{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:29:30Z","timestamp":1793860170916,"version":"4.6.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Guangdong Provincial Key Areas Research and Development Program of Universities in Biomedicine and Health","award":["2025ZDZX2088"],"award-info":[{"award-number":["2025ZDZX2088"]}]},{"name":"Scientific Research Program of Guangdong Industry Polytechnic University","award":["KJ2025-07"],"award-info":[{"award-number":["KJ2025-07"]}]},{"name":"the Joint Fund of Wuyi University-Macau","award":["2019WGALH01"],"award-info":[{"award-number":["2019WGALH01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-026-11651-x","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:56:09Z","timestamp":1783331769000},"page":"9943-9959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of novel cinnamic acid derivatives with anti-Helicobacter pylori mechanism"],"prefix":"10.1007","volume":"30","author":[{"given":"Yonglian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuya","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2019e","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"11651_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3390\/antibiotics12040765","volume":"12","author":"M Fiorani","year":"2023","unstructured":"Fiorani M, Tohumcu E, Del Vecchio LE, Porcari S, Cammarota G, Gasbarrini A, Ianiro G (2023) The influence of Helicobacter pylori on human gastric and gut microbiota. Antibiotics 12:765. https:\/\/doi.org\/10.3390\/antibiotics12040765","journal-title":"Antibiotics"},{"key":"11651_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/apt.12666","volume":"39","author":"MM Walker","year":"2024","unstructured":"Walker MM, Talley NJ (2024) Bacteria and pathogenesis of disease in the upper gastrointestinal tract\u2013beyond the era of Helicobacter pylori. Aliment Pharmacol Ther 39:767\u2013779. https:\/\/doi.org\/10.1111\/apt.12666","journal-title":"Aliment Pharmacol Ther"},{"key":"11651_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0928-4257(00)00160-1","volume":"94","author":"F Pakodi","year":"2000","unstructured":"Pakodi F, Abdel-Salam OM, Debreceni A, M\u00f3zsik G (2000) Helicobacter pylori. One bacterium and a broad spectrum of human disease! An overview. J Physiol Paris 94:139\u2013152. https:\/\/doi.org\/10.1016\/s0928-4257(00)00160-1","journal-title":"J Physiol Paris"},{"key":"11651_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10120-009-0507-x","volume":"12","author":"H Suzuki","year":"2009","unstructured":"Suzuki H, Iwasaki E, Hibi T (2009) Helicobacter pylori and gastric cancer. Gastric Canc 12:79\u201387. https:\/\/doi.org\/10.1007\/s10120-009-0507-x","journal-title":"Gastric Canc"},{"key":"11651_CR5","doi-asserted-by":"publisher","first-page":"630852","DOI":"10.3389\/fmicb.2021.630852","volume":"12","author":"M Piscione","year":"2021","unstructured":"Piscione M, Mazzone M, Di Marcantonio MC, Muraro R, Mincione G (2021) Eradication of Helicobacter pylori and gastric cancer: a controversial relationship. Front Microbiol 12:630852. https:\/\/doi.org\/10.3389\/fmicb.2021.630852","journal-title":"Front Microbiol"},{"key":"11651_CR6","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1136\/gutjnl-2020-320839","volume":"69","author":"AC Ford","year":"2020","unstructured":"Ford AC, Yuan Y, Moayyedi P (2020) Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis. Gut 69:2113\u20132121","journal-title":"Gut"},{"key":"11651_CR7","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1136\/gutjnl-2020-320839","volume":"39","author":"Y Yamaoka","year":"2024","unstructured":"Yamaoka Y (2024) Revolution of Helicobacter pylori treatment. J Gastroenterol Hepatol 39:1016\u20131026. https:\/\/doi.org\/10.1136\/gutjnl-2020-320839","journal-title":"J Gastroenterol Hepatol"},{"key":"11651_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000519413","volume":"103","author":"S Suzuki","year":"2022","unstructured":"Suzuki S, Kusano C, Horii T, Ichijima R, Ikehara H (2022) The ideal