{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:27:59Z","timestamp":1793816879541,"version":"4.6.1"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-026-11584-5","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:15:20Z","timestamp":1778566520000},"page":"8611-8641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating network toxicology with multi-omics approaches to elucidate molecular targets and pathway mechanisms in BPA-induced hepatocellular carcinoma"],"prefix":"10.1007","volume":"30","author":[{"given":"Fuling","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"issue":"6","key":"11584_CR1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41419-024-06841-0","volume":"15","author":"O Olarewaju","year":"2024","unstructured":"Olarewaju O, Hu Y, Tsay HC et al (2024) Microrna miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma. Cell Death Dis 15(6):456. https:\/\/doi.org\/10.1038\/s41419-024-06841-0","journal-title":"Cell Death Dis"},{"key":"11584_CR2","doi-asserted-by":"publisher","first-page":"112473","DOI":"10.1016\/j.mce.2025.112473","volume":"599","author":"Z Dong","year":"2025","unstructured":"Dong Z, He L, Wu J et al (2025) Bisphenol A-induced cancer-associated adipocytes promotes breast carcinogenesis via CXCL12\/AKT signaling. Mol Cell Endocrinol 599:112473. https:\/\/doi.org\/10.1016\/j.mce.2025.112473","journal-title":"Mol Cell Endocrinol"},{"key":"11584_CR3","doi-asserted-by":"publisher","first-page":"118209","DOI":"10.1016\/j.ecoenv.2025.118209","volume":"296","author":"X Zhou","year":"2025","unstructured":"Zhou X, Wei C, Liu X et al (2025) Revealing the role of bisphenol A on prostate cancer progression and identifying potential targets: a comprehensive analysis from population cohort to molecular mechanism. Ecotoxicol Environ Saf 296:118209. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118209","journal-title":"Ecotoxicol Environ Saf"},{"issue":"9","key":"11584_CR4","doi-asserted-by":"publisher","first-page":"e3723","DOI":"10.1002\/jgm.3723","volume":"26","author":"Q Liu","year":"2024","unstructured":"Liu Q, Niu R, Ye Y et al (2024) Exploring the interplay between bisphenol A exposure, the immune microenvironment and hepatocellular carcinoma progression. J Gene Med 26(9):e3723. https:\/\/doi.org\/10.1002\/jgm.3723","journal-title":"J Gene Med"},{"key":"11584_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.fct.2017.11.010","volume":"111","author":"S Kim","year":"2018","unstructured":"Kim S, Mun GI, Choi E et al (2018) Submicromolar bisphenol A induces proliferation and DNA damage in human hepatocyte cell lines in vitro and in juvenile rats in vivo. Food Chem Toxicol 111:125\u2013132. https:\/\/doi.org\/10.1016\/j.fct.2017.11.010","journal-title":"Food Chem Toxicol"},{"issue":"10","key":"11584_CR6","doi-asserted-by":"publisher","first-page":"101548","DOI":"10.1016\/j.isci.2020.101548","volume":"23","author":"T Kato","year":"2020","unstructured":"Kato T, Yamada T, Nakamura H et al (2020) The loss of nuclear PTEN increases tumorigenesis in a preclinical mouse model for hepatocellular carcinoma. iScience 23(10):101548. https:\/\/doi.org\/10.1016\/j.isci.2020.101548","journal-title":"iScience"},{"key":"11584_CR7","doi-asserted-by":"publisher","first-page":"111314","DOI":"10.1016\/j.fct.2020.111314","volume":"141","author":"SK Anand","year":"2020","unstructured":"Anand SK, Sharma A, Singh N et al (2020) Activation of autophagic flux via LKB1\/AMPK\/mTOR axis against xenoestrogen bisphenol A exposure in primary rat hepatocytes. Food Chem Toxicol 141:111314. https:\/\/doi.org\/10.1016\/j.fct.2020.111314","journal-title":"Food Chem Toxicol"},{"key":"11584_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.envres.2019.03.035","volume":"173","author":"BY Kim","year":"2019","unstructured":"Kim BY, Kim M, Jeong JS et al (2019) Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res 173:124\u2013134. https:\/\/doi.org\/10.1016\/j.envres.2019.03.035","journal-title":"Environ Res"},{"issue":"4","key":"11584_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12032-017-0914-5","volume":"34","author":"C Ma-on","year":"2017","unstructured":"Ma-on C, Sanpavat A, Whongsiri P et al (2017) Oxidative stress indicated by elevated expression of Nrf2 and 8-OHdG promotes hepatocellular carcinoma progression. Med Oncol 34(4):57. https:\/\/doi.org\/10.1007\/s12032-017-0914-5","journal-title":"Med Oncol"},{"issue":"11","key":"11584_CR10","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1530\/erc-21-0198","volume":"28","author":"TFR Ruiz","year":"2021","unstructured":"Ruiz TFR, Colleta SJ, Leonel ECR et al (2021) Mammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactation. Endocr Relat Cancer 28(11):715\u2013730. https:\/\/doi.org\/10.1530\/erc-21-0198","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"11584_CR11","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.1038\/s41598-017-10135-1","volume":"7","author":"MI Palacios-Arreola","year":"2017","unstructured":"Palacios-Arreola MI, Nava-Castro KE, R\u00edo-Araiza VHD et al (2017) A single neonatal administration of bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood. Sci Rep 7(1):10573. https:\/\/doi.org\/10.1038\/s41598-017-10135-1","journal-title":"Sci Rep"},{"key":"11584_CR12","doi-asserted-by":"publisher","first-page":"134681","DOI":"10.1016\/j.scitotenv.2019.134681","volume":"703","author":"H Ji","year":"2020","unstructured":"Ji H, Song N, Ren J et al (2020) Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice. Sci Total Environ 703:134681. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134681","journal-title":"Sci Total Environ"},{"key":"11584_CR13","doi-asserted-by":"publisher","first-page":"118906","DOI":"10.1016\/j.ecoenv.2025.118906","volume":"303","author":"Y Gui","year":"2025","unstructured":"Gui Y, Li C, Wang W et al (2025) Bisphenol A induces cellular senescence in SW1353 chondrocytes via miRNA-449a-mediated downregulation of SIRT1. Ecotoxicol Environ Saf 303:118906. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118906","journal-title":"Ecotoxicol Environ Saf"},{"key":"11584_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.canlet.2019.05.036","volume":"459","author":"L Fang","year":"2019","unstructured":"Fang L, Du WW, Awan FM et al (2019) The circular RNA circ-Ccnb1 dissociates Ccnb1\/Cdk1 complex suppressing cell invasion and tumorigenesis. Cancer Lett 459:216\u2013226. https:\/\/doi.org\/10.1016\/j.canlet.2019.05.036","journal-title":"Cancer Lett"},{"issue":"1","key":"11584_CR15","doi-asserted-by":"publisher","first-page":"21396","DOI":"10.1038\/s41598-021-00889-0","volume":"11","author":"Y Kusakabe","year":"2021","unstructured":"Kusakabe Y, Chiba T, Oshima M et al (2021) EZH1\/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma. Sci Rep 11(1):21396. https:\/\/doi.org\/10.1038\/s41598-021-00889-0","journal-title":"Sci Rep"},{"issue":"1","key":"11584_CR16","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s12876-021-01984-2","volume":"21","author":"SY Wu","year":"2021","unstructured":"Wu SY, Liao P, Yan LY et al (2021) Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma. BMC Gastroenterol 21(1):416. https:\/\/doi.org\/10.1186\/s12876-021-01984-2","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"11584_CR17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s10142-025-01615-z","volume":"25","author":"AM Ayoub","year":"2025","unstructured":"Ayoub AM, Mahmoud EA, Mohamed RH et al (2025) BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potential. Funct Integr Genomics 25(1):120. https:\/\/doi.org\/10.1007\/s10142-025-01615-z","journal-title":"Funct Integr Genomics"},{"key":"11584_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020413","author":"W M\u0105czka","year":"2022","unstructured":"M\u0105czka W, Grabarczyk M, Wi\u0144ska K (2022) Can antioxidants reduce the toxicity of bisphenol? Antioxid (Basel). https:\/\/doi.org\/10.3390\/antiox11020413","journal-title":"Antioxid (Basel)"},{"key":"11584_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.talanta.2018.02.037","volume":"182","author":"H Zhao","year":"2018","unstructured":"Zhao H, Wei J, Xiang L et al (2018) Mass spectrometry investigation of DNA adduct formation from bisphenol A quinone metabolite and MCF-7 cell DNA. Talanta 182:583\u2013589. https:\/\/doi.org\/10.1016\/j.talanta.2018.02.037","journal-title":"Talanta"},{"issue":"1","key":"11584_CR20","doi-asserted-by":"publisher","first-page":"7481","DOI":"10.1038\/s41598-017-07850-0","volume":"7","author":"H Rajabi","year":"2017","unstructured":"Rajabi H, Hiraki M, Tagde A et al (2017) MUC1-C activates EZH2 expression and function in human cancer cells. Sci Rep 7(1):7481. https:\/\/doi.org\/10.1038\/s41598-017-07850-0","journal-title":"Sci Rep"},{"issue":"1","key":"11584_CR21","doi-asserted-by":"publisher","first-page":"e13144","DOI":"10.1111\/aji.13144","volume":"82","author":"X Li","year":"2019","unstructured":"Li X, Ma XL, Tian FJ et al (2019) Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. Am J Reprod Immunol 82(1):e13144. https:\/\/doi.org\/10.1111\/aji.13144","journal-title":"Am J Reprod Immunol"},{"key":"11584_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062578","author":"N Bao","year":"2025","unstructured":"Bao N, Chen Z, Li B et al (2025) Study on the mechanism of formononetin against hepatocellular carcinoma: regulating metabolic pathways of ferroptosis and cell cycle. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26062578","journal-title":"Int J Mol Sci"},{"key":"11584_CR23","doi-asserted-by":"publisher","first-page":"828684","DOI":"10.3389\/fonc.2022.828684","volume":"12","author":"AB Bukhari","year":"2022","unstructured":"Bukhari AB, Chan GK, Gamper AM (2022) Targeting the DNA damage response for cancer therapy by inhibiting the kinase Wee1. Front Oncol 12:828684. https:\/\/doi.org\/10.3389\/fonc.2022.828684","journal-title":"Front Oncol"},{"issue":"11","key":"11584_CR24","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1097\/dcr.0000000000002734","volume":"66","author":"J Lv","year":"2023","unstructured":"Lv J, Li W, Wang X et al (2023) Identification of MKI67, TPR, and TCHH mutations as prognostic biomarkers for patients with defective mismatch repair colon cancer stage II\/III. Dis Colon Rectum 66(11):1481\u20131491. https:\/\/doi.org\/10.1097\/dcr.0000000000002734","journal-title":"Dis Colon Rectum"},{"key":"11584_CR25","doi-asserted-by":"publisher","first-page":"105640","DOI":"10.1016\/j.jsbmb.2020.105640","volume":"200","author":"Y Xiong","year":"2020","unstructured":"Xiong Y, Wen X, Liu H et al (2020) Bisphenol A affects endometrial stromal cells decidualization, involvement of epigenetic regulation. J Steroid Biochem Mol Biol 200:105640. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105640","journal-title":"J Steroid Biochem Mol Biol"},{"key":"11584_CR26","doi-asserted-by":"publisher","first-page":"102945","DOI":"10.1016\/j.tice.2025.102945","volume":"96","author":"M Gao","year":"2025","unstructured":"Gao M, Xing C (2025) Mechanism of EZH2-mediated histone methylation promoting bFGF-induced angiogenesis of human umbilical vein endothelial cells. Tissue Cell 96:102945. https:\/\/doi.org\/10.1016\/j.tice.2025.102945","journal-title":"Tissue Cell"},{"issue":"3","key":"11584_CR27","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/tox.22282","volume":"32","author":"C Wang","year":"2017","unstructured":"Wang C, Qi S, Liu C et al (2017) Mitochondrial dysfunction and Ca(2+) overload in injured Sertoli cells exposed to bisphenol A. Environ Toxicol 32(3):823\u2013831. https:\/\/doi.org\/10.1002\/tox.22282","journal-title":"Environ Toxicol"},{"issue":"3","key":"11584_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.18502\/ijrm.v22i3.16166","volume":"22","author":"L Khorsandi","year":"2023","unstructured":"Khorsandi L, Heidari-Moghaddam A, Younesi E et al (2023) Naringenin ameliorates cytotoxic effects of bisphenol A on mouse Sertoli cells by suppressing oxidative stress and modulating mitophagy: an experimental study. Int J Reprod Biomed 22(3):219\u2013228. https:\/\/doi.org\/10.18502\/ijrm.v22i3.16166","journal-title":"Int J Reprod Biomed"},{"issue":"4","key":"11584_CR29","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1080\/15548627.2021.1898750","volume":"17","author":"Z Li","year":"2021","unstructured":"Li Z, Zhang X (2021) Phospho-regulation and function of ULK1-ATG13 during the cell cycle. Autophagy 17(4):1054\u20131056. https:\/\/doi.org\/10.1080\/15548627.2021.1898750","journal-title":"Autophagy"},{"issue":"6","key":"11584_CR30","doi-asserted-by":"publisher","first-page":"e3000718","DOI":"10.1371\/journal.pbio.3000718","volume":"18","author":"A Yamasaki","year":"2020","unstructured":"Yamasaki A, Jin Y, Ohsumi Y (2020) Mitotic phosphorylation of the ULK complex regulates cell cycle progression. PLoS Biol 18(6):e3000718. https:\/\/doi.org\/10.1371\/journal.pbio.3000718","journal-title":"PLoS Biol"},{"key":"11584_CR31","doi-asserted-by":"publisher","first-page":"172655","DOI":"10.1016\/j.scitotenv.2024.172655","volume":"929","author":"L Meng","year":"2024","unstructured":"Meng L, Ouyang Z, Chen Y et al (2024) Low-dose BPA-induced neuronal energy metabolism dysfunction and apoptosis mediated by PINK1\/parkin mitophagy pathway in juvenile rats. Sci Total Environ 929:172655. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.172655","journal-title":"Sci Total Environ"},{"issue":"9","key":"11584_CR32","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1210\/en.2016-1479","volume":"158","author":"S Yang","year":"2017","unstructured":"Yang S, Zhang A, Li T et al (2017) Dysregulated autophagy in hepatocytes promotes bisphenol A-induced hepatic lipid accumulation in male mice. Endocrinology 158(9):2799\u20132812. https:\/\/doi.org\/10.1210\/en.2016-1479","journal-title":"Endocrinology"},{"key":"11584_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23","author":"MI Palacios-Arreola","year":"2022","unstructured":"Palacios-Arreola MI, Moreno-Mendoza NA, Nava-Castro KE et al (2022) The endocrine disruptor compound bisphenol A (BPA) regulates the intra-tumoral immune microenvironment and increases lung metastasis in an experimental model of breast cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23","journal-title":"Int J Mol Sci"},{"key":"11584_CR34","doi-asserted-by":"publisher","first-page":"114579","DOI":"10.1016\/j.intimp.2025.114579","volume":"155","author":"J Liu","year":"2025","unstructured":"Liu J, Su Y, Zhang C et al (2025) NCOA3 impairs the efficacy