{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:41:54Z","timestamp":1792748514698,"version":"4.5.0"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"DOI":"10.1007\/s11011-026-02004-6","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:00:13Z","timestamp":1792742413000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Dyshomeostasis, neuroinflammation, and glymphatic clearance deficits as convergent drivers of Alzheimer\u2019s disease: an exposome-based conceptual framework for prevention"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-8549","authenticated-orcid":false,"given":"Ahmed M.","family":"Abdelaziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M.","family":"Eladawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2004_CR1","doi-asserted-by":"publisher","first-page":"118381","DOI":"10.1016\/J.BCP.2026.118381","volume":"254","author":"AM Abdelaziz","year":"2026","unstructured":"Abdelaziz AM, Eladawy RM (2026) Immunopharmacological reprogramming of innate immune memory in Alzheimer\u2019s disease: From microglial priming to therapeutic resilience. Biochem Pharmacol 254:118381. https:\/\/doi.org\/10.1016\/J.BCP.2026.118381","journal-title":"Biochem Pharmacol"},{"key":"2004_CR2","doi-asserted-by":"publisher","first-page":"110777","DOI":"10.1016\/J.CLIM.2026.110777","volume":"288","author":"AM Abdelaziz","year":"2026","unstructured":"Abdelaziz AM, Eltyar FS (2026) Clinical immunology lessons from failed \u03b1-Synuclein and Tau immunotherapies: A roadmap for combination strategies in Alzheimer\u2019s disease. Clin Immunol 288:110777. https:\/\/doi.org\/10.1016\/J.CLIM.2026.110777","journal-title":"Clin Immunol"},{"issue":"2 76","key":"2004_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/S12031-026-02531-Y","volume":"76","author":"AM Abdelaziz","year":"2026","unstructured":"Abdelaziz AM, Shokr MM, Fathy MK, Fawzy MN (2026) Dysfunction of the CD38-Miro1 axis disrupts astrocyte-neuron mitochondrial transfer in Alzheimer\u2019s disease: Mechanisms and therapeutic restoration. J Mol Neurosci 2026 76(2 76):89\u2013. https:\/\/doi.org\/10.1007\/S12031-026-02531-Y","journal-title":"J Mol Neurosci 2026"},{"key":"2004_CR4","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00125-019-05014-5","volume":"62","author":"N Akbar","year":"2019","unstructured":"Akbar N, Azzimato V, Choudhury RP, Aouadi M (2019) Extracellular vesicles in metabolic disease. Diabetologia 62:2179\u20132187","journal-title":"Diabetologia"},{"key":"2004_CR5","doi-asserted-by":"publisher","unstructured":"Alanazi M, Al-Kuraishy HM, Albuhadily AK et al (2025) The protective effect of amylin in type 2 diabetes: Yes or no. Eur J Pharmacol 996. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177593","DOI":"10.1016\/j.ejphar.2025.177593"},{"key":"2004_CR6","doi-asserted-by":"publisher","first-page":"9780067","DOI":"10.1155\/2022\/9780067","volume":"2022","author":"P Alexander","year":"2022","unstructured":"Alexander P, Visagan S, Jawhar S et al (2022) Antiplatelets and vascular dementia: A systematic review. J Aging Res 2022:9780067","journal-title":"J Aging Res"},{"key":"2004_CR7","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3390\/nu17040722","volume":"17","author":"SM Aliberti","year":"2025","unstructured":"Aliberti SM, Capunzo M (2025) The power of environment: A comprehensive review of the exposome\u2019s role in healthy aging, longevity, and preventive medicine\u2014lessons from blue zones and cilento. Nutrients 17:722","journal-title":"Nutrients"},{"key":"2004_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/JPM15090437","volume":"15","author":"AE Alkhalifa","year":"2025","unstructured":"Alkhalifa AE, Al Mokhlf A, Ali H et al (2025) Anti-Amyloid Monoclonal Antibodies for Alzheimer\u2019s Disease: Evidence, ARIA Risk, and Precision Patient Selection. J Pers Med 15:437. https:\/\/doi.org\/10.3390\/JPM15090437","journal-title":"J Pers Med"},{"key":"2004_CR9","doi-asserted-by":"publisher","first-page":"103639","DOI":"10.1016\/j.jpet.2025.103639","volume":"392","author":"NH Almohmadi","year":"2025","unstructured":"Almohmadi NH, Al-Kuraishy HM, Albuhadily AK et al (2025) Alzheimer disease: Amyloid peptide controversies and challenges of anti-A\u03b2 immunotherapy. J Pharmacol Exp Ther 392:103639. https:\/\/doi.org\/10.1016\/j.jpet.2025.103639","journal-title":"J Pharmacol Exp Ther"},{"key":"2004_CR10","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1007\/s10787-026-02281-8","volume":"34","author":"MO Alotaibi","year":"2026","unstructured":"Alotaibi MO, Al-kuraishy HM, Fahad EH et al (2026) Targeting inflammaging in Alzheimer\u2019s disease: Molecular pathways and emerging pharmacotherapies. Inflammopharmacology 34:4445\u20134461. https:\/\/doi.org\/10.1007\/s10787-026-02281-8","journal-title":"Inflammopharmacology"},{"key":"2004_CR11","doi-asserted-by":"publisher","first-page":"156983","DOI":"10.1016\/j.cyto.2025.156983","volume":"193","author":"SM Alshahrani","year":"2025","unstructured":"Alshahrani SM, Al-Kuraishy HM, Albuhadily AK et al (2025) GDF15 upregulation in Parkinson\u2019s disease: Compensatory mechanisms and causal insights. Cytokine 193:156983. https:\/\/doi.org\/10.1016\/j.cyto.2025.156983","journal-title":"Cytokine"},{"key":"2004_CR12","doi-asserted-by":"publisher","unstructured":"Alshammari F, Keil SA, Wilcox ME (2026) Sleep fragmentation, impaired glymphatic clearance, and long-term cognitive impairment after critical illness. Crit care Sci 38. https:\/\/doi.org\/10.62675\/2965-2774.20260042","DOI":"10.62675\/2965-2774.20260042"},{"key":"2004_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/biomedicines14010116","volume":"14","author":"B Alves","year":"2026","unstructured":"Alves B, Tavares I, Pozza DH (2026) Biomarkers and breakdowns: Neuroinflammatory drivers linking sleep disorders and chronic pain. Biomedicines 14:116","journal-title":"Biomedicines"},{"key":"2004_CR14","doi-asserted-by":"publisher","unstructured":"Amorim P, Hayashide L, de Leocadio S et al (2026) VE, Astrocyte Senescence Disrupts the Extracellular Mitochondrial Compartment and Compromises Bioenergetic Support to Human Neurons. Antioxidants 2026, Vol 15, Page 1127 