{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:25:35Z","timestamp":1787981135398,"version":"build-2784847793"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Key Research and Development Program of China","award":["2023YFD1400404"],"award-info":[{"award-number":["2023YFD1400404"]}]},{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["32060622"],"award-info":[{"award-number":["32060622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Guizhou Provincial Foundation for Excellent Scholars Program","award":["GCC[2023]069"],"award-info":[{"award-number":["GCC[2023]069"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-025-11288-2","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T05:00:15Z","timestamp":1756789215000},"page":"3881-3894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diversity-oriented optimization of 1,2,4-oxadiazole pharmacophore for the discovery of nematicides"],"prefix":"10.1007","volume":"30","author":[{"given":"Yuqin","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhai","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"11288_CR1","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3390\/plants13192813","volume":"13","author":"BK Meresa","year":"2024","unstructured":"Meresa BK, Matthys J, Kyndt T (2024) Biochemical defence of plants against parasitic nematodes. Plants 13:2813. https:\/\/doi.org\/10.3390\/plants13192813","journal-title":"Plants"},{"key":"11288_CR2","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/ps.684","volume":"59","author":"DJ Chitwood","year":"2003","unstructured":"Chitwood DJ (2003) Research on plant-parasitic nematode biology conducted by the United States Department of Agriculture-Agricultural Research Service. Pest Manag Sci 59:748\u2013753. https:\/\/doi.org\/10.1002\/ps.684","journal-title":"Pest Manag Sci"},{"key":"11288_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133191","volume":"1264","author":"DK Chen","year":"2022","unstructured":"Chen DK, Yang HP, Li Z, Maienfisch P, Xu XY (2022) Design, synthesis and nematocidal activities of trifluorobutene hydroxamic acid derivatives against Meloidogyne incognita. J Mol Struct 1264:133191. https:\/\/doi.org\/10.1016\/j.molstruc.2022.133191","journal-title":"J Mol Struct"},{"key":"11288_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1080\/09064710.2013.794858","volume":"63","author":"MA Hassan","year":"2013","unstructured":"Hassan MA, Pham TH, Shi HL, Zheng JW (2013) Nematodes threats to global food security. Acta Agric Scand Sect B Soil Plant Sci 63:420\u2013425. https:\/\/doi.org\/10.1080\/09064710.2013.794858","journal-title":"Acta Agric Scand Sect B Soil Plant Sci"},{"key":"11288_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1046\/j.1364-3703.2003.00170.x","volume":"4","author":"P Abad","year":"2003","unstructured":"Abad P, Favery B, Rosso MN, Castagnone-Sereno P (2003) Root-knot nematode parasitism and host response: molecular basis of a sophisticated interaction. Mol Plant Pathol 4:217\u2013224. https:\/\/doi.org\/10.1046\/j.1364-3703.2003.00170.x","journal-title":"Mol Plant Pathol"},{"key":"11288_CR6","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nbt.1482","volume":"26","author":"P Abad","year":"2008","unstructured":"Abad P, Gouzy J, Aury JM, Castagnone-Sereno P, Danchin EGJ, Deleury E, Perfus-Barbeoch L, Anthouard V, Weissenbach J, Wincker P et al (2008) Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nat Biotechnol 26:909\u2013915. https:\/\/doi.org\/10.1038\/nbt.1482","journal-title":"Nat Biotechnol"},{"issue":"9","key":"11288_CR7","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/mpp.12057","volume":"14","author":"JT Jones","year":"2013","unstructured":"Jones JT, Haegeman A, Danchin EGJ, Gaur HS, Helder J, Jones MGK, Kikuchi T, Manzanilla-L\u00f3pez R, Palomares-Rius JE, Wesemael WML et al (2013) Top 10 plant-parasitic nematodes in molecular plant pathology. Mol Plant Pathol 14(9):946\u2013961. https:\/\/doi.org\/10.1111\/mpp.12057","journal-title":"Mol Plant