{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:15Z","timestamp":1790188215501,"version":"4.1.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-025-01543-8","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:33:14Z","timestamp":1740562394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacological modulation of PI3K\/PTEN\/Akt\/mTOR\/ERK signaling pathways in ischemic injury: a mechanistic perspective"],"prefix":"10.1007","volume":"40","author":[{"given":"Heena","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashvardhan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot Kaur","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"1543_CR1","doi-asserted-by":"crossref","unstructured":"Arora B, Khan H, Grewal AK, Singh TG (2023) Mechanistic insights on the role of nitric oxide in ischemia-reperfusion injury. In\u00a0Nitric Oxide in Health and Disease,\u00a0pp 275\u2013285. Academic Press","DOI":"10.1016\/B978-0-443-13342-8.00004-1"},{"key":"1543_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3389\/fonc.2015.00166","volume":"5","author":"M Berm\u00fadez Brito","year":"2015","unstructured":"Berm\u00fadez Brito M, Goulielmaki E, Papakonstanti EA (2015) Focus on PTEN regulation. Front Oncol 5:166. https:\/\/doi.org\/10.3389\/fonc.2015.00166","journal-title":"Front Oncol"},{"issue":"6","key":"1543_CR3","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/jep.12342","volume":"21","author":"M B\u00e9rub\u00e9","year":"2015","unstructured":"B\u00e9rub\u00e9 M, Albert M, Chauny JM, Contandriopoulos D, DuSablon A, Lacroix S, Gagn\u00e9 A, Laflamme \u00c9, Boutin N, Delisle S, Pauz\u00e9 AM (2015) Development of theory-based knowledge translation interventions to facilitate the implementation of evidence-based guidelines on the early management of adults with traumatic spinal cord injury. J Eval Clin Pract 21(6):1157\u20131168. https:\/\/doi.org\/10.1111\/jep.12342","journal-title":"J Eval Clin Pract"},{"key":"1543_CR4","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.biopha.2018.06.091","volume":"105","author":"Y Cai","year":"2018","unstructured":"Cai Y, Wang W, Qiu Y, Yu M, Yin J, Yang H, Mei J (2018) KGF inhibits hypoxia-induced intestinal epithelial cell apoptosis by upregulating AKT\/ERK pathway-dependent E-cadherin expression. Biomed Pharmacother 105:1318\u20131324. https:\/\/doi.org\/10.1016\/j.biopha.2018.06.091","journal-title":"Biomed Pharmacother"},{"key":"1543_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jneuroim.2017.11.015","volume":"315","author":"C Chang","year":"2018","unstructured":"Chang C, Zhao Y, Song G, She K (2018) Resveratrol protects hippocampal neurons against cerebral ischemia-reperfusion injury via modulating JAK\/ERK\/STAT signaling pathway in rats. J Neuroimmunol 315:9\u201314. https:\/\/doi.org\/10.1016\/j.jneuroim.2017.11.015","journal-title":"J Neuroimmunol"},{"key":"1543_CR6","doi-asserted-by":"publisher","unstructured":"Chen HH, Lu PJ, Chen BR, Hsiao M, Ho WY, Tseng CJ (2015) Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1\/2-enhanced tubular epithelium proliferation.\u00a0Biochim Biophys Acta (BBA) Mol Basis Dis\u00a01852(10): 2195\u20132201. https:\/\/doi.org\/10.1016\/j.bbadis.2015.07.018","DOI":"10.1016\/j.bbadis.2015.07.018"},{"issue":"2","key":"1543_CR7","first-page":"563","volume":"10","author":"Q Chen","year":"2018","unstructured":"Chen Q, Huang X, Li R (2018) lncRNA MALAT1\/miR-205-5p axis regulates MPP+-induced cell apoptosis in MN9D cells by directly targeting LRRK2. American Journal of Translational Research 10(2):563","journal-title":"American Journal of Translational Research"},{"key":"1543_CR8","unstructured":"Chen W, Ruan Y, Zhao S, Ning J, Rao T, Yu W, Zhou X, Liu C, Qi Y, Cheng F (2019) MicroRNA-205 inhibits the apoptosis of renal tubular epithelial cells via the PTEN\/Akt pathway in renal ischemia-reperfusion injury. Am J Transl Res 11(12):7364"},{"key":"1543_CR9","unstructured":"Chen Z (2017)\u00a0Mechanistic Insights into the Auto-Regulation of PTEN and Its Related HECT E3 Ligases\u00a0(Doctoral dissertation, Johns Hopkins University). http:\/\/jhir.library.jhu.edu\/handle\/1774.2\/58616"},{"issue":"6","key":"1543_CR10","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3390\/cells10061333","volume":"10","author":"TF Chen-Yoshikawa","year":"2021","unstructured":"Chen-Yoshikawa TF (2021) Ischemia\u2013reperfusion injury in lung transplantation. Cells 10(6):1333. https:\/\/doi.org\/10.3390\/cells10061333","journal-title":"Cells"},{"key":"1543_CR11","unstructured":"Chi Y, Ma Q, Ding XQ, Qin X, Wang C, Zhang J (2019) Research on protective mechanism of ibuprofen in myocardial ischemia-reperfusion injury in rats through the PI3K\/Akt\/mTOR signaling pathway.\u00a0Eur Rev Med Pharmacol Sci\u00a023(10)"},{"key":"1543_CR12","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3389\/fonc.2019.01373","volume":"9","author":"KG de la Cruz L\u00f3pez","year":"2019","unstructured":"de la Cruz L\u00f3pez KG, Toledo Guzm\u00e1n ME, S\u00e1nchez EO, Garc\u00eda Carranc\u00e1 A (2019) mTORC1 as a regulator of mitochondrial functions and a therapeutic target in cancer. Front Oncol 9:1373. https:\/\/doi.org\/10.3389\/fonc.2019.01373","journal-title":"Front Oncol"},{"key":"1543_CR13","doi-asserted-by":"publisher","unstructured":"Deng W, Wang Y, Long X, Zhao R, Wang Z, Liu Z, Cao S, Shi B (2016) miR-21 reduces hydrogen peroxide-induced apoptosis in c-kit+ cardiac stem cells in vitro through PTEN\/PI3K\/Akt signaling.