{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:08:18Z","timestamp":1789168098107,"version":"build-2803163510"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474289"],"award-info":[{"award-number":["82474289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Provincial Natural Science Foundation Joint Guidance Project","award":["LH2023H071"],"award-info":[{"award-number":["LH2023H071"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-025-01707-6","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:52:53Z","timestamp":1760172773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Promotion of angiogenesis in cerebral infarction by Tongqiao Huoxue Decoction through activation of glycolysis"],"prefix":"10.1007","volume":"40","author":[{"given":"Xintong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongda","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-5827","authenticated-orcid":false,"given":"Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-089X","authenticated-orcid":false,"given":"Peiliang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"1707_CR1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2174\/092986712803413944","volume":"19","author":"A Ahluwalia","year":"2012","unstructured":"Ahluwalia A, Tarnawski AS (2012) Critical role of hypoxia sensor-HIF-1\u03b1 in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr Med Chem 19:90\u201397. https:\/\/doi.org\/10.2174\/092986712803413944","journal-title":"Curr Med Chem"},{"key":"1707_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111779","author":"SR Archie","year":"2021","unstructured":"Archie SR, Al Shoyaib A, Cucullo L (2021) Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics13111779","journal-title":"Pharmaceutics"},{"key":"1707_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.012","volume":"1866","author":"D Barthels","year":"2020","unstructured":"Barthels D, Das H (2020) Current advances in ischemic stroke research and therapies. Biochim Biophys Acta Mol Basis Dis 1866:165260. https:\/\/doi.org\/10.1016\/j.bbadis.2018.09.012","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1707_CR4","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1046\/j.1460-9568.1999.00845.x","volume":"11","author":"M Bergeron","year":"1999","unstructured":"Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR (1999) Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11:4159\u20134170. https:\/\/doi.org\/10.1046\/j.1460-9568.1999.00845.x","journal-title":"Eur J Neurosci"},{"key":"1707_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914848","author":"A Bersano","year":"2023","unstructured":"Bersano A, Gatti L (2023) Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241914848","journal-title":"Int J Mol Sci"},{"key":"1707_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.716825","volume":"15","author":"S Chen","year":"2021","unstructured":"Chen S, Shao L, Ma L (2021) Cerebral edema formation after stroke: emphasis on blood-brain barrier and the lymphatic drainage system of the brain. Front Cell Neurosci 15:716825. https:\/\/doi.org\/10.3389\/fncel.2021.716825","journal-title":"Front Cell Neurosci"},{"key":"1707_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1042\/bst20200611","volume":"49","author":"AM Clyne","year":"2021","unstructured":"Clyne AM (2021) Endothelial response to glucose: dysfunction, metabolism, and transport. Biochem Soc Trans 49:313\u2013325. https:\/\/doi.org\/10.1042\/bst20200611","journal-title":"Biochem Soc Trans"},{"key":"1707_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S et al (2013) Role of pfkfb3-driven glycolysis in vessel sprouting. Cell 154:651\u2013663. https:\/\/doi.org\/10.1016\/j.cell.2013.06.037","journal-title":"Cell"},{"key":"1707_CR9","doi-asserted-by":"publisher","first-page":"23001","DOI":"10.1038\/s41598-025-03515-5","volume":"15","author":"X Deng","year":"2025","unstructured":"Deng X, Leng Y, Xiong Y et al (2025) Circadian gene BMAL1 ameliorates renal ischaemia-reperfusion injury in diabetic mice by enhancing mitophagy via the HIF-1\/BNIP3 pathway. Sci Rep 15:23001. https:\/\/doi.org\/10.1038\/s41598-025-03515-5","journal-title":"Sci Rep"},{"key":"1707_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1242\/dmm.010413","volume":"6","author":"G Dragneva","year":"2013","unstructured":"Dragneva G, Korpisalo P, Yl\u00e4-Herttuala S (2013) Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success. Dis Model Mech 6:312\u2013322. https:\/\/doi.org\/10.1242\/dmm.010413","journal-title":"Dis Model Mech"},{"key":"1707_CR11","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170219","author":"N Draoui","year":"2017","unstructured":"Draoui N, de Zeeuw P, Carmeliet P (2017) Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism. Open Biol. https:\/\/doi.org\/10.1098\/rsob.170219","journal-title":"Open Biol"},{"key":"1707_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020147","author":"W Du","year":"2021","unstructured":"Du W, Ren L, Hamblin MH, Fan Y (2021) Endothelial cell glucose metabolism and angiogenesis. