{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:17:59Z","timestamp":1792783079521,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation","award":["82460691"],"award-info":[{"award-number":["82460691"]}]},{"name":"the National Natural Science Foundation","award":["32270413"],"award-info":[{"award-number":["32270413"]}]},{"name":"the Science and Technology Department of Guizhou Province","award":["QKHJC-ZK[2023]YB15"],"award-info":[{"award-number":["QKHJC-ZK[2023]YB15"]}]},{"name":"Guizhou Minzu University fund doctoral research start-up fund","award":["GZMUZK[2024]QD45"],"award-info":[{"award-number":["GZMUZK[2024]QD45"]}],"id":[{"id":"https:\/\/ror.org\/00qm4t918","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Yunnan Characteristic Plant Screening and R&D Service CXO Platform","award":["2022YKZY001"],"award-info":[{"award-number":["2022YKZY001"]}]},{"name":"National College Student Innovation and Entrepreneurship Training Program with Project","award":["202510672654"],"award-info":[{"award-number":["202510672654"]}]},{"name":"Guizhou Science and Technology Innovation Talent Team","award":["QKHPTRC-CXTD[2022]007"],"award-info":[{"award-number":["QKHPTRC-CXTD[2022]007"]}]},{"name":"Guizhou Provincial Major Scientific and Technological Program","award":["[2024]015"],"award-info":[{"award-number":["[2024]015"]}]},{"name":"Guizhou Science and Technology Department","award":["CXPTXM[2025]010\/[2025]021\/KXJZ[2025]014"],"award-info":[{"award-number":["CXPTXM[2025]010\/[2025]021\/KXJZ[2025]014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-026-11576-5","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:46:49Z","timestamp":1778330809000},"page":"6847-6862","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyprenylated acylphloroglucinols from Hypericum monogynum and their reversal of multidrug resistance in MCF-7\/ADR cells"],"prefix":"10.1007","volume":"30","author":[{"given":"Yan-Rong","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jin","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Mao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"11576_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","volume":"66","author":"M Arnold","year":"2022","unstructured":"Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S, Soerjomataram I (2022) Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast 66:15\u201323. https:\/\/doi.org\/10.1016\/j.breast.2022.08.010","journal-title":"Breast"},{"key":"11576_CR2","doi-asserted-by":"publisher","first-page":"9605439","DOI":"10.1155\/2022\/9605439","volume":"2022","author":"D Kashyap","year":"2022","unstructured":"Kashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, Zaguia A, Koundal S, Belay A (2022) Global increase in breast cancer incidence: Risk factors and preventive measures. Biomed Res Int 2022:9605439. https:\/\/doi.org\/10.1155\/2022\/9605439","journal-title":"Biomed Res Int"},{"issue":"7","key":"11576_CR3","doi-asserted-by":"publisher","first-page":"3886","DOI":"10.1002\/ptr.7096","volume":"35","author":"G Cheng","year":"2021","unstructured":"Cheng G, Pi Z, Zhuang X, Zheng Z, Liu S, Liu Z, Song F (2021) The effects and mechanisms of aloe-emodin on reversing adriamycin\u2010induced resistance of MCF\u20107\/ADR cells. Phytother Res 35(7):3886\u20133897. https:\/\/doi.org\/10.1002\/ptr.7096","journal-title":"Phytother Res"},{"key":"11576_CR4","doi-asserted-by":"publisher","first-page":"177637","DOI":"10.1016\/j.ejphar.2025.177637","volume":"998","author":"J Guo","year":"2025","unstructured":"Guo J, Liu F, Yang X, Wang M, Yang S, Lan K, Yan L, Cao R, Chen X, Zhong W (2025) TRPM4 channels contribute to Adriamycin chemoresistance in breast cancer cells. Eur J Pharmacol 998:177637. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177637","journal-title":"Eur J Pharmacol"},{"key":"11576_CR5","doi-asserted-by":"publisher","first-page":"105975","DOI":"10.1016\/j.phrs.2021.105975","volume":"175","author":"GEF Abd ellatef","year":"2022","unstructured":"Abd ellatef GEF, Gazzano E, El-Desoky AH, Hamed AR, Kopecka J, Belisario DC, Costamagna CS, Marie MA, Fahmy SR, Abdel-Hamid AHZ, Riganti C (2022) Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein. Pharmacol Res 175:105975. https:\/\/doi.org\/10.1016\/j.phrs.2021.105975","journal-title":"Pharmacol Res"},{"key":"11576_CR6","doi-asserted-by":"publisher","first-page":"101029","DOI":"10.1016\/j.mtbio.2024.101029","volume":"26","author":"S Zhu","year":"2024","unstructured":"Zhu S, Sun C, Cai Z, Li Y, Liu W, Luan Y, Wang C (2024) Effective therapy of advanced breast cancer through synergistic anticancer by paclitaxel and P-glycoprotein inhibitor. Mater Today Bio 26:101029. https:\/\/doi.org\/10.1016\/j.mtbio.2024.101029","journal-title":"Mater Today Bio"},{"key":"11576_CR7","doi-asserted-by":"publisher","first-page":"952980","DOI":"10.3389\/fphar.2022.952980","volume":"13","author":"Z Zeng","year":"2022","unstructured":"Zeng Z, Liao S, Zhou H, Liu H, Lin J, Huang Y, Zhou C, Xu D (2022) Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function. Front Pharmacol 13:952980. https:\/\/doi.org\/10.3389\/fphar.2022.952980","journal-title":"Front Pharmacol"},{"issue":"3","key":"11576_CR8","doi-asserted-by":"publisher","first-page":"9420120","DOI":"10.26599\/FMH.2025.9420120","volume":"2","author":"MY Li","year":"2025","unstructured":"Li MY, Zhang Q, Li J, Zengin G, (2025) Food and medicine homology in cancer treatment: traditional thoughts collide with scientific evidence. Food & Medicine Homology 2(3):9420120. https:\/\/doi.org\/110.26599\/FMH.2025.9420120","journal-title":"Food & Medicine Homology"},{"key":"11576_CR9","doi-asserted-by":"publisher","first-page":"113054","DOI":"10.1016\/j.biopha.2022.113054","volume":"150","author":"S Hashem","year":"2022","unstructured":"Hashem S, Ali TA, Akhtar S, Nisar S, Sageena G, Ali S, AlMannai S, Therachiyil L, Mir R, Elfaki I, Mir MM, Jamal F, Masoodi T, Uddin S, Singh M, Haris M, Macha M, Bhat AA (2022) Targeting cancer signaling pathways by natural products: exploring promising anti-cancer agents. Biomed Pharmacother 150:113054. https:\/\/doi.org\/10.1016\/j.biopha.2022.113054","journal-title":"Biomed Pharmacother"},{"key":"11576_CR10","doi-asserted-by":"publisher","first-page":"105246","DOI":"10.1016\/j.bioorg.2021.105246","volume":"115","author":"YL Duan","year":"2021","unstructured":"Duan YL, Deng YF, Bu PF, Guo Y, Shi ZY, Cao YY, Zhang YT, Hu H, Qi ZX, Hu CX, Zhang YH (2021) Discovery of bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii. Bioorg Chem 115:105246. https:\/\/doi.org\/10.1016\/j.bioorg.2021.105246","journal-title":"Bioorg Chem"},{"key":"11576_CR11","doi-asserted-by":"publisher","first-page":"107864","DOI":"10.1016\/j.bioorg.2024.107864","volume":"153","author":"XY Hu","year":"2024","unstructured":"Hu XY, Luo HJ, Wei X, Wang YZ, Ye YS, Wan SJ, Zheng D, Zhou Y, Xu HX, Li XR, Lin LG, Xu G (2024) Anti-inflammatory bicyclic polyprenylated acylphloroglucinols with diverse architectures including an unprecedented 6\/6\/6 tricyclic core from Garcinia yunnanensis. Bioorg Chem 153:107864. https:\/\/doi.org\/10.1016\/j.bioorg.2024.107864","journal-title":"Bioorg Chem"},{"issue":"13","key":"11576_CR12","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1021\/acs.orglett.5c00605","volume":"27","author":"Q Lin","year":"2025","unstructured":"Lin Q, Xie HY, Tang Q, Zhang HS, Cheng MJ, Zhan ZC, Wang HY, Li YL, Wang H, Wang GC, Zhang YB (2025) Garcioblons A\u2013F, polycyclic polyprenylated acylphloroglucinols with diverse rearranged skeletons from Garcinia oblongifolia. Org Lett 