\u00a0Oxid Med Cell Long\u00a02016. https:\/\/doi.org\/10.1155\/2016\/5389181","DOI":"10.1155\/2016\/5389181"},{"issue":"2","key":"1543_CR14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1053\/j.gastro.2005.05.054","volume":"129","author":"ON El-Assal","year":"2005","unstructured":"El-Assal ON, Besner GE (2005) HB-EGF enhances restitution after intestinal ischemia\/reperfusion via PI3K\/Akt and MEK\/ERK1\/2 activation. Gastroenterology 129(2):609\u2013625. https:\/\/doi.org\/10.1053\/j.gastro.2005.05.054","journal-title":"Gastroenterology"},{"key":"1543_CR15","doi-asserted-by":"publisher","unstructured":"El-Tanani M, Nsairat H, Aljabali AA, Serrano-Aroca-Angel \u00c1, Mishra V, Mishra Y, Naikoo GA, Alshaer W, Tambuwala MM (2023) Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis.\u00a0Life Sci\u00a0121662. https:\/\/doi.org\/10.1016\/j.lfs.2023.121662","DOI":"10.1016\/j.lfs.2023.121662"},{"issue":"1","key":"1543_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13018-020-01790-8","volume":"15","author":"J Fu","year":"2020","unstructured":"Fu J, Sun H, Wei H, Dong M, Zhang Y, Xu W, Fang Y, Zhao J (2020) Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K\/Akt\/GSK-3\u03b2 pathway in rats. J Orthop Surg Res 15(1):1\u201311. https:\/\/doi.org\/10.1186\/s13018-020-01790-8","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"1543_CR17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/bmb\/59.1.193","volume":"59","author":"AV Ghuran","year":"2001","unstructured":"Ghuran AV, Camm AJ (2001) Ischaemic heart disease presenting as arrhythmias. Br Med Bull 59(1):193\u2013210. https:\/\/doi.org\/10.1093\/bmb\/59.1.193","journal-title":"Br Med Bull"},{"issue":"1","key":"1543_CR18","doi-asserted-by":"publisher","first-page":"047","DOI":"10.1515\/med-2021-0005","volume":"16","author":"L Gong","year":"2020","unstructured":"Gong L, Wang X, Pan J, Zhang M, Liu D, Liu M, Li L, An F (2020) The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K\/AKt\/mTOR signaling pathway in myocardial ischemia\/reperfusion injury rats. Open Medicine 16(1):047\u2013057. https:\/\/doi.org\/10.1515\/med-2021-0005","journal-title":"Open Medicine"},{"issue":"10","key":"1543_CR19","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1111\/j.1399-6576.2011.02526.x","volume":"55","author":"J Gu","year":"2011","unstructured":"Gu J, Chen J, Xia P, Tao G, Zhao H, Ma D (2011) Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Acta Anaesthesiol Scand 55(10):1272\u20131278. https:\/\/doi.org\/10.1111\/j.1399-6576.2011.02526.x","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"1543_CR20","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s10753-022-01762-6","volume":"46","author":"X He","year":"2023","unstructured":"He X, Xiao J, Li Z, Ye M, Lin J, Liu Z, Liang Y, Dai H, Jing R, Lin F (2023) Inhibition of PD-1 Alters the SHP1\/2-PI3K\/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia-Reperfusion Injury. Inflammation 46(2):639\u2013654. https:\/\/doi.org\/10.1007\/s10753-022-01762-6","journal-title":"Inflammation"},{"issue":"12","key":"1543_CR21","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.4049\/jimmunol.1800987","volume":"201","author":"C Hu","year":"2018","unstructured":"Hu C, Li L, Ding P, Li L, Ge X, Zheng L, Wang X, Wang J, Zhang W, Wang N, Gu H (2018) Complement inhibitor CRIg\/FH ameliorates renal ischemia reperfusion injury via activation of PI3K\/AKT signaling. J Immunol 201(12):3717\u20133730. https:\/\/doi.org\/10.4049\/jimmunol.1800987","journal-title":"J Immunol"},{"key":"1543_CR22","doi-asserted-by":"publisher","first-page":"912","DOI":"10.2119\/molmed.2015.00056","volume":"21","author":"S Hu","year":"2015","unstructured":"Hu S, Zhang Y, Zhang M, Guo Y, Yang P, Zhang S, Simsekyilmaz S, Xu JF, Li J, Xiang X, Yu Q (2015) Aloperine protects mice against ischemia-reperfusion (IR)-induced renal injury by regulating PI3K\/AKT\/mTOR signaling and AP-1 activity. Mol Med 21:912\u2013923. https:\/\/doi.org\/10.2119\/molmed.2015.00056","journal-title":"Mol Med"},{"key":"1543_CR23","doi-asserted-by":"publisher","unstructured":"Izzo AA, Camilleri M (2008) Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects. Gut 57(8):1140\u20131155. https:\/\/doi.org\/10.1136\/gut.2008.148791","DOI":"10.1136\/gut.2008.148791"},{"issue":"4","key":"1543_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/08977190701779101","volume":"25","author":"K Jastrzebski","year":"2007","unstructured":"Jastrzebski K, Hannan KM, Tchoubrieva EB, Hannan RD, Pearson RB (2007) Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25(4):209\u2013226. https:\/\/doi.org\/10.1080\/08977190701779101","journal-title":"Growth Factors"},{"key":"1543_CR25","doi-asserted-by":"publisher","unstructured":"Kai-Lan W, Si Z (2015) Pretreatment with erythropoietin attenuates intestinal ischemia reperfusion injury by further promoting PI3K\/Akt signaling activation. In: Transplantation\u00a0Proceedings, vol 47, no 6. Elsevier, pp 1639\u20131645.