{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:43:15Z","timestamp":1759815795650},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T00:00:00Z","timestamp":1300838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s11033-010-0390-x","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T07:43:21Z","timestamp":1300779801000},"page":"3277-3284","source":"Crossref","is-referenced-by-count":16,"title":["Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension"],"prefix":"10.1007","volume":"38","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-tang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-peng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,3,23]]},"reference":[{"key":"390_CR1","first-page":"1076","volume":"59","author":"Y Tanino","year":"2001","unstructured":"Tanino Y (2001) Monocrotaline-induced pulmonary hypertension in animals. Nippon Rinsho 59:1076\u20131080","journal-title":"Nippon Rinsho"},{"key":"390_CR2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1378\/chest.06-2243","volume":"132","author":"H Sawada","year":"2007","unstructured":"Sawada H, Mitani Y, Maruyama J, Jiang BH, Ikeyama Y, Dida FA, Yamamoto H, Imanaka-Yoshida K, Shimpo H, Mizoguchi A, Maruyama K, Komada Y (2007) A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats. Chest 132:1265\u20131274","journal-title":"Chest"},{"key":"390_CR3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1183\/09031936.03.00038903","volume":"22","author":"P Dorfm\u00fcller","year":"2003","unstructured":"Dorfm\u00fcller P, Perros F, Balabanian K, Humbert M (2003) Inflammation in pulmonary arterial hypertension. Eur Respir J 22:358\u2013363","journal-title":"Eur Respir J"},{"key":"390_CR4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1183\/09031936.05.00045705","volume":"26","author":"MR Nicolls","year":"2005","unstructured":"Nicolls MR, Taraseviciene-Stewart L, Rai PR, Badesch DB, Voelkel NF (2005) Autoimmunity and pulmonary hypertension. Eur Respir J 26:1110\u20131118","journal-title":"Eur Respir J"},{"key":"390_CR5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/01.aids.0000327509.30385.3b","volume":"22","author":"MM Lederman","year":"2008","unstructured":"Lederman MM, Sereni D, Simonneau G, Voelkel NF (2008) Pulmonary arterial hypertension and its association with HIV infection: an overview. AIDS 22:S1\u2013S6","journal-title":"AIDS"},{"key":"390_CR6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yjmcc.2007.09.006","volume":"44","author":"SY Chan","year":"2008","unstructured":"Chan SY, Loscalzo J (2008) Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol 44:14\u201330","journal-title":"J Mol Cell Cardiol"},{"key":"390_CR7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0272-5231(05)70280-X","volume":"22","author":"RM Tuder","year":"2001","unstructured":"Tuder RM, Cool CD, Yeager M, Taraseviciene-Stewart L, Bull TM, Voelkel NF (2001) The pathobiology of pulmonary hypertension. Endothelium. Clin Chest Med 22:405\u2013418","journal-title":"Clin Chest Med"},{"key":"390_CR8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.CIR.0000102381.57477.50","volume":"109","author":"R Budhiraja","year":"2004","unstructured":"Budhiraja R, Tuder RM, Hassoun PM (2004) Endothelial dysfunction in pulmonary hypertension. Circulation 109:159\u2013165","journal-title":"Circulation"},{"key":"390_CR9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1164\/rccm.200810-1662OC","volume":"180","author":"M Toshner","year":"2009","unstructured":"Toshner M, Voswinckel R, Southwood M, Al-Lamki R, Howard LS, Marchesan D, Yang J, Suntharalingam J, Soon E, Exley A, Stewart S, Hecker M, Zhu Z, Gehling U, Seeger W, Pepke-Zaba J, Morrell NW (2009) Evidence for dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med 180:780\u2013787","journal-title":"Am J Respir Crit Care Med"},{"key":"390_CR10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/1521-4141(200001)30:1<87::AID-IMMU87>3.0.CO;2-7","volume":"30","author":"A Foussat","year":"2000","unstructured":"Foussat A, Coulomb-L\u2019Hermine A, Gosling J, Krzysiek R, Durand-Gasselin I, Schall T, Balian A, Richard Y, Galanaud P, Emilie D (2000) Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human. Eur J Immunol 30:87\u201397","journal-title":"Eur J Immunol"},{"key":"390_CR11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/385640a0","volume":"385","author":"JF Bazan","year":"1997","unstructured":"Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ (1997) A new class of membrane bound chemokine with a CX3C motif. Nature 385:640\u2013644","journal-title":"Nature"},{"key":"390_CR12","first-page":"275","volume":"144","author":"RM Tuder","year":"1994","unstructured":"Tuder RM, Groves B, Badesch DB, Voelkel NF (1994) Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 144:275\u2013285","journal-title":"Am J Pathol"},{"key":"390_CR13","doi-asserted-by":"crossref","first-page":"571S","DOI":"10.1378\/chest.128.6_suppl.571S-a","volume":"128","author":"L