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines9020147","journal-title":"Biomedicines"},{"key":"1707_CR13","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.116.302855","volume":"116","author":"G Eelen","year":"2015","unstructured":"Eelen G, de Zeeuw P, Simons M, Carmeliet P (2015) Endothelial cell metabolism in normal and diseased vasculature. Circ Res 116:1231\u20131244. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.302855","journal-title":"Circ Res"},{"key":"1707_CR14","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41401-023-01061-2","volume":"44","author":"J Fang","year":"2023","unstructured":"Fang J, Wang Z, Miao CY (2023) Angiogenesis after ischemic stroke. Acta Pharmacol Sin 44:1305\u20131321. https:\/\/doi.org\/10.1038\/s41401-023-01061-2","journal-title":"Acta Pharmacol Sin"},{"key":"1707_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126592","author":"A Fazio","year":"2024","unstructured":"Fazio A, Neri I, Koufi FD et al (2024) Signaling role of pericytes in vascular health and tissue homeostasis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25126592","journal-title":"Int J Mol Sci"},{"key":"1707_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051362","author":"SJ Geiseler","year":"2018","unstructured":"Geiseler SJ, Morland C (2018) The janus face of VEGF in stroke. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19051362","journal-title":"Int J Mol Sci"},{"key":"1707_CR17","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1007\/s00018-013-1539-2","volume":"71","author":"LR Gray","year":"2014","unstructured":"Gray LR, Tompkins SC, Taylor EB (2014) Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci 71:2577\u20132604. https:\/\/doi.org\/10.1007\/s00018-013-1539-2","journal-title":"Cell Mol Life Sci"},{"key":"1707_CR18","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1007\/s11357-024-01429-0","volume":"47","author":"F Gy\u0151ri","year":"2025","unstructured":"Gy\u0151ri F, M\u00e9sz\u00e1ros \u00c1, Krecsmarik M et al (2025) Expression of alpha smooth muscle actin decreases with ageing and increases upon lumen obstruction in mouse brain pericytes. Geroscience 47:2525\u20132540. https:\/\/doi.org\/10.1007\/s11357-024-01429-0","journal-title":"Geroscience"},{"key":"1707_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/iub.572","volume":"64","author":"AP Halestrap","year":"2012","unstructured":"Halestrap AP, Wilson MC (2012) The monocarboxylate transporter family\u2013role and regulation. IUBMB Life 64:109\u2013119. https:\/\/doi.org\/10.1002\/iub.572","journal-title":"IUBMB Life"},{"key":"1707_CR20","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/15257770.2024.2379321","volume":"43","author":"G Harasim","year":"2024","unstructured":"Harasim G, Fra\u0144czak MA, Minutolo F et al (2024) Effects of lactate dehydrogenase A and GLUT1 inhibition on human endothelial cell migration in relation to their intracellular nucleotide pool. Nucleosides Nucleotides Nucleic Acids 43:761\u2013769. https:\/\/doi.org\/10.1080\/15257770.2024.2379321","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"1707_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.801985","volume":"12","author":"Q He","year":"2021","unstructured":"He Q, Ma Y, Liu J et al (2021) Biological functions and regulatory mechanisms of Hypoxia-inducible factor-1\u03b1 in ischemic stroke. Front Immunol 12:801985. https:\/\/doi.org\/10.3389\/fimmu.2021.801985","journal-title":"Front Immunol"},{"key":"1707_CR22","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.2147\/jir.S461427","volume":"17","author":"B Hu","year":"2024","unstructured":"Hu B, Pei J, Wan C et al (2024) Mechanisms of postischemic stroke angiogenesis: a multifaceted approach. J Inflamm Res 17:4625\u20134646. https:\/\/doi.org\/10.2147\/jir.S461427","journal-title":"J Inflamm Res"},{"key":"1707_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216074","volume":"556","author":"Z