{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:12:39Z","timestamp":1777507959453,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s11030-021-10199-2","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:03:58Z","timestamp":1614593038000},"page":"869-878","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mechanistic insight of cell anti-proliferative activity of fluoroquinolone drug-based Cu(II) complexes"],"prefix":"10.1007","volume":"26","author":[{"given":"Divyang H.","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foram U.","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandramani","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar N.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-3226","authenticated-orcid":false,"given":"Bhupesh S.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"issue":"5","key":"10199_CR1","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1021\/cr068207j","volume":"107","author":"Y Jung","year":"2007","unstructured":"Jung Y, Lippard SJ (2007) Direct cellular responses to platinum-induced DNA damage. Chem Rev 107(5):1387\u20131407","journal-title":"Chem Rev"},{"issue":"11","key":"10199_CR2","doi-asserted-by":"publisher","first-page":"e4523","DOI":"10.1002\/aoc.4523","volume":"32","author":"KP Thakor","year":"2018","unstructured":"Thakor KP, Lunagariya MV, Bhatt BS, Patel MN (2018) Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds. Appl Organomet Chem 32(11):e4523","journal-title":"Appl Organomet Chem"},{"issue":"7","key":"10199_CR3","doi-asserted-by":"publisher","first-page":"e4386","DOI":"10.1002\/aoc.4386","volume":"32","author":"WH Mahmoud","year":"2018","unstructured":"Mahmoud WH, Omar M, Sayed FN, Mohamed GG (2018) Synthesis, characterization, spectroscopic and theoretical studies of transition metal complexes of new nano Schiff base derived from l-histidine and 2-acetylferrocene and evaluation of biological and anticancer activities. Appl Organomet Chem 32(7):e4386","journal-title":"Appl Organomet Chem"},{"issue":"10","key":"10199_CR4","doi-asserted-by":"publisher","first-page":"e5152","DOI":"10.1002\/aoc.5152","volume":"33","author":"PA Vekariya","year":"2019","unstructured":"Vekariya PA, Karia PS, Bhatt BS, Patel MN (2019) Spectroscopic and electrochemical study for evaluating DNA interaction activity of 4-(3-halophenyl)-6-(pyridin-2-yl) pyrimidin-2-amine based piano stool Cp* Rh (III) and Ir (III) complexes. Appl Organomet Chem 33(10):e5152","journal-title":"Appl Organomet Chem"},{"issue":"1","key":"10199_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11030-018-09909-0","volume":"24","author":"CN Banti","year":"2020","unstructured":"Banti CN, Poyraz M, Sainis I, Sari M, Rossos G, Kourkoumelis N, Hadjikakou SK (2020) The periodic table of urea derivative: small molecules of zinc(II) and nickel(II) of diverse antimicrobial and antiproliferative applications. Mol Diversity 24(1):31\u201343. https:\/\/doi.org\/10.1007\/s11030-018-09909-0","journal-title":"Mol Diversity"},{"issue":"2","key":"10199_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11030-018-9878-4","volume":"23","author":"YP Singh","year":"2019","unstructured":"Singh YP, Pandey A, Vishwakarma S, Modi G (2019) A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer\u2019s and Parkinson\u2019s diseases. Mol Diversity 23(2):509\u2013526. https:\/\/doi.org\/10.1007\/s11030-018-9878-4","journal-title":"Mol Diversity"},{"issue":"4","key":"10199_CR7","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s11030-019-10014-z","volume":"24","author":"CN Banti","year":"2020","unstructured":"Banti CN, Tsiatouras V, Karanicolas K, Panagiotou N, Tasiopoulos AJ, Kourkoumelis N, Hadjikakou SK (2020) Antiproliferative activity and apoptosis induction, of organo-antimony(III)\u2013copper(I) conjugates, against human breast cancer cells. Mol Diversity 