of anti-PD-L1 therapy via HSP90\u03b1\/EZH2\/CXCL9 axis in colon cancer. Int Immunopharmacol 155:114579. https:\/\/doi.org\/10.1016\/j.intimp.2025.114579","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"11584_CR35","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.jid.2017.10.036","volume":"138","author":"S Yi","year":"2018","unstructured":"Yi S, Sun J, Qiu L et al (2018) Dual role of EZH2 in cutaneous anaplastic large cell lymphoma: promoting tumor cell survival and regulating tumor microenvironment. J Invest Dermatol 138(5):1126\u20131136. https:\/\/doi.org\/10.1016\/j.jid.2017.10.036","journal-title":"J Invest Dermatol"},{"issue":"3","key":"11584_CR36","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.3892\/ol.2018.8986","volume":"16","author":"X Shang","year":"2018","unstructured":"Shang X, Liu G, Zhang Y et al (2018) Downregulation of BIRC5 inhibits the migration and invasion of esophageal cancer cells by interacting with the PI3K\/Akt signaling pathway. Oncol Lett 16(3):3373\u20133379. https:\/\/doi.org\/10.3892\/ol.2018.8986","journal-title":"Oncol Lett"},{"issue":"8","key":"11584_CR37","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.21037\/jtd-2025-216","volume":"17","author":"S Yang","year":"2025","unstructured":"Yang S, Liu X, Mao S et al (2025) BIRC5 expression correlates with immunosuppressive phenotype and predicts inferior response to immunotherapy in lung adenocarcinoma. J Thorac Dis 17(8):5921\u20135935. https:\/\/doi.org\/10.21037\/jtd-2025-216","journal-title":"J Thorac Dis"},{"key":"11584_CR38","doi-asserted-by":"publisher","first-page":"124706","DOI":"10.1016\/j.ijpharm.2024.124706","volume":"665","author":"N Pang","year":"2024","unstructured":"Pang N, Yang Z, Zhang W et al (2024) Cancer-associated fibroblasts barrier breaking via TGF-\u03b2 blockade paved way for docetaxel micelles delivery to treat pancreatic cancer. Int J Pharm 665:124706. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124706","journal-title":"Int J Pharm"},{"key":"11584_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ph18050666","author":"L Chen","year":"2025","unstructured":"Chen L, Liao W, Huang J et al (2025) Natural killer cell activation signature identifies cyclin B1\/CDK1 as a druggable target to overcome natural killer cell dysfunction and tumor invasiveness in melanoma. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph18050666","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"11584_CR40","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12079-023-00767-6","volume":"17","author":"Z Qin","year":"2023","unstructured":"Qin Z, He T, Guo C et al (2023) CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix. J Cell Commun Signal 17(2):287\u2013296. https:\/\/doi.org\/10.1007\/s12079-023-00767-6","journal-title":"J Cell Commun Signal"},{"key":"11584_CR41","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-25-2026","author":"M Kastinen","year":"2025","unstructured":"Kastinen M, H\u00e4rk\u00f6nen J, Sirni\u00f6 P et al (2025) Unraveling the effects and characteristics of proliferating tumor and cytotoxic T cells in colorectal cancer. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-25-2026","journal-title":"Clin Cancer Res"},{"key":"11584_CR42","doi-asserted-by":"publisher","first-page":"618966","DOI":"10.3389\/fgene.2020.618966","volume":"11","author":"T Qin","year":"2020","unstructured":"Qin T, Zhang X, Guo T et al (2020) Epigenetic alteration shaped by the environmental chemical bisphenol A. Front Genet 11:618966. https:\/\/doi.org\/10.3389\/fgene.2020.618966","journal-title":"Front Genet"},{"key":"11584_CR43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejphar.2017.09.023","volume":"815","author":"Q Li","year":"2017","unstructured":"Li Q, Li B, Dong C et al (2017) 20(S)-ginsenoside Rh2 suppresses proliferation and migration of hepatocellular carcinoma cells by targeting EZH2 to regulate CDKN2A-2B gene cluster transcription. Eur J Pharmacol 815:173\u2013180. https:\/\/doi.org\/10.1016\/j.ejphar.2017.09.023","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"11584_CR44","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12032-023-02025-6","volume":"40","author":"Y Liu","year":"2023","unstructured":"Liu Y, Yang Q (2023) The roles of EZH2 in cancer and its inhibitors. Med Oncol 40(6):167. https:\/\/doi.org\/10.1007\/s12032-023-02025-6","journal-title":"Med Oncol"},{"issue":"8","key":"11584_CR45","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.7150\/ijbs.93201","volume":"20","author":"J Zhang","year":"2024","unstructured":"Zhang J, Duan B, Li F et al (2024) SETD7 promotes cell proliferation and migration via methylation-mediated TAF7 in clear cell renal cell carcinoma. Int J Biol Sci 20(8):3008\u20133027. https:\/\/doi.org\/10.7150\/ijbs.93201","journal-title":"Int J Biol