{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:52:50Z","timestamp":1775555570413,"version":"3.50.1"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01809-9","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:29:17Z","timestamp":1775546957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of 2-Oxoglutarate dehydrogenase complex mitochondrial enzyme in alzheimer\u2019s disease: a literature review and bioinformatics workflow"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-2786","authenticated-orcid":false,"given":"Fatemeh","family":"Sayehmiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2845-2078","authenticated-orcid":false,"given":"Mohanna","family":"Parvenous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7296-3218","authenticated-orcid":false,"given":"Kimia","family":"Vakili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0991-7752","authenticated-orcid":false,"given":"Rasoul","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-9306","authenticated-orcid":false,"given":"Zehra","family":"Batool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-9448","authenticated-orcid":false,"given":"Narges","family":"Bazgir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-7118","authenticated-orcid":false,"given":"Kiarash","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-4017","authenticated-orcid":false,"given":"Maral","family":"Moafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-7340","authenticated-orcid":false,"given":"Mohammad Javad","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0023-810X","authenticated-orcid":false,"given":"Mohammadreza","family":"Hajiesmaeili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"1809_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00252","author":"I Agrawal","year":"2020","unstructured":"Agrawal I, Jha S (2020) Mitochondrial dysfunction and Alzheimer\u2019s disease: role of microglia. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2020.00252","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"1809_CR2","doi-asserted-by":"publisher","first-page":"624","DOI":"10.2174\/1871527315666160321110607","volume":"15","author":"B Ali","year":"2016","unstructured":"Ali B, Jamal QM, Shams S, Al-Wabel NA, Siddiqui MU, Alzohairy MA, Al Karaawi MA, Kesari KK, Mushtaq G, Kamal MA (2016) In silico analysis of green tea polyphenols as inhibitors of ache and BChE enzymes in Alzheimer\u2019s disease treatment. CNS Neurol Disord Drug Targets 15(5):624\u2013628","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"1809_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070862","author":"J Ali","year":"2024","unstructured":"Ali J, Choe K, Park JS, Park HY, Kang H, Park TJ, Kim MO (2024) The interplay of protein aggregation, genetics, and oxidative stress in Alzheimer\u2019s disease: role for natural antioxidants and immunotherapeutics. Antioxidants. https:\/\/doi.org\/10.3390\/antiox13070862","journal-title":"Antioxidants"},{"issue":"Suppl 1","key":"1809_CR4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1471-4159.2009.05942.x","volume":"109","author":"A Ambrus","year":"2009","unstructured":"Ambrus A, Tretter L, Adam-Vizi V (2009) Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid. J Neurochem 109(Suppl 1):222\u2013229","journal-title":"J Neurochem"},{"key":"1809_CR5","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.freeradbiomed.2015.10.001","volume":"89","author":"A Ambrus","year":"2015","unstructured":"Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V (2015) Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components. Free Radic Biol Med 89:642\u2013650","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1809_CR6","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1021\/bi7017464","volume":"47","author":"MA Applegate","year":"2008","unstructured":"Applegate MA, Humphries KM, Szweda LI (2008) Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry 47(1):473\u2013478","journal-title":"Biochemistry"},{"issue":"9","key":"1809_CR7","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1007\/s12035-016-0182-y","volume":"54","author":"R Arora","year":"2017","unstructured":"Arora R, Deshmukh R (2017) Embelin attenuates intracerebroventricular streptozotocin-induced behavioral, biochemical, and neurochemical abnormalities in rats. Mol Neurobiol 54(9):6670\u20136680","journal-title":"Mol Neurobiol"},{"issue":"5","key":"1809_CR8","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.3390\/cimb45050283","volume":"45","author":"A Atlante","year":"2023","unstructured":"Atlante A, Valenti D (2023) Mitochondria have made a long evolutionary path from ancient bacteria immigrants within eukaryotic cells to essential cellular hosts and key players in human health and disease. Curr Issues Mol Biol 45(5):4451\u20134479","journal-title":"Curr Issues Mol Biol"},{"key":"1809_CR9","unstructured":"Blass J (1993) Pathophysiology of the Alzheimer\u2019s syndrome. Neurology 43(8)"},{"issue":"5","key":"1809_CR10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000017165","volume":"10","author":"JP Blass","year":"1999","unstructured":"Blass JP, Gibson GE (1999) Cerebrometabolic aspects of delirium in relationship to dementia. Dement Geriatr Cogn Disord 10(5):335\u2013338","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"1","key":"1809_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1749-6632.2000.tb06370.x","volume":"903","author":"JP Blass","year":"2000","unstructured":"Blass JP, Sheu RKF, Gibson GE (2000) Inherent abnormalities in energy metabolism in alzheimer disease: interaction with cerebrovascular compromise. Ann N Y Acad Sci 903(1):204\u2013221","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"1809_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1042\/BJ20140772","volume":"463","author":"DA