24(4):1095\u20131106. https:\/\/doi.org\/10.1007\/s11030-019-10014-z","journal-title":"Mol Diversity"},{"issue":"4","key":"10199_CR8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495\u2013516","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10199_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.canlet.2008.07.001","volume":"275","author":"JF Whitfield","year":"2009","unstructured":"Whitfield JF (2009) Calcium, calcium-sensing receptor and colon cancer. Cancer Lett 275(1):9\u201316","journal-title":"Cancer Lett"},{"key":"10199_CR10","doi-asserted-by":"crossref","unstructured":"Sol\u00eds-Ruiz JA, Barthe A, Riegel G, Saavedra-D\u00edaz RO, Gaiddon C, Le Lagadec R (2020) Light activation of cyclometalated ruthenium complexes drives towards caspase 3 dependent apoptosis in gastric cancer cells. J Inorg Biochem, p 111080","DOI":"10.1016\/j.jinorgbio.2020.111080"},{"key":"10199_CR11","doi-asserted-by":"crossref","unstructured":"Parsa FG, Feizi MAH, Safaralizadeh R, Hosseini-Yazdi SA, Mahdavi M (2020) Molecular mechanisms of apoptosis induction in K562 and KG1a leukemia cells by a water-soluble copper (II) thiosemicarbazone complex. J Biol Inorg Chem JBIC a Publ Soc Biol Inorg Chem","DOI":"10.1007\/s00775-020-01769-0"},{"issue":"5","key":"10199_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/10601325.2017.1294449","volume":"54","author":"N Tekin","year":"2017","unstructured":"Tekin N, \u00d6zt\u00fcrk K, Baran T, Kerimo\u011flu B, Tarhan M, Mente\u015f A (2017) Cytotoxic and apoptotic activities of novel Pd (II) complexes against human leukemia cell lines in vitro. J Macromol Sci Part A 54(5):263\u2013270","journal-title":"J Macromol Sci Part A"},{"issue":"2","key":"10199_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00775-016-1335-1","volume":"21","author":"AN Besold","year":"2016","unstructured":"Besold AN, Culbertson EM, Culotta VC (2016) The Yin and Yang of copper during infection. J Biol Inorg Chem 21(2):137\u2013144","journal-title":"J Biol Inorg Chem"},{"key":"10199_CR14","volume-title":"Biochemistry of copper","author":"MC Linder","year":"2013","unstructured":"Linder MC (2013) Biochemistry of copper, vol 10. Springer, Berlin"},{"key":"10199_CR15","doi-asserted-by":"crossref","unstructured":"Iakovidis I, Delimaris I, Piperakis SM (2011) Copper and its complexes in medicine: a biochemical approach. Mol Biol Int","DOI":"10.4061\/2011\/594529"},{"issue":"4A","key":"10199_CR16","first-page":"395","volume":"82","author":"H Neu","year":"1987","unstructured":"Neu H (1987) Ciprofloxacin: an overview and prospective appraisal. Am J Med 82(4A):395\u2013404","journal-title":"Am J Med"},{"issue":"4","key":"10199_CR17","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2165\/00003495-199958040-00010","volume":"58","author":"CM Perry","year":"1999","unstructured":"Perry CM, Balfour JAB, Lamb HM (1999) Gatifloxacin Drugs 58(4):683\u2013696","journal-title":"Gatifloxacin Drugs"},{"issue":"1","key":"10199_CR18","first-page":"49","volume":"54","author":"M Verma","year":"2004","unstructured":"Verma M, Pandeya SN, Singh KN, Stables JP (2004) Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharmaceutica 54(1):49\u201356","journal-title":"Acta Pharmaceutica"},{"issue":"1","key":"10199_CR19","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/zaac.201100307","volume":"638","author":"MN Patel","year":"2012","unstructured":"Patel MN, Bhatt BS, Dosi PA (2012) Spectroscopic study of DNA hydrolysis, DNA ntercalative, and electrostatic interaction activity exerted by drug based coordination compounds. Zeitschrift f\u00fcr anorganische und allgemeine Chemie 638(1):152\u2013162","journal-title":"Zeitschrift f\u00fcr anorganische und allgemeine Chemie"},{"key":"10199_CR20","doi-asserted-by":"crossref","unstructured":"Waghela BN, Sharma A, Dhumale S, Pandey SM, Pathak C (2015) Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells. PloS