{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:24:36Z","timestamp":1783959876248,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB235785"],"award-info":[{"award-number":["CB235785"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["M1930"],"award-info":[{"award-number":["M1930"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s11030-018-9883-7","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T09:20:28Z","timestamp":1538558428000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design, synthesis and in vitro evaluation of a Dopa-organoboron compound that acts as a bladder relaxant through non-catecholamine receptors"],"prefix":"10.1007","volume":"23","author":[{"given":"Ana L.","family":"Ocampo-N\u00e9stor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"L\u00f3pez-Mayorga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique F.","family":"Castillo-Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzia I.","family":"Padilla-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 G.","family":"Trujillo-Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-1502","authenticated-orcid":false,"given":"Marvin A.","family":"Soriano-Urs\u00faa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"9883_CR1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S1570-9124(03)00035-7","volume":"1","author":"A Bannowsky","year":"2003","unstructured":"Bannowsky A, Juenemann KP (2003) Innervation and function of the female urinary bladder and urethra. EAU Updat Ser 1:120\u2013127. https:\/\/doi.org\/10.1016\/S1570-9124(03)00035-7","journal-title":"EAU Updat Ser"},{"key":"9883_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.eursup.2004.10.004","volume":"4","author":"MC Michel","year":"2005","unstructured":"Michel MC, Oelke M, Peters SLM (2005) The neuro-urological connection. Eur Urol Suppl 4:18\u201328. https:\/\/doi.org\/10.1016\/j.eursup.2004.10.004","journal-title":"Eur Urol Suppl"},{"key":"9883_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/sj.bjp.0706619","volume":"147","author":"MC Michel","year":"2006","unstructured":"Michel MC, Vrydag W (2006) \u03b11-, \u03b12- and \u03b2-Adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 147:88\u2013119. https:\/\/doi.org\/10.1038\/sj.bjp.0706619","journal-title":"Br J Pharmacol"},{"issue":"3","key":"9883_CR4","doi-asserted-by":"publisher","first-page":"744.e1","DOI":"10.1016\/j.urology.2013.05.027","volume":"82","author":"SAY Afeli","year":"2013","unstructured":"Afeli SAY, Rovner ES, Petkov GV (2013) BRL37344, a \u03b23-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology 82(3):744.e1\u2013744.e7. https:\/\/doi.org\/10.1016\/j.urology.2013.05.027","journal-title":"Urology"},{"key":"9883_CR5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/bph.13367","volume":"173","author":"EC Alexandre","year":"2016","unstructured":"Alexandre EC, Kiguti LR, Calmasini FB, Silva FH, Da Silva KP, Ferreira R, Ribeiro CA, Monica FZ, Pupo AS, Antunes E (2016) Mirabegron relaxes urethral smooth muscle by a dual mechanism involving \u03b23-adrenoceptor activation and \u03b11-adrenoceptor blockade. Br J Pharmacol 173:415\u2013428. https:\/\/doi.org\/10.1111\/bph.13367","journal-title":"Br J Pharmacol"},{"key":"9883_CR6","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00210-014-1039-4","volume":"387","author":"H Cernecka","year":"2014","unstructured":"Cernecka H, Pradidarcheep W, Lamers WH, Schmidt M, Michel MC (2014) Rat \u03b23-adrenoceptor protein expression: antibody validation and distribution in rat gastrointestinal and urogenital tissues. Naunyn Schmiedebergs Arch Pharmacol 