{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:45:51Z","timestamp":1770911151887,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s11033-011-1285-1","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T14:11:09Z","timestamp":1322835069000},"page":"4899-4907","source":"Crossref","is-referenced-by-count":24,"title":["Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent"],"prefix":"10.1007","volume":"39","author":[{"given":"Rita de C\u00e1ssia","family":"Carvalho Barbosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Costa","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Fernando Vasconcelos","family":"Freire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo Campos","family":"Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Hugo Medeiros","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Helena Barem","family":"Rabenhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"key":"1285_CR1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","volume":"2","author":"DM Parkin","year":"2001","unstructured":"Parkin DM (2001) Global cancer statistics in the year 2000. Lancet Oncol 2:533\u2013543","journal-title":"Lancet Oncol"},{"key":"1285_CR2","unstructured":"Ferlay J, Bray F, Pisani P, Parkin DM (2004) Cancer incidence, mortality and prevalence worldwide IARC Cancer Base No 5, version 2.0"},{"key":"1285_CR3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/bcr921","volume":"6","author":"SE Hankinson","year":"2004","unstructured":"Hankinson SE, Colditz GA, Willett WC (2004) Towards an integrated mod breast cancer etiology. The lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res 6:213\u2013218","journal-title":"Breast Cancer Res"},{"key":"1285_CR4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1582-4934.2005.tb00350.x","volume":"9","author":"RG Dumitrescu","year":"2005","unstructured":"Dumitrescu RG, Cotarla I (2005) Understanding breast cancer risk\u2014where do we stand in 2005. J Cell Mol Med 9:208\u2013221","journal-title":"J Cell Mol Med"},{"key":"1285_CR5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0959-8049(00)00082-4","volume":"36","author":"BL Weber","year":"2000","unstructured":"Weber BL, Nathanson KL (2000) Low penetrance genes associated with increased risk for breast cancer. Eur J Cancer 36:1193\u20131199","journal-title":"Eur J Cancer"},{"key":"1285_CR6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/35077207","volume":"411","author":"BA Ponder","year":"2001","unstructured":"Ponder BA (2001) Cancer genetics. Nature 411:336\u2013341","journal-title":"Nature"},{"key":"1285_CR7","first-page":"917","volume":"11","author":"A Forsti","year":"2004","unstructured":"Forsti A, Angelini S, Festa F et al (2004) Single nucleotide polymorphisms in breast cancer. Oncol Rep 11:917\u2013922","journal-title":"Oncol Rep"},{"key":"1285_CR8","first-page":"20","volume":"13","author":"M F\u00f6dinger","year":"2000","unstructured":"F\u00f6dinger M, H\u00f6rl WH, Sunder-Plassmann G (2000) Molecular biology of 5,10-methylenetetrahydrofolate reductase. Nephrol 13:20\u201333","journal-title":"Nephrol"},{"key":"1285_CR9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/130.2.129","volume":"130","author":"SW Choi","year":"2000","unstructured":"Choi SW, Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130:129\u2013132","journal-title":"J Nutr"},{"key":"1285_CR10","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/jn\/130.9.2238","volume":"130","author":"LL Stern","year":"2000","unstructured":"Stern LL, Bagley PJ, Rosenberg IH, Selhub J (2000) Conversion of 5-formyltetrahydrofolic acid to 5-methyltetrahydrofolic acid is unimpaired in folate-adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene. J Nutr 130:2238\u20132242","journal-title":"J Nutr"},{"key":"1285_CR11","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1182\/blood.V99.10.3786","volume":"99","author":"CF Skibola","year":"2002","unstructured":"Skibola CF, Smith MT, Hubbard A, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ (2002) Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 99:3786\u20133791","journal-title":"Blood"},{"key":"1285_CR12","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/art.20460","volume":"50","author":"T Dervieux","year":"2004","unstructured":"Dervieux T, Furst D, Lein DO et al (2004) Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 50:2766\u20132774","journal-title":"Arthritis Rheum"},{"key":"1285_CR13","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuron.2008.01.002","volume":"57","author":"L Luo","year":"2008","unstructured":"Luo L, Callaway EM, Svoboda K (2008) Genetic dissection of neural circuits. Neuron 57:634\u2013660","journal-title":"Neuron"},{"key":"1285_CR14","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00228-005-0054-2","volume":"61","author":"HS S\u00fczen","year":"2005","unstructured":"S\u00fczen HS, Y\u00fcce N, G\u00fcven\u00e7 G, Duydu Y, Erke T (2005) TYMS and DPYD polymorphisms in a Turkish population. Eur J Clin Pharmacol 61:881\u2013885","journal-title":"Eur J Clin