{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:55:00Z","timestamp":1771534500813,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s11030-023-10767-8","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T11:02:56Z","timestamp":1702292576000},"page":"3497-3521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring Monkeypox: prospects for therapeutics through computational-aided drug discovery"],"prefix":"10.1007","volume":"28","author":[{"given":"Daniela Bermeo","family":"Grajales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supratik","family":"Kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"10767_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12172190","author":"E Gomez-Lucia","year":"2022","unstructured":"Gomez-Lucia E (2022) Monkeypox: some keys to understand this emerging disease. Animals. https:\/\/doi.org\/10.3390\/ani12172190","journal-title":"Animals"},{"key":"10767_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1076251","author":"S Rampogu","year":"2023","unstructured":"Rampogu S, Kim Y, Kim S-W, Lee KW (2023) An overview on monkeypox virus: pathogenesis, transmission, host interaction and therapeutics. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2023.1076251","journal-title":"Front Cell Infect Microbiol"},{"key":"10767_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/978-1-4899-7448-8_21","volume-title":"Viral infections of humans","author":"BW Petersen","year":"2014","unstructured":"Petersen BW, Damon IK, Bennett JE, Dolin R, Blaser MJ (2014) Mandell, Douglas, and Bennett\u2019s principles and practice of infectious diseases. In: Kaslow R, Stanberry L, Le Duc J (eds) Viral infections of humans, 8th edn. Springer, Boston, pp 501\u2013517. https:\/\/doi.org\/10.1007\/978-1-4899-7448-8_21","edition":"8"},{"key":"10767_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jiph.2023.02.003","volume":"16","author":"A Karagoz","year":"2023","unstructured":"Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlovi\u0107 S, \u0106ordi\u0107 S, Rabaan AA, Alsuhaimi E (2023) Monkeypox (mpox) virus: classification, origin, transmission, genome organization, antiviral drugs, and molecular diagnosis. J Infect Public Health 16:531\u2013541. https:\/\/doi.org\/10.1016\/j.jiph.2023.02.003","journal-title":"J Infect Public Health"},{"key":"10767_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/life13020522","author":"F Anwar","year":"2023","unstructured":"Anwar F, Haider F, Khan S, Ahmad I, Ahmed N, Imran M, Rashid S, Ren Z-G, Khattak S, Ji X-Y (2023) Clinical manifestation, transmission, pathogenesis, and diagnosis of monkeypox virus: a comprehensive review. Life. https:\/\/doi.org\/10.3390\/life13020522","journal-title":"Life"},{"key":"10767_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-023-00870-1","author":"JPS Begum","year":"2023","unstructured":"Begum JPS, Ngangom L, Semwal P, Painuli S, Sharma R, Gupta A (2023) Emergence of monkeypox: a worldwide public health crisis. Hum Cell. https:\/\/doi.org\/10.1007\/s13577-023-00870-1","journal-title":"Hum Cell"},{"key":"10767_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10122091","author":"AA Saied","year":"2022","unstructured":"Saied AA, Dhawan M, Metwally AA, Fahrni ML, Choudhary P, Choudhary OP (2022) Disease history, pathogenesis, diagnostics, and therapeutics for human monkeypox disease: a comprehensive review. Vaccines. https:\/\/doi.org\/10.3390\/vaccines10122091","journal-title":"Vaccines"},{"key":"10767_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1600-065X.2008.00691.x","volume":"225","author":"JR Weaver","year":"2008","unstructured":"Weaver JR, Isaacs SN (2008) Monkeypox virus and insights into its immunomodulatory proteins. Immunol Rev 225:96\u2013113. https:\/\/doi.org\/10.1111\/j.1600-065X.2008.00691.x","journal-title":"Immunol Rev"},{"key":"10767_CR9","doi-asserted-by":"publisher","unstructured":"Giorgi FM, Pozzobon D, Di Meglio A, Mercatelli D (2022) Genomic analysis of the recent monkeypox outbreak. bioRxiv https:\/\/doi.org\/10.1101\/2022.06.01.494368","DOI":"10.1101\/2022.06.01.494368"},{"key":"10767_CR10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41577-022-00775-4","volume":"22","author":"F-M Lum","year":"2022","unstructured":"Lum F-M, Torres-Ruesta A, Tay MZ, Lin RTP, Lye DC, R\u00e9nia L, Ng LFP (2022) Monkeypox: disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol 22:597\u2013613. https:\/\/doi.org\/10.1038\/s41577-022-00775-4","journal-title":"Nat Rev Immunol"},{"key":"10767_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04657-0","author":"M Thakur","year":"2023","unstructured":"Thakur M, Das P, Sobti RC, Kaur T (2023) Human monkeypox: epidemiology, transmission, pathogenesis, immunology, diagnosis