Butterfield","year":"2014","unstructured":"Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M (2014) Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down\u2019s syndrome and Alzheimer\u2019s disease brain. Biochem J 463(2):177\u2013189","journal-title":"Biochem J"},{"issue":"10","key":"1809_CR13","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1007\/BF00964982","volume":"10","author":"RF Butterworth","year":"1985","unstructured":"Butterworth RF, Giguere JF, Besnard AM (1985) Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. Neurochem Res 10(10):1417\u20131428","journal-title":"Neurochem Res"},{"issue":"4","key":"1809_CR14","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/BF00965326","volume":"11","author":"RF Butterworth","year":"1986","unstructured":"Butterworth RF, Gigu\u00e8re JF, Besnard AM (1986) Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. Alpha-ketoglutarate dehydrogenase. Neurochem Res 11(4):567\u2013577","journal-title":"Neurochem Res"},{"issue":"5","key":"1809_CR15","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/j.1530-0277.1993.tb05668.x","volume":"17","author":"RF Butterworth","year":"1993","unstructured":"Butterworth RF, Kril JJ, Harper CG (1993) Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke\u2010Korsakoff syndrome. Alcohol Clin Exp Res 17(5):1084\u20131088","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"1809_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/jnen\/59.3.207","volume":"59","author":"NY Calingasan","year":"2000","unstructured":"Calingasan NY, Huang PL, Chun HS, Fabian A, Gibson GE (2000) Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J Neuropathol Exp Neurol 59(3):207\u2013217","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"1809_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1046\/j.0022-3042.2001.00681.x","volume":"80","author":"CS Casley","year":"2002","unstructured":"Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA (2002) \u03b2-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80(1):91\u2013100","journal-title":"J Neurochem"},{"issue":"24","key":"1809_CR18","doi-asserted-by":"publisher","first-page":"18195","DOI":"10.1074\/jbc.M000040200","volume":"275","author":"SL Chan","year":"2000","unstructured":"Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP (2000) Presenilin-1 mutations increase levels of Ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275(24):18195\u201318200","journal-title":"J Biol Chem"},{"issue":"26","key":"1809_CR19","doi-asserted-by":"publisher","first-page":"7035","DOI":"10.1523\/JNEUROSCI.1012-06.2006","volume":"26","author":"DT Chang","year":"2006","unstructured":"Chang DT, Honick AS, Reynolds IJ (2006) Mitochondrial trafficking to synapses in cultured primary cortical neurons. J Neurosci 26(26):7035\u20137045","journal-title":"J Neurosci"},{"issue":"7","key":"1809_CR20","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1038\/s41380-022-01538-2","volume":"27","author":"C Conze","year":"2022","unstructured":"Conze C, Rierola M, Trushina NI, Peters M, Janning D, Holzer M, Heinisch JJ, Arendt T, Bakota L, Brandt R (2022) Caspase-cleaved Tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Mol Psychiatry 27(7):3010\u20133023","journal-title":"Mol Psychiatry"},{"key":"1809_CR21","doi-asserted-by":"publisher","first-page":"1264448","DOI":"10.3389\/fnagi.2023.1264448","volume":"15","author":"L Dan","year":"2023","unstructured":"Dan L, Zhang Z (2023) Alzheimer\u2019s disease: an axonal injury disease? Front Aging Neurosci 15:1264448","journal-title":"Front Aging Neurosci"},{"issue":"25","key":"1809_CR22","doi-asserted-by":"publisher","first-page":"23802","DOI":"10.1074\/jbc.M500356200","volume":"280","author":"DC David","year":"2005","unstructured":"David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dr\u00f6se S, Brandt U, M\u00fcller WE (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L Tau Transgenic mice. J Biol Chem 280(25):23802\u201323814","journal-title":"J Biol Chem"},{"issue":"4","key":"1809_CR23","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/01.STR.0000014421.15948.67","volume":"33","author":"J De la Torre","year":"2002","unstructured":"De la Torre J (2002) Alzheimer disease as a vascular disorder: nosological evidence. Stroke 33(4):1152\u20131162","journal-title":"Stroke"},{"issue":"3","key":"1809_CR24","first-page":"568","volume":"4","author":"MJ de Leon","year":"1983","unstructured":"de Leon MJ, Ferris SH, George AE, Christman DR, Fowler JS, Gentes C, Reisberg B, Gee B, Emmerich M, Yonekura Y (1983) Positron emission tomographic studies of aging and alzheimer disease. Am J Neuroradiol 4(3):568\u2013571","journal-title":"Am J Neuroradiol"},{"key":"1809_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020279","author":"D Dias","year":"2025","unstructured":"Dias D, Socodato R (2025) Beyond amyloid and tau: the critical role of microglia in Alzheimer\u2019s disease therapeutics. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines13020279","journal-title":"Biomedicines"},{"issue":"4","key":"1809_CR26","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.neuron.2012.06.026","volume":"75","author":"B DuBoff","year":"2012","unstructured":"DuBoff B, G\u00f6tz J, Feany MB (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75(4):618\u2013632","journal-title":"Neuron"},{"issue":"11","key":"1809_CR27","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1096\/fj.11-186650","volume":"25","author":"M Dumont","year":"2011","unstructured":"Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, Yang L, Starkov AA, Beal F (2011) Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede Tau pathology in P301S Transgenic mice. FASEB J 25(11):4063\u20134072","journal-title":"FASEB J"},{"issue":"2","key":"1809_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/alzrt74","volume":"3","author":"A