{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:00:46Z","timestamp":1771210846270,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82273793"],"award-info":[{"award-number":["No. 82273793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"the China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["No. 2019M661132"],"award-info":[{"award-number":["No. 2019M661132"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the foundation of Liaoning Provincial Department of Education","award":["No. LJKQZ20222351"],"award-info":[{"award-number":["No. LJKQZ20222351"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11030-024-11054-w","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:21:43Z","timestamp":1737609703000},"page":"4539-4553","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of selective ROCK2 inhibitors with free radical scavenging ability for the treatment of gouty arthritis"],"prefix":"10.1007","volume":"29","author":[{"given":"Ruolin","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuqiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"issue":"9","key":"11054_CR1","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.3390\/jcm10091880","volume":"10","author":"P Galozzi","year":"2021","unstructured":"Galozzi P, Bindoli S, Doria A, Oliviero F, Sfriso P (2021) Autoinflammatory features in Gouty Arthritis. J Clin Med 10(9):1880. https:\/\/doi.org\/10.3390\/jcm10091880","journal-title":"J Clin Med"},{"issue":"7","key":"11054_CR2","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1136\/annrheumdis-2017-212288","volume":"77","author":"N Dalbeth","year":"2018","unstructured":"Dalbeth N, Phipps-Green A, Frampton C, Neogi T, Taylor WJ, Merriman TR (2018) Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis. Ann Rheum Dis 77(7):1048\u20131052. https:\/\/doi.org\/10.1136\/annrheumdis-2017-212288","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"11054_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s11926-013-0392-5","volume":"16","author":"S Steiger","year":"2013","unstructured":"Steiger S, Harper JL (2013) Mechanisms of spontaneous resolution of Acute Gouty inflammation. Curr Rheumatol Rep 16(1):392. https:\/\/doi.org\/10.1007\/s11926-013-0392-5","journal-title":"Curr Rheumatol Rep"},{"key":"11054_CR4","doi-asserted-by":"publisher","first-page":"1137822","DOI":"10.3389\/fimmu.2023.1137822","volume":"14","author":"Y-r Liu","year":"2023","unstructured":"Liu Y-r, Wang J-q, Li J (2023) Role of NLRP3 in the pathogenesis and treatment of gout arthritis. Front Immunol 14:1137822. https:\/\/doi.org\/10.3389\/fimmu.2023.1137822","journal-title":"Front Immunol"},{"issue":"10","key":"11054_CR5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.3390\/cells12101367","volume":"12","author":"EJ Glotfelty","year":"2023","unstructured":"Glotfelty EJ, Tovar-y-Romo LB, Hsueh S-C, Tweedie D, Li Y, Harvey BK et al (2023) The RhoA-ROCK1\/ROCK2 pathway exacerbates inflammatory signaling in immortalized and primary microglia. Cells 12(10):1367. https:\/\/doi.org\/10.3390\/cells12101367","journal-title":"Cells"},{"issue":"1","key":"11054_CR6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/med.21980","volume":"44","author":"X Xu","year":"2023","unstructured":"Xu X, Yao L (2023) Recent advances in the development of rho kinase inhibitors (2015\u20132021). Med Res Rev 44(1):406\u2013421. https:\/\/doi.org\/10.1002\/med.21980","journal-title":"Med Res Rev"},{"issue":"4","key":"11054_CR7","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1139\/cjpp-2020-0305","volume":"99","author":"RN Tiftik","year":"2021","unstructured":"Tiftik RN, Temiz-Re\u015fito\u011flu M, G\u00fcden DS, Bayrak G, \u00dcn \u0130, Y\u0131lmaz \u015eN et al (2021) Involvement of Rho-kinase\/I\u03baB-\u03b1\/NF-\u03baB activation in IL-1\u03b2-induced inflammatory response and oxidative stress in human chondrocytes. Can J Physiol Pharmacol 99(4):418\u2013426. https:\/\/doi.org\/10.1139\/cjpp-2020-0305","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"11054_CR8","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/s42003-023-05552-0","volume":"6","author":"A Zanin-Zhorov","year":"2023","unstructured":"Zanin-Zhorov A, Chen W, Moretti J, Nyuydzefe MS, Zhorov I, Munshi R et al (2023) Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism. Commun Biol 6(1):1176. https:\/\/doi.org\/10.1038\/s42003-023-05552-0","journal-title":"Commun