{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:43:57Z","timestamp":1774982637910,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s11033-007-9077-3","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T09:24:36Z","timestamp":1174555476000},"page":"251-256","source":"Crossref","is-referenced-by-count":37,"title":["Primary function analysis of human mental retardation related gene CRBN"],"prefix":"10.1007","volume":"35","author":[{"given":"Wang","family":"Xin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Xiaohua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Peilin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Yaqiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Qihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"9077_CR1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1096-8628(19971112)72:4<468::AID-AJMG18>3.0.CO;2-P","volume":"72","author":"CJ Curry","year":"1997","unstructured":"Curry CJ, Stevenson RE, Aughton D et al (1997) Evaluation of mental retardation: recommendations of a Consensus Conference: American College of Medical Genetics. Am J Med Genet 72:468\u2013477","journal-title":"Am J Med Genet"},{"key":"9077_CR2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archpedi.1959.02070010447010","volume":"97","author":"SW Wright","year":"1959","unstructured":"Wright SW, Tarjan G, Eyer L (1959) Investigation of families with two or more mentally defective siblings; clinical observations. Am J Dis Child 97: 445\u2013463","journal-title":"Am J Dis Child"},{"key":"9077_CR3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng0197-74","volume":"15","author":"T Matsuura","year":"1997","unstructured":"Matsuura T, Sutcliffe JS, Fang P et al (1997) De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat Genet 15:74\u201377","journal-title":"Nat Genet"},{"key":"9077_CR4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/ng0997-75","volume":"17","author":"U Albrecht","year":"1997","unstructured":"Albrecht U, Sutcliffe JS, Cattanach BM et al (1997) Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. Nat Genet 17:75\u201378","journal-title":"Nat Genet"},{"key":"9077_CR5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nature711","volume":"415","author":"RM Costa","year":"2002","unstructured":"Costa RM, Federov NB, Kogan JH et al (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415:526\u2013530","journal-title":"Nature"},{"key":"9077_CR6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.273.5277.959","volume":"273","author":"J Xing","year":"1996","unstructured":"Xing J, Ginty DD, Greenberg ME (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273:959\u2013963","journal-title":"Science"},{"key":"9077_CR7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0926-6410(00)00074-4","volume":"35","author":"Z Galdzicki","year":"2001","unstructured":"Galdzicki Z, Siarey R, Pearce R et al (2001) On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Rev 35:115\u2013145","journal-title":"Brain Res Rev"},{"key":"9077_CR8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","volume":"35","author":"M Shahbazian","year":"2002","unstructured":"Shahbazian M, Young J, Yuva-Paylor L et al (2002) Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35:243\u2013254","journal-title":"Neuron"},{"key":"9077_CR9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/376348a0","volume":"376","author":"F Petrij","year":"1995","unstructured":"Petrij F, Giles RH, Dauwerse HG et al (1995) Rubinstein\u2013Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376:348\u2013351","journal-title":"Nature"},{"key":"9077_CR10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1126\/science.8036515","volume":"265","author":"YH Wang","year":"1994","unstructured":"Wang YH, Amirhaeri S, Kang S et al (1994) Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene. Science 265:669\u2013671","journal-title":"Science"},{"key":"9077_CR11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(01)00566-9","volume":"107","author":"JC Darnell","year":"2001","unstructured":"Darnell JC, Jensen KB, Jin P et al (2001) Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107:489\u2013499","journal-title":"Cell"},{"key":"9077_CR12","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1074\/jbc.M311913200","volume":"279","author":"EJ Yang","year":"2004","unstructured":"Yang EJ, Yoon JH, Min do S et al (2004) LIM kinase 1 activates cAMP-responsive element-binding protein during the neuronal differentiation of immortalized hippocampal progenitor cells. J Biol Chem 279:8903\u20138910","journal-title":"J Biol Chem"},{"key":"9077_CR13","first-page":"1921","volume":"63","author":"JH Joseph","year":"2004","unstructured":"Joseph JH, Joanna P, Roni QL et al (2004) A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. Neurology 63:1921\u20131931","journal-title":"Neurology"},{"key":"9077_CR14","doi-asserted-by":"crossref","first-page":"10232","DOI":"10.1073\/pnas.88.22.10232","volume":"88","author":"C Charriaut-Marlangue","year":"1991","unstructured":"Charriaut-Marlangue C, Otani S, Creuzet C et al (1991) Rapid activation of hippocampal casein kinase II during long-term potentiation. Proc Natl Acad Sci USA 88:10232\u201310236","journal-title":"Proc Natl Acad Sci USA"},{"key":"9077_CR15","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/JB.164.3.1124-1135.1985","volume":"164","author":"MR Maurizi","year":"1985","unstructured":"Maurizi MR, Trisler P, Gottesman S (1985) Insertional mutagenesis of the lon gene in Escherichia coli: lon is dispensable. J Bacteriol 164:1124\u20131135","journal-title":"J Bacteriol"},{"key":"9077_CR16","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1016\/S0021-9258(18)61221-9","volume":"262","author":"SA Goff","year":"1987","unstructured":"Goff SA, Goldberg AL (1987) An increased content of protease La, the lon gene product, increases protein degradation and blocks growth in Escherichia coli. J Biol Chem 262:4508\u20134515","journal-title":"J Biol Chem"},{"key":"9077_CR17","first-page":"1212","volume":"94","author":"J Sooyeon","year":"2005","unstructured":"Sooyeon J, Kwang-Hee L, Sungmin S et al (2005) Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. J Neuro chem 94:1212\u20131224","journal-title":"J Neuro chem"},{"key":"9077_CR18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-1119(03)00403-7","volume":"306","author":"B Lu","year":"2003","unstructured":"Lu B, Liu T, Crosby JA et al (2003) The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals. Gene 306:45\u201355","journal-title":"Gene"},{"key":"9077_CR19","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1073\/pnas.90.23.11247","volume":"90","author":"N Wang","year":"1993","unstructured":"Wang N, Gottesman S, Willingham MC et al (1993) A human mitochondrial ATPdependent protease that is highly homologous to bacterial Lon protease. Proc Natl Acad Sci USA 90:11247\u201311251","journal-title":"Proc Natl Acad Sci USA"},{"key":"9077_CR20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jmg.40.10.729","volume":"40","author":"L Basel-Vanagaite","year":"2003","unstructured":"Basel-Vanagaite L, Alkelai A, Straussberg R et al (2003) Mapping of a new locus for autosomal recessive non-syndromic mental retardation in the chromosomal region 19p13.12-p13.2: further genetic heterogeneity. J Med Genet 40:729\u2013732","journal-title":"J Med Genet"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-007-9077-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-007-9077-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-007-9077-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T17:19:00Z","timestamp":1628702340000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-007-9077-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,23]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["9077"],"URL":"https:\/\/doi.org\/10.1007\/s11033-007-9077-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,23]]}}}