15:1127. https:\/\/doi.org\/10.3390\/ANTIOX15091127","DOI":"10.3390\/ANTIOX15091127"},{"key":"2004_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/S13668-026-00743-7","volume":"15","author":"A Atar","year":"2026","unstructured":"Atar A, \u015eahin An\u0131lgan \u0130N (2026) Insulin resistance as a shared pathophysiological driver in neurological disorders: A Narrative Review. Curr Nutr Rep 15:18. https:\/\/doi.org\/10.1007\/S13668-026-00743-7","journal-title":"Curr Nutr Rep"},{"key":"2004_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s44323-025-00024-6","volume":"2","author":"K Begemann","year":"2025","unstructured":"Begemann K, Rawashdeh O, Olejniczak I et al (2025) Endocrine regulation of circadian rhythms. npj Biol Timing Sleep 2:10","journal-title":"npj Biol Timing Sleep"},{"key":"2004_CR17","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3233\/JAD-161192","volume":"59","author":"P Bharadwaj","year":"2017","unstructured":"Bharadwaj P, Wijesekara N, Liyanapathirana M et al (2017) The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-\u03b2, Amylin, and Tau Proteins. J Alzheimer\u2019s Disease 59:421\u2013432. https:\/\/doi.org\/10.3233\/JAD-161192","journal-title":"J Alzheimer\u2019s Disease"},{"key":"2004_CR18","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","volume":"1863","author":"JS Bhatti","year":"2017","unstructured":"Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders\u2014A step towards mitochondria based therapeutic strategies. Biochimica et biophysica acta (BBA)-Molecular. basis disease 1863:1066\u20131077","journal-title":"basis disease"},{"key":"2004_CR19","doi-asserted-by":"crossref","unstructured":"Bird SR, Hawley JA (2017) Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc Med 2","DOI":"10.1136\/bmjsem-2016-000143"},{"key":"2004_CR20","doi-asserted-by":"publisher","unstructured":"Blew CO, Duggan MR, Tsitsipatis D et al (2026) Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling. Sci Adv 12. https:\/\/doi.org\/10.1126\/SCIADV.AEC7614","DOI":"10.1126\/SCIADV.AEC7614"},{"key":"2004_CR21","doi-asserted-by":"publisher","first-page":"111575","DOI":"10.1016\/j.mad.2021.111575","volume":"200","author":"Y Blinkouskaya","year":"2021","unstructured":"Blinkouskaya Y, Ca\u00e7oilo A, Gollamudi T et al (2021) Brain aging mechanisms with mechanical manifestations. Mech Ageing Dev 200:111575","journal-title":"Mech Ageing Dev"},{"key":"2004_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/B978-0-12-407704-1.00005-1","volume":"301","author":"R Bravo","year":"2013","unstructured":"Bravo R, Parra V, Gatica D et al (2013) Endoplasmic reticulum and the unfolded protein response: Dynamics and metabolic integration. Int Rev Cell Mol Biol 301:215\u2013290","journal-title":"Int Rev Cell Mol Biol"},{"key":"2004_CR23","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s00125-019-05084-5","volume":"63","author":"A Brouwer","year":"2020","unstructured":"Brouwer A, Asare Bediako I, Paszkiewicz RL et al (2020) Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs. Diabetologia 63:875\u2013884","journal-title":"Diabetologia"},{"key":"2004_CR24","doi-asserted-by":"publisher","first-page":"856376","DOI":"10.3389\/fimmu.2022.856376","volume":"13","author":"Y Cai","year":"2022","unstructured":"Cai Y, Liu J, Wang B et al (2022) Microglia in the neuroinflammatory pathogenesis of Alzheimer\u2019s disease and related therapeutic targets. Front Immunol 13:856376","journal-title":"Front Immunol"},{"key":"2004_CR25","doi-asserted-by":"crossref","unstructured":"Cankar N, Beschorner N, Tsopanidou A et al (2024) Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-\u03b2 accumulation in a murine Alzheimer model. Cell Rep 43","DOI":"10.1016\/j.celrep.2024.114977"},{"key":"2004_CR26","doi-asserted-by":"publisher","first-page":"644747","DOI":"10.3389\/fmolb.2021.644747","volume":"8","author":"B Carter","year":"2021","unstructured":"Carter B, Justin HS, Gulick D, Gamsby JJ (2021) The molecular clock and neurodegenerative disease: A stressful time. Front Mol Biosci 8:644747","journal-title":"Front Mol Biosci"},{"key":"2004_CR27","doi-asserted-by":"publisher","first-page":"e71342","DOI":"10.1002\/alz.71342","volume":"22","author":"C Cavaill\u00e8s","year":"2026","unstructured":"Cavaill\u00e8s C, Carnethon MR, Knutson KL et al (2026) Midlife sleep characteristics and Alzheimer\u2019s disease biomarkers 20 years later. Alzheimer\u2019s Dement 22:e71342","journal-title":"Alzheimer\u2019s Dement"},{"key":"2004_CR28","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.3390\/nu17121964","volume":"17","author":"J Charbit","year":"2025","unstructured":"Charbit J, Vidal J-S, Hanon O (2025) Effects of dietary interventions on cognitive outcomes. Nutrients 17:1964","journal-title":"Nutrients"},{"key":"2004_CR29","doi-asserted-by":"publisher","unstructured":"Chauhan A, Devi R, Singh S et al (2026) Current and emerging therapeutic approaches in Alzheimer\u2019s disease. Discover Neuroscience 2026 21:1 21:57-. https:\/\/doi.org\/10.1186\/S13064-026-00290-5","DOI":"10.1186\/S13064-026-00290-5"},{"key":"2004_CR32","doi-asserted-by":"publisher","first-page":"1258640","DOI":"10.3389\/fnagi.2023.1258640","volume":"15","author":"Y Chen","year":"2023","unstructured":"Chen Y, He Y, Han J et al (2023) Blood-brain barrier dysfunction and Alzheimer\u2019s disease: Associations, pathogenic mechanisms, and therapeutic potential. Front Aging Neurosci 15:1258640","journal-title":"Front Aging Neurosci"},{"key":"2004_CR30","doi-asserted-by":"publisher","first-page":"117084","DOI":"10.1016\/j.biopha.2024.117084","volume":"178","author":"S Chen","year":"2024","unstructured":"Chen S, Li Q, Shi H et al (2024a) New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases. Biomed Pharmacother 178:117084","journal-title":"Biomed Pharmacother"},{"key":"2004_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12987-024-00557-1","volume":"21","author":"T Chen","year":"2024","unstructured":"Chen T, Dai Y, Hu C et al (2024b) Cellular and molecular mechanisms of the blood\u2013brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS 21:60","journal-title":"Fluids Barriers