{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:59:06Z","timestamp":1792425546115,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-025-01724-5","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:35:02Z","timestamp":1760430902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2\/STAT3 signaling pathway"],"prefix":"10.1007","volume":"40","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuqiang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3612-8895","authenticated-orcid":false,"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"1724_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040706","author":"AY Baev","year":"2022","unstructured":"Baev AY, Vinokurov AY, Novikova IN, Dremin VV, Potapova EV, Abramov AY (2022) Interaction of mitochondrial calcium and ROS in neurodegeneration. Cells. https:\/\/doi.org\/10.3390\/cells11040706","journal-title":"Cells"},{"issue":"4","key":"1724_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153418","volume":"11","author":"HS Basrai","year":"2016","unstructured":"Basrai HS, Christie KJ, Turbic A, Bye N, Turnley AM (2016) Suppressor of cytokine signaling-2 (SOCS2) regulates the microglial response and improves functional outcome after traumatic brain injury in mice. PLoS ONE 11(4):e0153418. https:\/\/doi.org\/10.1371\/journal.pone.0153418","journal-title":"PLoS ONE"},{"key":"1724_CR3","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.expneurol.2019.03.014","volume":"317","author":"S Bhowmick","year":"2019","unstructured":"Bhowmick S, D\u2019Mello V, Caruso D, Wallerstein A, Muneer PMA (2019) Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury. Exp Neurol 317:260\u2013270. https:\/\/doi.org\/10.1016\/j.expneurol.2019.03.014","journal-title":"Exp Neurol"},{"key":"1724_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2023.102273","volume":"131","author":"Z Cai","year":"2023","unstructured":"Cai Z, Zhang Z, Zhang L, Tan R, Wang Y, Sun M, Hu X, Ge Q, An J, Lu H (2023) The kinase inhibitory region of SOCS3 attenuates reactive astrogliosis and astroglial scar in mice after traumatic brain injury. J Chem Neuroanat 131:102273. https:\/\/doi.org\/10.1016\/j.jchemneu.2023.102273","journal-title":"J Chem Neuroanat"},{"issue":"2","key":"1724_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mcna.2019.11.001","volume":"104","author":"A Capizzi","year":"2020","unstructured":"Capizzi A, Woo J, Verduzco-Gutierrez M (2020) Traumatic brain injury: an overview of Epidemiology, Pathophysiology, and medical management. Med Clin North Am 104(2):213\u2013238. https:\/\/doi.org\/10.1016\/j.mcna.2019.11.001","journal-title":"Med Clin North Am"},{"key":"1724_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176557","volume":"972","author":"HQ Chen","year":"2024","unstructured":"Chen HQ, Zhang QG, Zhang XY, Zeng XB, Xu JW, Ling S (2024) 4\u2019-O-methylbavachalcone alleviates ischemic stroke injury by inhibiting parthanatos and promoting SIRT3. Eur J Pharmacol 972:176557. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176557","journal-title":"Eur J Pharmacol"},{"key":"1724_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbrc.2021.04.089","volume":"559","author":"K Cho","year":"2021","unstructured":"Cho K, Kim S, Choi SH (2021) Suppressor of cytokine signaling 2 is induced in Huntington\u2019s disease and involved in autophagy. Biochem Biophys Res Commun 559:21\u201327. https:\/\/doi.org\/10.1016\/j.bbrc.2021.04.089","journal-title":"Biochem Biophys Res Commun"},{"key":"1724_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1872593","volume":"2019","author":"A Cramer","year":"2019","unstructured":"Cramer A, de Lima Oliveira BC, Leite PG, Rodrigues DH, Brant F, Esper L, Pimentel PMO, Rezende RM, Rachid MA, Teixeira AL, Faria AMC, Teixeira MM, Machado FS (2019) Role of SOCS2 in the regulation of immune response and development of the experimental autoimmune encephalomyelitis. Mediators Inflamm 2019:1872593. https:\/\/doi.org\/10.1155\/2019\/1872593","journal-title":"Mediators Inflamm"},{"key":"1724_CR9","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.brainresbull.2016.09.011","volume":"127","author":"LF da Cunha