{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:59:43Z","timestamp":1775041183607,"version":"3.50.1"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zydus Research Center"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01839-3","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:44:17Z","timestamp":1775018657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GLP-1 and the brain\u2019s powerhouse: a new perspective on the role of mitochondria in neuroprotection"],"prefix":"10.1007","volume":"41","author":[{"given":"Tiasha","family":"Dasgupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Bhayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnarup","family":"Ghoshdastidar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasinath","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"12","key":"1839_CR1","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1002\/jnr.24075","volume":"95","author":"C Acosta","year":"2017","unstructured":"Acosta C, Anderson HD, Anderson CM (2017) Astrocyte dysfunction in Alzheimer disease. J Neurosci Res 95(12):2430\u20132447","journal-title":"J Neurosci Res"},{"key":"1839_CR2","doi-asserted-by":"crossref","unstructured":"Ajaz S, McPhail MJ, Gnudi L, Trovato FM, Mujib S, Napoli S et al (2021) Mitochondrial dysfunction as a mechanistic biomarker in patients with non-alcoholic fatty liver disease (NAFLD). Mitochondrion [Internet] 57:119\u201330. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1567724920302415","DOI":"10.1016\/j.mito.2020.12.010"},{"issue":"4","key":"1839_CR3","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3390\/cimb47040285","volume":"47","author":"M Al Qassab","year":"2025","unstructured":"Al Qassab M, Mneimneh M, Jradi A, Derbas B, Dabboussi D, Khoury Baini J et al (2025) The expanding role of GLP-1 receptor agonists: advancing clinical outcomes in metabolic and mental health. Curr Issues Mol Biol 47(4):285","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"1839_CR4","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1104\/pp.17.01025","volume":"176","author":"S-I Arimura","year":"2018","unstructured":"Arimura S-I (2018) Fission and fusion of plant mitochondria, and genome maintenance. Plant Physiol 176(1):152\u2013161","journal-title":"Plant Physiol"},{"issue":"3","key":"1839_CR5","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3390\/cimb46030130","volume":"46","author":"S Bartman","year":"2024","unstructured":"Bartman S, Coppotelli G, Ross JM (2024) Mitochondrial dysfunction: a key player in brain aging and diseases. Curr Issues Mol Biol 46(3):1987\u20132026","journal-title":"Curr Issues Mol Biol"},{"key":"1839_CR6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fneur.2015.00182","volume":"6","author":"A Bassi","year":"2015","unstructured":"Bassi A, Bozzali M (2015) Potential interactions between the autonomic nervous system and higher level functions in neurological and neuropsychiatric conditions. Front Neurol 6:182","journal-title":"Front Neurol"},{"issue":"5","key":"1839_CR7","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","volume":"1863","author":"JS Bhatti","year":"2017","unstructured":"Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis 1863(5):1066\u20131077","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1839_CR8","doi-asserted-by":"publisher","first-page":"111575","DOI":"10.1016\/j.mad.2021.111575","volume":"200","author":"Y Blinkouskaya","year":"2021","unstructured":"Blinkouskaya Y, Ca\u00e7oilo A, Gollamudi T, Jalalian S, Weickenmeier J (2021) Brain aging mechanisms with mechanical manifestations. Mech Ageing Dev 200:111575","journal-title":"Mech Ageing Dev"},{"key":"1839_CR9","doi-asserted-by":"crossref","unstructured":"Boulos L-J (2024) The brain digitalization: it\u2019s all happening so fast! Front Hum Dyn [Internet] 6. Available from: https:\/\/www.frontiersin.org\/journals\/human-dynamics\/articles\/10.3389\/fhumd.2024.1475438","DOI":"10.3389\/fhumd.2024.1475438"},{"issue":"1","key":"1839_CR10","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3390\/cells9010150","volume":"9","author":"Q Cai","year":"2020","unstructured":"Cai Q, Jeong YY (2020) Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative diseases. Cells. 9(1):150","journal-title":"Cells."