CNS"},{"key":"2004_CR33","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.3390\/jcm15051884","volume":"15","author":"RC Christodoulou","year":"2026","unstructured":"Christodoulou RC, Eller D, Papageorgiou PS et al (2026) Metabolic dysfunction in Alzheimer\u2019s disease: Brain glucose hypometabolism as an early precursor to amyloid and tau pathology. J Clin Med 15:1884","journal-title":"J Clin Med"},{"key":"2004_CR34","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/BIOMEDICINES14020394","volume":"14","author":"J Cielecka","year":"2026","unstructured":"Cielecka J, Szkamruk Z, Wal\u0119dziak M, R\u00f3\u017ca\u0144ska-Wal\u0119dziak A (2026) From metabolism to mind: The cardio\u2013metabolic\u2013brain axis and the role of insulin resistance\u2014A. Rev Biomedicines 2026 14:394. https:\/\/doi.org\/10.3390\/BIOMEDICINES14020394","journal-title":"Rev Biomedicines 2026"},{"key":"2004_CR35","first-page":"140","volume":"9","author":"GM Cole","year":"2010","unstructured":"Cole GM, Frautschy SA (2010) Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer\u2019s disease. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS &. Neurol Disorders) 9:140\u2013148","journal-title":"Neurol Disorders)"},{"key":"2004_CR36","doi-asserted-by":"crossref","unstructured":"Colon ZA, Chan SC, Maguire-Zeiss KA (2025) Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders. bioRxiv","DOI":"10.1101\/2025.09.10.675190"},{"key":"2004_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-026-68374-8","volume":"17","author":"P Dagum","year":"2026","unstructured":"Dagum P, Elbert DL, Giovangrandi L et al (2026) The glymphatic system clears amyloid beta and tau from brain to plasma in humans. Nat Commun 2026 17:1. https:\/\/doi.org\/10.1038\/s41467-026-68374-8","journal-title":"Nat Commun 2026"},{"key":"2004_CR38","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/S10787-025-01704-2","volume":"33","author":"M Dahiya","year":"2025","unstructured":"Dahiya M, Yadav M, Goyal C, Kumar A (2025) Insulin resistance in Alzheimer\u2019s disease: signalling mechanisms and therapeutics strategies. Inflammopharmacology 33:1817\u20131831. https:\/\/doi.org\/10.1007\/S10787-025-01704-2","journal-title":"Inflammopharmacology"},{"key":"2004_CR39","doi-asserted-by":"publisher","unstructured":"de Vries LE, Huitinga I, Kessels HW et al (2024) The concept of resilience to Alzheimer\u2019s Disease: Current definitions and cellular and molecular mechanisms. Molecular Neurodegeneration 2024 19:1 19:33-. https:\/\/doi.org\/10.1186\/S13024-024-00719-7","DOI":"10.1186\/S13024-024-00719-7"},{"key":"2004_CR40","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1093\/aje\/kwv325","volume":"184","author":"DG DeBord","year":"2016","unstructured":"DeBord DG, Carre\u00f3n T, Lentz TJ et al (2016) Use of the exposome in the practice of epidemiology: A primer on-omic technologies. Am J Epidemiol 184:302\u2013314","journal-title":"Am J Epidemiol"},{"key":"2004_CR41","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.3390\/ijerph19063534","volume":"19","author":"S Deguen","year":"2022","unstructured":"Deguen S, Amuzu M, Simoncic V, Kihal-Talantikite W (2022) Exposome and social vulnerability: an overview of the literature review. Int J Environ Res Public Health 19:3534","journal-title":"Int J Environ Res Public Health"},{"key":"2004_CR42","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00043.2008","volume":"90","author":"JA Dempsey","year":"2010","unstructured":"Dempsey JA, Veasey SC, Morgan BJ, O\u2019Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90:47\u2013112","journal-title":"Physiol Rev"},{"key":"2004_CR43","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/ana.25668","volume":"87","author":"F Despa","year":"2020","unstructured":"Despa F, Goldstein LB, Biessels GJ (2020) Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease. Ann Neurol 87:486. https:\/\/doi.org\/10.1002\/ana.25668","journal-title":"Ann Neurol"},{"key":"2004_CR44","doi-asserted-by":"publisher","unstructured":"Ding J, Zhao C, Hao X, Jiao H (2025) Glymphatic and meningeal lymphatic dysfunction in Alzheimer\u2019s disease: Mechanisms and therapeutic perspectives. Alzheimers Dement 21. https:\/\/doi.org\/10.1002\/ALZ.70709","DOI":"10.1002\/ALZ.70709"},{"key":"2004_CR45","first-page":"1843","volume":"15","author":"M Dolatshahi","year":"2024","unstructured":"Dolatshahi M, Commean PK, Rahmani F et al (2024) Alzheimer disease pathology and neurodegeneration in midlife obesity: A pilot study. Aging Dis 15:1843","journal-title":"Aging Dis"},{"key":"2004_CR46","doi-asserted-by":"crossref","unstructured":"Edwards BA, O\u2019Driscoll DM, Ali A et al (2010) Aging and sleep: physiology and pathophysiology. Seminars in respiratory and critical care medicine. \u00a9 Thieme Medical, pp 618\u2013633","DOI":"10.1055\/s-0030-1265902"},{"key":"2004_CR47","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1093\/cercor\/bhac491","volume":"33","author":"B Ficek-Tani","year":"2023","unstructured":"Ficek-Tani B, Horien C, Ju S et al (2023) Sex differences in default mode network connectivity in healthy aging adults. Cereb Cortex 33:6139\u20136151","journal-title":"Cereb Cortex"},{"key":"2004_CR48","doi-asserted-by":"publisher","first-page":"e2025E001","DOI":"10.1590\/1980-5764-dn-2025-e001","volume":"19","author":"OV Forlenza","year":"2025","unstructured":"Forlenza OV, Barbosa BJAP (2025) What are the reasons for the repeated failures of clinical trials with anti-amyloid drugs for AD treatment? Dement Neuropsychol 19:e2025E001","journal-title":"Dement Neuropsychol"},{"key":"2004_CR49","doi-asserted-by":"publisher","first-page":"722523","DOI":"10.3389\/fnint.2021.722523","volume":"15","author":"JE Garc\u00eda-Aviles","year":"2021","unstructured":"Garc\u00eda-Aviles JE, M\u00e9ndez-Hern\u00e1ndez R, Guzm\u00e1n-Ruiz MA et al (2021) Metabolic disturbances induced by sleep restriction as potential triggers for Alzheimer\u2019s disease. Front Integr Neurosci 15:722523","journal-title":"Front Integr Neurosci"},{"key":"2004_CR50","doi-asserted-by":"publisher","first-page":"e108874","DOI":"10.1002\/ALZ70861_108874","volume":"21","author":"GM Garofalo","year":"2025","unstructured":"Garofalo