{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:23Z","timestamp":1787822363248,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01953-2","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:30:59Z","timestamp":1787819459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5350-3984","authenticated-orcid":false,"given":"Kankipati","family":"Sravya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9308-3481","authenticated-orcid":false,"given":"Arpitha","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5545-5103","authenticated-orcid":false,"given":"P.","family":"Harshitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6121-3236","authenticated-orcid":false,"given":"Aluru","family":"Parithathvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-9595","authenticated-orcid":false,"given":"Herman Sunil","family":"Dsouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"1953_CR1","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1007\/978-3-031-15080-7_231","volume-title":"Handbook of Neurotoxicity","author":"SC Bondy","year":"2022","unstructured":"Bondy SC, Campbell A (2022) Aluminum and Neurodegenerative Disease. Handbook of Neurotoxicity. Springer, Cham, pp 2283\u20132303"},{"key":"1953_CR2","doi-asserted-by":"publisher","first-page":"39176","DOI":"10.1074\/jbc.M303516200","volume":"278","author":"CD Bortner","year":"2003","unstructured":"Bortner CD, Cidlowski JA (2003) Uncoupling Cell Shrinkage from Apoptosis Reveals That Na+ Influx Is Required for Volume Loss during Programmed Cell Death*. J Biol Chem 278:39176\u201339184. https:\/\/doi.org\/10.1074\/jbc.M303516200","journal-title":"J Biol Chem"},{"key":"1953_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.chemosphere.2016.02.092","volume":"151","author":"Z Cao","year":"2016","unstructured":"Cao Z, Yang X, Zhang H et al (2016) Aluminum chloride induces neuroinflammation, loss of neuronal dendritic spine and cognition impairment in developing rat. Chemosphere 151:289\u2013295. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.02.092","journal-title":"Chemosphere"},{"key":"1953_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.01.002","volume":"180","author":"L Chen","year":"2022","unstructured":"Chen L, Dar NJ, Na R et al (2022) Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice. Free Radic Biol Med 180:1\u201312. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.01.002","journal-title":"Free Radic Biol Med"},{"key":"1953_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/15376516.2020.1821268","volume":"31","author":"L Cheng","year":"2021","unstructured":"Cheng L, Liang R, Li Z et al (2021) Aluminum maltolate triggers ferroptosis in neurons: mechanism of action. Toxicol Mech Methods 31:33\u201342. https:\/\/doi.org\/10.1080\/15376516.2020.1821268","journal-title":"Toxicol Mech Methods"},{"key":"1953_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1515\/bmc-2012-0045","volume":"4","author":"G Crisponi","year":"2013","unstructured":"Crisponi G, Fanni D, Gerosa C et al (2013) The meaning of aluminium exposure on human health and aluminium-related diseases. Biomol Concepts 4:77\u201387. https:\/\/doi.org\/10.1515\/bmc-2012-0045","journal-title":"Biomol Concepts"},{"key":"1953_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178662","volume":"14","author":"Z Dai","year":"2023","unstructured":"Dai Z, Liu W-C, Chen X-Y et al (2023) Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors. Front Immunol 14:1178662. https:\/\/doi.org\/10.3389\/fimmu.2023.1178662","journal-title":"Front Immunol"},{"key":"1953_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s43440-022-00353-4","volume":"74","author":"M Dey","year":"2022","unstructured":"Dey M, Singh RK (2022) Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer\u2019s disease. Pharmacol Rep PR 74:439\u2013450. https:\/\/doi.org\/10.1007\/s43440-022-00353-4","journal-title":"Pharmacol Rep PR"},{"key":"1953_CR9","doi-asserted-by":"publisher","first-page":"6245","DOI":"10.1038\/onc.2008.301","volume":"27","author":"DN Dhanasekaran","year":"2008","unstructured":"Dhanasekaran DN, Reddy EP (2008) JNK Signalling in Apoptosis. Oncogene 27:6245\u20136251. https:\/\/doi.org\/10.1038\/onc.2008.301","journal-title":"Oncogene"},{"key":"1953_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuroscience.2024.06.011","volume":"556","author":"J Dong","year":"2024","unstructured":"Dong J, Gong Z, Bi H et al (2024) BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal cells caused by spinal cord injury via the UBE2Z\/NRF2 pathway. Neuroscience 556:73\u201385. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.06.011","journal-title":"Neuroscience"},{"key":"1953_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ymeth.2007.11.006","volume":"44","author":"F Doonan","year":"2008","unstructured":"Doonan F, Cotter TG (2008) Morphological assessment of apoptosis. Methods 44:200\u2013204. https:\/\/doi.org\/10.1016\/j.ymeth.2007.11.006","journal-title":"Methods"},{"key":"1953_CR13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0278-6915(00)00118-6","volume":"39","author":"R Flarend","year":"2001","unstructured":"Flarend R, Bin T, Elmore D, Hem SL (2001) A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem Toxicol 39:163\u2013168. https:\/\/doi.org\/10.1016\/S0278-6915(00)00118-6","journal-title":"Food Chem Toxicol"},{"key":"1953_CR14","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","volume":"98","author":"M Fricker","year":"2018","unstructured":"Fricker M, Tolkovsky AM, Borutaite V et al (2018) Neuronal cell death. Physiol Rev 98:813\u2013880. https:\/\/doi.org\/10.1152\/physrev.00011.2017","journal-title":"Physiol Rev"},{"key":"1953_CR15","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jinorgbio.2015.09.007","volume":"152","author":"A Fulgenzi","year":"2015","unstructured":"Fulgenzi A, De Giuseppe R, Bamonti F et al (2015) Efficacy of chelation therapy to remove aluminium intoxication. J Inorg Biochem 152:214\u2013218. https:\/\/doi.org\/10.1016\/j.jinorgbio.2015.09.007","journal-title":"J Inorg Biochem"},{"key":"1953_CR16","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.neuro.2003.12.004","volume":"25","author":"KJS Griffioen","year":"2004","unstructured":"Griffioen KJS, Ghribi O, Fox N et al (2004) Aluminum Maltolate-Induced Toxicity in NT2 Cells Occurs Through Apoptosis and Includes Cytochrome c Release. Neurotoxicology 25:859\u2013867. https:\/\/doi.org\/10.1016\/j.neuro.2003.12.004","journal-title":"Neurotoxicology"},{"key":"1953_CR18","doi-asserted-by":"publisher","first-page":"112591","DOI":"10.1016\/j.fct.2021.112591","volume":"157","author":"W Hao","year":"2021","unstructured":"Hao W, Hao C, Wu C et al (2021) Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signalling pathway. Food Chem Toxicol 157:112591. https:\/\/doi.org\/10.1016\/j.fct.2021.112591","journal-title":"Food Chem Toxicol"},{"key":"1953_CR19","doi-asserted-by":"publisher","first-page":"115401","DOI":"10.1016\/j.ecoenv.2023.115401","volume":"264","author":"W Hao","year":"2023","unstructured":"Hao W, Zhu X, Liu Z et al (2023) Aluminum exposure induces central nervous system impairment by activating NLRP3-medicated pyroptosis pathway. Ecotoxicol Environ Saf 264:115401. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115401","journal-title":"Ecotoxicol Environ Saf"},{"key":"1953_CR20","doi-asserted-by":"publisher","first-page":"127232","DOI":"10.1016\/j.jtemb.2023.127232","volume":"79","author":"C He","year":"2023","unstructured":"He C, Zhao X, Lei Y et al (2023a) The role of Nrf2\/HO-1 signalling pathway in regulating aluminum-induced apoptosis of PC12 cells. J Trace Elem Med Biol 79:127232. https:\/\/doi.org\/10.1016\/j.jtemb.2023.127232","journal-title":"J Trace Elem Med Biol"},{"key":"1953_CR21","doi-asserted-by":"publisher","first-page":"127232","DOI":"10.1016\/j.jtemb.2023.127232","volume":"79","author":"C He","year":"2023","unstructured":"He C, Zhao X, Lei Y et al (2023b) The role of Nrf2\/HO-1 signalling pathway in regulating aluminum-induced apoptosis of PC12 cells. J Trace Elem Med Biol 79:127232. https:\/\/doi.org\/10.1016\/j.jtemb.2023.127232","journal-title":"J