{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:29:10Z","timestamp":1775305750626,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,6,5]],"date-time":"2011-06-05T00:00:00Z","timestamp":1307232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s11033-011-0935-7","type":"journal-article","created":{"date-parts":[[2011,6,4]],"date-time":"2011-06-04T07:08:35Z","timestamp":1307171315000},"page":"1895-1901","source":"Crossref","is-referenced-by-count":21,"title":["Impact of DNA repair genes polymorphism (XPD and XRCC1) on the risk of breast cancer in Egyptian female patients"],"prefix":"10.1007","volume":"39","author":[{"given":"Yousry Mostafa","family":"Hussien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal F.","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan A.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab A.","family":"Karam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael H.","family":"Elsawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,6,5]]},"reference":[{"key":"935_CR1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","volume":"55","author":"DM Parkin","year":"2005","unstructured":"Parkin DM, Bray F, Ferlay J (2005) Global cancer statistics. CA Cancer J Clin 55:74\u2013108","journal-title":"CA Cancer J Clin"},{"key":"935_CR2","volume-title":"Cancer profile in Gharbiah, Egypt: methodology and results","author":"AS Ibrahim","year":"2002","unstructured":"Ibrahim AS et al (2002) Cancer profile in Gharbiah, Egypt: methodology and results. Ministry of Health and Population Egypt and Middle East Cancer Consortium, Cairo"},{"key":"935_CR3","volume-title":"Cancer registration NCI, Egypt, Cairo","author":"I Elatar","year":"2001","unstructured":"Elatar I (2001) Cancer registration NCI, Egypt, Cairo. National Cancer Institute, Egypt"},{"issue":"3\u20134","key":"935_CR4","first-page":"329","volume":"77","author":"G Hosny","year":"2002","unstructured":"Hosny G, Elkaffas SM (2002) A prediction model for the incidence patterns of female breast cancers in Alexandria, Egypt. J Egypt Public Health Assoc 77(3\u20134):329\u2013345","journal-title":"J Egypt Public Health Assoc"},{"key":"935_CR5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/em.10058","volume":"39","author":"JJ Hu","year":"2002","unstructured":"Hu JJ, Smith TR, Miller MS, Lohman K, Case LD (2002) Genetic regulation of ionizing radiation sensitivity and breast cancer risk. Environ Mol Mutagen 39:208\u2013215","journal-title":"Environ Mol Mutagen"},{"issue":"1","key":"935_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1996.307","volume":"74","author":"R Parshad","year":"1996","unstructured":"Parshad R, Price FM, Bohr VA, Cowans KH, Zujewski JA, Sanford KK (1996) Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer 74(1):1\u20135","journal-title":"Br J Cancer"},{"key":"935_CR7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10549-005-9151-2","volume":"98","author":"T Debniak","year":"2006","unstructured":"Debniak T, Scott RJ, Huzarski T, Byrski T, Masojc B, van de Wetering T, Serrano-Fernandez P, Gorski B, Cybulski C, Gronwald J, Debniak B, Maleszka R, Kladny J, Bieniek A, Nagay L, Haus O, Grzybowska E, Wandzel P, Niepsuj S, Narod SA, Lubinski J (2006) XPD common variants and their association with melanoma and breast cancer risk. Breast Cancer Res Treat 98:209\u2013215","journal-title":"Breast Cancer Res Treat"},{"key":"935_CR8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0027-5107(02)00217-8","volume":"509","author":"JG Boer de","year":"2002","unstructured":"de Boer JG (2002) Polymorphisms in DNA repair and environmental interactions. Mutat Res 509:201\u2013210","journal-title":"Mutat Res"},{"key":"935_CR9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/jnci\/92.11.874","volume":"92","author":"M Berwick","year":"2000","unstructured":"Berwick M, Vineis P (2000) Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst 92:874\u2013897","journal-title":"J Natl Cancer Inst"},{"key":"935_CR10","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.dnarep.2007.02.010","volume":"6","author":"JP Laine","year":"2007","unstructured":"Laine JP, Mocquet V, Bonfanti M, Braun C, Egly JM, Brousset P (2007) Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription. DNA Repair (Amst) 6:1264\u20131270","journal-title":"DNA Repair (Amst)"},{"key":"935_CR11","first-page":"604","volume":"58","author":"MR Shen","year":"1998","unstructured":"Shen MR, Jones IM, Mohrenweiser H (1998) Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res 58:604\u2013608","journal-title":"Cancer Res"},{"key":"935_CR12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/carcin\/21.4.551","volume":"21","author":"RM Lunn","year":"2000","unstructured":"Lunn RM, Helzlsouer KJ, Parshad R, Umbach DM, Harris EL, Sanford KK, Bell DA (2000) XPD polymorphisms: effects on DNA repair proficiency. Carcinogenesis 21:551\u2013555","journal-title":"Carcinogenesis"},{"key":"935_CR13","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1093\/nar\/24.22.4387","volume":"24","author":"KW Caldecott","year":"1996","unstructured":"Caldecott KW, Aoufouchi S, Johnson P, Shall S (1996) XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular \u2018nick-sensor\u2019 in vitro. Nucleic Acids Res 24:4387\u20134394","journal-title":"Nucleic Acids