GM, Reddy JS, Heckman MG et al (2025) Investigating the role of the exposome on neuropathology and biochemical phenotypes in Alzheimer\u2019s disease. Alzheimer\u2019s Dement 21:e108874. https:\/\/doi.org\/10.1002\/ALZ70861_108874","journal-title":"Alzheimer\u2019s Dement"},{"key":"2004_CR51","doi-asserted-by":"publisher","unstructured":"Gawlak-Socka S, Kowalczyk E, Wiktorowska-Owczarek A (2026) Unfolded protein response at the crossroads: Integrating endoplasmic reticulum stress with cellular stress networks. Int J Mol Sci 2026 27 Page 1986 27:1986. https:\/\/doi.org\/10.3390\/IJMS27041986","DOI":"10.3390\/IJMS27041986"},{"key":"2004_CR52","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11357-023-00947-7","volume":"46","author":"S Giunta","year":"2024","unstructured":"Giunta S, Xia S, Pelliccioni G, Olivieri F (2024) Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies. Geroscience 46:113\u2013127","journal-title":"Geroscience"},{"key":"2004_CR53","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3390\/cimb47050357","volume":"47","author":"EMM Gkrinia","year":"2025","unstructured":"Gkrinia EMM, Belan\u010di\u0107 A (2025) The mechanisms of chronic inflammation in obesity and potential therapeutic strategies: A narrative review. Curr Issues Mol Biol 47:357","journal-title":"Curr Issues Mol Biol"},{"key":"2004_CR54","doi-asserted-by":"publisher","first-page":"6613385","DOI":"10.1155\/2021\/6613385","volume":"2021","author":"E G\u00f3mez-Apo","year":"2021","unstructured":"G\u00f3mez-Apo E, Mondrag\u00f3n-Maya A, Ferrari-D\u00edaz M, Silva-Pereyra J (2021) Structural brain changes associated with overweight and obesity. J Obes 2021:6613385","journal-title":"J Obes"},{"key":"2004_CR55","doi-asserted-by":"crossref","unstructured":"Gomez-Arboledas A, Acharya MM, Tenner AJ (2021) The role of complement in synaptic pruning and neurodegeneration. Immunotargets Ther 373\u2013386","DOI":"10.2147\/ITT.S305420"},{"key":"2004_CR56","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3390\/ijerph22060815","volume":"22","author":"J Gong","year":"2025","unstructured":"Gong J, Zaninotto P (2025) Integrating exposome into lifecourse understanding of cognitive ageing and dementia: Current evidence, methodological challenges, and future directions. Int J Environ Res Public Health 22:815","journal-title":"Int J Environ Res Public Health"},{"key":"2004_CR57","first-page":"568","volume":"374","author":"MA Grandner","year":"2021","unstructured":"Grandner MA, Fernandez F-X (2021) The translational neuroscience of sleep: A contextual framework. Sci (1979) 374:568\u2013573","journal-title":"Sci (1979)"},{"key":"2004_CR58","doi-asserted-by":"publisher","first-page":"549567","DOI":"10.3389\/fnins.2020.00894","volume":"14","author":"TRF Green","year":"2020","unstructured":"Green TRF, Ortiz JB, Wonnacott S et al (2020) The bidirectional relationship between sleep and inflammation links traumatic brain injury and Alzheimer\u2019s disease. Front Neurosci 14:549567","journal-title":"Front Neurosci"},{"key":"2004_CR59","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1017\/S1355617708080302","volume":"14","author":"E Grober","year":"2008","unstructured":"Grober E, Hall CB, Lipton RB et al (2008) Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer\u2019s disease. J Int Neuropsychol Soc 14:266\u2013278","journal-title":"J Int Neuropsychol Soc"},{"key":"2004_CR60","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","volume":"10","author":"F Guan","year":"2025","unstructured":"Guan F, Wang R, Yi Z et al (2025) Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets. Signal Transduct Target Ther 10:93","journal-title":"Signal Transduct Target Ther"},{"key":"2004_CR61","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.201709069","volume":"217","author":"DV Hansen","year":"2018","unstructured":"Hansen DV, Hanson JE, Sheng M (2018) Microglia in Alzheimer\u2019s disease. J Cell Biol 217:459\u2013472","journal-title":"J Cell Biol"},{"key":"2004_CR62","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11571-025-10298-y","volume":"19","author":"Z He","year":"2025","unstructured":"He Z, Sun J (2025) Clearance mechanisms of the glymphatic\/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment. Cogn Neurodyn 19:111","journal-title":"Cogn Neurodyn"},{"key":"2004_CR63","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00125-024-06104-9","volume":"67","author":"M Heni","year":"2024","unstructured":"Heni M (2024) The insulin resistant brain: impact on whole-body metabolism and body fat distribution. Diabetologia 67:1181\u20131191","journal-title":"Diabetologia"},{"key":"2004_CR64","doi-asserted-by":"publisher","first-page":"1709983","DOI":"10.3389\/fmed.2025.1709983","volume":"12","author":"X Hou","year":"2026","unstructured":"Hou X, Wei Y, Wang Y, Wang L (2026) Mendelian randomization studies on the causal relationship between insomnia and disease. Front Med (Lausanne) 12:1709983","journal-title":"Front Med (Lausanne)"},{"key":"2004_CR65","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2174\/0115672050364292250113063513","volume":"22","author":"MS Hussain","year":"2025","unstructured":"Hussain MS, Khan Y, Fatima R et al (2025) Microglial modulation in Alzheimer\u2019s disease: Central players in neuroinflammation and pathogenesis. Curr Alzheimer Res 22:56\u201382. https:\/\/doi.org\/10.2174\/0115672050364292250113063513","journal-title":"Curr Alzheimer Res"},{"key":"2004_CR66","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1080\/23328940.2022.2109932","volume":"10","author":"MR Irwin","year":"2023","unstructured":"Irwin MR (2023) Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature. Temperature 10:198\u2013234","journal-title":"Temperature"},{"key":"2004_CR67","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/antiox11112167","volume":"11","author":"MC Jurc\u0103u","year":"2022","unstructured":"Jurc\u0103u MC, Andronie-Cioara FL, Jurc\u0103u A et al (2022) The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer\u2019s disease: therapeutic implications and future perspectives. Antioxidants 