Eckert","year":"2011","unstructured":"Eckert A, Schmitt K, G\u00f6tz J (2011) Mitochondrial dysfunction-the beginning of the end in alzheimer\u2019s disease? Separate and synergistic modes of Tau and amyloid-\u03b2 toxicity. Alzheimers Res Ther 3(2):1\u201311","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"1809_CR29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0248-8663(05)81453-5","volume":"15","author":"J Eisinger","year":"1994","unstructured":"Eisinger J, Arroyo P, Braquet M, Arroyo H, Ayavou T (1994) Transc\u00e9tolases \u00e9rythrocytaires et maladie d\u2019Alzheimer. La Revue de M\u00e9decine Interne 15(6):387\u2013389","journal-title":"La Revue de M\u00e9decine Interne"},{"issue":"2","key":"1809_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0197-4580(80)90005-6","volume":"1","author":"SH Ferris","year":"1980","unstructured":"Ferris SH, de Leon MJ, Wolf AP, Farkas T, Christman DR, Reisberg B, Fowler JS, MacGregor R, Goldman A, George AE (1980) Positron emission tomography in the study of aging and senile dementia. Neurobiol Aging 1(2):127\u2013131","journal-title":"Neurobiol Aging"},{"key":"1809_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s40473-019-00179-0","volume":"6","author":"PJ Flannery","year":"2019","unstructured":"Flannery PJ, Trushina E (2019) Mitochondrial dysfunction in Alzheimer\u2019s disease and progress in mitochondria-targeted therapeutics. Curr Behav Neurosci Rep 6:88\u2013102","journal-title":"Curr Behav Neurosci Rep"},{"issue":"8","key":"1809_CR32","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1212\/WNL.33.8.961","volume":"33","author":"NL Foster","year":"1983","unstructured":"Foster NL, Chase TN, Fedio P, Patronas NJ, Brooks RA, Di Chiro G (1983) Alzheimer\u2019s disease: focal cortical changes shown by positron emission tomography. Neurology 33(8):961\u2013961","journal-title":"Neurology"},{"issue":"5","key":"1809_CR33","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0197-4580(87)90037-6","volume":"8","author":"GB Freeman","year":"1987","unstructured":"Freeman GB, Nielsen PE, Gibson GE (1987a) Effect of age on behavioral and enzymatic changes during Thiamin deficiency. Neurobiol Aging 8(5):429\u2013434","journal-title":"Neurobiol Aging"},{"issue":"4","key":"1809_CR34","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/00004728-198308000-00003","volume":"7","author":"RP Friedland","year":"1983","unstructured":"Friedland RP, Budinger TF, Ganz E, Yano Y, Mathis CA, Koss B, Ober BA, Huesman RH, Derenzo SE (1983) Regional cerebral metabolic alterations in dementia of the alzheimer type: positron emission tomography with [18F] Fluorodeoxyglucose. J Comput Assist Tomogr 7(4):590\u2013598","journal-title":"J Comput Assist Tomogr"},{"issue":"3","key":"1809_CR35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3233\/JAD-2001-3308","volume":"3","author":"GE Gibson","year":"2001","unstructured":"Gibson GE, Zhang H (2001) Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer\u2019s disease. J Alzheimers Dis 3(3):329\u2013338","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1809_CR36","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1749-6632.1982.tb31213.x","volume":"378","author":"G Gibson","year":"1982","unstructured":"Gibson G, Barclay L, Blass J (1982) The role of the cholinergic system in thiamin deficiency. Ann N Y Acad Sci 378(1):382\u2013403","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"1809_CR37","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1001\/archneur.1988.00520320022009","volume":"45","author":"GE Gibson","year":"1988","unstructured":"Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, Perrino P (1988) Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer\u2019s disease. Arch Neurol 45(8):836\u2013840","journal-title":"Arch Neurol"},{"issue":"2","key":"1809_CR38","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1017\/S1041610291000820","volume":"3","author":"GE Gibson","year":"1991","unstructured":"Gibson GE, Blass JP, Huang H-M, Freeman GB (1991) The cellular basis of delirium and its relevance to age-related disorders including Alzheimer\u2019s disease. Int Psychogeriatr 3(2):373\u2013395","journal-title":"Int Psychogeriatr"},{"issue":"1","key":"1809_CR39","first-page":"122","volume":"1802","author":"GE Gibson","year":"2010","unstructured":"Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF (2010) Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Et Biophys Acta (BBA)-Molecular Basis Disease 1802(1):122\u2013134","journal-title":"Biochim Et Biophys Acta (BBA)-Molecular Basis Disease"},{"key":"1809_CR40","first-page":"1121e1113","volume":"33","author":"G Gibson","year":"2011","unstructured":"Gibson G, Lian H, Xu H, Qiu L, xu Z, Denton T, Shi Q (2011) Deficits in the mitochondrial enzyme \u03b1-ketoglutarate dehydrogenase lead to Alzheimer\u2019s disease-like calcium dysregulation. Neurobiol Aging 33:1121e1113-1121e1124","journal-title":"Neurobiol Aging"},{"issue":"6","key":"1809_CR41","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.neurobiolaging.2011.11.003","volume":"33","author":"GE Gibson","year":"2012","unstructured":"Gibson GE, Chen H-L, Xu H, Qiu L, Xu Z, Denton TT, Shi Q (2012) Deficits in the mitochondrial enzyme \u03b1-ketoglutarate dehydrogenase lead to alzheimer\u2019s disease-like calcium dysregulation. Neurobiol Aging 33(6):1121 e1113\u20131121. e1124","journal-title":"Neurobiol Aging"},{"issue":"3","key":"1809_CR42","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF00972141","volume":"12","author":"JF Gigu\u00e8re","year":"1987","unstructured":"Gigu\u00e8re JF, Butterworth RF (1987) Activities of thiamine-dependent enzymes in two experimental models of thiamine deficiency encephalopathy: 3. transketolase. Neurochem Res 12(3):305\u2013310","journal-title":"Neurochem