{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:15:22Z","timestamp":1791350122811,"version":"4.3.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T00:00:00Z","timestamp":1330128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s11033-012-1589-9","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T15:51:21Z","timestamp":1330098681000},"page":"7549-7558","source":"Crossref","is-referenced-by-count":72,"title":["Micro RNA responses to chronic or acute exposures to low dose ionizing radiation"],"prefix":"10.1007","volume":"39","author":[{"given":"M. Ahmad","family":"Chaudhry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romaica A.","family":"Omaruddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Kreger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia M.","family":"de Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard I.","family":"Azzam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,25]]},"reference":[{"issue":"3","key":"1589_CR1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1088\/0952-4746\/23\/3\/303","volume":"23","author":"RJ Preston","year":"2003","unstructured":"Preston RJ (2003) The LNT model is the best we can do\u2014today. J Radiol Prot 23(3):263\u2013268","journal-title":"J Radiol Prot"},{"issue":"7","key":"1589_CR2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/09553000050050954","volume":"76","author":"MP Little","year":"2000","unstructured":"Little MP, Muirhead CR (2000) Derivation of low-dose extrapolation factors from analysis of curvature in the cancer incidence dose response in Japanese atomic bomb survivors. Int J Radiat Biol 76(7):939\u2013953","journal-title":"Int J Radiat Biol"},{"issue":"7","key":"1589_CR3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3109\/09553001003734568","volume":"86","author":"MA Chaudhry","year":"2010","unstructured":"Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86(7):569\u2013583","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"1589_CR4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00411-006-0032-9","volume":"44","author":"M Tubiana","year":"2006","unstructured":"Tubiana M, Aurengo A, Averbeck D, Masse R (2006) Recent reports on the effect of low doses of ionizing radiation and its dose-effect relationship. Radiat Environ Biophys 44(4):245\u2013251","journal-title":"Radiat Environ Biophys"},{"issue":"1\u20132","key":"1589_CR5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrfmmm.2010.01.004","volume":"687","author":"D Averbeck","year":"2010","unstructured":"Averbeck D (2010) Non-targeted effects as a paradigm breaking evidence. Mutat Res 687(1\u20132):7\u201312","journal-title":"Mutat Res"},{"issue":"3","key":"1589_CR6","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/0008-5472.CAN-06-3697","volume":"67","author":"L Huang","year":"2007","unstructured":"Huang L, Kim PM, Nickoloff JA, Morgan WF (2007) Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells. Cancer Res 67(3):1099\u20131104","journal-title":"Cancer Res"},{"issue":"11","key":"1589_CR7","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/bies.20125","volume":"26","author":"JP Murnane","year":"2004","unstructured":"Murnane JP, Sabatier L (2004) Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays 26(11):1164\u20131174","journal-title":"Bioessays"},{"issue":"Suppl 1","key":"1589_CR8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1289\/ehp.98106s1277","volume":"106","author":"S Wolff","year":"1998","unstructured":"Wolff S (1998) The adaptive response in radiobiology: evolving insights and implications. Environ Health Perspect 106(Suppl 1):277\u2013283","journal-title":"Environ Health Perspect"},{"issue":"2","key":"1589_CR9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1191\/0960327104ht418oa","volume":"23","author":"EI Azzam","year":"2004","unstructured":"Azzam EI, Little JB (2004) The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol 23(2):61\u201365","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"1589_CR10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0027-5107(96)00113-3","volume":"358","author":"O Rigaud","year":"1996","unstructured":"Rigaud O, Moustacchi E (1996) Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutat Res 358(2):127\u2013134","journal-title":"Mutat Res"},{"issue":"4","key":"1589_CR11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2203\/dose-response.06-103.deToledo","volume":"4","author":"SM Toledo de","year":"2006","unstructured":"de Toledo SM, Azzam EI (2006) Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: the impact of linear energy transfer. Dose Response 4(4):291\u2013301","journal-title":"Dose Response"},{"issue":"6","key":"1589_CR12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1667\/RR0640.1","volume":"166","author":"SM Toledo