11:2167","journal-title":"Antioxidants"},{"key":"2004_CR68","doi-asserted-by":"publisher","first-page":"osac002","DOI":"10.1093\/exposome\/osac002","volume":"2","author":"V Kalia","year":"2022","unstructured":"Kalia V, Belsky DW, Baccarelli AA, Miller GW (2022) An exposomic framework to uncover environmental drivers of aging. Exposome 2:osac002","journal-title":"Exposome"},{"key":"2004_CR69","doi-asserted-by":"publisher","unstructured":"Keil SA, Jansson D, Braun M, Iliff JJ (2025) Glymphatic dysfunction in Alzheimer\u2019s disease: A critical appraisal. Science 389. https:\/\/doi.org\/10.1126\/SCIENCE.ADV8269","DOI":"10.1126\/SCIENCE.ADV8269"},{"key":"2004_CR70","doi-asserted-by":"publisher","first-page":"e2017009","DOI":"10.5620\/eht.e2017009","volume":"32","author":"K-N Kim","year":"2017","unstructured":"Kim K-N, Hong Y-C (2017) The exposome and the future of epidemiology: A vision and prospect. Environ Health Toxicol 32:e2017009","journal-title":"Environ Health Toxicol"},{"key":"2004_CR71","first-page":"575","volume":"4","author":"JW Kinney","year":"2018","unstructured":"Kinney JW, Bemiller SM, Murtishaw AS et al (2018) Inflammation as a central mechanism in Alzheimer\u2019s disease. Alzheimer\u2019s Dementia: Translational Res Clin Interventions 4:575\u2013590","journal-title":"Alzheimer\u2019s Dementia: Translational Res Clin Interventions"},{"key":"2004_CR72","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.jalz.2012.09.012","volume":"9","author":"M Kivipelto","year":"2013","unstructured":"Kivipelto M, Solomon A, Ahtiluoto S et al (2013) The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimer\u2019s Dement 9:657\u2013665","journal-title":"Alzheimer\u2019s Dement"},{"key":"2004_CR73","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1196\/annals.1417.033","volume":"1129","author":"KL Knutson","year":"2008","unstructured":"Knutson KL, Van Cauter E (2008) Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci 1129:287\u2013304","journal-title":"Ann N Y Acad Sci"},{"key":"2004_CR74","doi-asserted-by":"publisher","unstructured":"kodi T, Nandakumar K, Kishore A (2026) AMPK\u2013NLRP3 Inflammasome crosstalk: Structural insights, molecular mechanisms, and therapeutic implications for inflammation and neuroinflammation. Molecular Neurobiology 2026 63:1 63:684-. https:\/\/doi.org\/10.1007\/S12035-026-05932-7","DOI":"10.1007\/S12035-026-05932-7"},{"key":"2004_CR75","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.ogc.2018.07.008","volume":"45","author":"HM Kravitz","year":"2018","unstructured":"Kravitz HM, Kazlauskaite R, Joffe H (2018) Sleep, health, and metabolism in midlife women and menopause: food for thought. Obstet Gynecol Clin 45:679\u2013694","journal-title":"Obstet Gynecol Clin"},{"key":"2004_CR76","doi-asserted-by":"publisher","first-page":"003685042311895","DOI":"10.1177\/00368504231189536","volume":"106","author":"S Kureshi","year":"2023","unstructured":"Kureshi S, Stowe C, Francis J, Djalilian H (2023) Circadian therapy interventions for glymphatic dysfunction in concussions injuries: A narrative review. Sci Prog 106:00368504231189536","journal-title":"Sci Prog"},{"key":"2004_CR77","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3390\/biom13030453","volume":"13","author":"M Kurkinen","year":"2023","unstructured":"Kurkinen M, Fu\u0142ek M, Fu\u0142ek K et al (2023) The amyloid cascade hypothesis in Alzheimer\u2019s disease: should we change our thinking? Biomolecules 13:453","journal-title":"Biomolecules"},{"key":"2004_CR78","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149:274\u2013293","journal-title":"Cell"},{"key":"2004_CR79","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/acn3.51779","volume":"10","author":"Y Lee","year":"2023","unstructured":"Lee Y, Yoon S, Yoon SH et al (2023) Air pollution is associated with faster cognitive decline in Alzheimer\u2019s disease. Ann Clin Transl Neurol 10:964\u2013973","journal-title":"Ann Clin Transl Neurol"},{"key":"2004_CR80","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1038\/S41591-026-04302-Z","volume":"32","author":"A Legaz","year":"2026","unstructured":"Legaz A, Moguilner S, Barttfeld P et al (2026) The exposome of brain aging across 34 countries. Nat Med 32:1838\u20131851. https:\/\/doi.org\/10.1038\/S41591-026-04302-Z","journal-title":"Nat Med"},{"key":"2004_CR81","doi-asserted-by":"publisher","first-page":"11013","DOI":"10.3390\/ijms262211013","volume":"26","author":"K Lemus-Roldan","year":"2025","unstructured":"Lemus-Roldan K, Castorena Torres F, Le\u00f3n Rojas D, Rodr\u00edguez-de-Ita J (2025) From early adversity to neurodegeneration: Stress biomarkers as predictive signals for lifespan brain health. Int J Mol Sci 26:11013","journal-title":"Int J Mol Sci"},{"issue":"1 10","key":"2004_CR82","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/S13195-018-0422-7","volume":"10","author":"SL Lesuis","year":"2018","unstructured":"Lesuis SL, Hoeijmakers L, Korosi A et al (2018) Vulnerability and resilience to Alzheimer\u2019s disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer\u2019s Res Therapy 2018 10(1 10):95\u2013. https:\/\/doi.org\/10.1186\/S13195-018-0422-7","journal-title":"Alzheimer\u2019s Res Therapy 2018"},{"key":"2004_CR83","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li X, Li C, Zhang W et al (2023) Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther 8:239","journal-title":"Signal Transduct Target Ther"},{"key":"2004_CR84","doi-asserted-by":"publisher","first-page":"878987","DOI":"10.3389\/fncel.2022.878987","volume":"16","author":"MN Lima","year":"2022","unstructured":"Lima MN, Barbosa-Silva MC, Maron-Gutierrez T (2022) Microglial priming in infections and its risk to neurodegenerative diseases. Front Cell Neurosci 16:878987","journal-title":"Front Cell Neurosci"},{"key":"2004_CR85","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","volume":"7","author":"K Lingappan","year":"2018","unstructured":"Lingappan K (2018) NF-\u03baB in oxidative stress. Curr Opin Toxicol 7:81\u201386","journal-title":"Curr Opin Toxicol"},{"key":"2004_CR86","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","volume":"9","author":"C-C Liu","year":"2013","unstructured":"Liu C-C, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy. Nat