Helicobacter pylori treatment for the present and the future. Digestion 103:62\u201368. https:\/\/doi.org\/10.1159\/000519413","journal-title":"Digestion"},{"key":"11651_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/1871526523666230725103902","volume":"24","author":"JA Alara","year":"2024","unstructured":"Alara JA, Alara OR (2024) An overview of the global alarming increase of multiple drug resistant: a major challenge in clinical diagnosis. Infect Disord Drug Targets 24:26\u201342. https:\/\/doi.org\/10.2174\/1871526523666230725103902","journal-title":"Infect Disord Drug Targets"},{"key":"11651_CR10","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/1751-7915.13807","volume":"15","author":"J Jia","year":"2020","unstructured":"Jia J, Zhang C, Liu Y, Huang Y, Bai Y, Hang X, Zeng L, Zhu D, Bi H (2020) Armeniaspirol A: a novel anti-Helicobacter pylori agent. Microb Biotechnol 15:442\u2013454. https:\/\/doi.org\/10.1111\/1751-7915.13807","journal-title":"Microb Biotechnol"},{"key":"11651_CR11","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1080\/10408398.2022.2121255","volume":"64","author":"R Sweet","year":"2024","unstructured":"Sweet R, Kroon PA, Webber MA (2024) Activity of antibacterial phytochemicals and their potential use as natural food preservatives. Crit Rev Food Sci Nutr 64:2076\u20132087. https:\/\/doi.org\/10.1080\/10408398.2022.2121255","journal-title":"Crit Rev Food Sci Nutr"},{"key":"11651_CR12","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3390\/molecules28031068","volume":"28","author":"R Gonzalez-Pastor","year":"2023","unstructured":"Gonzalez-Pastor R, Carrera-Pacheco SE, Z\u00fa\u00f1iga-Miranda J, Rodr\u00edguez-P\u00f3lit C, Mayorga-Ramos A, Guam\u00e1n LP, Guam\u00e1n LP, Barba-Ostria C (2023) Current landscape of methods to evaluate antimicrobial activity of natural extracts. Molecules 28:1068. https:\/\/doi.org\/10.3390\/molecules28031068","journal-title":"Molecules"},{"key":"11651_CR13","doi-asserted-by":"publisher","first-page":"113669","DOI":"10.1016\/j.ejmech.2021.113669","volume":"223","author":"E Ghobadi","year":"2021","unstructured":"Ghobadi E, Ghanbarimasir Z, Emami S (2021) A review on the structures and biological activities of anti-Helicobacter pylori agents. Eur J Med Chem 223:113669. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113669","journal-title":"Eur J Med Chem"},{"key":"11651_CR14","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41575-021-00449-x","volume":"18","author":"E Tshibangu-Kabamba","year":"2021","unstructured":"Tshibangu-Kabamba E, Yamaoka Y (2021) Helicobacter pylori infection and antibiotic resistance-from biology to clinical implications. Nat Rev Gastroenterol Hepatol 18:613\u2013629. https:\/\/doi.org\/10.1038\/s41575-021-00449-x","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"11651_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.fitote.2016.05.016","volume":"12","author":"S Shreaz","year":"2016","unstructured":"Shreaz S, Wani WA, Behbehani JM, Raja V, Irshad M, Karched M, Ali I, Siddiqi WA, Lee TH (2016) Cinnamaldehyde and its constituents, a novel class of antifungal agents. Fitoterapia 12:116\u2013131. https:\/\/doi.org\/10.1016\/j.fitote.2016.05.016","journal-title":"Fitoterapia"},{"key":"11651_CR16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0378-8741(01)00273-2","volume":"77","author":"ST Chang","year":"2001","unstructured":"Chang ST, Chen PF, Chang SC (2001) Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. J Ethnopharmacol 77:123\u2013127. https:\/\/doi.org\/10.1016\/s0378-8741(01)00273-2","journal-title":"J Ethnopharmacol"},{"key":"11651_CR17","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.phymed.2010.08.008","volume":"18","author":"Z Lu","year":"2011","unstructured":"Lu Z, Jia Q, Wang R, Wu X, Wu Y, Huang C (2011) Hypoglycemic activities of A and B-type procyanidin oligomer-rich extracts from different Cinnamon barks. Phytomedicine 