de","year":"2006","unstructured":"de Toledo SM, Asaad N, Venkatachalam P, Li L, Howell RW, Spitz DR, Azzam EI (2006) Adaptive responses to low-dose\/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiat Res 166(6):849\u2013857","journal-title":"Radiat Res"},{"issue":"5","key":"1589_CR13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1667\/RR1658.1","volume":"171","author":"S Gaillard","year":"2009","unstructured":"Gaillard S, Pusset D, de Toledo SM, Fromm M, Azzam EI (2009) Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication. Radiat Res 171(5):513\u2013520","journal-title":"Radiat Res"},{"issue":"3\u20134","key":"1589_CR14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/B:CANC.0000031769.14728.bc","volume":"23","author":"DR Spitz","year":"2004","unstructured":"Spitz DR, Azzam EI, Li JJ, Gius D (2004) Metabolic oxidation\/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23(3\u20134):311\u2013322","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"1589_CR15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281\u2013297","journal-title":"Cell"},{"issue":"5670","key":"1589_CR16","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.1097434","volume":"304","author":"S Yekta","year":"2004","unstructured":"Yekta S, Shih IH, Bartel DP (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304(5670):594\u2013596","journal-title":"Science"},{"issue":"5740","key":"1589_CR17","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1115079","volume":"309","author":"RS Pillai","year":"2005","unstructured":"Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W (2005) Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 309(5740):1573\u20131576","journal-title":"Science"},{"issue":"7027","key":"1589_CR18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"LP Lim","year":"2005","unstructured":"Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433(7027):769\u2013773","journal-title":"Nature"},{"issue":"11","key":"1589_CR19","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","volume":"2","author":"B John","year":"2004","unstructured":"John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS (2004) Human MicroRNA targets. PLoS Biol 2(11):e363","journal-title":"PLoS Biol"},{"issue":"1","key":"1589_CR20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/cbr.2008.0513","volume":"24","author":"MA Chaudhry","year":"2009","unstructured":"Chaudhry MA (2009) Real-time PCR analysis of micro-RNA expression in ionizing radiation-treated cells. Cancer Biother Radiopharm 24(1):49\u201356","journal-title":"Cancer Biother Radiopharm"},{"key":"1589_CR21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3109\/09553001003734568","volume":"86","author":"MA Chaudhry","year":"2010","unstructured":"Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86:569\u2013583","journal-title":"Int J Radiat Biol"},{"issue":"9","key":"1589_CR22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1089\/dna.2009.0978","volume":"29","author":"MA Chaudhry","year":"2010","unstructured":"Chaudhry MA, Sachdeva H, Omaruddin RA (2010) Radiation-induced Micro-RNA modulation in glioblastoma cells differing in DNA-repair pathways. DNA Cell Biol 29(9):553\u2013561","journal-title":"DNA Cell Biol"},{"key":"1589_CR23","unstructured":"Goddu SM, Howell RW, Rao DV (2001) Method and means for variably attenuating radiation. United States Patent US 6,201,852 B1"},{"key":"1589_CR24","first-page":"727","volume":"38","author":"RW Howell","year":"1997","unstructured":"Howell RW, Goddu SM, Rao DV (1997) Design and performance characteristics of an experimental Cs-137 irradiator to simulate internal radionuclide dose rate patterns. J Nucl Med 38:727\u2013731","journal-title":"J Nucl Med"},{"issue":"4","key":"1589_CR25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"3","key":"1589_CR26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0301-472X(98)00053-8","volume":"27","author":"J Bagley","year":"1999","unstructured":"Bagley J, Rosenzweig M, Marks DF, Pykett MJ (1999) Extended culture of multipotent hematopoietic progenitors without cytokine augmentation in a novel three-dimensional device. Exp Hematol 27(3):496\u2013504","journal-title":"Exp Hematol"},{"issue":"7","key":"1589_CR27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/77288","volume":"18","author":"MC Poznansky","year":"2000","unstructured":"Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT (2000) Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat Biotechnol 18(7):729\u2013734","journal-title":"Nat Biotechnol"},{"issue":"5","key":"1589_CR28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","volume":"120","author":"SM Johnson","year":"2005","unstructured":"Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120(5):635\u2013647","journal-title":"Cell"},{"issue":"11","key":"1589_CR29","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1158\/0008-5472.CAN-04-0637","volume":"64","author":"J