{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:42:18Z","timestamp":1772574138385,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Operational Program Competitiveness, Entrepreneurship","award":["T1EDK-02990"],"award-info":[{"award-number":["T1EDK-02990"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s11030-019-10014-z","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T14:03:19Z","timestamp":1573480999000},"page":"1095-1106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antiproliferative activity and apoptosis induction, of organo-antimony(III)\u2013copper(I) conjugates, against human breast cancer cells"],"prefix":"10.1007","volume":"24","author":[{"given":"C. N.","family":"Banti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Tsiatouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Karanicolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Panagiotou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Tasiopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kourkoumelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-6266","authenticated-orcid":false,"given":"S. K.","family":"Hadjikakou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"10014_CR1","doi-asserted-by":"publisher","unstructured":"Harbeck N, Penault-FLlorca F, Cortes J, Gnant M, Houssami N, Poortmans P, Ruddy K, Tsang J, Cardoso F (2019) Breast cancer. Nat Rev Dis Primers 5, Article citation ID: 66. https:\/\/doi.org\/10.1038\/s41572-019-0111-2","DOI":"10.1038\/s41572-019-0111-2"},{"key":"10014_CR2","doi-asserted-by":"publisher","first-page":"14568","DOI":"10.1039\/C2DT31527K","volume":"41","author":"DB Shpakovsky","year":"2012","unstructured":"Shpakovsky DB, Banti CN, Beaulieu-Houle G, Kourkoumelis N, Manoli M, Manos MJ, Tasiopoulos AJ, Hadjikakou SK, Milaeva ER, Charalabopoulos K, Bakas T, Butler IS, Hadjiliadis N (2012) Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride and its complexes. Dalton Trans 41:14568. https:\/\/doi.org\/10.1039\/C2DT31527K","journal-title":"Dalton Trans"},{"key":"10014_CR3","doi-asserted-by":"publisher","unstructured":"Mazumdar A, Tahaney WM, Reddy Bollu L, Poage G, Hill J, Zhang Y, Mills GB, Brown PH (2019) The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression. npj Breast Cancer 5, Article number: 22. https:\/\/doi.org\/10.1038\/s41523-019-0118-6","DOI":"10.1038\/s41523-019-0118-6"},{"key":"10014_CR4","doi-asserted-by":"publisher","unstructured":"Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Oliver Schink K, Olsen CE, W\u00e4lchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019) Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy. npj Breast Cancer 5, Article number: 13. https:\/\/doi.org\/10.1038\/s41523-019-0108-8","DOI":"10.1038\/s41523-019-0108-8"},{"key":"10014_CR5","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.21873\/anticanres.13410","volume":"39","author":"T Hero","year":"2019","unstructured":"Hero T, B\u00fchler H, Kouam PN, Priesch-Grzeszowiak B, Lateit T, Adamietz IA (2019) The triple-negative breast cancer cell line MDA-MB 231 is specifically inhibited by the ionophore salinomycin. Anticancer Res 39:2821\u20132827. https:\/\/doi.org\/10.21873\/anticanres.13410","journal-title":"Anticancer Res"},{"key":"10014_CR6","doi-asserted-by":"publisher","unstructured":"Ahmad Khan R., Usman M, Dhivya R, Balaji P, Alsalme A, AlLohedan H, Arjmand F, AlFarhan K, Abdulkader Akbarsha M, Marchetti F, Pettinari C, Tabassum S (2017) Heteroleptic copper(I) complexes of \u201cscorpionate\u201d bis-pyrazolyl carboxylate ligand with auxiliary phosphine as potential