Pathol"},{"key":"11288_CR8","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.3390\/f15091556","volume":"15","author":"L Fonseca","year":"2024","unstructured":"Fonseca L, Silva H, Cardoso JMS, Esteves I, Maleita C, Lopes S, Abrantes I (2024) Bursaphelenchus xylophilus in Pinus sylvestris\u2014The First Report in Europe. Forests 15:1556. https:\/\/doi.org\/10.3390\/f15091556","journal-title":"Forests"},{"key":"11288_CR9","doi-asserted-by":"publisher","first-page":"11576","DOI":"10.1038\/s41598-020-68503-3","volume":"10","author":"T Ekino","year":"2020","unstructured":"Ekino T, Kirino H, Kanzaki N, Shinya R (2020) Ultrastructural plasticity in the plant-parasitic nematode. Bursaphelenchus xylophilus Sci Rep 10:11576. https:\/\/doi.org\/10.1038\/s41598-020-68503-3","journal-title":"Bursaphelenchus xylophilus Sci Rep"},{"key":"11288_CR10","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s10658-019-01692-4","volume":"154","author":"ES \u00c7elik","year":"2019","unstructured":"\u00c7elik ES, Devran Z (2019) Identification and quantification of Aphelenchoides besseyi from rice using qPCR. Eur J Plant Pathol 154:691\u2013703. https:\/\/doi.org\/10.1007\/s10658-019-01692-4","journal-title":"Eur J Plant Pathol"},{"key":"11288_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066011","volume":"8","author":"X Cheng","year":"2013","unstructured":"Cheng X, Xiang Y, Xie H, Xu CL, Xie TF, Zhang C, Li Y (2013) Molecular characterization and functions of fatty acid and retinoid binding protein gene (Ab-far-1) in Aphelenchoides besseyi. PLoS ONE 8:e66011. https:\/\/doi.org\/10.1371\/journal.pone.0066011","journal-title":"PLoS ONE"},{"key":"11288_CR12","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1038\/s41598-022-05998-y","volume":"12","author":"JK Hsu","year":"2022","unstructured":"Hsu JK, Weng CW, Chen JJW, Chen PJ (2022) The ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment. Sci Rep 12:1975. https:\/\/doi.org\/10.1038\/s41598-022-05998-y","journal-title":"Sci Rep"},{"key":"11288_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2019.104975","volume":"127","author":"ES \u00c7elik","year":"2020","unstructured":"\u00c7elik ES, T\u00fclek A, Devran Z (2020) Development of a novel scale based on qPCR for rapid and accurate prediction of the number of Aphelenchoides besseyi in paddy rice. Crop Prot 127:104975. https:\/\/doi.org\/10.1016\/j.cropro.2019.104975","journal-title":"Crop Prot"},{"key":"11288_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240805","volume":"15","author":"L Chen","year":"2020","unstructured":"Chen L, Xu MC, Wang CX, Zheng JS, Huang GQ, Chen F, Peng DH, Sun M (2020) Multi-copy alpha-amylase genes are crucial for Ditylenchus destructor to parasitize the plant host. PLoS ONE 15:e0240805. https:\/\/doi.org\/10.1371\/journal.pone.0240805","journal-title":"PLoS ONE"},{"issue":"12","key":"11288_CR15","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2016.4602","volume":"14","author":"M Jeger","year":"2016","unstructured":"Jeger M, Bragard C, Cafer D, Candresse T, Chatzivassiliou E, Dehnen-Schmutz K, Gilioli G, Gregoire JC, Miret JAJ, Urek G et al (2016) Risk to plant health of Ditylenchus destructor for the EU territory. EFSA J 14(12):e04602. https:\/\/doi.org\/10.2903\/j.efsa.2016.4602","journal-title":"EFSA J"},{"key":"11288_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1021\/acs.jafc.4c00103","volume":"72","author":"N Yadav","year":"2024","unstructured":"Yadav N, Kumar R, Sangwan S, Dhanda V, Rani R, Devi S, Duhan A, Sindhu J, Chauhan S, Malik VK, Yadav S, Banakar P (2024) Design, synthesis, nematocidal evaluation, and molecular docking study of pyrano[3,2-c]pyridones against Meloidogyne incognita. J Agric Food Chem 72:12\u201315522. https:\/\/doi.org\/10.1021\/acs.jafc.4c00103","journal-title":"J Agric Food Chem"},{"key":"11288_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005502","volume":"11","author":"AR Burns","year":"2017","unstructured":"Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ (2017) The novel nematicide wact-86 interacts with aldicarb to kill