Takamizawa","year":"2004","unstructured":"Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T (2004) Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64(11):3753\u20133756","journal-title":"Cancer Res"},{"issue":"3","key":"1589_CR30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1634\/theoncologist.4-3-263","volume":"4","author":"DS Goodsell","year":"1999","unstructured":"Goodsell DS (1999) The molecular perspective: the ras oncogene. Oncologist 4(3):263\u2013264","journal-title":"Oncologist"},{"key":"1589_CR31","first-page":"245","volume":"3","author":"JRE Yaguang Xi","year":"2007","unstructured":"Yaguang Xi JRE, Jingfang Ju (2007) Investigation of miRNA Biology by bioinformatic tools and impact of miRNAs in colorectal cancer\u2014regulatory relationship of c-Myc and p53 with miRNAs. Cancer Inform 3:245\u2013253","journal-title":"Cancer Inform"},{"issue":"7043","key":"1589_CR32","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM (2005) A microRNA polycistron as a potential human oncogene. Nature 435(7043):828\u2013833","journal-title":"Nature"},{"issue":"3","key":"1589_CR33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(02)00738-9","volume":"109","author":"S Pelengaris","year":"2002","unstructured":"Pelengaris S, Khan M, Evan GI (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109(3):321\u2013334","journal-title":"Cell"},{"issue":"39","key":"1589_CR34","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1073\/pnas.0506654102","volume":"102","author":"A Cimmino","year":"2005","unstructured":"Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102(39):13944\u201313949","journal-title":"Proc Natl Acad Sci USA"},{"issue":"24","key":"1589_CR35","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","volume":"99","author":"GA Calin","year":"2002","unstructured":"Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99(24):15524\u201315529","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2\u20133","key":"1589_CR36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/em.20091","volume":"45","author":"GS Akerman","year":"2005","unstructured":"Akerman GS, Rosenzweig BA, Domon OE, Tsai CA, Bishop ME, McGarrity LJ, Macgregor JT, Sistare FD, Chen JJ, Morris SM (2005) Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ Mol Mutagen 45(2\u20133):188\u2013205","journal-title":"Environ Mol Mutagen"},{"issue":"11","key":"1589_CR37","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.4161\/cbt.7.11.6722","volume":"7","author":"EY Chung","year":"2008","unstructured":"Chung EY, Dews M, Cozma D, Yu D, Wentzel EA, Chang TC, Schelter JM, Cleary MA, Mendell JT, Thomas-Tikhonenko A (2008) c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster. Cancer Biol Ther 7(11):1758\u20131764","journal-title":"Cancer Biol Ther"},{"issue":"10","key":"1589_CR38","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1073\/pnas.0500613102","volume":"102","author":"PS Eis","year":"2005","unstructured":"Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 102(10):3627\u20133632","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Database issue","key":"1589_CR39","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkj093","volume":"34","author":"P Shahi","year":"2006","unstructured":"Shahi P, Loukianiouk S, Bohne-Lang A, Kenzelmann M, Kuffer S, Maertens S, Eils R, Grone HJ, Gretz N, Brors B (2006) Argonaute\u2014a database for gene regulation by mammalian microRNAs. Nucleic Acids Res 34(Database issue):D115\u2013D118","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1589_CR40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","volume":"9","author":"N Yanaihara","year":"2006","unstructured":"Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9(3):189\u2013198","journal-title":"Cancer Cell"},{"issue":"12","key":"1589_CR41","first-page":"882","volume":"1","author":"MZ Michael","year":"2003","unstructured":"Michael MZ, O\u2019Connor SM, van Holst Pellekaan NG, Young GP, James RJ (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1(12):882\u2013891","journal-title":"Mol Cancer Res"},{"issue":"14","key":"1589_CR42","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-05-0137","volume":"65","author":"JA Chan","year":"2005","unstructured":"Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65(14):6029\u20136033","journal-title":"Cancer Res"},{"issue":"4","key":"1589_CR43","first-page":"863","volume":"22","author":"HJ Cha","year":"2009","unstructured":"Cha HJ, Seong KM, Bae S, Jung JH, Kim CS, Yang KH, Jin YW, An S (2009) Identification of specific microRNAs responding to low and high dose gamma-irradiation in the human lymphoblast line IM9. Oncol Rep 22(4):863\u2013868","journal-title":"Oncol