ONE, vol 10, no 221. Ranjan K, Sharma A, Surolia A, Pathak C (2014) Regulation of HA14\u20101 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. BioFactors 40 (1):157-169","DOI":"10.1002\/biof.1098"},{"issue":"1","key":"10199_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/biof.1098","volume":"40","author":"K Ranjan","year":"2014","unstructured":"Ranjan K, Sharma A, Surolia A, Pathak C (2014) Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. BioFactors 40(1):157\u2013169","journal-title":"BioFactors"},{"issue":"5","key":"10199_CR22","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/iub.1379","volume":"67","author":"SS Dhumale","year":"2015","unstructured":"Dhumale SS, Waghela BN, Pathak C (2015) Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB Life 67(5):361\u2013373","journal-title":"IUBMB Life"},{"issue":"1","key":"10199_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4489\/MYCO.2007.35.1.025","volume":"35","author":"MR Islam","year":"2007","unstructured":"Islam MR, Islam SR, Noman ASM, Khanam JA, Ali SMM, Alam S, Lee MW (2007) Biological screening of a novel nickel (II) tyrosine complex. Mycobiology 35(1):25\u201329","journal-title":"Mycobiology"},{"key":"10199_CR24","unstructured":"Mendham J (2006) Vogels textbook of quantitative chemical analysis. Pearson Education India"},{"issue":"9","key":"10199_CR25","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.poly.2004.02.028","volume":"23","author":"R Carballo","year":"2004","unstructured":"Carballo R, Castineiras A, Covelo B, Garc\u0131a-Mart\u0131nez E, Nicl\u00f3s J, V\u00e1zquez-L\u00f3pez E (2004) Solid state coordination chemistry of mononuclear mixed-ligand complexes of Ni (II), Cu (II) and Zn (II) with \u03b1-hydroxycarboxylic acids and imidazole. Polyhedron 23(9):1505\u20131518","journal-title":"Polyhedron"},{"issue":"3","key":"10199_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0010-8545(00)80455-5","volume":"33","author":"G Deacon","year":"1980","unstructured":"Deacon G, Phillips R (1980) Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination. Coord Chem Rev 33(3):227\u2013250","journal-title":"Coord Chem Rev"},{"issue":"8","key":"10199_CR27","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1021\/ed083p1229","volume":"83","author":"E Garribba","year":"2006","unstructured":"Garribba E, Micera G (2006) The determination of the geometry of Cu (II) complexes: an EPR spectroscopy experiment. J Chem Educ 83(8):1229","journal-title":"J Chem Educ"},{"issue":"1","key":"10199_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.saa.2005.04.030","volume":"63","author":"R Patel","year":"2006","unstructured":"Patel R, Singh N, Shukla K, Gundla V, Chauhan U (2006) Synthesis, characterization and biological activity of ternary copper (II) complexes containing polypyridyl ligands. Spectrochim Acta Part A Mol Biomol Spectrosc 63(1):21\u201326","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"issue":"5","key":"10199_CR29","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.ica.2007.08.026","volume":"361","author":"FA Mautner","year":"2008","unstructured":"Mautner FA, Vicente R, Louka FR, Massoud SS (2008) Dinuclear fumarato-and terephthalato-bridged copper (II) complexes: Structural characterization and magnetic properties. Inorg Chim Acta 361(5):1339\u20131348","journal-title":"Inorg Chim Acta"},{"issue":"2","key":"10199_CR30","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1248\/cpb.52.178","volume":"52","author":"UK Mazumder","year":"2004","unstructured":"Mazumder UK, Gupta M, Karki SS, Bhattacharya S, Rathinasamy S, Thangavel S (2004) Synthesis, anticancer and antibacterial activity of some novel mononuclear Ru (II) complexes. Chem Pharm Bull 52(2):178\u2013185","journal-title":"Chem Pharm Bull"},{"issue":"30","key":"10199_CR31","doi-asserted-by":"publisher","first-page":"16973","DOI":"10.1039\/C8RA00954F","volume":"8","author":"D