Trace Elem Med Biol"},{"key":"1953_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155046","volume":"129","author":"S Hu","year":"2020","unstructured":"Hu S, Chang X, Zhu H et al (2020) PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signalling pathway activation. Cytokine 129:155046. https:\/\/doi.org\/10.1016\/j.cyto.2020.155046","journal-title":"Cytokine"},{"key":"1953_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4103\/jrms.JRMS_921_17","volume":"23","author":"E Inan-Eroglu","year":"2018","unstructured":"Inan-Eroglu E, Ayaz A (2018) Is aluminum exposure a risk factor for neurological disorders? J Res Med Sci Off J Isfahan Univ Med Sci 23:51. https:\/\/doi.org\/10.4103\/jrms.JRMS_921_17","journal-title":"J Res Med Sci Off J Isfahan Univ Med Sci"},{"key":"1953_CR24","volume-title":"Aluminum Toxicity","author":"JS Jackson","year":"2026","unstructured":"Jackson JS, Rout P (2026) Aluminum Toxicity. In: StatPearls. StatPearls Publishing, Treasure Island (FL)"},{"key":"1953_CR25","first-page":"917","volume":"43","author":"X Jia","year":"2014","unstructured":"Jia X, Zhang Q, Niu Q (2014) [MAPK signalling pathways involved in aluminum-induced apoptosis and necroptosis in SH-SY5Y cells]. Wei Sheng Yan Jiu 43:917\u2013922","journal-title":"Wei Sheng Yan Jiu"},{"key":"1953_CR26","volume-title":"Necrosis","author":"N Khalid","year":"2024","unstructured":"Khalid N, Azimpouran M (2024) Necrosis. In: StatPearls. StatPearls Publishing, Treasure Island (FL)"},{"issue":"Suppl 1","key":"1953_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10937400701597766","volume":"10","author":"D Krewski","year":"2007","unstructured":"Krewski D, Yokel RA, Nieboer E et al (2007) Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev 10(Suppl 1):1\u2013269. https:\/\/doi.org\/10.1080\/10937400701597766","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"1953_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ymeth.2007.12.001","volume":"44","author":"DV Krysko","year":"2008","unstructured":"Krysko DV, Vanden Berghe T, D\u2019Herde K, Vandenabeele P (2008) Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods 44:205\u2013221. https:\/\/doi.org\/10.1016\/j.ymeth.2007.12.001","journal-title":"Methods"},{"key":"1953_CR29","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.neuro.2014.02.004","volume":"41","author":"V Kumar","year":"2014","unstructured":"Kumar V, Gill KD (2014) Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review. Neurotoxicology 41:154\u2013166. https:\/\/doi.org\/10.1016\/j.neuro.2014.02.004","journal-title":"Neurotoxicology"},{"key":"1953_CR30","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1007\/s12640-020-00165-5","volume":"37","author":"H Li","year":"2020","unstructured":"Li H, Xue X, Li L et al (2020) Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signalling Pathway. Neurotox Res 37:996\u20131008. https:\/\/doi.org\/10.1007\/s12640-020-00165-5","journal-title":"Neurotox Res"},{"key":"1953_CR31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/sj.cr.7290262","volume":"15","author":"J Liu","year":"2005","unstructured":"Liu J, Lin A (2005) Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15:36\u201342. https:\/\/doi.org\/10.1038\/sj.cr.7290262","journal-title":"Cell Res"},{"key":"1953_CR32","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","volume":"73","author":"A Loboda","year":"2016","unstructured":"Loboda A, Damulewicz M, Pyza E et al (2016) Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci 73:3221\u20133247. https:\/\/doi.org\/10.1007\/s00018-016-2223-0","journal-title":"Cell Mol Life Sci"},{"key":"1953_CR33","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.3892\/etm.2017.4259","volume":"13","author":"Y Meng","year":"2017","unstructured":"Meng Y, Wang W, Kang J et al (2017) Role of the PI3K\/AKT signalling pathway in apoptotic cell death in the cerebral cortex of streptozotocin-induced diabetic rats. Exp Ther Med 13:2417\u20132422. https:\/\/doi.org\/10.3892\/etm.2017.4259","journal-title":"Exp Ther