","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1452_CR75","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3390\/cancers13010046","volume":"13","author":"K Taguchi","year":"2020","unstructured":"Taguchi K, Yamamoto M (2020) The KEAP1\u2013NRF2 system as a molecular target of cancer treatment. Cancers 13(1):46","journal-title":"Cancers"},{"issue":"5","key":"1452_CR76","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/bpa.12214","volume":"25","author":"K Tanji","year":"2015","unstructured":"Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, Mori F, Warabi E, Yanagawa T, Ueno S, Itoh K (2015) P 62 Deficiency enhances \u03b1-Synuclein Pathology in mice. Brain Pathol 25(5):552\u2013564","journal-title":"Brain Pathol"},{"issue":"9","key":"1452_CR77","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1007\/s12031-021-01841-7","volume":"71","author":"K Thapa","year":"2021","unstructured":"Thapa K, Khan H, Singh TG, Kaur A (2021) Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neurosci 71(9):1725\u20131742","journal-title":"J Mol Neurosci"},{"key":"1452_CR78","first-page":"1","volume":"24","author":"A Thirupathi","year":"2024","unstructured":"Thirupathi A, Marqueze LF, Outeiro TF, Radak Z, Pinho RA (2024) Physical exercise-induced activation of NRF2 and BDNF as a promising strategy for ferroptosis regulation in Parkinson\u2019s disease. Neurochemical Res 24:1\u20132","journal-title":"Neurochemical Res"},{"issue":"10","key":"1452_CR79","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","volume":"73","author":"H Wang","year":"2013","unstructured":"Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ (2013) RXR\u03b1 inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. Cancer Res 73(10):3097\u20133108. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-3386","journal-title":"Cancer Res"},{"issue":"1","key":"1452_CR80","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10571-020-00844-z","volume":"41","author":"G Wang","year":"2021","unstructured":"Wang G, Yang Q, Zheng C, Li D, Li J, Zhang F (2021) Physiological concentration of H2O2 supports dopamine neuronal survival via activation of Nrf2 signaling in glial cells. Cell Mol Neurobiol 41(1):163\u2013171. https:\/\/doi.org\/10.1007\/s10571-020-00844-z","journal-title":"Cell Mol Neurobiol"},{"key":"1452_CR81","doi-asserted-by":"publisher","first-page":"113848","DOI":"10.1016\/j.biopha.2022.113848","volume":"156","author":"Q Wang","year":"2022","unstructured":"Wang Q, Botchway BO, Zhang Y, Liu X (2022) Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson\u2019s disease: a review. Biomed Pharmacother 156:113848","journal-title":"Biomed Pharmacother"},{"key":"1452_CR82","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.tox.2014.01.008","volume":"318","author":"J Wu","year":"2014","unstructured":"Wu J, Liu X, Fan J, Chen W, Wang J, Zeng Y, Feng X, Yu X, Yang X (2014) Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway. Toxicology 318:22\u201331","journal-title":"Toxicology"},{"issue":"2\u20133","key":"1452_CR83","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.tox.2011.10.007","volume":"290","author":"H Xiao","year":"2011","unstructured":"Xiao H, Lv F, Xu W, Zhang L, Jing P, Cao X (2011) Deprenyl prevents MPP+-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K\/Akt and Erk. Toxicology 290(2\u20133):286\u2013294. https:\/\/doi.org\/10.1016\/j.tox.2011.10.007","journal-title":"Toxicology"},{"issue":"6","key":"1452_CR84","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1159\/000485947","volume":"44","author":"W Xu","year":"2017","unstructured":"Xu W, Zheng D, Liu Y, Li J, Yang L, Shang X (2017) Glaucocalyxin B alleviates lipopolysaccharide-induced Parkinson\u2019s disease by inhibiting TLR\/NF-\u03baB and activating Nrf2\/HO-1 pathway. Cell Physiol Biochem 44(6):2091\u20132104. https:\/\/doi.org\/10.1159\/000485947","journal-title":"Cell Physiol Biochem"},{"issue":"9","key":"1452_CR85","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1039\/D0FO02836C","volume":"12","author":"T Yan","year":"2021","unstructured":"Yan T, Mao Q, Zhang X, Wu B, Bi K, He B, Jia Y (2021) Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis via the BDNF\/Nrf2\/NF-\u03baB pathway in 6-OHDA-induced Parkinson\u2019s disease mice. Food Funct 12(9):4079\u20134091","journal-title":"Food Funct"},{"key":"1452_CR86","doi-asserted-by":"publisher","first-page":"105651","DOI":"10.1016\/j.intimp.2019.05.036","volume":"75","author":"C