{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:07:20Z","timestamp":1789204040437,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-01985-8","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:59:19Z","timestamp":1789203559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice"],"prefix":"10.1007","volume":"41","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoran","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"1985_CR1","doi-asserted-by":"publisher","first-page":"1736969","DOI":"10.3389\/fnut.2026.1736969","volume":"13","author":"D Alkawamleh","year":"2026","unstructured":"Alkawamleh D, Madkour MI, Kalam F et al (2026) Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty [J]. Front Nutr 13:1736969","journal-title":"Front Nutr"},{"issue":"11","key":"1985_CR2","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1021\/acsptsci.4c00373","volume":"7","author":"Y Boondam","year":"2024","unstructured":"Boondam Y, Saefoong C, Niltup N et al (2024) The cognitive restoration effects of resveratrol: insight molecular through behavioral studies in various cognitive impairment models. ACS Pharmacol Transl Sci 7(11):3334\u20133357","journal-title":"ACS Pharmacol Transl Sci"},{"key":"1985_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010150","author":"Q Cai","year":"2020","unstructured":"Cai Q, Jeong YY (2020) Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative diseases. Cells. https:\/\/doi.org\/10.3390\/cells9010150","journal-title":"Cells"},{"issue":"11","key":"1985_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70657","volume":"31","author":"J Chen","year":"2025","unstructured":"Chen J, Liu B, Yao X et al (2025) AMPK\/SIRT1\/PGC-1\u03b1 signaling pathway: molecular mechanisms and targeted strategies from energy homeostasis regulation to disease therapy. CNS Neurosci Ther 31(11):e70657","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"1985_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13060","volume":"19","author":"Y Dang","year":"2020","unstructured":"Dang Y, An Y, He J et al (2020) Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 19(1):e13060","journal-title":"Aging Cell"},{"issue":"6","key":"1985_CR6","doi-asserted-by":"publisher","first-page":"7872","DOI":"10.18632\/aging.202805","volume":"13","author":"M Ferreira-Marques","year":"2021","unstructured":"Ferreira-Marques M, Carvalho A, Cavadas C et al (2021) PI3K\/AKT\/MTOR and ERK1\/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons. Aging (Albany NY) 13(6):7872\u20137882","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"1985_CR7","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","volume":"66","author":"D Garcia","year":"2017","unstructured":"Garcia D, Shaw RJ (2017) AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell 66(6):789\u2013800","journal-title":"Mol Cell"},{"issue":"9","key":"1985_CR8","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41580-018-0033-y","volume":"19","author":"M Hansen","year":"2018","unstructured":"Hansen M, Rubinsztein DC, Walker DW (2018) Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol 19(9):579\u2013593","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1985_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19(2):121\u2013135","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1985_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/jcsm.12653","volume":"12","author":"JH Kim","year":"2021","unstructured":"Kim JH, Park I, Shin HR et al (2021) The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance. J Cachexia Sarcopenia Muscle 12(1):177\u2013191","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"1985_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/15548627.2025.2581217","volume":"22","author":"J Lu","year":"2026","unstructured":"Lu J, Di Florio DN, Boya P et al (2026) Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders. Autophagy 22(1):10\u201352","journal-title":"Autophagy"},{"issue":"1","key":"1985_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev-cellbio-120420-094431","volume":"41","author":"N Malik","year":"2025","unstructured":"Malik N, Shaw RJ (2025) The AMPK Pathway: Molecular Rejuvenation of Metabolism and Mitochondria [J]. Annu Rev Cell Dev Biol 41(1):375\u2013402","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"5","key":"1985_CR13","doi-asserted-by":"publisher","first-page":"C1380","DOI":"10.1152\/ajpcell.01058.2024","volume":"329","author":"M Mandic","year":"2025","unstructured":"Mandic M, Misirkic Marjanovic M, Janjetovic K et al (2025) Multifaceted role of AMPK in autophagy: more than a simple trigger? Am J Physiol Cell Physiol 329(5):C1380\u2013C1397","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"1985_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112163","volume":"394","author":"DF Moreno","year":"2020","unstructured":"Moreno DF, Aldea M (2020) Proteostatic stress as a nodal hallmark of replicative aging. Exp Cell Res 394(2):112163","journal-title":"Exp Cell Res"},{"key":"1985_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/cells15090766","author":"S