\u00a0https:\/\/doi.org\/10.1016\/j.transproceed.2015.02.023","DOI":"10.1016\/j.transproceed.2015.02.023"},{"key":"1543_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","volume":"298","author":"T Kalogeris","year":"2012","unstructured":"Kalogeris T, Baines CP, Krenz M, Korthuis RJ (2012) Cell biology of ischemia\/reperfusion injury. Int Rev Cell Mol Biol 298:229\u2013317. https:\/\/doi.org\/10.1016\/B978-0-12-394309-5.00006-7","journal-title":"Int Rev Cell Mol Biol"},{"issue":"7","key":"1543_CR27","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1002\/ar.24292","volume":"303","author":"EO Kamel","year":"2020","unstructured":"Kamel EO, Hassanein EH, Ahmed MA, Ali FE (2020) Perindopril ameliorates hepatic ischemia reperfusion injury via regulation of NF-\u03baB-p65\/TLR-4, JAK1\/STAT-3, Nrf-2, and PI3K\/Akt\/mTOR signaling pathways. Anat Rec 303(7):1935\u20131949. https:\/\/doi.org\/10.1002\/ar.24292","journal-title":"Anat Rec"},{"issue":"1","key":"1543_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/WCO.0000000000000633","volume":"32","author":"AH Katsanos","year":"2019","unstructured":"Katsanos AH, Tsivgoulis G (2019) Is intravenous thrombolysis still necessary in patients who undergo mechanical thrombectomy? Curr Opin Neurol 32(1):3\u201312. https:\/\/doi.org\/10.1097\/WCO.0000000000000633","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"1543_CR29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10787-017-0336-1","volume":"25","author":"A Kaur","year":"2017","unstructured":"Kaur A, Sharma S (2017) Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases. Inflammopharmacology 25(3):293\u2013312. https:\/\/doi.org\/10.1007\/s10787-017-0336-1","journal-title":"Inflammopharmacology"},{"issue":"3","key":"1543_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/GCO.0000000000000268","volume":"28","author":"K Kawamura","year":"2016","unstructured":"Kawamura K, Kawamura N, Hsueh AJ (2016) Activation of dormant follicles: a new treatment for premature ovarian failure? Curr Opin Obstet Gynecol 28(3):217. https:\/\/doi.org\/10.1097\/GCO.0000000000000268","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"2","key":"1543_CR31","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jhep.2011.05.023","volume":"56","author":"B Ke","year":"2012","unstructured":"Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MCS, Busuttil RW, Kupiec-Weglinski JW (2012) HO-1\u2013STAT3 axis in mouse liver ischemia\/reperfusion injury: Regulation of TLR4 innate responses through PI3K\/PTEN signaling. J Hepatol 56(2):359\u2013366. https:\/\/doi.org\/10.1016\/j.jhep.2011.05.023","journal-title":"J Hepatol"},{"issue":"5","key":"1543_CR32","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.3390\/molecules26123724","volume":"75","author":"N Khakha","year":"2023","unstructured":"Khakha N, Khan H, Kaur A, Singh TG (2023) Therapeutic implications of phosphorylation-and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration. Pharmacol Rep 75(5):1152\u20131165. https:\/\/doi.org\/10.3390\/molecules26123724","journal-title":"Pharmacol Rep"},{"issue":"22","key":"1543_CR33","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1016\/j.jacc.2016.03.555","volume":"67","author":"P Khandelwal","year":"2016","unstructured":"Khandelwal P, Yavagal DR, Sacco RL (2016) Acute ischemic stroke intervention. J Am Coll Cardiol 67(22):2631\u20132644","journal-title":"J Am Coll Cardiol"},{"key":"1543_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.lfs.2018.09.013","volume":"211","author":"RM Khedr","year":"2018","unstructured":"Khedr RM, Ahmed AA, Kamel R, Raafat EM (2018) Sitagliptin attenuates intestinal ischemia\/reperfusion injury via cAMP\/PKA, PI3K\/Akt pathway in a glucagon-like peptide 1 receptor-dependent manner. Life Sci 211:31\u201339. https:\/\/doi.org\/10.1016\/j.lfs.2018.09.013","journal-title":"Life Sci"},{"issue":"6","key":"1543_CR35","doi-asserted-by":"publisher","first-page":"H2836","DOI":"10.1152\/ajpheart.00113.2006","volume":"291","author":"SJ Lee","year":"2006","unstructured":"Lee SJ, Namkoong S, Kim YM, Kim CK, Lee H, Ha KS, Chung HT, Kwon YG, Kim YM (2006) Fractalkine stimulates angiogenesis by activating the Raf-1\/MEK\/ERK-and PI3K\/Akt\/eNOS-dependent signal pathways. American Journal of Physiology-Heart and Circulatory Physiology 291(6):H2836\u2013H2846. https:\/\/doi.org\/10.1152\/ajpheart.00113.2006","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"10","key":"1543_CR36","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/mt.2016.102","volume":"24","author":"M Leibinger","year":"2016","unstructured":"Leibinger M, Andreadaki A, Gobrecht P, Levin E, Diekmann H, Fischer D (2016) Boosting central nervous system axon regeneration by circumventing limitations of natural cytokine signaling. Mol Ther 24(10):1712\u20131725. https:\/\/doi.org\/10.1038\/mt.2016.102","journal-title":"Mol Ther"},{"issue":"3","key":"1543_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1089\/ars.2016.6659","volume":"25","author":"JM Lever","year":"2016","unstructured":"Lever JM, Boddu R, George JF, Agarwal A (2016) Heme oxygenase-1 in kidney health and disease. Antioxid Redox Signal 25(3):165\u2013183. https:\/\/doi.org\/10.1089\/ars.2016.6659","journal-title":"Antioxid Redox Signal"},{"key":"1543_CR38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnana.2015.00048","volume":"9","author":"W Li","year":"2015","unstructured":"Li W, Yang Y, Hu Z, Ling S, Fang M (2015) Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K\/Akt\/mTOR pathway activation. Front Neuroanat 9:48. https:\/\/doi.org\/10.3389\/fnana.2015.00048","journal-title":"Front Neuroanat"},{"key":"1543_CR39","doi-asserted-by":"publisher","unstructured":"Li ST, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, Lu SH, Wang Q, Chen JW, Huang HQ, Liu PQ (2018) Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264. 