{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:28:45Z","timestamp":1772119725927,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Naval Medical University basic medical research project","award":["2022QN015"],"award-info":[{"award-number":["2022QN015"]}]},{"name":"Major project of Brain Science and Brain-like Research","award":["2022ZD0208100"],"award-info":[{"award-number":["2022ZD0208100"]}]},{"name":"Young scientists fond of the National Natural Science Foundation of China","award":["81901913"],"award-info":[{"award-number":["81901913"]}]},{"name":"Naval Medical University project","award":["2023MS008"],"award-info":[{"award-number":["2023MS008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-025-01630-w","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:06:20Z","timestamp":1747371980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-9576","authenticated-orcid":false,"given":"Mengyu","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6962-7707","authenticated-orcid":false,"given":"Shuang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengfeng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"issue":"3","key":"1630_CR1","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.nlm.2010.08.007","volume":"94","author":"JH Baek","year":"2010","unstructured":"Baek JH, Zheng Y, Darlington CL, Smith PF (2010) Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiol Learn Mem 94(3):402\u2013413. https:\/\/doi.org\/10.1016\/j.nlm.2010.08.007","journal-title":"Neurobiol Learn Mem"},{"key":"1630_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00019052-199902000-00005","volume":"12","author":"CD Balaban","year":"1999","unstructured":"Balaban CD (1999) Vestibular autonomic regulation (including motion sickness and the mechanism of vomiting). Curr Opin Neurol 12:29\u201333. https:\/\/doi.org\/10.1097\/00019052-199902000-00005","journal-title":"Curr Opin Neurol"},{"key":"1630_CR3","doi-asserted-by":"publisher","first-page":"R807","DOI":"10.1152\/ajpregu.00276.2012","volume":"303","author":"CB Blake","year":"2012","unstructured":"Blake CB, Smith BN (2012) Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus. Am J Physiol Regul Integr Comp Physiol 303:R807-814. https:\/\/doi.org\/10.1152\/ajpregu.00276.2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1630_CR4","doi-asserted-by":"publisher","first-page":"e10752","DOI":"10.1371\/journal.pone.0010752","volume":"5","author":"A Chouk\u00e8r","year":"2010","unstructured":"Chouk\u00e8r A, Kaufmann I, Kreth S, Hauer D, Feuerecker M, Thieme D, Vogeser M, Thiel M, Schelling G (2010) Motion sickness, stress and the endocannabinoid system. PLoS ONE 5:e10752. https:\/\/doi.org\/10.1371\/journal.pone.0010752","journal-title":"PLoS ONE"},{"key":"1630_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1037\/a0024097","volume":"17","author":"X Dong","year":"2011","unstructured":"Dong X, Yoshida K, Stoffregen TA (2011) Control of a virtual vehicle influences postural activity and motion sickness. J Exp Psychol Appl 17:128\u2013138. https:\/\/doi.org\/10.1037\/a0024097","journal-title":"J Exp Psychol Appl"},{"key":"1630_CR6","first-page":"229","volume":"5","author":"WL Farrar","year":"1989","unstructured":"Farrar WL, Ferris DK, Harel-Bellan A (1989) The molecular basis of immune cytokine action. Crit Rev Ther Drug Carrier Syst 5:229\u2013261","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"1630_CR7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/jnc.13909","volume":"140","author":"M Gralle","year":"2017","unstructured":"Gralle M (2017) The neuronal insulin receptor in its environment. J Neurochem 140:359\u2013367. https:\/\/doi.org\/10.1111\/jnc.13909","journal-title":"J