Res"},{"key":"935_CR14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/taap.2002.9518","volume":"185","author":"JJ Hu","year":"2002","unstructured":"Hu JJ, Mohrenweiser HW, Bell DA (2002) Symposium overview: genetic polymorphisms in DNA repair and cancer risk. Toxicol Appl Pharmacol 185:64\u201373","journal-title":"Toxicol Appl Pharmacol"},{"key":"935_CR15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/bjc.1957.43","volume":"11","author":"HI Bloom","year":"1957","unstructured":"Bloom HI, Richardson WW (1957) Histological grading and prognosis. Br J Cancer 11:359\u2013377","journal-title":"Br J Cancer"},{"key":"935_CR16","unstructured":"Breast AJCC (2002) Cancer staging manual. In: American Joint Committee on Cancer, 6th ed. Springer, New York, pp 171\u2013180"},{"key":"935_CR17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1158\/1055-9965.EPI-03-0053","volume":"13","author":"BA Rybicki","year":"2004","unstructured":"Rybicki BA, Conti DV, Moreira A, Cicek M, Casey G, Witte JS (2004) Repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 13:23\u201329","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"8","key":"935_CR18","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/carcin\/bgh153","volume":"25","author":"H Ito","year":"2004","unstructured":"Ito H, Matsuo K, Hamajima N, Mitsudomi T (2004) Gene\u2013environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk. Carcinogenesis 25(8):1395\u20131401","journal-title":"Carcinogenesis"},{"key":"935_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.54.1.8","volume":"54","author":"A Jemal","year":"2004","unstructured":"Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ (2004) Cancer statistics. CA Cancer J Clin 54:8\u201329","journal-title":"CA Cancer J Clin"},{"key":"935_CR20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/jnci\/88.11.754","volume":"88","author":"KJ Helzlsouer","year":"1996","unstructured":"Helzlsouer KJ, Harris EL, Parshad R (1996) DNA repair proficiency: potential susceptibility factor for breast cancer. J Natl Cancer Inst 88:754\u2013755","journal-title":"J Natl Cancer Inst"},{"key":"935_CR21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3835(97)00419-9","volume":"124","author":"B Jyothish","year":"1998","unstructured":"Jyothish B, Ankathil R, Chandini R et al (1998) DNA repair proficiency: a potential marker for identification of high risk members in breast cancer families. Cancer Lett 124:9\u201313","journal-title":"Cancer Lett"},{"key":"935_CR22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/carcin\/22.9.1437","volume":"22","author":"G Matullo","year":"2001","unstructured":"Matullo G, Palli D, Peluso M et al (2001) XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. Carcinogenesis 22:1437\u20131445","journal-title":"Carcinogenesis"},{"key":"935_CR23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.dnarep.2005.07.001","volume":"4","author":"SG Clarkson","year":"2005","unstructured":"Clarkson SG, Wood RD (2005) Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: an appraisal. DNA Repair (Amst) 4:1068\u20131074","journal-title":"DNA Repair (Amst)"},{"key":"935_CR24","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1158\/0008-5472.CAN-05-3388","volume":"66","author":"BF Pachkowski","year":"2006","unstructured":"Pachkowski BF, Winkel S, Kubota Y et al (2006) XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. Cancer Res 66:2860\u20132868","journal-title":"Cancer Res"},{"key":"935_CR25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cccn.2005.03.047","volume":"359","author":"L Zhang","year":"2005","unstructured":"Zhang L, Zhang Z, Yan W (2005) Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta 359:150\u2013155","journal-title":"Clin Chim Acta"},{"key":"935_CR26","doi-asserted-by":"crossref","unstructured":"Wang HC, Liu CS, Wang HC, Tsai RY, Tsai CW, Wang RF, Chen YS, Chiu CF, Bau DT, Huang CY (2010) Significant association of XPD Asp312Asn polymorphism with breast cancer in Taiwanese patients. Chin J Physiol 53 (prepublication ahead of print)","DOI":"10.4077\/CJP.2010.AMK005"},{"key":"935_CR27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-4598-7-36","volume":"7","author":"D Bernard-Gallon","year":"2008","unstructured":"Bernard-Gallon D, Bosviel R, Delort L, Fontana L, Chamoux A, Rabiau N, Kwiatkowski F, Chalabi N, Satih S, Bignon YJ (2008) DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk. Mol Cancer 7:36","journal-title":"Mol Cancer"},{"key":"935_CR28","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1158\/1055-9965.EPI-04-0807","volume":"14","author":"B Kuschel","year":"2005","unstructured":"Kuschel B, Chenevix-Trench G, Spurdle AB, Chen X, Hopper JL, Giles GG, McCredie M, Chang-Claude J, Gregory CS, Day NE, Easton DF, Ponder BA, Dunning AM, Pharoah PD (2005) Common polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev 14:1828\u20131831","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"935_CR29","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1093\/carcin\/bgn193","volume":"29","author":"TR Smith","year":"2008","unstructured":"Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, Liu-Mares W, Hu JJ (2008) Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis 29:2132\u20132138","journal-title":"Carcinogenesis"},{"key":"935_CR30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1158\/1055-9965.583.13.4","volume":"13","author":"JC