and therapeutics. Mol Cell Biochem. https:\/\/doi.org\/10.1007\/s11010-022-04657-0","journal-title":"Mol Cell Biochem"},{"key":"10767_CR12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.26531","author":"J Kaler","year":"2022","unstructured":"Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D (2022) Monkeypox: a comprehensive review of transmission, pathogenesis, and manifestation. Cureus. https:\/\/doi.org\/10.7759\/cureus.26531","journal-title":"Cureus"},{"key":"10767_CR13","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/s41392-022-01215-4","volume":"7","author":"Y Huang","year":"2022","unstructured":"Huang Y, Mu L, Wang W (2022) Monkeypox: epidemiology, pathogenesis, treatment and prevention. Signal Transduct Target Ther 7:373. https:\/\/doi.org\/10.1038\/s41392-022-01215-4","journal-title":"Signal Transduct Target Ther"},{"key":"10767_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147866","author":"D Kmiec","year":"2022","unstructured":"Kmiec D, Kirchhoff F (2022) Monkeypox: a new threat? Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23147866","journal-title":"Int J Mol Sci"},{"key":"10767_CR15","first-page":"561","volume":"52","author":"CDC","year":"2003","unstructured":"CDC (2003) Update: multistate outbreak of Monkeypox-Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. Morb Mortal Wkly Rep 52:561\u2013564","journal-title":"Morb Mortal Wkly Rep"},{"key":"10767_CR16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3201\/eid1003.030878","volume":"10","author":"Guarner, J, Johnson, BJ, Paddock, CD, Shieh, W-J, Goldsmith, CS, Reynolds, MG, Damon, IK, Regnery, RL, Zaki, SR, & Group, VMVW","year":"2004","unstructured":"Guarner, J, Johnson, BJ, Paddock, CD, Shieh, W-J, Goldsmith, CS, Reynolds, MG, Damon, IK, Regnery, RL, Zaki, SR, & Group, VMVW (2004) Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis 10:426\u2013431. https:\/\/doi.org\/10.3201\/eid1003.030878","journal-title":"Emerg Infect Dis"},{"key":"10767_CR17","unstructured":"WHO (2023) 2022\u201323 Mpox (Monkeypox) outbreak: global trends. World Health Organization https:\/\/www.who.int\/emergencies\/situations\/monkeypox-oubreak-2022"},{"key":"10767_CR18","unstructured":"CDC (2023) 2022 outbreak cases and data. Centers for Disease Control & Prevention https:\/\/www.cdc.gov\/poxvirus\/mpox\/response\/2022\/index.html"},{"key":"10767_CR19","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.virs.2022.07.006","volume":"37","author":"Q Gong","year":"2022","unstructured":"Gong Q, Wang C, Chuai X, Chiu S (2022) Monkeypox virus: a re-emergent threat to humans. Virol Sin 37:477\u2013482. https:\/\/doi.org\/10.1016\/j.virs.2022.07.006","journal-title":"Virol Sin"},{"key":"10767_CR20","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1080\/22221751.2022.2132882","volume":"11","author":"MmM Hatmal","year":"2022","unstructured":"Hatmal MmM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, Albakri KA, Abedalbaset Alzyoud A, Kadir R, Mohamud R (2022) Comprehensive literature review of monkeypox. Emerg Microbes Infect 11:2600\u20132631. https:\/\/doi.org\/10.1080\/22221751.2022.2132882","journal-title":"Emerg Microbes Infect"},{"key":"10767_CR21","unstructured":"WHO (2022) Multi-country outbreak of monkeypox. World Health Organization https:\/\/www.who.int\/publications\/m\/item\/multi-country-outbreak-of-monkeypox--external-situation-report--10---16-november-2022."},{"key":"10767_CR22","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1086\/505880","volume":"194","author":"MG Reynolds","year":"2006","unstructured":"Reynolds MG, Yorita KL, Kuehnert MJ, Davidson WB, Huhn GD, Holman RC, Damon IK (2006) Clinical manifestations of human Monkeypox influenced by route of infection. J Infect Dis 194:773\u2013780. https:\/\/doi.org\/10.1086\/505880","journal-title":"J Infect Dis"},{"key":"10767_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1088471","author":"S Khattak","year":"2023","unstructured":"Khattak S, Rauf MA, Ali Y, Yousaf MT, Liu Z, Wu D-D, Ji X-Y (2023) The monkeypox diagnosis, treatments and prevention: a review. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2022.1088471","journal-title":"Front Cell Infect Microbiol"},{"key":"10767_CR24","first-page":"7320","volume":"20","author":"AK Yadav","year":"2022","unstructured":"Yadav AK, Srivastava A, Verma P, Srivastava P, Gupta D, Nooreen Z (2022) A comprehensive review on Monkeypox virus transmission, pathogenesis, treatments and its preventive measures. NeuroQuantology 20:7320\u20137335","journal-title":"NeuroQuantology"},{"key":"10767_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109382","author":"S Upadhayay","year":"2022","unstructured":"Upadhayay S, Arthur R, Soni D, Yadav P, Navik U, Singh R, Gurjeet Singh T, Kumar P (2022) Monkeypox infection: the past, present, and future. Int Immunopharmacol. https:\/\/doi.org\/10.1016\/j.intimp.2022.109382","journal-title":"Int Immunopharmacol"},{"key":"10767_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105794","author":"AAA Aljabali","year":"2022","unstructured":"Aljabali AAA, Obeid MA, Nusair MB, Hmedat A, Tambuwala MM (2022) Monkeypox virus: an emerging epidemic. Microb Pathog. https:\/\/doi.org\/10.1016\/j.micpath.2022.105794","journal-title":"Microb Pathog"},{"key":"10767_CR27","unstructured":"CDC (2023) Interim clinical guidance for the treatment of Mpox. Centers for Disease Control and Prevention https:\/\/www.cdc.gov\/poxvirus\/mpox\/clinicians\/treatment.html#print"},{"key":"10767_CR28","unstructured":"ClinicalTrials.gov Monkeypox. https:\/\/clinicaltrials.gov\/search?cond=Monkeypox&page=4"},{"key":"10767_CR29","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1016\/j.vaccine.2023.04.010","volume":"41","author":"RL Roper","year":"2023","unstructured":"Roper RL, Garzino-Demo A, Del Rio C, Br\u00e9chot C, Gallo R, Hall W, Esparza J, Reitz M, Schinazi RF, Parrington M, Tartaglia J, Koopmans M, Osorio J, Nitsche A, Huan TB, LeDuc J, Gessain A, Weaver S, Mahalingam S et al (2023) Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies. Vaccine 41:3171\u20133177. https:\/\/doi.org\/10.1016\/j.vaccine.2023.04.010","journal-title":"Vaccine"},{"key":"10767_CR30","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s40265-022-01742-y","volume":"82","author":"JG Rizk","year":"2022","unstructured":"Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y (2022) Prevention and treatment of monkeypox. Drugs 82:957\u2013963. https:\/\/doi.org\/10.1007\/s40265-022-01742-y","journal-title":"Drugs"},{"key":"10767_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2022.10.002","volume":"68","author":"H Li","year":"2022","unstructured":"Li H, Zhang H, Ding K, Wang X-H, Sun G-Y, Liu Z-X, Luo Y (2022) The evolving epidemiology of monkeypox virus. Cytokine Growth Factor Rev 68:1\u201312. https:\/\/doi.org\/10.1016\/j.cytogfr.2022.10.002","journal-title":"Cytokine Growth Factor Rev"},{"key":"10767_CR32","unstructured":"USFDA (2021) TPOXX (tecovirimat) Label. U.S Food and Drug Administration https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/214460s000,214461s000lbl.pdf"},{"key":"10767_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28229","author":"E Khani","year":"2023","unstructured":"Khani E, Afsharirad B, Entezari-Maleki T (2023) Monkeypox treatment: current evidence and future perspectives. J Med Virol. https:\/\/doi.org\/10.1002\/jmv.28229","journal-title":"J Med Virol"},{"key":"10767_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4314\/ajcem.v24i1.1","volume":"24","author":"TO Musa-Booth","year":"2023","unstructured":"Musa-Booth TO, Medugu N, Adegboro B, Babazhitsu M (2023) A review of the epidemiology, diagnosis, treatment, vaccines and economic impact of human monkeypox (Mpox) outbreaks. Afr J Clin Exper Microbiol 24:1\u20138. https:\/\/doi.org\/10.4314\/ajcem.v24i1.1","journal-title":"Afr J Clin Exper Microbiol"},{"key":"10767_CR35","doi-asserted-by":"publisher","first-page":"6246","DOI":"10.1128\/aac.00977-13","volume":"57","author":"M Mucker Eric","year":"2013","unstructured":"Mucker Eric M, Goff Arthur J, Shamblin Joshua D, Grosenbach Douglas W, Damon Inger K, Mehal Jason M, Holman Robert C, Carroll D, Gallardo N, Olson Victoria A, Clemmons Cody J, Hudson P, Hruby Dennis E (2013) Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (smallpox). Antimicrob Agents Chemother 57:6246\u20136253. https:\/\/doi.org\/10.1128\/aac.00977-13","journal-title":"Antimicrob Agents Chemother"},{"key":"10767_CR36","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1177\/135965350701200802","volume":"12","author":"S Duraffour","year":"2007","unstructured":"Duraffour S, Snoeck R, De Vos R, Van Den Oord JJ, Crance J-M, Garin D, Hruby DE, Jordan R, De Clercq E, Andrei G (2007) Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Antivir Ther 12:1205\u20131216. https:\/\/doi.org\/10.1177\/135965350701200802","journal-title":"Antivir Ther"},{"key":"10767_CR37","doi-asserted-by":"publisher","first-page":"13139","DOI":"10.1128\/jvi.79.20.13139-13149.2005","volume":"79","author":"G Yang","year":"2005","unstructured":"Yang G, Pevear Daniel C, Davies Marc H, Collett Marc S, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins John W, Baker Robert O, Buller RLM, Touchette E, Waller K, Schriewer J, Neyts J, DeClercq E, Jones K et al (2005) An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge. J Virol 79:13139\u201313149. https:\/\/doi.org\/10.1128\/jvi.79.20.13139-13149.2005","journal-title":"J