{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:55:31Z","timestamp":1781333731476,"version":"3.54.1"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82570586"],"award-info":[{"award-number":["82570586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01877-x","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:00:20Z","timestamp":1781330420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the gut-brain axis: microbial interventions for neurological disorders"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9518-6532","authenticated-orcid":false,"given":"Yu-Yao","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-2534","authenticated-orcid":false,"given":"Zhen-Ao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-5720","authenticated-orcid":false,"given":"Li-Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-5231","authenticated-orcid":false,"given":"Zi-Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"1877_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","volume":"76","author":"A Adak","year":"2019","unstructured":"Adak A, Khan MR (2019) An insight into gut microbiota and its functionalities. Cell Mol Life Sci 76:473\u2013493. https:\/\/doi.org\/10.1007\/s00018-018-2943-4","journal-title":"Cell Mol Life Sci"},{"key":"1877_CR2","doi-asserted-by":"publisher","first-page":"1173660","DOI":"10.3389\/fnut.2023.1173660","volume":"10","author":"F Ansari","year":"2023","unstructured":"Ansari F, Neshat M, Pourjafar H, Jafari SM, Samakkhah SA, Mirzakhani E (2023) The role of probiotics and prebiotics in modulating of the gut-brain axis. Front Nutr 10:1173660. https:\/\/doi.org\/10.3389\/fnut.2023.1173660","journal-title":"Front Nutr"},{"key":"1877_CR3","doi-asserted-by":"publisher","first-page":"6665","DOI":"10.1038\/s41598-021-85897-w","volume":"11","author":"SA Appiah","year":"2021","unstructured":"Appiah SA, Foxx CL, Langgartner D, Palmer A, Zambrano CA, Braumuller S, Schaefer EJ, Wachter U, Elam BL, Radermacher P, Stamper CE, Heinze JD, Salazar SN, Luthens AK, Arnold AL, Reber SO, Huber-Lang M, Lowry CA, Halbgebauer R (2021) Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock. Sci Rep 11:6665. https:\/\/doi.org\/10.1038\/s41598-021-85897-w","journal-title":"Sci Rep"},{"key":"1877_CR4","doi-asserted-by":"publisher","first-page":"118250","DOI":"10.1016\/j.ecoenv.2025.118250","volume":"297","author":"A Banerjee","year":"2025","unstructured":"Banerjee A, Mal S, Roy P, Chatterji U (2025) Regulating environmental arsenic-mediated gut-brain toxicity using chitosan-conjugated luteolin gold nanoparticles. Ecotoxicol Environ Saf 297:118250. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118250","journal-title":"Ecotoxicol Environ Saf"},{"key":"1877_CR5","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nm.4068","volume":"22","author":"C Benakis","year":"2016","unstructured":"Benakis C, Brea D, Caballero S, Faraco G, Moore J, Murphy M, Sita G, Racchumi G, Ling L, Pamer EG, Iadecola C, Anrather J (2016) Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta t cells. Nat Med 22:516\u2013523. https:\/\/doi.org\/10.1038\/nm.4068","journal-title":"Nat Med"},{"key":"1877_CR6","doi-asserted-by":"publisher","unstructured":"Bycura D, Santos AC, Shiffer A, Kyman S, Winfree K, Sutliffe J, Pearson T, Sonderegger D, Cope E, Caporaso JG (2021) Impact of different exercise modalities on the human gut microbiome. Sports (Basel) 9. https:\/\/doi.org\/10.3390\/sports9020014","DOI":"10.3390\/sports9020014"},{"key":"1877_CR7","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/ptr.8450","volume":"39","author":"Y Cai","year":"2025","unstructured":"Cai Y, Zhang X, Zhang Q, Zhou L, Huang Y, Qian H, Zhang L, Xu C, Xia L, Chen L, Ren P, Huang X (2025) Ferulic acid alleviates traumatic brain injury and gastrointestinal disorders by promoting ghrelin to regulate the microbiota-brain-gut axis inflammation and pyroptosis. Phytother Res 39:2291\u20132311. https:\/\/doi.org\/10.1002\/ptr.8450","journal-title":"Phytother Res"},{"key":"1877_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1126\/science.abc6108","volume":"374","author":"S Carloni","year":"2021","unstructured":"Carloni S, Bertocchi A, Mancinelli S, Bellini M, Erreni M, Borreca A, Braga D, Giugliano S, Mozzarelli AM, Manganaro D, Fernandez Perez D, Colombo F, Di Sabatino A, Pasini D, Penna G, Matteoli M, Lodato S, Rescigno M (2021) Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science 374:439\u2013448. https:\/\/doi.org\/10.1126\/science.abc6108","journal-title":"Science"},{"key":"1877_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neuroscience.2024.10.053","volume":"564","author":"D Chen","year":"2025","unstructured":"Chen D, Xie J, Chen X, Qin B, Kong D, Luo J (2025) Fecal microbiota transplantation alleviates neuronal apoptosis, necroptosis and reactive microglia activation after ischemic stroke. Neuroscience 564:299\u2013305. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.10.053","journal-title":"Neuroscience"},{"key":"1877_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1055\/s-0043-1760865","volume":"36","author":"YW Cheng","year":"2023","unstructured":"Cheng YW, Fischer M (2023) Fecal microbiota transplantation. Clin Colon Rectal Surg 36:151\u2013156. https:\/\/doi.org\/10.1055\/s-0043-1760865","journal-title":"Clin Colon Rectal Surg"},{"key":"1877_CR11","doi-asserted-by":"publisher","first-page":"Cd014804","DOI":"10.1002\/14651858.CD014804.pub2","volume":"9","author":"TE Cooper","year":"2022","unstructured":"Cooper TE, Scholes-Robertson N, Craig JC, Hawley CM, Howell M, Johnson DW, Teixeira-Pinto A, Jaure A, Wong G (2022) Synbiotics, prebiotics and probiotics for solid organ transplant recipients. Cochrane Database Syst Rev 9:Cd014804. https:\/\/doi.org\/10.1002\/14651858.CD014804.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"1877_CR12","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG (2012) Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701\u2013712. https:\/\/doi.org\/10.1038\/nrn3346","journal-title":"Nat Rev Neurosci"},{"key":"1877_CR13","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1007\/s11064-020-03082-3","volume":"45","author":"XL Deng","year":"2020","unstructured":"Deng XL, Feng L, Wang ZX, Zhao YE, Zhan Q, Wu XM, Xiao B, Shu Y (2020) The runx1\/notch1 signaling pathway participates in m1\/m2 microglia polarization in a mouse model of temporal lobe epilepsy and in bv-2 cells. Neurochem Res 45:2204\u20132216. https:\/\/doi.org\/10.1007\/s11064-020-03082-3","journal-title":"Neurochem Res"},{"key":"1877_CR14","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s10571-022-01226-3","volume":"43","author":"D Dilimulati","year":"2023","unstructured":"Dilimulati D, Zhang F, Shao S, Lv T, Lu Q, Cao M, Jin Y, Jia F, Zhang X (2023) Ketogenic diet modulates neuroinflammation via metabolites from lactobacillus reuteri after repetitive mild traumatic brain injury in adolescent mice. Cell Mol Neurobiol 43:907\u2013923. https:\/\/doi.org\/10.1007\/s10571-022-01226-3","journal-title":"Cell Mol Neurobiol"},{"key":"1877_CR15","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.1002\/alz.13007","volume":"19","author":"AH Dilmore","year":"2023","unstructured":"Dilmore AH, Martino C, Neth BJ, West KA, Zemlin J, Rahman G, Panitchpakdi M, Meehan MJ, Weldon KC, Blach C, Schimmel L, Kaddurah-Daouk R, Dorrestein PC, Knight R, Craft S (2023) Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for alzheimer\u2019s disease. Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc 19:4805\u20134816. https:\/\/doi.org\/10.1002\/alz.13007","journal-title":"Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc"},{"key":"1877_CR17","doi-asserted-by":"publisher","first-page":"835217","DOI":"10.3389\/fcimb.2022.835217","volume":"12","author":"X Ding","year":"2022","unstructured":"Ding X, Zhou J, Zhao L, Chen M, Wang S, Zhang M, Zhang X, Jiang G (2022) Intestinal flora composition determines microglia activation and improves epileptic episode progress. Front Cell Infect Microbiol 12:835217. https:\/\/doi.org\/10.3389\/fcimb.2022.835217","journal-title":"Front Cell Infect Microbiol"},{"key":"1877_CR16","doi-asserted-by":"publisher","first-page":"e70042","DOI":"10.1002\/cph4.70042","volume":"15","author":"SQ Ding","year":"2025","unstructured":"Ding SQ, Lei Y, Zhao ZM, Li XY, Lang JX, Zhang JK, Li YS, Zhang CD, Dai DQ (2025) Crosstalk between microbiome and ferroptosis in diseases: From mechanism to therapy. Compr Physiol 15:e70042. https:\/\/doi.org\/10.1002\/cph4.70042","journal-title":"Compr Physiol"},{"key":"1877_CR18","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.18632\/aging.102690","volume":"12","author":"C Duan","year":"2020","unstructured":"Duan C, Kuang L, Xiang X, Zhang J, Zhu Y, Wu Y, Yan Q, Liu L, Li T (2020) Activated drp1-mediated mitochondrial ros influence the gut microbiome and intestinal barrier after hemorrhagic shock. Aging (Albany N Y) 12:1397\u20131416. https:\/\/doi.org\/10.18632\/aging.102690","journal-title":"Aging (Albany N Y)"},{"key":"1877_CR19","doi-asserted-by":"publisher","unstructured":"Dynka D, Kowalcze K, Paziewska A (2022) The role of ketogenic diet in the treatment of neurological diseases. Nutrients 14. https:\/\/doi.org\/10.3390\/nu14235003","DOI":"10.3390\/nu14235003"},{"key":"1877_CR20","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1038\/533S104a","volume":"533","author":"M Eisenstein","year":"2016","unstructured":"Eisenstein M (2016) Microbiome: Bacterial broadband. Nature 533:S104\u2013106. https:\/\/doi.org\/10.1038\/533S104a","journal-title":"Nature"},{"key":"1877_CR21","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"D Erny","year":"2015","unstructured":"Erny D, Hrabe de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermohlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M (2015) Host microbiota constantly control maturation and function of microglia in the cns. Nat Neurosci 18:965\u2013977. https:\/\/doi.org\/10.1038\/nn.4030","journal-title":"Nat Neurosci"},{"key":"1877_CR22","doi-asserted-by":"publisher","unstructured":"Firrman J, Deyaert S, Mahalak KK, Liu L, Baudot A, Joossens M, Poppe J, Cameron SJS, Van den Abbeele P (2024) The bifidogenic effect of 2\u2019fucosyllactose is driven by age-specific bifidobacterium species, demonstrating age as an important factor for gut microbiome targeted precision medicine. Nutrients 17. https:\/\/doi.org\/10.3390\/nu17010151","DOI":"10.3390\/nu17010151"},{"key":"1877_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.4476","volume":"20","author":"TC