{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:16:43Z","timestamp":1788812203238,"version":"build-2803163510"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01850-8","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:44:03Z","timestamp":1776930243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The multifaceted role of mitochondrial dysfunction in Alzheimer\u2019s disease pathogenesis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0991-7752","authenticated-orcid":false,"given":"Rasoul","family":"Ebrahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-0329","authenticated-orcid":false,"given":"Ida","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-5922","authenticated-orcid":false,"given":"Kiana","family":"Ghafourian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-4103","authenticated-orcid":false,"given":"Shahryar","family":"Rajai Firouzabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5865-2970","authenticated-orcid":false,"given":"Mobina","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-8978","authenticated-orcid":false,"given":"Samin","family":"Davoody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7432-6480","authenticated-orcid":false,"given":"Ghazal","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-9285","authenticated-orcid":false,"given":"Khadijeh","family":"Esmaeilpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"1850_CR2","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1021\/acschemneuro.2c00005","volume":"13","author":"IM Abdallah","year":"2022","unstructured":"Abdallah IM, Al-Shami KM, Yang E, Wang J, Guillaume C, Kaddoumi A (2022) Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer\u2019s Disease Mouse Model. ACS Chem Neurosci 13:1002\u20131013. https:\/\/doi.org\/10.1021\/acschemneuro.2c00005","journal-title":"ACS Chem Neurosci"},{"key":"1850_CR68","doi-asserted-by":"publisher","unstructured":"Adav SS, Park JE, Sze SK (2019) Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease. Mol Brain 12(1):8. https:\/\/doi.org\/10.1186\/s13041-019-0430-y","DOI":"10.1186\/s13041-019-0430-y"},{"key":"1850_CR3","doi-asserted-by":"publisher","unstructured":"Alemany-Cosme E, S\u00e1ez-Gonz\u00e1lez E, Moret I, Mateos B, Iborra M, Nos P, Sandoval J, Beltr\u00e1n B (2021) Oxidative stress in the pathogenesis of Crohn\u2019s disease and the interconnection with immunological response, microbiota, external environmental factors, and epigenetics. Antioxid (Basel) 10. https:\/\/doi.org\/10.3390\/antiox10010064","DOI":"10.3390\/antiox10010064"},{"key":"1850_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.apsb.2021.06.014","volume":"12","author":"SN Austad","year":"2022","unstructured":"Austad SN, Ballinger S, Buford TW, Carter CS, Smith DL Jr., Darley-Usmar V, Zhang J (2022) Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer\u2019s disease. Acta Pharm Sin B 12:511\u2013531. https:\/\/doi.org\/10.1016\/j.apsb.2021.06.014","journal-title":"Acta Pharm Sin B"},{"key":"1850_CR5","doi-asserted-by":"publisher","first-page":"11483","DOI":"10.1038\/ncomms11483","volume":"7","author":"SJ Beck","year":"2016","unstructured":"Beck SJ, Guo L, Phensy A, Tian J, Wang L, Tandon N, Gauba E, Lu L, Pascual JM, Kroener S, Du H (2016) Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer\u2019s disease. Nat Commun 7:11483. https:\/\/doi.org\/10.1038\/ncomms11483","journal-title":"Nat Commun"},{"key":"1850_CR91","doi-asserted-by":"publisher","unstructured":"Bernardi P, Gerle C, Halestrap AP, Jonas EA, Karch J, Mnatsakanyan N, et al. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions. Cell Death Differ. 2023;30(8):1869\u201385. https:\/\/doi.org\/10.1038\/s41418-023-01187-0","DOI":"10.1038\/s41418-023-01187-0"},{"key":"1850_CR6","doi-asserted-by":"publisher","first-page":"834502","DOI":"10.1155\/2014\/834502","volume":"2014","author":"H Bo","year":"2014","unstructured":"Bo H, Kang W, Jiang N, Wang X, Zhang Y, Ji LL (2014) Exercise-induced neuroprotection of hippocampus in APP\/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase. Oxid Med Cell Longev 2014:834502. https:\/\/doi.org\/10.1155\/2014\/834502","journal-title":"Oxid Med Cell Longev"},{"key":"1850_CR87","doi-asserted-by":"publisher","unstructured":"Bola\u00f1os JP, Almeida A, Moncada S (2010) Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci 35(3):145\u2013149. https:\/\/doi.org\/10.1016\/j.tibs.2009.10.006","DOI":"10.1016\/j.tibs.2009.10.006"},{"key":"1850_CR7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/s0197-4580(01)00314-1","volume":"23","author":"F