7 cells by inhibiting the JNK\/NF-\u03baB signaling pathway and activating the PI3K\/Akt\/Nrf2 pathway.\u00a0Acta Pharmacol Sin 39(8):1294\u20131304. https:\/\/doi.org\/10.1038\/aps.2017.143","DOI":"10.1038\/aps.2017.143"},{"key":"1543_CR40","doi-asserted-by":"publisher","unstructured":"Li Q, Cui S, Jing G, Ding H, Xia Z, He X (2019) The role of PI3K\/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia\/reperfusion.\u00a0Acta Cir Bras\u00a034. https:\/\/doi.org\/10.1590\/s0102-865020190010000005","DOI":"10.1590\/s0102-865020190010000005"},{"key":"1543_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154644","volume":"110","author":"R Li","year":"2023","unstructured":"Li R, Zheng Y, Zhang J, Zhou Y, Fan X (2023) Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K\/AKT\/mTOR pathway. Phytomedicine 110:154644. https:\/\/doi.org\/10.1016\/j.phymed.2023.154644","journal-title":"Phytomedicine"},{"key":"1543_CR42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuroscience.2021.12.005","volume":"482","author":"J Li","year":"2022","unstructured":"Li J, Cheng X, Fu D, Liang Y, Chen C, Deng W, He L (2022) Autophagy of spinal microglia affects the activation of microglia through the PI3K\/AKT\/mTOR signaling pathway. Neuroscience 482:77\u201386. https:\/\/doi.org\/10.1016\/j.neuroscience.2021.12.005","journal-title":"Neuroscience"},{"issue":"1","key":"1543_CR43","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3892\/ol.2017.6232","volume":"14","author":"W Lim","year":"2017","unstructured":"Lim W, Song G (2017) Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K\/AKT and ERK 1\/2 MAPK signal transduction. Oncol Lett 14(1):810\u2013818. https:\/\/doi.org\/10.3892\/ol.2017.6232","journal-title":"Oncol Lett"},{"issue":"13","key":"1543_CR44","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1042\/CS20210476","volume":"135","author":"J Liu","year":"2021","unstructured":"Liu J, Liu D, Zhang X, Li Y, Fu X, He W, Li M, Chen P, Zeng G, DiSanto ME, Wang X (2021) NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia. Clin Sci 135(13):1591\u20131608. https:\/\/doi.org\/10.1042\/CS20210476","journal-title":"Clin Sci"},{"key":"1543_CR45","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jns.2016.07.009","volume":"368","author":"S Liu","year":"2016","unstructured":"Liu S, Yang Y, Jin M, Hou S, Dong X, Lu J, Cheng W (2016) Xenon-delayed postconditioning attenuates spinal cord ischemia\/reperfusion injury through activation AKT and ERK signaling pathways in rats. J Neurol Sci 368:277\u2013284. https:\/\/doi.org\/10.1016\/j.jns.2016.07.009","journal-title":"J Neurol Sci"},{"issue":"6","key":"1543_CR46","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.3892\/mmr.2015.3268","volume":"11","author":"J Ma","year":"2015","unstructured":"Ma J, Guo X, Zhang S, Liu H, Lu J, Dong Z, Liu K, Ming L (2015) Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. Mol Med Rep 11(6):4525\u20134531. https:\/\/doi.org\/10.3892\/mmr.2015.3268","journal-title":"Mol Med Rep"},{"issue":"12","key":"1543_CR47","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/neuonc\/nov152","volume":"17","author":"JP MacKeigan","year":"2015","unstructured":"MacKeigan JP, Krueger DA (2015) Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex. Neuro Oncol 17(12):1550\u20131559. https:\/\/doi.org\/10.1093\/neuonc\/nov152","journal-title":"Neuro Oncol"},{"key":"1543_CR48","unstructured":"M\u00e4emets-Allas K (2016) Studies on cell growth promoting AKT signaling pathway\u2013a promising anti-cancer drug target, 1\u201392"},{"key":"1543_CR49","doi-asserted-by":"publisher","unstructured":"Metzger G (2022) Der Transkriptionsfaktor CUX1 beeinflusst epigenetisch induzierte zellul\u00e4re Stressreaktionen im hepatozellul\u00e4ren Karzinom. https:\/\/doi.org\/10.17192\/z2022.0178","DOI":"10.17192\/z2022.0178"},{"issue":"14","key":"1543_CR50","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.lfs.2004.02.032","volume":"75","author":"I Mohanty","year":"2004","unstructured":"Mohanty I, Arya DS, Dinda A, Joshi S, Talwar KK, Gupta SK (2004) Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life Sci 75(14):1701\u20131711. https:\/\/doi.org\/10.1016\/j.lfs.2004.02.032","journal-title":"Life Sci"},{"issue":"1","key":"1543_CR51","doi-asserted-by":"publisher","first-page":"1886844","DOI":"10.1080\/19490976.2021.1886844","volume":"13","author":"AH Mohseni","year":"2021","unstructured":"Mohseni AH, Casolaro V, Berm\u00fadez-Humar\u00e1n LG, Keyvani H, Taghinezhad-S S (2021) Modulation of the PI3K\/Akt\/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut