{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:07:57Z","timestamp":1767902877157,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/s11033-010-0268-y","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T06:57:27Z","timestamp":1285916247000},"page":"1593-1601","source":"Crossref","is-referenced-by-count":17,"title":["The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab\/ac"],"prefix":"10.1007","volume":"38","author":[{"given":"Huayuan","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,2]]},"reference":[{"key":"268_CR1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/IAI.6.6.918-927.1972","volume":"6","author":"GW Jones","year":"1972","unstructured":"Jones GW, Rutter JM (1972) Role of K88 antigen in the pathogenesis of neonatal diarrhea caused by Escherichia coli in piglets. Infect Immun 6:918\u2013927","journal-title":"Infect Immun"},{"key":"268_CR2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0378-1135(99)00046-2","volume":"67","author":"C Choi","year":"1999","unstructured":"Choi C, Chae C (1999) Genotypic prevalence of F4 variants (ab, ac and ad) in Escherichia coli isolated from diarrheic piglets in Korea. Vet Microbiol 67:307\u2013310. doi: 10.1016\/S0378-1135(99)00046-2","journal-title":"Vet Microbiol"},{"key":"268_CR3","first-page":"175","volume":"64","author":"MM Henton","year":"1997","unstructured":"Henton MM, Engelbrecht MM (1997) Escherichia coli serotypes in pigs in South Africa. Onderstepoort J Vet Res 64:175\u2013187","journal-title":"Onderstepoort J Vet Res"},{"key":"268_CR4","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1128\/jb.169.11.4907-4911.1987","volume":"169","author":"AAC Jacobs","year":"1987","unstructured":"Jacobs AAC, Roosendaal B, van Breemen JFL, de Graaf FK (1987) Role of phenylalanine 150 in the receptor-binding domain of the K88 fimbrillar subunit. J Bacteriol 169:4907\u20134911. doi: 0021-9193\/87\/114907-05$02.00\/0","journal-title":"J Bacteriol"},{"key":"268_CR5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-1135(96)01277-1","volume":"54","author":"DR Baker","year":"1997","unstructured":"Baker DR, Billey LO, Francis DH (1997) Distribution of K88 Escherichia coli-adhesive and nonadhesive phenotypes among pigs of four breeds. Vet Microbiol 54:123\u2013132. doi: 10.1016\/S0378-1135(96)01277-1","journal-title":"Vet Microbiol"},{"key":"268_CR6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6968.1979.tb03237.x","volume":"5","author":"FR Mooi","year":"1979","unstructured":"Mooi FR, de Graaf FK (1979) Isolation and characterization of K88 antigens. FEMS Microbiol Lett 5:17\u201320","journal-title":"FEMS Microbiol Lett"},{"key":"268_CR7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1348-0421.1995.tb03296.x","volume":"39","author":"EA Gonzalez","year":"1995","unstructured":"Gonzalez EA, Vazques F, Ignacio J, Blanco J (1995) Isolation of K88 antigen variants (ab, ac, ad) from porcine enterotoxigenic Escherichia coli belonging to different serotypes. Microbiol Immunol 39:937\u2013942","journal-title":"Microbiol Immunol"},{"key":"268_CR8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00299479","volume":"51","author":"RA Gibbons","year":"1977","unstructured":"Gibbons RA, Sellwood R, Burrows MR, Hunter PA (1977) Inheritance of resistance to neonatal E. coli diarrhoea in the pig: examination of the genetic system. Theor Appl Genet 51:65\u201370. doi: 10.1007\/BF00299479","journal-title":"Theor Appl Genet"},{"key":"268_CR9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/vr.105.10.228","volume":"105","author":"R Sellwood","year":"1979","unstructured":"Sellwood R (1979) Escherichia coli diarrhea in pigs with and without the K88 receptor. Vet Rec 105:228\u2013230","journal-title":"Vet Rec"},{"key":"268_CR10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2052.1995.tb03250.x","volume":"26","author":"I Edfors-Lilja","year":"1995","unstructured":"Edfors-Lilja I, Gustafsson U, Duval-Iflah Y, Ellegren H, Johansson M, Juneja K, Marklund L, Andersson L (1995) The porcine intestinal receptor for Escherichia coli F4ab, F4ac:regional localization on chromosome 13 and influence of IgG response to the F4 antigen. Anim Genet 26:237\u2013242. doi: 