Taraseviciene-Stewart","year":"2005","unstructured":"Taraseviciene-Stewart L, Scerbavicius DK, Burns N, Cool CD, Nicolls MR, Voelkel NF (2005) The protective role of T-lymphocytes in pulmonary vascular remodeling. Chest 128:571S\u2013572S","journal-title":"Chest"},{"key":"390_CR14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1600-065X.1982.tb00431.x","volume":"65","author":"TR Cupps","year":"1982","unstructured":"Cupps TR, Fauci AS (1982) Corticosteroid-mediated immunoregulation in man. Immunol Rev 65:133\u2013155","journal-title":"Immunol Rev"},{"key":"390_CR15","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.4049\/jimmunol.156.7.2406","volume":"156","author":"F Ram\u00edrez","year":"1996","unstructured":"Ram\u00edrez F, Fowell DJ, Puklavec M, Simmonds S, Mason D (1996) Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol 156:2406\u20132412","journal-title":"J Immunol"},{"key":"390_CR16","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.4049\/jimmunol.160.5.2231","volume":"160","author":"RH DeKruyff","year":"1998","unstructured":"DeKruyff RH, Fang Y, Umetsu DT (1998) Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol 160:2231\u20132237","journal-title":"J Immunol"},{"key":"390_CR17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10875-007-9111-1","volume":"27","author":"C Guo","year":"2007","unstructured":"Guo C, Chu X, Shi Y, He W, Li L, Wang L, Wang Y, Peng J, Hou M (2007) Correction of Th1-dominant cytokine profiles by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. J Clin Immunol 27:557\u2013562","journal-title":"J Clin Immunol"},{"key":"390_CR18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0167-5699(97)80019-9","volume":"18","author":"S Romagnani","year":"1997","unstructured":"Romagnani S (1997) The Thl\/Th2 paradigm. Immunol Today 18:263\u2013266","journal-title":"Immunol Today"},{"key":"390_CR19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/thx.54.3.273","volume":"54","author":"O Sanchez","year":"1999","unstructured":"Sanchez O, Humbert M, Sitbon O, Simonneau G (1999) Treatment of pulmonary hypertension secondary to connective tissue diseases. Thorax 54:273\u2013277","journal-title":"Thorax"},{"key":"390_CR20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/thx.54.4.372","volume":"54","author":"F Bellotto","year":"1999","unstructured":"Bellotto F, Chiavacci P, Laveder F, Angelini A, Thiene G, Marcolongo R (1999) Effective immunosuppressive therapy in a patient with primary pulmonary hypertension. Thorax 54:372\u2013374","journal-title":"Thorax"},{"key":"390_CR21","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/01.CIR.100.12.1330","volume":"100","author":"SF Liu","year":"1999","unstructured":"Liu SF, Ye X, Malik AB (1999) Inhibition of NF-kB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation 100:1330\u20131337","journal-title":"Circulation"},{"key":"390_CR22","doi-asserted-by":"crossref","first-page":"L1250","DOI":"10.1152\/ajplung.00069.2007","volume":"294","author":"J Huang","year":"2008","unstructured":"Huang J, Kaminski PM, Edwards JG, Yeh A, Wolin MS, Frishman WH, Gewitz MH, Mathew R (2008) Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension. Am J Physiol Lung Cell Mol Physiol 294:L1250\u2013L1259","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"390_CR23","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","volume":"18","author":"HL Pahl","year":"1999","unstructured":"Pahl HL (1999) Activators and target genes of Rel\/NF-kappaB transcription factors. Oncogene 18:6853\u20136866","journal-title":"Oncogene"},{"key":"390_CR24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11033-007-9084-4","volume":"35","author":"UJ Lee","year":"2008","unstructured":"Lee UJ, Choung SR, Prakash KV, Lee EJ, Lee MY, Kim YJ, Han CW, Choi YC (2008) Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha. Mol Biol Rep 35:291\u2013298","journal-title":"Mol Biol Rep"},{"key":"390_CR25","doi-asserted-by":"crossref","first-page":"31868","DOI":"10.1074\/jbc.274.45.31868","volume":"274","author":"AJ Schottelius","year":"1999","unstructured":"Schottelius AJ, Mayo MW, Sartor RB, Baldwin AS Jr (1999) Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J Biol Chem 274:31868\u201331874","journal-title":"J Biol Chem"},{"key":"390_CR26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.270.5234.283","volume":"270","author":"RI Scheinman","year":"1995","unstructured":"Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr (1995) Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270:283\u2013286","journal-title":"Science"},{"key":"390_CR27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1476-5381.1984.tb10772.x","volume":"82","author":"KS Hilliker","year":"1984","unstructured":"Hilliker KS, Roth RA (1984) Alteration of monocrotaline pyrrole-induced cardiopulmonary effects in rats by hydrallazine, dexamethasone