Bosetti","year":"2002","unstructured":"Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, Solaini G (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer\u2019s disease. Neurobiol Aging 23:371\u2013376. https:\/\/doi.org\/10.1016\/s0197-4580(01)00314-1","journal-title":"Neurobiol Aging"},{"key":"1850_CR8","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.trci.2019.09.010","volume":"5","author":"DK Burns","year":"2019","unstructured":"Burns DK, Chiang C, Welsh-Bohmer KA, Brannan SK, Culp M, O\u2019Neil J, Runyan G, Harrigan P, Plassman BL, Lutz M, Lai E, Haneline S, Yarnall D, Yarbrough D, Metz C, Ponduru S, Sundseth S, Saunders AM (2019) The TOMMORROW study: Design of an Alzheimer\u2019s disease delay-of-onset clinical trial. Alzheimers Dement (N Y) 5:661\u2013670. https:\/\/doi.org\/10.1016\/j.trci.2019.09.010","journal-title":"Alzheimers Dement (N Y)"},{"key":"1850_CR9","doi-asserted-by":"publisher","first-page":"2105607","DOI":"10.1155\/2019\/2105607","volume":"2019","author":"G Cenini","year":"2019","unstructured":"Cenini G, Lloret A, Cascella R (2019) Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxid Med Cell Longev 2019:2105607. https:\/\/doi.org\/10.1155\/2019\/2105607","journal-title":"Oxid Med Cell Longev"},{"key":"1850_CR10","doi-asserted-by":"publisher","unstructured":"Cheng YJ, Lin CH, Lane HY (2021) Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer\u2019s disease. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22052283","DOI":"10.3390\/ijms22052283"},{"key":"1850_CR79","doi-asserted-by":"publisher","unstructured":"Chen Y, Han S, Huang X, Ni J, He X (2016a) The protective effect of icariin on mitochondrial transport and distribution in primary hippocampal neurons from 3\u00d7 Tg-AD mice. Int J Mol Sci 17(2):163. https:\/\/doi.org\/10.3390\/ijms17020163","DOI":"10.3390\/ijms17020163"},{"key":"1850_CR71","doi-asserted-by":"publisher","unstructured":"Chen Y, Liu C, Parker WD, Chen H, Beach TG, Liu X et al (2016b) Mitochondrial DNA rearrangement spectrum in brain tissue of Alzheimer's disease: analysis of 13 cases. PLoS One 11(6):e0154582. https:\/\/doi.org\/10.1371\/journal.pone.0154582","DOI":"10.1371\/journal.pone.0154582"},{"key":"1850_CR11","doi-asserted-by":"publisher","first-page":"104556","DOI":"10.1016\/j.neubiorev.2022.104556","volume":"135","author":"CQ Chu","year":"2022","unstructured":"Chu CQ, Yu LL, Qi GY, Mi YS, Wu WQ, Lee YK, Zhai QX, Tian FW, Chen W (2022) Can dietary patterns prevent cognitive impairment and reduce Alzheimer\u2019s disease risk: Exploring the underlying mechanisms of effects. Neurosci Biobehav Rev 135:104556. https:\/\/doi.org\/10.1016\/j.neubiorev.2022.104556","journal-title":"Neurosci Biobehav Rev"},{"key":"1850_CR12","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","volume":"19","author":"SC Cunnane","year":"2020","unstructured":"Cunnane SC et al (2020) Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov 19:609\u2013633. https:\/\/doi.org\/10.1038\/s41573-020-0072-x","journal-title":"Nat Rev Drug Discov"},{"key":"1850_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41583-022-00558-9","volume":"23","author":"FG De Felice","year":"2022","unstructured":"De Felice FG, Gon\u00e7alves RA, Ferreira ST (2022) Impaired insulin signalling and allostatic load in Alzheimer disease. Nat Rev Neurosci 23:215\u2013230. https:\/\/doi.org\/10.1038\/s41583-022-00558-9","journal-title":"Nat Rev Neurosci"},{"key":"1850_CR77","doi-asserted-by":"publisher","unstructured":"Dhapola R, Sarma P, Medhi B, Prakash A, Reddy DH (2022) Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease. Mol Neurobiol 59(1):535\u2013555. https:\/\/doi.org\/10.1007\/s12035-021-02612-6","DOI":"10.1007\/s12035-021-02612-6"},{"key":"1850_CR14","first-page":"1835","volume":"57","author":"Y Eguchi","year":"1997","unstructured":"Eguchi Y, Shimizu S, Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57:1835\u20131840","journal-title":"Cancer Res"},{"key":"1850_CR15","doi-asserted-by":"publisher","first-page":"1155630","DOI":"10.3389\/fnagi.2023.1155630","volume":"15","author":"SJ Ephrame","year":"2023","unstructured":"Ephrame SJ, Cork GK, Marshall V, Johnston MA, Shawa J, Alghusen I, Qiang A, Denson AR, Carman MS, Fedosyuk H, Swerdlow RH, Slawson C (2023) O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer\u2019s disease. Front Aging Neurosci 15:1155630. https:\/\/doi.org\/10.3389\/fnagi.2023.1155630","journal-title":"Front