Jiang","year":"2023","unstructured":"Jiang Z, Zhou J, Li L et al (2023) Pericytes in the tumor microenvironment. Cancer Lett 556:216074. https:\/\/doi.org\/10.1016\/j.canlet.2023.216074","journal-title":"Cancer Lett"},{"key":"1707_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1113\/jp280572","volume":"599","author":"SJ Kierans","year":"2021","unstructured":"Kierans SJ, Taylor CT (2021) Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol 599:23\u201337. https:\/\/doi.org\/10.1113\/jp280572","journal-title":"J Physiol"},{"key":"1707_CR25","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.1007\/s12035-022-02778-7","volume":"59","author":"ES Kim","year":"2022","unstructured":"Kim ES, Kim KS, Lee CH et al (2022) Brain endothelial cells utilize glycolysis for the maintenance of the transcellular permeability. Mol Neurobiol 59:4315\u20134333. https:\/\/doi.org\/10.1007\/s12035-022-02778-7","journal-title":"Mol Neurobiol"},{"key":"1707_CR26","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","volume":"472","author":"H Koepsell","year":"2020","unstructured":"Koepsell H (2020) Glucose transporters in brain in health and disease. Pfl\u00fcgers Arch Eur J Physiol 472:1299\u20131343. https:\/\/doi.org\/10.1007\/s00424-020-02441-x","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"key":"1707_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.37349\/etat.2024.00210","volume":"5","author":"T Koltai","year":"2024","unstructured":"Koltai T, Fliegel L (2024) Exploring monocarboxylate transporter inhibition for cancer treatment. Exploration of Targeted Anti-Tumor Therapy 5:135\u2013169. https:\/\/doi.org\/10.37349\/etat.2024.00210","journal-title":"Exploration of Targeted Anti-Tumor Therapy"},{"key":"1707_CR28","doi-asserted-by":"publisher","first-page":"S277","DOI":"10.33549\/physiolres.934996","volume":"71","author":"P Kozler","year":"2022","unstructured":"Kozler P, Mare\u0161ov\u00e1 D, Pokorn\u00fd J (2022) Determination of brain water content by dry\/wet weight measurement for the detection of experimental brain edema. Physiol Res 71:S277\u2013S283. https:\/\/doi.org\/10.33549\/physiolres.934996","journal-title":"Physiol Res"},{"key":"1707_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2023.102281","volume":"11","author":"K Krishnan","year":"2023","unstructured":"Krishnan K, Saion E, Halimah MK, Yap CK (2023) Utilizing mollusk soft tissue and shells as biomarkers for monitoring heavy metal pollution in mangrove forests. MethodsX 11:102281. https:\/\/doi.org\/10.1016\/j.mex.2023.102281","journal-title":"MethodsX"},{"key":"1707_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.4103\/0973-029x.125200","volume":"17","author":"I Kukreja","year":"2013","unstructured":"Kukreja I, Kapoor P, Deshmukh R, Kulkarni V (2013) VEGF and CD 34: a correlation between tumor angiogenesis and microvessel density-an immunohistochemical study. J Oral Maxillofac Pathol 17:367\u2013373. https:\/\/doi.org\/10.4103\/0973-029x.125200","journal-title":"J Oral Maxillofac Pathol"},{"key":"1707_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/nyas.14798","volume":"1514","author":"WT Kuo","year":"2022","unstructured":"Kuo WT, Odenwald MA, Turner JR, Zuo L (2022) Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival. Ann N Y Acad Sci 1514:21\u201333. https:\/\/doi.org\/10.1111\/nyas.14798","journal-title":"Ann N Y Acad Sci"},{"key":"1707_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207609","author":"D Kuriakose","year":"2020","unstructured":"Kuriakose D, Xiao Z (2020) Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21207609","journal-title":"Int J Mol Sci"},{"key":"1707_CR33","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.2147\/dddt.S426345","volume":"17","author":"X Li","year":"2023","unstructured":"Li X, Liu R, Liu W et al (2023) Panax quinquefolium L. and Salvia miltiorrhiza Bunge. enhances angiogenesis by regulating the miR-155-5p\/HIF-1\u03b1\/VEGF axis in acute myocardial infarction. Drug des Devel Ther 17:3249\u20133267. https:\/\/doi.org\/10.2147\/dddt.S426345","journal-title":"Drug des Devel Ther"},{"key":"1707_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1167\/iovs.66.1.58","volume":"66","author":"D Liao","year":"2025","unstructured":"Liao D, Wang J, Zhang X, Li R, Yang X (2025) Eno2-regulated glycolysis in endothelial cells contributes to FGF2-induced retinal neovascularization. Invest Ophthalmol vis Sci 66:58. https:\/\/doi.org\/10.1167\/iovs.66.1.58","journal-title":"Invest Ophthalmol vis