Virol"},{"key":"10767_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.antiviral.2008.03.005","volume":"79","author":"A Nalca","year":"2008","unstructured":"Nalca A, Hatkin JM, Garza NL, Nichols DK, Norris SW, Hruby DE, Jordan R (2008) Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model. Antiviral Res 79:121\u2013127. https:\/\/doi.org\/10.1016\/j.antiviral.2008.03.005","journal-title":"Antiviral Res"},{"key":"10767_CR39","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1093\/infdis\/jiy326","volume":"218","author":"AT Russo","year":"2018","unstructured":"Russo AT, Grosenbach DW, Brasel TL, Baker RO, Cawthon AG, Reynolds E, Bailey T, Kuehl PJ, Sugita V, Agans K, Hruby DE (2018) Effects of treatment delay on efficacy of tecovirimat following lethal aerosol monkeypox virus challenge in cynomolgus macaques. J Infect Dis 218:1490\u20131499. https:\/\/doi.org\/10.1093\/infdis\/jiy326","journal-title":"J Infect Dis"},{"key":"10767_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2023.106960","author":"J Nyame","year":"2023","unstructured":"Nyame J, Punniyakotti S, Khera K, Pal RS, Varadarajan N, Sharma P (2023) Challenges in the treatment and prevention of Monkeypox infection; a comprehensive review. Acta Trop. https:\/\/doi.org\/10.1016\/j.actatropica.2023.106960","journal-title":"Acta Trop"},{"key":"10767_CR41","doi-asserted-by":"publisher","first-page":"4468","DOI":"10.1021\/acs.jmedchem.3c00069","volume":"66","author":"J Wang","year":"2023","unstructured":"Wang J, Shahed-Ai-Mahmud M, Chen A, Li K, Tan H, Joyce R (2023) an overview of antivirals against Monkeypox virus and other orthopoxviruses. J Med Chem 66:4468\u20134490. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c00069","journal-title":"J Med Chem"},{"key":"10767_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7110369","author":"B Ortiz-Saavedra","year":"2022","unstructured":"Ortiz-Saavedra B, Le\u00f3n-Figueroa DA, Montes-Madariaga ES, Ricardo-Mart\u00ednez A, Alva N, Cabanillas-Ramirez C, Barboza JJ, Siddiq A, Coaguila Cusicanqui LA, Bonilla-Aldana DK, Rodriguez-Morales AJ (2022) Antiviral treatment against Monkeypox: a scoping review. Trop Med Infect Dis. https:\/\/doi.org\/10.3390\/tropicalmed7110369","journal-title":"Trop Med Infect Dis"},{"key":"10767_CR43","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ijid.2022.11.040","volume":"127","author":"MA Shamim","year":"2023","unstructured":"Shamim MA, Padhi BK, Satapathy P, Veeramachaneni SD, Chatterjee C, Tripathy S, Akhtar N, Pradhan A, Dwivedi P, Mohanty A, Rodriguez-Morales AJ, Sah R, Al-Tammemi AaB, Al-Tawfiq JA, Nowrouzi-Kia B, Chattu VK (2023) The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review. Int J Infect Dis 127:150\u2013161. https:\/\/doi.org\/10.1016\/j.ijid.2022.11.040","journal-title":"Int J Infect Dis"},{"key":"10767_CR44","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/S1473-3099(22)00228-6","volume":"22","author":"H Adler","year":"2022","unstructured":"Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MBJ, Duncan CJA, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L et al (2022) Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis 22:1153\u20131162. https:\/\/doi.org\/10.1016\/S1473-3099(22)00228-6","journal-title":"Lancet Infect Dis"},{"key":"10767_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/v3010047","volume":"3","author":"AD Rice","year":"2011","unstructured":"Rice AD, Adams MM, Wallace G, Burrage AM, Lindsey SF, Smith AJ, Swetnam D, Manning BR, Gray SA, Lampert B, Foster S, Lanier R, Robertson A, Painter G, Moyer RW (2011) Efficacy of CMX001 as a post exposure antiviral in New Zealand white rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans. Viruses 3:47\u201362. https:\/\/doi.org\/10.3390\/v3010047","journal-title":"Viruses"},{"key":"10767_CR46","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00927-20","author":"L Hutson Christina","year":"2021","unstructured":"Hutson Christina L, Kondas Ashley V, Mauldin Mathew R, Doty Jeffrey B, Grossi Irma M, Morgan Clint N, Ostergaard Sharon D, Hughes Christine M, Nakazawa Y, Kling C, Martin Brock E, Ellison James A, Carroll Darin D, Gallardo-Romero Nadia F, Olson Victoria A (2021) Pharmacokinetics and efficacy of a potential smallpox therapeutic, brincidofovir, in a lethal monkeypox virus animal model. mSphere. https:\/\/doi.org\/10.1128\/msphere.00927-20","journal-title":"mSphere"},{"key":"10767_CR47","doi-asserted-by":"publisher","DOI":"10.1017\/cts.2023.11","author":"M Ghaseminia","year":"2023","unstructured":"Ghaseminia M (2023) Preventing monkeypox outbreaks: focus on diagnosis, care, treatment, and vaccination. J Clin Transl