or sulphinpyrazone. Br J Pharmacol 82:375\u2013380","journal-title":"Br J Pharmacol"},{"key":"390_CR28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1084\/jem.20071008","volume":"205","author":"E Daley","year":"2008","unstructured":"Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G (2008) Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 205:361\u2013372","journal-title":"J Exp Med"},{"key":"390_CR29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0167-5699(97)01111-0","volume":"18","author":"T Wilckens","year":"1997","unstructured":"Wilckens T, De Rijk R (1997) Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol Today 18:418\u2013424","journal-title":"Immunol Today"},{"key":"390_CR30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.carpath.2004.06.003","volume":"13","author":"RF Pinto","year":"2004","unstructured":"Pinto RF, Higuchi Mde L, Aiello VD (2004) Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts. Cardiovasc Pathol 13:268\u2013275","journal-title":"Cardiovasc Pathol"},{"key":"390_CR31","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","volume":"133","author":"S Sakaguchi","year":"2008","unstructured":"Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775\u2013787","journal-title":"Cell"},{"key":"390_CR32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1189\/jlb.0105007","volume":"78","author":"U Kumaraguru","year":"2005","unstructured":"Kumaraguru U, Banerjee K, Rouse BT (2005) In vivo rescue of defective memory CD8+ T cells by cognate helper T cells. J Leukoc Biol 78:879\u2013887","journal-title":"J Leukoc Biol"},{"key":"390_CR33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.clim.2006.02.002","volume":"119","author":"P Trzonkowski","year":"2006","unstructured":"Trzonkowski P, Szmit E, My\u015bliwska J, My\u015bliwski A (2006) CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans impact of immunosenescence. Clin Immunol 119:307\u2013316","journal-title":"Clin Immunol"},{"key":"390_CR34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5551\/jat.11.15","volume":"11","author":"T Imaizumi","year":"2004","unstructured":"Imaizumi T, Yoshida H, Satoh K (2004) Regulation of CX3CL1\/fractalkine expression in endothelial cells. J Atheroscler Thromb 11:15\u201321","journal-title":"J Atheroscler Thromb"},{"key":"390_CR35","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1183\/09031936.00104706","volume":"29","author":"F Perros","year":"2007","unstructured":"Perros F, Dorfm\u00fcller P, Souza R, Durand-Gasselin I, Godot V, Capel F, Adnot S, Eddahibi S, Mazmanian M, Fadel E, Herv\u00e9 P, Simonneau G, Emilie D, Humbert M (2007) Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Eur Respir J 29:937\u2013943","journal-title":"Eur Respir J"},{"key":"390_CR36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","volume":"91","author":"T Imai","year":"1997","unstructured":"Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521\u2013530","journal-title":"Cell"},{"key":"390_CR37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1042\/bst0310060","volume":"31","author":"M Kagoshima","year":"2003","unstructured":"Kagoshima M, Ito K, Cosio B, Adcock IM (2003) Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. Biochem Soc Trans 31:60\u201365","journal-title":"Biochem Soc Trans"},{"key":"390_CR38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2004.07.011","volume":"500","author":"R Hayashi","year":"2004","unstructured":"Hayashi R, Wada H, Ito K, Adcock IM (2004) Effects of glucocorticoids on gene transcription. Eur J Pharmacol 500:51\u201362","journal-title":"Eur J Pharmacol"},{"key":"390_CR39","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1164\/ajrccm.162.6.2002018","volume":"162","author":"JL Faul","year":"2000","unstructured":"Faul JL, Nishimura T, Berry GJ, Benson GV, Pearl RG, Kao PN (2000) Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med 162:2252\u20132258","journal-title":"Am J Respir Crit Care Med"},{"key":"390_CR40","doi-asserted-by":"crossref","first-page":"13443","DOI":"10.1074\/jbc.274.19.13443","volume":"274","author":"D Qiu","year":"1999","unstructured":"Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC, Kao PN (1999) Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box\/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 274:13443\u201313450","journal-title":"J Biol Chem"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-010-0390-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-010-0390-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-010-0390-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T21:24:53Z","timestamp":1686000293000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-010-0390-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,23]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["390"],"URL":"https:\/\/doi.org\/10.1007\/s11033-010-0390-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,23]]}}}