Med"},{"key":"1953_CR34","volume-title":"Neurotoxicity of Aluminum","year":"2023","unstructured":"Niu Q (ed) (2023) Neurotoxicity of Aluminum. Springer Nature Singapore, Singapore"},{"key":"1953_CR35","first-page":"532","volume":"33","author":"B Pan","year":"2015","unstructured":"Pan B, Guo S, Guo L et al (2015) [Effect of chronic aluminum exposure on neuron apoptosis and expression of P53 phosphorylation in rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Zhonghua Laodong Weisheng Zhiyebing Zazhi Chin. J Ind Hyg Occup Dis 33:532\u2013534","journal-title":"J Ind Hyg Occup Dis"},{"key":"1953_CR37","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.gendis.2023.01.009","volume":"11","author":"X Que","year":"2024","unstructured":"Que X, Zheng S, Song Q et al (2024) Fantastic voyage: The journey of NLRP3 inflammasome activation. Genes Dis 11:819\u2013829. https:\/\/doi.org\/10.1016\/j.gendis.2023.01.009","journal-title":"Genes Dis"},{"key":"1953_CR38","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.2165\/00002018-200326140-00003","volume":"26","author":"CM Reinke","year":"2003","unstructured":"Reinke CM, Breitkreutz J, Leuenberger H (2003) Aluminium in over-the-counter drugs: risks outweigh benefits? Drug Saf 26:1011\u20131025. https:\/\/doi.org\/10.2165\/00002018-200326140-00003","journal-title":"Drug Saf"},{"key":"1953_CR39","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3109\/10408444.2012.725027","volume":"42","author":"V Riihim\u00e4ki","year":"2012","unstructured":"Riihim\u00e4ki V, Aitio A (2012) Occupational exposure to aluminum and its biomonitoring in perspective. Crit Rev Toxicol 42:827\u2013853. https:\/\/doi.org\/10.3109\/10408444.2012.725027","journal-title":"Crit Rev Toxicol"},{"key":"1953_CR40","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12011-015-0553-7","volume":"172","author":"SHM Rizvi","year":"2016","unstructured":"Rizvi SHM, Parveen A, Ahmad I et al (2016) Aluminum Activates PERK-EIF2\u03b1 Signalling and Inflammatory Proteins in Human Neuroblastoma SH-SY5Y Cells. Biol Trace Elem Res 172:108\u2013119. https:\/\/doi.org\/10.1007\/s12011-015-0553-7","journal-title":"Biol Trace Elem Res"},{"key":"1953_CR41","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41586-019-1551-2","volume":"573","author":"P Samir","year":"2019","unstructured":"Samir P, Kesavardhana S, Patmore DM et al (2019) DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature 573:590\u2013594. https:\/\/doi.org\/10.1038\/s41586-019-1551-2","journal-title":"Nature"},{"key":"1953_CR42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12640-020-00230-z","volume":"38","author":"N Shang","year":"2020","unstructured":"Shang N, Zhang P, Wang S et al (2020) Aluminum-Induced Cognitive Impairment and PI3K\/Akt\/mTOR Signalling Pathway Involvement in Occupational Aluminum Workers. Neurotox Res 38:344\u2013358. https:\/\/doi.org\/10.1007\/s12640-020-00230-z","journal-title":"Neurotox Res"},{"key":"1953_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ant.2020.12.001","volume":"5","author":"AV Skalny","year":"2021","unstructured":"Skalny AV, Aschner M, Jiang Y et al (2021) Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. Adv Neurotoxicology 5:1\u201334. https:\/\/doi.org\/10.1016\/bs.ant.2020.12.001","journal-title":"Adv Neurotoxicology"},{"key":"1953_CR44","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1006\/rtph.2000.1441","volume":"33","author":"MG Soni","year":"2001","unstructured":"Soni MG, White SM, Flamm WG, Burdock GA (2001) Safety Evaluation of Dietary Aluminum. Regul Toxicol Pharmacol 33:66\u201379. https:\/\/doi.org\/10.1006\/rtph.2000.1441","journal-title":"Regul Toxicol Pharmacol"},{"key":"1953_CR45","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuro.2018.04.012","volume":"67","author":"Q Tang","year":"2018","unstructured":"Tang Q, Bai L, Zou Z et al (2018) Ferroptosis is newly characterised form of neuronal cell death in response to arsenite exposure. Neurotoxicology 