387:1117\u20131127. https:\/\/doi.org\/10.1007\/s00210-014-1039-4","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"9883_CR7","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00210-013-0900-1","volume":"386","author":"T Hatanaka","year":"2013","unstructured":"Hatanaka T, Ukai M, Watanabe M, Someya A, Ohtake A, Suzuki M, Ueshima K, Sato S, Masuda N (2013) Pharmacological profile of the selective \u03b23-adrenoceptor agonist mirabegron in cynomolgus monkeys. Naunyn Schmiedeberg\u2019s Arch Pharmacol 386:1001\u20131008. https:\/\/doi.org\/10.1007\/s00210-013-0900-1","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"9883_CR8","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1021\/jm4017224","volume":"57","author":"CR Moyes","year":"2014","unstructured":"Moyes CR, Berger R, Goble SD, Harper B, Shen D, Wang L, Bansal A, Brown PN, Chen AS, Dingley KH, Di Salvo J, Fitzmaurice A, Gichuru LN, Hurley AL, Jochnowitz N, Miller RR, Mistry S, Nagabukuro H, Salituro GM, Sanfiz A, Stevenson AS, Villa K, Zamlynny B, Struthers M, Weber AE, Edmondson SD (2014) Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective \u03b23 adrenergic receptor agonists for the treatment of overactive bladder. J Med Chem 57:1437\u20131453. https:\/\/doi.org\/10.1021\/jm4017224","journal-title":"J Med Chem"},{"key":"9883_CR9","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1124\/jpet.116.237313","volume":"360","author":"J Salvo Di","year":"2017","unstructured":"Di Salvo J, Nagabukuro H, Wickham LA, Abbadie C, DeMartino JA, Fitzmaurice A, Gichuru L, Kulick A, Donnelly MJ, Jochnowitz N, Hurley AL, Pereira A, Sanfiz A, Veronin G, Villa K, Woods J, Zamlynny B, Zycband E, Salituro GM, Frenkl T, Weber AE, Edmondson SD, Struthers M (2017) Pharmacological characterization of a novel beta 3 adrenergic agonist, vibegron: evaluation of antimuscarinic receptor selectivity for combination therapy for overactive bladder. J Pharmacol Exp Ther J Pharmacol Exp Ther 360:346\u2013355. https:\/\/doi.org\/10.1124\/jpet.116.237313","journal-title":"J Pharmacol Exp Ther J Pharmacol Exp Ther"},{"key":"9883_CR10","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.lfs.2005.09.023","volume":"78","author":"M Ahmed","year":"2006","unstructured":"Ahmed M, Ishiguro M, Nagatomo T (2006) Molecular modeling of SWR-0342SA, a \u03b23-selective agonist, with \u03b21- and \u03b23-adrenoceptor. Life Sci 78:2019\u20132023. https:\/\/doi.org\/10.1016\/j.lfs.2005.09.023","journal-title":"Life Sci"},{"key":"9883_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.pharmthera.2016.01.007","volume":"159","author":"MC Michel","year":"2016","unstructured":"Michel MC, Korstanje C (2016) \u03b23-Adrenoceptor agonists for overactive bladder syndrome: role of translational pharmacology in a repositioning clinical drug development project. Pharmacol Ther 159:66\u201382. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.01.007","journal-title":"Pharmacol Ther"},{"key":"9883_CR12","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.1016\/j.bmcl.2010.08.040","volume":"20","author":"MA Soriano-Urs\u00faa","year":"2010","unstructured":"Soriano-Urs\u00faa MA, Correa-Basurto J, Valencia-Hern\u00e1ndez I, Amezcua-Guti\u00e9rrez MA, Padilla-Mart\u00ednez II, Trujillo-Ferrara JG (2010) Design, synthesis and in vitro evaluation of (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate: a novel salbutamol derivative with high intrinsic efficacy on the \u03b22 adrenoceptor. Bioorganic Med Chem Lett 20:5623\u20135629. https:\/\/doi.org\/10.1016\/j.bmcl.2010.08.040","journal-title":"Bioorganic Med Chem Lett"},{"key":"9883_CR13","doi-asserted-by":"publisher","first-page":"8207","DOI":"10.1021\/jm400471z","volume":"56","author":"MA