Microbes 13(1):1886844. https:\/\/doi.org\/10.1080\/19490976.2021.1886844","journal-title":"Gut Microbes"},{"issue":"1","key":"1543_CR52","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.mcn.2004.09.004","volume":"28","author":"F Molina-Holgado","year":"2005","unstructured":"Molina-Holgado F, Pinteaux E, Heenan L, Moore JD, Rothwell NJ, Gibson RM (2005) Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase\/AKT signaling. Mol Cell Neurosci 28(1):189\u2013194. https:\/\/doi.org\/10.1016\/j.mcn.2004.09.004","journal-title":"Mol Cell Neurosci"},{"issue":"17","key":"1543_CR53","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.phytochem.2006.06.020","volume":"67","author":"DG Nagle","year":"2006","unstructured":"Nagle DG, Ferreira D, Zhou YD (2006) Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. Phytochemistry 67(17):1849\u20131855. https:\/\/doi.org\/10.1016\/j.phytochem.2006.06.020","journal-title":"Phytochemistry"},{"key":"1543_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108902","volume":"108","author":"NK Prabhakar","year":"2022","unstructured":"Prabhakar NK, Khan H, Grewal AK, Singh TG (2022) Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches. Int Immunopharmacol 108:108902. https:\/\/doi.org\/10.1016\/j.intimp.2022.108902","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"1543_CR55","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033050","volume":"11","author":"CG Proud","year":"2019","unstructured":"Proud CG (2019) Phosphorylation and signal transduction pathways in translational control. Cold Spring Harb Perspect Biol 11(7):a033050","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1543_CR56","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s12640-019-0003-y","volume":"35","author":"SN Rai","year":"2019","unstructured":"Rai SN, Dilnashin H, Birla H, Singh SS, Zahra W, Rathore AS, Singh BK, Singh SP (2019) The role of PI3K\/Akt and ERK in neurodegenerative disorders. Neurotox Res 35:775\u2013795. https:\/\/doi.org\/10.1007\/s12640-019-0003-y","journal-title":"Neurotox Res"},{"issue":"5","key":"1543_CR57","doi-asserted-by":"publisher","first-page":"4813","DOI":"10.1007\/s11033-021-06462-2","volume":"48","author":"MJ Ramaiah","year":"2021","unstructured":"Ramaiah MJ, Kumar KR (2021) mTOR-Rictor-EGFR axis in oncogenesis and diagnosis of glioblastoma multiforme. Mol Biol Rep 48(5):4813\u20134835. https:\/\/doi.org\/10.1007\/s11033-021-06462-2","journal-title":"Mol Biol Rep"},{"key":"1543_CR58","unstructured":"Rear R (2017)\u00a0The effect of remote ischaemic preconditioning on contrast induced nephropathy in the clinical setting of coronary angiography and percutaneous coronary intervention\u00a0(Doctoral dissertation, UCL (University College London))"},{"key":"1543_CR59","doi-asserted-by":"publisher","unstructured":"Ren X, Wang Z, Guo C (2021) MiR-195\u20135p ameliorates cerebral ischemia-reperfusion injury by regulating the PTEN-AKT signaling pathway.\u00a0Neuropsychiatr Dis Treat\u00a01231\u20131242. https:\/\/doi.org\/10.2147\/NDT.S297975","DOI":"10.2147\/NDT.S297975"},{"issue":"64","key":"1543_CR60","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.bbi.2017.03.006","volume":"1","author":"H Rong","year":"2017","unstructured":"Rong H, Zhao Z, Feng J, Lei Y, Wu H, Sun R, Zhang Z, Hou B, Zhang W, Sun Y, Gu X (2017) The effects of dexmedetomidine pretreatment on the pro-and anti-inflammation systems after spinal cord injury in rats. Brain Behav Immun 1(64):195\u2013207. https:\/\/doi.org\/10.1016\/j.bbi.2017.03.006","journal-title":"Brain Behav Immun"},{"issue":"1","key":"1543_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-016-0767-2","volume":"14","author":"TC Saat","year":"2016","unstructured":"Saat TC, van den Akker EK, IJzermans, J.N., Dor, F.J. and de Bruin, R.W. (2016) Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? J Transl Med 14(1):1\u20139. https:\/\/doi.org\/10.1186\/s12967-016-0767-2","journal-title":"J Transl Med"},{"issue":"21","key":"1543_CR62","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009261","volume":"7","author":"M Shahid","year":"2018","unstructured":"Shahid M, Hermes EL, Chandra D, Tauseef M, Siddiqui MR, Faridi MH, Wu MX (2018) Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases. J Am Heart Assoc 7(21):e009261. https:\/\/doi.org\/10.1161\/JAHA.118.009261","journal-title":"J Am Heart Assoc"},{"key":"1543_CR63","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s11064-021-03418-7","volume":"46","author":"VK Sharma","year":"2021","unstructured":"Sharma VK, Singh TG, Singh S, Garg N, Dhiman S (2021) Apoptotic pathways and Alzheimer\u2019s disease: probing therapeutic potential. Neurochem Res 46:3103\u20133122. https:\/\/doi.org\/10.1007\/s11064-021-03418-7","journal-title":"Neurochem Res"},{"key":"1543_CR64","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.biopha.2017.08.125","volume":"95","author":"M Shen","year":"2017","unstructured":"Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL (2017) Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injury. Biomed Pharmacother 95:885\u2013893. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.125","journal-title":"Biomed Pharmacother"},{"key":"1543_CR65","doi-asserted-by":"publisher","unstructured":"Shen S, Ma L, Shao F, Jin L, Bian Z (2020) Long non-coding RNA (lncRNA) NEAT1 aggravates cerebral ischemia-reperfusion injury by suppressing the inhibitory effect of miR-214 on PTEN.\u00a0Med Sci Monit\u00a026:e924781\u20131. https:\/\/doi.org\/10.12659\/MSM.924781","DOI":"10.12659\/MSM.924781"},{"issue":"6","key":"1543_CR66","first-page":"6117","volume":"13","author":"W Shi","year":"2021","unstructured":"Shi W, Sun Y, Wang J, Tang Y, Zhou S, Xu Z, Yuan B, Geng X, Chen X (2021) Trem1 mediates neuronal apoptosis via interaction with SYK after spinal cord ischemia-reperfusion injury. American Journal of Translational Research 13(6):6117","journal-title":"American Journal of Translational Research"},{"key":"1543_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705080","volume":"12","author":"KA Shirey","year":"2021","unstructured":"Shirey KA, Blanco JC, Vogel SN (2021) Targeting TLR4 signaling to blunt viral-mediated acute lung injury. Front Immunol 12:705080. https:\/\/doi.org\/10.3389\/fimmu.2021.705080","journal-title":"Front Immunol"},{"issue":"10","key":"1543_CR68","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/v8100287","volume":"8","author":"KD Shives","year":"2016","unstructured":"Shives KD, Massey AR, May NA, Morrison TE, Beckham JD (2016) 4EBP-dependent signaling supports west nile virus growth and protein expression. Viruses 8(10):287. https:\/\/doi.org\/10.3390\/v8100287","journal-title":"Viruses"},{"key":"1543_CR69","doi-asserted-by":"publisher","unstructured":"Sionov RV, Vlahopoulos SA, Granot Z (2015) Regulation of Bim in health and disease.\u00a0Oncotarget\u00a06(27):23058. https:\/\/doi.org\/10.18632\/oncotarget.5492","DOI":"10.18632\/oncotarget.5492"},{"key":"1543_CR70","doi-asserted-by":"publisher","unstructured":"Sun A, Wang W, Ye X, Wang Y, Yang X, Ye Z, Sun X, Zhang C (2017) Protective effects of methane-rich saline on rats with lipopolysaccharide-induced acute lung injury.\u00a0Oxid Med Cell Long\u00a02017. https:\/\/doi.org\/10.1155\/2017\/7430193","DOI":"10.1155\/2017\/7430193"},{"issue":"2","key":"1543_CR71","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.yexcr.2019.02.002","volume":"376","author":"K Takahashi","year":"2019","unstructured":"Takahashi K, Itakura E, Takano K, Endo T (2019) DA-Raf, a dominant-negative regulator of the Ras\u2013ERK pathway, is essential for skeletal myocyte differentiation including myoblast fusion and apoptosis. Exp Cell Res 376(2):168\u2013180. https:\/\/doi.org\/10.1016\/j.yexcr.2019.02.002","journal-title":"Exp Cell Res"},{"key":"1543_CR72","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.brainresbull.2018.10.008","volume":"143","author":"BL Tang","year":"2018","unstructured":"Tang BL (2018) Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers. Brain Res Bull 143:123\u2013131. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.10.008","journal-title":"Brain Res Bull"},{"key":"1543_CR73","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283730","author":"GLQ Tang","year":"2020","unstructured":"Tang GLQ, Lai JXH, Pervaiz S (2020) Ubiquitin-proteasome pathway mediated regulation of Bcl-2 family: effects and therapeutic approaches. Haematologica. https:\/\/doi.org\/10.3324\/haematol.2023.283730","journal-title":"Haematologica"},{"key":"1543_CR74","doi-asserted-by":"publisher","unstructured":"Thapa K, Khan H, Kaur G, Kumar P, Singh TG (2023) Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development.\u00a0Biochem Biophys Res Commun 687:149130.https:\/\/doi.org\/10.1016\/j.bbrc.2023.149130","DOI":"10.1016\/j.bbrc.2023.149130"},{"key":"1543_CR75","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1007\/s11064-018-2538-3","volume":"43","author":"L Tu","year":"2018","unstructured":"Tu L, Wang Y, Chen D, Xiang P, Shen J, Li Y, Wang S (2018) Protective effects of notoginsenoside R1 via regulation of the PI3K-Akt-mTOR\/JNK pathway in neonatal cerebral hypoxic\u2013ischemic brain injury. Neurochem Res 43:1210\u20131226. https:\/\/doi.org\/10.1007\/s11064-018-2538-3","journal-title":"Neurochem Res"},{"issue":"7","key":"1543_CR76","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/cdd.2009.34","volume":"16","author":"JM Vicencio","year":"2009","unstructured":"Vicencio JM, Ortiz C, Criollo A, Jones AWE, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M (2009) The inositol 1, 4, 5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ 16(7):1006\u20131017. https:\/\/doi.org\/10.1038\/cdd.2009.34","journal-title":"Cell Death Differ"},{"key":"1543_CR77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00423-010-0727-x","volume":"396","author":"B Vollmar","year":"2011","unstructured":"Vollmar B, Menger MD (2011) Intestinal ischemia\/reperfusion: microcirculatory pathology and functional consequences. Langenbecks Arch Surg 396:13\u201329. https:\/\/doi.org\/10.1007\/s00423-010-0727-x","journal-title":"Langenbecks Arch Surg"},{"issue":"18","key":"1543_CR78","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1089\/neu.2018.6294","volume":"36","author":"CL Walker","year":"2019","unstructured":"Walker CL, Wu X, Liu NK, Xu XM (2019) Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K\/AKT-mTOR signaling after traumatic spinal injuries. J Neurotrauma 36(18):2676\u20132687. https:\/\/doi.org\/10.1089\/neu.2018.6294","journal-title":"J Neurotrauma"},{"key":"1543_CR79","doi-asserted-by":"publisher","unstructured":"Wang M, Zhang J, Gong N (2022) Role of the PI3K\/Akt signaling pathway in liver ischemia reperfusion injury: A narrative review.