{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:07:06Z","timestamp":1788959226171,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Divers"],"DOI":"10.1007\/s11030-026-11720-1","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:21:03Z","timestamp":1788956463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hot spot-driven discovery of \u03b2-catenin\/Tcf4 interaction inhibitors via virtual drug repurposing study and experimental validation in colorectal cancer cells"],"prefix":"10.1007","author":[{"given":"Kader","family":"Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajda","family":"Coker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Durda\u011f\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"3","key":"11720_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","volume":"127","author":"H Clevers","year":"2006","unstructured":"Clevers H (2006) Wnt\/beta-catenin signaling in development and disease. Cell 127(3):469\u2013480","journal-title":"Cell"},{"issue":"1","key":"11720_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc3419","volume":"13","author":"JN Anastas","year":"2013","unstructured":"Anastas JN, Moon RT (2013) WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 13(1):11\u201326","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"11720_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0092-8674(00)00122-7","volume":"103","author":"M Bienz","year":"2000","unstructured":"Bienz M, Clevers H (2000) Linking colorectal cancer to Wnt signaling. Cell 103(2):311\u2013320","journal-title":"Cell"},{"issue":"5","key":"11720_CR4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0092-8674(00)80352-9","volume":"90","author":"AH Huber","year":"1997","unstructured":"Huber AH, Nelson WJ, Weis WI (1997) Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 90(5):871\u2013882","journal-title":"Cell"},{"issue":"2","key":"11720_CR5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.molcel.2006.09.001","volume":"24","author":"J Sampietro","year":"2006","unstructured":"Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006) Crystal structure of a beta-catenin\/BCL9\/Tcf4 complex. Mol Cell 24(2):293\u2013300","journal-title":"Mol Cell"},{"issue":"6","key":"11720_CR6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0092-8674(00)00192-6","volume":"103","author":"TA Graham","year":"2000","unstructured":"Graham TA, Weaver C, Mao F, Kimelman D, Xu W (2000) Crystal structure of a beta-catenin\/Tcf complex. Cell 103(6):885\u2013896","journal-title":"Cell"},{"key":"11720_CR7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/cancers8010007","volume":"8","author":"EMF de Sousa","year":"2016","unstructured":"de Sousa EMF, Vermeulen L (2016) Wnt signaling in cancer stem cell biology. Cancers 8:7","journal-title":"Cancers"},{"issue":"8","key":"11720_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.2174\/1568009043332709","volume":"4","author":"HH Luu","year":"2004","unstructured":"Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, Park JK, Wang H, Peng Y, Jiang W, He TC (2004) Wnt\/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets 4(8):653\u2013671","journal-title":"Curr Cancer Drug Targets"},{"issue":"12","key":"11720_CR9","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nrd2154","volume":"5","author":"N Barker","year":"2006","unstructured":"Barker N, Clevers H (2006) Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5(12):997\u20131014","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"11720_CR10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nchembio.137","volume":"5","author":"B Chen","year":"2009","unstructured":"Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5(2):100\u2013107","journal-title":"Nat Chem Biol"},{"issue":"12","key":"11720_CR11","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1158\/1078-0432.CCR-09-2943","volume":"16","author":"F Takahashi-Yanaga","year":"2010","unstructured":"Takahashi-Yanaga F, Kahn M (2010) Targeting Wnt signaling: Can we safely eradicate cancer stem cells? Clin Cancer Res Off J Am Assoc Cancer Res 16(12):3153\u20133162","journal-title":"Clin cancer research: official J Am Association Cancer Res"},{"issue":"1","key":"11720_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1021\/cb400795x","volume":"9","author":"Z Huang","year":"2014","unstructured":"Huang Z, Zhang M, Burton SD, Katsakhyan LN, Ji H (2014) Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt \u03b2-catenin\/T-cell factor protein-protein interactions. ACS Chem Biol 9(1):193\u2013201","journal-title":"ACS Chem Biol"},{"issue":"2","key":"11720_CR13","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1021\/bi201428h","volume":"51","author":"W Tian","year":"2012","unstructured":"Tian W, Han