{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:12:18Z","timestamp":1791148338485,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["121276"],"award-info":[{"award-number":["121276"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s11030-020-10112-3","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T03:02:25Z","timestamp":1591498945000},"page":"2201-2218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Synthesis, antimicrobial evaluation, and in silico studies of quinoline\u20141H-1,2,3-triazole molecular hybrids"],"prefix":"10.1007","volume":"25","author":[{"given":"Paul","family":"Awolade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosipho","family":"Cele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraju","family":"Kerru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"issue":"7586","key":"10112_CR1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature17042","volume":"529","author":"ED Brown","year":"2016","unstructured":"Brown ED, Wright GD (2016) Antibacterial drug discovery in the resistance era. Nature 529(7586):336\u2013343. https:\/\/doi.org\/10.1038\/nature17042","journal-title":"Nature"},{"issue":"7","key":"10112_CR2","doi-asserted-by":"publisher","first-page":"e1003467","DOI":"10.1371\/journal.ppat.1003467","volume":"9","author":"DM Morens","year":"2013","unstructured":"Morens DM, Fauci AS (2013) Emerging infectious diseases: threats to human health and global stability. PLoS Pathog 9(7):e1003467. https:\/\/doi.org\/10.1371\/journal.ppat.1003467","journal-title":"PLoS Pathog"},{"key":"10112_CR3","doi-asserted-by":"crossref","unstructured":"Lesho EP, Laguio-Vila M (2019) The slow-motion catastrophe of antimicrobial resistance and practical interventions for all prescribers. In: Mayo Clinic proceedings. Elsevier","DOI":"10.1016\/j.mayocp.2018.11.005"},{"issue":"5","key":"10112_CR4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/17460441.2017.1308351","volume":"12","author":"GE Croston","year":"2017","unstructured":"Croston GE (2017) The utility of target-based discovery. Expert Opin Drug Dis 12(5):427\u2013429. https:\/\/doi.org\/10.1080\/17460441.2017.1308351","journal-title":"Expert Opin Drug Dis"},{"key":"10112_CR5","series-title":"Royal society of chemistry","volume-title":"Designing multi-target drugs","year":"2012","unstructured":"Morphy JR, Harris CJ (eds) (2012) Designing multi-target drugs, vol 21. Royal society of chemistry. RSC Drug Discovery, Cambridge"},{"key":"10112_CR6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.ejmech.2016.08.039","volume":"124","author":"MS Shaveta","year":"2016","unstructured":"Shaveta MS, Singh P (2016) Hybrid molecules: the privileged scaffolds for various pharmaceuticals. Eur J Med Chem 124:500\u2013536. https:\/\/doi.org\/10.1016\/j.ejmech.2016.08.039","journal-title":"Eur J Med Chem"},{"key":"10112_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ejmech.2019.02.055","volume":"168","author":"B Zhang","year":"2019","unstructured":"Zhang B (2019) Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. Eur J Med Chem 168:357\u2013372. https:\/\/doi.org\/10.1016\/j.ejmech.2019.02.055","journal-title":"Eur J Med Chem"},{"key":"10112_CR8","doi-asserted-by":"publisher","first-page":"111700","DOI":"10.1016\/j.ejmech.2019.111700","volume":"183","author":"Z Xu","year":"2019","unstructured":"Xu Z, Zhao SJ, Liu Y (2019) 1,2,3-Triazole-containing hybrids as potential anticancer agents: current developments, action mechanisms and structure-activity relationships. Eur J Med Chem 183:111700. https:\/\/doi.org\/10.1016\/j.ejmech.2019.111700","journal-title":"Eur J Med Chem"},{"issue":"6","key":"10112_CR9","doi-asserted-by":"publisher","first-page":"6912","DOI":"10.1021\/acsomega.8b00582","volume":"3","author":"B Aneja","year":"2018","unstructured":"Aneja B, Azam M, Alam S, Perwez A, Maguire R, Yadava U, Kavanagh K, Daniliuc CG, Rizvi MMA, Haq QMR (2018) Natural product-based 1, 2, 3-triazole\/sulfonate analogues as potential chemotherapeutic agents for bacterial infections. ACS Omega 3(6):6912\u20136930. https:\/\/doi.org\/10.1021\/acsomega.8b00582","journal-title":"ACS Omega"},{"issue":"10","key":"10112_CR10","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.drudis.2017.05.014","volume":"22","author":"E Bonandi","year":"2017","unstructured":"Bonandi E, Christodoulou MS, Fumagalli G, Perdicchia D, Rastelli G, Passarella D (2017) The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. Drug Discov Today 22(10):1572\u20131581. https:\/\/doi.org\/10.1016\/j.drudis.2017.05.014","journal-title":"Drug Discov Today"},{"issue":"4","key":"10112_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0175710","volume":"12","author":"M Irfan","year":"2017","unstructured":"Irfan M, Alam S, Manzoor N, Abid M (2017) Effect of quinoline based 1,2,3-triazole and its structural analogues on growth and virulence attributes of