Pharmacol"},{"key":"1285_CR15","first-page":"889","volume":"19","author":"U Deligezer","year":"2005","unstructured":"Deligezer U, Akisik EE, Dalay N (2005) Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. In Vivo 19:889\u2013893","journal-title":"In Vivo"},{"key":"1285_CR16","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1158\/1055-9965.EPI-05-0592","volume":"14","author":"C Justenhoven","year":"2005","unstructured":"Justenhoven C, Hamann U, Pierl CB, Rabstein S, Pesch B, Harth V, Baisch C, Vollmert C, Illig T, Br\u00fcning T, Ko Y, Brauch H (2005) One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany. Cancer Epidemiol Biomark Prev 14:3015\u20133018","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000076460","volume":"24","author":"E Ergul","year":"2003","unstructured":"Ergul E, Sazci A, Utkan Z, Canturk NZ (2003) Polymorphisms in the MTHFR gene are associated with breast cancer. Tumour Biol 24:286\u2013290","journal-title":"Tumour Biol"},{"key":"1285_CR18","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1158\/0008-5472.CAN-04-2630","volume":"65","author":"J Chen","year":"2005","unstructured":"Chen J, Gammon MD, Chan W, Palomeque C, Wetmur JG, Kabat GC, Teitelbaum SL, Britton JA, Terry MB, Neugut AI, Santella RM (2005) One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 65:1606\u20131614","journal-title":"Cancer Res"},{"key":"1285_CR19","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1158\/1055-9965.EPI-09-0159","volume":"18","author":"ME Platek","year":"2009","unstructured":"Platek ME, Shields PG, Marian C, McCann SE, Bonner MR, Nie J, Ambrosone CB, Millen AE, Ochs-Balcom HM, Quick SK et al (2009) Alcohol consumption and genetic variation in Methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol Biomark Prev 18:2453\u20132459","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1158\/1055-9965.EPI-06-1037","volume":"16","author":"VL Stevens","year":"2007","unstructured":"Stevens VL, McCullough ML, Pavluck AL, Talbot JT, Feigelson HS, Thun MJ, Calle EE (2007) Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. Cancer Epidemiol Biomark Prev 16:1140\u20131147","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR21","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/carcin\/bgl108","volume":"27","author":"YC Chou","year":"2006","unstructured":"Chou YC, Wu MH, Yu JC, Lee MS, Yang T, Shih HL, Wu TY, Sun CA (2006) Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case\u2013control study in Taiwan. Carcinogenesis 27:2295\u20132300","journal-title":"Carcinogenesis"},{"key":"1285_CR22","first-page":"1727","volume":"27","author":"CP Yu","year":"2007","unstructured":"Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, Sun CA (2007) Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case\u2013control study in Taiwan. Anticancer Res 27:1727\u20131732","journal-title":"Anticancer Res"},{"key":"1285_CR23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-2407-9-122","volume":"9","author":"E Ma","year":"2009","unstructured":"Ma E, Iwasaki M, Junko I, Hamada GS, Nishimoto IN, Carvalho SM, Motola J Jr, Laginha FM, Tsugane S (2009) Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case\u2013control study in Brazilian women. BMC Cancer 9:122","journal-title":"BMC Cancer"},{"key":"1285_CR24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1158\/1055-9965.EPI-05-0576","volume":"15","author":"MJ Shrubsole","year":"2006","unstructured":"Shrubsole MJ, Gao YT, Cai QY, Shu XO, Dai Q, Jin F, Zheng W (2006) MTR and MTRR polymorphisms, dietary intake, and breast cancer risk. Cancer Epidemiol Biomark Prev 15:586\u2013588","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10549-008-9895-6","volume":"112","author":"J Kotsopoulos","year":"2008","unstructured":"Kotsopoulos J, Zhang WW, Zhang S, McCready D, Trudeau M, Zhang P, Sun P, Narod SA (2008) Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res Treat 112:585\u2013593","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10549-007-9754-x","volume":"111","author":"CW Cheng","year":"2008","unstructured":"Cheng CW, Yu JC, Huang CS, Shieh JC, Fu YP, Wang HW, Wu PE, Shen CY (2008) Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat 111:145\u2013155","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ejcn.2009.104","volume":"64","author":"AR Bentley","year":"2010","unstructured":"Bentley AR, Raiszadeh F, Stover PJ, Hunter DJ, Hankinson SE, Cassano PA (2010) No association between cSHMT genotypes and the risk of breast cancer in the Nurses\u2019 Health Study. Short communication. Eur J Clin Nutr 64:108\u2013110","journal-title":"Eur J Clin Nutr"},{"key":"1285_CR28","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1158\/1055-9965.EPI-07-2900","volume":"17","author":"X Xu","year":"2008","unstructured":"Xu X, Gammon MD, Wetmur JG, Bradshaw PT, Teitelbaum SL, Neugut AI, Santella RM, Chen J (2008) B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer. Cancer Epidemiol Biomark Prev 17:2109\u20132116","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/bcr457","volume":"4","author":"IG Campbell","year":"2002","unstructured":"Campbell