anticancer agents: an insight into cytotoxic mode. Sci Rep 7, Article number: 45229. https:\/\/doi.org\/10.1038\/srep45229","DOI":"10.1038\/srep45229"},{"key":"10014_CR7","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1039\/C5DT04011F","volume":"45","author":"UK Komarnicka","year":"2016","unstructured":"Komarnicka UK, Starosta R, P\u0142otek M, de Almeida RFM, Je\u017cowska-Bojczuk M, Kyzio\u0142 A (2016) Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode. Dalton Trans 45:5052\u20135063. https:\/\/doi.org\/10.1039\/C5DT04011F","journal-title":"Dalton Trans"},{"key":"10014_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jinorgbio.2015.06.006","volume":"153","author":"SK Hadjikakou","year":"2015","unstructured":"Hadjikakou SK, Ozturk II, Banti CN, Kourkoumelis N, Hadjiliadis N (2015) Recent advances on antimony(III\/V) compounds with potential activity against tumor cells. J Inorg Biochem 153:293\u2013305. https:\/\/doi.org\/10.1016\/j.jinorgbio.2015.06.006","journal-title":"J Inorg Biochem"},{"key":"10014_CR9","doi-asserted-by":"publisher","first-page":"8681","DOI":"10.1021\/acs.inorgchem.6b01241","volume":"55","author":"CN Banti","year":"2016","unstructured":"Banti CN, Papatriantafyllopoulou C, Manoli M, Tasiopoulos AJ, Hadjikakou SK (2016) Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; Anticancer activity against human breast cancer cells. Inorg Chem 55:8681\u20138696. https:\/\/doi.org\/10.1021\/acs.inorgchem.6b01241","journal-title":"Inorg Chem"},{"key":"10014_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jinorgbio.2017.11.004","volume":"179","author":"MP Chrysouli","year":"2018","unstructured":"Chrysouli MP, Banti CN, Kourkoumelis N, Panayiotou N, Tasiopoulos AJ, Hadjikakou SK (2018) Chloro(triphenylphosphine)gold(I) a forefront reagent in gold chemistry as apoptotic agent for cancer cells. J Inorg Biochem 179:107\u2013120. https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.11.004","journal-title":"J Inorg Biochem"},{"key":"10014_CR11","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.3390\/ijms19072055","volume":"19","author":"GK Latsis","year":"2018","unstructured":"Latsis GK, Banti CN, Kourkoumelis N, Papatriantafyllopoulou C, Panagiotou N, Tasiopoulos A, Douvalis A, Kalampounias AG, Bakas T, Hadjikakou SK (2018) Poly organotin acetates against DNA with possible implementation on human breast cancer. Int J Mol Sci 19:2055\u20132072. https:\/\/doi.org\/10.3390\/ijms19072055","journal-title":"Int J Mol Sci"},{"key":"10014_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jinorgbio.2015.04.014","volume":"150","author":"EI Gkaniatsou","year":"2015","unstructured":"Gkaniatsou EI, Banti CN, Kourkoumelis N, Skoulika S, Manoli M, Tasiopoulos AJ, Hadjikakou SK (2015) Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: enhancement of their solubility and bioactivity by using the surfactant CTAB. J Inorg Biochem 150:108\u2013119. https:\/\/doi.org\/10.1016\/j.jinorgbio.2015.04.014","journal-title":"J Inorg Biochem"},{"key":"10014_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ica.2019.02.004","volume":"489","author":"NM Polychronis","year":"2019","unstructured":"Polychronis NM, Banti CN, Raptopoulou CP, Psycharis V, Kourkoumelis N, Hadjikakou SK (2019) Non steroidal anti-inflammatory drug (NSAIDs) in breast cancer chemotherapy; antimony(V) salicylate a DNA binder. Inorg Chim Acta 489:39\u201347. https:\/\/doi.org\/10.1016\/j.ica.2019.02.004","journal-title":"Inorg Chim Acta"},{"key":"10014_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1039\/c2mt20039b","volume":"4","author":"CN