\u00a0Ann Palliat Med\u00a011(2):806\u2013817. https:\/\/doi.org\/10.21037\/apm-21-3286","DOI":"10.21037\/apm-21-3286"},{"key":"1543_CR80","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2022.10.101","volume":"638","author":"J Wei","year":"2023","unstructured":"Wei J, Cui J (2023) Mir-1322 protects against the myocardial ischemia Via Lrp8\/Pi3k\/Akt pathway. Biochem Biophys Res Commun 638:120\u2013126. https:\/\/doi.org\/10.1016\/j.bbrc.2022.10.101","journal-title":"Biochem Biophys Res Commun"},{"key":"1543_CR81","unstructured":"Wei L, Chen WY, Hu T, Tang YX, Pan BB, Jin M, Kong GY (2017) Effect and mechanism of propofol in hepatic ischemia\/reperfusion injury of rat.\u00a0Eur Rev Med Pharmacol Sci\u00a021(15)"},{"key":"1543_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2020.101947","volume":"64","author":"H Wen","year":"2020","unstructured":"Wen H, Zhang H, Wang W, Li Y (2020) Tetrahydropalmatine protects against acute lung injury induced by limb ischemia\/reperfusion through restoring PI3K\/AKT\/mTOR-mediated autophagy in rats. Pulm Pharmacol Ther 64:101947. https:\/\/doi.org\/10.1016\/j.pupt.2020.101947","journal-title":"Pulm Pharmacol Ther"},{"issue":"6","key":"1543_CR83","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/1440-1681.13274","volume":"47","author":"H Xiang","year":"2020","unstructured":"Xiang H, Xue W, Li Y, Zheng J, Ding C, Dou M, Wu X (2020) C1q\/TNF-related protein 6 (CTRP6) attenuates renal ischaemia-reperfusion injury through the activation of PI3K\/Akt signalling pathway. Clin Exp Pharmacol Physiol 47(6):1030\u20131040. https:\/\/doi.org\/10.1111\/1440-1681.13274","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1543_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175979","volume":"957","author":"X Xie","year":"2023","unstructured":"Xie X, Wang F, Ge W, Meng X, Fan L, Zhang W, Wang Z, Ding M, Gu S, Xing X, Sun X (2023) Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia\/reperfusion injury through PI3K\/Akt-mediated Nrf2 signaling pathways. Eur J Pharmacol 957:175979. https:\/\/doi.org\/10.1016\/j.ejphar.2023.175979","journal-title":"Eur J Pharmacol"},{"key":"1543_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109839","volume":"79","author":"D Xu","year":"2021","unstructured":"Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C (2021) Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK\/ERK\/mTOR pathway. Cell Signal 79:109839. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109839","journal-title":"Cell Signal"},{"issue":"5","key":"1543_CR86","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1042\/CS20150496","volume":"130","author":"R Xue","year":"2016","unstructured":"Xue R, Lei S, Xia ZY, Wu Y, Meng Q, Zhan L, Su W, Liu H, Xu J, Liu Z, Zhou B (2016) Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K\/Akt and JAK2\/STAT3 pathways. Clin Sci 130(5):377\u2013392. https:\/\/doi.org\/10.1042\/CS20150496","journal-title":"Clin Sci"},{"issue":"12","key":"1543_CR87","first-page":"2630","volume":"7","author":"J Yang","year":"2015","unstructured":"Yang J, Chen Q, Tian S, Song S, Liu F, Wang Q, Fu Z (2015) The role of 1, 25-dyhydroxyvitamin D3 in mouse liver ischemia reperfusion injury: regulation of autophagy through activation of MEK\/ERK signaling and PTEN\/PI3K\/Akt\/mTORC1 signaling. American Journal of Translational Research 7(12):2630","journal-title":"American Journal of Translational Research"},{"key":"1543_CR88","doi-asserted-by":"publisher","unstructured":"Yao W, Lin X, Han X, Zeng L, Guo A, Guan Y, Hei Z, Liu J, Huang P (2020) MicroRNA files in the prevention of intestinal ischemia\/reperfusion injury by hydrogen rich saline.\u00a0Biosci Rep\u00a040(1):BSR20191043. https:\/\/doi.org\/10.1042\/BSR20191043","DOI":"10.1042\/BSR20191043"},{"key":"1543_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.964771","volume":"13","author":"S Yi","year":"2022","unstructured":"Yi S, Tao X, Wang Y, Cao Q, Zhou Z, Wang S (2022) Effects of propofol on macrophage activation and function in diseases. Front Pharmacol 13:964771. https:\/\/doi.org\/10.3389\/fphar.2022.964771","journal-title":"Front Pharmacol"},{"key":"1543_CR90","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.lfs.2016.02.005","volume":"148","author":"QJ Yu","year":"2016","unstructured":"Yu QJ, Yang Y (2016) Function of SOD1, SOD2, and PI3K\/AKT signaling pathways in the protection of propofol on spinal cord ischemic reperfusion injury in a rabbit model. Life Sci 148:86\u201392. https:\/\/doi.org\/10.1016\/j.lfs.2016.02.005","journal-title":"Life Sci"},{"issue":"11","key":"1543_CR91","first-page":"4096","volume":"12","author":"J Zeng","year":"2019","unstructured":"Zeng J, Li X, Cheng Y, Ke B, Wang R (2019) Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K\/Akt pathway. Int J Clin Exp Pathol 12(11):4096","journal-title":"Int J Clin Exp Pathol"},{"key":"1543_CR92","doi-asserted-by":"publisher","unstructured":"Zeng S, Yuan S, Liu K (2023) Post\" Ischemic Treatment with Sevoflurane: To Reduce Myocardial Ischemic\/Reperfusion Injury in Rats by miR\" 26a\" 5p\/PTEN\/PI3K\/Akt Signaling https:\/\/doi.org\/10.17582\/journal.pjz\/20210806040858","DOI":"10.17582\/journal.pjz\/20210806040858"},{"key":"1543_CR93","doi-asserted-by":"publisher","unstructured":"Zhan JY, Zhang Y, Zhong X, Mao H, Chen XY, Li YF (2023) Liqi Huoxue dripping pill protects against myocardial ischemia-reperfusion injury via the PI3K\/Akt\/GSK-3\u03b2 signaling pathway in rats.