Fung","year":"2017","unstructured":"Fung TC, Olson CA, Hsiao EY (2017) Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci 20:145\u2013155. https:\/\/doi.org\/10.1038\/nn.4476","journal-title":"Nat Neurosci"},{"key":"1877_CR24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","volume":"9","author":"JB Furness","year":"2012","unstructured":"Furness JB (2012) The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 9:286\u2013294. https:\/\/doi.org\/10.1038\/nrgastro.2012.32","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1877_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-1-4939-0897-4_3","volume":"817","author":"JB Furness","year":"2014","unstructured":"Furness JB, Callaghan BP, Rivera LR, Cho HJ (2014) The enteric nervous system and gastrointestinal innervation: Integrated local and central control. Adv Exp Med Biol 817:39\u201371. https:\/\/doi.org\/10.1007\/978-1-4939-0897-4_3","journal-title":"Adv Exp Med Biol"},{"key":"1877_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10571-026-01671-4","volume":"46","author":"PK Gopalakrishna","year":"2026","unstructured":"Gopalakrishna PK, Che Mohd Nassir CMN, Anandan S, Hussan F, Dandala KCR, Sura S, Jagadeesan S, Mohd Moklas MA, Vishnumukkala T, Hein ZM (2026) The immuno-glial connectome in alzheimer\u2019s disease: Integrating central and peripheral inflammatory networks. Cell Mol Neurobiol 46:31. https:\/\/doi.org\/10.1007\/s10571-026-01671-4","journal-title":"Cell Mol Neurobiol"},{"key":"1877_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12974-024-03116-5","volume":"21","author":"N Gu","year":"2024","unstructured":"Gu N, Yan J, Tang W, Zhang Z, Wang L, Li Z, Wang Y, Zhu Y, Tang S, Zhong J, Cheng C, Sun X, Huang Z (2024) Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury. J Neuroinflammation 21:147. https:\/\/doi.org\/10.1186\/s12974-024-03116-5","journal-title":"J Neuroinflammation"},{"key":"1877_CR28","doi-asserted-by":"publisher","first-page":"14184","DOI":"10.1038\/s41598-018-32366-6","volume":"8","author":"CL Hayes","year":"2018","unstructured":"Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF (2018) Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis. Sci Rep 8:14184. https:\/\/doi.org\/10.1038\/s41598-018-32366-6","journal-title":"Sci Rep"},{"key":"1877_CR30","doi-asserted-by":"publisher","first-page":"1480022","DOI":"10.3389\/fmicb.2024.1480022","volume":"15","author":"X He","year":"2024","unstructured":"He X, Zhang Y (2024) Changes in gut flora in patients with epilepsy: A systematic review and meta-analysis. Front Microbiol 15:1480022. https:\/\/doi.org\/10.3389\/fmicb.2024.1480022","journal-title":"Front Microbiol"},{"key":"1877_CR29","doi-asserted-by":"publisher","first-page":"e14854","DOI":"10.1111\/cns.14854","volume":"30","author":"F He","year":"2024","unstructured":"He F, Ye L, Wang L, Zhou J, Shao X, Miao P, Wang S, Li H, Ding Y, Wang S (2024) Ketogenic diet therapy leads to antiseizure medication reduction in children and adults with drug-resistant epilepsy. CNS Neurosci Ther 30:e14854. https:\/\/doi.org\/10.1111\/cns.14854","journal-title":"CNS Neurosci Ther"},{"key":"1877_CR31","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s12035-025-05602-0","volume":"63","author":"ZM Hein","year":"2025","unstructured":"Hein ZM, Karikalan B, Gopalakrishna PK, Dhevi K, Alkatiri A, Hussan F, Mohd Moklas MA, Jagadeesan S, Che Ramli MD, Che Mohd Nassir CMN, Vishnumukkala T (2025) Toward a unified framework in molecular neurobiology of alzheimer\u2019s disease: Revisiting the pathophysiological hypotheses. Mol Neurobiol 63:282. https:\/\/doi.org\/10.1007\/s12035-025-05602-0","journal-title":"Mol Neurobiol"},{"key":"1877_CR32","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-025-03419-1","volume":"22","author":"M Holcomb","year":"2025","unstructured":"Holcomb M, Marshall AG, Flinn H, Lozano-Cavazos M, Soriano S, Gomez-Pinilla F, Treangen TJ, Villapol S (2025) Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury. J Neuroinflamm 22:114. https:\/\/doi.org\/10.1186\/s12974-025-03419-1","journal-title":"J Neuroinflamm"},{"key":"1877_CR33","doi-asserted-by":"publisher","first-page":"1254610","DOI":"10.3389\/fcimb.2023.1254610","volume":"13","author":"X Hu","year":"2023","unstructured":"Hu X, Jin H, Yuan S, Ye T, Chen Z, Kong Y, Liu J, Xu K, Sun J (2023) Fecal microbiota transplantation inhibited neuroinflammation of traumatic brain injury in mice via regulating the gut-brain axis. Front Cell Infect Microbiol 13:1254610. https:\/\/doi.org\/10.3389\/fcimb.2023.1254610","journal-title":"Front Cell Infect Microbiol"},{"key":"1877_CR34","doi-asserted-by":"publisher","unstructured":"Ikeda T, Takii K, Omichi Y, Nishimoto Y, Ichikawa D, Matsunaga T, Kawauchi A, Kimura I (2025) Hexanoic acid improves metabolic health in mice fed high-fat diet. Nutrients 17. https:\/\/doi.org\/10.3390\/nu17172868","DOI":"10.3390\/nu17172868"},{"key":"1877_CR35","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1007\/s11010-025-05376-y","volume":"480","author":"H Jia","year":"2025","unstructured":"Jia H, Guo X, Wei Y, Can C, He N, Zhang H, Yang X, Wu H, Liu W, Ma D (2025) Chronic stress, gut microbiota, and immunity: Interconnections and implications for health. Mol Cell Biochem 