{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:18:25Z","timestamp":1783163905731,"version":"3.54.6"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"the National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2025-00513239"],"award-info":[{"award-number":["RS-2025-00513239"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Establishing the Foundation for In Silico Industrialization in Uiseong-gun, Gyeongsangbuk-do"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-026-11525-2","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T15:13:50Z","timestamp":1774797230000},"page":"6221-6237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Als3 adhesin of clinically relevant Candida species using natural carotenoids: an in-silico study"],"prefix":"10.1007","volume":"30","author":[{"given":"Ziyad","family":"Abdelaal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath Reddy","family":"Boya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"11525_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00629","author":"L Mukaremera","year":"2017","unstructured":"Mukaremera L, Lee KK, Mora-Montes HM, Gow NAR (2017) Candida albicans yeast, pseudohyphal, and hyphal morphogenesis differentially affects immune recognition. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.00629","journal-title":"Front Immunol"},{"issue":"1","key":"11525_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-025-04447-w","volume":"25","author":"KB Al-Monofy","year":"2025","unstructured":"Al-Monofy KB, Abdelaziz AA, Abo-Kamar AM, Al-Madboly LA, Farghali MH (2025) The dual antifungal and antibiofilm activities of \u03b2-carotene against multidrug-resistant Candida albicans induce wound healing in a diabetic rat model: an in vitro and in vivo study. BMC Microbiol 25(1):747. https:\/\/doi.org\/10.1186\/s12866-025-04447-w","journal-title":"BMC Microbiol"},{"issue":"6","key":"11525_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11060718","volume":"11","author":"N Barantsevich","year":"2022","unstructured":"Barantsevich N, Barantsevich E (2022) Diagnosis and teatment of invasive candidiasis. Antibiotics 11(6):718. https:\/\/doi.org\/10.3390\/antibiotics11060718","journal-title":"Antibiotics"},{"issue":"1","key":"11525_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10010081","volume":"10","author":"AM El-Baz","year":"2021","unstructured":"El-Baz AM, Mosbah RA, Goda RM, Mansour B, Sultana T, Dahms TES et al (2021) Back to nature: combating Candida albicans biofilm, phospholipase and hemolysin using plant essential oils. Antibiotics 10(1):81. https:\/\/doi.org\/10.3390\/antibiotics10010081","journal-title":"Antibiotics"},{"issue":"4","key":"11525_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13040093","volume":"13","author":"DC Mallick","year":"2025","unstructured":"Mallick DC, Kaushik N, Goyal L, Mallick L, Singh P (2025) A comprehensive review of candidemia and invasive candidiasis in adults: focus on the emerging multidrug-resistant fungus Candida auris. Diseases 13(4):93. https:\/\/doi.org\/10.3390\/diseases13040093","journal-title":"Diseases"},{"issue":"1","key":"11525_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00485-2","volume":"11","author":"R Jothi","year":"2021","unstructured":"Jothi R, Sangavi R, Kumar P, Pandian SK, Gowrishankar S (2021) Catechol thwarts virulent dimorphism in Candida albicans and potentiates the antifungal efficacy of azoles and polyenes. Sci Rep 11(1):21049. https:\/\/doi.org\/10.1038\/s41598-021-00485-2","journal-title":"Sci Rep"},{"key":"11525_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.638609","author":"T Atriwal","year":"2021","unstructured":"Atriwal T, Azeem K, Husain FM, Hussain A, Khan MN, Alajmi MF et al (2021) Mechanistic understanding of Candida albicans biofilm formation and approaches for its inhibition. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2021.638609","journal-title":"Front Microbiol"},{"issue":"7","key":"11525_CR8","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1007\/s12033-023-00796-x","volume":"66","author":"D Kumar","year":"2024","unstructured":"Kumar D, Kumar A (2024) Molecular determinants involved in Candida albicans biofilm formation and regulation. Mol Biotechnol 66(7):1640\u20131659. https:\/\/doi.org\/10.1007\/s12033-023-00796-x","journal-title":"Mol Biotechnol"},{"key":"11525_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.544480","author":"C Rodr\u00edguez-Cerdeira","year":"2020","unstructured":"Rodr\u00edguez-Cerdeira C, Mart\u00ednez-Herrera E, Carnero-Gregorio M, L\u00f3pez-Barcenas A, Fabbrocini G, Fida M et al (2020) Pathogenesis and clinical relevance of Candida biofilms in vulvovaginal candidiasis. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.544480","journal-title":"Front Microbiol"},{"issue":"4","key":"11525_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14040350","volume":"14","author":"U Ram\u00edrez-Sotelo","year":"2025","unstructured":"Ram\u00edrez-Sotelo U, G\u00f3mez-Gaviria M, Mora-Montes HM (2025) Signaling pathways regulating dimorphism in medically relevant fungal species. Pathogens 14(4):350. https:\/\/doi.org\/10.3390\/pathogens14040350","journal-title":"Pathogens"},{"key":"11525_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.855229","author":"VE Glazier","year":"2022","unstructured":"Glazier VE (2022) EFG1, everyone\u2019s favorite gene in Candida albicans: a comprehensive literature review. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2022.855229","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"11525_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/jof11050398","volume":"11","author":"M Meral Ocal","year":"2025","unstructured":"Meral Ocal M, Aydin M, Sumlu E, Korucu EN, Ozturk A (2025) Myricetin exerts antibiofilm effects on Candida albicans by targeting the RAS1\/cAMP\/EFG1 pathway and disruption of the hyphal network. J Fungi 11(5):398. https:\/\/doi.org\/10.3390\/jof11050398","journal-title":"J Fungi"},{"issue":"4","key":"11525_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13040310","volume":"13","author":"E Sumlu","year":"2024","unstructured":"Sumlu E, Aydin M, Korucu EN, Alyar S, Nsangou AM (2024) Artemisinin may disrupt hyphae formation by suppressing biofilm-related genes of Candida albicans: In vitro and in silico approaches. Antibiotics 13(4):310. https:\/\/doi.org\/10.3390\/antibiotics13040310","journal-title":"Antibiotics"},{"issue":"7","key":"11525_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10070859","volume":"10","author":"EWL Chow","year":"2021","unstructured":"Chow EWL, Pang LM, Wang Y (2021) From Jekyll to Hyde: The yeast\u2013hyphal transition of Candida albicans. Pathogens 10(7):859. https:\/\/doi.org\/10.3390\/pathogens10070859","journal-title":"Pathogens"},{"issue":"1","key":"11525_CR15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/mmi.14148","volume":"111","author":"G Huang","year":"2019","unstructured":"Huang G, Huang Q, Wei Y, Wang Y, Du H (2019) Multiple roles and diverse regulation of the Ras\/cAMP\/protein kinase a pathway in Candida albicans. Mol Microbiol 111(1):6\u201316. https:\/\/doi.org\/10.1111\/mmi.14148","journal-title":"Mol Microbiol"},{"key":"11525_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00280","author":"LL Hoyer","year":"2016","unstructured":"Hoyer LL, Cota E (2016) Candida albicans agglutinin-like sequence (Als) family vignettes: a review of Als protein structure and function [Review]. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2016.00280","journal-title":"Front Microbiol"},{"key":"11525_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.655242","author":"K Deng","year":"2021","unstructured":"Deng K, Jiang W, Jiang Y, Deng Q, Cao J, Yang W et al (2021) ALS3 expression as an indicator for Candida albicans biofilm formation and drug resistance [Original Research]. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2021.655242","journal-title":"Front Microbiol"},{"key":"11525_CR18","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00024-20","author":"J Gong","year":"2020","unstructured":"Gong J, Bing J, Guan G, Nobile CJ, Huang G (2020) The Als3 cell wall adhesin plays a critical role in human serum amyloid A1-induced cell death and aggregation in Candida albicans. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/aac.00024-20","journal-title":"Antimicrob Agents Chemother"},{"key":"11525_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ejphar.2018.10.016","volume":"842","author":"DR Silva","year":"2019","unstructured":"Silva DR, de Sardi JCO, Freires IA, Silva ACB, Rosalen PL (2019) In silico approaches for screening molecular targets in Candida albicans: a proteomic insight into drug discovery and development. Eur J Pharmacol 842:64\u201369. https:\/\/doi.org\/10.1016\/j.ejphar.2018.10.016","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"11525_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/jof11080603","volume":"11","author":"I Kilbas","year":"2025","unstructured":"Kilbas I, Kahraman Kilbas EP, Horhat FG, Ciftci IH (2025) Twenty-year course of antifungal resistance in Candida albicans in T\u00fcrkiye: a systematic review and meta-analysis. J Fungi 11(8):603. https:\/\/doi.org\/10.3390\/jof11080603","journal-title":"J Fungi"},{"key":"11525_CR21","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2411.11076","author":"D Kim","year":"2025","unstructured":"Kim D, Kim J-S, Bai X, Zhang J, Park M, Lee U et al (2025) Development of miniprotein-type inhibitors of biofilm formation in Candida albicans and Candida auris. J Microbiol Biotechnol. https:\/\/doi.org\/10.4014\/jmb.2411.11076","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"11525_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02929-0","volume":"20","author":"SA Lone","year":"2020","unstructured":"Lone SA, Ahmad A (2020) Inhibitory effect of novel Eugenol Tosylate congeners on pathogenicity of Candida albicans. BMC Complement Med Ther 20(1):131. https:\/\/doi.org\/10.1186\/s12906-020-02929-0","journal-title":"BMC Complement Med Ther"},{"key":"11525_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioflm.2023.100126","author":"OH Ajetunmobi","year":"2023","unstructured":"Ajetunmobi OH, Badali H, Romo JA, Ramage G, Lopez-Ribot JL (2023) Antifungal therapy of Candida biofilms: Past, present and future. Biofilm. https:\/\/doi.org\/10.1016\/j.bioflm.2023.100126","journal-title":"Biofilm"},{"key":"11525_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29050967","author":"Y Li","year":"2024","unstructured":"Li Y, Zhao Y, Zhang H, Ding Z, Han J (2024) The application of natural carotenoids in multiple fields and their encapsulation technology: a review. Molecules. https:\/\/doi.org\/10.3390\/molecules29050967","journal-title":"Molecules"},{"key":"11525_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-025-02847-1","author":"KB Al-Monofy","year":"2025","unstructured":"Al-Monofy KB, Farghali MH, Al-Madboly LA, Kamer AMA, Abdelaziz AA (2025) Advances in biomanufacturing and recent biological applications of the fundamental bacterial carotenoids: a comprehensive review. Microb Cell Fact. https:\/\/doi.org\/10.1186\/s12934-025-02847-1","journal-title":"Microb Cell Fact"},{"key":"11525_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.58209\/ijwph.15.2.167","volume":"15","author":"N Abu-Mejdad","year":"2023","unstructured":"Abu-Mejdad N, Alsaadoon A (2023) Efficiency of fungal beta- carotene against some causative agents of dermatomycoses. Iran J War Public Health 15:167\u2013175. https:\/\/doi.org\/10.58209\/ijwph.15.2.167","journal-title":"Iran J War Public Health"},{"issue":"D1","key":"11525_CR27","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1093\/nar\/gkae1063","volume":"53","author":"V Chandrasekhar","year":"2024","unstructured":"Chandrasekhar V, Rajan K, Kanakam, Sri Ram S, Sharma N, Wei\u00dfenborn V, Schaub J et al (2024) COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database. Nucleic Acids Res 53(D1):634\u2013643. https:\/\/doi.org\/10.1093\/nar\/gkae1063","journal-title":"Nucleic