Neurochem"},{"key":"1630_CR8","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1091\/mbc.E12-05-0337","volume":"23","author":"A Gupta","year":"2012","unstructured":"Gupta A, Dey CS (2012) PTEN, a widely known negative regulator of insulin\/PI3K signaling, positively regulates neuronal insulin resistance. Mol Biol Cell 23:3882\u20133898. https:\/\/doi.org\/10.1091\/mbc.E12-05-0337","journal-title":"Mol Biol Cell"},{"key":"1630_CR9","doi-asserted-by":"publisher","first-page":"763040","DOI":"10.3389\/fnins.2021.763040","volume":"15","author":"T Harada","year":"2021","unstructured":"Harada T, Sugawara T, Ito T, Wada Y, Fukunaga M, Sadato N, Larroque SK, Demertzi A, Laureys S, Sakai H (2021) Vestibular morphological asymmetry associated with motion sickness susceptibility. Front Neurosci 15:763040. https:\/\/doi.org\/10.3389\/fnins.2021.763040","journal-title":"Front Neurosci"},{"key":"1630_CR10","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1091\/mbc.E12-05-0337","volume":"29","author":"K Hashimoto","year":"2005","unstructured":"Hashimoto K, Engberg G, Shimizu E, Nordin C, Lindstrom LH, Iyo M (2005) Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 29:767\u2013769. https:\/\/doi.org\/10.1091\/mbc.E12-05-0337","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1630_CR11","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cmet.2010.03.002","volume":"11","author":"JW Hill","year":"2010","unstructured":"Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Br\u00fcning JC, Elmquist JK (2010) Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab 11:286\u2013297. https:\/\/doi.org\/10.1016\/j.cmet.2010.03.002","journal-title":"Cell Metab"},{"key":"1630_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fnint.2014.00059","volume":"8","author":"M Hitier","year":"2014","unstructured":"Hitier M, Besnard S, Smith PF (2014) Vestibular pathways involved in cognition. Front Integr Neurosci 8:59. https:\/\/doi.org\/10.3389\/fnint.2014.00059","journal-title":"Front Integr Neurosci"},{"key":"1630_CR13","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1259\/0007-1285-50-597-645","volume":"50","author":"EV Hulse","year":"1977","unstructured":"Hulse EV, Patrick G (1977) A model for treating post-irradiation nausea and vomiting in man: the action of insulin in abolishing radiation-induced delay in gastric emptying in the rat. Br J Radiol 50:645\u2013651. https:\/\/doi.org\/10.1259\/0007-1285-50-597-645","journal-title":"Br J Radiol"},{"key":"1630_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.redox.2016.10.004","volume":"10","author":"N Jia","year":"2016","unstructured":"Jia N, Sun Q, Su Q, Dang S, Chen G (2016) Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1alpha pathway. Redox Biol 10:179\u2013190. https:\/\/doi.org\/10.1016\/j.redox.2016.10.004","journal-title":"Redox Biol"},{"issue":"1","key":"1630_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/WCO.0000000000001018","volume":"35","author":"B Keshavarz","year":"2022","unstructured":"Keshavarz B, Golding JF (2022) Motion sickness: current concepts and management. Curr Opin Neurol 35(1):107\u2013112. https:\/\/doi.org\/10.1097\/WCO.0000000000001018","journal-title":"Curr Opin Neurol"},{"key":"1630_CR16","doi-asserted-by":"publisher","first-page":"G964","DOI":"10.1152\/ajpgi.1998.275.5.G964","volume":"275","author":"ZK Krowicki","year":"1998","unstructured":"Krowicki ZK, Nathan NA, Hornby PJ (1998) Gastric motor and cardiovascular effects of insulin in dorsal vagal complex of the rat. Am J Physiol 275:G964-972. https:\/\/doi.org\/10.1152\/ajpgi.1998.275.5.G964","journal-title":"Am J Physiol"},{"issue":"8","key":"1630_CR17","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1177\/0018720819876139","volume":"62","author":"OX