},{"issue":"4","key":"1839_CR11","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3892\/mmr.2012.746","volume":"5","author":"M Cao","year":"2012","unstructured":"Cao M, Jiang J, Du Y, Yan P (2012) Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells. Mol Med Rep 5(4):929\u2013934","journal-title":"Mol Med Rep"},{"issue":"1","key":"1839_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"W Chen","year":"2023","unstructured":"Chen W, Zhao H, Li Y (2023) Mitochondrial dynamics in health and disease: mechanisms and potential targets. Signal Transduct Target Ther 8(1):333. https:\/\/doi.org\/10.1038\/s41392-023-01547-9","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1839_CR13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3892\/ijmm.2025.5546","volume":"56","author":"R Chen","year":"2025","unstructured":"Chen R, Chen W, Li P, Zhao Y, Zeng Q, Chen W et al (2025) Function and application of brain-derived neurotrophic factor precursors. Int J Mol Med 56(1):105","journal-title":"Int J Mol Med"},{"key":"1839_CR14","doi-asserted-by":"crossref","unstructured":"Chen B, Yu X, Horvath-Diano C, Ortu\u00f1o MJ, Tsch\u00f6p MH, Jastreboff AM et al (2024) GLP-1 programs the neurovascular landscape. Cell Metab [Internet] 36(10):2173\u201389. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S155041312400367X","DOI":"10.1016\/j.cmet.2024.09.003"},{"issue":"5","key":"1839_CR15","doi-asserted-by":"publisher","first-page":"e00045","DOI":"10.1042\/AN20100019","volume":"2","author":"A Cheng","year":"2010","unstructured":"Cheng A, Hou Y, Mattson MP (2010) Mitochondria and neuroplasticity. ASN Neuro 2(5):e00045","journal-title":"ASN Neuro"},{"key":"1839_CR16","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/ncomms2238","volume":"3","author":"A Cheng","year":"2012","unstructured":"Cheng A, Wan R, Yang J-L, Kamimura N, Son TG, Ouyang X et al (2012) Involvement of PGC-1\u03b1 in the formation and maintenance of neuronal dendritic spines. Nat Commun 3:1250","journal-title":"Nat Commun"},{"key":"1839_CR17","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2147\/DDDT.S348055","volume":"16","author":"D Cheng","year":"2023","unstructured":"Cheng D, Yang S, Zhao X, Wang G (2023) The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in diabetes-related neurodegenerative diseases. Drug Des Devel Ther 16:665\u201384","journal-title":"Drug Des Devel Ther"},{"key":"1839_CR18","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3390\/ijms10062510","volume":"10","author":"YE Choonara","year":"2009","unstructured":"Choonara YE, Pillay V, Du Toit LC, Modi G, Naidoo D, Ndesendo VMK et al (2009) Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. Int J Mol Sci 10:2510\u20132557","journal-title":"Int J Mol Sci"},{"key":"1839_CR19","first-page":"254248232513421","volume":"9","author":"M Chuansangeam","year":"2025","unstructured":"Chuansangeam M, Phadungsaksawasdi P, Park HJ, Yang Y-H (2025) Exploring the link between GLP-1 receptor agonists and dementia: a comprehensive review. J Alzheimer\u2019s Dis Reports 9:25424823251342184","journal-title":"J Alzheimer\u2019s Dis Reports"},{"issue":"4","key":"1839_CR20","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.kint.2020.09.037","volume":"99","author":"AJ Clark","year":"2021","unstructured":"Clark AJ, Parikh SM (2021) Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1\u03b1. Kidney Int 99(4):828\u2013840","journal-title":"Kidney Int"},{"issue":"9","key":"1839_CR21","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.3390\/biomedicines11092488","volume":"11","author":"VJ Clemente-Su\u00e1rez","year":"2023","unstructured":"Clemente-Su\u00e1rez VJ, Redondo-Fl\u00f3rez L, Beltr\u00e1n-Velasco AI, Ramos-Campo DJ, Belinch\u00f3n-deMiguel P, Martinez-Guardado I et al (2023) Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities. Biomedicines 11(9):2488","journal-title":"Biomedicines"},{"issue":"1","key":"1839_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/cyto.a.23632","volume":"95","author":"A Cong","year":"2019","unstructured":"Cong A, Pimenta RML, Lee HB, Mereddy V, Holy J, Heikal AA (2019) Two-photon fluorescence lifetime imaging of intrinsic NADH in three-dimensional tumor models. Cytom Part A J Int Soc Anal Cytol 95(1):80\u201392","journal-title":"Cytom Part A J Int Soc Anal Cytol"},{"issue":"1","key":"1839_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13195-024-01666-7","volume":"17","author":"JL Cummings","year":"2025","unstructured":"Cummings JL, Atri A, Feldman HH, Hansson O, Sano M, Knop FK et al (2025) Evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer\u2019s disease. Alzheimers Res Ther 17(1):14","journal-title":"Alzheimers Res Ther"},{"key":"1839_CR24","doi-asserted-by":"crossref","unstructured":"D\u2019Alessandro MCB, Kanaan S, Geller M, Pratic\u00f2 D, Daher JPL (2025) Mitochondrial dysfunction in Alzheimer\u2019s disease. Ageing Res Rev [Internet] 107:102713. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163725000595","DOI":"10.1016\/j.arr.2025.102713"},{"issue":"2","key":"1839_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/biomedicines13020279","volume":"13","author":"D Dias","year":"2025","unstructured":"Dias D, Socodato R (2025) Beyond Amyloid and Tau: the critical role of microglia in Alzheimer\u2019s Disease therapeutics. Biomedicines 13(2):279","journal-title":"Biomedicines"},{"issue":"8","key":"1839_CR26","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.4103\/1673-5374.389626","volume":"19","author":"Y Diz-Chaves","year":"2024","unstructured":"Diz-Chaves Y, Maastor Z, Spuch C, Lamas JA, Gonz\u00e1lez-Mat\u00edas LC, Mallo F (2024) Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain. Neural Regen Res 19(8):1671\u20131677","journal-title":"Neural Regen Res"},{"key":"1839_CR27","doi-asserted-by":"crossref","unstructured":"Drucker DJ (2006) The biology of incretin hormones. Cell Metab [Internet] 3(3):153\u201365. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413106000283","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"1839_CR28","doi-asserted-by":"crossref","unstructured":"Drucker DJ (2018) Mechanisms of action and therapeutic application of glucagon-like Peptide-1. Cell Metab [Internet] 27(4):740\u201356. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413118301797","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"1839_CR29","doi-asserted-by":"publisher","first-page":"1033479","DOI":"10.3389\/fendo.2022.1033479","volume":"13","author":"H Du","year":"2022","unstructured":"Du H, Meng X, Yao Y, Xu J (2022) The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer\u2019s disease. Front Endocrinol (Lausanne) 13:1033479","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1839_CR30","doi-asserted-by":"crossref","unstructured":"El Eid L, Reynolds CA, Tomas A, Jones B (2022) Biased agonism and polymorphic variation at the GLP-1 receptor: Implications for the development of personalised therapeutics. Pharmacol Res [Internet]. 184:106411. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661822003565","DOI":"10.1016\/j.phrs.2022.106411"},{"issue":"4","key":"1839_CR31","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1242\/jcs.171017","volume":"130","author":"KH Flippo","year":"2017","unstructured":"Flippo KH, Strack S (2017) Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci 130(4):671\u2013681","journal-title":"J Cell Sci"},{"issue":"23","key":"1839_CR32","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1056\/NEJMra1706158","volume":"379","author":"D Fm","year":"2018","unstructured":"Fm D (2018) Mapping symptoms to brain networks with the human connectome. N Engl J Med [internet] 379(23):2237\u20132245. https:\/\/doi.org\/10.1056\/NEJMra1706158","journal-title":"N Engl J Med [internet]"},{"key":"1839_CR33","doi-asserted-by":"crossref","unstructured":"Gadhave DG, Sugandhi VV, Jha SK, Nangare SN, Gupta G, Singh SK et al (2024) Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance. Ageing Res Rev [Internet] 99:102357. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163724001752","DOI":"10.1016\/j.arr.2024.102357"},{"issue":"8","key":"1839_CR34","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","volume":"90","author":"L Gaetani","year":"2019","unstructured":"Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, Zetterberg H (2019) Neurofilament light chain as a biomarker in neurological disorders. J Neurol Neurosurg Psychiatry 90(8):870\u2013881","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"24","key":"1839_CR35","doi-asserted-by":"publisher","first-page":"9500","DOI":"10.3390\/ijms21249500","volume":"21","author":"M Garofalo","year":"2020","unstructured":"Garofalo M, Pandini C, Bordoni M, Pansarasa O, Rey F, Costa A et al (2020) Alzheimer\u2019s, Parkinson\u2019s disease and amyotrophic lateral sclerosis gene expression patterns divergence reveals different grade of RNA metabolism involvement. Int J Mol Sci. 21(24):9500","journal-title":"Int J Mol Sci."},{"key":"1839_CR36","first-page":"108","volume":"8","author":"M Gejl","year":"2016","unstructured":"Gejl M, Gjedde A, Egefjord L, M\u00f8ller A, Hansen SB, Vang K et al (2016) In Alzheimer\u2019s disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled. Double-Blind Clin Trial Front Aging Neurosci 8:108","journal-title":"Double-Blind Clin Trial Front Aging Neurosci"},{"issue":"5","key":"1839_CR37","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s10237-015-0662-4","volume":"14","author":"A Goriely","year":"2015","unstructured":"Goriely A, Geers MGD, Holzapfel GA, Jayamohan J, J\u00e9rusalem A, Sivaloganathan S et al (2015) Mechanics of the brain: perspectives, challenges, and opportunities. Biomech Model Mechanobiol 14(5):931\u2013965","journal-title":"Biomech Model Mechanobiol"},{"key":"1839_CR38","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1177\/02537176241246744","volume":"46","author":"S Gunturu","year":"2024","unstructured":"Gunturu S (2024) The potential role of GLP-1 agonists in psychiatric disorders: a paradigm shift in mental health treatment. Indian J Psychol Med United States 46:193\u2013195","journal-title":"Indian J Psychol Med