Acids Res"},{"key":"11525_CR28","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bax004","author":"J Yabuzaki","year":"2017","unstructured":"Yabuzaki J (2017) Carotenoids database: structures, chemical fingerprints and distribution among organisms. Database. https:\/\/doi.org\/10.1093\/database\/bax004","journal-title":"Database"},{"issue":"2","key":"11525_CR29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1021\/ci500588j","volume":"55","author":"T Sander","year":"2015","unstructured":"Sander T, Freyss J, von Korff M, Rufener C (2015) DataWarrior: an open-source program for chemistry aware data visualization and analysis. J Chem Inf Model 55(2):460\u2013473. https:\/\/doi.org\/10.1021\/ci500588j","journal-title":"J Chem Inf Model"},{"issue":"1","key":"11525_CR30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H (2000) The protein data bank. Nucleic Acids Res 28(1):235\u2013242. https:\/\/doi.org\/10.1093\/nar\/28.1.235","journal-title":"Nucleic Acids Res"},{"issue":"26","key":"11525_CR31","doi-asserted-by":"publisher","first-page":"18401","DOI":"10.1074\/jbc.M114.547877","volume":"289","author":"J Lin","year":"2014","unstructured":"Lin J, Oh S-H, Jones R, Garnett JA, Salgado PS, Rusnakova S et al (2014) The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells. J Biol Chem 289(26):18401\u201318412. https:\/\/doi.org\/10.1074\/jbc.M114.547877","journal-title":"J Biol Chem"},{"issue":"W1","key":"11525_CR32","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1093\/nar\/gkae415","volume":"52","author":"B Ye","year":"2024","unstructured":"Ye B, Tian W, Wang B, Liang J (2024) CASTpFold: computed atlas of surface topography of the universe of protein folds. Nucleic Acids Res 52(W1):194\u2013199. https:\/\/doi.org\/10.1093\/nar\/gkae415","journal-title":"Nucleic Acids Res"},{"key":"11525_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1339501","author":"Z Feng","year":"2024","unstructured":"Feng Z, Lu H, Jiang Y (2024) Promising immunotherapeutic targets for treating candidiasis. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2024.1339501","journal-title":"Front Cell Infect Microbiol"},{"key":"11525_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2023.127537","volume":"278","author":"BR Boya","year":"2024","unstructured":"Boya BR, Lee J-H, Lee J (2024) Antimicrobial and antibiofilm activities of chromone derivatives against uropathogenic Escherichia coli. Microbiol Res 278:127537. https:\/\/doi.org\/10.1016\/j.micres.2023.127537","journal-title":"Microbiol Res"},{"key":"11525_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad114","author":"T Wang","year":"2023","unstructured":"Wang T, Pan M, Bao M, Bu Q, Yang R, Yang Y et al (2023) Ethyl caffeate combined with fluconazole exhibits efficacy against azole-resistant oropharyngeal candidiasis via the EFGR\/JNK\/c-JUN signaling pathway. Med Mycol. https:\/\/doi.org\/10.1093\/mmy\/myad114","journal-title":"Med Mycol"},{"key":"11525_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116136","volume":"38","author":"MM Alam","year":"2021","unstructured":"Alam MM, Malebari AM, Syed N, Neamatallah T, Almalki ASA, Elhenawy AA et al (2021) Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells. Bioorg Med Chem 38:116136. https:\/\/doi.org\/10.1016\/j.bmc.2021.116136","journal-title":"Bioorg Med Chem"},{"issue":"32","key":"11525_CR37","doi-asserted-by":"publisher","first-page":"36441","DOI":"10.1021\/acsomega.5c04793","volume":"10","author":"J-e Yang","year":"2025","unstructured":"Yang J-e, Lee J-H, Boya BR, Kim Y-G, Byun Y, Lee J (2025) Novel pyrone-based biofilm inhibitors against azole-resistant Candida albicans. ACS Omega 10(32):36441\u201336454. https:\/\/doi.org\/10.1021\/acsomega.5c04793","journal-title":"ACS Omega"},{"issue":"10","key":"11525_CR38","doi-asserted-by":"publisher","first-page":"4852","DOI":"10.1021\/acs.jcim.1c00998","volume":"61","author":"PR Arantes","year":"2021","unstructured":"Arantes PR, Pol\u00eato MD, Pedebos