480:5995\u20136014. https:\/\/doi.org\/10.1007\/s11010-025-05376-y","journal-title":"Mol Cell Biochem"},{"key":"1877_CR36","doi-asserted-by":"publisher","first-page":"1732234","DOI":"10.3389\/fcimb.2025.1732234","volume":"15","author":"X Jin","year":"2025","unstructured":"Jin X, Cai H, Li Z (2025) Integrating microbial genomics and neurotranscriptomics to understand the impact of probiotic strains on neurological health. Front Cell Infect Microbiol 15:1732234. https:\/\/doi.org\/10.3389\/fcimb.2025.1732234","journal-title":"Front Cell Infect Microbiol"},{"key":"1877_CR37","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nature10213","volume":"474","author":"AL Kau","year":"2011","unstructured":"Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI (2011) Human nutrition, the gut microbiome and the immune system. Nature 474:327\u2013336. https:\/\/doi.org\/10.1038\/nature10213","journal-title":"Nature"},{"key":"1877_CR38","doi-asserted-by":"publisher","unstructured":"Kumar J (2025) Microbial metabolites and cardiovascular dysfunction: A new era of diagnostics and therapy. Cells 14. https:\/\/doi.org\/10.3390\/cells14161237","DOI":"10.3390\/cells14161237"},{"key":"1877_CR43","doi-asserted-by":"publisher","first-page":"e13433","DOI":"10.1111\/asj.13433","volume":"91","author":"Q Li","year":"2020","unstructured":"Li Q, Wan G, Peng C, Xu L, Yu Y, Li L, Li G (2020) Effect of probiotic supplementation on growth performance, intestinal morphology, barrier integrity, and inflammatory response in broilers subjected to cyclic heat stress. Anim Sci J = Nihon chikusan Gakkaiho 91:e13433. https:\/\/doi.org\/10.1111\/asj.13433","journal-title":"Anim Sci J = Nihon chikusan Gakkaiho"},{"key":"1877_CR42","doi-asserted-by":"publisher","first-page":"104071","DOI":"10.1016\/j.jprot.2020.104071","volume":"232","author":"N Li","year":"2021","unstructured":"Li N, Liang S, Chen Q, Zhao L, Li B, Huo G (2021) Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy chinese infants. J Proteom 232:104071. https:\/\/doi.org\/10.1016\/j.jprot.2020.104071","journal-title":"J Proteom"},{"key":"1877_CR39","doi-asserted-by":"publisher","first-page":"109904","DOI":"10.1016\/j.abb.2024.109904","volume":"753","author":"HZ Li","year":"2024","unstructured":"Li HZ, Han D, Ao RF, Cai ZH, Zhu GZ, Wu DZ, Gao JW, Zhuang JS, Tu C, Zhao K, Wu ZY, Zhong ZM (2024a) Tanshinone iia attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone. Arch Biochem Biophys 753:109904. https:\/\/doi.org\/10.1016\/j.abb.2024.109904","journal-title":"Arch Biochem Biophys"},{"key":"1877_CR41","doi-asserted-by":"publisher","first-page":"e0360823","DOI":"10.1128\/spectrum.03608-23","volume":"12","author":"M Li","year":"2024","unstructured":"Li M, Xue Y, Lu H, Bai J, Cui L, Ning Y, Yuan Q, Jia X, Wang S (2024b) Relationship between infant gastrointestinal microorganisms and maternal microbiome within 6 months of delivery. Microbiol Spectr 12:e0360823. https:\/\/doi.org\/10.1128\/spectrum.03608-23","journal-title":"Microbiol Spectr"},{"key":"1877_CR40","doi-asserted-by":"publisher","first-page":"eadw8410","DOI":"10.1126\/sciadv.adw8410","volume":"11","author":"L Li","year":"2025","unstructured":"Li L, Jia M, Yang C, Zhao Y, Hu J, Zhao Y, Hu X, Ning F, Ding C, Li Q, Gong J, Jia X, Xu K, Wang Y, Zhou S, Deng L, Shi L, Chen X, Liu X, Liu Z (2025a) Gut microbial-derived indole-3-propionate improves cognitive function in alzheimer\u2019s disease. Sci Adv 11:eadw8410. https:\/\/doi.org\/10.1126\/sciadv.adw8410","journal-title":"Sci Adv"},{"key":"1877_CR44","doi-asserted-by":"publisher","first-page":"101291","DOI":"10.1016\/j.jpha.2025.101291","volume":"15","author":"X Li","year":"2025","unstructured":"Li X, Ji J, Li J, Li S, Luo Q, Gu M, Yin X, Zhang M, Fan H, Yao R (2025b) Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through ho-1 dependent ferroptosis. J Pharm Anal 15:101291. https:\/\/doi.org\/10.1016\/j.jpha.2025.101291","journal-title":"J Pharm Anal"},{"key":"1877_CR45","doi-asserted-by":"publisher","first-page":"122623","DOI":"10.1016\/j.envres.2025.122623","volume":"285","author":"X Li","year":"2025","unstructured":"Li X, Li J, Zhou J, Ayada I, Pan Q, van der Laan LJW, Li P (2025c) Mapping the association between environmental pollutants and steatotic liver disease: A systematic review and meta-analysis. Environ Res 285:122623. https:\/\/doi.org\/10.1016\/j.envres.2025.122623","journal-title":"Environ Res"},{"key":"1877_CR46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.20517\/mrr.2021.09","volume":"1","author":"K Linehan","year":"2022","unstructured":"Linehan K, Dempsey EM, Ryan CA, Ross RP, Stanton C (2022) First encounters of the microbial kind: Perinatal factors direct infant gut microbiome establishment. Microbiome Res Rep 1:10. https:\/\/doi.org\/10.20517\/mrr.2021.09","journal-title":"Microbiome Res Rep"},{"key":"1877_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13578-020-00387-2","volume":"10","author":"L Liu","year":"2020","unstructured":"Liu L, Xu Y, Dai H, Tan S, Mao X, Chen Z (2020) Dynorphin activation of kappa opioid receptor promotes microglial polarization toward m2 phenotype via tlr4\/nf-\u03bab pathway. Cell Biosci 10:42. https:\/\/doi.org\/10.1186\/s13578-020-00387-2","journal-title":"Cell Biosci"},{"key":"1877_CR48","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.3390\/cimb45040232","volume":"45","author":"L