27(13):3273\u20133278. https:\/\/doi.org\/10.1021\/acs.orglett.5c00605","journal-title":"Org Lett"},{"issue":"19","key":"11576_CR13","doi-asserted-by":"publisher","first-page":"5350","DOI":"10.1039\/D4QO01010H","volume":"11","author":"J Wei","year":"2024","unstructured":"Wei J, Fan PX, Li X, Li Z, Chen X, Zeng H, Wu Z, Zhang Y, Hu Z (2024) Unprecedented nor-seco-polycyclic polyprenylated acylphloroglucinols counteract myocardial cell injury via activation of the Akt\/mTOR signaling pathway. Org Chem Front 11(19):5350\u20135357. https:\/\/doi.org\/10.1039\/D4QO01010H","journal-title":"Org Chem Front"},{"issue":"2","key":"11576_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1039\/c6qo00620e","volume":"4","author":"WJ Xu","year":"2017","unstructured":"Xu WJ, Luo J, Li RJ, Yang MH, Kong LY (2017) Furanmonogones A and B: two rearranged acylphloroglucinols with a 4 5-seco-3 (2 H)-furanone core from the flowers of Hypericum monogynum. Org Chem Front 4(2):313\u2013317. https:\/\/doi.org\/10.1039\/c6qo00620e","journal-title":"Org Chem Front"},{"key":"11576_CR15","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2025.2567636","author":"S Zhou","year":"2025","unstructured":"Zhou S, Du J (2025) (\u00b1)-Harmansenoids A and B, two pairs of new phloroglucinols with cardioprotective effects from Hypericum monogynum L. (Hypericaceae). Nat Prod Res. https:\/\/doi.org\/10.1080\/14786419.2025.2567636","journal-title":"Nat Prod Res"},{"issue":"9","key":"11576_CR16","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1002\/cjoc.202100210","volume":"39","author":"YR Zeng","year":"2021","unstructured":"Zeng YR, Li YN, Yang J, Yi P, Huang L, Huang LJ, Gu W, Hu ZX, Li YM, Yuan CM, Hao XJ (2021) Hypermonones A-I new polyprenylated acylphloroglucinols from Hypericum monogynum with multidrug resistance reversal activity. Chin J Chem 39(9):2422\u20132432. https:\/\/doi.org\/10.1002\/cjoc.202100210","journal-title":"Chin J Chem"},{"issue":"7","key":"11576_CR17","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1080\/10286020.2024.2441773","volume":"27","author":"YK Zhang","year":"2025","unstructured":"Zhang YK, Zhan X, Jian-Bo T, Jing T, Min Y, Zeng YR, Tan CJ (2025) Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate. J Asian Nat Prod Res 27(7):1058\u20131071. https:\/\/doi.org\/10.1080\/10286020.2024.2441773","journal-title":"J Asian Nat Prod Res"},{"key":"11576_CR18","doi-asserted-by":"publisher","first-page":"103428","DOI":"10.1016\/j.bioorg.2019.103428","volume":"94","author":"J Vaijanathappa","year":"2020","unstructured":"Vaijanathappa J, Puttaswamygowda J, Bevanhalli R, Dixit S, Prabhakaran P (2020) Molecular docking, antiproliferative and anticonvulsant activities of swertiamarin isolated from Enicostemma axillare. Bioorg Chem 94:103428. https:\/\/doi.org\/10.1016\/j.bioorg.2019.103428","journal-title":"Bioorg Chem"},{"issue":"1","key":"11576_CR19","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1080\/14756366.2022.2036137","volume":"37","author":"MF Said","year":"2022","unstructured":"Said MF, George RF, Petreni A, Supuran CT, Mohamed NM (2022) Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. J Enzym Inhib Med Ch 37(1):701\u2013717. https:\/\/doi.org\/10.1080\/14756366.2022.2036137","journal-title":"J Enzym Inhib Med Ch"},{"issue":"12","key":"11576_CR20","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/j.tetlet.2012.01.052","volume":"53","author":"N Tanaka","year":"2012","unstructured":"Tanaka N, Abe S, Kobayashi JI (2012) Biyoulactones D and E meroterpenoids from Hypericum chinense. Tetrahedron Lett 53(12):1507\u20131510. https:\/\/doi.org\/10.1016\/j.tetlet.2012.01.052","journal-title":"Tetrahedron Lett"},{"key":"11576_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.bioorg.2019.03.025","volume":"87","author":"YY