Soriano-Urs\u00faa","year":"2013","unstructured":"Soriano-Urs\u00faa MA, Trujillo-Ferrara JG, Correa-Basurto J, Vilar S (2013) Recent structural advances of \u03b21 and \u03b22 adrenoceptors yield keys for ligand recognition and drug design. J Med Chem 56:8207\u20138223. https:\/\/doi.org\/10.1021\/jm400471z","journal-title":"J Med Chem"},{"issue":"4","key":"9883_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.4155\/bio.10.208","volume":"3","author":"AG Goz\u00e1lez","year":"2011","unstructured":"Goz\u00e1lez AG, Zavala LC, Moreno AP, San Juan ER, Ferrara JG, Espinosa LR, Marcel\u00edn-Jim\u00e9nez G (2011) Pharmacokinetics of diphenylboroxazolidones of L-\u03b1-amino acids with activity on the CNS: quantification in rat DBS by UPLC\u2013MS\/MS. Bioanalysis 3(4):439\u2013448. https:\/\/doi.org\/10.4155\/bio.10.208","journal-title":"Bioanalysis"},{"key":"9883_CR15","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/chir.20072","volume":"16","author":"JM Araujo-Alvarez","year":"2004","unstructured":"Araujo-Alvarez JM, Querejeta E, Oviedo A, Trujillo-Ferrara JG (2004) Stereospecific activity of two glutamate analogs. Chirality 16:586\u2013591. https:\/\/doi.org\/10.1002\/chir.20072","journal-title":"Chirality"},{"key":"9883_CR16","unstructured":"Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Scalmani, Barone V, Mennucci B, Petersson GA, Nakatsuji H, Caricato M, Li X, Hratchian HP, Izmaylov AF, Bloino J, Zheng G, Sonnenberg JL, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Vreven T, Montgomery JA, Peralta Jr JE, Ogliaro F, Bearpark M, Heyd JJ, Brothers E, Kudin KN, Staroverov VN, Kobayashi R, Normand J, Raghavachari K, Rendell A, Burant JC, Iyengar SS, Tomasi J, Cossi M, Rega N, Millam JM, Klene M, Knox JE, Cross JB, Bakken V, Adamo C, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Martin RL, Morokuma K, Zakrzewski VG, Voth GA, Salvador P, Dannenberg JJ, Dapprich S, Daniels AD, Farkas \u00d6, Foresman JB, Ortiz JV, Cioslowski J, Fox DJ (2009) Gaussian, Inc., Gaussian 09, Pittsburgh PA"},{"key":"9883_CR17","unstructured":"How do I add new atom types to AutoDock 4?\u2014AutoDock. http:\/\/autodock.scripps.edu\/faqs-help\/faq\/how-do-i-add-new-atom-types-to-autodock-4"},{"issue":"11","key":"9883_CR18","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.ejmech.2005.06.011","volume":"40","author":"A Tafi","year":"2005","unstructured":"Tafi A, Agamennone M, Tortorella P, Alcaro S, Gallina C, Botta M (2005) AMBER force field implementation of the boronate function to simulate the inhibition of \u03b2-lactamases by alkyl and aryl boronic acids. Eur J Med Chem 40(11):1134\u20131142. https:\/\/doi.org\/10.1016\/j.ejmech.2005.06.011","journal-title":"Eur J Med Chem"},{"key":"9883_CR19","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.bmcl.2014.12.077","volume":"25","author":"MA Soriano-Urs\u00faa","year":"2015","unstructured":"Soriano-Urs\u00faa MA, Arias-Monta\u00f1o JA, Correa-Basurto J, Hern\u00e1ndez-Mart\u00ednez CF, L\u00f3pez-Cabrera Y, Castillo-Hern\u00e1ndez MC, Padilla-Mart\u00ednez II, Trujillo-Ferrara JG (2015) Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the \u03b22 adrenoceptor. Bioorganic Med Chem Lett 25:820\u2013825. https:\/\/doi.org\/10.1016\/j.bmcl.2014.12.077","journal-title":"Bioorganic Med Chem Lett"},{"key":"9883_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427","author":"A Waterhouse","year":"2018","unstructured":"Waterhouse A, Bertoni M, Bienert S, Studer G, Tauriello G, Gumienny R, Heer FT, de Beer TAP, Rempfer C, Bordoli L, Lepore R, Schwede T (2018) SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gky427","journal-title":"Nucleic Acids Res"},{"key":"9883_CR21","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"JC Phillips","year":"2005","unstructured":"Phillips JC, Braun R, Wang W, Gumbart J, Tajkhorshid E, Villa E, Chipot C, Skeel RD, Kale L, Schulten K (2005) Scalable molecular dynamics with NAMD. J Comput Chem 26:1781\u20131802. https:\/\/doi.org\/10.1002\/jcc.20289","journal-title":"J Comput Chem"},{"key":"9883_CR22","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/j.1476-5381.2010.00754.x","volume":"160","author":"JG Baker","year":"2010","unstructured":"Baker JG (2010) The selectivity of \u03b2-adrenoceptor agonists at human \u03b21-, \u03b22- and \u03b23-adrenoceptors: research paper. Br J Pharmacol 160:1048\u20131061. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00754.x","journal-title":"Br J Pharmacol"},{"key":"9883_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1414-431x20165304","volume":"49","author":"J Lozano-Cuenca","year":"2016","unstructured":"Lozano-Cuenca J, L\u00f3pez-Canales OA, Aguilar-Carrasco JC, Villagrana-Zesati JR, L\u00f3pez-Mayorga RM, Castillo-Henkel EF, L\u00f3pez-Canales JS (2016) Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings. Braz J Med Biol Res 49:1\u20139. https:\/\/doi.org\/10.1590\/1414-431X20165304","journal-title":"Braz J Med Biol Res"},{"key":"9883_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1474-8673.2010.00457.x","volume":"30","author":"MC Castillo-Hern\u00e1ndez","year":"2010","unstructured":"Castillo-Hern\u00e1ndez MC, Martinez-Godinez MA, Guevara-Balcazar G, Miliar-Garcia A, Mancilla J, Lopez-Mayorga RM, Castillo-Henkel EF, Castillo-Henkel C (2010) Extraendothelial and constitutive COX-2 expression is involved in the contractile effect of angiotensin II in the rat aorta. Auton Autacoid Pharmacol 30:205\u2013211. https:\/\/doi.org\/10.1111\/j.1474-8673.2010.00457.x","journal-title":"Auton Autacoid Pharmacol"},{"key":"9883_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/sj.bjp.0706048","volume":"144","author":"JG Baker","year":"2005","unstructured":"Baker JG (2005) The selectivity of \u03b2-adrenoceptor antagonists at the human \u03b21, \u03b22 and \u03b23 adrenoceptors. Br J Pharmacol 144:317\u2013322. https:\/\/doi.org\/10.1038\/sj.bjp.0706048","journal-title":"Br J Pharmacol"},{"key":"9883_CR26","doi-asserted-by":"publisher","first-page":"R1654","DOI":"10.1152\/ajpregu.1998.275.5.R1654","volume":"275","author":"AS Braverman","year":"1998","unstructured":"Braverman AS, Luthin GR, Ruggieri MR (1998) M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder. Am J Physiol Regul Integr Comp Physiol 275:R1654\u2013R1660","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9883_CR27","unstructured":"Graphpad Prism version 5.03 for Windows, GraphPad Software, La Jolla California, USA. www.graphpad.com"},{"issue":"1","key":"9883_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bmcl.2015.11.030","volume":"26","author":"C Zhu","year":"2016","unstructured":"Zhu C, Kar NF, Li B, Costa M, Dingley KH, Di Salvo J, Ha SN, Hurley AL, Li X, Miller RR, Salituro GM, Struthers M, Weber AE, Hale JJ, Edmondson SD (2016) Discovery of benzamides as potent human \u03b23\u00a0adrenergic\u00a0receptor agonists. Bioorg Med Chem Lett 26(1):55\u201359. https:\/\/doi.org\/10.1016\/j.bmcl.2015.11.030","journal-title":"Bioorg Med Chem Lett"},{"issue":"15","key":"9883_CR29","doi-asserted-by":"publisher","first-page":"6048","DOI":"10.1021\/acs.jmedchem.5b00638","volume":"58","author":"Y Wada","year":"2015","unstructured":"Wada Y, Shirahashi H, Iwanami T, Ogawa