Lopez-Pingarron","year":"2023","unstructured":"Lopez-Pingarron L, Almeida H, Soria-Aznar M, Reyes-Gonzales MC, Rodriguez-Moratinos AB, Munoz-Hoyos A, Garcia JJ (2023) Interstitial cells of cajal and enteric nervous system in gastrointestinal and neurological pathology, relation to oxidative stress. Curr Issues Mol Biol 45:3552\u20133572. https:\/\/doi.org\/10.3390\/cimb45040232","journal-title":"Curr Issues Mol Biol"},{"key":"1877_CR49","doi-asserted-by":"publisher","unstructured":"Lou M, Heuckeroth RO, Tjaden NEB (2024) Neuroimmune crossroads: The interplay of the enteric nervous system and intestinal macrophages in gut homeostasis and disease. Biomolecules 14. https:\/\/doi.org\/10.3390\/biom14091103","DOI":"10.3390\/biom14091103"},{"key":"1877_CR50","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nature11550","volume":"489","author":"CA Lozupone","year":"2012","unstructured":"Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R (2012) Diversity, stability and resilience of the human gut microbiota. Nature 489:220\u2013230. https:\/\/doi.org\/10.1038\/nature11550","journal-title":"Nature"},{"key":"1877_CR51","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12974-025-03476-6","volume":"22","author":"K Luo","year":"2025","unstructured":"Luo K, Zhang M, Tu Q, Li J, Wang Y, Wan S, Li D, Qian Q, Xia L (2025) From gut inflammation to psychiatric comorbidity: Mechanisms and therapies for anxiety and depression in inflammatory bowel disease. J Neuroinflammation 22:149. https:\/\/doi.org\/10.1186\/s12974-025-03476-6","journal-title":"J Neuroinflammation"},{"key":"1877_CR52","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.immuni.2023.07.011","volume":"56","author":"AJ Macpherson","year":"2023","unstructured":"Macpherson AJ, Pachnis V, Prinz M (2023) Boundaries and integration between microbiota, the nervous system, and immunity. Immunity 56:1712\u20131726. https:\/\/doi.org\/10.1016\/j.immuni.2023.07.011","journal-title":"Immunity"},{"key":"1877_CR53","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3748\/wjg.v22.i1.361","volume":"22","author":"F Mangiola","year":"2016","unstructured":"Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A (2016) Gut microbiota in autism and mood disorders. World J Gastroenterol 22:361\u2013368. https:\/\/doi.org\/10.3748\/wjg.v22.i1.361","journal-title":"World J Gastroenterol"},{"key":"1877_CR54","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1172\/JCI76304","volume":"125","author":"EA Mayer","year":"2015","unstructured":"Mayer EA, Tillisch K, Gupta A (2015) Gut\/brain axis and the microbiota. J Clin Invest 125:926\u2013938. https:\/\/doi.org\/10.1172\/JCI76304","journal-title":"J Clin Invest"},{"key":"1877_CR55","doi-asserted-by":"publisher","first-page":"166491","DOI":"10.1016\/j.bbadis.2022.166491","volume":"1868","author":"NM Mercado","year":"2022","unstructured":"Mercado NM, Zhang G, Ying Z, Gomez-Pinilla F (2022a) Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs. Biochim Biophys Acta Mol Basis Dis 1868:166491. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166491","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1877_CR56","doi-asserted-by":"publisher","first-page":"166491","DOI":"10.1016\/j.bbadis.2022.166491","volume":"1868","author":"NM Mercado","year":"2022","unstructured":"Mercado NM, Zhang G, Ying Z, G\u00f3mez-Pinilla F (2022b) Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs. Biochim et Biophys acta Mol basis disease 1868:166491. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166491","journal-title":"Biochim et Biophys acta Mol basis disease"},{"key":"1877_CR57","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/s42003-024-06470-5","volume":"7","author":"L Moadi","year":"2024","unstructured":"Moadi L, Turjeman S, Asulin N, Koren O (2024) The effect of testosterone on the gut microbiome in mice. Commun biology 7:880. https:\/\/doi.org\/10.1038\/s42003-024-06470-5","journal-title":"Commun biology"},{"key":"1877_CR58","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1038\/s41598-021-81717-3","volume":"11","author":"CR Muller","year":"2021","unstructured":"Muller CR, Courelli V, Lucas A, Williams AT, Li JB, Dos Santos F, Cuddington CT, Moses SR, Palmer AF, Kistler EB, Cabrales P (2021) Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin. Sci Rep 11:2509. https:\/\/doi.org\/10.1038\/s41598-021-81717-3","journal-title":"Sci Rep"},{"key":"1877_CR59","doi-asserted-by":"publisher","first-page":"e70586","DOI":"10.1096\/fj.202500220RR","volume":"39","author":"E Nikolla","year":"2025","unstructured":"Nikolla E, Grandberry A, Jamerson D, Flynn CR, Sundaresan S (2025) The enteric neuronal circuitry: A key ignored player in nutrient sensing along the gut-brain axis. FASEB J 39:e70586. https:\/\/doi.org\/10.1096\/fj.202500220RR","journal-title":"FASEB J"},{"key":"1877_CR60","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.cell.2018.04.027","volume":"173","author":"CA Olson","year":"2018","unstructured":"Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY (2018) The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell 173:1728\u20131741e1713. https:\/\/doi.org\/10.1016\/j.cell.2018.04.027","journal-title":"Cell"},{"key":"1877_CR61","doi-asserted-by":"publisher","first-page":"102708","DOI":"10.1016\/j.coi.2025.102708","volume":"98","author":"M Peng","year":"2026","unstructured":"Peng M, Sun H (2026) The indole-brain connection: Neuroimmune mechanisms and therapy. Curr Opin Immunol 98:102708. https:\/\/doi.org\/10.1016\/j.coi.2025.102708","journal-title":"Curr Opin Immunol"},{"key":"1877_CR62","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2119\/molmed.2011.00390","volume":"18","author":"L Qi","year":"2012","unstructured":"Qi L, Cui X, Dong W, Barrera R, Nicastro J, Coppa GF, Wang P, Wu R (2012) Ghrelin attenuates brain injury after traumatic brain injury and uncontrolled hemorrhagic shock in rats. Mol Med 18:186\u2013193. https:\/\/doi.org\/10.2119\/molmed.2011.00390","journal-title":"Mol Med"},{"key":"1877_CR63","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s11910-017-0802-6","volume":"17","author":"EMM Quigley","year":"2017","unstructured":"Quigley EMM (2017) Microbiota-brain-gut axis and neurodegenerative diseases. Curr Neurol Neurosci Rep 17:94. https:\/\/doi.org\/10.1007\/s11910-017-0802-6","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1877_CR64","doi-asserted-by":"publisher","unstructured":"Ren J, Wang Q, Hong H, Tang C (2025) Fecal microbiota transplantation in alzheimer\u2019s disease: Mechanistic insights through the microbiota-gut-brain axis and therapeutic prospects. Microorganisms 13. https:\/\/doi.org\/10.3390\/microorganisms13081956","DOI":"10.3390\/microorganisms13081956"},{"key":"1877_CR65","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.amjmed.2025.05.044","volume":"138","author":"M Ring","year":"2025","unstructured":"Ring M (2025) An integrative approach to hpa axis dysfunction: From recognition to recovery. Am J Med 138:1451\u20131463. https:\/\/doi.org\/10.1016\/j.amjmed.2025.05.044","journal-title":"Am J Med"},{"key":"1877_CR66","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3748\/wjg.v28.i18.1875","volume":"28","author":"NK Saeed","year":"2022","unstructured":"Saeed NK, Al-Beltagi M, Bediwy AS, El-Sawaf Y, Toema O (2022) Gut microbiota in various childhood disorders: Implication and indications. World J Gastroenterol 28:1875\u20131901. https:\/\/doi.org\/10.3748\/wjg.v28.i18.1875","journal-title":"World J Gastroenterol"},{"key":"1877_CR67","doi-asserted-by":"publisher","first-page":"1487641","DOI":"10.3389\/fmicb.2024.1487641","volume":"15","author":"B Sarita","year":"2024","unstructured":"Sarita B, Samadhan D, Hassan MZ, Kovaleva EG (2024) A comprehensive review of probiotics and human health-current prospective and applications. Front Microbiol 15:1487641. https:\/\/doi.org\/10.3389\/fmicb.2024.1487641","journal-title":"Front Microbiol"},{"key":"1877_CR68","doi-asserted-by":"publisher","unstructured":"Savulescu-Fiedler I, Benea SN, Caruntu C, Nancoff AS, Homentcovschi C, Bucurica S (2025) Rewiring the brain through the gut: Insights into microbiota-nervous system interactions. Curr Issues Mol Biol 47. https:\/\/doi.org\/10.3390\/cimb47070489","DOI":"10.3390\/cimb47070489"},{"key":"1877_CR69","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.024","volume":"28","author":"S Shaafi","year":"2019","unstructured":"Shaafi S, Sharifi-Bonab M, Ghaemian N, Mokhtarkhani M, Akbari H (2019) Early motor-behavioral outcome of ischemic stroke with ketogenic diet preconditioning: Interventional animal study. J Stroke Cerebrovasc Dis 28:1032\u20131039. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.12.024","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1877_CR70","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41586-019-1560-1","volume":"574","author":"Y Shao","year":"2019","unstructured":"Shao Y, Forster SC, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD (2019) Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature 574:117\u2013121. https:\/\/doi.org\/10.1038\/s41586-019-1560-1","journal-title":"Nature"},{"key":"1877_CR71","doi-asserted-by":"publisher","first-page":"e1782","DOI":"10.1093\/nutrit\/nuae180","volume":"83","author":"D Sivri","year":"2025","unstructured":"Sivri D, \u015eeref B, \u015eare Bulut M, Gezmen Karada\u011f M (2025) Evaluation of the effect of probiotic supplementation on intestinal barrier integrity and epithelial damage in colitis disease: A systematic review. Nutr Rev 83:e1782\u2013e1797. https:\/\/doi.org\/10.1093\/nutrit\/nuae180","journal-title":"Nutr Rev"},{"key":"1877_CR72","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/nri.2017.100","volume":"17","author":"I Spadoni","year":"2017","unstructured":"Spadoni I, Fornasa G, Rescigno M (2017) Organ-specific protection mediated by cooperation between vascular and epithelial barriers. Nat Rev Immunol 17:761\u2013773. https:\/\/doi.org\/10.1038\/nri.2017.100","journal-title":"Nat Rev Immunol"},{"key":"1877_CR73","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1172\/JCI72332","volume":"124","author":"NK Surana","year":"2014","unstructured":"Surana NK, Kasper DL (2014) Deciphering the tete-a-tete between the microbiota and the immune system. J Clin Invest 124:4197\u20134203. https:\/\/doi.org\/10.1172\/JCI72332","journal-title":"J Clin Invest"},{"key":"1877_CR74","doi-asserted-by":"publisher","unstructured":"Szegedi I, Bomberak D, Eles Z, Loczi L, Bagoly