Biol"},{"issue":"11","key":"11054_CR9","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1002\/art.23986","volume":"58","author":"Y He","year":"2008","unstructured":"He Y, Xu H, Liang L, Zhan Z, Yang X, Yu X et al (2008) Antiinflammatory effect of rho kinase blockade via inhibition of NF-\u03baB activation in rheumatoid arthritis. Arthritis Rheum 58(11):3366\u20133376. https:\/\/doi.org\/10.1002\/art.23986","journal-title":"Arthritis Rheum"},{"issue":"1","key":"11054_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/art.25063","volume":"62","author":"H Okamoto","year":"2009","unstructured":"Okamoto H, Yoshio T, Kaneko H, Yamanaka H (2009) Inhibition of NF-\u03baB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis. Arthritis Rheum 62(1):82\u201392. https:\/\/doi.org\/10.1002\/art.25063","journal-title":"Arthritis Rheum"},{"issue":"1","key":"11054_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12886-020-01400-5","volume":"20","author":"Z Gao","year":"2020","unstructured":"Gao Z, Li Q, Zhang Y, Gao X, Li H, Yuan Z (2020) Ripasudil alleviated the inflammation of RPE cells by targeting the miR-136-5p\/ROCK\/NLRP3 pathway. BMC Ophthalmol 20(1):134. https:\/\/doi.org\/10.1186\/s12886-020-01400-5","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"11054_CR12","doi-asserted-by":"publisher","first-page":"7432797","DOI":"10.1155\/2016\/7432797","volume":"2016","author":"T Hussain","year":"2016","unstructured":"Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB, Rahu N (2016) Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev 2016(1):7432797","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"11054_CR13","doi-asserted-by":"publisher","first-page":"1652244","DOI":"10.1155\/2022\/1652244","volume":"2022","author":"T Luo","year":"2022","unstructured":"Luo T, Zhou X, Qin M, Lin Y, Lin J, Chen G et al (2022) Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS\/TXNIP\/NLRP3 pathway to prevent inflammation. Oxid Med Cell Longev 2022(1):1652244","journal-title":"Oxid Med Cell Longev"},{"key":"11054_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1652244","volume":"2022","author":"T Luo","year":"2022","unstructured":"Luo T, Zhou X, Qin M, Lin Y, Lin J, Chen G et al (2022) Corilagin restrains NLRP3 inflammasome activation and Pyroptosis through the ROS\/TXNIP\/NLRP3 pathway to prevent inflammation. Oxidative Med Cell Longev 2022:1\u201326. https:\/\/doi.org\/10.1155\/2022\/1652244","journal-title":"Oxidative Med Cell Longev"},{"issue":"1","key":"11054_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/bab.1700","volume":"66","author":"T Sho","year":"2018","unstructured":"Sho T, Xu J (2018) Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation. Biotechnol Appl Chem 66(1):4\u201313. https:\/\/doi.org\/10.1002\/bab.1700","journal-title":"Biotechnol Appl Chem"},{"issue":"2","key":"11054_CR16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/antiox11020195","volume":"11","author":"SJ Cha","year":"2022","unstructured":"Cha SJ, Kim K (2022) Effects of the Edaravone, a drug approved for the treatment of amyotrophic lateral sclerosis, on mitochondrial function and Neuroprotection. Antioxidants 11(2):195. https:\/\/doi.org\/10.3390\/antiox11020195","journal-title":"Antioxidants"},{"key":"11054_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6908884","volume":"2022","author":"Y Zeng","year":"2022","unstructured":"Zeng Y, Zhu G, Zhu M, Song J, Cai H, Song Y et al (2022) Edaravone attenuated particulate matter-induced lung inflammation by inhibiting ROS-NF-\u03baB signaling pathway. Oxid Med Cell Longev 2022:1\u201311. https:\/\/doi.org\/10.1155\/2022\/6908884","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"11054_CR18","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1021\/acs.jmedchem.5b00683","volume":"59","author":"Y Feng","year":"2016","unstructured":"Feng Y, LoGrasso PV, Defert O, Li R (2016) Rho Kinase (ROCK) inhibitors and their therapeutic potential. J Med Chem 59(6):2269\u20132300. https:\/\/doi.org\/10.1021\/acs.jmedchem.5b00683","journal-title":"J Med Chem"},{"issue":"12","key":"11054_CR19","doi-asserted-by":"publisher","first-page":"108336","DOI":"10.1016\/j.cclet.2023.108336","volume":"34","author":"Y You","year":"2023","unstructured":"You Y, Zhu K, Wang J, Liang Q, Li W, Wang L et al (2023) ROCK inhibitor: focus on recent updates. Chin Chem Lett 34(12):108336. https:\/\/doi.org\/10.1016\/j.cclet.2023.108336","journal-title":"Chin