Sousa","year":"2016","unstructured":"da Cunha Sousa LF, Rachid MA, Lima GK, de Miranda AS, de Carvalho Vilela M, Lacerda Queiroz N, Rodrigues DH, Campos MA, Kroon EG, Machado FS, Teixeira AL (2016) Suppressor of cytokine signaling 2 (SOCS2) contributes to encephalitis in a model of herpes infection in mice. Brain Res Bull 127:164\u2013170. https:\/\/doi.org\/10.1016\/j.brainresbull.2016.09.011","journal-title":"Brain Res Bull"},{"issue":"1","key":"1724_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s1734-1140(09)70014-3","volume":"61","author":"F Di Lisa","year":"2009","unstructured":"Di Lisa F, Kaludercic N, Carpi A, Menab\u00f2 R, Giorgio M (2009) Mitochondria and vascular pathology. Pharmacol Rep 61(1):123\u2013130. https:\/\/doi.org\/10.1016\/s1734-1140(09)70014-3","journal-title":"Pharmacol Rep"},{"issue":"11","key":"1724_CR11","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/circresaha.123.323596","volume":"134","author":"A Dikalova","year":"2024","unstructured":"Dikalova A, Fehrenbach D, Mayorov V, Panov A, Ao M, Lantier L, Amarnath V, Lopez MG, Billings FTt, Sack MN, Dikalov S (2024) Mitochondrial CypD acetylation promotes endothelial dysfunction and hypertension. Circ Res 134(11):1451\u20131464. https:\/\/doi.org\/10.1161\/circresaha.123.323596","journal-title":"Circ Res"},{"issue":"5","key":"1724_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.biopsych.2021.07.008","volume":"91","author":"JR Fann","year":"2022","unstructured":"Fann JR, Quinn DK, Hart T (2022) Treatment of psychiatric problems after traumatic brain injury. Biol Psychiatry 91(5):508\u2013521. https:\/\/doi.org\/10.1016\/j.biopsych.2021.07.008","journal-title":"Biol Psychiatry"},{"key":"1724_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176765","volume":"978","author":"Y Han","year":"2024","unstructured":"Han Y, Wang C, Li X, Liang G (2024) PARP-1 dependent cell death pathway (Parthanatos) mediates early brain injury after subarachnoid hemorrhage. Eur J Pharmacol 978:176765. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176765","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1724_CR14","doi-asserted-by":"publisher","first-page":"163","DOI":"10.18388\/abp.2020_6383","volume":"70","author":"M He","year":"2023","unstructured":"He M, Cai Y, Yuan Z, Zhang L, Lu H (2023) Upregulation of SOCS2 causes mitochondrial dysfunction and promotes ferroptosis in pancreatic cancer cells. Acta Biochim Pol 70(1):163\u2013168. https:\/\/doi.org\/10.18388\/abp.2020_6383","journal-title":"Acta Biochim Pol"},{"key":"1724_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137292","author":"P Huang","year":"2022","unstructured":"Huang P, Chen G, Jin W, Mao K, Wan H, He Y (2022) Molecular mechanisms of parthanatos and its role in diverse diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23137292","journal-title":"Int J Mol Sci"},{"key":"1724_CR16","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141110","author":"J Jin","year":"2023","unstructured":"Jin J, Wang F, Tian J, Zhao X, Dong J, Wang N, Liu Z, Zhao H, Li W, Mang G, Hu S (2023) Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.141110","journal-title":"JCI Insight"},{"issue":"2","key":"1724_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3109\/08977194.2012.660936","volume":"30","author":"H Kiu","year":"2012","unstructured":"Kiu H, Nicholson SE (2012) Biology and significance of the JAK\/STAT signalling pathways. Growth Factors 30(2):88\u2013106. https:\/\/doi.org\/10.3109\/08977194.2012.660936","journal-title":"Growth Factors"},{"issue":"6","key":"1724_CR18","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","volume":"27","author":"EG Knox","year":"2022","unstructured":"Knox EG, Aburto MR, Clarke G, Cryan JF, O\u2019Driscoll CM (2022) The blood-brain barrier in aging and neurodegeneration. Mol Psychiatry 27(6):2659\u20132673. https:\/\/doi.org\/10.1038\/s41380-022-01511-z","journal-title":"Mol Psychiatry"},{"key":"1724_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106791","volume":"192","author":"L Li","year":"2023","unstructured":"Li L, Li F, Bai X, Jia H, Wang C, Li P, Zhang Q, Guan S, Peng R, Zhang S, Dong JF, Zhang J, Xu X (2023) Circulating extracellular