nematodes. PLOS Negl Trop Dis 11:e0005502. https:\/\/doi.org\/10.1371\/journal.pntd.0005502","journal-title":"PLOS Negl Trop Dis"},{"key":"11288_CR18","doi-asserted-by":"publisher","first-page":"12175","DOI":"10.1021\/acs.jafc.0c02871","volume":"68","author":"JX Chen","year":"2020","unstructured":"Chen JX, Li QX, Song BA (2020) Chemical Nematicides: Recent Research Progress and Outlook. J Agric Food Chem 68:12175\u201312188. https:\/\/doi.org\/10.1021\/acs.jafc.0c02871","journal-title":"J Agric Food Chem"},{"key":"11288_CR19","doi-asserted-by":"publisher","first-page":"8672","DOI":"10.1021\/acs.jafc.8b01940","volume":"66","author":"B Torto","year":"2018","unstructured":"Torto B, Cortada L, Murungi LK, Haukeland S, Coyne DL (2018) Management of cyst and root knot nematodes: a chemical ecology perspective. J Agric Food Chem 66:8672\u20138678. https:\/\/doi.org\/10.1021\/acs.jafc.8b01940","journal-title":"J Agric Food Chem"},{"key":"11288_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.02.007","volume":"165","author":"E Feist","year":"2020","unstructured":"Feist E, Kearn J, Gaihre Y, O\u2019Connor V, Holden-Dye L (2020) The distinct profiles of the inhibitory effects of fluensulfone, abamectin, aldicarb and fluopyram on Globodera pallida hatching. Pestic Biochem Physiol 165:104541. https:\/\/doi.org\/10.1016\/j.pestbp.2020.02.007","journal-title":"Pestic Biochem Physiol"},{"key":"11288_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1574-6941.2007.00349.x","volume":"61","author":"BY Tian","year":"2007","unstructured":"Tian BY, Yang JK, Zhang KQ (2007) Bacteria used in the biological control of plant-parasitic nematodes: populations, mechanisms of action, and future prospects. FEMS Microbiol Ecol 61:197\u2013213. https:\/\/doi.org\/10.1111\/j.1574-6941.2007.00349.x","journal-title":"FEMS Microbiol Ecol"},{"key":"11288_CR22","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1021\/jf049094c","volume":"52","author":"SJ Qin","year":"2004","unstructured":"Qin SJ, Gan JY, Liu WP, Becker JO (2004) Degradation and absorption of fosthiazate in soil. J Agric Food Chem 52:6239\u20136242. https:\/\/doi.org\/10.1021\/jf049094c","journal-title":"J Agric Food Chem"},{"key":"11288_CR23","doi-asserted-by":"publisher","first-page":"11954","DOI":"10.1038\/s41598-022-15782-7","volume":"12","author":"ASS Schleker","year":"2022","unstructured":"Schleker ASS, Rist M, Matera C, Damijonaitis A, Collienne U, Matsuoka K, Habash SS, Twelker K, Gutbrod O, Grundler FMW et al (2022) Mode of action of fuopyram in plant-parasitic nematode. Sci Rep 12:11954. https:\/\/doi.org\/10.1038\/s41598-022-15782-7","journal-title":"Sci Rep"},{"key":"11288_CR24","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1039\/C6OB00936K","volume":"14","author":"AP Taylor","year":"2016","unstructured":"Taylor AP, Robinson RP, Fobian YM, Blakemore DC, Jonesb LH, Fadeyi O (2016) Modern advances in heterocyclic chemistry in drug discovery. Org Biomol Chem 14:6611\u20136637. https:\/\/doi.org\/10.1039\/C6OB00936K","journal-title":"Org Biomol Chem"},{"key":"11288_CR25","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.ejmech.2016.12.016","volume":"126","author":"SC Karad","year":"2017","unstructured":"Karad SC, Purohit VB, Thummar RP, Vaghasiya BK, Kamani RD, Thakor P, Thakkar VR, Thakkar SS, Ray A, Raval DK (2017) Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1, 2, 4-oxadiazole motifs. Eur J Med Chem 126:894\u2013909. https:\/\/doi.org\/10.1016\/j.ejmech.2016.12.016","journal-title":"Eur J Med Chem"},{"key":"11288_CR26","doi-asserted-by":"publisher","first-page":"127373","DOI":"10.1016\/j.bmcl.2020.127373","volume":"30","author":"YY Zhang","year":"2020","unstructured":"Zhang YY, Zhang QQ, Zhang J, Song JL, Li JC, Han K, Huang JT, Jiang CS, Zhang H (2020) Synthesis and evaluation of 1,2,4-oxadiazole derivatives as potential anti-inflammatory agents by inhibiting NF-\u03baB signaling pathway in LPS-stimulated RAW 2647 cells. Bioorg Med Chem Lett 30:127373. https:\/\/doi.org\/10.1016\/j.bmcl.2020.127373","journal-title":"Bioorg