Candida albicans. PLoS ONE 12(4):1\u201323. https:\/\/doi.org\/10.1371\/journal.pone.0175710","journal-title":"PLoS ONE"},{"key":"10112_CR12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ejmech.2015.02.007","volume":"93","author":"M Irfan","year":"2015","unstructured":"Irfan M, Aneja B, Yadava U, Khan SI, Manzoor N, Daniliuc CG, Abid M (2015) Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. Eur J Med Chem 93:246\u2013254. https:\/\/doi.org\/10.1016\/j.ejmech.2015.02.007","journal-title":"Eur J Med Chem"},{"issue":"16","key":"10112_CR13","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1016\/j.bmcl.2017.07.023","volume":"27","author":"Z Xu","year":"2017","unstructured":"Xu Z, Zhang S, Song X, Qiang M, Lv Z (2017) Design, synthesis and in vitro anti-mycobacterial evaluation of gatifloxacin-1H-1, 2, 3-triazole-isatin hybrids. Bioorg Med Chem Lett 27(16):3643\u20133646. https:\/\/doi.org\/10.1016\/j.bmcl.2017.07.023","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10112_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/jhet","volume":"55","author":"Z Xu","year":"2017","unstructured":"Xu Z, Lv ZS, Song XF, Qiang M (2017) Ciprofloxacin-isatin-1H-1,2,3-triazole hybrids: design, synthesis, and in vitro anti-tubercular activity against M. Tuberculosis. J Heterocycl Chem 55(1):97\u2013102. https:\/\/doi.org\/10.1002\/jhet","journal-title":"J Heterocycl Chem"},{"key":"10112_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ejmech.2016.02.041","volume":"113","author":"R Kant","year":"2016","unstructured":"Kant R, Kumar D, Agarwal D, Gupta RD, Tilak R, Awasthi SK, Agarwal A (2016) Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. Eur J Med Chem 113:34\u201349. https:\/\/doi.org\/10.1016\/j.ejmech.2016.02.041","journal-title":"Eur J Med Chem"},{"key":"10112_CR16","doi-asserted-by":"publisher","first-page":"103162","DOI":"10.1016\/j.bioorg.2019.103162","volume":"91","author":"F Gao","year":"2019","unstructured":"Gao F, Ye L, Kong F, Huang G, Xiao J (2019) Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids. Bioorg Chem 91:103162. https:\/\/doi.org\/10.1016\/j.bioorg.2019.103162","journal-title":"Bioorg Chem"},{"key":"10112_CR17","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.ejmech.2019.07.057","volume":"180","author":"F Gao","year":"2019","unstructured":"Gao F, Chen Z, Ma L, Fan Y, Chen L, Lu G (2019) Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. Eur J Med Chem 180:648\u2013655. https:\/\/doi.org\/10.1016\/j.ejmech.2019.07.057","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10112_CR18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1039\/c4md00284a","volume":"6","author":"X Song Yn","year":"2015","unstructured":"Song Yn X, Chen W, Zhan P, Liu X (2015) 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential. MedChemComm 6(1):61\u201374. https:\/\/doi.org\/10.1039\/c4md00284a","journal-title":"MedChemComm"},{"key":"10112_CR19","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ejmech.2016.05.007","volume":"120","author":"V Oliveri","year":"2016","unstructured":"Oliveri V, Vecchio G (2016) 8-Hydroxyquinolines in medicinal chemistry: a structural perspective. Eur J Med Chem 120:252\u2013274. https:\/\/doi.org\/10.1016\/j.ejmech.2016.05.007","journal-title":"Eur J Med Chem"},{"key":"10112_CR20","doi-asserted-by":"publisher","first-page":"111921","DOI":"10.1016\/j.ejmech.2019.111921","volume":"187","author":"P Awolade","year":"2020","unstructured":"Awolade P, Cele N, Kerru N, Gummidi L, Oluwakemi E, Singh P (2020) Therapeutic significance of \u03b2-glucuronidase activity and its inhibitors: a review. Eur J Med Chem 187:111921. https:\/\/doi.org\/10.1016\/j.ejmech.2019.111921","journal-title":"Eur J Med Chem"},{"key":"10112_CR21","unstructured":"CLH (2014) CLH report for 8-hydroxyquinoline"},{"key":"10112_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/cbdd.13632","volume":"95","author":"O Ebenezer","year":"2020","unstructured":"Ebenezer O, Awolade P, Koorbanally N, Singh P (2020) New library of pyrazole-imidazo[1,2-\u03b1]pyridine molecular conjugates: synthesis, antibacterial activity and molecular docking studies. Chem Biol Drug Des 95:162\u2013173. https:\/\/doi.org\/10.1111\/cbdd.13632","journal-title":"Chem Biol Drug Des"},{"key":"10112_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-020-10046-w","author":"O Ebenezer","year":"2020","unstructured":"Ebenezer O, Singh-Pillay A, Koorbanally NA, Singh P (2020) Antibacterial evaluation and molecular docking studies of pyrazole\u2013thiosemicarbazones and their pyrazole\u2013thiazolidinone conjugates. Mol Divers. https:\/\/doi.org\/10.1007\/s11030-020-10046-w","journal-title":"Mol Divers"},{"issue":"1\u20132","key":"10112_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.molcata.2006.11.002","volume":"267","author":"B Das","year":"2007","unstructured":"Das B, Venkateswarlu K, Majhi A, Siddaiah