Sci"},{"key":"1707_CR35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jare.2024.05.001","volume":"70","author":"Y Liu","year":"2025","unstructured":"Liu Y, Wu Z, Li Y et al (2025) Metabolic reprogramming and interventions in angiogenesis. J Adv Res 70:323\u2013338. https:\/\/doi.org\/10.1016\/j.jare.2024.05.001","journal-title":"J Adv Res"},{"key":"1707_CR36","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.7150\/thno.88223","volume":"14","author":"S Madai","year":"2024","unstructured":"Madai S, Kilic P, Schmidt RM et al (2024) Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism. Theranostics 14:2856\u20132880. https:\/\/doi.org\/10.7150\/thno.88223","journal-title":"Theranostics"},{"key":"1707_CR37","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/978-3-319-55330-6_21","volume":"982","author":"R Marcu","year":"2017","unstructured":"Marcu R, Zheng Y, Hawkins BJ (2017) Mitochondria and angiogenesis. Adv Exp Med Biol 982:371\u2013406. https:\/\/doi.org\/10.1007\/978-3-319-55330-6_21","journal-title":"Adv Exp Med Biol"},{"key":"1707_CR38","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/s0002-9440(10)64964-4","volume":"156","author":"HJ Marti","year":"2000","unstructured":"Marti HJ, Bernaudin M, Bellail A et al (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156:965\u2013976. https:\/\/doi.org\/10.1016\/s0002-9440(10)64964-4","journal-title":"Am J Pathol"},{"key":"1707_CR39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/164_2021_494","volume":"273","author":"CJ McDonald","year":"2022","unstructured":"McDonald CJ, Blankenheim ZJ, Drewes LR (2022) Brain endothelial cells: metabolic flux and energy metabolism. Handb Exp Pharmacol 273:59\u201379. https:\/\/doi.org\/10.1007\/164_2021_494","journal-title":"Handb Exp Pharmacol"},{"key":"1707_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040812","author":"S Rehman","year":"2024","unstructured":"Rehman S, Nadeem A, Akram U et al (2024) Molecular mechanisms of ischemic stroke: a review integrating clinical imaging and therapeutic perspectives. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12040812","journal-title":"Biomedicines"},{"key":"1707_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00022","volume":"9","author":"MJ Rogatzki","year":"2015","unstructured":"Rogatzki MJ, Ferguson BS, Goodwin ML, Gladden LB (2015) Lactate is always the end product of glycolysis. Front Neurosci 9:22. https:\/\/doi.org\/10.3389\/fnins.2015.00022","journal-title":"Front Neurosci"},{"key":"1707_CR42","doi-asserted-by":"publisher","first-page":"7086","DOI":"10.1073\/pnas.95.12.7086","volume":"95","author":"JM Rosenstein","year":"1998","unstructured":"Rosenstein JM, Mani N, Silverman WF, Krum JM (1998) Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc Natl Acad Sci U S A 95:7086\u20137091. https:\/\/doi.org\/10.1073\/pnas.95.12.7086","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1707_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.hest.2020.09.001","volume":"1","author":"J Ruan","year":"2020","unstructured":"Ruan J, Yao Y (2020) Behavioral tests in rodent models of stroke. Brain Hemorrhages 1:171\u2013184. https:\/\/doi.org\/10.1016\/j.hest.2020.09.001","journal-title":"Brain Hemorrhages"},{"key":"1707_CR44","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1177\/0271678x17701460","volume":"37","author":"A Salehi","year":"2017","unstructured":"Salehi A, Zhang JH, Obenaus A (2017) Response of the cerebral vasculature following traumatic brain injury. J Cereb Blood Flow Metab 37:2320\u20132339. https:\/\/doi.org\/10.1177\/0271678x17701460","journal-title":"J Cereb Blood Flow Metab"},{"key":"1707_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4161\/cc.27519","volume":"13","author":"S Schoors","year":"2014","unstructured":"Schoors S, Cantelmo AR, Georgiadou M et al (2014) Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy? Cell Cycle 13:16\u201322. https:\/\/doi.org\/10.4161\/cc.27519","journal-title":"Cell Cycle"},{"key":"1707_CR46","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/1947601911423031","volume":"2","author":"M Shibuya","year":"2011","unstructured":"Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer 2:1097\u20131105. https:\/\/doi.org\/10.1177\/1947601911423031","journal-title":"Genes Cancer"},{"key":"1707_CR47","doi-asserted-by":"publisher","first-page":"1170675","DOI":"10.3389\/fneur.2023.1170675","volume":"14","author":"JD Sokolowski","year":"2023","unstructured":"Sokolowski JD, Soldozy S, Sharifi KA et