Sci. https:\/\/doi.org\/10.1017\/cts.2023.11","journal-title":"J Clin Transl Sci"},{"key":"10767_CR48","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0140-6736(22)02075-X","volume":"401","author":"O Mitj\u00e0","year":"2023","unstructured":"Mitj\u00e0 O, Ogoina D, Titanji BK, Galvan C, Muyembe J-J, Marks M, Orkin CM (2023) Monkeypox. The Lancet 401:60\u201374. https:\/\/doi.org\/10.1016\/S0140-6736(22)02075-X","journal-title":"The Lancet"},{"key":"10767_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/life13010249","author":"M Patel","year":"2023","unstructured":"Patel M, Adnan M, Aldarhami A, Bazaid AS, Saeedi NH, Alkayyal AA, Saleh FM, Awadh IB, Saeed A, Alshaghdali K (2023) Current insights into diagnosis, prevention strategies, treatment, therapeutic targets, and challenges of monkeypox (Mpox) infections in human populations. Life. https:\/\/doi.org\/10.3390\/life13010249","journal-title":"Life"},{"key":"10767_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27902","author":"SK Saxena","year":"2023","unstructured":"Saxena SK, Ansari S, Maurya VK, Kumar S, Jain A, Paweska JT, Tripathi AK, Abdel-Moneim AS (2023) Re-emerging human monkeypox: a major public-health debacle. J Med Viro. https:\/\/doi.org\/10.1002\/jmv.27902","journal-title":"J Med Viro"},{"key":"10767_CR51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0166-3542(02)00196-1","volume":"57","author":"RO Baker","year":"2003","unstructured":"Baker RO, Bray M, Huggins JW (2003) Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res 57:13\u201323. https:\/\/doi.org\/10.1016\/S0166-3542(02)00196-1","journal-title":"Antiviral Res"},{"key":"10767_CR52","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nature04295","volume":"439","author":"KJ Stittelaar","year":"2006","unstructured":"Stittelaar KJ, Neyts J, Naesens L, van Amerongen G, van Lavieren RF, Hol\u00fd A, De Clercq E, Niesters HGM, Fries E, Maas C, Mulder PGH, van der Zeijst BAM, Osterhaus ADME (2006) Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature 439:745\u2013748. https:\/\/doi.org\/10.1038\/nature04295","journal-title":"Nature"},{"key":"10767_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1132250","author":"L Niu","year":"2023","unstructured":"Niu L, Liang D, Ling Q, Zhang J, Li Z, Zhang D, Xia P, Zhu Z, Lin J, Shi A, Ma J, Yu P, Liu X (2023) Insights into monkeypox pathophysiology, global prevalence, clinical manifestation and treatments. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2023.1132250","journal-title":"Front Immunol"},{"key":"10767_CR54","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28218","author":"AR Raccagni","year":"2023","unstructured":"Raccagni AR, Candela C, Bruzzesi E, Mileto D, Canetti D, Rizzo A, Castagna A, Nozza S (2023) Real-life use of cidofovir for the treatment of severe monkeypox cases. J Med Virol. https:\/\/doi.org\/10.1002\/jmv.28218","journal-title":"J Med Virol"},{"key":"10767_CR55","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1099\/jgv.0.000422","volume":"97","author":"OY Mazurkov","year":"2016","unstructured":"Mazurkov OY, Kabanov AS, Shishkina LN, Sergeev AA, Skarnovich MO, Bormotov NI, Skarnovich MA, Ovchinnikova AS, Titova KA, Galahova DO (2016) New effective chemically synthesized anti-smallpox compound NIOCH-14. J Gen Virol 97:1229\u20131239. https:\/\/doi.org\/10.1099\/jgv.0.000422","journal-title":"J Gen Virol"},{"key":"10767_CR56","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01683-19","author":"D Delaune","year":"2020","unstructured":"Delaune D, Iseni F (2020) Drug development against smallpox: present and future. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/aac.01683-19","journal-title":"Antimicrob Agents Chemother"},{"key":"10767_CR57","unstructured":"WHO (2021) WHO advisory committee on variola virus research: report of the twenty-third meeting, virtual meeting, 3\u20134 November 2021. World Health Organization https:\/\/www.who.int\/publications\/i\/item\/9789240046740"},{"key":"10767_CR58","unstructured":"WHO (2022) Vaccines and immunization for monkeypox: interim guidance. World Health Organization https:\/\/www.who.int\/publications\/i\/item\/WHO-MPX-Immunization"},{"key":"10767_CR59","doi-asserted-by":"publisher","first-page":"194","DOI":"10.55544\/jrasb.1.4.28","volume":"1","author":"SS Patil","year":"2022","unstructured":"Patil SS (2022) Monkey pox pathogenesis, diagnosis, treatment: a comprehensive review. J Res Appl Sci Biotechnol 1:194\u2013200. https:\/\/doi.org\/10.55544\/jrasb.1.4.28","journal-title":"J Res Appl Sci Biotechnol"},{"key":"10767_CR60","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.medcle.2023.01.005","volume":"160","author":"J Reina","year":"2023","unstructured":"Reina J, Iglesias C (2023) Vaccines