Med Chem Lett"},{"key":"11288_CR27","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.3390\/ijms22052367","volume":"22","author":"S Yang","year":"2021","unstructured":"Yang S, Ren CL, Ma TY, Zou WQ, Dai L, Tian XY, Liu XH, Tan CX (2021) 1,2,4-Oxadiazole-based bio-isosteres of benzamides: synthesis, biological activity and toxicity to zebrafsh embryo. Int J Mol Sci 22:2367. https:\/\/doi.org\/10.3390\/ijms22052367","journal-title":"Int J Mol Sci"},{"key":"11288_CR28","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.14102\/j.cnki.0254-5861.2014.10.029","volume":"10","author":"TH Huang","year":"2014","unstructured":"Huang TH, Chen H, Chen J, Zhang AD (2014) Syntheses, crystal structures, and biological activities of two 5-pyrimidinyl-1,2,4-oxadiazoles. Chin J Struc Chem 10:1455\u20131459. https:\/\/doi.org\/10.14102\/j.cnki.0254-5861.2014.10.029","journal-title":"Chin J Struc Chem"},{"key":"11288_CR29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1021\/bk-2015-1204.ch010","volume":"10","author":"U Slomczynska","year":"2015","unstructured":"Slomczynska U, South MS, Bunkers GJ, Edgecomb D, Wyse-Pester D, Selness S, Ding YW, Christiansen J, Ediger K, McCarter J et al (2015) Tioxazafen: a new broad-spectrum seed treatment nematicide. J Am Chem Soc 10:129\u2013147. https:\/\/doi.org\/10.1021\/bk-2015-1204.ch010","journal-title":"J Am Chem Soc"},{"key":"11288_CR30","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13065-020-00722-1","volume":"14","author":"LZ Zhu","year":"2020","unstructured":"Zhu LZ, Zeng HN, Liu D, Fu Y, Wu Q, Song BA, Gan XH (2020) Design, synthesis, and biological activity of novel 1,2,4-oxadiazole derivatives. BMC Chem 14:68. https:\/\/doi.org\/10.1186\/s13065-020-00722-1","journal-title":"BMC Chem"},{"key":"11288_CR31","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1080\/10426507.2022.2046580","volume":"197","author":"D Liu","year":"2022","unstructured":"Liu D, Wang ZX, Zhou JJ, Gan XH (2022) Design, synthesis and nematocidal activity of novel 1,2,4-oxadiazole derivatives with a 1,3,4-thiadiazole amide moiety. Phosphorus Sulfur 197:934\u2013942. https:\/\/doi.org\/10.1080\/10426507.2022.2046580","journal-title":"Phosphorus Sulfur"},{"key":"11288_CR32","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3390\/ijms23031596","volume":"23","author":"D Liu","year":"2022","unstructured":"Liu D, Luo L, Wang ZX, Ma XY, Gan XH (2022) Design, synthesis and antifungal\/nematocidal activity of novel 1,2,4-oxadiazole derivatives containing amide fragments. Int J Mol Sci 23:1596. https:\/\/doi.org\/10.3390\/ijms23031596","journal-title":"Int J Mol Sci"},{"key":"11288_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-024-10992-9","author":"YQ Ou","year":"2024","unstructured":"Ou YQ, Guo X, Zhang Q, Zhang W, Gan XH (2024) Design, synthesis, and nematocidal activity of novel 1,2,4-oxadiazole derivatives containing amide fragments. Mol Divers. https:\/\/doi.org\/10.1007\/s11030-024-10992-9","journal-title":"Mol Divers"},{"key":"11288_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.943062","volume":"10","author":"L Luo","year":"2022","unstructured":"Luo L, Liu D, Lan SC, Gan XH (2022) Design, synthesis, and biological activity of novel chalcone derivatives containing an 1,2,4-oxadiazole moiety. Front Chem 10:943062. https:\/\/doi.org\/10.3389\/fchem.2022.943062","journal-title":"Front Chem"},{"key":"11288_CR35","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.3390\/ijms24065773","volume":"24","author":"L Luo","year":"2023","unstructured":"Luo L, Ou YQ, Zhang Q, Gan XH (2023) Discovery of 1,2,4-oxadiazole derivatives containing haloalkyl as potential acetylcholine receptor nematicides. Int J Mol Sci 24:5773. https:\/\/doi.org\/10.3390\/ijms24065773","journal-title":"Int J Mol Sci"},{"key":"11288_CR36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1021\/acs.jafc.4c07806","volume":"73","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Liu D, Ou YQ, Gan XH (2025) 1,2,4-Oxadiazole-5-carboxylic acid derivatives as safe seed treatment