18:298\u2013302. https:\/\/doi.org\/10.1016\/j.phymed.2010.08.008","journal-title":"Phytomedicine"},{"key":"11651_CR18","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1016\/j.biortech.2007.07.050","volume":"99","author":"YT Tung","year":"2008","unstructured":"Tung YT, Chua MT, Wang SY, Chang ST (2008) Antiinflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol 99:3908\u20133913. https:\/\/doi.org\/10.1016\/j.biortech.2007.07.050","journal-title":"Bioresour Technol"},{"key":"11651_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/1471-2407-10-210","volume":"10","author":"SJ Koppikar","year":"2010","unstructured":"Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R (2010) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Canc 10:210. https:\/\/doi.org\/10.1186\/1471-2407-10-210","journal-title":"BMC Canc"},{"key":"11651_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.micpath.2018.04.036","volume":"120","author":"NG Vasconcelos","year":"2018","unstructured":"Vasconcelos NG, Croda J, Simionatto S (2018) Antibacterial mechanisms of cinnamon and its constituents: a review. Microb Pathog 120:198\u2013203. https:\/\/doi.org\/10.1016\/j.micpath.2018.04.036","journal-title":"Microb Pathog"},{"key":"11651_CR21","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/jat.2550040602","volume":"4","author":"JA Hoskins","year":"1984","unstructured":"Hoskins JA (1984) The occurrence, metabolism and toxicity of cinnamic acid and related compounds. J Appl Toxicol 4:283\u2013292. https:\/\/doi.org\/10.1002\/jat.2550040602","journal-title":"J Appl Toxicol"},{"key":"11651_CR22","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.3390\/ijms21165712","volume":"21","author":"N Ruwizhi","year":"2020","unstructured":"Ruwizhi N, Aderibigbe BA (2020) Cinnamic acid derivatives and their biological efficacy. Int J Mol Sci 21:5712. https:\/\/doi.org\/10.3390\/ijms21165712","journal-title":"Int J Mol Sci"},{"key":"11651_CR23","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41429-018-0027-1","volume":"71","author":"K Klesiewicz","year":"2018","unstructured":"Klesiewicz K, Karczewska E, Nowak P, Skiba-Kurek I, Sito E, Panczyk K, Gunia-Krzyzak A (2018) Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains. J Antibiot 71:543\u2013548. https:\/\/doi.org\/10.1038\/s41429-018-0027-1","journal-title":"J Antibiot"},{"key":"11651_CR24","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1016\/j.bmcl.2006.08.043","volume":"16","author":"F Epifano","year":"2006","unstructured":"Epifano F, Menghini L, Pagiotti R, Angelini P, Genovese S, Curini M (2006) In vitro inhibitory activity of boropinic acid against Helicobacter pylori. Bioorg Med Chem Lett 16:5523\u20135525. https:\/\/doi.org\/10.1016\/j.bmcl.2006.08.043","journal-title":"Bioorg Med Chem Lett"},{"key":"11651_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2174\/157340641001131226125042","volume":"10","author":"L de Chiquetto Paracatu","year":"2014","unstructured":"Chiquetto Paracatu L, Bonacorsi C, Maria Q, de Gomes C, Carolina Nazare A, Segalla Petronio M, Octavio Regasini L, Helena Siqueira Silva D, Stella Goncalves Raddi M, da Marcos L, Farias Ximenes V (2014) Alkyl caffeates as anti-helicobacter pylori and scavenger of oxidants produced by neutrophils. Med Chem 10:74\u201380. https:\/\/doi.org\/10.2174\/157340641001131226125042","journal-title":"Med Chem"},{"key":"11651_CR26","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/0968-0896(95)00043-g","volume":"3","author":"WS Faraci","year":"1995","unstructured":"Faraci WS, Yang BV, O\u2019Rourke D, Spencer RW (1995) Inhibition of Helicobacter pylori urease by phenyl phosphorodiamidates: mechanism of action. Bioorg Med Chem 3:605\u2013610. https:\/\/doi.org\/10.1016\/0968-0896(95)00043-g","journal-title":"Bioorg Med Chem"},{"key":"11651_CR27","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1021\/ac60252a045","volume":"39","author":"MW Weatherburn","year":"2002","unstructured":"Weatherburn MW (2002) Phenol-hypochlorite reaction for determination of ammonia. Anal Chem 39:971\u2013974. https:\/\/doi.org\/10.1021\/ac60252a045","journal-title":"Anal