Mahendiran","year":"2018","unstructured":"Mahendiran D, Amuthakala S, Bhuvanesh NS, Kumar RS, Rahiman AK (2018) Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest. RSC Adv 8(30):16973\u201316990","journal-title":"RSC Adv"},{"key":"10199_CR32","unstructured":"da Sesto VC (2005) Fluorine-A vital element in the medicine chest. Pharmaceuticals, p 26"},{"key":"10199_CR33","doi-asserted-by":"crossref","unstructured":"Chacon E, Acosta D, Lemasters JJ (1997) Primary cultures of cardiac myocytes as in vitro models for pharmacological and toxicological assessments. In: In vitro methods in pharmaceutical research. Elsevier, pp 209\u2013223","DOI":"10.1016\/B978-012163390-5.50010-7"},{"issue":"8","key":"10199_CR34","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3109\/00498254.2014.889333","volume":"44","author":"J Zhao","year":"2014","unstructured":"Zhao J, Wen Y, Zhang W, Zhao D, Fan A, Zhang Y, Deng S, Wang X, Liu Q, Lu Y (2014) Investigation on pharmacokinetics, tissue distribution and excretion of a novel platinum anticancer agent in rats by inductively coupled plasma mass spectrometry (ICP-MS). Xenobiotica 44(8):757\u2013762","journal-title":"Xenobiotica"},{"issue":"1","key":"10199_CR35","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1080\/21691401.2019.1569530","volume":"47","author":"H Liang","year":"2019","unstructured":"Liang H, Xu Y, Zhang Q, Yang Y, Mou Y, Gao Y, Chen R, Chen C, Dai P (2019) MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells. Artificial Cells Nanomed Biotechnol 47(1):725\u2013736","journal-title":"Artificial Cells Nanomed Biotechnol"},{"issue":"5","key":"10199_CR36","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1038\/nprot.2006.339","volume":"1","author":"F Na","year":"2006","unstructured":"Na F, Rodermond H, Stap J, Haveman J, van Bree C (2006) Clonogenic assay of cells in vitro. Nat Protoc 1(5):2315\u20132319","journal-title":"Nat Protoc"},{"issue":"1\u20132","key":"10199_CR37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0022-1759(00)00233-7","volume":"243","author":"I Vermes","year":"2000","unstructured":"Vermes I, Haanen C, Reutelingsperger C (2000) Flow cytometry of apoptotic cell death. J Immunol Methods 243(1\u20132):167\u2013190","journal-title":"J Immunol Methods"},{"key":"10199_CR38","doi-asserted-by":"crossref","unstructured":"Chan FK-M, Moriwaki K, De Rosa MJ (2013) Detection of necrosis by release of lactate dehydrogenase activity. In: Immune Homeostasis. Springer, pp 65\u201370","DOI":"10.1007\/978-1-62703-290-2_7"},{"issue":"81","key":"10199_CR39","doi-asserted-by":"publisher","first-page":"51162","DOI":"10.1039\/C7RA09102H","volume":"7","author":"S Zhi","year":"2017","unstructured":"Zhi S, Yu H, Mao R, Hu J, Song W, Zhang J (2017) Mitochondrial and nuclear DNA dual damage induced by 2-(2\u2032-quinolyl) benzimidazole copper complexes with potential anticancer activity. RSC Adv 7(81):51162\u201351174","journal-title":"RSC Adv"},{"issue":"1","key":"10199_CR40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/2231-4040.126999","volume":"5","author":"C Wu","year":"2014","unstructured":"Wu C (2014) An important player in brine shrimp lethality bioassay: The solvent. J Adv Pharmaceutical Technol Res 5(1):57","journal-title":"J Adv Pharmaceutical Technol Res"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-021-10199-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-021-10199-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-021-10199-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T01:52:41Z","timestamp":1724550761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-021-10199-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10199"],"URL":"https:\/\/doi.org\/10.1007\/s11030-021-10199-2","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"30 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}