against monkeypox. Med Cl\u00edn (English Edition) 160:305\u2013309. https:\/\/doi.org\/10.1016\/j.medcle.2023.01.005","journal-title":"Med Cl\u00edn (English Edition)"},{"key":"10767_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28306","author":"AA Rabaan","year":"2023","unstructured":"Rabaan AA, Abas AH, Tallei TE, Al-Zaher MA, Al-Sheef NM, Fatimawali, Al-Nass EZ, Al-Ebrahim EA, Effendi Y, Idroes R, Alhabib MF, Al-Fheid HA, Adam AA, Bin Emran T (2023) Monkeypox outbreak 2022: what we know so far and its potential drug targets and management strategies. J Med Virol. https:\/\/doi.org\/10.1002\/jmv.28306","journal-title":"J Med Virol"},{"key":"10767_CR62","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1056\/NEJMra2208860","volume":"387","author":"A Gessain","year":"2022","unstructured":"Gessain A, Nakoune E, Yazdanpanah Y (2022) Monkeypox. N Engl J Med 387:1783\u20131793. https:\/\/doi.org\/10.1056\/NEJMra2208860","journal-title":"N Engl J Med"},{"key":"10767_CR63","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1080\/22221751.2022.2095309","volume":"11","author":"Y Xiang","year":"2022","unstructured":"Xiang Y, White A (2022) Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters. Emerg Microbes Infect 11:1768\u20131777. https:\/\/doi.org\/10.1080\/22221751.2022.2095309","journal-title":"Emerg Microbes Infect"},{"key":"10767_CR64","doi-asserted-by":"publisher","first-page":"7805","DOI":"10.1128\/jvi.03481-12","volume":"87","author":"J Hatch Graham","year":"2013","unstructured":"Hatch Graham J, Graham Victoria A, Bewley Kevin R, Tree Julia A, Dennis M, Taylor I, Funnell Simon GP, Bate Simon R, Steeds K, Tipton T, Bean T, Hudson L, Atkinson Deborah J, McLuckie G, Charlwood M, Roberts Allen DG, Vipond J (2013) Assessment of the protective effect of imvamune and Acam 2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques. J Virol 87:7805\u20137815. https:\/\/doi.org\/10.1128\/jvi.03481-12","journal-title":"J Virol"},{"key":"10767_CR65","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2147\/DDDT.S3687","volume":"4","author":"A Nalca","year":"2010","unstructured":"Nalca A, Zumbrun EE (2010) ACAM2000\u2122: the new smallpox vaccine for United States Strategic National Stockpile. Drug Des Devel Ther 4:71\u201379. https:\/\/doi.org\/10.2147\/DDDT.S3687","journal-title":"Drug Des Devel Ther"},{"key":"10767_CR66","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1128\/aac.00208-15","volume":"59","author":"A Berhanu","year":"2015","unstructured":"Berhanu A, Prigge Jonathan T, Silvera Peter M, Honeychurch Kady M, Hruby Dennis E, Grosenbach Douglas W (2015) Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection. Antimicrob Agents Chemother 59:4296\u20134300. https:\/\/doi.org\/10.1128\/aac.00208-15","journal-title":"Antimicrob Agents Chemother"},{"key":"10767_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/v14112496","author":"N Sudarmaji","year":"2022","unstructured":"Sudarmaji N, Kifli N, Hermansyah A, Yeoh SF, Goh B-H, Ming LC (2022) Prevention and treatment of monkeypox: a systematic review of preclinical studies. Viruses. https:\/\/doi.org\/10.3390\/v14112496","journal-title":"Viruses"},{"key":"10767_CR68","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1093\/infdis\/jis753","volume":"207","author":"RN Greenberg","year":"2013","unstructured":"Greenberg RN, Overton ET, Haas DW, Frank I, Goldman M, von Krempelhuber A, Virgin G, B\u00e4deker N, Vollmar J, Chaplin P (2013) Safety, immunogenicity, and surrogate markers of clinical efficacy for modified vaccinia ankara as a smallpox vaccine in HIV-infected subjects. J Infect Dis 207:749\u2013758. https:\/\/doi.org\/10.1093\/infdis\/jis753","journal-title":"J Infect Dis"},{"key":"10767_CR69","doi-asserted-by":"publisher","first-page":"734","DOI":"10.15585\/mmwr.mm7122e1","volume":"71","author":"AK Rao","year":"2022","unstructured":"Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, Campos-Outcalt D, Morgan RL, Damon I, S\u00e1nchez PJ (2022) Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2022. Morb Mortal Wkly Rep 71:734\u2013742. https:\/\/doi.org\/10.15585\/mmwr.mm7122e1","journal-title":"Morb Mortal Wkly Rep"},{"key":"10767_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030396","author":"MS Keckler","year":"2020","unstructured":"Keckler MS, Salzer JS, Patel N, Townsend MB, Nakazawa YJ, Doty JB, Gallardo-Romero NF, Satheshkumar PS, Carroll DS, Karem KL, Damon IK (2020) IMVAMUNE\u00ae and ACAM2000\u00ae provide different protection against disease when administered postexposure in an intranasal monkeypox challenge prairie dog model. Vaccines. https:\/\/doi.org\/10.3390\/vaccines8030396","journal-title":"Vaccines"},{"key":"10767_CR71","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s10989-023-10535-0","volume":"29","author":"MMAK