Kuiper","year":"2020","unstructured":"Kuiper OX, Bos JE, Schmidt EA, Diels C, Wolter S (2020) Knowing what\u2019s coming: unpredictable motion causes more motion sickness. Hum Factors 62(8):1339\u20131348. https:\/\/doi.org\/10.1177\/0018720819876139","journal-title":"Hum Factors"},{"key":"1630_CR18","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.1210\/jc.2009-2514","volume":"95","author":"P Kuo","year":"2010","unstructured":"Kuo P, Wishart JM, Bellon M, Smout AJ, Holloway RH, Fraser RJ, Horowitz M, Jones KL, Rayner CK (2010) Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans. J Clin Endocrinol Metab 95:3893\u20133900. https:\/\/doi.org\/10.1210\/jc.2009-2514","journal-title":"J Clin Endocrinol Metab"},{"key":"1630_CR19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00221-006-0697-y","volume":"175","author":"JR Lackner","year":"2006","unstructured":"Lackner JR, Dizio P (2006) Space motion sickness. Exp Brain Res 175:377\u2013399. https:\/\/doi.org\/10.1007\/s00221-006-0697-y","journal-title":"Exp Brain Res"},{"key":"1630_CR20","first-page":"675","volume":"54","author":"JR Lackner","year":"1983","unstructured":"Lackner JR, Graybiel A (1983) Etiological factors in space motion sickness. Aviat Space Environ Med 54:675\u2013681","journal-title":"Aviat Space Environ Med"},{"key":"1630_CR21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/b978-0-12-027310-2.50017-7","volume":"10","author":"D Le Roith","year":"1983","unstructured":"Le Roith D, Hendricks SA, Lesniak MA, Rishi S, Becker KL, Havrankova J, Rosenzweig JL, Brownstein MJ, Roth J (1983) Insulin in brain and other extrapancreatic tissues of vertebrates and nonvertebrates. Adv Metab Disord 10:303\u2013340. https:\/\/doi.org\/10.1016\/b978-0-12-027310-2.50017-7","journal-title":"Adv Metab Disord"},{"key":"1630_CR22","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1159\/000088991","volume":"81","author":"X Li","year":"2005","unstructured":"Li X, Jiang ZL, Wang GH, Fan JW (2005) Plasma vasopressin, an etiologic factor of motion sickness in rat and human? Neuroendocrinology 81:351\u2013359. https:\/\/doi.org\/10.1159\/000088991","journal-title":"Neuroendocrinology"},{"key":"1630_CR23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1017\/S000711450769936X","volume":"98","author":"P Li","year":"2007","unstructured":"Li P, Yin YL, Li D, Kim SW, Wu G (2007) Amino acids and immune function. Br J Nutr 98:237\u2013252. https:\/\/doi.org\/10.1017\/S000711450769936X","journal-title":"Br J Nutr"},{"key":"1630_CR24","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1053\/j.gastro.2007.06.060","volume":"133","author":"TJ Little","year":"2007","unstructured":"Little TJ, Russo A, Meyer JH, Horowitz M, Smyth DR, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C (2007) Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology 133:1124\u20131131. https:\/\/doi.org\/10.1053\/j.gastro.2007.06.060","journal-title":"Gastroenterology"},{"key":"1630_CR25","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/ki.2010.526","volume":"79","author":"A Mima","year":"2011","unstructured":"Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL (2011) Glomerular-specific protein kinase C-beta-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int 79:883\u2013896. https:\/\/doi.org\/10.1038\/ki.2010.526","journal-title":"Kidney Int"},{"key":"1630_CR26","doi-asserted-by":"publisher","unstructured":"Mo F, Zhang H, Tang Y, Qi R, Nie S, Shen H, Li M (2021) Pyruvate accumulation may contribute to acceleration-induced impairment of physical and cognitive abilities: an experimental study. Biosci Rep 41(4):BSR20204284. https:\/\/doi.org\/10.1042\/BSR20204284","DOI":"10.1042\/BSR20204284"},{"key":"1630_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.expneurol.2013.03.007","volume":"247","author":"AP