IG, Baxter SW, Eccles DM, Choong DYH (2002) Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res 4:1\u20134","journal-title":"Breast Cancer Res"},{"key":"1285_CR30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1021843019755","volume":"77","author":"JC Semenza","year":"2003","unstructured":"Semenza JC, Delfino RJ, Ziogas A, Anton-Culver H (2003) Breast cancer risk and methylenetetrahydrofolate reductase polymorphism. Breast Cancer Res Treat 77:217\u2013223","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR31","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/carcin\/bgm295","volume":"29","author":"T Suzuki","year":"2008","unstructured":"Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, Iwata H, Tajima K (2008) One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 29:356\u2013362","journal-title":"Carcinogenesis"},{"key":"1285_CR32","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1158\/1055-9965.EPI-08-0401","volume":"18","author":"U Ericson","year":"2009","unstructured":"Ericson U, Sonestedt E, Ivarsson MI, Gullberg B, Carlson J, Olsson H, Wirfalt E (2009) Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmo diet and cancer cohort. Cancer Epidemiol Biomark Prev 18:1101\u20131110","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR33","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1186\/bcr2462","volume":"11","author":"SS Maruti","year":"2009","unstructured":"Maruti SS, Ulrich CM, Jupe ER et al (2009) MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case\u2013control study. Breast Cancer Res 11:R91","journal-title":"Breast Cancer Res"},{"key":"1285_CR34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215","journal-title":"Nucleic Acids Res"},{"key":"1285_CR35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111\u2013113","journal-title":"Nat Genet"},{"key":"1285_CR36","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1158\/1055-9965.1331.13.8","volume":"13","author":"M Cicek","year":"2004","unstructured":"Cicek M, Nock N, Li L, Conti D, Casey G, Witte J (2004) Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness. Cancer Epidemiol Biomark Prevent 13:1331\u20131336","journal-title":"Cancer Epidemiol Biomark Prevent"},{"key":"1285_CR37","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1200\/JCO.2002.09.091","volume":"20","author":"MC Etienne","year":"2002","unstructured":"Etienne MC, Chazal M, Laurent-Puig P et al (2002) Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses. J Clin Oncol 20:2832\u20132843","journal-title":"J Clin Oncol"},{"key":"1285_CR38","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/sj.bjc.6601523","volume":"90","author":"MC Etienne","year":"2004","unstructured":"Etienne MC, Ilc K, Formento JL, Laurent-Puig P, Formento P, Cheradame S, Fischel JL, Milano G (2004) Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer 90:526\u2013534","journal-title":"Br J Cancer"},{"key":"1285_CR39","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1182\/blood.V97.10.3205","volume":"15","author":"K Matsuo","year":"2001","unstructured":"Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, Kondoh E, Maeda S, Asakura S, Kaba S, Nakamura S, Seto M, Morishima Y, Tajima K (2001) Association between polymorphisms of folate and methionine metabolizing enzymes and susceptibility to malignant lymphoma. Blood 15:3205\u20133209","journal-title":"Blood"},{"key":"1285_CR40","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1006\/mgme.2001.3175","volume":"73","author":"SG Heil","year":"2001","unstructured":"Heil SG et al (2001) Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab 73:164\u2013172","journal-title":"Mol Genet Metab"},{"key":"1285_CR41","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1046\/j.1523-1755.2003.00025.x","volume":"63","author":"WC Winkelmayer","year":"2003","unstructured":"Winkelmayer WC, Eberle C, Sunder-Plassmann G, Fodinger M (2003) Effects of the glutamate carboxypeptidase II (GCP2 1561CNT) and reduced folate carrier (RFC1 80GA) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 63:2280\u20132285","journal-title":"Kidney Int"},{"key":"1285_CR42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(98)05352-5","volume":"353","author":"GA Greendale","year":"1999","unstructured":"Greendale GA, Lee NP, Arriola ER (1999) The menopause. Lancet 353:571\u2013580","journal-title":"Lancet"},{"key":"1285_CR43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1471-2407-6-138","volume":"6","author":"X Zhai","year":"2006","unstructured":"Zhai X et al (2006) Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case\u2013control analysis. BMC Cancer 6:138","journal-title":"BMC Cancer"},{"key":"1285_CR44","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/1055-9965.EPI-03-0273","volume":"13","author":"MJ Shrubsole","year":"2004","unstructured":"Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, H\u00e9bert JR, Jin F, Zheng W (2004) MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomark Prev 