vesicles from patients with traumatic brain injury induce cerebrovascular endothelial dysfunction. Pharmacol Res 192:106791. https:\/\/doi.org\/10.1016\/j.phrs.2023.106791","journal-title":"Pharmacol Res"},{"issue":"5","key":"1724_CR20","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/febs.16361","volume":"290","author":"H Martini","year":"2023","unstructured":"Martini H, Passos JF (2023) Cellular senescence: all roads lead to mitochondria. FEBS J 290(5):1186\u20131202. https:\/\/doi.org\/10.1111\/febs.16361","journal-title":"FEBS J"},{"issue":"1","key":"1724_CR21","first-page":"304","volume":"2","author":"AJ McGovern","year":"2021","unstructured":"McGovern AJ, Barreto GE (2021) Mitochondria dysfunction and inflammation in traumatic brain injury: androgens to the battlefront. Androgens: Clinical Research and Therapeutics 2(1):304\u2013315","journal-title":"Androgens: Clinical Research and Therapeutics"},{"issue":"3","key":"1724_CR22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.neuroscience.2004.12.041","volume":"132","author":"MI Ransome","year":"2005","unstructured":"Ransome MI, Turnley AM (2005) Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2. Neuroscience 132(3):673\u2013687. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.12.041","journal-title":"Neuroscience"},{"key":"1724_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab018","author":"AM Sackheim","year":"2021","unstructured":"Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D\u2019Alessandro A, Nemkov T, Nelson MT, Freeman K (2021) Traumatic brain injury impairs systemic vascular function through disruption of inward-rectifier potassium channels. Function. https:\/\/doi.org\/10.1093\/function\/zqab018","journal-title":"Function"},{"issue":"3","key":"1724_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.neuron.2019.06.002","volume":"103","author":"DK Sandsmark","year":"2019","unstructured":"Sandsmark DK, Bashir A, Wellington CL, Diaz-Arrastia R (2019) Cerebral microvascular injury: a potentially treatable endophenotype of traumatic brain injury-induced neurodegeneration. Neuron 103(3):367\u2013379. https:\/\/doi.org\/10.1016\/j.neuron.2019.06.002","journal-title":"Neuron"},{"issue":"7","key":"1724_CR25","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1007\/s10571-023-01372-2","volume":"43","author":"R Schmitt","year":"2023","unstructured":"Schmitt R, Qayum S, Pliss A, Kuzmin AN, Muthaiah VPK, Kaliyappan K, Prasad PN, Mahajan SD (2023) Mitochondrial dysfunction and apoptosis in brain microvascular endothelial cells following blast traumatic brain injury. Cell Mol Neurobiol 43(7):3639\u20133651. https:\/\/doi.org\/10.1007\/s10571-023-01372-2","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"1724_CR26","doi-asserted-by":"publisher","first-page":"jrm00181","DOI":"10.2340\/1650-1977-2823","volume":"53","author":"HL S\u00f8berg","year":"2021","unstructured":"S\u00f8berg HL, Andelic N, Langhammer B, Tamber AL, Bruusgaard KA, Kleffelgaard I (2021) Effect of vestibular rehabilitation on change in health-related quality of life in patients with Dizziness and balance problems after traumatic brain injury: A randomized controlled trial. J Rehabil Med 53(4):jrm00181. https:\/\/doi.org\/10.2340\/1650-1977-2823","journal-title":"J Rehabil Med"},{"key":"1724_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106331","volume":"188","author":"SE Svirsky","year":"2023","unstructured":"Svirsky SE, Li Y, Henchir J, Rodina A, Carlson SW, Chiosis G, Dixon CE (2023) Experimental traumatic brain injury increases epichaperome formation. Neurobiol Dis 188:106331. https:\/\/doi.org\/10.1016\/j.nbd.2023.106331","journal-title":"Neurobiol Dis"},{"key":"1724_CR28","doi-asserted-by":"publisher","DOI":"10.1172\/jci164199","author":"J Tang","year":"2023","unstructured":"Tang J, Kang Y, Zhou Y, Shang N, Li X, Wang H, Lan J, Wang S, Wu L, Peng Y (2023) TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. J Clin Invest. https:\/\/doi.org\/10.1172\/jci164199","journal-title":"J Clin Invest"},{"key":"1724_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106269","volume":"186","author":"G van Hameren","year":"2023","unstructured":"van Hameren G, Muradov J, Minarik A, Aboghazleh R, Orr S, Cort S, Andrews K, McKenna C, Pham NT, MacLean MA, Friedman A (2023) Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury. Neurobiol Dis 186:106269. https:\/\/doi.org\/10.1016\/j.nbd.2023.106269","journal-title":"Neurobiol Dis"},{"key":"1724_CR30","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuroscience.2020.09.049","volume":"449","author":"X Wang","year":"2020","unstructured":"Wang X, Ge P (2020) Parthanatos in the pathogenesis of nervous system diseases. Neuroscience 449:241\u2013250. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.09.049","journal-title":"Neuroscience"},{"issue":"7\u20138","key":"1724_CR31","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s12031-023-02144-9","volume":"73","author":"D Wang","year":"2023","unstructured":"Wang D, Wang S, Zhu Q, Shen Z, Yang G, Chen Y, Luo C, Du Y, Hu Y, Wang W, Yang J (2023a) Prospects for nerve regeneration and gene therapy in the treatment of traumatic brain injury. J Mol Neurosci 73(7\u20138):578\u2013586. https:\/\/doi.org\/10.1007\/s12031-023-02144-9","journal-title":"J Mol Neurosci"},{"issue":"37","key":"1724_CR32","doi-asserted-by":"publisher","first-page":"33392","DOI":"10.1021\/acsomega.3c03084","volume":"8","author":"L Wang","year":"2023","unstructured":"Wang L, Ye B, Liu Y, Li J, Li C, Wen M, Li H (2023b) Xuebijing injection attenuates heat stroke-induced brain injury through oxidative stress blockage and parthanatos modulation via PARP-1\/AIF signaling. ACS Omega 8(37):33392\u201333402. https:\/\/doi.org\/10.1021\/acsomega.3c03084","journal-title":"ACS Omega"},{"issue":"1","key":"1724_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09843-y","volume":"40","author":"J Wang","year":"2024","unstructured":"Wang J, Jia Q, Jiang S, Lu W, Ning H (2024) POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2\/SLC7A11 signaling in gastric cancer. Cell Biol Toxicol 40(1):3. https:\/\/doi.org\/10.1007\/s10565-024-09843-y","journal-title":"Cell Biol Toxicol"},{"issue":"5","key":"1724_CR34","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1227\/NEU.0b013e31820c06b9","volume":"68","author":"H Wu","year":"2011","unstructured":"Wu H, Jiang H, Lu D, Qu C, Xiong Y, Zhou D, Chopp M, Mahmood A (2011) Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury. Neurosurgery 68(5):1363\u20131371. https:\/\/doi.org\/10.1227\/NEU.0b013e31820c06b9","journal-title":"Neurosurgery"},{"issue":"9","key":"1724_CR35","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1177\/0271678x20984976","volume":"41","author":"L Wu","year":"2021","unstructured":"Wu L, Islam MR, Lee J, Takase H, Guo S, Andrews AM, Buzhdygan TP, Mathew J, Li W, Arai K, Lo EH, Ramirez SH, Lok J (2021) ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: implications for vascular remodeling and blood brain barrier modulation. J Cereb Blood Flow Metab 41(9):2242\u20132255. https:\/\/doi.org\/10.1177\/0271678x20984976","journal-title":"J Cereb Blood Flow Metab"},{"key":"1724_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.855351","volume":"13","author":"X Xiang","year":"2022","unstructured":"Xiang X, Ma HZ, Chen YQ, Zhang DZ, Ma SX, Wang HJ, Liu DM, Yuan Y, Cai H (2022) GM-CSF-mirna-Jak2\/Stat3 signaling mediates chemotherapy-induced cancer cell stemness in gastric cancer. Front Pharmacol 13:855351. https:\/\/doi.org\/10.3389\/fphar.2022.855351","journal-title":"Front Pharmacol"},{"issue":"22","key":"1724_CR37","doi-asserted-by":"publisher","first-page":"12980","DOI":"10.1111\/jcmm.15894","volume":"24","author":"G Xiaoying","year":"2020","unstructured":"Xiaoying G, Guo M, Jie L, Yanmei Z, Ying C, Shengjie S, Haiyan G, Feixiang S, Sihua Q, Jiahang S (2020) Circhivep2 contributes to microglia activation and inflammation via miR-181a-5p\/SOCS2 signalling in mice with Kainic acid-induced epileptic seizures. J Cell Mol Med 24(22):12980\u201312993. https:\/\/doi.org\/10.1111\/jcmm.15894","journal-title":"J Cell Mol Med"},{"issue":"1","key":"1724_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111547","volume":"384","author":"H Xu","year":"2019","unstructured":"Xu H, Li X, Wu X, Yang Y, Dai S, Lei T, Jing D, Luo