M, Nakano S, Morimoto A, Kasahara K, Tanaka E, Takada Y, Ohashi S, Mori M, Shuto S (2015) Discovery of novel indazole derivatives as highly potent and selective human \u03b23-adrenergic receptor agonists with the possibility of having no cardiovascular side effects. J Med Chem 58(15):6048\u20136057. https:\/\/doi.org\/10.1021\/acs.jmedchem.5b00638","journal-title":"J Med Chem"},{"issue":"8","key":"9883_CR30","doi-asserted-by":"publisher","first-page":"3252","DOI":"10.1021\/acs.jmedchem.6b01197","volume":"60","author":"Y Wada","year":"2017","unstructured":"Wada Y, Nakano S, Morimoto A, Kasahara KI, Hayashi T, Takada Y, Suzuki H, Niwa-Sakai M, Ohashi S, Mori M, Hirokawa T, Shuto S (2017) Discovery of novel indazole derivatives as orally available \u03b23-adrenergic receptor agonists lacking off-target-based cardiovascular side effects. J Med Chem 60(8):3252\u20133265. https:\/\/doi.org\/10.1021\/acs.jmedchem.6b01197","journal-title":"J Med Chem"},{"key":"9883_CR31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1464-410X.1994.tb07629.x","volume":"73","author":"S Escaf","year":"1994","unstructured":"Escaf S, Cavallotti C, Ricci A, Vega JA, Amenta F (1994) Dopamine D1 and D2 receptors in the human ureter and urinary bladder: a radioligand binding and autoradiographic study. Br J Urol 73:473\u2013479. https:\/\/doi.org\/10.1111\/j.1464-410X.1994.tb07629.x","journal-title":"Br J Urol"},{"issue":"3","key":"9883_CR32","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0022-3565(25)24123-4","volume":"248","author":"ML Cohen","year":"1989","unstructured":"Cohen ML, Drey K (1989) Contractile responses in bladder body, bladder neck and prostate from rat, guinea pig and cat. J Pharmacol Exp Ther 248(3):1063\u20131068","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"9883_CR33","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s00210-002-0596-0","volume":"366","author":"T Imai","year":"2002","unstructured":"Imai T, Tanaka Y, Okamoto T, Horinouchi T, Tanaka H, Koike K, Shigenobu K (2002) 2-Aminoethoxydiphenyl borate causes dissociation between membrane electrical and mechanical activity in guinea-pig urinary bladder smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 366(3):282\u2013285. https:\/\/doi.org\/10.1007\/s00210-002-0596-0","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"9883_CR34","doi-asserted-by":"publisher","first-page":"6","DOI":"10.5213\/inj.1734850.425","volume":"21","author":"KE Andersson","year":"2017","unstructured":"Andersson KE (2017) On the site and mechanism of action of \u03b23-adrenoceptor agonists in the bladder. Int Neurourol J 21(1):6\u201311. https:\/\/doi.org\/10.5213\/inj.1734850.425","journal-title":"Int Neurourol J"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-018-9883-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11030-018-9883-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-018-9883-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:30:42Z","timestamp":1761107442000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11030-018-9883-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["9883"],"URL":"https:\/\/doi.org\/10.1007\/s11030-018-9883-7","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]},"assertion":[{"value":"26 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animals involving were maintained and handled according to the guidelines for Use and Care of Laboratory Animals (NOM-062-ZOO-1999, Ministry of Agriculture and Livestock, SAGARPA, Mexico), and the protocol was approved by the institutional committee for animal use.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights statement"}}]}}