10.1111\/j.1365-2052.1995.tb03250.x","journal-title":"Anim Genet"},{"key":"268_CR11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2052.2002.00915.x","volume":"33","author":"P Python","year":"2002","unstructured":"Python P, J\u00f6rg H, Neuenschwander S, Hagger C, Stricker C, B\u00fcrgi E, Bertschinger HU, Stranzinger G, V\u00f6geli P (2002) Fine-mapping of the intestinal receptor locus for enterotoxigenic Escherichia coli F4ac on porcine chromosome 13. Anim Genet 33:441\u2013447. doi: 10.1046\/j.1365-2052.2002.00915.x","journal-title":"Anim Genet"},{"key":"268_CR12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000075742","volume":"102","author":"CB J\u00f8rgensen","year":"2003","unstructured":"J\u00f8rgensen CB, Cirera S, Anderson SL, Archibald AL, Raudsepp T, Chowdhary B, Edfors-Lilja I, Anderssone L, Fredholma M (2003) Linkage and comparative mapping of the locus controlling susceptibility towards E. coli F4ab\/ac diarrhoea in pigs. Cytogenet Genome Res 102:157\u2013162. doi: 10.1159\/000075742","journal-title":"Cytogenet Genome Res"},{"key":"268_CR13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2052.2009.01952.x","volume":"41","author":"M Jacobsen","year":"2010","unstructured":"Jacobsen M, Kracht SS, Esteso G, Cirera S, Edfors I, Archibald AL, Bendixen C, Andersson L, Fredholm M, J\u00f8rgensen CB (2010) Refined candidate region specified by haplotype sharing for Escherichia coli F4ab\/F4ac susceptibility alleles in pigs. Anim Genet 41:21\u201325. doi: 10.1111\/j.1365-2052.2009.01952.x","journal-title":"Anim Genet"},{"key":"268_CR14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1439-0388.2008.00751.x","volume":"126","author":"J Ren","year":"2009","unstructured":"Ren J, Tang H, Yan XM, Huang X, Zhang B, Ji HY, Huang LS (2009) A pig-human comparative RH map comprising 20 genes on pig chromosome 13q41 that harbors the ETEC F4ac receptor locus. J Anim Breed Genet 126:30\u201336. doi: 10.1111\/j.1439-0388.2008.00751.x","journal-title":"J Anim Breed Genet"},{"key":"268_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-4598-2-9","volume":"2","author":"J Ringel","year":"2003","unstructured":"Ringel J, L\u00f6hr M (2003) The MUC gene family: their role in diagnosis and early detection of pancreatic cancer. Mol Cancer 2:9. doi: 10.1186\/1476-4598-2-9","journal-title":"Mol Cancer"},{"key":"268_CR16","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1074\/jbc.M304558200","volume":"279","author":"T Higuchi","year":"2004","unstructured":"Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe H, Yamasaki Y, Waga I, Nanayama T, Yamamoto Y, Munger W, Sun HW, Falk RJ, Jennette JC, Alcorta DA, Li H, Yamamoto T, Saito Y, Nakamura M (2004) Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. J Biol Chem 279:1968\u20131979. doi: 10.1074\/jbc.M304558200","journal-title":"J Biol Chem"},{"key":"268_CR17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2052.2008.01721.x","volume":"39","author":"B Zhang","year":"2008","unstructured":"Zhang B, Ren J, Yan XM, Huang X, Ji HY, Peng QL, Zhang ZY, Huang LS (2008) Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab\/ac. Anim Genet 39:258\u2013266. doi: 10.1111\/j.1365-2052.2008.01721.x","journal-title":"Anim Genet"},{"key":"268_CR18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/bioinformatics\/bth388","volume":"21","author":"K Zhang","year":"2005","unstructured":"Zhang K, Sun F, Zhao H (2005) HAPLORE: a program for haplotype reconstruction in general pedigrees without recombination. Bioinformatics 21:90\u2013103. doi: 10.1093\/bioinformatics\/bth388","journal-title":"Bioinformatics"},{"key":"268_CR19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1086\/302577","volume":"65","author":"D Clayton","year":"1999","unstructured":"Clayton D (1999) A generalization of the transmission\/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65:1170\u20131177. doi: 10.1086\/302577","journal-title":"Am J Hum Genet"},{"key":"268_CR20","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/bioinformatics\/bth071","volume":"20","author":"JH Zhao","year":"2004","unstructured":"Zhao JH (2004) 2LD GENECOUNTING and HAP: computer programs for linkage disequilibrium