13:190\u2013196","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1285_CR45","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/jnci\/djj440","volume":"98","author":"SJ Lewis","year":"2006","unstructured":"Lewis SJ, Harbord RM, Harris R, Smith GD (2006) Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J Natl Cancer Inst 98:1607\u20131622","journal-title":"J Natl Cancer Inst"},{"key":"1285_CR46","first-page":"3215","volume":"24","author":"F Grieu","year":"2004","unstructured":"Grieu F, Powell B, Beilby J, Iacopetta B (2004) Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. Anticancer Res 24:3215\u20133220","journal-title":"Anticancer Res"},{"key":"1285_CR47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10549-006-9491-6","volume":"106","author":"D Macis","year":"2007","unstructured":"Macis D, Maisonneuve P, Johansson H, Bonanni B, Botteri E, Iodice S, Santillo B, Penco S, Gucciardo G, D\u2019Aiuto G, Rosselli Del Turco M, Amadori M, Costa A, Decensi A (2007) Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-casecontrol study and a pooled meta-analysis. Breast Cancer Res Treat 106:263\u2013271","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR48","doi-asserted-by":"crossref","unstructured":"Henriquez-Hern\u00e1ndez LA, Murias-Rosales A, Hernandez Gonzalez A, Cabrera De Leon A, Diaz-Chico BN, Mori De Santiago M, Fernandez Perez L (2009) Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study. Oncol Rep 22:1425\u20131433","DOI":"10.3892\/or_00000584"},{"key":"1285_CR49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-010-0670-8","volume":"349","author":"NS Mohammad","year":"2011","unstructured":"Mohammad NS, Yedluri R, Addepalli P, Gottumukkala SR, Digumarti RR, Kutala VK (2011) Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Mol Cell Biochem 349:159\u2013167","journal-title":"Mol Cell Biochem"},{"key":"1285_CR50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10549-010-0755-9","volume":"123","author":"M Lu","year":"2010","unstructured":"Lu M, Wang F, Qiu J (2010) Methionine synthase A2756G polymorphism and breast cancer risk: a meta-analysis involving 18,953 subjects. Breast Cancer Res Treat 123:213\u2013217","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.leukres.2007.06.001","volume":"32","author":"CS Lima","year":"2008","unstructured":"Lima CS, Ortega MM, Ozelo MC, Araujo RC, De Souza CA, Lorand-Metze I, Annichino-Bizzacchi JM, Costa FF (2008) Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk. Leuk Res 32:401\u2013405","journal-title":"Leuk Res"},{"key":"1285_CR52","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1399-0004.1998.tb04286.x","volume":"54","author":"VR Arruda","year":"1998","unstructured":"Arruda VR, Grignolli CE, Goncalves MS, Soares MC, Menezes R, Saad STO, Costa FF (1998) Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clin Genet 54:210\u2013214","journal-title":"Clin Genet"},{"key":"1285_CR53","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10549-010-0773-7","volume":"123","author":"X Qi","year":"2010","unstructured":"Qi X, Ma X, Yang X, Fan L, Zhang Y, Zhang F, Chen L, Zhou Y, Jiang J (2010) Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls. Breast Cancer Res Treat 123:499\u2013506","journal-title":"Breast Cancer Res Treat"},{"key":"1285_CR54","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1016\/j.lfs.2005.02.029","volume":"77","author":"Z Yates","year":"2005","unstructured":"Yates Z, Lucock M (2005) G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism. Life Sci 77:2735\u20132742","journal-title":"Life Sci"},{"key":"1285_CR55","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/mgme.2000.3034","volume":"70","author":"A Chango","year":"2000","unstructured":"Chango A, Emery-Fillon N, de Courcy GP, Lambert D, Pfister M, Rosenblatt DS, Nicolas JP (2000) A polymorphism (80G-A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab 70:310\u2013315","journal-title":"Mol Genet Metab"},{"key":"1285_CR56","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1753-4887.2006.tb00178.x","volume":"64","author":"YI Kim","year":"2006","unstructured":"Kim YI (2006) Does a high folate intake increase the risk of breast cancer? Nutr Rev 64:468\u2013475","journal-title":"Nutr Rev"},{"key":"1285_CR57","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ajcn\/87.3.734","volume":"87","author":"J Lin","year":"2008","unstructured":"Lin J, Lee IM, Cook NR, Selhub J, Manson JE, Buring JE, Zhang SM (2008) Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr 87:734\u2013743","journal-title":"Am J Clin Nutr"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-011-1285-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-011-1285-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-011-1285-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T05:43:18Z","timestamp":1713159798000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-011-1285-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,2]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["1285"],"URL":"https:\/\/doi.org\/10.1007\/s11033-011-1285-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,2]]}}}