Chem Lett"},{"issue":"24","key":"11054_CR20","doi-asserted-by":"publisher","first-page":"11074","DOI":"10.1021\/acs.jmedchem.8b01098","volume":"61","author":"AD Hobson","year":"2018","unstructured":"Hobson AD, Judge RA, Aguirre AL, Brown BS, Cui Y, Ding P et al (2018) Identification of selective dual ROCK1 and ROCK2 inhibitors using structure-based drug design. J Med Chem 61(24):11074\u201311100. https:\/\/doi.org\/10.1021\/acs.jmedchem.8b01098","journal-title":"J Med Chem"},{"key":"11054_CR21","doi-asserted-by":"publisher","first-page":"700956","DOI":"10.3389\/fchem.2021.700956","volume":"9","author":"Y Wang","year":"2021","unstructured":"Wang Y, He M, Li X, Chai J, Jiang Q, Peng C et al (2021) Design, synthesis, and biological evaluation of Pyrano[2,3-c]-pyrazole\u2013based RalA inhibitors against hepatocellular carcinoma. Front Chem 9:700956. https:\/\/doi.org\/10.3389\/fchem.2021.700956","journal-title":"Front Chem"},{"issue":"10","key":"11054_CR22","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1016\/j.bmcl.2016.03.024","volume":"26","author":"N Polkam","year":"2016","unstructured":"Polkam N, Ramaswamy VR, Rayam P, Allaka TR, Anantaraju HS, Dharmarajan S et al (2016) Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives. Bioorg Med Chem Lett 26(10):2562\u20132568. https:\/\/doi.org\/10.1016\/j.bmcl.2016.03.024","journal-title":"Bioorg Med Chem Lett"},{"issue":"18","key":"11054_CR23","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1039\/c9qo00484j","volume":"6","author":"Y Peng","year":"2019","unstructured":"Peng Y, He Q, Zhang X, Yang C (2019) Pd-Catalyzed intramolecular C\u2013H activation and C\u2013S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant. Org Chem Front 6(18):3234\u20133237. https:\/\/doi.org\/10.1039\/c9qo00484j","journal-title":"Org Chem Front"},{"key":"11054_CR24","doi-asserted-by":"publisher","first-page":"128765","DOI":"10.1016\/j.foodchem.2020.128765","volume":"345","author":"Y-Y Wang","year":"2021","unstructured":"Wang Y-Y, Wang C-Y, Wang S-T, Li Y-Q, Mo H-Z, He J-X (2021) Physicochemical properties and antioxidant activities of tree peony (Paeonia suffruticosa Andr.) seed protein hydrolysates obtained with different proteases. Food Chem 345:128765. https:\/\/doi.org\/10.1016\/j.foodchem.2020.128765","journal-title":"Food Chem"},{"key":"11054_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090964","author":"I Galv\u00e3o","year":"2019","unstructured":"Galv\u00e3o I, Athayde RM, Perez DA, Reis AC, Rezende L, de Oliveira VLS, Rezende BM, Gon\u00e7alves WA, Sousa LP, Teixeira MM et al (2019) ROCK Inhibition drives resolution of acute inflammation by enhancing neutrophil Apoptosis. Cells. https:\/\/doi.org\/10.3390\/cells8090964","journal-title":"Cells"},{"issue":"7","key":"11054_CR26","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1021\/acs.jmedchem.0c01940","volume":"64","author":"F He","year":"2021","unstructured":"He F, Chou CJ, Scheiner M, Poeta E, Yuan Chen N, Gunesch S et al (2021) Melatonin- and Ferulic Acid-based HDAC6 selective inhibitors exhibit Pronounced Immunomodulatory effects in Vitro and Neuroprotective effects in a pharmacological Alzheimer\u2019s Disease Mouse Model. J Med Chem 64(7):3794\u20133812. https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01940","journal-title":"J Med Chem"},{"issue":"6","key":"11054_CR27","doi-asserted-by":"publisher","first-page":"713","DOI":"10.2174\/1871520615666151009114759","volume":"16","author":"BM Mistry","year":"2016","unstructured":"Mistry BM, Patel RV, Keum YS, Kim DH (2016) Synthesis of 9-O-3-(1-piperazinyl\/morpholinyl\/piperidinyl)pentyl-berberines as potential antioxidant and cytotoxic agents. Anticancer Agents Med Chem 16(6):713\u2013721. https:\/\/doi.org\/10.2174\/1871520615666151009114759","journal-title":"Anticancer Agents Med Chem"},{"issue":"5","key":"11054_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/13510002.1996.11747069","volume":"2","author":"Y Yamamoto","year":"1996","unstructured":"Yamamoto Y, Kuwahara T, Watanabe K, Watanabe K (1996) Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one. Redox Rep 2(5):333\u2013338. https:\/\/doi.org\/10.1080\/13510002.1996.11747069","journal-title":"Redox Rep"},{"key":"11054_CR29","doi-asserted-by":"publisher","first-page":"1078701","DOI":"10.3389\/fnut.2023.1078701","volume":"10","author":"M Mestanza","year":"2023","unstructured":"Mestanza M, Mori-Culqui