Banti","year":"2012","unstructured":"Banti CN, Giannoulis AD, Kourkoumelis N, Owczarzak AM, Poyraz M, Kubicki M, Charalabopoulos K, Hadjikakou SK (2012) Mixed ligand\u2013silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. Metallomics 4:545\u2013560. https:\/\/doi.org\/10.1039\/c2mt20039b","journal-title":"Metallomics"},{"key":"10014_CR15","doi-asserted-by":"publisher","first-page":"6848","DOI":"10.1039\/c3dt53175a","volume":"43","author":"CN Banti","year":"2014","unstructured":"Banti CN, Giannoulis AD, Kourkoumelis N, Owczarzak A, Kubicki M, Hadjikakou SK (2014) Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis. Dalton Trans 43:6848\u20136863. https:\/\/doi.org\/10.1039\/c3dt53175a","journal-title":"Dalton Trans"},{"key":"10014_CR16","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ica.2011.04.032","volume":"375","author":"M Poyraz","year":"2011","unstructured":"Poyraz M, Banti CN, Kourkoumelis N, Dokorou V, Manos MJ, Sim\u010di\u010d M, Goli\u010d-Grdadolnik S, Mavromoustakos T, Giannoulis AD, Verginadis II, Charalabopoulos K, Hadjikakou SK (2011) Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid. Inorg Chim Acta 375:114\u2013121. https:\/\/doi.org\/10.1016\/j.ica.2011.04.032","journal-title":"Inorg Chim Acta"},{"key":"10014_CR17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ica.2011.10.024","volume":"382","author":"GK Batsala","year":"2012","unstructured":"Batsala GK, Dokorou V, Kourkoumelis N, Manos MJ, Tasiopoulos AJ, Mavromoustakos T, Sim\u010di\u010d M, Goli\u010d-Grdadolnik S, Hadjikakou SK (2012) Copper(I)\/(II) or silver(I) salts towards 2-mercaptopyrimidine; An exploration of a chemical variability with possible biological implications. Inorg Chim Acta 382:146\u2013157. https:\/\/doi.org\/10.1016\/j.ica.2011.10.024","journal-title":"Inorg Chim Acta"},{"key":"10014_CR18","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1071\/C96036","volume":"50","author":"GA Bowmaker","year":"1997","unstructured":"Bowmaker GA, Hart RD, De Silva EN, Skelton BW, White AH (1997) Lewis-base adducts of Group 11 Metal(I) compounds. LXX synthesis, spectroscopy and structural systematics of 1:2 binuclear adducts of copper(I) halides with triphenylstibine, [(Ph3Sb)2Cu(-X)2Cu(SbPh3)2], X\u2009=\u2009Cl, Br, I. Aust J Chem 50:621\u2013626. https:\/\/doi.org\/10.1071\/C96036","journal-title":"Aust J Chem"},{"key":"10014_CR19","first-page":"356","volume":"18","author":"Q-F Zhang","year":"1999","unstructured":"Zhang Q-F, Zeng D-X, Xin X-Q, Wong W-T (1999) Solid state synthesis and structural characterization of binuclear Cu(I)-SbPh~3 Complex [Cu(SbPh3)2I]2. Jiegou Huaxue (Chin J Struct Chem) 18:356","journal-title":"Jiegou Huaxue (Chin J Struct Chem)"},{"key":"10014_CR20","doi-asserted-by":"publisher","first-page":"12248","DOI":"10.1021\/ic3014255","volume":"51","author":"K Paizanos","year":"2012","unstructured":"Paizanos K, Charalampou D, Kourkoumelis N, Kalpogiannaki D, Hadjiarapoglou L, Spanopoulou A, Lazarou K, Manos MJ, Tasiopoulos AJ, Kubicki M, Hadjikakou SK (2012) Synthesis and structural characterization of new Cu(I) complexes with the antithyroid drug 6-n-propyl-thiouracil. Study of the Cu(I)-catalyzed intermolecular cycloaddition of iodonium ylides towards benzo[b]furans with pharmaceutical implementations. Inorg Chem 51:12248\u201312259. https:\/\/doi.org\/10.1021\/ic3014255","journal-title":"Inorg Chem"},{"key":"10014_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/BF01182141","volume":"14","author":"AL Rheingold","year":"1984","unstructured":"Rheingold AL, Fountain ME (1984) Crystal and molecular