Res"},{"key":"1809_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2024.102857","volume":"86","author":"C Glynn","year":"2024","unstructured":"Glynn C, Rodriguez JA, Hyman BT (2024) The structural line between prion and \u201cprion-like\u201d: insights from prion protein and tau. Curr Opin Neurobiol 86:102857","journal-title":"Curr Opin Neurobiol"},{"key":"1809_CR44","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fneur.2013.00072","volume":"4","author":"J G\u00f6tz","year":"2013","unstructured":"G\u00f6tz J, Xia D, Leinenga G, Chew YL, Nicholas H (2013) What renders TAU toxic. Front Neurol 4:72","journal-title":"Front Neurol"},{"issue":"1","key":"1809_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.46.1.173","volume":"46","author":"JW Greenawalt","year":"1970","unstructured":"Greenawalt JW, Schnaitman C (1970) An appraisal of the use of monoamine oxidase as an enzyme marker for the outer membrane of rat liver mitochondria. J Cell Biol 46(1):173\u2013179","journal-title":"J Cell Biol"},{"issue":"5","key":"1809_CR46","first-page":"2553","volume":"16","author":"S Gudimetla","year":"2025","unstructured":"Gudimetla S, Mohan RK (2025) Impairment of tricarboxylic acid cycle (TCA) cycle in alzheimer\u2019s disease: mechanisms, implications, and potential therapies. Aging Dis 16(5):2553\u20132574","journal-title":"Aging Dis"},{"key":"1809_CR47","doi-asserted-by":"crossref","unstructured":"Hansen GE, Gibson GE (2022) The \u03b1-Ketoglutarate dehydrogenase complex as a hub of plasticity in neurodegeneration and regeneration. Int J Mol Sci 23(20)","DOI":"10.3390\/ijms232012403"},{"issue":"5054","key":"1809_CR48","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256(5054):184\u2013185","journal-title":"Science"},{"issue":"1","key":"1809_CR49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF00995157","volume":"20","author":"M H\u00e9roux","year":"1995","unstructured":"H\u00e9roux M, Butterworth RF (1995) Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental wernicke\u2019s encephalopathy. Neurochem Res 20(1):87\u201393","journal-title":"Neurochem Res"},{"issue":"8","key":"1809_CR50","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1128\/MCB.26.8.3071-3084.2006","volume":"26","author":"P Hu","year":"2006","unstructured":"Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH (2006) Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1\u03b1-mediated NF-\u03baB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26(8):3071\u20133084","journal-title":"Mol Cell Biol"},{"issue":"1","key":"1809_CR51","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0925-4439(02)00222-3","volume":"1637","author":"HM Huang","year":"2003","unstructured":"Huang HM, Zhang H, Xu H, Gibson GE (2003) Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. Biochim Biophys Acta 1637(1):119\u2013126","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1809_CR52","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1):44\u201357","journal-title":"Nat Protoc"},{"issue":"45","key":"1809_CR53","doi-asserted-by":"publisher","first-page":"15835","DOI":"10.1021\/bi981512h","volume":"37","author":"KM Humphries","year":"1998","unstructured":"Humphries KM, Szweda LI (1998) Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 37(45):15835\u201315841","journal-title":"Biochemistry"},{"issue":"2","key":"1809_CR54","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1021\/bi971958i","volume":"37","author":"KM Humphries","year":"1998","unstructured":"Humphries KM, Yoo Y, Szweda LI (1998) Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry 37(2):552\u2013557","journal-title":"Biochemistry"},{"key":"1809_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1206688","volume":"17","author":"D Jia","year":"2023","unstructured":"Jia D, Wang F, Yu H (2023) Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer\u2019s disease. Front Neurosci 17:1206688","journal-title":"Front Neurosci"},{"issue":"22","key":"1809_CR56","doi-asserted-by":"publisher","first-page":"10964","DOI":"10.1073\/pnas.89.22.10964","volume":"89","author":"GL Johanning","year":"1992","unstructured":"Johanning GL, Morris JI, Madhusudhan KT, Samols D, Patel MS (1992) Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene. Proc Natl Acad Sci U S A 89(22):10964\u201310968","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1809_CR57","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1097\/00005072-197007000-00009","volume":"29","author":"AB Johnson","year":"1970","unstructured":"Johnson AB, Blum NR (1970) Nucleoside phosphatase activities associated with the tangles and plaques of Alzheimer\u2019s disease: a histochemical study of natural and experimental neurofibrillary tangles. J Neuropathol Exp Neurol 29(3):463\u2013478","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"1809_CR58","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12079-021-00663-x","volume":"16","author":"AFO Justo","year":"2022","unstructured":"Justo AFO, Suemoto CK (2022) The modulation of neuroinflammation by inducible nitric oxide synthase. J Cell Commun Signal 16(2):155\u2013158","journal-title":"J Cell Commun Signal"},{"issue":"1","key":"1809_CR59","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"1809_CR60","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ana.410200205","volume":"20","author":"T Kitamoto","year":"1986","unstructured":"Kitamoto T, Tateishi J, Tashima T, Takeshita I, Barry RA, DeArmond SJ, Prusiner SB (1986) Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies. Ann Neurol 20(2):204\u2013208","journal-title":"Ann Neurol"},{"issue":"1","key":"1809_CR61","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ana.410430121","volume":"43","author":"T Kobayashi","year":"1998","unstructured":"Kobayashi T, Matsumine H, Matuda S, Mizuno Y (1998) Association between the gene encoding