X, Yan M, Xu Y, Duggineni S, Lin N, Luo G, Li YM, Han X, Huang Z, An J (2012) Structure-based discovery of a novel inhibitor targeting the \u03b2-catenin\/Tcf4 interaction. Biochemistry 51(2):724\u2013731","journal-title":"Biochemistry"},{"issue":"9","key":"11720_CR14","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.21873\/anticanres.14524","volume":"40","author":"R Gabata","year":"2020","unstructured":"Gabata R, Harada K, Mizutani Y, Ouchi H, Yoshimura K, Sato Y, Kitao A, Kimura K, Kouji H, Miyashita T, Tajima H, Ohta T (2020) Anti-tumor activity of the small molecule inhibitor PRI-724 against \u03b2-catenin-activated hepatocellular carcinoma. Anticancer Res 40(9):5211\u20135219","journal-title":"Anticancer Res"},{"issue":"10","key":"11720_CR15","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1002\/ijc.24810","volume":"126","author":"W Wei","year":"2010","unstructured":"Wei W, Chua MS, Grepper S, So S (2010) Small molecule antagonists of Tcf4\/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer 126(10):2426\u20132436","journal-title":"Int J Cancer"},{"key":"11720_CR16","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13321-025-01067-4","volume":"17","author":"J G\u00f3mez Borrego","year":"2025","unstructured":"G\u00f3mez Borrego J, Torrent Burgas M (2025) Evaluating ligand docking methods for drugging protein\u2013protein interfaces: insights from AlphaFold2 and molecular dynamics refinement. J Cheminform 17:144. https:\/\/doi.org\/10.1186\/s13321-025-01067-4","journal-title":"J Cheminform"},{"key":"11720_CR17","doi-asserted-by":"publisher","first-page":"17374","DOI":"10.1039\/D5SC05395A","volume":"16","author":"Y Li","year":"2025","unstructured":"Li Y, Yi J, Li H, Li K, Kang F, Deng Y, Wu C, Fu X, Jiang D, Cao D (2025) Decoding the limits of deep learning in molecular docking for drug discovery. Chem Sci 16:17374\u201317390","journal-title":"Chem Sci"},{"issue":"2","key":"11720_CR18","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/157340911795677602","volume":"7","author":"XY Meng","year":"2011","unstructured":"Meng XY, Zhang HX, Mezei M, Cui M (2011) Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput-Aided Drug Design 7(2):146\u2013157. https:\/\/doi.org\/10.2174\/157340911795677602","journal-title":"Curr Comput-Aided Drug Design"},{"issue":"3","key":"11720_CR19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","volume":"27","author":"GM Sastry","year":"2013","unstructured":"Sastry GM, Adzhigirey M, Day T, Annabhimoju R, Sherman W (2013) Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments. J Comput Aided Mol Des 27(3):221\u2013234","journal-title":"J Comput Aided Mol Des"},{"issue":"80","key":"11720_CR20","doi-asserted-by":"publisher","first-page":"80ps16","DOI":"10.1126\/scitranslmed.3001862","volume":"3","author":"R Huang","year":"2011","unstructured":"Huang R et al (2011) The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med 3(80):80ps16\u201380ps16. https:\/\/doi.org\/10.1126\/scitranslmed.3001862","journal-title":"Sci Transl Med"},{"key":"11720_CR21","unstructured":"Schr\u00f6dinger (2018) 2018-4: LigPrep, Schr\u00f6dinger, LLC, New York, NY"},{"issue":"13","key":"11720_CR22","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1002\/jcc.21859","volume":"32","author":"J Du","year":"2011","unstructured":"Du J, Sun H, Xi L, Li J, Yang Y, Liu H, Yao X (2011) Molecular modeling study of checkpoint kinase 1 inhibitors by multiple docking strategies and prime\/MM-GBSA calculation. J Comput Chem 32(13):2800\u20132809","journal-title":"J Comput Chem"},{"issue":"1","key":"11720_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/prot.21082","volume":"65","author":"SF Sousa","year":"2006","unstructured":"Sousa SF, Fernandes PA, Ramos MJ (2006) Protein-ligand docking: current status and future challenges. Proteins 65(1):15\u201326","journal-title":"Proteins"},{"issue":"1","key":"11720_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.celrep.2016.05.071","volume":"16","author":"SY Hwang","year":"2016","unstructured":"Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW (2016) Direct targeting of \u03b2-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt\/\u03b2-catenin signaling. Cell Rep 16(1):28\u201336. https:\/\/doi.org\/10.1016\/j.celrep.2016.05.071","journal-title":"Cell Rep"},{"key":"11720_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bioactmat.2024.10.023","volume":"46","author":"K Lu","year":"2025","unstructured":"Lu K, Liao Z, Li J, Wang Y, Zhang Y, Cai L, Lu WW, Yang F, Pan H, Chen D (2025) MSAB limits osteoarthritis development and progression through inhibition of \u03b2-catenin-DDR2 signaling. Bioactive Mater 46:259\u2013272. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.10.023","journal-title":"Bioactive Mater"},{"issue":"3","key":"11720_CR26","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1021\/acsptsci.0c00210","volume":"4","author":"K Sahin","year":"2021","unstructured":"Sahin K, Orhan MD, Avsar T, Durdagi S (2021) Hybrid in silico and TR-FRET-guided discovery of novel BCL-2 inhibitors. ACS Pharmacol Transl Sci 4(3):1111\u20131123","journal-title":"ACS Pharmacol translational Sci"},{"issue":"11","key":"11720_CR27","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1080\/07391102.2019.1660218","volume":"38","author":"K Sahin","year":"2020","unstructured":"Sahin K, Zengin Kurt B, Sonmez F, Durdagi S (2020) Novel AChE and BChE inhibitors using combined virtual screening, text mining and in vitro binding assays. J Biomol Struct Dyn 38(11):3342\u20133358","journal-title":"J Biomol Struct Dyn"},{"key":"11720_CR28","doi-asserted-by":"publisher","first-page":"991369","DOI":"10.3389\/fchem.2022.991369","volume":"10","author":"U Dasmahapatra","year":"2022","unstructured":"Dasmahapatra U, Kumar CK, Das S, Subramanian PT, Murali P, Isaac AE, Ramanathan K, Mm B, Chanda K (2022) In-silico molecular modelling, MM\/GBSA binding free energy and molecular dynamics simulation study of novel pyrido fused imidazo[4,5-c]quinolines as potential anti-tumor agents. Front Chem 10:991369","journal-title":"Front Chem"},{"issue":"5036","key":"11720_CR29","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1126\/science.1962194","volume":"254","author":"PD McCrea","year":"1991","unstructured":"McCrea PD, Turck CW, Gumbiner B (1991) A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Sci (New York N Y) 254(5036):1359\u20131361","journal-title":"Sci (New York N Y)"},{"issue":"9","key":"11720_CR30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0168-9525(93)90250-L","volume":"9","author":"R Kemler","year":"1993","unstructured":"Kemler R (1993) From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 9(9):317\u2013321","journal-title":"Trends Genet"},{"issue":"6205","key":"11720_CR31","doi-asserted-by":"publisher","first-page":"1248012","DOI":"10.1126\/science.1248012","volume":"346","author":"H Clevers","year":"2014","unstructured":"Clevers H, Loh KM, Nusse R (2014) Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Sci (New York N Y) 346(6205):1248012","journal-title":"Sci (New York N Y)"},{"issue":"1","key":"11720_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S1476-5586(04)80048-4","volume":"6","author":"B He","year":"2004","unstructured":"He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons DM (2004) A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia (New York N Y) 6(1):7\u201314","journal-title":"Neoplasia (New York N Y)"},{"issue":"36","key":"11720_CR33","doi-asserted-by":"publisher","first-page":"6170","DOI":"10.1038\/sj.onc.1207844","volume":"23","author":"L You","year":"2004","unstructured":"You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons DM (2004) Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene 23(36):6170\u20136174","journal-title":"Oncogene"},{"issue":"5382","key":"11720_CR34","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"TC He","year":"1998","unstructured":"He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Sci (New York N Y) 281(5382):1509\u20131512","journal-title":"Sci (New York N Y)"},{"issue":"5","key":"11720_CR35","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/S0002-9440(10)63732-7","volume":"164","author":"M Saegusa","year":"2004","unstructured":"Saegusa M, Hashimura M, Kuwata T, Hamano M, Okayasu I (2004) Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells. Am J Pathol 164(5):1739\u20131749","journal-title":"Am J Pathol"},{"issue":"44","key":"11720_CR36","doi-asserted-by":"publisher","first-page":"42386","DOI":"10.1074\/jbc.M207418200","volume":"277","author":"L L\u00e9vy","year":"2002","unstructured":"L\u00e9vy L, Neuveut C, Renard CA, Charneau P, Branchereau S, Gauthier F, Van Nhieu JT, Cherqui D, Petit-Bertron AF, Mathieu D, Buendia MA (2002) Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem 277(44):42386\u201342393","journal-title":"J Biol Chem"},{"issue":"17","key":"11720_CR37","first-page":"4761","volume":"60","author":"T Yamada","year":"2000","unstructured":"Yamada T, Takaoka AS, Naishiro Y, Hayashi R, Maruyama K, Maesawa C, Ochiai A, Hirohashi S (2000) Transactivation of the multidrug resistance 1 gene by T-cell factor 4\/beta-catenin complex in early colorectal carcinogenesis. Cancer Res 60(17):4761\u20134766","journal-title":"Cancer Res"},{"issue":"1\u20132","key":"11720_CR38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.gene.2008.12.002","volume":"432","author":"A Lapham","year":"2009","unstructured":"Lapham A, Adams JE, Paterson A, Lee M, Brimmell