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Human data were obtained from publicly available, de-identified datasets. NHANES protocols were approved by the NCHS IRB with written informed consent from participants, and the GSE174748 human liver single-nucleus RNA-seq data were obtained from GEO. No human participants or tissues were directly recruited or collected by the authors; therefore, no additional ethical approval was required for this secondary analysis.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}