Rev Neurol 9:106\u2013118","journal-title":"Nat Rev Neurol"},{"key":"2004_CR87","first-page":"1","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Ther 2:1\u20139","journal-title":"Signal Transduct Target Ther"},{"key":"2004_CR88","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12974-020-01905-2","volume":"17","author":"X Liu","year":"2020","unstructured":"Liu X, Ma Y, Ouyang R et al (2020) The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome. J Neuroinflammation 17:229","journal-title":"J Neuroinflammation"},{"key":"2004_CR89","doi-asserted-by":"publisher","first-page":"1664865","DOI":"10.3389\/fcvm.2025.1664865","volume":"12","author":"Z Liu","year":"2026","unstructured":"Liu Z, Sun H, Liu H et al (2026) Temporal relationship between inflammation and metabolic disorders and its influence on atherosclerotic cardiovascular disease. Front Cardiovasc Med 12:1664865","journal-title":"Front Cardiovasc Med"},{"key":"2004_CR90","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.3390\/ijms26157149","volume":"26","author":"F Ma","year":"2025","unstructured":"Ma F, Yu W (2025) The roles of lactate and lactylation in diseases related to mitochondrial dysfunction. Int J Mol Sci 26:7149","journal-title":"Int J Mol Sci"},{"key":"2004_CR91","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1016\/j.apsb.2025.04.011","volume":"15","author":"K Madamanchi","year":"2025","unstructured":"Madamanchi K, Zhang J, Melkani GC (2025) Linkage of circadian rhythm disruptions with Alzheimer\u2019s disease and therapeutic interventions. Acta Pharm Sin B 15:2945\u20132965","journal-title":"Acta Pharm Sin B"},{"issue":"2","key":"2004_CR92","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/S12031-026-02518-9","volume":"76","author":"E Manni","year":"2026","unstructured":"Manni E, Al-Kuraishy HM, Eisawy R et al (2026) Reimagining GSK-3\u03b2 therapeutics in Alzheimer\u2019s disease: From inhibition to activity normalization and targeted degradation. J Mol Neurosci 2026 76(2):66. https:\/\/doi.org\/10.1007\/S12031-026-02518-9","journal-title":"J Mol Neurosci 2026"},{"key":"2004_CR93","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s11011-024-01393-w","volume":"39","author":"NE Mbiydzenyuy","year":"2024","unstructured":"Mbiydzenyuy NE, Qulu L-A (2024) Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression. Metab Brain Dis 39:1613\u20131636","journal-title":"Metab Brain Dis"},{"key":"2004_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-025-63277-6","volume":"16","author":"J Migeot","year":"2025","unstructured":"Migeot J, Pina-Escudero SD, Hernandez H et al (2025) Social exposome and brain health outcomes of dementia across Latin America. Nat Commun 2025 16:1. https:\/\/doi.org\/10.1038\/s41467-025-63277-6","journal-title":"Nat Commun 2025"},{"key":"2004_CR95","doi-asserted-by":"publisher","first-page":"101234","DOI":"10.1016\/j.molmet.2021.101234","volume":"52","author":"JL Milstein","year":"2021","unstructured":"Milstein JL, Ferris HA (2021) The brain as an insulin-sensitive metabolic organ. Mol Metab 52:101234","journal-title":"Mol Metab"},{"key":"2004_CR96","first-page":"1078","volume":"14","author":"D Nagpal","year":"2025","unstructured":"Nagpal D, Nema S, Nagpal S et al (2025) Management and prevention of neurodegenerative disorders. Can antioxidant-rich diet interventions help? Antioxid 14:1078","journal-title":"Can Antioxidant-Rich Diet Interventions Help? Antioxid"},{"key":"2004_CR97","doi-asserted-by":"crossref","unstructured":"Namgyal D, Lim C-S (2025) Circadian rhythm dysfunction in neurodegenerative diseases: a bidirectional perspective and therapeutic potential. Nat Sci Sleep 2969\u20132989","DOI":"10.2147\/NSS.S561326"},{"key":"2004_CR98","doi-asserted-by":"publisher","first-page":"e57011","DOI":"10.7554\/eLife.57011","volume":"9","author":"H-V Ngo","year":"2020","unstructured":"Ngo H-V, Fell J, Staresina B (2020) Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples. Elife 9:e57011","journal-title":"Elife"},{"key":"2004_CR99","doi-asserted-by":"publisher","unstructured":"Nichols E, Keller KP, Chang H et al (2025) Key research priorities in methodological approaches for measuring the exposome and studying its role in the development of dementia. Alzheimers Dement 21. https:\/\/doi.org\/10.1002\/ALZ.70928","DOI":"10.1002\/ALZ.70928"},{"key":"2004_CR100","doi-asserted-by":"publisher","first-page":"CD016297","DOI":"10.1002\/14651858.CD016297","volume":"2026","author":"F Nonino","year":"2026","unstructured":"Nonino F, Minozzi S, Sambati L et al (2026) Amyloid-beta\u2010targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer\u2019s disease. Cochrane Database Syst Rev 2026:CD016297. https:\/\/doi.org\/10.1002\/14651858.CD016297","journal-title":"Cochrane Database Syst Rev"},{"key":"2004_CR101","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3390\/metabo10110454","volume":"10","author":"M Ore\u0161i\u010d","year":"2020","unstructured":"Ore\u0161i\u010d M, McGlinchey A, Wheelock CE, Hy\u00f6tyl\u00e4inen T (2020) Metabolic signatures of the exposome\u2014Quantifying the impact of exposure to environmental chemicals on human health. Metabolites 10:454","journal-title":"Metabolites"},{"key":"2004_CR102","doi-asserted-by":"publisher","first-page":"104820","DOI":"10.1016\/j.nbd.2020.104820","volume":"139","author":"JE Owen","year":"2020","unstructured":"Owen JE, Veasey SC (2020) Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models. Neurobiol Dis 139:104820","journal-title":"Neurobiol Dis"},{"key":"2004_CR103","doi-asserted-by":"publisher","first-page":"e00027","DOI":"10.1097\/IN9.0000000000000027","volume":"5","author":"BD Paneru","year":"2023","unstructured":"Paneru BD, Hill DA (2023) The role of extracellular vesicle-derived miRNAs in adipose tissue function and metabolic health. Immunometabolism 5:e00027","journal-title":"Immunometabolism"},{"key":"2004_CR104","doi-asserted-by":"crossref","unstructured":"Pataky MW, Young WF, Nair KS (2021) Hormonal and metabolic changes of aging and the influence of lifestyle modifications. In: Mayo Clinic Proceedings. Elsevier, pp 