Liu","year":"2019","unstructured":"Liu YY, Ao Z, Xu QQ, Zhu DR, Chen C, Wang XB, Luo JG, Kong LY (2019) Hyperpatulols A\u2013I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum. Bioorg Chem 87:409\u2013416. https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.025","journal-title":"Bioorg Chem"},{"issue":"8","key":"11576_CR22","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.fitote.2012.08.022","volume":"83","author":"WB Xin","year":"2012","unstructured":"Xin WB, Man XH, Zheng CJ, Jia M, Jiang YP, Zhao XX, Jin GL, Mao ZJ, Huang HQ, Qin LP (2012) Prenylated phloroglucinol derivatives from Hypericum sampsonii. Fitoterapia 83(8):1540\u20131547. https:\/\/doi.org\/10.1016\/j.fitote.2012.08.022","journal-title":"Fitoterapia"},{"issue":"46","key":"11576_CR23","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1016\/j.tetlet.2018.09.071","volume":"59","author":"YT Duan","year":"2017","unstructured":"Duan YT, Zhang J, Lao YZ, Tan HS, Ye YS, Yang XW, Xu HX, Xu G (2017) Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi. Tetrahedron Lett 59(46):4067\u20134072. https:\/\/doi.org\/10.1016\/j.tetlet.2018.09.071","journal-title":"Tetrahedron Lett"},{"issue":"8","key":"11576_CR24","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1021\/np900109y","volume":"72","author":"N Tanaka","year":"2009","unstructured":"Tanaka N, Kashiwada Y, Kim SY, Hashida W, Sekiya M, Ikeshiro Y, Takaishi Y (2009) Acylphloroglucinol biyouyanagiol biyouyanagin B and related Spiro-lactones from Hypericum chinense. J Nat Prod 72(8):1447\u20131452. https:\/\/doi.org\/10.1021\/np900109y","journal-title":"J Nat Prod"},{"issue":"10","key":"11576_CR25","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1021\/np400984c","volume":"77","author":"GP Yin","year":"2014","unstructured":"Yin GP, Li LC, Zhang QZ, An YW, Zhu JJ, Wang ZM, Chou GX, Wang ZT (2014) iNOS inhibitory activity of sesquiterpenoids and a monoterpenoid from the rhizomes of Curcuma wenyu. J Nat Prod 77(10):2161\u20132169. https:\/\/doi.org\/10.1021\/np400984c","journal-title":"J Nat Prod"},{"issue":"7","key":"11576_CR26","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1177\/1934578x1400900720","volume":"9","author":"R Force","year":"2014","unstructured":"Force R, Chen SL, Fortier E, Rowlands E, Heneks J, Rovnyak D, Henry GE (2014) Spirocyclic acylphloroglucinol derivatives from Hypericum pyramidatum. Nat Prod Commun 9(7):961\u2013964. https:\/\/doi.org\/10.1177\/1934578x1400900720","journal-title":"Nat Prod Commun"},{"issue":"20","key":"11576_CR27","doi-asserted-by":"publisher","first-page":"7926","DOI":"10.1021\/acs.orglett.0c02853","volume":"22","author":"N Zhang","year":"2020","unstructured":"Zhang N, Shi ZY, Xu QQ, Sun WG, Gu LH, Xe SS, Go Y, Duan YY, Zhang KY, Qi CX, Zhang YH (2020) Longisglucinols A\u2013C structurally intriguing polycyclic polyprenylated acylphloroglucinols with anti-inflammatory activity from Hypericum longistylum. Org Lett 22(20):7926\u20137929. https:\/\/doi.org\/10.1021\/acs.orglett.0c02853","journal-title":"Org Lett"},{"key":"11576_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00204-023-03618-w","volume":"98","author":"L Phondeth","year":"2024","unstructured":"Phondeth L, Kamaraj R, Nilles J, Weiss J, Haefeli1 WE, P\u00e1vek P, Theile D (2024) Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site. Arch Toxicol 98:223\u2013231. https:\/\/doi.org\/10.1007\/s00204-023-03618-w","journal-title":"Arch Toxicol"},{"issue":"6","key":"11576_CR29","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1016\/j.apsb.2024.02.002","volume":"14","author":"Y Duan","year":"2024","unstructured":"Duan Y, Sun W, Li Y, Shi Z, Li L, Zhang Y, Huang K, Zhang Z, Qi C, Zhang Y (2024) Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-\u03b1 inhibitors with unprecedented