structure of [(C6H5)3Sb]3CuCl\u00b7CHCl3. J Crystallogr Spectrosc Res 14:549. https:\/\/doi.org\/10.1007\/BF01182141","journal-title":"J Crystallogr Spectrosc Res"},{"key":"10014_CR22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0020-1693(00)95939-5","volume":"5","author":"WT Reichle","year":"1971","unstructured":"Reichle WT (1971) Preparation, physical properties and reactions of copper(I)-triphenyl-m complexes (M\u2009=\u2009P, As, Sb). Inorg Chim Acta 5:325\u2013332. https:\/\/doi.org\/10.1016\/S0020-1693(00)95939-5","journal-title":"Inorg Chim Acta"},{"key":"10014_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jphotobiol.2016.08.041","volume":"163","author":"V Tsiatouras","year":"2016","unstructured":"Tsiatouras V, Banti CN, Grze\u015bkiewicz AM, Rossos G, Kourkoumelis N, Kubicki M, Hadjikakou SK (2016) Structural, photolysis and biological studies of novel mixed metal Cu(I)-Sb(III) mixed ligand complexes. J Photochem Photobiol B 163:261\u2013268. https:\/\/doi.org\/10.1016\/j.jphotobiol.2016.08.041","journal-title":"J Photochem Photobiol B"},{"key":"10014_CR24","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.1021\/ja960582d","volume":"118","author":"Schleyer PvR","year":"1996","unstructured":"PvR Schleyer, Maerker C, Dransfeld A, Jiao H, Hommes NJRvE (1996) Nucleus-independent chemical shifts: a simple and efficient aromaticity probe. J Am Chem Soc 118:6317\u20136318. https:\/\/doi.org\/10.1021\/ja960582d","journal-title":"J Am Chem Soc"},{"key":"10014_CR25","doi-asserted-by":"publisher","first-page":"7251","DOI":"10.1002\/anie.200502678","volume":"44","author":"X Huang","year":"2005","unstructured":"Huang X, Zhai HJ, Kiran B, Wang LS (2005) Observation of d-orbital aromaticity. Angew Chem 44:7251\u20137254. https:\/\/doi.org\/10.1002\/anie.200502678","journal-title":"Angew Chem"},{"key":"10014_CR26","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/cyto.a.20357","volume":"71A","author":"M Kajstura","year":"2007","unstructured":"Kajstura M, Dorota Halicka H, Pryjma J, Darzynkiewicz Z (2007) Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete \u201csub-G1\u201d peaks on DNA content histograms. Cytom A 71A:125\u2013131. https:\/\/doi.org\/10.1002\/cyto.a.20357","journal-title":"Cytom A"},{"key":"10014_CR27","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1021\/acs.molpharmaceut.5b00314","volume":"12","author":"Y Gou","year":"2015","unstructured":"Gou Y, Qi J, Ajayi J-P, Zhang Y, Zhou Z, Wu X, Yang F, Liang H (2015) Developing anticancer copper(II) pro-drugs based on the nature of cancer cells and the human serum albumin carrier IIA subdomain. Mol Pharm 12:3597\u20133609. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.5b00314","journal-title":"Mol Pharm"},{"key":"10014_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/emm.1998.25","volume":"30","author":"S-H Lee","year":"1998","unstructured":"Lee S-H, Kim D-K, Seo Y-R, Woo K-M, Kim C-S, Cho M-H (1998) Nickel(II)-induced apoptosis and G2\/M enrichment. Exp Mol Med 30:171\u2013176. https:\/\/doi.org\/10.1038\/emm.1998.25","journal-title":"Exp Mol Med"},{"key":"10014_CR29","doi-asserted-by":"publisher","first-page":"26553","DOI":"10.1074\/jbc.M202040200","volume":"277","author":"EA Kohn","year":"2002","unstructured":"Kohn EA, Ruth ND, Kay Brown M, Livingstone M, Eastman A (2002) Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7 hydroxystaurosporine and the kinetics of Cdc25C activation. J Biol Chem 277:26553\u201326564. https:\/\/doi.org\/10.1074\/jbc.M202040200","journal-title":"J Biol