P, Luo E (2019) Iduna protects HT22 cells by inhibiting parthanatos: the role of the p53-MDM2 pathway. Exp Cell Res 384(1):111547. https:\/\/doi.org\/10.1016\/j.yexcr.2019.111547","journal-title":"Exp Cell Res"},{"key":"1724_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119170","volume":"340","author":"Y Xu","year":"2025","unstructured":"Xu Y, Sha W, Lu J, Yu S, Jin X, Chen C, Ge G, Lei T (2025) Danggui liuhuang decoction ameliorates endothelial dysfunction by inhibiting the JAK2\/STAT3 mediated inflammation. J Ethnopharmacol 340:119170. https:\/\/doi.org\/10.1016\/j.jep.2024.119170","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"1724_CR40","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/nri2093","volume":"7","author":"A Yoshimura","year":"2007","unstructured":"Yoshimura A, Naka T, Kubo M (2007) SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7(6):454\u2013465. https:\/\/doi.org\/10.1038\/nri2093","journal-title":"Nat Rev Immunol"},{"key":"1724_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cytogfr.2024.03.003","volume":"77","author":"L Zeng","year":"2024","unstructured":"Zeng L, Hu P, Zhang Y, Li M, Zhao Y, Li S, Luo A (2024) Macrophage migration inhibitor factor (MIF): potential role in cognitive impairment disorders. Cytokine Growth Factor Rev 77:67\u201375. https:\/\/doi.org\/10.1016\/j.cytogfr.2024.03.003","journal-title":"Cytokine Growth Factor Rev"},{"key":"1724_CR42","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.wneu.2019.11.172","volume":"138","author":"B Zhang","year":"2020","unstructured":"Zhang B, Gao Y, Li Q, Sun D, Dong X, Li X, Xin W, Zhang J (2020) Effects of brain-derived mitochondria on the function of neuron and vascular endothelial cell after traumatic brain injury. World Neurosurg 138:e1\u2013e9. https:\/\/doi.org\/10.1016\/j.wneu.2019.11.172","journal-title":"World Neurosurg"},{"issue":"1","key":"1724_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114103","volume":"440","author":"L Zhang","year":"2024","unstructured":"Zhang L, Xiang Y, Cao C, Tan J, Li F, Yang X (2024) Ciliary neurotrophic factor promotes the development of homocysteine-induced vascular endothelial injury through inflammation mediated by the JAK2\/STAT3 signaling pathway. Exp Cell Res 440(1):114103. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114103","journal-title":"Exp Cell Res"},{"issue":"2","key":"1724_CR44","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cyto.2011.07.018","volume":"56","author":"J Zhao","year":"2011","unstructured":"Zhao J, Li G, Zhang Y, Su X, Hang C (2011) The potential role of JAK2\/STAT3 pathway on the anti-apoptotic effect of Recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine 56(2):343\u2013350. https:\/\/doi.org\/10.1016\/j.cyto.2011.07.018","journal-title":"Cytokine"},{"issue":"5","key":"1724_CR45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.5847\/wjem.j.1920-8642.2022.089","volume":"13","author":"XH Zhou","year":"2022","unstructured":"Zhou XH, Xu H, Xu C, Yan YC, Zhang LS, Sun Q, Wang WL, Shi YJ (2022) Hepatocellular carcinoma-derived exosomal miRNA-761 regulates the tumor microenvironment by targeting the SOCS2\/JAK2\/STAT3 pathway. World J Emerg Med 13(5):379\u2013385. https:\/\/doi.org\/10.5847\/wjem.j.1920-8642.2022.089","journal-title":"World J Emerg Med"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01724-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-025-01724-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-025-01724-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:59:37Z","timestamp":1761303577000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-025-01724-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["1724"],"URL":"https:\/\/doi.org\/10.1007\/s11011-025-01724-5","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental protocols were approved by the Ethics Review Committee of Animal Experiments. All methods were performed in accordance with the relevant guidelines and regulations and in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\u00a0<!--Emphasis Type='Bold' removed-->and consent for publication."}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"289"}}