United States"},{"issue":"3","key":"1839_CR39","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1152\/physrev.00049.2005","volume":"86","author":"PG Haydon","year":"2006","unstructured":"Haydon PG, Carmignoto G (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86(3):1009\u20131031","journal-title":"Physiol Rev"},{"issue":"2","key":"1839_CR40","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2217\/bmm.10.1","volume":"4","author":"AA Heikal","year":"2010","unstructured":"Heikal AA (2010) Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies. Biomark Med 4(2):241\u2013263","journal-title":"Biomark Med"},{"key":"1839_CR41","doi-asserted-by":"publisher","first-page":"6623","DOI":"10.3390\/ijms22126623","volume":"22","author":"T Hira","year":"2021","unstructured":"Hira T, Trakooncharoenvit A, Taguchi H, Hara H (2021) Improvement of glucose tolerance by food factors having glucagon-like Peptide-1 releasing activity. Int J Mol Sci 22:6623","journal-title":"Int J Mol Sci"},{"issue":"10","key":"1839_CR42","doi-asserted-by":"publisher","first-page":"871","DOI":"10.2165\/11635890-000000000-00000","volume":"26","author":"C H\u00f6lscher","year":"2012","unstructured":"H\u00f6lscher C (2012) Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS Drugs 26(10):871\u2013882","journal-title":"CNS Drugs"},{"key":"1839_CR43","doi-asserted-by":"crossref","unstructured":"H\u00f6lscher C (2024) Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson\u2019s and Alzheimer\u2019s disease clinical trials: A revolution in the making? Neuropharmacology [Internet] 253:109952. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0028390824001217","DOI":"10.1016\/j.neuropharm.2024.109952"},{"issue":"4","key":"1839_CR44","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","volume":"87","author":"JJ Holst","year":"2007","unstructured":"Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87(4):1409\u20131439","journal-title":"Physiol Rev"},{"issue":"1","key":"1839_CR45","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12929-024-01090-x","volume":"31","author":"C-T Hong","year":"2024","unstructured":"Hong C-T, Chen J-H, Hu C-J (2024) Role of glucagon-like peptide-1 receptor agonists in Alzheimer\u2019s disease and Parkinson\u2019s disease. J Biomed Sci 31(1):102. https:\/\/doi.org\/10.1186\/s12929-024-01090-x","journal-title":"J Biomed Sci"},{"key":"1839_CR46","doi-asserted-by":"crossref","unstructured":"Huang EP (1998) Synaptic plasticity: Going through phases with LTP. Curr Biol [Internet] 8(10):R350\u20132. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960982298702192","DOI":"10.1016\/S0960-9822(98)70219-2"},{"issue":"12","key":"1839_CR47","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.2169\/internalmedicine.2489-18","volume":"58","author":"K Ikeda","year":"2019","unstructured":"Ikeda K, Ebina J, Kawabe K, Iwasaki Y (2019) Dopamine transporter imaging in Parkinson disease: progressive changes and therapeutic modification after anti-parkinsonian medications. Intern Med 58(12):1665\u20131672","journal-title":"Intern Med"},{"issue":"1","key":"1839_CR48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jnc.13736","volume":"139","author":"J Jalewa","year":"2016","unstructured":"Jalewa J, Sharma MK, H\u00f6lscher C (2016) Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells. J Neurochem 139(1):55\u201367","journal-title":"J Neurochem"},{"issue":"2","key":"1839_CR49","doi-asserted-by":"publisher","first-page":"C641","DOI":"10.1152\/ajpcell.00222.2006","volume":"292","author":"O Kann","year":"2007","unstructured":"Kann O, Kov\u00e1cs R (2007) Mitochondria and neuronal activity. Am J Physiol Physiol 292(2):C641\u2013C657","journal-title":"Am J Physiol Physiol"},{"issue":"10","key":"1839_CR50","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","volume":"14","author":"M Khalil","year":"2018","unstructured":"Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T et al (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 14(10):577\u2013589","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"1839_CR51","first-page":"e00292","volume":"21","author":"MM Klemmensen","year":"2024","unstructured":"Klemmensen MM, Borrowman SH, Pearce C, Pyles B, Chandra B (2024) Mitochondrial dysfunction in neurodegenerative disorders. Neurother J Am Soc Exp Neurother 21(1):e00292","journal-title":"Neurother J Am Soc Exp Neurother"},{"issue":"8","key":"1839_CR52","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1002\/mds.29456","volume":"38","author":"M Klietz","year":"2023","unstructured":"Klietz M, Mahmoudi N, Maudsley AA, Sheriff S, Bronzlik P, Almohammad M et al (2023) Whole\u2010brain magnetic resonance spectroscopy reveals distinct alterations in neurometabolic profile in progressive supranuclear palsy. Mov Disord 