Aging Neurosci"},{"key":"1850_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","volume":"24","author":"EF Fang","year":"2016","unstructured":"Fang EF et al (2016) NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab 24:566\u2013581. https:\/\/doi.org\/10.1016\/j.cmet.2016.09.004","journal-title":"Cell Metab"},{"key":"1850_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0197-4580(80)90005-6","volume":"1","author":"SH Ferris","year":"1980","unstructured":"Ferris SH, de Leon MJ, Wolf AP, Farkas T, Christman DR, Reisberg B, Fowler JS, MacGregor R, Goldman A, George AE, Rampal S (1980) Positron Emission Tomography in the Study of Aging and Senile Dementia. Neurobiol Aging 1:127\u2013131. https:\/\/doi.org\/10.1016\/0197-4580(80)90005-6","journal-title":"Neurobiol Aging"},{"key":"1850_CR65","doi-asserted-by":"publisher","unstructured":"Gibson GE, Shi Q (2010) A mitocentric view of Alzheimer\u2019s disease suggests multi-faceted treatments. J Alzheimers Dis 20(Suppl 2):S591\u2013S607. https:\/\/doi.org\/10.3233\/jad-2010-100336","DOI":"10.3233\/jad-2010-100336"},{"key":"1850_CR18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1079\/pns2002146","volume":"61","author":"M Grundman","year":"2002","unstructured":"Grundman M, Grundman M, Delaney P (2002) Antioxidant strategies for Alzheimer\u2019s disease. Proc Nutr Soc 61:191\u2013202. https:\/\/doi.org\/10.1079\/pns2002146","journal-title":"Proc Nutr Soc"},{"key":"1850_CR19","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3233\/jad-160702","volume":"57","author":"L Guo","year":"2017","unstructured":"Guo L, Tian J, Du H (2017) Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer\u2019s Disease. J Alzheimers Dis 57:1071\u20131086. https:\/\/doi.org\/10.3233\/jad-160702","journal-title":"J Alzheimers Dis"},{"key":"1850_CR20","doi-asserted-by":"publisher","first-page":"112752","DOI":"10.1016\/j.fct.2021.112752","volume":"159","author":"F Hadrich","year":"2022","unstructured":"Hadrich F, Chamkha M, Sayadi S (2022) Protective effect of olive leaves phenolic compounds against neurodegenerative disorders: Promising alternative for Alzheimer and Parkinson diseases modulation. Food Chem Toxicol 159:112752. https:\/\/doi.org\/10.1016\/j.fct.2021.112752","journal-title":"Food Chem Toxicol"},{"key":"1850_CR74","doi-asserted-by":"publisher","unstructured":"Halestrap, A.P. (2009). What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 46(6):821\u2013831. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.02.021","DOI":"10.1016\/j.yjmcc.2009.02.021"},{"key":"1850_CR21","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s42003-020-1079-x","volume":"3","author":"TC Hammond","year":"2020","unstructured":"Hammond TC, Xing X, Wang C, Ma D, Nho K, Crane PK, Elahi F, Ziegler DA, Liang G, Cheng Q, Yanckello LM, Jacobs N, Lin AL (2020) \u03b2-amyloid and tau drive early Alzheimer\u2019s disease decline while glucose hypometabolism drives late decline. Commun Biol 3:352. https:\/\/doi.org\/10.1038\/s42003-020-1079-x","journal-title":"Commun Biol"},{"key":"1850_CR90","doi-asserted-by":"crossref","unstructured":"Hansson MJ, Persson T, Friberg H, Keep MF, Rees A, Wieloch T, et al. (2003) Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria. Brain Res 960(1\u20132):99\u2013111","DOI":"10.1016\/S0006-8993(02)03798-8"},{"key":"1850_CR81","doi-asserted-by":"publisher","unstructured":"Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, et al. (2008) The amyloid $\\beta$-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci USA 105(35):13145\u201313150. https:\/\/doi.org\/10.1073\/pnas.0806192105","DOI":"10.1073\/pnas.0806192105"},{"key":"1850_CR22","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1080\/10717544.2020.1745328","volume":"27","author":"Y Han","year":"2020","unstructured":"Han Y, Chu X, Cui L, Fu S, Gao C, Li Y, Sun B (2020) Neuronal mitochondria-targeted therapy for Alzheimer\u2019s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems. Drug Deliv 27:502\u2013518. https:\/\/doi.org\/10.1080\/10717544.2020.1745328","journal-title":"Drug Deliv"},{"key":"1850_CR23","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"CR Jack Jr","year":"2024","unstructured":"Jack CR Jr., Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC (2024) Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup. Alzheimers Dement 20:5143\u20135169. https:\/\/doi.org\/10.1002\/alz.13859","journal-title":"Alzheimers