Z (2025) Cardiovascular disease and microbiome: Focus on ischemic stroke. Pol Arch Intern Med 135. https:\/\/doi.org\/10.20452\/pamw.17088","DOI":"10.20452\/pamw.17088"},{"key":"1877_CR75","doi-asserted-by":"publisher","unstructured":"Tian F, Gao X, Zhang L, Wang X, Wan X, Jiang T, Wu C, Bi J, Lei Q (2016) Effects of n-3 pufas on intestinal mucosa innate immunity and intestinal microbiota in mice after hemorrhagic shock resuscitation. Nutrients 8. https:\/\/doi.org\/10.3390\/nu8100609","DOI":"10.3390\/nu8100609"},{"key":"1877_CR76","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s40168-021-01165-z","volume":"9","author":"FA Vicentini","year":"2021","unstructured":"Vicentini FA, Keenan CM, Wallace LE, Woods C, Cavin JB, Flockton AR, Macklin WB, Belkind-Gerson J, Hirota SA, Sharkey KA (2021) Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia. Microbiome 9:210. https:\/\/doi.org\/10.1186\/s40168-021-01165-z","journal-title":"Microbiome"},{"key":"1877_CR77","doi-asserted-by":"publisher","unstructured":"Wang S, Shang Y, Pi Z, Zhou Z, Zhang X, Ren L, Liang W, Guo Y, Cai J, Zhang C (2023) Temporal changes of the oral and fecal microbiota after mild traumatic brain injury in rats by 16s rrna sequencing. https:\/\/doi.org\/10.3390\/microorganisms11061452. Microorganisms 11","DOI":"10.3390\/microorganisms11061452"},{"key":"1877_CR78","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.bbi.2024.10.026","volume":"123","author":"YH Wang","year":"2025","unstructured":"Wang YH, Liao JM, Jan MS, Wang M, Su HH, Tsai WH, Liu PH, Tsuei YS, Huang SS (2025) Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis. Brain Behav Immun 123:784\u2013798. https:\/\/doi.org\/10.1016\/j.bbi.2024.10.026","journal-title":"Brain Behav Immun"},{"key":"1877_CR79","doi-asserted-by":"publisher","first-page":"1385469","DOI":"10.3389\/fvets.2024.1385469","volume":"11","author":"A Watanangura","year":"2024","unstructured":"Watanangura A, Meller S, Farhat N, Suchodolski JS, Pilla R, Khattab MR, Lopes BC, Bathen-Nothen A, Fischer A, Busch-Hahn K, Flieshardt C, Gramer M, Richter F, Zamansky A, Volk HA (2024) Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: A pilot study of a novel therapeutic approach. Front Vet Sci 11:1385469. https:\/\/doi.org\/10.3389\/fvets.2024.1385469","journal-title":"Front Vet Sci"},{"key":"1877_CR80","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/toxsci\/kfw046","volume":"151","author":"J Wu","year":"2016","unstructured":"Wu J, Wen XW, Faulk C, Boehnke K, Zhang H, Dolinoy DC, Xi C (2016) Perinatal lead exposure alters gut microbiota composition and results in sex-specific bodyweight increases in adult mice. Toxicol Sci 151:324\u2013333. https:\/\/doi.org\/10.1093\/toxsci\/kfw046","journal-title":"Toxicol Sci"},{"key":"1877_CR81","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ibneur.2025.02.007","volume":"18","author":"H Yan","year":"2025","unstructured":"Yan H, Hua Y, Ni J, Wu X, Xu J, Zhang Z, Dong J, Xiong Z, Yang L, Yuan H (2025) Acupuncture ameliorates inflammation by regulating gut microbiota in acute ischemic stroke. IBRO Neurosci Rep 18:443\u2013452. https:\/\/doi.org\/10.1016\/j.ibneur.2025.02.007","journal-title":"IBRO Neurosci Rep"},{"key":"1877_CR82","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature11053","volume":"486","author":"T Yatsunenko","year":"2012","unstructured":"Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI (2012) Human gut microbiome viewed across age and geography. Nature 486:222\u2013227. https:\/\/doi.org\/10.1038\/nature11053","journal-title":"Nature"},{"key":"1877_CR83","doi-asserted-by":"publisher","first-page":"1636860","DOI":"10.3389\/fmed.2025.1636860","volume":"12","author":"F Ye","year":"2025","unstructured":"Ye F, Li H, Li H, Mu X (2025) Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke. Front Med 12:1636860. https:\/\/doi.org\/10.3389\/fmed.2025.1636860","journal-title":"Front Med"},{"key":"1877_CR84","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.2147\/dddt.S246619","volume":"14","author":"F Yuan","year":"2020","unstructured":"Yuan F, Tan W, Ren H, Yan L, Wang Y, Luo H (2020) The effects of short-chain fatty acids on rat colonic hypermotility induced by water avoidance stress. Drug Des Devel Ther 14:4671\u20134684. https:\/\/doi.org\/10.2147\/dddt.S246619","journal-title":"Drug Des Devel Ther"},{"key":"1877_CR87","doi-asserted-by":"publisher","unstructured":"Zhang Y, Zhang J, Xu T, Zhang C, Yu WQ, Wei T, Zhang B, Chen Q, Qiu JY, Li HJ, Liang TB (2021) Role of tlr5 in the translocation and dissemination of commensal bacteria in the intestine after traumatic hemorrhagic shock. J Immunol Res 2021:6417658. https:\/\/doi.org\/10.1155\/2021\/6417658","DOI":"10.1155\/2021\/6417658"},{"key":"1877_CR85","doi-asserted-by":"publisher","first-page":"785644","DOI":"10.3389\/fimmu.2022.785644","volume":"13","author":"H Zhang","year":"2022","unstructured":"Zhang H, Chen Y, Wang Z, Xie G, Liu M, Yuan B, Chai H, Wang W, Cheng P (2022) Implications of gut microbiota in neurodegenerative diseases. Front Immunol 13:785644. https:\/\/doi.org\/10.3389\/fimmu.2022.785644","journal-title":"Front Immunol"},{"key":"1877_CR86","doi-asserted-by":"publisher","first-page":"155530","DOI":"10.1016\/j.phymed.2024.155530","volume":"128","author":"S