Muller","year":"2013","unstructured":"Muller AP, Haas CB, Camacho-Pereira J, Brochier AW, Gnoatto J, Zimmer ER, de Souza DO, Galina A, Portela LV (2013) Insulin prevents mitochondrial generation of H2O2 in rat brain. Exp Neurol 247:66\u201372. https:\/\/doi.org\/10.1016\/j.expneurol.2013.03.007","journal-title":"Exp Neurol"},{"key":"1630_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11938-003-0022-9","volume":"6","author":"D O'Donovan","year":"2003","unstructured":"O\u2019Donovan D, Feinle-Bisset C, Jones K, Horowitz M (2003) Idiopathic and diabetic gastroparesis. Curr Treat Options Gastroenterol 6:299\u2013309. https:\/\/doi.org\/10.1007\/s11938-003-0022-9","journal-title":"Curr Treat Options Gastroenterol"},{"key":"1630_CR29","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1177\/014107687807101109","volume":"71","author":"JT Reason","year":"1978","unstructured":"Reason JT (1978) Motion sickness adaptation: a neural mismatch model. J R Soc Med 71:819\u2013829. https:\/\/doi.org\/10.1177\/014107687807101109","journal-title":"J R Soc Med"},{"key":"1630_CR30","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1210\/jc.2005-0513","volume":"90","author":"A Russo","year":"2005","unstructured":"Russo A, Stevens JE, Chen R, Gentilcore D, Burnet R, Horowitz M, Jones KL (2005) Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes. J Clin Endocrinol Metab 90:4489\u20134495. https:\/\/doi.org\/10.1210\/jc.2005-0513","journal-title":"J Clin Endocrinol Metab"},{"key":"1630_CR31","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1007\/s00125-011-2282-6","volume":"54","author":"D Sharma","year":"2011","unstructured":"Sharma D, Morrison G, Joseph F, Purewal TS, Weston PJ (2011) The role of continuous subcutaneous insulin infusion therapy in patients with diabetic gastroparesis. Diabetologia 54:2768\u20132770. https:\/\/doi.org\/10.1007\/s00125-011-2282-6","journal-title":"Diabetologia"},{"issue":"3","key":"1630_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/acupmed-2016-011202","volume":"36","author":"D Tian","year":"2018","unstructured":"Tian D, Mo F, Cai X, Miao Z, Xiao F, Chang Y, Wu L, Tang Y, Wang X, Ye C, Qian X, Gu W, Li M (2018) Acupuncture relieves motion sickness via the IRbeta-ERK1\/2-dependent insulin receptor signalling pathway. Acupunct Med 36(3):153\u2013161. https:\/\/doi.org\/10.1136\/acupmed-2016-011202","journal-title":"Acupunct Med"},{"key":"1630_CR33","doi-asserted-by":"publisher","unstructured":"Tom J, Keith S, Marinus D, Ruud B, Bwee-Tien, Robert S (2003) L-serine in disease and development. Biochem J 371:653-661.https:\/\/doi.org\/10.1042\/BJ20021785","DOI":"10.1042\/BJ20021785"},{"key":"1630_CR34","doi-asserted-by":"publisher","first-page":"G1050","DOI":"10.1152\/ajpgi.90288.2008","volume":"295","author":"S Wan","year":"2008","unstructured":"Wan S, Browning KN (2008) Glucose increases synaptic transmission from vagal afferent central nerve terminals via modulation of 5-HT3 receptors. Am J Physiol. Gastrointest Liver Physiol 295:G1050\u2013G1057. https:\/\/doi.org\/10.1152\/ajpgi.90288.2008","journal-title":"Am J Physiol. Gastrointest Liver Physiol"},{"key":"1630_CR35","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1021\/pr801086k","volume":"8","author":"X Wang","year":"2009","unstructured":"Wang X, Zhao T, Qiu Y, Su M, Jiang T, Zhou M, Zhao A, Jia W (2009) Metabonomics approach to understanding acute and chronic stress in rat models. J Proteome Res 8:2511\u20132518. https:\/\/doi.org\/10.1021\/pr801086k","journal-title":"J Proteome Res"},{"key":"1630_CR36","doi-asserted-by":"publisher","first-page":"43385","DOI":"10.1038\/srep43385","volume":"7","author":"J