Dement"},{"key":"1850_CR24","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1093\/nar\/gks1227","volume":"41","author":"N Jin","year":"2013","unstructured":"Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F (2013) CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer\u2019s disease. Nucleic Acids Res 41:3240\u20133256. https:\/\/doi.org\/10.1093\/nar\/gks1227","journal-title":"Nucleic Acids Res"},{"key":"1850_CR25","doi-asserted-by":"crossref","unstructured":"Jurcau A (2021) Insights into the pathogenesis of neurodegenerative diseases: focus on mitochondrial dysfunction and oxidative stress. Int J Mol Sci","DOI":"10.3390\/ijms222111847"},{"key":"1850_CR83","doi-asserted-by":"publisher","unstructured":"Leuner K, Sch\u00fctt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, et al. (2012) Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 16(12):1421\u20131433. https:\/\/doi.org\/10.1089\/ars.2011.4173","DOI":"10.1089\/ars.2011.4173"},{"key":"1850_CR67","doi-asserted-by":"publisher","unstructured":"Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, et al. (2008) Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci USA. 105(11):4441\u201344416. https:\/\/doi.org\/10.1073\/pnas.0709259105","DOI":"10.1073\/pnas.0709259105"},{"key":"1850_CR86","doi-asserted-by":"publisher","unstructured":"Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, et al. (2010) A\u03b2 and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10(8):1621\u201333. https:\/\/doi.org\/10.1002\/pmic.200900651","DOI":"10.1002\/pmic.200900651"},{"key":"1850_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1080\/713803492","volume":"48","author":"SI Liochev","year":"1999","unstructured":"Liochev SI, Fridovich I (1999) Superoxide and iron: partners in crime. IUBMB Life 48:157\u2013161. https:\/\/doi.org\/10.1080\/713803492","journal-title":"IUBMB Life"},{"key":"1850_CR26","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1111\/j.1742-4658.2005.04833.x","volume":"272","author":"X Li","year":"2005","unstructured":"Li X, Alafuzoff I, Soininen H, Winblad B, Pei JJ (2005) Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer\u2019s disease brain. Febs j 272:4211\u20134220. https:\/\/doi.org\/10.1111\/j.1742-4658.2005.04833.x","journal-title":"Febs j"},{"key":"1850_CR27","doi-asserted-by":"publisher","first-page":"110887","DOI":"10.1016\/j.biopha.2020.110887","volume":"132","author":"Y Li","year":"2020","unstructured":"Li Y, Zhang J, Wan J, Liu A, Sun J (2020) Melatonin regulates A\u03b2 production\/clearance balance and A\u03b2 neurotoxicity: A potential therapeutic molecule for Alzheimer\u2019s disease. Biomed Pharmacother 132:110887. https:\/\/doi.org\/10.1016\/j.biopha.2020.110887","journal-title":"Biomed Pharmacother"},{"key":"1850_CR76","doi-asserted-by":"publisher","unstructured":"Ma K, Chen G, Li W, Kepp O, Zhu Y, Chen Q (2020) Mitophagy, mitochondrial homeostasis, and cell fate. Front Cell Dev Biol 8:467. https:\/\/doi.org\/10.3389\/fcell.2020.00467","DOI":"10.3389\/fcell.2020.00467"},{"key":"1850_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1021\/pr500813f","volume":"14","author":"RH Malty","year":"2015","unstructured":"Malty RH, Jessulat M, Jin K, Musso G, Vlasblom J, Phanse S, Zhang Z, Babu M (2015) Mitochondrial targets for pharmacological intervention in human disease. J Proteome Res 14:5\u201321. https:\/\/doi.org\/10.1021\/pr500813f","journal-title":"J Proteome Res"},{"key":"1850_CR30","doi-asserted-by":"publisher","first-page":"119985","DOI":"10.1016\/j.lfs.2021.119985","volume":"285","author":"S Mani","year":"2021","unstructured":"Mani S, Swargiary G, Singh M, Agarwal S, Dey A, Ojha S, Jha NK (2021) Mitochondrial defects: An emerging theranostic avenue towards Alzheimer\u2019s associated dysregulations. Life Sci 285:119985. https:\/\/doi.org\/10.1016\/j.lfs.2021.119985","journal-title":"Life Sci"},{"key":"1850_CR31","doi-asserted-by":"publisher","unstructured":"MoawadM, Serag I, Alkhawaldeh IM, Abbas A, Sharaf A, Alsalah S, Sadeq MA, Shalaby MMM, Hefnawy MT, Abouzid M, Meshref M (2024) Exploring the mechanisms and therapeutic approaches of mitochondrial dysfunction in Alzheimer\u2019s disease: an educational literature review. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-024-04468-y","DOI":"10.1007\/s12035-024-04468-y"},{"key":"1850_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20081386","volume":"417","author":"MP Murphy","year":"2009","unstructured":"Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417:1\u201313. https:\/\/doi.org\/10.1042\/bj20081386","journal-title":"Biochem J"},{"key":"1850_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s41824-021-00123-0","volume":"6","author":"A Myoraku","year":"2022","unstructured":"Myoraku A, Klein G, Landau S, Tosun D (2022) Regional uptakes from early-frame amyloid PET and (18)F-FDG PET scans are comparable independent of disease state. Eur J Hybrid Imaging 6:2. https:\/\/doi.org\/10.1186\/s41824-021-00123-0","journal-title":"Eur J Hybrid Imaging"},{"key":"1850_CR88","doi-asserted-by":"publisher","unstructured":"Newington JT, Pitts A, Chien A, Arseneault R, Schubert D, Cumming RC (2011) Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect. PLoS ONE 6(4):e19191. https:\/\/doi.org\/10.1371\/journal.pone.0019191","DOI":"10.1371\/journal.pone.0019191"},{"key":"1850_CR34","doi-asserted-by":"publisher","first-page":"111623","DOI":"10.1016\/j.biopha.2021.111623","volume":"139","author":"TT Nguyen","year":"2021","unstructured":"Nguyen TT, Nguyen TTD, Nguyen TKO, Vo TK, Vo VG (2021) Advances in developing therapeutic strategies for Alzheimer\u2019s disease. Biomed Pharmacother 139:111623. https:\/\/doi.org\/10.1016\/j.biopha.2021.111623","journal-title":"Biomed Pharmacother"},{"key":"1850_CR35","doi-asserted-by":"publisher","first-page":"753","DOI":"10.2174\/1567205018666211208125855","volume":"18","author":"IG Onyango","year":"2021","unstructured":"Onyango IG, Bennett JP, Stokin GB (2021) Mitochondrially-Targeted Therapeutic Strategies for Alzheimer\u2019s Disease. Curr Alzheimer Res 18:753\u2013771. https:\/\/doi.org\/10.2174\/1567205018666211208125855","journal-title":"Curr Alzheimer Res"},{"key":"1850_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13195-019-0512-1","volume":"11","author":"YN Ou","year":"2019","unstructured":"Ou YN, Xu W, Li JQ, Guo Y, Cui M, Chen KL, Huang YY, Dong Q, Tan L, Yu JT (2019) FDG-PET as an independent biomarker for Alzheimer\u2019s biological diagnosis: a longitudinal study. Alzheimers Res Ther 11:57. https:\/\/doi.org\/10.1186\/s13195-019-0512-1","journal-title":"Alzheimers Res Ther"},{"key":"1850_CR80","doi-asserted-by":"publisher","unstructured":"Panchal K, Tiwari AK (2020) Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, A\u03b242 and Appl) in Drosophila melanogaster. Biol Open 9(9):bio049569. https:\/\/doi.org\/10.1242\/bio.049569","DOI":"10.1242\/bio.049569"},{"key":"1850_CR37","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1212\/wnl.44.6.1090","volume":"44","author":"WD Parker Jr","year":"1994","unstructured":"Parker WD Jr., Parks J, Filley CM, Kleinschmidt-DeMasters BK (1994) Electron transport chain defects in Alzheimer\u2019s disease brain. Neurology 44:1090\u20131096. https:\/\/doi.org\/10.1212\/wnl.44.6.1090","journal-title":"Neurology"},{"key":"1850_CR75","doi-asserted-by":"publisher","unstructured":"Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, et al (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. Embo J 36:3356\u20133371. https:\/\/doi.org\/10.15252\/embj.201796797","DOI":"10.15252\/embj.201796797"},{"key":"1850_CR70","doi-asserted-by":"publisher","unstructured":"Perez Ortiz JM, Swerdlow RH (2019) Mitochondrial dysfunction in Alzheimer\u2019s disease: role in pathogenesis and novel therapeutic opportunities. Br J Pharmacol 176(18):3489\u20133507. https:\/\/doi.org\/10.1111\/bph.14585","DOI":"10.1111\/bph.14585"},{"key":"1850_CR38","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.neuropharm.2019.01.030","volume":"148","author":"K Pierzynowska","year":"2019","unstructured":"Pierzynowska K, Podlacha M, Gaffke L, Majkutewicz I, Mantej J, W\u0119grzyn A, Osiad\u0142y M, My\u015bli\u0144ska D, W\u0119grzyn G (2019) Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer\u2019s disease. Neuropharmacology 148:332\u2013346. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.01.030","journal-title":"Neuropharmacology"},{"key":"1850_CR39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth HW, LaFerla FM (2010) Alzheimer\u2019s disease. N Engl J Med 362:329\u2013344. https:\/\/doi.org\/10.1056\/NEJMra0909142","journal-title":"N Engl J Med"},{"key":"1850_CR40","doi-asserted-by":"publisher","unstructured":"Rahman MA, Rahman MS, Rahman MDH, Rasheduzzaman M, Mamun-Or-Rashid A, Uddin MJ, Rahman MR, Hwang H, Pang MG, Rhim H (2020) Modulatory effects of autophagy on APP processing as a potential treatment target for Alzheimer\u2019s disease. Biomedicines 