Zhang","year":"2024","unstructured":"Zhang S, Chen Q, Jin M, Ren J, Sun X, Zhang Z, Luo Y, Sun X (2024) Notoginsenoside r1 alleviates cerebral ischemia\/reperfusion injury by inhibiting the tlr4\/myd88\/nf-kappab signaling pathway through microbiota-gut-brain axis. Phytomedicine 128:155530. https:\/\/doi.org\/10.1016\/j.phymed.2024.155530","journal-title":"Phytomedicine"},{"key":"1877_CR89","doi-asserted-by":"publisher","first-page":"1609960","DOI":"10.3389\/fimmu.2025.1609960","volume":"16","author":"S Zhao","year":"2025","unstructured":"Zhao S, Fu D, Lin Y, Sun X, Wang X, Wu X, Zhang X (2025a) The role of the microbiome on immune homeostasis of the host nervous system. Front Immunol 16:1609960. https:\/\/doi.org\/10.3389\/fimmu.2025.1609960","journal-title":"Front Immunol"},{"key":"1877_CR90","doi-asserted-by":"publisher","unstructured":"Zhao X, Zheng I, Huang W, Tang D, Zhao M, Hou R, Huang Y, Shi Y, Zhu W, Wang S (2025b) Research progress on the mechanism of bile acids and their receptors in depression. Int J Mol Sci 26. https:\/\/doi.org\/10.3390\/ijms26094023","DOI":"10.3390\/ijms26094023"},{"key":"1877_CR88","doi-asserted-by":"publisher","unstructured":"Zhao M, Liu Q, Shi NJ, Li Y, Li HB (2026) Gut microbiota and hypertension: Role of exercise training. Clin experimental Hypertens (New York NY: 1993) 48(2608905). https:\/\/doi.org\/10.1080\/10641963.2025.2608905","DOI":"10.1080\/10641963.2025.2608905"},{"key":"1877_CR91","doi-asserted-by":"publisher","unstructured":"Zheng Y, Bonfili L, Wei T, Eleuteri AM (2023) Understanding the gut-brain axis and its therapeutic implications for neurodegenerative disorders. Nutrients 15. https:\/\/doi.org\/10.3390\/nu15214631","DOI":"10.3390\/nu15214631"},{"key":"1877_CR92","doi-asserted-by":"publisher","first-page":"965471","DOI":"10.3389\/fcimb.2022.965471","volume":"12","author":"C Zhou","year":"2022","unstructured":"Zhou C, Gong S, Xiang S, Liang L, Hu X, Huang R, Liao Z, Ma Y, Xiao Z, Qiu J (2022) Changes and significance of gut microbiota in children with focal epilepsy before and after treatment. Front Cell Infect Microbiol 12:965471. https:\/\/doi.org\/10.3389\/fcimb.2022.965471","journal-title":"Front Cell Infect Microbiol"},{"key":"1877_CR93","doi-asserted-by":"publisher","first-page":"112881","DOI":"10.1016\/j.intimp.2024.112881","volume":"141","author":"M Zhou","year":"2024","unstructured":"Zhou M, Wu J, Shao Y, Zhang J, Zheng R, Shi Q, Wang J, Liu B (2024) Short-chain fatty acids reverses gut microbiota dysbiosis-promoted progression of glioblastoma by up-regulating m1 polarization in the tumor microenvironment. Int Immunopharmacol 141:112881. https:\/\/doi.org\/10.1016\/j.intimp.2024.112881","journal-title":"Int Immunopharmacol"},{"key":"1877_CR94","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.chom.2021.05.002","volume":"29","author":"W Zhu","year":"2021","unstructured":"Zhu W, Romano KA, Li L, Buffa JA, Sangwan N, Prakash P, Tittle AN, Li XS, Fu X, Androjna C, DiDonato AJ, Brinson K, Trapp BD, Fischbach MA, Rey FE, Hajjar AM, DiDonato JA, Hazen SL (2021) Gut microbes impact stroke severity via the trimethylamine n-oxide pathway. Cell Host Microbe 29:1199\u20131208e1195. https:\/\/doi.org\/10.1016\/j.chom.2021.05.002","journal-title":"Cell Host Microbe"},{"key":"1877_CR95","doi-asserted-by":"publisher","first-page":"2387800","DOI":"10.1080\/19490976.2024.2387800","volume":"16","author":"M Zhuang","year":"2024","unstructured":"Zhuang M, Zhang X, Cai J (2024) Microbiota-gut-brain axis: Interplay between microbiota, barrier function and lymphatic system. Gut Microbes 16:2387800. https:\/\/doi.org\/10.1080\/19490976.2024.2387800","journal-title":"Gut Microbes"},{"key":"1877_CR96","doi-asserted-by":"publisher","unstructured":"Zubareva OE, Dyomina AV, Kovalenko AA, Roginskaya AI, Melik-Kasumov TB, Korneeva MA, Chuprina AV, Zhabinskaya AA, Kolyhan SA, Zakharova MV, Gryaznova MO, Zaitsev AV (2023) Beneficial effects of probiotic bifidobacterium longum in a lithium-pilocarpine model of temporal lobe epilepsy in rats. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/ijms24098451","DOI":"10.3390\/ijms24098451"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01877-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01877-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01877-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:00:21Z","timestamp":1781330421000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01877-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1877"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01877-x","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"16 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors read and approved the final manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors statement"}},{"value":"During the preparation of this manuscript, we used Deepseek and Paperpal Preflight to assist with language refinement and to address common errors and omissions. Subsequently, the content was thoroughly reviewed and edited as necessary, and the authors take full responsibility for the content of the publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI and AI-assisted technologies in the writing process"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"134"}}