the E2 subunit of the \u03b1-ketoglutarate dehydrogenase complex and parkinson\u2019s disease. Ann Neurol 43(1):120\u2013123","journal-title":"Ann Neurol"},{"issue":"10","key":"1809_CR62","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1016\/j.bbadis.2016.12.020","volume":"1863","author":"AV Kozlov","year":"2017","unstructured":"Kozlov AV, Bahrami S, Redl H, Szabo C (2017) Alterations in nitric oxide homeostasis during traumatic brain injury. Biochimica et Biophysica Acta (BBA) 1863(10):2627\u20132632","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"2","key":"1809_CR63","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF02674735","volume":"12","author":"PJ Langlais","year":"1997","unstructured":"Langlais PJ, Anderson G, Guo S, Bondy SC (1997) Increased cerebral free radical production during thiamine deficiency. Metab Brain Dis 12(2):137\u2013143","journal-title":"Metab Brain Dis"},{"issue":"20","key":"1809_CR64","doi-asserted-by":"publisher","first-page":"17727","DOI":"10.1074\/jbc.M212878200","volume":"278","author":"M Levy","year":"2003","unstructured":"Levy M, Faas GC, Saggau P, Craigen WJ, Sweatt JD (2003) Mitochondrial regulation of synaptic plasticity in the hippocampus. J Biol Chem 278(20):17727\u201317734","journal-title":"J Biol Chem"},{"issue":"3","key":"1809_CR65","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","volume":"89","author":"Y Lu","year":"2008","unstructured":"Lu Y, Christian K, Lu B (2008) BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89(3):312\u2013323","journal-title":"Neurobiol Learn Mem"},{"issue":"10","key":"1809_CR66","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1523\/JNEUROSCI.0172-22.2023","volume":"43","author":"F Ma","year":"2023","unstructured":"Ma F, Akolkar H, Xu J, Liu Y, Popova D, Xie J, Youssef MM, Benosman R, Hart RP, Herrup K (2023) The amyloid precursor protein modulates the position and length of the axon initial segment. J Neurosci 43(10):1830\u20131844","journal-title":"J Neurosci"},{"issue":"10","key":"1809_CR67","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70064","volume":"30","author":"X Ma","year":"2024","unstructured":"Ma X, Sun Y, Li C, Wang M, Zang Q, Zhang X, Wang F, Niu Y, Hua J (2024) Novel Insights Into DLAT\u2019s Role in Alzheimer\u2019s Disease-Related Copper Toxicity Through Microglial Exosome Dynamics. CNS Neurosci Ther 30(10):e70064","journal-title":"CNS Neurosci Ther"},{"issue":"1\u20132","key":"1809_CR68","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0014-5793(90)80840-F","volume":"277","author":"E Maas","year":"1990","unstructured":"Maas E, Bisswanger H (1990) Localization of the alpha-oxoacid dehydrogenase multienzyme complexes within the mitochondrion. FEBS Lett 277(1\u20132):189\u2013190","journal-title":"FEBS Lett"},{"issue":"11","key":"1809_CR69","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1093\/hmg\/dds072","volume":"21","author":"M Manczak","year":"2012","unstructured":"Manczak M, Reddy PH (2012a) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer\u2019s disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21(11):2538\u20132547","journal-title":"Hum Mol Genet"},{"issue":"23","key":"1809_CR70","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1093\/hmg\/dds360","volume":"21","author":"M Manczak","year":"2012","unstructured":"Manczak M, Reddy PH (2012b) Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer\u2019s disease. Hum Mol Genet 21(23):5131\u20135146","journal-title":"Hum Mol Genet"},{"issue":"10","key":"1809_CR71","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/nm1007-1140","volume":"13","author":"G Manfredi","year":"2007","unstructured":"Manfredi G, Beal MF (2007) Merging mitochondria for neuronal survival. Nat Med 13(10):1140\u20131141","journal-title":"Nat Med"},{"issue":"1","key":"1809_CR72","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","volume":"68","author":"RJ Mark","year":"1997","unstructured":"Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP (1997) A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem 68(1):255\u2013264","journal-title":"J Neurochem"},{"issue":"5","key":"1809_CR73","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/j.1460-9568.2004.03578.x","volume":"20","author":"A Markham","year":"2004","unstructured":"Markham A, Cameron I, Franklin P, Spedding M (2004) BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II. Eur J Neurosci 20(5):1189\u20131196","journal-title":"Eur J Neurosci"},{"issue":"8696","key":"1809_CR74","first-page":"1037","volume":"335","author":"PL McGeer","year":"1990","unstructured":"McGeer PL, McGeer E, Rogers J, Sibley J (1990) Anti-inflammatory Drugs Alzheimer Disease Lancet 335(8696):1037","journal-title":"Anti-inflammatory Drugs Alzheimer Disease Lancet"},{"issue":"2","key":"1809_CR75","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ana.410350212","volume":"35","author":"Y Mizuno","year":"1994","unstructured":"Mizuno Y, Matuda S, Yoshino H, Mori H, Hattori N, Ikebe SI (1994) An immunohistochemical study on \u03b1-ketoglutarate dehydrogenase complex in parkinson\u2019s disease. Annals Neurology: Official J Am Neurol Association Child Neurol Soc 35(2):204\u2013210","journal-title":"Annals Neurology: Official J Am Neurol Association Child Neurol Soc"},{"issue":"6","key":"1809_CR76","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1007\/s12035-024-04468-y","volume":"62","author":"MHED Moawad","year":"2025","unstructured":"Moawad MHED, Serag I, Alkhawaldeh IM, Abbas A, Sharaf A, Alsalah S, Sadeq MA, Shalaby MMM, Hefnawy MT, Abouzid M, Meshref M (2025) Exploring the mechanisms and therapeutic approaches of mitochondrial dysfunction in Alzheimer\u2019s disease: an educational literature review. Mol Neurobiol 62(6):6785\u20136810","journal-title":"Mol