Figueiredo","year":"2004","unstructured":"Figueiredo JC, Knight JA, Briollais L et al (2004) Polymorphisms XRCC1\u2013R399Q and XRCC3\u2013T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 13:583\u2013591","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"935_CR31","first-page":"1462","volume":"12","author":"XO Shu","year":"2003","unstructured":"Shu XO, Cai Q, Gao YT et al (2003) A population-based case control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 12:1462\u20131467","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"935_CR32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-3835(02)00595-5","volume":"190","author":"TR Smith","year":"2003","unstructured":"Smith TR, Miller MS, Lohman K et al (2003) Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett 190:183\u2013190","journal-title":"Cancer Lett"},{"key":"935_CR33","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/emm.2004.73","volume":"36","author":"U Deligezer","year":"2004","unstructured":"Deligezer U, Dalay N (2004) Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. Exp Mol Med 36:572\u2013575","journal-title":"Exp Mol Med"},{"key":"935_CR34","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1158\/1055-9965.EPI-04-0414","volume":"14","author":"J Shen","year":"2005","unstructured":"Shen J, Gammon MD, Terry MB et al (2005) Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 14:336\u2013342","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"935_CR35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10549-004-1004-x","volume":"89","author":"P Chacko","year":"2005","unstructured":"Chacko P, Rajan B, Joseph T et al (2005) Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer. Breast Cancer Res Treat 89:15\u201321","journal-title":"Breast Cancer Res Treat"},{"key":"935_CR36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12253-008-9135-8","volume":"15","author":"VS Syamala","year":"2009","unstructured":"Syamala VS, Syamala V, Sreedharan H, Raveendran PB, Kuttan R, Ankathil R (2009) Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) polymorphisms in familial and sporadic breast cancer predisposition and survival: an Indian report. Pathol Oncol Res 15:389\u2013397","journal-title":"Pathol Oncol Res"},{"key":"935_CR37","first-page":"217","volume":"10","author":"EJ Duell","year":"2001","unstructured":"Duell EJ, Millikan RC, Pittman GS et al (2001) Polymorphisms in the DNA repair gene XRCC1 and breast cancer. Cancer Epidemiol Biomarkers Prev 10:217\u2013222","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"935_CR38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00008571-200206000-00010","volume":"12","author":"SU Kim","year":"2002","unstructured":"Kim SU, Park SK, Yoo KY et al (2002) XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics 12:335\u2013338","journal-title":"Pharmacogenetics"},{"key":"935_CR39","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.dnarep.2005.07.001","volume":"4","author":"SG Clarkson","year":"2005","unstructured":"Clarkson SG, Wood RD (2005) Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: an appraisal. DNA Repair (Amst) 4:1068\u20131074","journal-title":"DNA Repair (Amst)"},{"key":"935_CR40","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1568-7864(03)00085-5","volume":"2","author":"Y Wang","year":"2003","unstructured":"Wang Y, Spitz MR, Zhu Y et al (2003) From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. DNA Repair (Amst) 2:901\u2013908","journal-title":"DNA Repair (Amst)"},{"key":"935_CR41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/1477-3163.62535","volume":"9","author":"J Zipprich","year":"2010","unstructured":"Zipprich J, Terry MB, Brandt-Rauf P, Freyer GA, Liao Y, Agrawal M, Gurvich I, Senie R, Santella RM (2010) XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: a family-based case-control study. J Carcinog 9:4","journal-title":"J Carcinog"},{"key":"935_CR42","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/carcin\/22.9.1437","volume":"22","author":"G Matullo","year":"2001","unstructured":"Matullo G, Palli D, Peluso M et al (2001) XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. Carcinogenesis 22:1437\u20131445","journal-title":"Carcinogenesis"},{"key":"935_CR43","first-page":"2557","volume":"59","author":"RM Lunn","year":"1999","unstructured":"Lunn RM, Langlois RG, Hsieh LL et al (1999) XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res 59:2557\u20132561","journal-title":"Cancer Res"},{"key":"935_CR44","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/carcin\/22.6.917","volume":"22","author":"JJ Hu","year":"2001","unstructured":"Hu JJ, Smith TR, Miller MS et al (2001) Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis 22:917\u2013922","journal-title":"Carcinogenesis"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-011-0935-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-011-0935-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-011-0935-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:17:48Z","timestamp":1686118668000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-011-0935-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,5]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["935"],"URL":"https:\/\/doi.org\/10.1007\/s11033-011-0935-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,5]]}}}