Chem"},{"key":"11651_CR28","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s42452-024-06107-6","volume":"6","author":"MT Bayode","year":"2024","unstructured":"Bayode MT, Awodire EF, Ojo EF, Adenikinju GO, Sadibo ME, Aro PO, Adeyolanu AE, Abbah PI, Oguntuase SS, Lawani BT, Bodun OL (2024) Phytophenolic derivatives as potential ameliorative agents for microbial superbugs: mechanisms of action, cellular pathways and synergistic selectivity with chemotherapeutics. Discov Appl Sci 6:484. https:\/\/doi.org\/10.1007\/s42452-024-06107-6","journal-title":"Discov Appl Sci"},{"key":"11651_CR29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ja.2010.7","volume":"63","author":"CH Gao","year":"2010","unstructured":"Gao CH, Tian XP, Qi SH, Luo XM, Wang P, Zhang S (2010) Antibacterial and antilarval compounds from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. J Antibiot 63:191\u2013193. https:\/\/doi.org\/10.1038\/ja.2010.7","journal-title":"J Antibiot"},{"key":"11651_CR30","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/1040841x.2024.2366944","volume":"51","author":"X Fei","year":"2025","unstructured":"Fei X, Li N, Xu X, Zhu Y (2025) Macrophage biology in the pathogenesis of Helicobacter pylori infection. Crit Rev Microbiol 51:399\u2013416. https:\/\/doi.org\/10.1080\/1040841x.2024.2366944","journal-title":"Crit Rev Microbiol"},{"key":"11651_CR31","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3390\/md17070404","volume":"17","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Hu X, Lin L, Ding G, Yu F (2019) Immunomodulatory activity of low molecular-weight peptides from Nibea japonica in RAW264. 7 cells via NF-\u03baB pathway. Mar Drugs 17:404. https:\/\/doi.org\/10.3390\/md17070404","journal-title":"Mar Drugs"},{"key":"11651_CR32","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.3390\/ijms22157856","volume":"22","author":"SM Lee","year":"2021","unstructured":"Lee SM, Son KN, Shah D, Ali M, Balasubramaniam A, Shukla D, Aakalu VK (2021) Histatin-1 attenuates LPS-induced inflammatory signaling in RAW264. 7 macrophages. Int J Mol Sci 22:7856. https:\/\/doi.org\/10.3390\/ijms22157856","journal-title":"Int J Mol Sci"},{"key":"11651_CR33","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/ph13110405","volume":"13","author":"F Sisto","year":"2020","unstructured":"Sisto F, Carradori S, Guglielmi P, Traversi CB, Spano M, Sobolev AP, Secci D, Di Marcantonio MC, Haloci E, Grande R, Mincione G (2020) Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of Hp strains and AGS cell proliferation. Pharmaceuticals 13:405. https:\/\/doi.org\/10.3390\/ph13110405","journal-title":"Pharmaceuticals"},{"key":"11651_CR34","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.3390\/molecules29194548","volume":"29","author":"Y Li","year":"2024","unstructured":"Li Y, Zhao K, Wu Z, Zheng Y, Yu J, Wu S, Wong VKW, Chen M, Liu W, Zhao S (2024) Discovery of cinnamic acid derivatives as potent anti-Hp agents. Molecules 29:4548. https:\/\/doi.org\/10.3390\/molecules29194548","journal-title":"Molecules"},{"key":"11651_CR35","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1128\/jb.185.16.4806-4815.2003","volume":"185","author":"KA Kalivoda","year":"2003","unstructured":"Kalivoda KA, Steenbergen SM, Vimr ER, Plumbridge J (2003) Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. J Bacteriol 185:4806\u20134815. https:\/\/doi.org\/10.1128\/jb.185.16.4806-4815.2003","journal-title":"J Bacteriol"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11651-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11651-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11651-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:03:26Z","timestamp":1793858606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11651-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["11651"],"URL":"https:\/\/doi.org\/10.1007\/s11030-026-11651-x","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"24 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}