67:27\u201336. https:\/\/doi.org\/10.1016\/j.neuro.2018.04.012","journal-title":"Neurotoxicology"},{"key":"1953_CR46","doi-asserted-by":"publisher","first-page":"100019","DOI":"10.1016\/j.dscb.2021.100019","volume":"3","author":"S Upadhayay","year":"2021","unstructured":"Upadhayay S, Mehan S (2021) Targeting Nrf2\/HO-1 antioxidant signalling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions. Brain Disord 3:100019. https:\/\/doi.org\/10.1016\/j.dscb.2021.100019","journal-title":"Brain Disord"},{"key":"1953_CR47","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-981-13-1370-7_3","volume-title":"Neurotoxicity of Aluminum","author":"L Wang","year":"2018","unstructured":"Wang L (2018) Entry and Deposit of Aluminum in the Brain. In: Niu Q (ed) Neurotoxicity of Aluminum. Springer, Singapore, pp 39\u201351"},{"key":"1953_CR48","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.18632\/aging.102234","volume":"11","author":"R Wang","year":"2019","unstructured":"Wang R, Liu L, Liu H et al (2019) Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. Aging 11:7021\u20137035. https:\/\/doi.org\/10.18632\/aging.102234","journal-title":"Aging"},{"key":"1953_CR49","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuro.2019.10.011","volume":"76","author":"S Wang","year":"2020","unstructured":"Wang S, Meng H, Shang N et al (2020) The Relationship between Plasma Al Levels and Multidomain Cognitive Performance among In-service Aluminum-exposed Workers at the SH Aluminum Factory in China: A Cross-sectional Study. Neurotoxicology 76:144\u2013152. https:\/\/doi.org\/10.1016\/j.neuro.2019.10.011","journal-title":"Neurotoxicology"},{"key":"1953_CR50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10495-023-01902-9","volume":"29","author":"Y Wang","year":"2024","unstructured":"Wang Y, Li H, He Q et al (2024) Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases. Apoptosis Int J Program Cell Death 29:3\u201321. https:\/\/doi.org\/10.1007\/s10495-023-01902-9","journal-title":"Apoptosis Int J Program Cell Death"},{"key":"1953_CR51","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3109\/10408444.2012.674101","volume":"42","author":"CC Willhite","year":"2012","unstructured":"Willhite CC, Ball GL, McLellan CJ (2012) Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water. Crit Rev Toxicol 42:358\u2013442. https:\/\/doi.org\/10.3109\/10408444.2012.674101","journal-title":"Crit Rev Toxicol"},{"key":"1953_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110181","volume":"119","author":"J Wongpun","year":"2023","unstructured":"Wongpun J, Chanmanee T, Tocharus J et al (2023) The potential effects of festidinol treatment against the NLRP3 inflammasome and pyroptosis in D-galactose and aluminum chloride\u2013induced Alzheimer\u2019s-like pathology in mouse brain. Int Immunopharmacol 119:110181. https:\/\/doi.org\/10.1016\/j.intimp.2023.110181","journal-title":"Int Immunopharmacol"},{"key":"1953_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2025.123480","volume":"473","author":"NV Zaitseva","year":"2025","unstructured":"Zaitseva NV, Zemlyanova \u041c\u0410, Gekht AB et al (2025) Neurotoxic effects of aluminum and manganese: from molecular to clinical effects. J Neurol Sci 473:123480. https:\/\/doi.org\/10.1016\/j.jns.2025.123480","journal-title":"J Neurol Sci"},{"key":"1953_CR55","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.tiv.2011.11.010","volume":"26","author":"K-W Zeng","year":"2012","unstructured":"Zeng K-W, Fu H, Liu G-X, Wang X-M (2012) Aluminum maltolate induces primary rat astrocyte apoptosis via overactivation of the class III PI3K\/Beclin 1-dependent autophagy signal. Toxicol Vitro 26:215\u2013220. https:\/\/doi.org\/10.1016\/j.tiv.2011.11.010","journal-title":"Toxicol Vitro"},{"key":"1953_CR56","doi-asserted-by":"publisher","first-page":"125179","DOI":"10.1016\/j.jhazmat.2021.125179","volume":"411","author":"H Zhang","year":"2021","unstructured":"Zhang H, Jiao W, Cui H et al (2021) Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis by activating IFN-\u03b3\/ASK1\/JNK signalling pathway in rats. J Hazard Mater 411:125179. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.125179","journal-title":"J Hazard Mater"},{"key":"1953_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129093","volume":"436","author":"H Zhang","year":"2022","unstructured":"Zhang H, Wang J, Ruan C et al (2022) Coexposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B\/NLRP3 signalling pathway. J Hazard Mater 436:129093. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.129093","journal-title":"J Hazard Mater"},{"key":"1953_CR58","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.chemosphere.2018.03.162","volume":"203","author":"H Zhang","year":"2018","unstructured":"Zhang H, Wang P, Yu H et al (2018) Aluminum trichloride-induced hippocampal inflammatory lesions are associated with IL-1\u03b2-activated IL-1 signalling pathway in developing rats. Chemosphere 203:170\u2013178. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.03.162","journal-title":"Chemosphere"},{"key":"1953_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.136942","volume":"715","author":"H Zhang","year":"2020","unstructured":"Zhang H, Wei M, Lu X et al (2020) Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1\u03b2\/JNK signalling pathway. Sci Total Environ 715:136942. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.136942","journal-title":"Sci Total Environ"},{"key":"1953_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115860","volume":"270","author":"J Zhang","year":"2024","unstructured":"Zhang J, Li X, Zhang Z et al (2024a) Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis. Ecotoxicol Environ Saf 270:115860. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115860","journal-title":"Ecotoxicol Environ Saf"},{"key":"1953_CR61","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3760\/cma.j.cn121094-20221103-00526","volume":"41","author":"JT Zhang","year":"2023","unstructured":"Zhang JT, Zhang ZR, Li XY et al (2023) [Hsp90 participates in the necroptosis of mouse neural cells induced by aluminum through the RIP1\/RIP3\/MLKL pathway]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Zhonghua Laodong Weisheng Zhiyebing Zazhi Chin. J Ind Hyg Occup Dis 41:881\u2013886. https:\/\/doi.org\/10.3760\/cma.j.cn121094-20221103-00526","journal-title":"J Ind Hyg Occup Dis"},{"key":"1953_CR62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bbi.2024.03.038","volume":"119","author":"X Zhang","year":"2024","unstructured":"Zhang X, Zhang Y, Wang B et al (2024b) Pyroptosis-mediator GSDMD promotes Parkinson\u2019s disease pathology via microglial activation and dopaminergic neuronal death. Brain Behav Immun 119:129\u2013145. https:\/\/doi.org\/10.1016\/j.bbi.2024.03.038","journal-title":"Brain Behav Immun"},{"key":"1953_CR63","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1007\/s11064-022-03653-6","volume":"47","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Feng Q, Li Y et al (2022) Aluminum Induced Necroptosis of PC12 Cells via TNFR1-RIP1\/RIP3 Signalling Pathway. Neurochem Res 47:3037\u20133050. https:\/\/doi.org\/10.1007\/s11064-022-03653-6","journal-title":"Neurochem Res"},{"key":"1953_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114373","volume":"249","author":"X Zhu","year":"2023","unstructured":"Zhu X, Hao W, Liu Z et al (2023) Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway. Ecotoxicol Environ Saf 249:114373. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114373","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01953-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01953-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01953-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:31:01Z","timestamp":1787819461000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01953-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1953"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01953-2","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"26 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No AI tool was used during the preparation of this paper.","order":1,"name":"Ethics","label":"Generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"193"}}