Sci"},{"issue":"9","key":"11584_CR46","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1111\/cas.70122","volume":"116","author":"W Yang","year":"2025","unstructured":"Yang W, Wu X, Cai F et al (2025) NFATc4 promotes lung adenocarcinoma progression via the CCNB1\/CDK1 pathway and is a potential prognostic biomarker. Cancer Sci 116(9):2400\u20132412. https:\/\/doi.org\/10.1111\/cas.70122","journal-title":"Cancer Sci"},{"issue":"1","key":"11584_CR47","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s13148-022-01408-2","volume":"14","author":"SC D\u2019Cruz","year":"2022","unstructured":"D\u2019Cruz SC, Hao C, Labussiere M et al (2022) Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data. Clin Epigenetics 14(1):186. https:\/\/doi.org\/10.1186\/s13148-022-01408-2","journal-title":"Clin Epigenetics"},{"issue":"1","key":"11584_CR48","doi-asserted-by":"publisher","first-page":"201123","DOI":"10.1016\/j.omton.2025.201123","volume":"34","author":"M Santhanam","year":"2026","unstructured":"Santhanam M, Babu V, Shteinfer-Kuzmine A et al (2026) Survivin\/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects. Mol Ther Oncol 34(1):201123. https:\/\/doi.org\/10.1016\/j.omton.2025.201123","journal-title":"Mol Ther Oncol"},{"key":"11584_CR49","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.semcdb.2020.04.021","volume":"107","author":"NJ Tatum","year":"2020","unstructured":"Tatum NJ, Endicott JA (2020) Chatterboxes: the structural and functional diversity of cyclins. Semin Cell Dev Biol 107:4\u201320. https:\/\/doi.org\/10.1016\/j.semcdb.2020.04.021","journal-title":"Semin Cell Dev Biol"},{"issue":"12","key":"11584_CR50","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1038\/s41375-020-0816-y","volume":"34","author":"A Chase","year":"2020","unstructured":"Chase A, Score J, Lin F et al (2020) Mutational mechanisms of EZH2 inactivation in myeloid neoplasms. Leukemia 34(12):3206\u20133214. https:\/\/doi.org\/10.1038\/s41375-020-0816-y","journal-title":"Leukemia"},{"key":"11584_CR51","doi-asserted-by":"publisher","first-page":"770939","DOI":"10.3389\/fcell.2021.770939","volume":"9","author":"X Ma","year":"2021","unstructured":"Ma X, \u00d8vreb\u00f8 JI, Thompson EM (2021) Evolution of CDK1 paralog specializations in a lineage with fast developing planktonic embryos. Front Cell Dev Biol 9:770939. https:\/\/doi.org\/10.3389\/fcell.2021.770939","journal-title":"Front Cell Dev Biol"},{"issue":"23","key":"11584_CR52","doi-asserted-by":"publisher","first-page":"9052","DOI":"10.1002\/cam4.3505","volume":"9","author":"Z Gong","year":"2020","unstructured":"Gong Z, Zhang J, Guo W (2020) Tumor purity as a prognosis and immunotherapy relevant feature in gastric cancer. Cancer Med 9(23):9052\u20139063. https:\/\/doi.org\/10.1002\/cam4.3505","journal-title":"Cancer Med"},{"issue":"1","key":"11584_CR53","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1186\/s12885-021-08629-3","volume":"21","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li W, Jin X et al (2021) Identification of prognostic immune-related gene signature associated with tumor microenvironment of colorectal cancer. BMC Cancer 21(1):905. https:\/\/doi.org\/10.1186\/s12885-021-08629-3","journal-title":"BMC Cancer"},{"key":"11584_CR54","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fonc.2020.00333","volume":"10","author":"B Li","year":"2020","unstructured":"Li B, Geng R, Wu Q et al (2020) Alterations in immune-related genes as potential marker of prognosis in breast cancer. Front Oncol 10:333. https:\/\/doi.org\/10.3389\/fonc.2020.00333","journal-title":"Front Oncol"},{"issue":"Pt 2","key":"11584_CR55","doi-asserted-by":"publisher","first-page":"113318","DOI":"10.1016\/j.envpol.2019.113318","volume":"255","author":"E Fatma Karaman","year":"2019","unstructured":"Fatma Karaman E, Caglayan M, Sancar-Bas S et al (2019) Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells. Environ Pollut 255(Pt 2):113318. https:\/\/doi.org\/10.1016\/j.envpol.2019.113318","journal-title":"Environ Pollut"},{"key":"11584_CR56","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tiv.2017.07.028","volume":"44","author":"M Senyildiz","year":"2017","unstructured":"Senyildiz M, Karaman EF, Bas SS et al (2017) Effects of BPA on global DNA methylation and global histone 3 lysine modifications in SH-SY5Y cells: an epigenetic mechanism linking the regulation of chromatin modifying genes. Toxicol Vitro 44:313\u2013321. https:\/\/doi.org\/10.1016\/j.tiv.2017.07.028","journal-title":"Toxicol Vitro"},{"key":"11584_CR57","doi-asserted-by":"publisher","first-page":"111073","DOI":"10.1016\/j.cellsig.2024.111073","volume":"117","author":"F Jiang","year":"2024","unstructured":"Jiang F, Xu Y, Jiang Z et al (2024) Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2. Cell Signal 117:111073. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111073","journal-title":"Cell Signal"},{"issue":"10","key":"11584_CR58","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.3748\/wjg.v24.i10.1152","volume":"24","author":"HW Tsai","year":"2018","unstructured":"Tsai HW, Ho CL, Cheng SW et al (2018) Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma. World J Gastroenterol 24(10):1152\u20131166. https:\/\/doi.org\/10.3748\/wjg.v24.i10.1152","journal-title":"World J Gastroenterol"},{"key":"11584_CR59","doi-asserted-by":"publisher","first-page":"679","DOI":"10.2147\/cmar.S162595","volume":"10","author":"C Yang","year":"2018","unstructured":"Yang C, Su H, Liao X et al (2018) Marker of proliferation Ki-67 expression is associated with transforming growth factor beta 1 and can predict the prognosis of patients with hepatic B virus-related hepatocellular carcinoma. Cancer Manag Res 10:679\u2013696. https:\/\/doi.org\/10.2147\/cmar.S162595","journal-title":"Cancer Manag Res"},{"issue":"1","key":"11584_CR60","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13062-024-00569-9","volume":"19","author":"T Wang","year":"2024","unstructured":"Wang T, Li W, Wu Y et al (2024) Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma. Biol Direct 19(1):128. https:\/\/doi.org\/10.1186\/s13062-024-00569-9","journal-title":"Biol Direct"},{"key":"11584_CR61","doi-asserted-by":"publisher","first-page":"120010","DOI":"10.1016\/j.lfs.2021.120010","volume":"285","author":"TFR Ruiz","year":"2021","unstructured":"Ruiz TFR, Colleta SJ, Zuccari D et al (2021) Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption. Life Sci 285:120010. https:\/\/doi.org\/10.1016\/j.lfs.2021.120010","journal-title":"Life Sci"},{"issue":"14","key":"11584_CR62","doi-asserted-by":"publisher","first-page":"e2105539","DOI":"10.1002\/advs.202105539","volume":"9","author":"L Zhang","year":"2022","unstructured":"Zhang L, Wang L, Hu XB et al (2022) MYPT1\/PP1-mediated EZH2 dephosphorylation at S21 promotes epithelial-mesenchymal transition in fibrosis through control of multiple families of genes. Adv Sci (Weinh) 9(14):e2105539. https:\/\/doi.org\/10.1002\/advs.202105539","journal-title":"Adv Sci (Weinh)"},{"key":"11584_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083816","author":"J Qin","year":"2025","unstructured":"Qin J, Li Z (2025) Identification of CDK1 as a biomarker for the treatment of liver fibrosis and hepatocellular carcinoma through bioinformatics analysis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26083816","journal-title":"Int J Mol Sci"},{"issue":"6","key":"11584_CR64","doi-asserted-by":"publisher","first-page":"e32877","DOI":"10.1097\/md.0000000000032877","volume":"102","author":"C Li","year":"2023","unstructured":"Li C, Gao Y, Lu C et al (2023) Identification of potential biomarkers for colorectal cancer by clinical database analysis and kaplan-meier curves analysis. Med (Baltim) 102(6):e32877. https:\/\/doi.org\/10.1097\/md.0000000000032877","journal-title":"Med (Baltim)"},{"key":"11584_CR65","doi-asserted-by":"publisher","first-page":"963689721100887","DOI":"10.1177\/09636897211008874","volume":"30","author":"M Zhang","year":"2021","unstructured":"Zhang M, Yan X, Wen P et al (2021) CircANKRD52 promotes the tumorigenesis of hepatocellular carcinoma by sponging miR-497-5p and upregulating BIRC5 expression. Cell Transpl 30:9636897211008874. https:\/\/doi.org\/10.1177\/09636897211008874","journal-title":"Cell Transpl"},{"key":"11584_CR66","doi-asserted-by":"publisher","first-page":"110851","DOI":"10.1016\/j.cellsig.2023.110851","volume":"110","author":"J Liao","year":"2023","unstructured":"Liao J, Qing X, Deng G et al (2023) Gastrodin destabilizes survivin and overcomes pemetrexed resistance. Cell Signal 110:110851. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110851","journal-title":"Cell Signal"},{"issue":"1","key":"11584_CR67","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13046-020-01593-z","volume":"39","author":"M Li","year":"2020","unstructured":"Li M, Gao F, Yu X et al (2020) Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma. J Exp Clin Cancer Res 39(1):88. https:\/\/doi.org\/10.1186\/s13046-020-01593-z","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"11584_CR68","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/labinvest.2016.126","volume":"97","author":"SC Bresler","year":"2017","unstructured":"Bresler SC, Min L, Rodig SJ et al (2017) Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity. Lab Invest 97(2):207\u2013216. https:\/\/doi.org\/10.1038\/labinvest.2016.126","journal-title":"Lab Invest"},{"issue":"5","key":"11584_CR69","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41374-018-0182-9","volume":"99","author":"T Nagato","year":"2019","unstructured":"Nagato T, Ueda S, Takahara M et al (2019) Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer\/T-cell lymphoma. Lab Invest 