Shawan","year":"2023","unstructured":"Shawan MMAK, Sharma AR, Halder SK, Arian TA, Shuvo MN, Sarker SR, Hasan MA (2023) Advances in computational and bioinformatics tools and databases for designing and developing a multi-epitope-based peptide vaccine. Int J Pept Res Ther 29:60. https:\/\/doi.org\/10.1007\/s10989-023-10535-0","journal-title":"Int J Pept Res Ther"},{"key":"10767_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.985450","author":"S Aiman","year":"2022","unstructured":"Aiman S, Alhamhoom Y, Ali F, Rahman N, Rastrelli L, Khan A, Farooq QuA, Ahmed A, Khan A, Li C (2022) Multi-epitope chimeric vaccine design against emerging Monkeypox virus via reverse vaccinology techniques\u2014a bioinformatics and immunoinformatics approach. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.985450","journal-title":"Front Immunol"},{"key":"10767_CR73","doi-asserted-by":"publisher","first-page":"e0286224","DOI":"10.1371\/journal.pone.0286224","volume":"18","author":"S Sanami","year":"2023","unstructured":"Sanami S, Nazarian S, Ahmad S, Raeisi E, Tahir ul Qamar M, Tahmasebian S, Pazoki-Toroudi H, Fazeli M, Ghatreh Samani M (2023) In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus. PLoS ONE 18:e0286224. https:\/\/doi.org\/10.1371\/journal.pone.0286224","journal-title":"PLoS ONE"},{"key":"10767_CR74","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2158942","author":"S Khan","year":"2022","unstructured":"Khan S, Irfan M, Hameed AR, Ullah A, Abideen SA, Ahmad S, Haq MU, El Bakri Y, Al-Harbi AI, Ali M, Haleem A (2022) Vaccinomics to design a multi-epitope-based vaccine against monkeypox virus using surface-associated proteins. Biomol Struct Dyn. https:\/\/doi.org\/10.1080\/07391102.2022.2158942","journal-title":"Biomol Struct Dyn"},{"key":"10767_CR75","doi-asserted-by":"publisher","first-page":"7821","DOI":"10.1080\/07391102.2022.2125441","volume":"41","author":"A Ullah","year":"2022","unstructured":"Ullah A, Shahid FA, Haq MU, Tahir ul Qamar M, Irfan M, Shaker B, Ahmad S, Alrumaihi F, Allemailem KS, Almatroudi A (2022) An integrative reverse vaccinology, immunoinformatic, docking and simulation approaches towards designing of multi-epitopes based vaccine against monkeypox virus. Biomol Struct Dyn 41:7821\u20137834. https:\/\/doi.org\/10.1080\/07391102.2022.2125441","journal-title":"Biomol Struct Dyn"},{"key":"10767_CR76","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.22207\/JPAM.16.SPL1.04","volume":"16","author":"P Bansal","year":"2022","unstructured":"Bansal P, Gupta M, Sangwan S, Bhatia GK, Ramniwas S, Chandran D, Dey A, Dhama K, Tuli HS (2022) Computational purposing phytochemicals against cysteine protease of monkeypox virus: an in-silico approach. J Pure Appl Microbiol 16:3144\u20133154. https:\/\/doi.org\/10.22207\/JPAM.16.SPL1.04","journal-title":"J Pure Appl Microbiol"},{"key":"10767_CR77","doi-asserted-by":"publisher","DOI":"10.3390\/ph15091129","author":"HN Altayb","year":"2022","unstructured":"Altayb HN (2022) Fludarabine, a potential DNA-dependent RNA polymerase inhibitor, as a prospective drug against monkeypox virus: a computational approach. Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph15091129","journal-title":"Pharmaceuticals"},{"key":"10767_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1157627","author":"S Akash","year":"2023","unstructured":"Akash S, Hossain A, Hossain MS, Rahman MM, Ahmed MZ, Ali N, Valis M, Kuca K, Sharma R (2023) Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: a computational drug design approach. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2023.1157627","journal-title":"Front Cell Infect Microbiol"},{"key":"10767_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.675287","author":"BAC Rattis","year":"2021","unstructured":"Rattis BAC, Ramos SG, Celes MRN (2021) Curcumin as a potential treatment for COVID-19. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.675287","journal-title":"Front Pharmacol"},{"key":"10767_CR80","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC136.534","author":"S Akash","year":"2023","unstructured":"Akash S, Islam MR, Rahman MM, Hossain MS, Azad MAK, Sharma R (2023) Investigation of the new inhibitors by modified derivatives of pinocembrin for the treatment of monkeypox and marburg virus with different computational approaches. Biointerface Res Appl Chem. https:\/\/doi.org\/10.33263\/BRIAC136.534","journal-title":"Biointerface Res Appl Chem"},{"key":"10767_CR81","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s11224-022-02079-8","volume":"34","author":"TM Burkhanova","year":"2022","unstructured":"Burkhanova TM, Krysantieva AI, Babashkina