Chem"},{"key":"10014_CR30","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1093\/nar\/gkv467","volume":"43","author":"R Galindo-Murillo","year":"2015","unstructured":"Galindo-Murillo R, Carlos Garc\u0131a-Ramos J, Ruiz-Azuara L, Cheatham TE, Cortes-Guzman F (2015) Intercalation processes of copper complexes in DNA. Nucl Acids Res 43:5364\u20135376. https:\/\/doi.org\/10.1093\/nar\/gkv467","journal-title":"Nucl Acids Res"},{"key":"10014_CR31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jinorgbio.2016.11.007","volume":"166","author":"J Serment-Guerrero","year":"2017","unstructured":"Serment-Guerrero J, Elena Bravo-Gomez M, Lara-Rivera E, Ruiz-Azuara L (2017) Genotoxic assessment of the copper chelated compounds Casiopeinas: clues about their mechanisms of action. J Inorg Biochem 166:68\u201375. https:\/\/doi.org\/10.1016\/j.jinorgbio.2016.11.007","journal-title":"J Inorg Biochem"},{"key":"10014_CR32","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.ejmech.2017.10.067","volume":"143","author":"CN Banti","year":"2018","unstructured":"Banti CN, Papatriantafyllopoulou C, Tasiopoulos AJ, Hadjikakou SK (2018) New metalo-therapeutics of NSAIDs against human breast cancer cells. Eur J Med Chem 143:1687\u20131701. https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.067","journal-title":"Eur J Med Chem"},{"key":"10014_CR33","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1039\/C8CS00157J","volume":"48","author":"A Kellett","year":"2019","unstructured":"Kellett A, Molphy Z, Slator C, McKee V, Farrell NP (2019) Molecular methods for assessment of non-covalent metallodrug\u2013DNA interactions. Chem Soc Rev 48:971\u2013988. https:\/\/doi.org\/10.1039\/C8CS00157J","journal-title":"Chem Soc Rev"},{"key":"10014_CR34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jinorgbio.2009.10.020","volume":"104","author":"D-D Li","year":"2010","unstructured":"Li D-D, Tian J-L, Gu W, Liu X, Yan S-P (2010) A novel 1,2,4-triazole-based copper(II) complex: synthesis, characterization, magnetic property and nuclease activity. J Inorg Biochem 104:171\u2013179. https:\/\/doi.org\/10.1016\/j.jinorgbio.2009.10.020","journal-title":"J Inorg Biochem"},{"key":"10014_CR35","doi-asserted-by":"publisher","DOI":"10.1039\/b809873p","author":"DR Boer","year":"2009","unstructured":"Boer DR, Canals A, Coll M (2009) DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes. Dalton Trans. https:\/\/doi.org\/10.1039\/b809873p","journal-title":"Dalton Trans"},{"key":"10014_CR36","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/cr400135x","volume":"114","author":"C Santini","year":"2014","unstructured":"Santini C, Pellei M, Gandin V, Porchia M, Tisato F, Marzano C (2014) Advances in copper complexes as anticancer agents. Chem Rev 114:815\u2013862. https:\/\/doi.org\/10.1021\/cr400135x","journal-title":"Chem Rev"},{"key":"10014_CR37","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.3390\/ijms20153663","volume":"20","author":"A Wawruszak","year":"2019","unstructured":"Wawruszak A, Luszczki JJ, Kalafut J, Okla K, Halasa M, RiveroMuller A, Stepulak A (2019) Additive pharmacological interaction between cisplatin (CDDP) and histone deacetylase inhibitors (HDIs) in MDA-MB-231 triple negative breast cancer (TNBC) cells with altered Notch1 activity\u2014an isobolographic analysis. Int J Mol Sci 20:3663\u20133679. https:\/\/doi.org\/10.3390\/ijms20153663","journal-title":"Int J Mol Sci"},{"key":"10014_CR38","volume-title":"CrysAlis CCD and CrysAlis RED","author":"Oxford Diffraction","year":"2008","unstructured":"Diffraction Oxford (2008) CrysAlis CCD and CrysAlis RED. Oxford Diffraction