99(5):612\u2013624. https:\/\/doi.org\/10.1038\/s41374-018-0182-9","journal-title":"Lab Invest"},{"issue":"7","key":"11584_CR70","doi-asserted-by":"publisher","first-page":"106976","DOI":"10.1016\/j.isci.2023.106976","volume":"26","author":"M Jensen","year":"2023","unstructured":"Jensen M, Chandrasekaran V, Garc\u00eda-Bonete MJ et al (2023) Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27. iScience 26(7):106976. https:\/\/doi.org\/10.1016\/j.isci.2023.106976","journal-title":"iScience"},{"issue":"3","key":"11584_CR71","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.molcel.2018.03.020","volume":"70","author":"CH Lee","year":"2018","unstructured":"Lee CH, Yu JR, Kumar S et al (2018) Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin. Mol Cell 70(3):422\u2013434. https:\/\/doi.org\/10.1016\/j.molcel.2018.03.020. e6","journal-title":"Mol Cell"},{"issue":"4","key":"11584_CR72","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1021\/acs.jmedchem.5c03100","volume":"69","author":"G Klebe","year":"2026","unstructured":"Klebe G (2026) Thermodynamic data remain a hot tip for decoding binding affinity and water impact on protein-ligand complex formation to assist lead optimization. J Med Chem 69(4):3719\u20133730. https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03100","journal-title":"J Med Chem"},{"key":"11584_CR73","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jmgm.2018.05.001","volume":"83","author":"C Wu","year":"2018","unstructured":"Wu C, Mao L, Huang X et al (2018) Theoretical study of the intermolecular recognition mechanism between survivin and substrate based on conserved binding mode analysis. J Mol Graph Model 83:53\u201363. https:\/\/doi.org\/10.1016\/j.jmgm.2018.05.001","journal-title":"J Mol Graph Model"},{"issue":"24","key":"11584_CR74","doi-asserted-by":"publisher","first-page":"16515","DOI":"10.1021\/acs.jmedchem.3c01130","volume":"66","author":"Q Cui","year":"2023","unstructured":"Cui Q, Huang C, Liu JY et al (2023) Small molecule inhibitors targeting the undruggable survivin: the past, present, and future from a medicinal chemist\u2019s perspective. J Med Chem 66(24):16515\u201316545. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c01130","journal-title":"J Med Chem"},{"key":"11584_CR75","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12935-019-0729-x","volume":"19","author":"J Gu","year":"2019","unstructured":"Gu J, Liu X, Li J et al (2019) MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1. Cancer Cell Int 19:15. https:\/\/doi.org\/10.1186\/s12935-019-0729-x","journal-title":"Cancer Cell Int"},{"key":"11584_CR76","doi-asserted-by":"publisher","first-page":"110662","DOI":"10.1016\/j.cellsig.2023.110662","volume":"107","author":"T Qiu","year":"2023","unstructured":"Qiu T, Ding Y, Qin J et al (2023) Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress. Cell Signal 107:110662. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110662","journal-title":"Cell Signal"},{"key":"11584_CR77","doi-asserted-by":"publisher","first-page":"e925289","DOI":"10.12659\/msm.925289","volume":"26","author":"Y Zou","year":"2020","unstructured":"Zou Y, Ruan S, Jin L et al (2020) CDK1, CCNB1, and CCNB2 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma. Med Sci Monit 26:e925289. https:\/\/doi.org\/10.12659\/msm.925289","journal-title":"Med Sci Monit"},{"issue":"7","key":"11584_CR78","doi-asserted-by":"publisher","first-page":"e2316","DOI":"10.1038\/cddis.2016.198","volume":"7","author":"Y Wang","year":"2016","unstructured":"Wang Y, Sun H, Wang J et al (2016) DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity. Cell Death Dis 7(7):e2316. https:\/\/doi.org\/10.1038\/cddis.2016.198","journal-title":"Cell Death Dis"},{"key":"11584_CR79","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.omto.2022.09.006","volume":"27","author":"H Shinohara","year":"2022","unstructured":"Shinohara H, Sawado R, Nakagawa M et al (2022) Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors. Mol Ther Oncolytics 27:14\u201325. https:\/\/doi.org\/10.1016\/j.omto.2022.09.006","journal-title":"Mol Ther Oncolytics"},{"issue":"48","key":"11584_CR80","doi-asserted-by":"publisher","first-page":"eadl2804","DOI":"10.1126\/sciadv.adl2804","volume":"10","author":"Q Meng","year":"2024","unstructured":"Meng Q, Shen J, Ren Y et al (2024) EZH2 directly methylates PARP1 and regulates its activity in cancer. Sci Adv 10(48):eadl2804. https:\/\/doi.org\/10.1126\/sciadv.adl2804","journal-title":"Sci Adv"},{"issue":"3","key":"11584_CR81","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.3892\/ol.2017.7647","volume":"15","author":"Z Chen","year":"2018","unstructured":"Chen Z, Yang P, Li W et al (2018) Expression of EZH2 is associated with poor outcome in colorectal cancer. Oncol Lett 15(3):2953\u20132961. https:\/\/doi.org\/10.3892\/ol.2017.7647","journal-title":"Oncol Lett"},{"issue":"2","key":"11584_CR82","doi-asserted-by":"publisher","first-page":"114648","DOI":"10.1016\/j.yexcr.2025.114648","volume":"450","author":"A Hjazi","year":"2025","unstructured":"Hjazi A, Hussn A, Kareem AK et al (2025) EZH2 in digestive system cancers: epigenetic regulation, oncogenic interactions, and therapeutic potential. Exp Cell Res 450(2):114648. https:\/\/doi.org\/10.1016\/j.yexcr.2025.114648","journal-title":"Exp Cell Res"},{"key":"11584_CR83","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04528-7","author":"HS Abed","year":"2025","unstructured":"Abed HS, Esanmurodova N, Kumar A et al (2025) Epigenetic regulation of EZH2 by ncRNAs: mechanisms and oncogenic implications. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-04528-7","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"11584_CR84","doi-asserted-by":"publisher","first-page":"574940","DOI":"10.3389\/fcell.2020.574940","volume":"8","author":"B Qi","year":"2020","unstructured":"Qi B, Yang C, Zhu Z et al (2020) EZH2-inhibited microRNA-454-3p promotes M2 macrophage polarization in glioma. Front Cell Dev Biol 8:574940. https:\/\/doi.org\/10.3389\/fcell.2020.574940","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"11584_CR85","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1186\/s12967-025-07071-4","volume":"23","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, Xu Y, Ye M et al (2025) Integrated single-cell RNA-seq analysis reveals that EZH2 regulates the MIF-CD74 axis to modulate T cell activation and exhaustion in hepatocellular carcinoma. J Transl Med 23(1):1040. https:\/\/doi.org\/10.1186\/s12967-025-07071-4","journal-title":"J Transl Med"},{"issue":"1","key":"11584_CR86","doi-asserted-by":"publisher","first-page":"BSR20222230","DOI":"10.1042\/bsr20222230","volume":"43","author":"L Luo","year":"2023","unstructured":"Luo L, Wang Z, Hu T et al (2023) Multiomics characteristics and immunotherapeutic potential of EZH2 in pan-cancer. Biosci Rep 43(1):BSR20222230. https:\/\/doi.org\/10.1042\/bsr20222230","journal-title":"Biosci Rep"},{"key":"11584_CR87","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.2147\/dddt.S508709","volume":"19","author":"RP Li","year":"2025","unstructured":"Li RP, Wu GZ, Fang XD et al (2025) Single-cell transcriptional analysis reveals the mechanism of AZD6738 in HCC immunotherapy via EZH2 targeting. Drug Des Devel Ther 19:2897\u20132920. https:\/\/doi.org\/10.2147\/dddt.S508709","journal-title":"Drug Des Devel Ther"},{"issue":"5","key":"11584_CR88","doi-asserted-by":"publisher","first-page":"115652","DOI":"10.1016\/j.celrep.2025.115652","volume":"44","author":"A Gramatica","year":"2025","unstructured":"Gramatica A, Miller IG, Ward AR et al (2025) EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8(+) T cells toward less-exhausted phenotypes. Cell Rep 44(5):115652. https:\/\/doi.org\/10.1016\/j.celrep.2025.115652","journal-title":"Cell Rep"},{"issue":"1","key":"11584_CR89","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s40425-019-0784-9","volume":"7","author":"G Xiao","year":"2019","unstructured":"Xiao G, Jin LL, Liu CQ et al (2019) EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma. J Immunother Cancer 7(1):300. https:\/\/doi.org\/10.1186\/s40425-019-0784-9","journal-title":"J Immunother Cancer"},{"issue":"40","key":"11584_CR90","doi-asserted-by":"publisher","first-page":"eabo8043","DOI":"10.1126\/sciadv.abo8043","volume":"8","author":"A Piunti","year":"2022","unstructured":"Piunti A, Meghani K, Yu Y et al (2022) Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma. Sci Adv 8(40):eabo8043. https:\/\/doi.org\/10.1126\/sciadv.abo8043","journal-title":"Sci Adv"},{"key":"11584_CR91","doi-asserted-by":"publisher","first-page":"651406","DOI":"10.3389\/fcell.2021.651406","volume":"9","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Tian H, Zhou Z et al (2021) A novel immune-related prognostic model for response to immunotherapy and survival in patients with lung adenocarcinoma. Front Cell Dev Biol 9:651406. https:\/\/doi.org\/10.3389\/fcell.2021.651406","journal-title":"Front Cell Dev Biol"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11584-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11584-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11584-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:55:48Z","timestamp":1793814948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11584-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":91,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["11584"],"URL":"https:\/\/doi.org\/10.1007\/s11030-026-11584-5","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"29 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All data used in this study are publicly available, and thus no ethical approval was required.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}