C, Ligabue-Braun R (2021) Making it rain: cloud-based molecular simulations for everyone. J Chem Inf Model 61(10):4852\u20134856. https:\/\/doi.org\/10.1021\/acs.jcim.1c00998","journal-title":"J Chem Inf Model"},{"key":"11525_CR39","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001308","author":"L da Juv\u00eancio Silva","year":"2021","unstructured":"da Juv\u00eancio Silva L, Dias Barroso FD, Vieira LS, Carlos Mota DR, da Silva Firmino BK, da Rocha Silva C et al (2021) Diazepam\u2019s antifungal activity in fluconazole-resistant Candida spp. and biofilm inhibition in C. albicans: evaluation of the relationship with the proteins Als3 and Sap5. J Med Microbiol. https:\/\/doi.org\/10.1099\/jmm.0.001308","journal-title":"J Med Microbiol"},{"key":"11525_CR40","doi-asserted-by":"publisher","DOI":"10.5812\/jssc-142360","author":"Y SarveAhrabi","year":"2023","unstructured":"SarveAhrabi Y, Nejati Khoei S (2023) Investigation of some natural products as an inhibitor of agglutinin-like sequence (Als3) from Candida albicans (skin candidiasis): an in-silico study. J Skin Stem Cell. https:\/\/doi.org\/10.5812\/jssc-142360","journal-title":"J Skin Stem Cell"},{"issue":"14","key":"11525_CR41","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.cub.2008.06.034","volume":"18","author":"CJ Nobile","year":"2008","unstructured":"Nobile CJ, Schneider HA, Nett JE, Sheppard DC, Filler SG, Andes DR et al (2008) Complementary adhesin function in C. albicans biofilm formation. Curr Biol 18(14):1017\u20131024. https:\/\/doi.org\/10.1016\/j.cub.2008.06.034","journal-title":"Curr Biol"},{"key":"11525_CR42","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00068-14","author":"C Chan","year":"2014","unstructured":"Chan C, Lipke P (2014) Role of force-sensitive amyloid-like interactions in fungal catch bonding and biofilms. Eukaryot Cell. https:\/\/doi.org\/10.1128\/EC.00068-14","journal-title":"Eukaryot Cell"},{"issue":"17","key":"11525_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202406211","volume":"10","author":"A Laraib","year":"2025","unstructured":"Laraib A, UrRehman S, Jamil S, Zia MA, Muhammad S, Bibi S et al (2025) Aloin as a potential anti-breast cancer agent: insights from molecular docking and density functional theory (DFT) analysis. ChemistrySelect 10(17):e202406211. https:\/\/doi.org\/10.1002\/slct.202406211","journal-title":"ChemistrySelect"},{"key":"11525_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-025-04495-6","author":"A Maqbool","year":"2025","unstructured":"Maqbool A, Laraib A, Ali N, Hassan M, Nadeem MU, Shahzad M et al (2025) Designing structural derivatives of EGCG from Chinese tea for improved antioxidant activity: DFT study. Chem Pap. https:\/\/doi.org\/10.1007\/s11696-025-04495-6","journal-title":"Chem Pap"},{"issue":"18","key":"11525_CR45","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.3390\/molecules27186005","volume":"27","author":"DS Metibemu","year":"2022","unstructured":"Metibemu DS, Ogungbe IV (2022) Carotenoids in drug discovery and medicine: Pathways and molecular targets implicated in human diseases. Molecules 27(18):6005","journal-title":"Molecules"},{"key":"11525_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050064","author":"QT Phan","year":"2007","unstructured":"Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH et al (2007) Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol. https:\/\/doi.org\/10.1371\/journal.pbio.0050064","journal-title":"PLoS Biol"},{"issue":"2","key":"11525_CR47","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1128\/ec.00279-10","volume":"10","author":"Y Liu","year":"2011","unstructured":"Liu Y, Filler SG (2011) Candida albicans Als3, a multifunctional adhesin and invasin. Eukaryot Cell 10(2):168\u2013173. https:\/\/doi.org\/10.1128\/ec.00279-10","journal-title":"Eukaryot Cell"},{"issue":"3","key":"11525_CR48","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1574-695X.2008.00502.x","volume":"55","author":"B Beucher","year":"2009","unstructured":"Beucher B, Marot-Leblond A, Billaud-Nail S, Oh S-H, Hoyer LL, Robert R (2009) Recognition of Candida albicans Als3 by the germ tube-specific monoclonal antibody 3D9.3. FEMS Immunol Med Microbiol 55(3):314\u2013323. https:\/\/doi.org\/10.1111\/j.1574-695X.2008.00502.