M, Packham G (2009) The Bcl-w promoter is activated by beta-catenin\/TCF4 in human colorectal carcinoma cells. Gene 432(1\u20132):112\u2013117","journal-title":"Gene"},{"issue":"48","key":"11720_CR39","doi-asserted-by":"publisher","first-page":"19204","DOI":"10.1073\/pnas.1108977108","volume":"108","author":"E S\u00e1nchez-Till\u00f3","year":"2011","unstructured":"S\u00e1nchez-Till\u00f3 E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A (2011) \u03b2-catenin\/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci USA 108(48):19204\u201319209","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"11720_CR40","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/nsb720","volume":"8","author":"F Poy","year":"2001","unstructured":"Poy F, Lepourcelet M, Shivdasani RA, Eck MJ (2001) Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol 8(12):1053\u20131057","journal-title":"Nat Struct Biol"},{"issue":"1","key":"11720_CR41","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/prot.20955","volume":"64","author":"JY Trosset","year":"2006","unstructured":"Trosset JY, Dalvit C, Knapp S, Fasolini M, Veronesi M, Mantegani S, Gianellini LM, Catana C, Sundstr\u00f6m M, Stouten PF, Moll JK (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64(1):60\u201367","journal-title":"Proteins"},{"issue":"23","key":"11720_CR42","doi-asserted-by":"publisher","first-page":"21092","DOI":"10.1074\/jbc.M301781200","volume":"278","author":"M Fasolini","year":"2003","unstructured":"Fasolini M, Wu X, Flocco M, Trosset JY, Oppermann U, Knapp S (2003) Hot spots in Tcf4 for the interaction with beta-catenin. J Biol Chem 278(23):21092\u201321098","journal-title":"J Biol Chem"},{"issue":"32","key":"11720_CR43","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.2174\/092986712803833245","volume":"19","author":"XH Ma","year":"2012","unstructured":"Ma XH, Zhu F, Liu X, Shi Z, Zhang JX, Yang SY, Wei YQ, Chen YZ (2012) Virtual screening methods as tools for drug lead discovery from large chemical libraries. Curr Med Chem 19(32):5562\u20135571","journal-title":"Curr Med Chem"},{"key":"11720_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-62703-342-8_1","volume":"993","author":"M Lill","year":"2013","unstructured":"Lill M (2013) Virtual screening in drug design. Methods Mol Biol. (Clifton N J) 993:1\u201312","journal-title":"Methods Mol biology (Clifton N J)"},{"issue":"1","key":"11720_CR45","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.celrep.2016.05.071","volume":"16","author":"SY Hwang","year":"2016","unstructured":"Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW (2016) Direct targeting of \u03b2-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt\/\u03b2-catenin signaling. Cell Rep 16(1):28\u201336","journal-title":"Cell Rep"},{"issue":"1","key":"11720_CR46","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41698-023-00480-y","volume":"7","author":"M Le Compte","year":"2023","unstructured":"Le Compte M, De La Hoz EC, Peeters S, Fortes FR, Hermans C, Domen A, Smits E, Lardon F, Vandamme T, Lin A, Vanlanduit S, Roeyen G, Van Laere S, Prenen H, Peeters M, Deben C (2023) Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer. NPJ Precision Oncol 7(1):128","journal-title":"NPJ precision Oncol"},{"issue":"7","key":"11720_CR47","doi-asserted-by":"publisher","first-page":"6733","DOI":"10.3390\/ijms24076733","volume":"24","author":"N Pe\u0107ina-\u0160laus","year":"2023","unstructured":"Pe\u0107ina-\u0160laus N, Ani\u010di\u0107 S, Bukovac A, Kafka A (2023) Wnt signaling inhibitors and their promising role in tumor treatment. Int J Mol Sci 24(7):6733","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Diversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11720-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11030-026-11720-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11030-026-11720-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:21:07Z","timestamp":1788956467000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11030-026-11720-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":47,"alternative-id":["11720"],"URL":"https:\/\/doi.org\/10.1007\/s11030-026-11720-1","relation":{},"ISSN":["1573-501X"],"issn-type":[{"value":"1573-501X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"4 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involved computational analyses, including molecular docking and molecular dynamics simulations, as well as in vitro experiments using established human cell lines. No primary human participants or animals were used, and therefore ethical approval was not required. All cell lines were handled in accordance with institutional biosafety and ethical guidelines.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}