Ltd., Abingdon"},{"key":"10014_CR39","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1107\/S002188980403225X","volume":"38","author":"MC Burla","year":"2005","unstructured":"Burla MC, Caliandro R, Camalli M, Carrozzini B, Cascarano GL, De Caro L, Giacovazzo C, Polidori G, Spagna R (2005) SIR2004: an improved tool for crystal structure determination and refinement. J Appl Cryst 38:381\u2013388. https:\/\/doi.org\/10.1107\/S002188980403225X","journal-title":"J Appl Cryst"},{"key":"10014_CR40","volume-title":"SHELXL-2014\/7, program for refinement of crystal structures","author":"GM Sheldrick","year":"2014","unstructured":"Sheldrick GM (2014) SHELXL-2014\/7, program for refinement of crystal structures. University of G\u00f6ttingen, G\u00f6ttingen"},{"key":"10014_CR41","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1107\/S0021889899006020","volume":"32","author":"LJ Farrugia","year":"1999","unstructured":"Farrugia LJ (1999) WinGX suite for small-molecule single-crystal crystallography. J Appl Cryst 32:837\u2013838. https:\/\/doi.org\/10.1107\/S0021889899006020","journal-title":"J Appl Cryst"},{"key":"10014_CR42","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.21769\/BioProtoc.3311","volume":"9","author":"CN Banti","year":"2019","unstructured":"Banti CN, Hadjikakou SK (2019) Evaluation of genotoxicity by micronucleus assay in vitro and by Allium cepa test in vivo. Bio-Protocol 9:3311. https:\/\/doi.org\/10.21769\/BioProtoc.3311","journal-title":"Bio-Protocol"},{"key":"10014_CR43","volume-title":"Gaussian 03, Revision C.02","author":"MJ Frisch","year":"2004","unstructured":"Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Montgomery JA Jr, Vreven T, Kudin KN, Burant JC, Millam JM, Iyengar SS, Tomasi J, Barone V, Mennucci B, Cossi M, Scalmani G, Rega N, Petersson GA, Nakatsuji H, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Klene M, Li X, Knox JE, Hratchian HP, Cross JB, Bakken V, Adamo C, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Ayala PY, Morokuma K, Voth GA, Salvador P, Dannenberg JJ, Zakrzewski VG, Dapprich S, Daniels AD, Strain MC, Farkas O, Malick DK, Rabuck AD, Raghavachari K, Foresman JB, Ortiz JV, Cui Q, Baboul AG, Clifford S, Cioslowski J, Stefanov BB, Liu G, Liashenko A, Piskorz P, Komaromi I, Martin RL, Fox DJ, Keith T, Al-Laham MA, Peng CY, Nanayakkara A, Challacombe M, Gill PMW, Johnson B, Chen W, Wong MW, Gonzalez C, Pople JA (2004) Gaussian 03, Revision C.02. Gaussian, Wallingford"},{"key":"10014_CR44","doi-asserted-by":"publisher","first-page":"15194","DOI":"10.1073\/pnas.95.26.15194","volume":"95","author":"H Rozenberg","year":"1998","unstructured":"Rozenberg H, Rabinovich D, Frolow F, Hegde RS, Shakked Z (1998) Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets. Proc Natl Acad Sci USA 95:15194\u201315199. https:\/\/doi.org\/10.1073\/pnas.95.26.15194","journal-title":"Proc Natl Acad Sci USA"},{"key":"10014_CR45","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455\u2013461. https:\/\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-019-10014-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11030-019-10014-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-019-10014-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T01:08:55Z","timestamp":1604970535000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11030-019-10014-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10014"],"URL":"https:\/\/doi.org\/10.1007\/s11030-019-10014-z","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,11]]},"assertion":[{"value":"25 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}