MG, Konyaeva IA, Monina LN, Goncharenko AN, Safin DA (2022) In silico analyses of betulin: DFT studies, corrosion inhibition properties, ADMET prediction, and molecular docking with a series of SARS-CoV-2 and monkeypox proteins. Struct Chem 34:1545\u20131556. https:\/\/doi.org\/10.1007\/s11224-022-02079-8","journal-title":"Struct Chem"},{"key":"10767_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031444","author":"X Hu","year":"2023","unstructured":"Hu X, An S, Chu J, Liang B, Liao Y, Jiang J, Lin Y, Ye L, Liang H (2023) Potential inhibitors of monkeypox virus revealed by molecular modeling approach to viral DNA topoisomerase I. Molecules. https:\/\/doi.org\/10.3390\/molecules28031444","journal-title":"Molecules"},{"key":"10767_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911570","author":"T-P Lam","year":"2022","unstructured":"Lam T-P, Tran V-H, Mai TT, Lai NV, Dang B-TN, Le M-T, Tran T-D, Trinh D-TT, Thai K-M (2022) Identification of diosmin and flavin adenine dinucleotide as repurposing treatments for monkeypox virus: a computational study. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms231911570","journal-title":"Int J Mol Sci"},{"key":"10767_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165277","author":"HY Lam","year":"2022","unstructured":"Lam HY, Guan JS, Mu Y (2022) In silico repurposed drugs against monkeypox virus. Molecules. https:\/\/doi.org\/10.3390\/molecules27165277","journal-title":"Molecules"},{"key":"10767_CR85","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.antiviral.2007.06.005","volume":"76","author":"DF Smee","year":"2007","unstructured":"Smee DF, Hurst BL, Wong M-H, Glazer RI, Rahman A, Sidwell RW (2007) Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus. Antiviral Res 76:124\u2013129. https:\/\/doi.org\/10.1016\/j.antiviral.2007.06.005","journal-title":"Antiviral Res"},{"key":"10767_CR86","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-022-10550-1","author":"AK Sahoo","year":"2022","unstructured":"Sahoo AK, Augusthian PD, Muralitharan I, Vivek-Ananth RP, Kumar K, Kumar G, Ranganathan G, Samal A (2022) In silico identification of potential inhibitors of vital monkeypox virus proteins from FDA approved drugs. Mol Divers. https:\/\/doi.org\/10.1007\/s11030-022-10550-1","journal-title":"Mol Divers"},{"key":"10767_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214287","author":"G Preet","year":"2022","unstructured":"Preet G, Oluwabusola ET, Milne BF, Ebel R, Jaspars M (2022) Computational repurposing of mitoxantrone-related structures against monkeypox virus: a molecular docking and 3D pharmacophore study. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232214287","journal-title":"Int J Mol Sci"},{"key":"10767_CR88","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-023-10636-4","author":"V Srivastava","year":"2023","unstructured":"Srivastava V, Naik B, Godara P, Das D, Mattaparthi VSK, Prusty D (2023) Identification of FDA-approved drugs with triple targeting mode of action for the treatment of monkeypox: a high throughput virtual screening study. Mol Divers. https:\/\/doi.org\/10.1007\/s11030-023-10636-4","journal-title":"Mol Divers"},{"key":"10767_CR89","doi-asserted-by":"publisher","first-page":"106971","DOI":"10.1016\/j.compbiomed.2023.106971","volume":"161","author":"A Sahu","year":"2023","unstructured":"Sahu A, Gaur M, Mahanandia NC, Subudhi E, Swain RP, Subudhi BB (2023) Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs against them: an in silico approach. Comput Biol Med 161:106971. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.106971","journal-title":"Comput Biol Med"},{"key":"10767_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10010011","author":"M Naveed","year":"2023","unstructured":"Naveed M, Shabbir MA, Ain N-u, Javed K, Mahmood S, Aziz T, Khan AA, Nabi G, Shahzad M, Alharbi ME, Alharbi M, Alshammari A (2023) Chain-engineering-based de novo drug design against MPXVgp169 virulent protein of monkeypox virus: a molecular modification approach. Bioengineering. https:\/\/doi.org\/10.3390\/bioengineering10010011","journal-title":"Bioengineering"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-023-10767-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-023-10767-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-023-10767-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T14:26:12Z","timestamp":1733149572000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-023-10767-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10767"],"URL":"https:\/\/doi.org\/10.1007\/s11030-023-10767-8","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,11]]},"assertion":[{"value":"24 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}