Neurobiol"},{"issue":"6","key":"1809_CR77","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/NEN.0000000000000197","volume":"74","author":"NN Naseri","year":"2015","unstructured":"Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE (2015) Abnormalities in the tricarboxylic acid cycle in huntington disease and in a huntington disease mouse model. J Neuropathol Exp Neurol 74(6):527\u2013537","journal-title":"J Neuropathol Exp Neurol"},{"key":"1809_CR78","doi-asserted-by":"publisher","DOI":"10.3390\/life11050407","author":"NS Nemeria","year":"2021","unstructured":"Nemeria NS, Zhang X, Leandro J, Zhou J, Yang L, Houten SM, Jordan F (2021) Toward an understanding of the structural and mechanistic aspects of protein-protein interactions in 2-oxoacid dehydrogenase complexes. Life. https:\/\/doi.org\/10.3390\/life11050407","journal-title":"Life"},{"issue":"26","key":"1809_CR79","doi-asserted-by":"publisher","first-page":"23357","DOI":"10.1074\/jbc.M100320200","volume":"276","author":"AC Nulton-Persson","year":"2001","unstructured":"Nulton-Persson AC, Szweda LI (2001) Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem 276(26):23357\u201323361","journal-title":"J Biol Chem"},{"key":"1809_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/biom11111598","author":"A Pal","year":"2021","unstructured":"Pal A, Rani I, Pawar A, Picozza M, Rongioletti M, Squitti R (2021) Microglia and astrocytes in Alzheimer\u2019s disease in the context of the aberrant copper homeostasis hypothesis. Biomolecules. https:\/\/doi.org\/10.3390\/biom11111598","journal-title":"Biomolecules"},{"key":"1809_CR81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084065","author":"D Pamies","year":"2021","unstructured":"Pamies D, Sartori C, Schvartz D, Gonz\u00e1lez-Ruiz V, Pellerin L, Nunes C, Tavel D, Maillard V, Boccard J, Rudaz S, Sanchez JC, Zurich MG (2021) Neuroinflammatory response to TNF\u03b1 and IL1\u03b2 cytokines is accompanied by an increase in glycolysis in human astrocytes in vitro. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22084065","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1809_CR82","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1046\/j.1471-4159.1999.0721948.x","volume":"72","author":"LC Park","year":"1999","unstructured":"Park LC, Zhang H, Sheu KF, Calingasan NY, Kristal BS, Lindsay JG, Gibson GE (1999) Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J Neurochem 72(5):1948\u20131958","journal-title":"J Neurochem"},{"issue":"5","key":"1809_CR83","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1002\/jnr.10062","volume":"66","author":"LC Park","year":"2001","unstructured":"Park LC, Albers DS, Xu H, Lindsay JG, Beal MF, Gibson GE (2001) Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. J Neurosci Res 66(5):1028\u20131034","journal-title":"J Neurosci Res"},{"issue":"44","key":"1809_CR84","doi-asserted-by":"publisher","first-page":"10220","DOI":"10.1523\/JNEUROSCI.2773-05.2005","volume":"25","author":"SE Perez","year":"2005","unstructured":"Perez SE, Lazarov O, Koprich JB, Chen E-Y, Rodriguez-Menendez V, Lipton JW, Sisodia SS, Mufson EJ (2005) Nigrostriatal dysfunction in familial alzheimer\u2019s disease-linked APPswe\/PS1\u2206E9 transgenic mice. J Neurosci 25(44):10220\u201310229","journal-title":"J Neurosci"},{"key":"1809_CR85","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.1523\/JNEUROSCI.5572-07.2008","volume":"28","author":"J Petravicz","year":"2008","unstructured":"Petravicz J, Fiacco T, McCarthy K (2008) Loss of IP3 receptor-dependent Ca2\u2009+\u2009increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. J Neuroscience: Official J Soc Neurosci 28:4967\u20134973","journal-title":"J Neuroscience: Official J Soc Neurosci"},{"issue":"2 Pt 1","key":"1809_CR86","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0092-8674(83)90168-X","volume":"35","author":"SB Prusiner","year":"1983","unstructured":"Prusiner SB, McKinley MP, Bowman KA, Bolton DC, Bendheim PE, Groth DF, Glenner GG (1983) Scrapie prions aggregate to form amyloid-like birefringent rods. Cell 35(2 Pt 1):349\u2013358","journal-title":"Cell"},{"key":"1809_CR87","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00419","volume":"12","author":"MO Quartey","year":"2018","unstructured":"Quartey MO, Nyarko JN, Pennington PR, Heistad RM, Klassen PC, Baker GB, Mousseau DD (2018) Alzheimer disease and selected risk factors disrupt a co-regulation of monoamine oxidase-A\/B in the hippocampus, but not in the cortex. Front Neurosci 12:419","journal-title":"Front Neurosci"},{"issue":"12","key":"1809_CR88","doi-asserted-by":"publisher","first-page":"8312","DOI":"10.1074\/jbc.M113.545301","volume":"289","author":"CL Quinlan","year":"2014","unstructured":"Quinlan CL, Goncalves RL, Hey-Mogensen M, Yadava N, Bunik VI, Brand MD (2014) The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide\/hydrogen peroxide at much higher rates than complex I. J Biol Chem 289(12):8312\u20138325","journal-title":"J Biol Chem"},{"issue":"9","key":"1809_CR89","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrm3412","volume":"13","author":"R Rizzuto","year":"2012","unstructured":"Rizzuto R, De Stefani D, Raffaello A, Mammucari C (2012) Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol 13(9):566\u2013578","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1809_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.05.001","volume":"131","author":"A Salminen","year":"2015","unstructured":"Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M (2015) Impaired mitochondrial energy metabolism in Alzheimer\u2019s disease: impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog Neurobiol 131:1\u201320","journal-title":"Prog Neurobiol"},{"key":"1809_CR91","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102343","author":"ZA S\u00e1nchez-Florentino","year":"2024","unstructured":"S\u00e1nchez-Florentino ZA, Romero-Mart\u00ednez BS, Flores-Soto E, Monta\u00f1o LM, Sommer B, Vald\u00e9s-Tovar M, Argueta J, Calixto E, Aquino-G\u00e1lvez A, Castillejos-L\u00f3pez M, Serrano H, Gomez-Verjan JC, L\u00f3pez-Riquelme GO, Ben\u00edtez-King GA, Jaimez R, Sol\u00eds-Chagoy\u00e1n H (2024) Altered PLC\u03b2\/IP3\/Ca2\u2009+\u2009signaling pathway activated by GPRCs in olfactory neuronal precursor cells derived from patients diagnosed with schizophrenia. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12102343","journal-title":"Biomedicines"},{"key":"1809_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00115","volume":"10","author":"CD SanMart\u00edn","year":"2017","unstructured":"SanMart\u00edn CD, Veloso P, Adasme T, Lobos P, Bruna B, Galaz J, Garc\u00eda A, Hartel S, Hidalgo C, Paula-Lima AC (2017) RyR2-mediated Ca(2+) release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid \u03b2 peptide oligomers. Front Mol Neurosci 10:115","journal-title":"Front Mol Neurosci"},{"key":"1809_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111944","volume":"168","author":"F Sayehmiri","year":"2022","unstructured":"Sayehmiri F, Khodagholi F, Pourbadie HG, Naderi N, Aliakbarzadeh F, Hashemi R, Naderi S, Motamedi F (2022) Phosphonate analog of 2-oxoglutarate regulates glutamate-glutamine homeostasis and counteracts amyloid beta induced learning and memory deficits in rats. Exp Gerontol 168:111944","journal-title":"Exp Gerontol"},{"issue":"8","key":"1809_CR94","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14897","volume":"30","author":"F Sayehmiri","year":"2024","unstructured":"Sayehmiri F, Motamedi F, Batool Z, Naderi N, Shaerzadeh F, Zoghi A, Rezaei O, Khodagholi F, Pourbadie HG (2024) Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer\u2019s disease. CNS Neuroscience & Therapeutics 30(8):e14897","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"S1 1","key":"1809_CR95","first-page":"S89","volume":"44","author":"A Schapira","year":"1998","unstructured":"Schapira A, Gu M, Taanman JW, Tabrizi S, Seaton T, Cleeter M, Cooper J (1998) Mitochondria in the etiology and pathogenesis of Parkinson\u2019s disease. Ann Neurol 44(S1 1):S89\u2013S98","journal-title":"Ann Neurol"},{"key":"1809_CR96","doi-asserted-by":"crossref","unstructured":"Schrank S, Barrington N, Stutzmann GE (2020) Calcium-handling defects and neurodegenerative disease. Cold Spring Harb Perspect Biol 12(7)","DOI":"10.1101\/cshperspect.a035212"},{"issue":"4","key":"1809_CR97","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s004010050533","volume":"92","author":"C Schwab","year":"1996","unstructured":"Schwab C, Steele JC, Akiyama H, McGeer PL (1996) Distinct distribution of apolipoprotein E and \u03b2-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam. Acta Neuropathol 92(4):378\u2013385","journal-title":"Acta Neuropathol"},{"issue":"11","key":"1809_CR98","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"1809_CR99","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1749-6632.1999.tb07818.x","volume":"893","author":"KF Sheu","year":"1999","unstructured":"Sheu KF, Blass JP (1999) The alpha-ketoglutarate dehydrogenase complex. Ann N Y Acad Sci 893:61\u201378","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"1809_CR100","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1046\/j.1471-4159.1996.67020684.x","volume":"67","author":"KFR Sheu","year":"1996","unstructured":"Sheu KFR, Calingasan NY, Dienel GA, Baker H, Jung EH, Kim KS, Paoletti F, Gibson GE (1996) Regional reductions of transketolase in thiamine-deficient rat brain. J Neurochem 67(2):684\u2013691","journal-title":"J Neurochem"},{"issue":"3","key":"1809_CR101","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1046\/j.1471-4159.1998.70031143.x","volume":"70","author":"KF Sheu","year":"1998","unstructured":"Sheu KF, Calingasan NY, Lindsay JG, Gibson GE (1998a) Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. J Neurochem 70(3):1143\u20131150","journal-title":"J Neurochem"},{"key":"1809_CR102","first-page":"338","volume":"2","author":"L Sokoloff","year":"1989","unstructured":"Sokoloff L (1989) Circulation and energy metabolism of the brain. Basic Neurochem 2:338\u2013413","journal-title":"Basic Neurochem"},{"key":"1809_CR103","doi-asserted-by":"crossref","unstructured":"Sonar SA, Lal G (2019) The iNOS activity during an immune response controls the CNS pathology in experimental autoimmune encephalomyelitis. Front Immunol 10\u20132019","DOI":"10.3389\/fimmu.2019.00710"},{"issue":"1","key":"1809_CR104","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-024-00409-w","volume":"13","author":"N Song","year":"2024","unstructured":"Song N, Mei S, Wang X, Hu G, Lu M (2024) Focusing on mitochondria in the brain: from biology to therapeutics. Transl Neurodegener 13(1):23","journal-title":"Transl Neurodegener"},{"key":"1809_CR105","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mcn.2012.07.005","volume":"55","author":"AA Starkov","year":"2013","unstructured":"Starkov AA (2013) An update on the role of mitochondrial \u03b1-ketoglutarate dehydrogenase in oxidative stress. Mol Cell Neurosci 55:13\u201316","journal-title":"Mol Cell Neurosci"},{"issue":"5","key":"1809_CR106","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1177\/1073858407299730","volume":"13","author":"GE Stutzmann","year":"2007","unstructured":"Stutzmann GE (2007) The pathogenesis of alzheimers disease is it a lifelong calciumopathy? Neuroscientist 13(5):546\u2013559","journal-title":"Neuroscientist"},{"key":"1809_CR107","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","volume":"62","author":"R Swerdlow","year":"2017","unstructured":"Swerdlow R (2017) Mitochondria and mitochondrial cascades in alzheimer\u2019s disease. J Alzheimers Dis 