V, Reddy KR (2007) A facile nuclear bromination of phenols and anilines using NBS in the presence of ammonium acetate as a catalyst. J Mol Catal A Chem 267(1\u20132):30\u201333. https:\/\/doi.org\/10.1016\/j.molcata.2006.11.002","journal-title":"J Mol Catal A Chem"},{"issue":"8","key":"10112_CR25","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1021\/jacs.6b12745","volume":"139","author":"JY Lim","year":"2017","unstructured":"Lim JY, Marques I, Thompson AL, Christensen KE, Felix V, Beer PD (2017) Chalcogen bonding macrocycles and [2]rotaxanes for anion recognition. J Am Chem Soc 139(8):3122\u20133133. https:\/\/doi.org\/10.1021\/jacs.6b12745","journal-title":"J Am Chem Soc"},{"issue":"1","key":"10112_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1039\/C6MT00172F","volume":"9","author":"ME Helsel","year":"2017","unstructured":"Helsel ME, White EJ, Razvi SZA, Alies B, Franz KJ (2017) Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. Metallomics 9(1):69\u201381. https:\/\/doi.org\/10.1039\/C6MT00172F","journal-title":"Metallomics"},{"key":"10112_CR27","volume-title":"Drug-like properties: concepts, structure design and methods: from ADME to toxicity optimization","author":"EH Kerns","year":"2008","unstructured":"Kerns EH, Di L (2008) Drug-like properties: concepts, structure design and methods: from ADME to toxicity optimization, 1st edn. Elsevier, Amsterdam","edition":"1"},{"key":"10112_CR28","volume-title":"QikProp, version 6.0","author":"QikProp","year":"2019","unstructured":"QikProp (2019) QikProp, version 6.0. Schr\u00f6dinger, LLC, New York"},{"issue":"4","key":"10112_CR29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1021\/ci3006098","volume":"53","author":"ML Hall","year":"2013","unstructured":"Hall ML, Jorgensen WL, Whitehead L (2013) Automated ligand- and structure-based protocol for in silico prediction of human serum albumin binding. J Chem Inf Model 53(4):907\u2013922. https:\/\/doi.org\/10.1021\/ci3006098","journal-title":"J Chem Inf Model"},{"issue":"3","key":"10112_CR30","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1152\/physrev.00036.2011","volume":"92","author":"JI Vandenberg","year":"2012","unstructured":"Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP (2012) hERG K(+) channels: structure, function, and clinical significance. Physiol Rev 92(3):1393\u20131478. https:\/\/doi.org\/10.1152\/physrev.00036.2011","journal-title":"Physiol Rev"},{"issue":"7","key":"10112_CR31","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.drudis.2018.05.020","volume":"23","author":"J Hering","year":"2018","unstructured":"Hering J, Dunevall E, Ek M, Branden G (2018) Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis. Drug Discov Today 23(7):1426\u20131435. https:\/\/doi.org\/10.1016\/j.drudis.2018.05.020","journal-title":"Drug Discov Today"},{"issue":"8","key":"10112_CR32","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1128\/AAC.00925-15","volume":"59","author":"AA Sagatova","year":"2015","unstructured":"Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD (2015) Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14\u03b1-demethylase. Antimicrob Agents Chemother 59(8):4982\u20134989. https:\/\/doi.org\/10.1128\/AAC.00925-15","journal-title":"Antimicrob Agents Chemother"},{"key":"10112_CR33","volume-title":"PrimeX version 5.6","author":"PrimeX","year":"2019","unstructured":"PrimeX (2019) PrimeX version 5.6. Schr\u00f6dinger, LLC, New York"},{"key":"10112_CR34","unstructured":"Protein Preparation Wizard (2019) Protein Preparation Wizard; Epik, Schr\u00f6dinger, LLC, New York, NY, 2019; Impact, Schr\u00f6dinger, LLC, New York, NY, 2019; Prime, Schr\u00f6dinger, LLC, New York, NY, 2019"},{"key":"10112_CR35","unstructured":"Induced Fit Docking Protocol (2019) Induced Fit Docking protocol; Glide, Schr\u00f6dinger, LLC, New York, NY, 2019; Prime, Schr\u00f6dinger, LLC, New York, NY. 2019"},{"key":"10112_CR36","unstructured":"LigPrep, Schr\u00f6dinger, LLC, New York, NY. 2019. (2019)"},{"key":"10112_CR37","unstructured":"Epik, Schr\u00f6dinger, LLC, New York, NY. 2019. (2019)"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-020-10112-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-020-10112-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-020-10112-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T12:26:03Z","timestamp":1635337563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-020-10112-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10112"],"URL":"https:\/\/doi.org\/10.1007\/s11030-020-10112-3","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,7]]},"assertion":[{"value":"3 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethics approval for the hemolysis assay is The University of Queensland Institutional Human Research Ethics Approval approved by the Medical Research Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}