Niu","year":"2026","unstructured":"Niu S, Azzouz RS, Yan LJ (2026) Rodent models of D-galactose induction of accelerated aging: a platform for exploring kidney aging mechanisms and anti-kidney aging strategies. Cells. https:\/\/doi.org\/10.3390\/cells15090766","journal-title":"Cells"},{"issue":"1","key":"1985_CR16","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1038\/s41467-023-38401-z","volume":"14","author":"JM Park","year":"2023","unstructured":"Park JM, Lee DH, Kim DH (2023) Redefining the role of AMPK in autophagy and the energy stress response [J]. Nat Commun 14(1):2994","journal-title":"Nat Commun"},{"issue":"12","key":"1985_CR17","doi-asserted-by":"publisher","first-page":"16229","DOI":"10.1007\/s12035-025-05234-4","volume":"62","author":"S Patel","year":"2025","unstructured":"Patel S, Thornton A, Parmar MS (2025) Resveratrol\u2019s multifaceted potential in Alzheimer\u2019s disease: insights from preclinical and clinical evidence. Mol Neurobiol 62(12):16229\u201316260","journal-title":"Mol Neurobiol"},{"key":"1985_CR18","doi-asserted-by":"publisher","first-page":"101923","DOI":"10.1016\/j.mito.2024.101923","volume":"78","author":"Y Sahu","year":"2024","unstructured":"Sahu Y, Jamadade P, Ch Maharana K et al (2024) Role of mitochondrial homeostasis in D-galactose-induced cardiovascular ageing from bench to bedside [J]. Mitochondrion 78:101923","journal-title":"Mitochondrion"},{"key":"1985_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exger.2017.10.029","volume":"101","author":"T Shwe","year":"2018","unstructured":"Shwe T, Pratchayasakul W, Chattipakorn N et al (2018) Role of D-galactose-induced brain aging and its potential used for therapeutic interventions [J]. Exp Gerontol 101:13\u201336","journal-title":"Exp Gerontol"},{"issue":"1","key":"1985_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s42255-025-01442-3","volume":"8","author":"TKT Smith","year":"2026","unstructured":"Smith TKT, Townsend LK, Smiles WJ et al (2026) AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis. Nat Metab 8(1):27\u201351","journal-title":"Nat Metab"},{"issue":"6","key":"1985_CR21","doi-asserted-by":"publisher","first-page":"691","DOI":"10.14336\/AD.2017.0410","volume":"8","author":"J Wang","year":"2017","unstructured":"Wang J, Cao B, Zhao H et al (2017) Emerging roles of Ganoderma lucidum in anti-aging. Aging Dis 8(6):691\u2013707","journal-title":"Aging Dis"},{"issue":"Pt 4","key":"1985_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143033","volume":"309","author":"M Wang","year":"2025","unstructured":"Wang M, Wang Y, Wang X et al (2025) Lactoferrin ameliorates cognitive impairment in D-galactose-induced aging mice by regulating the PI3K\/Akt\/mTOR signaling pathway and the microbiome-gut-brain axis. Int J Biol Macromol 309(Pt 4):143033","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"1985_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev-neuro-112723-035356","volume":"48","author":"W Won","year":"2025","unstructured":"Won W, Bhalla M, Lee JH et al (2025) Astrocytes as key regulators of neural signaling in health and disease. Annu Rev Neurosci 48(1):251\u2013276","journal-title":"Annu Rev Neurosci"},{"key":"1985_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8291413","author":"Y Xu","year":"2020","unstructured":"Xu Y, Yuan H, Luo Y et al (2020) Ganoderic acid D protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK\/NRF2 signaling pathway. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2020\/8291413","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"1985_CR25","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/s42255-022-00640-7","volume":"4","author":"CS Zhang","year":"2022","unstructured":"Zhang CS, Li M, Wang Y et al (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab 4(10):1369\u20131401","journal-title":"Nat Metab"},{"issue":"1","key":"1985_CR27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41392-025-02493-4","volume":"10","author":"H Zhang","year":"2025","unstructured":"Zhang H, Xiao X, Pan Z et al (2025) mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics [J]. Signal Transduct Target Ther 10(1):428","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1985_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41531-025-01099-5","volume":"11","author":"S Zhang","year":"2025","unstructured":"Zhang S, Wan G, Qiu Y et al (2025) Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson\u2019s disease [J]. NPJ Parkinsons Dis 11(1):237","journal-title":"NPJ Parkinsons Dis"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01985-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-01985-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-01985-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:59:20Z","timestamp":1789203560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11011-026-01985-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1985"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-01985-8","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"7 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"219"}}