nematicides. J Agric Food Chem 73:169\u2013179. https:\/\/doi.org\/10.1021\/acs.jafc.4c07806","journal-title":"J Agric Food Chem"},{"key":"11288_CR37","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.1021\/acs.jafc.5b01762","volume":"63","author":"GL Wang","year":"2015","unstructured":"Wang GL, Chen XL, Deng YY, Li Z, Xu XY (2015) Synthesis and nematicidal activities of 1, 2, 3-benzotriazin-4-one derivatives against Meloidogyne incognita. J Agric Food Chem 63:6883\u20136889. https:\/\/doi.org\/10.1021\/acs.jafc.5b01762","journal-title":"J Agric Food Chem"},{"key":"11288_CR38","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/jhet.4767","volume":"61","author":"HY Song","year":"2024","unstructured":"Song HY, Wang S, Cai QF, Chen JX (2024) Research progress of triazole derivatives in the discovery of agricultural chemicals. J Heterocycl Chem 61:365\u2013386. https:\/\/doi.org\/10.1002\/jhet.4767","journal-title":"J Heterocycl Chem"},{"key":"11288_CR39","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/j.bmcl.2019.06.030","volume":"29","author":"YJ Wang","year":"2019","unstructured":"Wang YJ, Zhang J, He FC, Gan XH, Song BA, Hu DY (2019) Design, synthesis, bioactivity and mechanism of dithioacetal derivatives containing dioxyether moiety. Bioorg Med Chem Lett 29:2218\u20132223. https:\/\/doi.org\/10.1016\/j.bmcl.2019.06.030","journal-title":"Bioorg Med Chem Lett"},{"key":"11288_CR40","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.3390\/molecules28135041","volume":"28","author":"T Kosmalski","year":"2023","unstructured":"Kosmalski T, Kupczyk D, Baumgart S, Paprocka R, Studzi\u0144ska R (2023) A Review of Biologically Active Oxime Ethers. Molecules 28:5041. https:\/\/doi.org\/10.3390\/molecules28135041","journal-title":"Molecules"},{"key":"11288_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126774","volume":"30","author":"GQ Sui","year":"2020","unstructured":"Sui GQ, Xu D, Luo TL, Guo HH, Sheng G, Yin DR, Zhou WM (2020) Design, synthesis and antifungal activity of amide and imine derivatives containing a kakuol moiety. Bioorg Med Chem Lett 30:126774. https:\/\/doi.org\/10.1016\/j.bmcl.2019.126774","journal-title":"Bioorg Med Chem Lett"},{"key":"11288_CR42","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.pestbp.2019.10.012","volume":"163","author":"SK Rajasekharan","year":"2020","unstructured":"Rajasekharan SK, Kim S, Kim JC, Lee J (2020) Nematicidal activity of 5-iodoindole against root-knot nematodes. Pestic Biochem Phys 163:76\u201383. https:\/\/doi.org\/10.1016\/j.pestbp.2019.10.012","journal-title":"Pestic Biochem Phys"},{"key":"11288_CR43","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1002\/ps.5272","volume":"75","author":"M Liu","year":"2018","unstructured":"Liu M, Hwang BS, Jin CZ, Li WJ, Park DJ, Seo ST, Kim CJ (2018) Screening, isolation and evaluation of a nematicidal compound from actinomycetes against the pine wood nematode, Bursaphelenchus xylophilus. Pest Manag Sci 75:1585\u20131593. https:\/\/doi.org\/10.1002\/ps.5272","journal-title":"Pest Manag Sci"},{"key":"11288_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.131830","volume":"286","author":"Y Liu","year":"2022","unstructured":"Liu Y, Zhang WP, Wang Y, Liu HM, Zhang SA, Ji XX (2022) Oxidative stress, intestinal damage, and cell apoptosis: Toxicity induced by fluopyram in Caenorhabditis elegans. Chemosphere 286:131830. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131830","journal-title":"Chemosphere"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-025-11288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-025-11288-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-025-11288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:33:39Z","timestamp":1779536019000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-025-11288-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["11288"],"URL":"https:\/\/doi.org\/10.1007\/s11030-025-11288-2","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"24 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}