788\u2013814","DOI":"10.1016\/j.mayocp.2020.07.033"},{"key":"2004_CR105","first-page":"247","volume":"16","author":"P Patel","year":"2025","unstructured":"Patel P, Patil S, Kaur N (2025) Estrogen and metabolism: Navigating hormonal transitions from perimenopause to postmenopause. J Midlife Health 16:247\u2013256","journal-title":"J Midlife Health"},{"key":"2004_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/BJBS.2026.16085\/FULL","volume":"83","author":"B Peng","year":"2026","unstructured":"Peng B, Zhao W, Kong M et al (2026) Pleiotropic effects of GDF-15 to regulate nutritional status: Perspectives from body composition to nutrition-related disorders. Br J Biomed Sci 83:1\u201320. https:\/\/doi.org\/10.3389\/BJBS.2026.16085\/FULL","journal-title":"Br J Biomed Sci"},{"key":"2004_CR107","doi-asserted-by":"crossref","unstructured":"Pini L, Imbimbo BP, Griffa A et al (2025) Targeting brain connectivity in Alzheimer\u2019s disease with repurposed drugs. Ageing Res Rev 103001","DOI":"10.1016\/j.arr.2025.103001"},{"key":"2004_CR108","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/ijms27031222","volume":"27","author":"M Pliszka","year":"2026","unstructured":"Pliszka M, Szablewski L (2026) Insulin Signaling in Alzheimer\u2019s Disease: Association with Brain Insulin Resistance. Int J Mol Sci 27:1222","journal-title":"Int J Mol Sci"},{"key":"2004_CR109","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.3390\/ijms26094209","volume":"26","author":"T Ponce-Lopez","year":"2025","unstructured":"Ponce-Lopez T (2025) Peripheral inflammation and insulin resistance: their impact on blood\u2013brain barrier integrity and glia activation in Alzheimer\u2019s disease. Int J Mol Sci 26:4209","journal-title":"Int J Mol Sci"},{"key":"2004_CR110","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/ana.26897","volume":"95","author":"SA Sakowski","year":"2024","unstructured":"Sakowski SA, Koubek EJ, Chen KS et al (2024) Role of the exposome in neurodegenerative disease: Recent insights and future directions. Ann Neurol 95:635\u2013652","journal-title":"Ann Neurol"},{"key":"2004_CR111","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/JNN.0b013e3182527690","volume":"44","author":"AC Sartori","year":"2012","unstructured":"Sartori AC, Vance DE, Slater LZ, Crowe M (2012) The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research. J Neurosci Nurs 44:206\u2013217","journal-title":"J Neurosci Nurs"},{"key":"2004_CR112","doi-asserted-by":"crossref","unstructured":"Schickedanz H, Safaeipour C, Sherzai D, Sherzai A (2026) Effects of lifestyle medicine on Alzheimer\u2019s disease: Insights from emerging evidence and multi-domain interventions. Am J Lifestyle Med 15598276261417272","DOI":"10.1177\/15598276261417271"},{"key":"2004_CR113","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/biomedicines6020058","volume":"6","author":"ML Schmitz","year":"2018","unstructured":"Schmitz ML, Shaban MS, Albert BV et al (2018) The crosstalk of endoplasmic reticulum (ER) stress pathways with NF-\u03baB: complex mechanisms relevant for cancer, inflammation and infection. Biomedicines 6:58","journal-title":"Biomedicines"},{"key":"2004_CR114","doi-asserted-by":"publisher","first-page":"fcae128","DOI":"10.1093\/braincomms\/fcae128","volume":"6","author":"S Seoane","year":"2024","unstructured":"Seoane S, Van Den Heuvel M, Acebes \u00c1, Janssen N (2024) The subcortical default mode network and Alzheimer\u2019s disease: a systematic review and meta-analysis. Brain Commun 6:fcae128","journal-title":"Brain Commun"},{"key":"2004_CR115","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"SE Shoelson","year":"2006","unstructured":"Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793\u20131801","journal-title":"J Clin Invest"},{"key":"2004_CR116","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.3390\/diagnostics15233068","volume":"15","author":"C Simfukwe","year":"2025","unstructured":"Simfukwe C, An SSA, Youn YC (2025) Mechanisms and impact of cognitive reserve in normal aging and Alzheimer\u2019s disease. Diagnostics 15:3068","journal-title":"Diagnostics"},{"key":"2004_CR117","first-page":"1546","volume":"59","author":"S Singh","year":"2023","unstructured":"Singh S, Sarma DK, Verma V et al (2023) From cells to environment: Exploring the interplay between factors shaping bone health and disease. Med (B Aires) 59:1546","journal-title":"Med (B Aires)"},{"key":"2004_CR118","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41398-022-02120-8","volume":"12","author":"R Singla","year":"2022","unstructured":"Singla R, Mishra A, Cao R (2022) The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model. Transl Psychiatry 12:355","journal-title":"Transl Psychiatry"},{"key":"2004_CR119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.07.003","volume":"61","author":"EE Spangenberg","year":"2017","unstructured":"Spangenberg EE, Green KN (2017) Inflammation in Alzheimer\u2019s disease: lessons learned from microglia-depletion models. Brain Behav Immun 61:1\u201311","journal-title":"Brain Behav Immun"},{"key":"2004_CR120","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuroscience.2010.06.038","volume":"170","author":"N Sportiche","year":"2010","unstructured":"Sportiche N, Suntsova N, Methippara M et al (2010) Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis. Neuroscience 170:247\u2013258","journal-title":"Neuroscience"},{"key":"2004_CR121","doi-asserted-by":"publisher","first-page":"e45078","DOI":"10.1371\/JOURNAL.PONE.0045078","volume":"7","author":"AB Tam","year":"2012","unstructured":"Tam AB, Mercado EL, Hoffmann A, Niwa M (2012) ER Stress activates NF-\u03baB by integrating functions of basal IKK Activity, IRE1 and PERK. PLoS ONE 7:e45078. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0045078","journal-title":"PLoS ONE"},{"key":"2004_CR122","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.3390\/nu11112579","volume":"11","author":"BL Tan","year":"2019","unstructured":"Tan BL, Norhaizan ME (2019) Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function. Nutrients 11:2579","journal-title":"Nutrients"},{"key":"2004_CR123","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s41105-025-00620-w","volume":"24","author":"L Tan","year":"2026","unstructured":"Tan L, Zhang X, Fu Z et al (2026) Effect of CPAP treatment on subjective cognitive decline in patients with mild obstructive sleep apnea syndrome. Sleep Biol Rhythms 24:123\u2013130","journal-title":"Sleep Biol Rhythms"},{"key":"2004_CR124","doi-asserted-by":"publisher","first-page":"1716291","DOI":"10.3389\/FNAGI.2026.1716291\/FULL","volume":"18","author":"S Tang","year":"2026","unstructured":"Tang S, Liao Y, Yang M, Yue R (2026) Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities. Front Aging Neurosci 18:1716291. https:\/\/doi.org\/10.3389\/FNAGI.2026.1716291\/FULL","journal-title":"Front Aging Neurosci"},{"key":"2004_CR125","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1113\/JP272114","volume":"594","author":"AN Vgontzas","year":"2016","unstructured":"Vgontzas AN, Gaines J, Ryan S, McNicholas WT (2016) CrossTalk proposal: metabolic syndrome causes sleep apnoea. J Physiol 594:4687","journal-title":"J Physiol"},{"key":"2004_CR126","doi-asserted-by":"publisher","first-page":"123","DOI":"10.17759\/cpse.2022110208","volume":"11","author":"J Walker","year":"2022","unstructured":"Walker J, Muench A, Perlis ML, Vargas I (2022) Cognitive behavioral therapy for insomnia (CBT-I): a primer. Klinicheskaia i spetsial\u2019naia psikhologiia=. Clin Psychol special Educ 11:123","journal-title":"Clin Psychol special Educ"},{"key":"2004_CR127","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1212\/WNL.0000000000004688","volume":"89","author":"KA Walker","year":"2017","unstructured":"Walker KA, Hoogeveen RC, Folsom AR et al (2017) Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study. Neurology 89:2262\u20132270. https:\/\/doi.org\/10.1212\/WNL.0000000000004688","journal-title":"Neurology"},{"issue":"1","key":"2004_CR128","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/S43556-026-00489-2","volume":"7","author":"NN Wang","year":"2026","unstructured":"Wang NN, Liu ZJ, Wang Y et al (2026) Glymphatic system impairment in neurological disorders: Potential mechanisms and therapeutic targets. Mol Biomed 2026 7(1):89. https:\/\/doi.org\/10.1186\/S43556-026-00489-2","journal-title":"Mol Biomed 2026"},{"key":"2004_CR129","first-page":"136","volume":"3","author":"W-Y Wang","year":"2015","unstructured":"Wang W-Y, Tan M-S, Yu J-T, Tan L (2015) Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease. Ann Transl Med 3:136","journal-title":"Ann Transl Med"},{"key":"2004_CR130","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/brainsci14010041","volume":"14","author":"DF Weaver","year":"2023","unstructured":"Weaver DF (2023) Thirty risk factors for Alzheimer\u2019s disease unified by a common neuroimmune\u2013neuroinflammation mechanism. Brain Sci 14:41","journal-title":"Brain Sci"},{"key":"2004_CR131","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/S40035-026-00573-1","volume":"15","author":"M Xiang","year":"2026","unstructured":"Xiang M, Cao SY, Sun XH et al (2026) Brain insulin resistance as a driver of proteinopathy in neurodegeneration: from cell-type-specific mechanisms to targeted therapeutics. Transl Neurodegener 15:36. https:\/\/doi.org\/10.1186\/S40035-026-00573-1","journal-title":"Transl Neurodegener"},{"issue":"1 17","key":"2004_CR132","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/S13195-025-01724-8","volume":"17","author":"H Yang","year":"2025","unstructured":"Yang H, Niu L, Tian L et al (2025) Circadian rhythm disturbances in Alzheimer\u2019s disease: insights from plaque-free and plaque-burdened stages in APPSWE\/PS1dE9 mice. Alzheimer\u2019s Res Therapy 2025 17(1 17):76\u2013. https:\/\/doi.org\/10.1186\/S13195-025-01724-8","journal-title":"Alzheimer\u2019s Res Therapy 2025"},{"key":"2004_CR133","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1017\/S0007114524001405","volume":"132","author":"X Yu","year":"2024","unstructured":"Yu X, Pu H, Voss M (2024) Overview of anti-inflammatory diets and their promising effects on non-communicable diseases. Br J Nutr 132:898\u2013918","journal-title":"Br J Nutr"},{"key":"2004_CR134","doi-asserted-by":"publisher","first-page":"8272","DOI":"10.3390\/ijms26178272","volume":"26","author":"Y Yu","year":"2025","unstructured":"Yu Y, Wang Z, Chai Z et al (2025) Central nervous system-derived extracellular vesicles as biomarkers in Alzheimer\u2019s disease. Int J Mol Sci 26:8272","journal-title":"Int J Mol Sci"},{"key":"2004_CR135","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3390\/biom9120877","volume":"9","author":"A Zalewska","year":"2019","unstructured":"Zalewska A, Maciejczyk M, Szulimowska J et al (2019) High-fat diet affects ceramide content, disturbs mitochondrial redox balance, and induces apoptosis in the submandibular glands of mice. Biomolecules 9:877","journal-title":"Biomolecules"},{"key":"2004_CR136","doi-asserted-by":"publisher","unstructured":"Zhang G, Meng L, Wang Z et al (2022) Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer\u2019s disease. Mol Neurodegener 17. https:\/\/doi.org\/10.1186\/S13024-022-00518-Y","DOI":"10.1186\/S13024-022-00518-Y"},{"key":"2004_CR137","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/13872877251400667","volume":"109","author":"S Zhang","year":"2026","unstructured":"Zhang S, Wang T, Xue G et al (2026) Dysregulated mTOR signaling in Alzheimer\u2019s disease: Linking pathogenic mechanisms to emerging therapeutic strategies. J Alzheimers Dis 109:526\u2013544. https:\/\/doi.org\/10.1177\/13872877251400667","journal-title":"J Alzheimers Dis"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-02004-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-02004-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-026-02004-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:02:41Z","timestamp":1792746161000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11011-026-02004-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":137,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2004"],"URL":"https:\/\/doi.org\/10.1007\/s11011-026-02004-6","relation":{},"ISSN":["1573-7365"],"issn-type":[{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"16 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"245"}}