62:1403\u20131416","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1809_CR108","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","volume":"63","author":"RH Swerdlow","year":"2004","unstructured":"Swerdlow RH, Khan SM (2004) A mitochondrial cascade hypothesis for sporadic alzheimer\u2019s disease. Med Hypotheses 63(1):8\u201320","journal-title":"Med Hypotheses"},{"issue":"16","key":"1809_CR109","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1093\/hmg\/9.16.2383","volume":"9","author":"J Theuns","year":"2000","unstructured":"Theuns J, Van Broeckhoven C (2000) Transcriptional regulation of Alzheimer\u2019s disease genes: implications for susceptibility. Hum Mol Genet 9(16):2383\u20132394","journal-title":"Hum Mol Genet"},{"issue":"7684","key":"1809_CR110","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nature25003","volume":"552","author":"Y Wang","year":"2017","unstructured":"Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z (2017) KAT2A coupled with the \u03b1-KGDH complex acts as a histone H3 succinyltransferase. Nature 552(7684):273\u2013277","journal-title":"Nature"},{"issue":"5","key":"1809_CR111","first-page":"5844","volume":"12","author":"C Wang","year":"2019","unstructured":"Wang C, Li T, Zhao D (2019) Correlation of alpha-KGDHC activity with mild hypothermia treatment of acute brain injuries. Int J Clin Exp Med 12(5):5844\u20135851","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"1809_CR112","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Zhao F, Ma X, Perry G, Zhu X (2020) Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances. Mol Neurodegener 15(1):30","journal-title":"Mol Neurodegener"},{"key":"1809_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102669","volume":"62","author":"A Weidinger","year":"2023","unstructured":"Weidinger A, Milivojev N, Hosmann A, Duvigneau JC, Szabo C, T\u00f6r\u00f6 G, Rauter L, Vaglio-Garro A, Mkrtchyan GV, Trofimova L, Sharipov RR, Surin AM, Krasilnikova IA, Pinelis VG, Tretter L, Moldzio R, Bay\u0131r H, Kagan VE, Bunik VI, Kozlov AV (2023) Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death. Redox Biol 62:102669","journal-title":"Redox Biol"},{"issue":"2","key":"1809_CR114","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1006\/niox.2001.0399","volume":"6","author":"KS Williamson","year":"2002","unstructured":"Williamson KS, Gabbita SP, Mou S, West M, Pye QN, Markesbery WR, Cooney RV, Grammas P, Reimann-Philipp U, Floyd RA, Hensley K (2002) The nitration product 5-nitro-gamma-tocopherol is increased in the alzheimer brain. Nitric Oxide 6(2):221\u2013227","journal-title":"Nitric Oxide"},{"issue":"2","key":"1809_CR115","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00005072-197004000-00001","volume":"29","author":"H Wi\u015bniewski","year":"1970","unstructured":"Wi\u015bniewski H, Terry RD, Hirano A (1970) Neurofibrillary pathology. J Neuropathol Exp Neurol 29(2):163\u2013176","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"1809_CR116","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.14336\/AD.2019.1125","volume":"11","author":"KY Wong","year":"2020","unstructured":"Wong KY, Roy J, Fung ML, Heng BC, Zhang C, Lim LW (2020) Relationships between mitochondrial dysfunction and neurotransmission failure in alzheimer\u2019s disease. Aging Dis 11(5):1291","journal-title":"Aging Dis"},{"issue":"10","key":"1809_CR117","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101816","volume":"12","author":"Y-H Wu","year":"2023","unstructured":"Wu Y-H, Hsieh H-L (2023) Effects of redox homeostasis and mitochondrial damage on Alzheimer\u2019s disease. Antioxidants 12(10):1816","journal-title":"Antioxidants"},{"issue":"7","key":"1809_CR118","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1111\/j.1460-9568.2004.03246.x","volume":"19","author":"A Wu","year":"2004","unstructured":"Wu A, Ying Z, Gomez-Pinilla F (2004) The interplay between oxidative stress and brain\u2010derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19(7):1699\u20131707","journal-title":"Eur J Neurosci"},{"issue":"1","key":"1809_CR119","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41467-021-27572-2","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, Anderson ET, Ivanova E, Lin H, Sagdullaev BT, Chen J, Klein WL, Viola KL, Gandy S, Haroutunian V, Beal MF, Eliezer D, Zhang S, Gibson GE (2022) Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer\u2019s disease. Nat Commun 13(1):159","journal-title":"Nat Commun"},{"issue":"4","key":"1809_CR120","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1083\/jcb.201607099","volume":"215","author":"X Yin","year":"2016","unstructured":"Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD (2016) Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol 215(4):531\u2013542","journal-title":"J Cell Biol"},{"issue":"7203","key":"1809_CR121","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454(7203):455\u2013462","journal-title":"Nature"},{"issue":"1","key":"1809_CR122","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-024-00429-6","volume":"13","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wang J, Zhang Z, Ye K (2024) Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Transl Neurodegener 13(1):40","journal-title":"Transl Neurodegener"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01809-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01809-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01809-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:02:30Z","timestamp":1775552550000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01809-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":122,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1809"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01809-9","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"8 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"77"}}