Rep"},{"issue":"15","key":"1589_CR44","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","volume":"27","author":"IA Asangani","year":"2008","unstructured":"Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27(15):2128\u20132136","journal-title":"Oncogene"},{"issue":"2","key":"1589_CR45","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1074\/jbc.M707224200","volume":"283","author":"LB Frankel","year":"2008","unstructured":"Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283(2):1026\u20131033","journal-title":"J Biol Chem"},{"key":"1589_CR46","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1038\/onc.2008.72","volume":"27","author":"Z Lu","year":"2008","unstructured":"Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y (2008) MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27:4373\u20134379","journal-title":"Oncogene"},{"issue":"19","key":"1589_CR47","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1074\/jbc.M611393200","volume":"282","author":"S Zhu","year":"2007","unstructured":"Zhu S, Si ML, Wu H, Mo YY (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282(19):14328\u201314336","journal-title":"J Biol Chem"},{"issue":"2","key":"1589_CR48","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2007.05.022","volume":"133","author":"F Meng","year":"2007","unstructured":"Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133(2):647\u2013658","journal-title":"Gastroenterology"},{"key":"1589_CR49","doi-asserted-by":"crossref","unstructured":"Sayed D, Rane S, Lypowy J, He M, Chen IY, Vashistha H, Yan L, Malhotra A, Vatner D, Abdellatif M (2008) MicroRNA-21 targets sprouty2 and promotes cellular outgrowths. Mol Biol Cell","DOI":"10.1091\/mbc.e08-02-0159"},{"issue":"1","key":"1589_CR50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1667\/RR3354","volume":"164","author":"LH Ding","year":"2005","unstructured":"Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ (2005) Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 164(1):17\u201326","journal-title":"Radiat Res"},{"issue":"4","key":"1589_CR51","first-page":"607","volume":"19","author":"XH Long","year":"2007","unstructured":"Long XH, Zhao ZQ, He XP, Wang HP, Xu QZ, An J, Bai B, Sui JL, Zhou PK (2007) Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells. Int J Mol Med 19(4):607\u2013615","journal-title":"Int J Mol Med"},{"issue":"22","key":"1589_CR52","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.1158\/0008-5472.CAN-05-2015","volume":"65","author":"A Fujimori","year":"2005","unstructured":"Fujimori A, Okayasu R, Ishihara H, Yoshida S, Eguchi-Kasai K, Nojima K, Ebisawa S, Takahashi S (2005) Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts. Cancer Res 65(22):10159\u201310163","journal-title":"Cancer Res"},{"issue":"6","key":"1589_CR53","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1667\/RR0487.1","volume":"168","author":"AL Fachin","year":"2007","unstructured":"Fachin AL, Mello SS, Sandrin-Garcia P, Junta CM, Donadi EA, Passos GA, Sakamoto-Hojo ET (2007) Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. Radiat Res 168(6):650\u2013665","journal-title":"Radiat Res"},{"issue":"6","key":"1589_CR54","first-page":"445","volume":"1","author":"SA Amundson","year":"2003","unstructured":"Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM, Fornace AJ Jr (2003) Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 1(6):445\u2013452","journal-title":"Mol Cancer Res"},{"issue":"3","key":"1589_CR55","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1667\/RR3223","volume":"162","author":"T Sugihara","year":"2004","unstructured":"Sugihara T, Magae J, Wadhwa R, Kaul SC, Kawakami Y, Matsumoto T, Tanaka K (2004) Dose and dose-rate effects of low-dose ionizing radiation on activation of Trp53 in immortalized murine cells. Radiat Res 162(3):296\u2013307","journal-title":"Radiat Res"},{"issue":"3","key":"1589_CR56","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/09553000902748609","volume":"85","author":"DS Gridley","year":"2009","unstructured":"Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM (2009) Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression. Int J Radiat Biol 85(3):250\u2013261","journal-title":"Int J Radiat Biol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-012-1589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-012-1589-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-012-1589-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T01:37:56Z","timestamp":1593740276000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-012-1589-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,25]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1589"],"URL":"https:\/\/doi.org\/10.1007\/s11033-012-1589-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,25]]}}}