Wang","year":"2017","unstructured":"Wang J, Liu J, Pan L, Qi R, Liu P, Zhou W, Cai Y (2017a) Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII\/CREB signaling pathway in a motion sickness rodent model. Sci Rep 7:43385. https:\/\/doi.org\/10.1038\/srep43385","journal-title":"Sci Rep"},{"key":"1630_CR37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jprot.2017.03.013","volume":"160","author":"T Wang","year":"2017","unstructured":"Wang T, Chen H, Lv K, Ji G, Zhang Y, Wang Y, Li Y, Qu L (2017b) iTRAQ-based proteomics analysis of hippocampus in spatial memory deficiency rats induced by simulated microgravity. J Proteomics 160:64\u201373. https:\/\/doi.org\/10.1016\/j.jprot.2017.03.013","journal-title":"J Proteomics"},{"key":"1630_CR38","doi-asserted-by":"publisher","first-page":"13409","DOI":"10.1073\/pnas.96.23.13409","volume":"96","author":"H Wolosker","year":"1999","unstructured":"Wolosker H, Blackshaw S, Snyder SH (1999) Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci USA 96:13409\u201313414. https:\/\/doi.org\/10.1073\/pnas.96.23.13409","journal-title":"Proc Natl Acad Sci USA"},{"key":"1630_CR39","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/cpt1970115621","volume":"11","author":"CD Wood","year":"1970","unstructured":"Wood CD, Graybiel A (1970) A theory of motion sickness based on pharmacological reactions. Clin Pharmacol Ther 11:621\u2013629. https:\/\/doi.org\/10.1002\/cpt1970115621","journal-title":"Clin Pharmacol Ther"},{"key":"1630_CR40","doi-asserted-by":"publisher","first-page":"118159","DOI":"10.1016\/j.lfs.2020.118159","volume":"259","author":"L Yang","year":"2020","unstructured":"Yang L, Zhang X, Li S, Wang H, Zhang X, Liu L, Xie A (2020) Intranasal insulin ameliorates cognitive impairment in a rat model of Parkinson\u2019s disease through Akt\/GSK3\u03b2 signaling pathway. Life Sci 259:118159. https:\/\/doi.org\/10.1016\/j.lfs.2020.118159","journal-title":"Life Sci"},{"key":"1630_CR41","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.physbeh.2007.05.067","volume":"92","author":"XH Yu","year":"2007","unstructured":"Yu XH, Cai GJ, Liu AJ, Chu ZX, Su DF (2007) A novel animal model for motion sickness and its first application in rodents. Physiol Behav 92:702\u2013707. https:\/\/doi.org\/10.1016\/j.physbeh.2007.05.067","journal-title":"Physiol Behav"},{"key":"1630_CR42","doi-asserted-by":"publisher","first-page":"21186","DOI":"10.1038\/srep21186","volume":"6","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Dai CL, Chen Y, Iqbal K, Liu F, Gong CX (2016) Intranasal insulin prevents anesthesia-induced spatial learning and memory deficit in mice. Sci Rep 6:21186. https:\/\/doi.org\/10.1038\/srep21186","journal-title":"Sci Rep"},{"key":"1630_CR43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ejphar.2014.01.047","volume":"727","author":"Y Zheng","year":"2014","unstructured":"Zheng Y, Wang XL, Mo FF, Li M (2014) Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. Eur J Pharmacol 727:99\u2013105. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.047","journal-title":"Eur J Pharmacol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01630-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-025-01630-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01630-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:24:25Z","timestamp":1750901065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-025-01630-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["1630"],"URL":"https:\/\/doi.org\/10.1007\/s11011-025-01630-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4469299\/v1","asserted-by":"object"}]},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"24 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"203"}}