al (2023) Preclinical models of middle cerebral artery occlusion: new imaging approaches to a classic technique. Front Neurol 14:1170675. https:\/\/doi.org\/10.3389\/fneur.2023.1170675","journal-title":"Front Neurol"},{"key":"1707_CR48","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000362276","volume":"51","author":"PC Stapor","year":"2014","unstructured":"Stapor PC, Sweat RS, Dashti DC, Betancourt AM, Murfee WL (2014) Pericyte dynamics during angiogenesis: new insights from new identities. J Vasc Res 51:163\u2013174. https:\/\/doi.org\/10.1159\/000362276","journal-title":"J Vasc Res"},{"key":"1707_CR49","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029223","author":"A Szymborska","year":"2018","unstructured":"Szymborska A, Gerhardt H (2018) Hold me, but not too tight-endothelial cell-cell junctions in angiogenesis. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a029223","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1707_CR50","doi-asserted-by":"publisher","first-page":"1395167","DOI":"10.3389\/fphar.2024.1395167","volume":"15","author":"L Tang","year":"2024","unstructured":"Tang L, Liu Z, Ji Z et al (2024) Promotion of mature angiogenesis in ischemic stroke by Taohong Siwu decoction through glycolysis activation. Front Pharmacol 15:1395167. https:\/\/doi.org\/10.3389\/fphar.2024.1395167","journal-title":"Front Pharmacol"},{"key":"1707_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012683","author":"PP Tregub","year":"2022","unstructured":"Tregub PP, Averchuk AS, Baranich TI, Ryazanova MV, Salmina AB (2022) Physiological and pathological remodeling of cerebral microvessels. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232012683","journal-title":"Int J Mol Sci"},{"key":"1707_CR52","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jneumeth.2004.04.029","volume":"139","author":"K T\u00fcreyen","year":"2004","unstructured":"T\u00fcreyen K, Vemuganti R, Sailor KA, Dempsey RJ (2004) Infarct volume quantification in mouse focal cerebral ischemia: a comparison of triphenyltetrazolium chloride and cresyl violet staining techniques. J Neurosci Methods 139:203\u2013207. https:\/\/doi.org\/10.1016\/j.jneumeth.2004.04.029","journal-title":"J Neurosci Methods"},{"key":"1707_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.670653","volume":"12","author":"K Ullah","year":"2021","unstructured":"Ullah K, Wu R (2021) Hypoxia-inducible factor regulates endothelial metabolism in cardiovascular disease. Front Physiol 12:670653. https:\/\/doi.org\/10.3389\/fphys.2021.670653","journal-title":"Front Physiol"},{"key":"1707_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0305-9","volume":"14","author":"L Wang","year":"2019","unstructured":"Wang L, Pavlou S, Du X, Bhuckory M, Xu H, Chen M (2019) Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Mol Neurodegener 14:2. https:\/\/doi.org\/10.1186\/s13024-019-0305-9","journal-title":"Mol Neurodegener"},{"key":"1707_CR55","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13020-023-00731-x","volume":"18","author":"C Wei","year":"2023","unstructured":"Wei C, Wang J, Yu J et al (2023a) Therapy of traumatic brain injury by modern agents and traditional Chinese medicine. Chin Med 18:25. https:\/\/doi.org\/10.1186\/s13020-023-00731-x","journal-title":"Chin Med"},{"key":"1707_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155104","volume":"121","author":"J Wei","year":"2023","unstructured":"Wei J, Xie J, He J et al (2023b) Active fraction of Polyrhachis vicina (Roger) alleviated cerebral ischemia\/reperfusion injury by targeting SIRT3-mediated mitophagy and angiogenesis. Phytomedicine 121:155104. https:\/\/doi.org\/10.1016\/j.phymed.2023.155104","journal-title":"Phytomedicine"},{"key":"1707_CR57","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.15252\/embj.201696150","volume":"36","author":"BW Wong","year":"2017","unstructured":"Wong BW, Marsch E, Treps L, Baes M, Carmeliet P (2017) Endothelial cell metabolism in health and disease: impact of hypoxia. EMBO J 36:2187\u20132203. https:\/\/doi.org\/10.15252\/embj.201696150","journal-title":"EMBO J"},{"key":"1707_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.572624","volume":"11","author":"SP Wu","year":"2020","unstructured":"Wu SP, Wang N, Zhao L (2020) Network pharmacology reveals the mechanism of activity of Tongqiao Huoxue decoction extract against middle cerebral artery occlusion-induced cerebral ischemia-reperfusion injury. Front Pharmacol 11:572624. https:\/\/doi.org\/10.3389\/fphar.2020.572624","journal-title":"Front