9. https:\/\/doi.org\/10.3390\/biomedicines9010005","DOI":"10.3390\/biomedicines9010005"},{"key":"1850_CR89","doi-asserted-by":"publisher","unstructured":"Rao VK, Carlson EA, Yan SS (2014) Mitochondrial permeability transition pore is a potential drug target for neurodegeneration. Biochim Biophys Acta 1842(8):1267\u20131272. https:\/\/doi.org\/10.1016\/j.bbadis.2013.09.003","DOI":"10.1016\/j.bbadis.2013.09.003"},{"key":"1850_CR41","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1136\/jim-2016-000240","volume":"64","author":"PH Reddy","year":"2016","unstructured":"Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Kandimalla R, Kuruva CS (2016) Protective effects of a natural product, curcumin, against amyloid \u03b2 induced mitochondrial and synaptic toxicities in Alzheimer\u2019s disease. J Investig Med 64:1220\u20131234. https:\/\/doi.org\/10.1136\/jim-2016-000240","journal-title":"J Investig Med"},{"key":"1850_CR42","doi-asserted-by":"publisher","first-page":"e36470","DOI":"10.1016\/j.heliyon.2024.e36470","volume":"10","author":"J Ren","year":"2024","unstructured":"Ren J, Xiang B, Xueling L, Han X, Yang Z, Zhang M, Zhang Y (2024) Molecular mechanisms of mitochondrial homeostasis regulation in neurons and possible therapeutic approaches for Alzheimer\u2019s disease. Heliyon 10:e36470. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e36470","journal-title":"Heliyon"},{"key":"1850_CR85","doi-asserted-by":"publisher","unstructured":"Rhein V, Baysang G, Rao S, Meier F, Bonert A, M\u00fcller-Spahn F, et al (2009a) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29(6)1063\u20131071. https:\/\/doi.org\/10.1007\/s10571-009-9398-y","DOI":"10.1007\/s10571-009-9398-y"},{"key":"1850_CR92","doi-asserted-by":"publisher","unstructured":"Rhein V, Song X, Wiesner A, et al. (2009b) Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci USA 106(47):20057\u201320062. https:\/\/doi.org\/10.1073\/pnas.0905529106","DOI":"10.1073\/pnas.0905529106"},{"key":"1850_CR43","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.neurol.2019.08.005","volume":"175","author":"GC Rom\u00e1n","year":"2019","unstructured":"Rom\u00e1n GC, Jackson RE, Gadhia R, Rom\u00e1n AN, Reis J (2019) Mediterranean diet: The role of long-chain \u03c9-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol 175:724\u2013741. https:\/\/doi.org\/10.1016\/j.neurol.2019.08.005","journal-title":"Rev Neurol"},{"key":"1850_CR44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13195-018-0354-2","volume":"10","author":"S Sang","year":"2018","unstructured":"Sang S, Pan X, Chen Z, Zeng F, Pan S, Liu H, Jin L, Fei G, Wang C, Ren S, Jiao F, Bao W, Zhou W, Guan Y, Zhang Y, Shi H, Wang Y, Yu X, Wang Y, Zhong C (2018) Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer\u2019s disease, whereas amyloid deposition does not. Alzheimers Res Ther 10:26. https:\/\/doi.org\/10.1186\/s13195-018-0354-2","journal-title":"Alzheimers Res Ther"},{"key":"1850_CR45","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.bcp.2009.06.021","volume":"78","author":"H Schaffhauser","year":"2009","unstructured":"Schaffhauser H, Mathiasen JR, Dicamillo A, Huffman MJ, Lu LD, McKenna BA, Qian J, Marino MJ (2009) Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. Biochem Pharmacol 78:1035\u20131042. https:\/\/doi.org\/10.1016\/j.bcp.2009.06.021","journal-title":"Biochem Pharmacol"},{"key":"1850_CR46","doi-asserted-by":"publisher","first-page":"10771","DOI":"10.1073\/pnas.91.23.10771","volume":"91","author":"MK Shigenaga","year":"1994","unstructured":"Shigenaga MK, Hagen TM, Ames BN (1994) Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 91:10771\u201310778. https:\/\/doi.org\/10.1073\/pnas.91.23.10771","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1850_CR47","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","volume":"25","author":"H Sies","year":"2024","unstructured":"Sies H, Mailloux RJ, Jakob U (2024) Fundamentals of redox regulation in biology. Nat Rev Mol Cell Biol 25:701\u2013719. https:\/\/doi.org\/10.1038\/s41580-024-00730-2","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1850_CR72","doi-asserted-by":"publisher","unstructured":"Soltys DT, Pereira CPM, Rowies FT, Farfel JM, Grinberg LT, Suemoto CK, et al (2019) Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects. Neurobiol Aging 73:161\u2013170. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.09.015","DOI":"10.1016\/j.neurobiolaging.2018.09.015"},{"key":"1850_CR48","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s42003-020-01584-y","volume":"4","author":"A Stojakovic","year":"2021","unstructured":"Stojakovic A et al (2021) Partial inhibition of mitochondrial complex I ameliorates Alzheimer\u2019s disease pathology and cognition in APP\/PS1 female mice. Commun Biology 4:61. https:\/\/doi.org\/10.1038\/s42003-020-01584-y","journal-title":"Commun Biology"},{"key":"1850_CR49","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3233\/jad-2011-101425","volume":"24","author":"R Sultana","year":"2011","unstructured":"Sultana R, Mecocci P, Mangialasche F, Cecchetti R, Baglioni M, Butterfield DA (2011) Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer\u2019s disease: insights into the role of oxidative stress in Alzheimer\u2019s disease and initial investigations into a potential biomarker for this dementing disorder. J Alzheimers Dis 24:77\u201384. https:\/\/doi.org\/10.3233\/jad-2011-101425","journal-title":"J Alzheimers Dis"},{"key":"1850_CR82","doi-asserted-by":"publisher","unstructured":"Supnet C, Bezprozvanny I (2010) Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease. J Alzheimers Dis 20(s2):S487\u2013S498. https:\/\/doi.org\/10.3233\/jad-2010-100306","DOI":"10.3233\/jad-2010-100306"},{"key":"1850_CR73","doi-asserted-by":"publisher","unstructured":"Swerdlow RH (2018) Mitochondria and Mitochondrial Cascades in Alzheimer\u2019s Disease. J Alzheimers Dis 62(3):1403\u20131416. https:\/\/doi.org\/10.3233\/jad-170585","DOI":"10.3233\/jad-170585"},{"issue":"Suppl 2","key":"1850_CR50","doi-asserted-by":"publisher","first-page":"S265","DOI":"10.3233\/jad-2010-100339","volume":"20","author":"RH Swerdlow","year":"2010","unstructured":"Swerdlow RH, Burns JM, Khan SM (2010) The Alzheimer\u2019s disease mitochondrial cascade hypothesis. J Alzheimers Dis 20(Suppl 2):S265\u2013279. https:\/\/doi.org\/10.3233\/jad-2010-100339","journal-title":"J Alzheimers Dis"},{"key":"1850_CR51","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","volume":"1842","author":"RH Swerdlow","year":"2014","unstructured":"Swerdlow RH, Burns JM, Khan SM (2014) The Alzheimer\u2019s disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 1842:1219\u20131231. https:\/\/doi.org\/10.1016\/j.bbadis.2013.09.010","journal-title":"Biochim Biophys Acta"},{"key":"1850_CR69","doi-asserted-by":"publisher","unstructured":"Swerdlow RH, Parks JK, Cassarino DS, Maguire DJ, Maguire RS, Bennett JP Jr et al (1997) Cybrids in Alzheimer's disease: a cellular model of the disease. Neurology 49(4):918\u2013925. https:\/\/doi.org\/10.1212\/wnl.49.4.918","DOI":"10.1212\/wnl.49.4.918"},{"key":"1850_CR52","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1111\/ene.15246","volume":"29","author":"T Terada","year":"2022","unstructured":"Terada T, Therriault J, Kang MS, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Poltronetti NM, Ottoy J, Arias JF, Bezgin G, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P (2022) Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer\u2019s disease. Eur J Neurol 29:1324\u20131334. https:\/\/doi.org\/10.1111\/ene.15246","journal-title":"Eur J Neurol"},{"key":"1850_CR53","doi-asserted-by":"publisher","first-page":"108026","DOI":"10.1016\/j.jdiacomp.2021.108026","volume":"35","author":"S Terzo","year":"2021","unstructured":"Terzo S, Amato A, Mul\u00e8 F (2021) From obesity to Alzheimer\u2019s disease through insulin resistance. J Diabetes Complications 35:108026. https:\/\/doi.org\/10.1016\/j.jdiacomp.2021.108026","journal-title":"J Diabetes Complications"},{"key":"1850_CR54","doi-asserted-by":"publisher","first-page":"6256","DOI":"10.1038\/s41467-024-50354-5","volume":"15","author":"JR Tribble","year":"2024","unstructured":"Tribble JR, J\u00f6e M, Varricchio C, Otmani A, Canovai A, Habchi B, Daskalakis E, Chaleckis R, Loreto A, Gilley J, Wheelock CE, J\u00f3hannesson G, Wong RCB, Coleman MP, Brancale A, Williams PA (2024) NMNAT2 is a druggable target to drive neuronal NAD production. Nat Commun 15:6256. https:\/\/doi.org\/10.1038\/s41467-024-50354-5","journal-title":"Nat Commun"},{"key":"1850_CR55","doi-asserted-by":"publisher","unstructured":"Vargas-Mart\u00ednez AM (2024) Economic evaluations of technology-based interventions used to provide care support for people with mild dementia or mild cognitive impairment and their caregivers: a systematic review. J Alzheimers Dis 13872877241291070. https:\/\/doi.org\/10.1177\/13872877241291070","DOI":"10.1177\/13872877241291070"},{"key":"1850_CR56","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3109\/15622975.2015.1066513","volume":"17","author":"A