\u00a0Tradit Med Res\u00a08(4):21 https:\/\/doi.org\/10.53388\/TMR20220903001","DOI":"10.53388\/TMR20220903001"},{"key":"1543_CR94","unstructured":"Zhang CY, Ren XM, Li HB, Wei W, Wang KX, Li YM, Hu JL, Li X (2019) Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN\/PI3K\/AKT signaling pathway.\u00a0Eur Rev Med Pharmacol Sci\u00a023(11)"},{"issue":"5","key":"1543_CR95","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.3892\/etm.2017.5166","volume":"14","author":"F Zhang","year":"2017","unstructured":"Zhang F, Ru N, Shang ZH, Chen JF, Yan C, Li Y, Liang J (2017) Daidzein ameliorates spinal cord ischemia\/reperfusion injury-induced neurological function deficits in Sprague-Dawley rats through PI3K\/Akt signaling pathway. Exp Ther Med 14(5):4878\u20134886. https:\/\/doi.org\/10.3892\/etm.2017.5166","journal-title":"Exp Ther Med"},{"key":"1543_CR96","doi-asserted-by":"publisher","unstructured":"Zhang P, Wang J, Wang X, Wang L, Xu S, Gong P (2023) Protectin D1 Alleviates Myocardial Ischemia\/Reperfusion Injury by Regulating PI3K\/AKT Signaling Pathway.\u00a0J Cardiovasc Transl Res\u00a01\u201312. https:\/\/doi.org\/10.1007\/s12265-023-10426-1","DOI":"10.1007\/s12265-023-10426-1"},{"issue":"3","key":"1543_CR97","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.febslet.2006.12.055","volume":"581","author":"QG Zhang","year":"2007","unstructured":"Zhang QG, Wu DN, Han D, Zhang GY (2007) Critical role of PTEN in the coupling between PI3K\/Akt and JNK1\/2 signaling in ischemic brain injury. FEBS Lett 581(3):495\u2013505. https:\/\/doi.org\/10.1016\/j.febslet.2006.12.055","journal-title":"FEBS Lett"},{"key":"1543_CR98","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.freeradbiomed.2021.03.038","volume":"168","author":"W Zhang","year":"2021","unstructured":"Zhang W, Cheng C, Sha Z, Chen C, Yu C, Lv N, Ji P, Wu X, Ma T, Cheng H, Shi L (2021a) Rosmarinic acid prevents refractory bacterial pneumonia through regulating Keap1\/Nrf2-mediated autophagic pathway and mitochondrial oxidative stress. Free Radical Biol Med 168:247\u2013257. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.03.038","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"1543_CR99","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J (2021b) mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun 12(1):1589. https:\/\/doi.org\/10.1038\/s41467-021-21841-w","journal-title":"Nat Commun"},{"key":"1543_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.610587","volume":"8","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Wang J, Yang B, Qiao R, Li A, Guo H, Ding J, Li H, Ye H, Wu D, Cui L (2020) Transfer of microRNA-216a-5p from exosomes secreted by human urine-derived stem cells reduces renal ischemia\/reperfusion injury. Frontiers in Cell and Developmental Biology 8:610587. https:\/\/doi.org\/10.3389\/fcell.2020.610587","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"3","key":"1543_CR101","first-page":"1311","volume":"11","author":"H Zhu","year":"2019","unstructured":"Zhu H, Wang Y, Yang X, Wan G, Qiu Y, Ye X, Gao Y, Wan D (2019) Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt\/mTOR pathway and regulating BDNF and PTEN expression. American Journal of Translational Research 11(3):1311","journal-title":"American Journal of Translational Research"},{"key":"1543_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105898","volume":"76","author":"SF Zi","year":"2019","unstructured":"Zi SF, Li JH, Liu L, Deng C, Ao X, Chen DD, Wu SZ (2019) Dexmedetomidine-mediated protection against septic liver injury depends on TLR4\/MyD88\/NF-\u03baB signaling downregulation partly via cholinergic anti-inflammatory mechanisms. Int Immunopharmacol 76:105898. https:\/\/doi.org\/10.1016\/j.intimp.2019.105898","journal-title":"Int Immunopharmacol"},{"key":"1543_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121045","volume":"309","author":"Z Zou","year":"2022","unstructured":"Zou Z, Wang Z (2022) Liraglutide attenuates intestinal ischemia\/reperfusion injury via NF-\u03baB and PI3K\/Akt pathways in mice. Life Sci 309:121045. https:\/\/doi.org\/10.1016\/j.lfs.2022.121045","journal-title":"Life Sci"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-025-01543-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T19:31:53Z","timestamp":1743103913000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-025-01543-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":103,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["1543"],"URL":"https:\/\/doi.org\/10.1007\/s11011-025-01543-8","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and given their consent for the final manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"131"}}