PL, Chavez SG (2023) Changes of polyphenols and antioxidants of Arabica coffee varieties during roasting. Front Nutr 10:1078701. https:\/\/doi.org\/10.3389\/fnut.2023.1078701","journal-title":"Front Nutr"},{"issue":"3","key":"11054_CR30","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.apsb.2021.09.018","volume":"12","author":"F Du","year":"2022","unstructured":"Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y et al (2022) Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharm Sin B 12(3):1377\u20131389. https:\/\/doi.org\/10.1016\/j.apsb.2021.09.018","journal-title":"Acta Pharm Sin B"},{"key":"11054_CR31","doi-asserted-by":"publisher","first-page":"107064","DOI":"10.1016\/j.bioorg.2023.107064","volume":"143","author":"R Cao","year":"2024","unstructured":"Cao R, Du F, Cui Y, Qi M, Zhuang J, Wang J et al (2024) Synthesis and biological evaluations of 8-biaryl-2,2-dimethylbenzopyranamide derivatives against Alzheimer\u2019s disease and ischemic stroke. Bioorg Chem 143:107064. https:\/\/doi.org\/10.1016\/j.bioorg.2023.107064","journal-title":"Bioorg Chem"},{"issue":"4","key":"11054_CR32","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1021\/acs.jmedchem.2c01996","volume":"66","author":"Y Chen","year":"2023","unstructured":"Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M et al (2023) Structure-directed discovery of potent soluble epoxide hydrolase inhibitors for the treatment of inflammatory diseases. J Med Chem 66(4):2979\u20133009. https:\/\/doi.org\/10.1021\/acs.jmedchem.2c01996","journal-title":"J Med Chem"},{"issue":"24","key":"11054_CR33","doi-asserted-by":"publisher","first-page":"11080","DOI":"10.1021\/acs.jmedchem.9b01010","volume":"62","author":"F Jiang","year":"2019","unstructured":"Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D et al (2019) Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-terminal Domain (BET) inhibitors with selectivity for the first bromodomain with potential high efficiency against Acute Gouty Arthritis. J Med Chem 62(24):11080\u201311107. https:\/\/doi.org\/10.1021\/acs.jmedchem.9b01010","journal-title":"J Med Chem"},{"key":"11054_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.05.010","volume":"351","author":"Y Liu","year":"2018","unstructured":"Liu Y, Duan C, Chen H, Wang C, Liu X, Qiu M et al (2018) Inhibition of COX-2\/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Toxicol Appl Pharmacol 351:1\u201311. https:\/\/doi.org\/10.1016\/j.taap.2018.05.010","journal-title":"Toxicol Appl Pharmacol"},{"key":"11054_CR35","doi-asserted-by":"publisher","first-page":"991","DOI":"10.12659\/msm.912545","volume":"25","author":"SX Ren","year":"2019","unstructured":"Ren SX, Zhan B, Lin Y, Ma DS, Yan H (2019) Selenium nanoparticles dispersed in Phytochemical exert anti-inflammatory activity by modulating catalase, GPx1, and COX-2 gene expression in a rheumatoid arthritis rat model. Med Sci Monit 25:991\u20131000. https:\/\/doi.org\/10.12659\/msm.912545","journal-title":"Med Sci Monit"},{"issue":"1","key":"11054_CR36","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1080\/13880209.2021.1979595","volume":"59","author":"X Sun","year":"2021","unstructured":"Sun X, Li P, Qu X, Liu W (2021) Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4\/MyD88\/NF-\u03baB pathway. Pharm Biol 59(1):1326\u20131333. https:\/\/doi.org\/10.1080\/13880209.2021.1979595","journal-title":"Pharm Biol"},{"issue":"5","key":"11054_CR37","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.3892\/mmr.2019.10708","volume":"20","author":"S Li","year":"2019","unstructured":"Li S, Li L, Yan H, Jiang X, Hu W, Han N et al (2019) Anti\u2013gouty arthritis and anti\u2013hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep 20(5):4623\u20134633. https:\/\/doi.org\/10.3892\/mmr.2019.10708","journal-title":"Mol Med Rep"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-024-11054-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-024-11054-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-024-11054-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:03:24Z","timestamp":1758600204000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-024-11054-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["11054"],"URL":"https:\/\/doi.org\/10.1007\/s11030-024-11054-w","relation":{},"ISSN":["1381-1991","1573-501X"],"issn-type":[{"value":"1381-1991","type":"print"},{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}