38(8):1503\u20131514","journal-title":"Mov Disord"},{"issue":"1","key":"1839_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh S-H (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Translational Neurodegeneration 9(1):42. https:\/\/doi.org\/10.1186\/s40035-020-00221-2","journal-title":"Translational Neurodegeneration"},{"key":"1839_CR54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-94-007-2869-1_12","volume":"942","author":"E Lezi","year":"2012","unstructured":"Lezi E, Swerdlow RH (2012) Mitochondria in neurodegeneration. Adv Exp Med Biol 942:269\u2013286","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"1839_CR55","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.3233\/JAD-2010-1314","volume":"19","author":"Y Li","year":"2010","unstructured":"Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW et al (2010) GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer\u2019s disease. J Alzheimers Dis 19(4):1205\u20131219","journal-title":"J Alzheimers Dis"},{"key":"1839_CR56","doi-asserted-by":"publisher","first-page":"720085","DOI":"10.3389\/fcvm.2021.720085","volume":"8","author":"J Liu","year":"2021","unstructured":"Liu J, Song X, Yan Y, Liu B (2021) Role of GTPase-dependent mitochondrial dynamins in heart diseases. Front Cardiovasc Med 8:720085","journal-title":"Front Cardiovasc Med"},{"key":"1839_CR57","doi-asserted-by":"crossref","unstructured":"Liu T, Li J, Wu H, Qiao J, Wei J (2025) Unraveling Parkinson\u2019s disease: the mystery of mitochondria and the role of aging. Genes Dis [Internet] 101719. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352304225002089","DOI":"10.1016\/j.gendis.2025.101719"},{"key":"1839_CR58","doi-asserted-by":"crossref","unstructured":"Lv D, Feng P, Guan X, Liu Z, Li D, Xue C et al (2024) Neuroprotective effects of GLP-1 class drugs in Parkinson\u2019s disease. Front Neurol [Internet] 15. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2024.1462240","DOI":"10.3389\/fneur.2024.1462240"},{"key":"1839_CR59","doi-asserted-by":"publisher","first-page":"7239","DOI":"10.3390\/ijms26157239","volume":"26","author":"A Lymperopoulos","year":"2025","unstructured":"Lymperopoulos A, Altsman VL, Stoicovy RA (2025) Glucagon-like Peptide-1 receptor (GLP-1R) signaling: making the case for a functionally Gs protein-selective GPCR. Int J Mol Sci 26:7239","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1839_CR60","doi-asserted-by":"publisher","first-page":"30902","DOI":"10.1063\/5.0055812","volume":"5","author":"BM Maoz","year":"2021","unstructured":"Maoz BM (2021) Brain-on-a-chip: characterizing the next generation of advanced in vitro platforms for modeling the central nervous system. APL Bioeng 5(3):30902","journal-title":"APL Bioeng"},{"issue":"17","key":"1839_CR61","doi-asserted-by":"publisher","first-page":"6587","DOI":"10.1523\/JNEUROSCI.0529-11.2011","volume":"31","author":"PL McClean","year":"2011","unstructured":"McClean PL, Parthsarathy V, Faivre E, H\u00f6lscher C (2011) The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer\u2019s disease. J Neurosci off J Soc Neurosci 31(17):6587\u20136594","journal-title":"J Neurosci off J Soc Neurosci"},{"key":"1839_CR62","doi-asserted-by":"publisher","first-page":"1148209","DOI":"10.3389\/fimmu.2023.1148209","volume":"14","author":"SF Mehdi","year":"2023","unstructured":"Mehdi SF, Pusapati S, Anwar MS, Lohana D, Kumar P, Nandula SA et al (2023) Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Front Immunol 14:1148209","journal-title":"Front Immunol"},{"key":"1839_CR63","doi-asserted-by":"crossref","unstructured":"Moiz A, Filion KB, Tsoukas MA, Yu OHY, Peters TM, Eisenberg MJ (2025) Mechanisms of GLP-1 receptor agonist-induced weight loss: a review of central and peripheral pathways in appetite and energy regulation. Am J Med [Internet] 138(6):934\u201340. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002934325000592","DOI":"10.1016\/j.amjmed.2025.01.021"},{"issue":"7","key":"1839_CR64","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1111\/febs.17338","volume":"292","author":"EV Moo","year":"2025","unstructured":"Moo EV, M\u00f8ller TC, S\u00f8rensen FA, Inoue A, Br\u00e4uner\u2010Osborne H (2025) Arrestin\u2010independent internalization of the GLP\u20101 receptor is facilitated by a GRK, clathrin, and caveolae\u2010dependent mechanism. FEBS J 292(7):1675\u20131695","journal-title":"FEBS J"},{"issue":"3","key":"1839_CR65","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1055\/s-0035-1555115","volume":"36","author":"DL Murman","year":"2015","unstructured":"Murman DL (2015) The impact of age on cognition. Semin Hear 36(3):111\u2013121","journal-title":"Semin Hear"},{"key":"1839_CR66","unstructured":"Next-generation-nlrp3-inhibitors (n.d.) @ www.forever.ai [Internet]. Available from: https:\/\/www.forever.ai\/p\/next-generation-nlrp3-inhibitors"},{"key":"1839_CR67","doi-asserted-by":"publisher","first-page":"636506","DOI":"10.3389\/fcell.2021.636506","volume":"9","author":"V Nicoletti","year":"2021","unstructured":"Nicoletti V, Palermo G, Del Prete E, Mancuso M, Ceravolo R (2021) Understanding the multiple role of mitochondria in Parkinson\u2019s disease and related disorders: lesson from genetics and protein-interaction network. Front Cell Dev Biol 9:636506","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"1839_CR68","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41380-022-01792-4","volume":"28","author":"J Nowell","year":"2023","unstructured":"Nowell J, Blunt E, Edison P (2023) Incretin and insulin signaling as novel therapeutic targets for Alzheimer\u2019s and Parkinson\u2019s disease. Mol Psychiatry 28(1):217\u2013229","journal-title":"Mol Psychiatry"},{"key":"1839_CR69","doi-asserted-by":"publisher","first-page":"12163","DOI":"10.3390\/ijms262412163","volume":"26","author":"MP Orozco","year":"2025","unstructured":"Orozco MP, Vintimilla Rivadeneira V, Leon-Rojas JE (2025) GLP-1 signalling as a therapeutic avenue in Parkinson\u2019s disease: a comprehensive review. Int J Mol Sci 26:12163","journal-title":"Int J Mol Sci"},{"key":"1839_CR70","doi-asserted-by":"publisher","first-page":"175896","DOI":"10.1016\/j.ejphar.2023.175896","volume":"954","author":"S Pandey","year":"2023","unstructured":"Pandey S, Mangmool S, Madreiter-Sokolowski CT, Wichaiyo S, Luangmonkong T, Parichatikanond W (2023) Exendin-4 protects against high glucose-induced mitochondrial dysfunction and oxidative stress in SH-SY5Y neuroblastoma cells through GLP-1 receptor\/Epac\/Akt signaling. Eur J Pharmacol 954:175896","journal-title":"Eur J Pharmacol"},{"key":"1839_CR71","doi-asserted-by":"crossref","unstructured":"Pozo Devoto VM, Onyango IG, Stokin GB (2022) Mitochondrial behavior when things go wrong in the axon. Front Cell Neurosci [Internet] 16. Available from: https:\/\/www.frontiersin.org\/journals\/cellular-neuroscience\/articles\/10.3389\/fncel.2022.959598","DOI":"10.3389\/fncel.2022.959598"},{"key":"1839_CR72","doi-asserted-by":"publisher","first-page":"212283","DOI":"10.7573\/dic.212283","volume":"4","author":"L Prasad-Reddy","year":"2015","unstructured":"Prasad-Reddy L, Isaacs D (2015) A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond. Drugs Context 4:212283","journal-title":"Drugs Context"},{"issue":"5","key":"1839_CR73","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.bbadis.2016.04.017","volume":"1863","author":"S Pugazhenthi","year":"2017","unstructured":"Pugazhenthi S, Qin L, Reddy PH (2017) Common neurodegenerative pathways in obesity, diabetes, and Alzheimer\u2019s disease. Biochimica Et Biophysica Acta (BBA) 1863(5):1037\u20131045","journal-title":"Biochimica Et Biophysica Acta (BBA)"},{"issue":"42","key":"1839_CR74","doi-asserted-by":"publisher","first-page":"8200","DOI":"10.1523\/JNEUROSCI.1157-19.2019","volume":"39","author":"V Rangaraju","year":"2019","unstructured":"Rangaraju V, Lewis TLJ, Hirabayashi Y, Bergami M, Motori E, Cartoni R et al (2019) Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease. J Neurosci off J Soc Neurosci 39(42):8200\u20138208","journal-title":"J Neurosci off J Soc Neurosci"},{"key":"1839_CR75","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/cells14141064","volume":"14","author":"S Reed","year":"2025","unstructured":"Reed S, Taka E, Darling-Reed S, Soliman KFA (2025) Neuroprotective effects of metformin through the modulation of neuroinflammation and oxidative stress. Cells 14:1064","journal-title":"Cells"},{"key":"1839_CR76","doi-asserted-by":"publisher","first-page":"970925","DOI":"10.3389\/fnins.2022.970925","volume":"16","author":"N Reich","year":"2022","unstructured":"Reich N, H\u00f6lscher C (2022) The neuroprotective effects of glucagon-like peptide 1 in Alzheimer\u2019s and Parkinson\u2019s disease: An in-depth review. Front Neurosci 16:970925","journal-title":"Front Neurosci"},{"issue":"12","key":"1839_CR77","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.3390\/cells9122642","volume":"9","author":"N Ruffini","year":"2020","unstructured":"Ruffini N, Klingenberg S, Schweiger S, Gerber S (2020) Common factors in neurodegeneration: a meta-study revealing shared patterns on a multi-omics scale. Cells 9(12):2642","journal-title":"Cells"},{"key":"1839_CR78","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.3390\/nu15163585","volume":"15","author":"VA Ruiz-Pozo","year":"2023","unstructured":"Ruiz-Pozo VA, Tamayo-Trujillo R, Cadena-Ullauri S, Frias-Toral E, Guevara-Ram\u00edrez P, Paz-Cruz E et al (2023) The Molecular mechanisms of the relationship between insulin resistance and Parkinson\u2019s disease pathogenesis. Nutrients 