Yang","year":"2019","unstructured":"Yang C, Mo Y, Xu E, Wen H, Wei R, Li S, Zheng J, Li W, Le B, Chen Y, Pan H (2019) Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson\u2019s disease mouse model. Int Immunopharmacol 75:105651","journal-title":"Int Immunopharmacol"},{"key":"1452_CR87","doi-asserted-by":"publisher","first-page":"919233","DOI":"10.3389\/fphar.2022.919233","volume":"13","author":"XX Yang","year":"2022","unstructured":"Yang XX, Yang R, Zhang F (2022) Role of Nrf2 in Parkinson\u2019s disease: toward new perspectives. Front Pharmacol 13:919233","journal-title":"Front Pharmacol"},{"issue":"1","key":"1452_CR88","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12967-023-04802-3","volume":"22","author":"L Yuhan","year":"2024","unstructured":"Yuhan L, Khaleghi Ghadiri M, Gorji A (2024) Impact of NQO1 dysregulation in CNS disorders. J Translational Med 22(1):4","journal-title":"J Translational Med"},{"issue":"6","key":"1452_CR89","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1007\/s11033-023-08409-1","volume":"50","author":"MY Zamanian","year":"2023","unstructured":"Zamanian MY, Parra RM, Soltani A, Kujawska M, Mustafa YF, Raheem G, Al-Awsi L, Lafta HA, Taheri N, Heidari M, Golmohammadi M (2023) Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson\u2019s disease: an overview and update on new developments. Mol Biol Rep 50(6):5455\u20135464","journal-title":"Mol Biol Rep"},{"issue":"17","key":"1452_CR90","doi-asserted-by":"publisher","first-page":"9592","DOI":"10.3390\/ijms22179592","volume":"22","author":"E Zgorzynska","year":"2021","unstructured":"Zgorzynska E, Dziedzic B, Walczewska A (2021) An overview of the nrf2\/are pathway and its role in neurodegenerative diseases. Int J Mol Sci 22(17):9592. https:\/\/doi.org\/10.3390\/ijms22179592","journal-title":"Int J Mol Sci"},{"issue":"33","key":"1452_CR91","doi-asserted-by":"publisher","first-page":"8171","DOI":"10.1021\/jf301511m","volume":"60","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Cui W, Li G, Yuan S, Xu D, Hoi MP, Lin Z, Dou J, Han Y, Lee SM (2012) Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1\/Nrf2\/HO-1 and involving PKC\u03b1 and PI3K\/AKT signaling pathways. J Agric Food Chem 60(33):8171\u20138182","journal-title":"J Agric Food Chem"},{"key":"1452_CR92","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2015.02.030","volume":"84","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Li G, Szeto SS, Chong CM, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y, Siu KM (2015) Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic Biol Med 84:331\u2013343","journal-title":"Free Radic Biol Med"},{"key":"1452_CR93","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.exger.2017.10.021","volume":"100","author":"J Zhang","year":"2017","unstructured":"Zhang J, Tong W, Sun H, Jiang M, Shen Y, Liu Y, Gu H, Guo J, Fang J, Jin L (2017) Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K\/AKT\/GSK3\u03b2 pathway. Exp Gerontol 100:77\u201386. https:\/\/doi.org\/10.1016\/j.exger.2017.10.021","journal-title":"Exp Gerontol"},{"key":"1452_CR94","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12031-019-01349-1","volume":"69","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Xu W, Nan S, Chang M, Fan J (2019) MicroRNA-326 inhibits apoptosis and promotes proliferation of dopaminergic neurons in Parkinson\u2019s disease through suppression of KLK7-mediated MAPK signaling pathway. J Mol Neurosci 69:197\u2013214","journal-title":"J Mol Neurosci"},{"issue":"3","key":"1452_CR95","first-page":"2354","volume":"8","author":"Y Zhao","year":"2015","unstructured":"Zhao Y, Zhang Q, Xi J, Xiao B, Li Y, Ma C (2015) Neuroprotective effect of fasudil on inflammation through PI3K\/Akt and Wnt\/\u03b2-catenin dependent pathways in a mice model of Parkinson\u2019s disease. Int J Clin Exp Pathol 8(3):2354","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-024-01452-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-024-01452-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-024-01452-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:02:25Z","timestamp":1740549745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-024-01452-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":95,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["1452"],"URL":"https:\/\/doi.org\/10.1007\/s11011-024-01452-2","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"26 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"70"}}