Pharmacol"},{"key":"1707_CR59","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13041-025-01182-1","volume":"18","author":"L Xue","year":"2025","unstructured":"Xue L, Ouyang W, Qi P et al (2025) Key mechanisms of angiogenesis in the infarct core: association of macrophage infiltration with venogenesis. Mol Brain 18:12. https:\/\/doi.org\/10.1186\/s13041-025-01182-1","journal-title":"Mol Brain"},{"key":"1707_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062386","author":"Z Yao","year":"2025","unstructured":"Yao Z, Li J, Yu J et al (2025) Glycometabolic regulation of angiogenesis: mechanisms and therapeutic strategies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26062386","journal-title":"Int J Mol Sci"},{"key":"1707_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48676-2","volume":"9","author":"B Yetkin-Arik","year":"2019","unstructured":"Yetkin-Arik B, Vogels IMC, Nowak-Sliwinska P et al (2019b) The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis. Sci Rep 9:12608. https:\/\/doi.org\/10.1038\/s41598-019-48676-2","journal-title":"Sci Rep"},{"key":"1707_CR62","doi-asserted-by":"crossref","unstructured":"Yetkin-Arik B, Vogels IMC, Nowak-Sliwinska P, et al (2019a) The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis. In Editor ed.^eds. Book The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis, p 12608","DOI":"10.1038\/s41598-019-48676-2"},{"key":"1707_CR63","doi-asserted-by":"publisher","first-page":"644","DOI":"10.5935\/1678-9741.20150081","volume":"30","author":"SM Yuan","year":"2015","unstructured":"Yuan SM (2015) \u0391-smooth muscle actin and ACTA2 gene expressions in vasculopathies. Braz J Cardiovasc Surg 30:644\u2013649. https:\/\/doi.org\/10.5935\/1678-9741.20150081","journal-title":"Braz J Cardiovasc Surg"},{"key":"1707_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111460","volume":"138","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Zhang L, Liu Y et al (2021) Research progress on the pharmacological effect and clinical application of Tongqiao Huoxue Decoction in the treatment of ischaemic stroke. Biomed Pharmacother 138:111460. https:\/\/doi.org\/10.1016\/j.biopha.2021.111460","journal-title":"Biomed Pharmacother"},{"key":"1707_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114693","volume":"283","author":"X Zhou","year":"2022","unstructured":"Zhou X, Shao T, Xie X et al (2022) Tongqiao huoxue decoction for the treatment of acute ischemic stroke: a systematic review and meta-analysis. J Ethnopharmacol 283:114693. https:\/\/doi.org\/10.1016\/j.jep.2021.114693","journal-title":"J Ethnopharmacol"},{"key":"1707_CR66","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/atvbaha.114.303194","volume":"34","author":"H Zhu","year":"2014","unstructured":"Zhu H, Sun A, Zou Y, Ge J (2014) Inducible metabolic adaptation promotes mesenchymal stem cell therapy for ischemia: a hypoxia-induced and glycogen-based energy prestorage strategy. Arterioscler Thromb Vasc Biol 34:870\u2013876. https:\/\/doi.org\/10.1161\/atvbaha.114.303194","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1707_CR67","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040273","author":"B Zhu","year":"2024","unstructured":"Zhu B, Cheng L, Huang B, Liu R, Ren B (2024) Central role of hypoxia-inducible factor-1\u03b1 in metabolic reprogramming of cancer cells: a review. Medicine. https:\/\/doi.org\/10.1097\/MD.0000000000040273","journal-title":"Medicine"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01707-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-025-01707-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01707-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:59:41Z","timestamp":1761303581000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-025-01707-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":67,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["1707"],"URL":"https:\/\/doi.org\/10.1007\/s11011-025-01707-6","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures involving animals were conducted in accordance with the guidelines of the Animal Ethics Committee of Heilongjiang University of Chinese Medicine and approved under Ethical Approval No: 2023101602. The laboratory animals were obtained from a licensed supplier (Laboratory Animal Certificate No: SCXK2008-0001). All efforts were made to minimize animal suffering and reduce the number of animals used.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"288"}}