15:3585","journal-title":"Nutrients"},{"issue":"8","key":"1839_CR79","doi-asserted-by":"publisher","first-page":"e14897","DOI":"10.1111\/cns.14897","volume":"30","author":"F Sayehmiri","year":"2024","unstructured":"Sayehmiri F, Motamedi F, Batool Z, Naderi N, Shaerzadeh F, Zoghi A et al (2024) Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer\u2019s disease. CNS Neurosci Ther 30(8):e14897","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"1839_CR80","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrn3156","volume":"13","author":"Z-H Sheng","year":"2012","unstructured":"Sheng Z-H, Cai Q (2012) Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci 13(2):77\u201393","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"1839_CR81","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1590\/S1516-31802006000300014","volume":"124","author":"MC Shih","year":"2006","unstructured":"Shih MC, Hoexter MQ, Andrade LAFde, Bressan RA (2006) Parkinson\u2019s disease and dopamine transporter neuroimaging: a critical review. Sao Paulo Med J 124(3):168\u2013175","journal-title":"Sao Paulo Med J"},{"issue":"2","key":"1839_CR82","first-page":"143","volume":"4","author":"S Shokouhi","year":"2014","unstructured":"Shokouhi S, Claassen D, Riddle W (2014) Imaging brain metabolism and pathology in Alzheimer\u2019s disease with positron emission tomography. J Alzheimer\u2019s Dis Park. 4(2):143","journal-title":"J Alzheimer\u2019s Dis Park."},{"issue":"5","key":"1839_CR83","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1002\/hbm.25304","volume":"42","author":"P Sojka","year":"2021","unstructured":"Sojka P, Diez I, Bare\u0161 M, Perez DL (2021) Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: a DTI study. Hum Brain Mapp 42(5):1434\u20131445","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"1839_CR84","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1111\/dom.70400","volume":"28","author":"R Spezani","year":"2026","unstructured":"Spezani R, Mandarim-de-Lacerda CA (2026) Beyond diabetes and obesity: GLP-1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation. Diabetes Obes Metab 28(3):1622\u20131637","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"1839_CR85","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2217\/nmt.13.73","volume":"4","author":"K Talbot","year":"2014","unstructured":"Talbot K (2014) Brain insulin resistance in Alzheimer\u2019s disease and its potential treatment with GLP-1 analogs. Neurodegener Dis Manag 4(1):31\u201340","journal-title":"Neurodegener Dis Manag"},{"issue":"5","key":"1839_CR86","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/ph18050614","volume":"18","author":"M Urkon","year":"2025","unstructured":"Urkon M, Ferencz E, Sz\u00e1sz JA, Szabo MIM, Orb\u00e1n-Kis K, Szatm\u00e1ri S et al (2025) Antidiabetic GLP-1 receptor agonists have neuroprotective properties in experimental animal models of Alzheimer\u2019s disease. Pharmaceuticals (Basel) 18(5):614","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"1839_CR87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","volume":"11","author":"M Verma","year":"2022","unstructured":"Verma M, Lizama BN, Chu CT (2022) Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration. Transl Neurodegener 11(1):3","journal-title":"Transl Neurodegener"},{"issue":"3","key":"1839_CR88","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.gendis.2016.05.001","volume":"3","author":"J Wang","year":"2016","unstructured":"Wang J, Chen G-J (2016) Mitochondria as a therapeutic target in Alzheimer\u2019s disease. Genes Dis 3(3):220\u2013227","journal-title":"Genes Dis"},{"issue":"1","key":"1839_CR89","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Zhao F, Ma X, Perry G, Zhu X (2020) Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances. Mol Neurodegener 15(1):30","journal-title":"Mol Neurodegener"},{"key":"1839_CR90","doi-asserted-by":"publisher","first-page":"109716","DOI":"10.1016\/j.neuropharm.2023.109716","volume":"240","author":"Z-J Wang","year":"2023","unstructured":"Wang Z-J, Li X-R, Chai S-F, Li W-R, Li S, Hou M et al (2023) Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer\u2019s disease via the GLP-1R\/SIRT1\/GLUT4 pathway. Neuropharmacology 240:109716","journal-title":"Neuropharmacology"},{"key":"1839_CR91","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhou L, Wang N, Qiu B, Yao D, Yu J et al (2025) Comprehensive characterization of metabolic consumption and production by the human brain. Neuron [Internet] 113(11):1708\u20131722.e5. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627325001758","DOI":"10.1016\/j.neuron.2025.03.003"},{"issue":"1","key":"1839_CR92","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3233\/ADR-240104","volume":"8","author":"M Xiong","year":"2024","unstructured":"Xiong M, You H, Liao W, Mai Y, Luo X, Liu Y et al (2024) The association between brain metabolic biomarkers using (18)F-FDG and cognition and vascular risk factors, as well as its usefulness in the diagnosis and staging of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis Reports 8(1):1229\u20131240","journal-title":"J Alzheimer\u2019s Dis Reports"},{"key":"1839_CR93","doi-asserted-by":"publisher","unstructured":"YangH-M (2025) Mitochondrial dysfunction in neurodegenerative diseases. Cells 14. https:\/\/doi.org\/10.3390\/cells14040276","DOI":"10.3390\/cells14040276"},{"issue":"8","key":"1839_CR94","doi-asserted-by":"publisher","first-page":"37180","DOI":"10.31083\/RCM37180","volume":"26","author":"X Yang","year":"2025","unstructured":"Yang X, Li X (2025) Research progress on the association between GLP-1 receptor agonists and cardiomyopathy. Rev Cardiovasc Med 26(8):37180","journal-title":"Rev Cardiovasc Med"},{"issue":"8","key":"1839_CR95","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/1873-3468.14077","volume":"595","author":"NMB Yapa","year":"2021","unstructured":"Yapa NMB, Lisnyak V, Reljic B, Ryan MT (2021) Mitochondrial dynamics in health and disease. FEBS Lett 595(8):1184\u20131204","journal-title":"FEBS Lett"},{"issue":"2","key":"1839_CR96","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1364\/BOE.4.000307","volume":"4","author":"MA Yaseen","year":"2013","unstructured":"Yaseen MA, Sakad\u017ei\u0107 S, Wu W, Becker W, Kasischke KA, Boas DA (2013) In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express 4(2):307\u2013321","journal-title":"Biomed Opt Express"},{"key":"1839_CR97","doi-asserted-by":"crossref","unstructured":"Zachos KA, Choi J, Godin O, Chernega T, Kwak HA, Jung JH et al (2024) Mitochondrial biomarkers and metabolic syndrome in bipolar disorder. Psychiatry Res [Internet] 339:116063. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165178124003482","DOI":"10.1016\/j.psychres.2024.116063"},{"issue":"s1","key":"1839_CR98","doi-asserted-by":"publisher","first-page":"S271","DOI":"10.3233\/JAD-179926","volume":"64","author":"H Zetterberg","year":"2018","unstructured":"Zetterberg H, Blennow K (2018) From cerebrospinal fluid to blood: the third wave of fluid biomarkers for Alzheimer\u2019s disease. J Alzheimers Dis 64(s1):S271\u2013S279","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1839_CR99","doi-asserted-by":"publisher","first-page":"525","DOI":"10.18632\/aging.202162","volume":"13","author":"H Zhang","year":"2020","unstructured":"Zhang H, Chu Y, Zheng H, Wang J, Song B, Sun Y (2020) Liraglutide improved the cognitive function of diabetic mice via the receptor of advanced glycation end products down-regulation. Aging (Albany NY) 13(1):525\u2013536","journal-title":"Aging (Albany NY)"},{"key":"1839_CR100","doi-asserted-by":"publisher","first-page":"111529","DOI":"10.1016\/j.mce.2021.111529","volume":"542","author":"M Zhang","year":"2022","unstructured":"Zhang M, Wu Y, Gao R, Chen X, Chen R, Chen Z (2022) Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer\u2019s disease by suppressing NLRP2 activation in astrocytes. Mol Cell Endocrinol 542:111529","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"1839_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4093\/dmj.2023.0115","volume":"48","author":"B Zhang","year":"2024","unstructured":"Zhang B, Chang JY, Lee MH, Ju S-H, Yi H-S, Shong M (2024) Mitochondrial stress and mitokines: therapeutic perspectives for the treatment of metabolic diseases. Diabetes Metab J 48(1):1\u201318. https:\/\/doi.org\/10.4093\/dmj.2023.0115","journal-title":"Diabetes Metab J"},{"key":"1839_CR102","doi-asserted-by":"publisher","first-page":"101180","DOI":"10.1016\/j.molmet.2021.101180","volume":"47","author":"J Zheng","year":"2021","unstructured":"Zheng J, Xie Y, Ren L, Qi L, Wu L, Pan X et al (2021) GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer\u2019s disease. Mol Metab 47:101180","journal-title":"Mol Metab"},{"issue":"1","key":"1839_CR103","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","volume":"9","author":"Z Zheng","year":"2024","unstructured":"Zheng Z, Zong Y, Ma Y, Tian Y, Pang Y, Zhang C et al (2024) Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduct Target Ther 9(1):234. https:\/\/doi.org\/10.1038\/s41392-024-01931-z","journal-title":"Signal Transduct Target Ther"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01839-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01839-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01839-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:05:59Z","timestamp":1775034359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01839-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1839"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01839-3","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}