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"11525_CR49","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01766-19","author":"V Ho","year":"2019","unstructured":"Ho V, Herman-Bausier P, Shaw C, Conrad Karen A, Garcia-Sherman Melissa C, Draghi J et al (2019) An amyloid core sequence in the major Candida albicans adhesin Als1p mediates cell-cell adhesion. MBio. https:\/\/doi.org\/10.1128\/mbio.01766-19","journal-title":"MBio"},{"key":"11525_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.890839","author":"S-H Oh","year":"2022","unstructured":"Oh S-H, Hoyer LL (2022) Assessing Als3 peptide-binding cavity and amyloid-forming region contributions to Candida albicans invasion of human oropharyngeal epithelial cells. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2022.890839","journal-title":"Front Cell Infect Microbiol"},{"key":"11525_CR51","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab089","author":"C Liu","year":"2021","unstructured":"Liu C, Xu C, Du Y, Liu J, Ning Y (2021) Role of agglutinin-like sequence protein 3 (Als3) in the structure and antifungal resistance of Candida albicans biofilms. FEMS Microbiol Lett. https:\/\/doi.org\/10.1093\/femsle\/fnab089","journal-title":"FEMS Microbiol Lett"},{"key":"11525_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158217","author":"M Pasenkiewicz-Gierula","year":"2024","unstructured":"Pasenkiewicz-Gierula M, Hryc J, Markiewicz M (2024) Dynamic and energetic aspects of carotenoids in-and-around model lipid membranes revealed in molecular modelling. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25158217","journal-title":"Int J Mol Sci"},{"key":"11525_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1465055","author":"S Sameh","year":"2024","unstructured":"Sameh S, Elissawy AM, Al-Sayed E, Labib RM, Chang H-W, Yu S-Y et al (2024) Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2024.1465055. ([Original Research])","journal-title":"Front Pharmacol"},{"key":"11525_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.126653","volume":"417","author":"M Gazmeh","year":"2025","unstructured":"Gazmeh M, Khajenoori M, Yousefi-Nasab S, Asl AH (2025) Determining the solubility parameter and thermodynamic properties of beta-carotene in superheated water solvent by experimental and MD simulation methods. J Mol Liq 417:126653. https:\/\/doi.org\/10.1016\/j.molliq.2024.126653","journal-title":"J Mol Liq"},{"key":"11525_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2025.101283","volume":"12","author":"J Gao","year":"2026","unstructured":"Gao J, Wu F, Chen N, Li M, Zhao J, Li J et al (2026) Comparative study of the interaction between \u03b2-lactoglobulin and three carotenoids. J Curr Res Food Sci 12:101283. https:\/\/doi.org\/10.1016\/j.crfs.2025.101283","journal-title":"J Curr Res Food Sci"},{"issue":"1","key":"11525_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13693780701435317","volume":"46","author":"LL Hoyer","year":"2008","unstructured":"Hoyer LL, Green CB, Oh S-H, Zhao X (2008) Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family\u2014A sticky pursuit. Med Mycol 46(1):1\u201315. https:\/\/doi.org\/10.1080\/13693780701435317","journal-title":"Med Mycol"},{"key":"11525_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121506","author":"K Tsuihiji","year":"2022","unstructured":"Tsuihiji K, Honda E, Kojoh K, Katoh S, Taguri T, Yoshimori A et al (2022) Rational strategy for designing peptidomimetic small molecules based on cyclic peptides targeting protein\u2013protein interaction between CTLA-4 and B7-1. Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph15121506","journal-title":"Pharmaceuticals"},{"issue":"3","key":"11525_CR58","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1021\/acs.cgd.0c01648","volume":"21","author":"W Guo","year":"2021","unstructured":"Guo W, Du S, Xu S, Wang Y, Jia L, Liu S et al (2021) Unraveling the molecular mechanisms that influence the color and stability of four lutein crystal forms. Cryst Growth Des 21(3):1762\u20131777. https:\/\/doi.org\/10.1021\/acs.cgd.0c01648","journal-title":"Cryst Growth Des"},{"issue":"3","key":"11525_CR59","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s11224-024-02429-8","volume":"36","author":"FJ Tenorio","year":"2025","unstructured":"Tenorio FJ, Hernandez DA (2025) Conceptual DFT study of antioxidant activity of carotenoids and its radicals. Struct Chem 36(3):975\u2013982. https:\/\/doi.org\/10.1007\/s11224-024-02429-8","journal-title":"Struct Chem"},{"key":"11525_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225553","author":"J Lakey-Beitia","year":"2019","unstructured":"Lakey-Beitia J, Kumar D. J, Hegde ML, Rao KS (2019) Carotenoids as novel therapeutic molecules against neurodegenerative disorders: chemistry and molecular docking analysis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20225553","journal-title":"Int J Mol Sci"},{"issue":"3","key":"11525_CR61","doi-asserted-by":"publisher","first-page":"360","DOI":"10.2174\/1573409911309030012","volume":"9","author":"KY Dharmendra","year":"2013","unstructured":"Dharmendra KY, Vipin M, Jyoti A, Anil KM, Dnyaneshwar UB, Chandan SC et al (2013) Molecular docking and ADME studies of natural compounds of agarwood oil for topical anti-inflammatory activity. Curr Comput Drug Des 9(3):360\u2013370. https:\/\/doi.org\/10.2174\/1573409911309030012","journal-title":"Curr Comput Drug Des"},{"key":"11525_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.31665\/JFB.2023.18360","volume":"24","author":"F Shahidi","year":"2023","unstructured":"Shahidi F, Dissanayaka CS (2023) Binding of carotenoids to proteins: a review. J Food Bioact 24:13\u201328. https:\/\/doi.org\/10.31665\/JFB.2023.18360","journal-title":"J Food Bioact"},{"key":"11525_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.791523","author":"B Short","year":"2021","unstructured":"Short B, Delaney C, McKloud E, Brown JL, Kean R, Litherland GJ et al (2021) Investigating the transcriptome of Candida albicans in a dual-species Staphylococcus aureus biofilm model. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2021.791523","journal-title":"Front Cell Infect Microbiol"},{"key":"11525_CR64","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.70218","author":"P Nithyanand","year":"2025","unstructured":"Nithyanand P, Boya BR, Lee J-H, Lee J (2025) Polymicrobial biofilms: interkingdom interactions, resistance and therapeutic strategies. Microb Biotechnol. https:\/\/doi.org\/10.1111\/1751-7915.70218","journal-title":"Microb Biotechnol"},{"key":"11525_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054872","author":"C Pecoraro","year":"2023","unstructured":"Pecoraro C, Carbone D, Parrino B, Cascioferro S, Diana P (2023) Recent developments in the inhibition of bacterial adhesion as promising anti-virulence strategy. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24054872","journal-title":"Int J Mol Sci"},{"issue":"3","key":"11525_CR66","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2174\/1570163820666230227113802","volume":"20","author":"A Neda","year":"2023","unstructured":"Neda A, Mahboobeh M, Masoud F, Pegah S (2023) Antifungal effect of carrot carotenoids on Candida species. Curr Drug Discov Technol 20(3):16\u201320. https:\/\/doi.org\/10.2174\/1570163820666230227113802","journal-title":"Curr Drug Discov Technol"},{"issue":"3","key":"11525_CR67","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.chom.2019.02.008","volume":"25","author":"JN Witchley","year":"2019","unstructured":"Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM (2019) Candida albicans morphogenesis programs control the balance between gut commensalism and invasive infection. Cell Host Microbe 