von Gunten","year":"2016","unstructured":"von Gunten A, Schlaefke S, \u00dcberla K (2016) Efficacy of Ginkgo biloba extract EGb 761(\u00ae) in dementia with behavioural and psychological symptoms: A systematic review. World J Biol Psychiatry 17:622\u2013633. https:\/\/doi.org\/10.3109\/15622975.2015.1066513","journal-title":"World J Biol Psychiatry"},{"key":"1850_CR57","doi-asserted-by":"publisher","first-page":"130061","DOI":"10.1016\/j.bbagen.2021.130061","volume":"1866","author":"S Wang","year":"2022","unstructured":"Wang S, Zheng J, Ma L, Petersen RB, Xu L, Huang K (2022) Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors. Biochim Biophys Acta Gen Subj 1866:130061. https:\/\/doi.org\/10.1016\/j.bbagen.2021.130061","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"1850_CR78","doi-asserted-by":"publisher","unstructured":"Wang W, Yin J, Ma X, Zhao F, Siedlak SL, Wang Z, et al (2017) Inhibition of mitochondrial fragmentation protects against Alzheimer\u2019s disease in rodent model. Hum Mol Genet 26(21):4118\u20134131. https:\/\/doi.org\/10.1093\/hmg\/ddx299","DOI":"10.1093\/hmg\/ddx299"},{"key":"1850_CR58","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Zhao F, Ma X, Perry G, Zhu X (2020) Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances. Mol Neurodegener 15:30. https:\/\/doi.org\/10.1186\/s13024-020-00376-6","journal-title":"Mol Neurodegener"},{"key":"1850_CR59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41392-024-01812-5","volume":"9","author":"X Wang","year":"2024","unstructured":"Wang X, Liu Q, Yu H-t, Xie J-z, Zhao J-n, Fang Z-t, Qu M, Zhang Y, Yang Y, Wang J-Z (2024) A positive feedback inhibition of isocitrate dehydrogenase 3\u03b2 on paired-box gene 6 promotes Alzheimer-like pathology. Signal Transduct Target Therapy 9:105. https:\/\/doi.org\/10.1038\/s41392-024-01812-5","journal-title":"Signal Transduct Target Therapy"},{"key":"1850_CR60","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.nicl.2018.07.016","volume":"20","author":"CM Weise","year":"2018","unstructured":"Weise CM, Chen K, Chen Y, Kuang X, Savage CR, Reiman EM (2018) Left lateralized cerebral glucose metabolism declines in amyloid-\u03b2 positive persons with mild cognitive impairment. Neuroimage Clin 20:286\u2013296. https:\/\/doi.org\/10.1016\/j.nicl.2018.07.016","journal-title":"Neuroimage Clin"},{"key":"1850_CR61","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3233\/jad-141890","volume":"44","author":"C Zhang","year":"2015","unstructured":"Zhang C, Rissman RA, Feng J (2015) Characterization of ATP alternations in an Alzheimer\u2019s disease transgenic mouse model. J Alzheimers Dis 44:375\u2013378. https:\/\/doi.org\/10.3233\/jad-141890","journal-title":"J Alzheimers Dis"},{"key":"1850_CR62","doi-asserted-by":"publisher","first-page":"e13054","DOI":"10.1111\/acel.13054","volume":"19","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Shen Q, Wu X, Zhang D, Xing D (2020) Activation of PKA\/SIRT1 signaling pathway by photobiomodulation therapy reduces A\u03b2 levels in Alzheimer\u2019s disease models. Aging Cell 19:e13054. https:\/\/doi.org\/10.1111\/acel.13054","journal-title":"Aging Cell"},{"key":"1850_CR63","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13195-025-01695-w","volume":"17","author":"F Zhou","year":"2025","unstructured":"Zhou F, Lian W, Yuan X, Wang Z, Xia C, Yan Y, Wang W, Tong Z, Cheng Y, Xu J, He J, Zhang W (2025) Cornuside alleviates cognitive impairments induced by A\u03b21\u2009\u2013\u200942 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy. Alzheimers Res Ther 17:47. https:\/\/doi.org\/10.1186\/s13195-025-01695-w","journal-title":"Alzheimers Res Ther"},{"key":"1850_CR64","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1080\/10408398.2016.1251390","volume":"58","author":"F Zhu","year":"2018","unstructured":"Zhu F, Du B, Xu B (2018) Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: A review. Crit Rev Food Sci Nutr 58:1260\u20131270. https:\/\/doi.org\/10.1080\/10408398.2016.1251390","journal-title":"Crit Rev Food Sci Nutr"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01850-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:44:05Z","timestamp":1776930245000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01850-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1850"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01850-8","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"16 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}