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It has many pharmacological activities such as anti-inflammatory and immune regulation.\n This paper aims to preliminarily explore the potential mechanism of piperine in the treatment of sciatica through network pharmacology and molecular docking. TCMSP, ETCM database and literature mining were used to collect the active compounds of <jats:italic>Piper longum<\/jats:italic> L. Swiss TargetPrediction and SuperPred server were used to find the targets of compounds. At the same time, CTD database was used to collect the targets of sciatica. Then the above targets were compared and analyzed to select the targets of anti-sciatica in <jats:italic>Piper longum<\/jats:italic> L. The Go (gene ontology) annotation and KEGG pathway of the targets were enriched and analyzed by Metascape database platform. The molecular docking between the effective components and the targets was verified by Autodock. After that, the sciatica model of rats was established and treated with piperine. The expression level of inflammatory factors and proteins in the serum and tissues of rat sciatic nerve were detected by ELISA and Western blot. HE staining and immunohistochemistry were carried out on the sciatica tissues of rats. The results showed that <jats:italic>Piper longum<\/jats:italic> L. can regulate the development of sciatica and affect the expressions of PPARG and NF-kB1 through its active ingredient piperine, and there is endogenous interaction between PPARG and NF-kB1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11030-020-10055-9","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T06:12:50Z","timestamp":1583302370000},"page":"233-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology"],"prefix":"10.1007","volume":"25","author":[{"given":"Jiu-wang","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-7156","authenticated-orcid":false,"given":"Li-dao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leng-ge","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"issue":"1","key":"10055_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00701-019-04117-7","volume":"162","author":"N Djuric","year":"2019","unstructured":"Djuric N, Yang X, El Barzouhi A, Ostelo R (2019) Lumbar disc extrusions reduce faster than bulging discs due to an active role of macrophages in sciatica. 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