analysis. Bioinformatics 20:1325\u20131326. doi: 10.1093\/bioinformatics\/bth071","journal-title":"Bioinformatics"},{"key":"268_CR21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0968-0004(01)02052-7","volume":"27","author":"J Dekker","year":"2002","unstructured":"Dekker J, Rossen JWA, B\u00fcller HA, Einerhand AWC (2002) The MUC family: an obituary. Trends Biochem Sci 27:126\u2013131. doi: 10.1016\/S0968-0004(01)02052-7","journal-title":"Trends Biochem Sci"},{"key":"268_CR22","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/humrep\/del164","volume":"21","author":"CL Russo","year":"2006","unstructured":"Russo CL, Spurr-Michaud S, Tisdale A, Pudney J, Anderson D, Gipson IK (2006) Mucin gene expression in human male urogenital tract epithelia. Hum Reprod 21:2783\u20132793. doi: 10.1093\/humrep\/del164","journal-title":"Hum Reprod"},{"key":"268_CR23","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1099\/jmm.0.009803-0","volume":"58","author":"X Yan","year":"2009","unstructured":"Yan X, Huang X, Ren J, Zou Z, Yang S, Ouyang J, Zeng W, Yang B, Xiao S, Huang L (2009) Distribution of Escherichia coli F4 adhesion phenotypes in pigs of 15 Chinese and Western breeds and a White Duroc\u00a0\u00d7\u00a0Erhualian intercross. J Med Microbiol 58:1112\u20131117. doi: 10.1099\/jmm.0.009803-0","journal-title":"J Med Microbiol"},{"issue":"s1","key":"268_CR24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1439-0388.2005.00490.x","volume":"122","author":"P Python","year":"2005","unstructured":"Python P, J\u00f6rg H, Neuenschwander S, Asai-Coakwell M, Hagger C, B\u00fcrgi E, Bertschinger HU, Stranzinger G, V\u00f6geli P (2005) Inheritance of the F4ab, F4ac and F4ad E. coli receptors in swine and examination of four candidate genes for F4acR. J Anim Breed Genet 122(s1):5\u201314. doi: 10.1111\/j.1439-0388.2005.00490.x","journal-title":"J Anim Breed Genet"},{"key":"268_CR25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2052.2007.01608.x","volume":"38","author":"QL Peng","year":"2007","unstructured":"Peng QL, Ren J, Yan XM, Huang X, Tang H, Wang YZ, Zhang B, Huang LS (2007) The g.243A\u00a0>\u00a0G mutation in intron 17 of MUC4 is significantly associated with susceptibility\/resistance to ETEC F4ab\/ac infections in pigs. Anim Genet 38:397\u2013400. doi: 10.1111\/j.1365-2052.2007.01608.x","journal-title":"Anim Genet"},{"key":"268_CR26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1439-0388.2007.00664.x","volume":"124","author":"YZ Wang","year":"2007","unstructured":"Wang YZ, Ren J, Lan LT, Yan XM, Huang X, Peng QL, Tang H, Zhang B, Ji HY, Huang LS (2007) Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab\/ac in pigs. J Anim Breed Genet 124:225\u2013229. doi: 10.1111\/j.1439-0388.2007.00664.x","journal-title":"J Anim Breed Genet"},{"key":"268_CR27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2052.1993.tb00347.x","volume":"24","author":"G Gu\u00e9rin","year":"1993","unstructured":"Gu\u00e9rin G, Duval-Iflah Y, Bonneau M, Bertaud M, Guillaume P, Ollivier L (1993) Evidence for linkage between K88ab, K88ac intestinal receptors to Escherichia coli and transferrin loci in pigs. Anim Genet 24:393\u2013396. doi: 10.1111\/j.1365-2052.1993.tb00347.x","journal-title":"Anim Genet"},{"key":"268_CR28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1673-8527(07)60067-8","volume":"34","author":"YH Li","year":"2007","unstructured":"Li YH, Qiu XT, Li HJ, Zhang Q (2007) Adhesive patterns of Escherichia coli F4 in piglets of three breeds. J Genet Genomics 34:591\u2013599. doi: 10.1016\/S1673-8527(07)60067-8","journal-title":"J Genet Genomics"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-010-0268-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-010-0268-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-010-0268-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T08:25:37Z","timestamp":1591950337000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-010-0268-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,2]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["268"],"URL":"https:\/\/doi.org\/10.1007\/s11033-010-0268-y","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,2]]}}}