25(3):432\u2013443. https:\/\/doi.org\/10.1016\/j.chom.2019.02.008","journal-title":"Cell Host Microbe"},{"issue":"1","key":"11525_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00253-025-13469-3","volume":"109","author":"C-H Lee","year":"2025","unstructured":"Lee C-H, Wu C-J, Yen F-Y, Chiang J-Y, Shen T-J, Leu S-J et al (2025) Identification of chicken-derived antibodies targeting the Candida albicans Als3 protein. Appl Microbiol Biotechnol 109(1):1\u201314. https:\/\/doi.org\/10.1007\/s00253-025-13469-3","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"11525_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3690140","volume":"2016","author":"JA Edwards","year":"2016","unstructured":"Edwards JA (2016) Zeaxanthin: review of toxicological data and acceptable daily intake. J Ophthalmol 2016(1):3690140. https:\/\/doi.org\/10.1155\/2016\/3690140","journal-title":"J Ophthalmol"},{"issue":"1","key":"11525_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10915810701876265","volume":"27","author":"KB Harikumar","year":"2008","unstructured":"Harikumar KB, Nimita CV, Preethi KC, Kuttan R, Shankaranarayana ML, Deshpande J (2008) Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). Int J Toxicol 27(1):1\u20139. https:\/\/doi.org\/10.1080\/10915810701876265","journal-title":"Int J Toxicol"},{"issue":"4","key":"11525_CR71","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2174\/1573403X14666180628095918","volume":"14","author":"H Kyriaki","year":"2018","unstructured":"Kyriaki H, George IL (2018) The protective role of Crocus sativus L. (Saffron) against ischemia-reperfusion injury, hyperlipidemia and atherosclerosis: nature opposing cardiovascular diseases. Curr Cardiol Rev 14(4):272\u2013289. https:\/\/doi.org\/10.2174\/1573403X14666180628095918","journal-title":"Curr Cardiol Rev"},{"issue":"2","key":"11525_CR72","doi-asserted-by":"publisher","first-page":"158","DOI":"10.46542\/pe.2024.242.158162","volume":"24","author":"NK Sari","year":"2024","unstructured":"Sari NK, Sriwidodo, Fauzi NI, Diantini A, Prayugo WD (2024) Acute toxicity test of tablets containing \u03b1-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C in female wistar rats. Pharm Educ 24(2):158\u2013162. https:\/\/doi.org\/10.46542\/pe.2024.242.158162","journal-title":"Pharm Educ"},{"key":"11525_CR73","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-3-031-76718-0_7","volume-title":"Computer-aided and machine learning-driven drug design: from theory to applications","author":"RM de Angelo","year":"2024","unstructured":"de Angelo RM, de Sousa DS, da Silva AP, Chiari LPA, da Silva ABF, Honorio KM (2024) Molecular docking: state-of-the-art scoring functions and search algorithms. In: Maltarollo VG (ed) Computer-aided and machine learning-driven drug design: from theory to applications. Springer, Cham, pp 163\u2013198. https:\/\/doi.org\/10.1007\/978-3-031-76718-0_7"},{"issue":"2","key":"11525_CR74","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1574-695X.2008.00465.x","volume":"54","author":"SS Laforce-Nesbitt","year":"2008","unstructured":"Laforce-Nesbitt SS, Sullivan MA, Hoyer LL, Bliss JM (2008) Inhibition of Candida albicans adhesion by recombinant human antibody single-chain variable fragment specific for Als3p. FEMS Immunol Med Microbiol 54(2):195\u2013202. https:\/\/doi.org\/10.1111\/j.1574-695X.2008.00465.x","journal-title":"FEMS Immunol Med Microbiol"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11525-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11525-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11525-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:39:02Z","timestamp":1783161542000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-026-11525-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,29]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["11525"],"URL":"https:\/\/doi.org\/10.1007\/s11030-026-11525-2","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,29]]},"assertion":[{"value":"22 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}