chemical architectures. Acta Pharm Sin B 14(6):2646\u20132656. https:\/\/doi.org\/10.1016\/j.apsb.2024.02.002","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"11576_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s12272-024-01526-w","volume":"48","author":"W Ma","year":"2025","unstructured":"Ma W, Ren FC, Wang XR, Li N (2025) Three new xanthones and other anti-inflammatory components from the aerial parts of Hypericum beanii. Arch Pharm Res 48(1):89\u2013101. https:\/\/doi.org\/10.1007\/s12272-024-01526-w","journal-title":"Arch Pharm Res"},{"key":"11576_CR31","unstructured":"Editorial Committee of Flora of China (1990) Chinese Academy of Sciences. Flora of China 50 (2), Science Press, Beijing, pp. 36\u201337. Accessed 09 Sept 2024. https:\/\/www.iplant.cn\/info\/Hypericum% 20bea nii?t\u2009=\u2009foc."},{"key":"11576_CR32","doi-asserted-by":"publisher","first-page":"155847","DOI":"10.1016\/j.phymed.2024.155847","volume":"132","author":"ZM Jiang","year":"2024","unstructured":"Jiang ZM, Wang FF, Zhao YY, Lu LF, Jiang XY, Huang TQ, Lin Y, Guo L, Weng ZB, Liu EH (2024) Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NF\u03baB-NLRP2-Caspase1-IL1\u03b2 pathway. Phytomedicine 132:155847. https:\/\/doi.org\/10.1016\/j.phymed.2024.155847","journal-title":"Phytomedicine"},{"issue":"2","key":"11576_CR33","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ptr.8063","volume":"38","author":"A Bouron","year":"2024","unstructured":"Bouron A (2024) Cellular neurobiology of hyperforin. Phytother Res 38(2):636\u2013645. https:\/\/doi.org\/10.1002\/ptr.8063","journal-title":"Phytother Res"},{"issue":"9","key":"11576_CR34","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.lfs.2004.04.005","volume":"75","author":"T Mennini","year":"2004","unstructured":"Mennini T, Gobbi M (2004) The antidepressant mechanism of Hypericum perforatum. Life Sci 75(9):1021\u20131027. https:\/\/doi.org\/10.1016\/j.lfs.2004.04.005","journal-title":"Life Sci"},{"issue":"24","key":"11576_CR35","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1002\/cjoc.202400739","volume":"42","author":"HY Lou","year":"2024","unstructured":"Lou HY, Chen MJ, Yi P, Jin J, Zeng YR, Gu W, Hu ZX, Yang J, Hao XJ, Yuan CM (2024) Hyperkouytones A\u2013O new polyprenylated acylphloroglucinols from Hypericum kouytchense with multidrug resistance reversal activity. Chin J Chem 42(24):3293\u20133307. https:\/\/doi.org\/10.1002\/cjoc.202400739","journal-title":"Chin J Chem"},{"issue":"3","key":"11576_CR36","doi-asserted-by":"publisher","first-page":"109859","DOI":"10.1016\/j.cclet.2024.109859","volume":"36","author":"CM Yuan","year":"2025","unstructured":"Yuan CM, Zeng YR, Huang L, Mou Y, Jin J, Yi P, Li YM, Hao XJ (2025) Hymoins A\u2013C three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum. Chin Chem Lett 36(3):109859. https:\/\/doi.org\/10.1016\/j.cclet.2024.109859","journal-title":"Chin Chem Lett"},{"issue":"7","key":"11576_CR37","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1021\/acs.chemrev.7b00551","volume":"118","author":"XW Yang","year":"2018","unstructured":"Yang XW, Grossman RB, Xu G (2018) Research progress of polycyclic polyprenylated acylphloroglucinols. Chem Rev 118(7):3508\u20133558. https:\/\/doi.org\/10.1021\/acs.chemrev.7b00551","journal-title":"Chem Rev"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11576-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11576-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11576-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:02:51Z","timestamp":1791266571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-026-11576-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["11576"],"URL":"https:\/\/doi.org\/10.1007\/s11030-026-11576-5","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}