{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:25:44Z","timestamp":1761863144557},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T00:00:00Z","timestamp":1356739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s11033-012-2477-z","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T12:21:07Z","timestamp":1356697267000},"page":"3995-4000","source":"Crossref","is-referenced-by-count":13,"title":["Expression level of histone deacetylase 2 correlates with occurring of chronic obstructive pulmonary diseases"],"prefix":"10.1007","volume":"40","author":[{"given":"Yiqing","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dedong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangai","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,12,29]]},"reference":[{"key":"2477_CR1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1056\/NEJM200007273430407","volume":"343","author":"PJ Barnes","year":"2000","unstructured":"Barnes PJ (2000) Chronic obstructive pulmonary disease. New Engl J Med 343:269\u2013280","journal-title":"New Engl J Med"},{"key":"2477_CR2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","volume":"176","author":"KF Rabe","year":"2007","unstructured":"Rabe KF, Hurd S, Anzueto A et al (2007) Global strategy for the diagnosis, management, and prevention of COPD. Am J Respir Crit Care Med 176:532\u2013555","journal-title":"Am J Respir Crit Care Med"},{"key":"2477_CR3","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1371\/journal.pmed.0040112","volume":"4","author":"PJ Barnes","year":"2007","unstructured":"Barnes PJ (2007) Chronic obstructive pulmonary disease: a growing but neglected epidemic. PLoS Med 4:e112","journal-title":"PLoS Med"},{"key":"2477_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1615\/CritRevImmunol.v31.i3.40","volume":"31","author":"AM Grabiec","year":"2011","unstructured":"Grabiec AM, Tak PP, Reedquist KA (2011) Function of histone deacetylase inhibitors in inflammation. Crit Rev Immunol 31:233\u2013263","journal-title":"Crit Rev Immunol"},{"key":"2477_CR5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.arbres.2010.12.003","volume":"47","author":"AL Kersul","year":"2011","unstructured":"Kersul AL, Iglesias A, R\u00edos \u00c1 et al (2011) Molecular mechanisms of inflammation during exacerbations of chronic obstructive pulmonary disease. Arch Bronconeumol 47:176\u2013183","journal-title":"Arch Bronconeumol"},{"key":"2477_CR6","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1038\/sj.onc.1204323","volume":"20","author":"FD Urnov","year":"2001","unstructured":"Urnov FD, Wolffe AP (2001) Chromatin remodeling and transcriptional activation: the cast (in order of appearance). Oncogene 20:2991\u20133006","journal-title":"Oncogene"},{"key":"2477_CR7","first-page":"197","volume":"10","author":"F Blanchard","year":"2005","unstructured":"Blanchard F, Chipoy C (2005) Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases? Drug Discov 10:197\u2013204","journal-title":"Drug Discov"},{"key":"2477_CR8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc1779","volume":"6","author":"S Minucci","year":"2006","unstructured":"Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6:38\u201351","journal-title":"Nat Rev Cancer"},{"key":"2477_CR9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","volume":"32","author":"MR Shakespear","year":"2011","unstructured":"Shakespear MR, Halili MA, Irvine KM, Fairlie DP, Sweet MJ (2011) Histone deacetylases as regulators of inflammation and immunity. Trends Immunol 32:335\u2013343","journal-title":"Trends Immunol"},{"key":"2477_CR10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2119\/molmed.2011.00030","volume":"17","author":"J Vojinovic","year":"2011","unstructured":"Vojinovic J, Damjanov N (2011) HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritis. Mol Med 17:397\u2013403","journal-title":"Mol Med"},{"key":"2477_CR11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/156800910791054149","volume":"10","author":"S M\u00fcller","year":"2010","unstructured":"M\u00fcller S, Kr\u00e4mer OH (2010) Inhibitors of HDACs\u2013effective drugs against cancer? Curr Cancer Drug Targets 10:210\u2013228","journal-title":"Curr Cancer Drug Targets"},{"key":"2477_CR12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","volume":"363","author":"MA Glozak","year":"2005","unstructured":"Glozak MA, Sengupta N, Zhang X, Seto E (2005) Acetylation and deacetylation of non-histone proteins. Gene 363:15\u201323","journal-title":"Gene"},{"key":"2477_CR13","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/cdd.2011.71","volume":"18","author":"D Li","year":"2011","unstructured":"Li D, Marchenko ND, Moll UM (2011) SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ 18:1904\u20131913","journal-title":"Cell Death Differ"},{"key":"2477_CR14","doi-asserted-by":"crossref","first-page":"e26156","DOI":"10.1371\/journal.pone.0026156","volume":"6","author":"N Bansal","year":"2011","unstructured":"Bansal N, Kadamb R, Mittal S, Vig L, Sharma R, Dwarakanath BS, Saluja D (2011) Tumor suppressor protein p53 recruits human Sin3B\/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PLoS ONE 6:e26156","journal-title":"PLoS ONE"},{"key":"2477_CR15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nn.2780","volume":"14","author":"Y Chen","year":"2011","unstructured":"Chen Y, Wang H, Yoon SO et al (2011) HDAC-mediated deacetylation of NF-\u03baB is critical for Schwann cell myelination. Nat Neurosci 14:437\u2013441","journal-title":"Nat Neurosci"},{"key":"2477_CR16","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1158\/1541-7786.MCR-08-0548","volume":"7","author":"P Bendinelli","year":"2009","unstructured":"Bendinelli P, Matteucci E, Maroni P, Desiderio MA (2009) NF-kappaB activation, dependent on acetylation\/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells. Mol Cancer Res 7:1328\u20131341","journal-title":"Mol Cancer Res"},{"key":"2477_CR17","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.bbagen.2011.08.015","volume":"1810","author":"YF Hsu","year":"2011","unstructured":"Hsu YF, Sheu JR, Lin CH, Chen WC, Hsiao G, Ou G, Chiu PT, Hsu MJ (2011) MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. Biochim Biophys Acta 1810:1160\u20131169","journal-title":"Biochim Biophys Acta"},{"key":"2477_CR18","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","volume":"350","author":"JC Hogg","year":"2004","unstructured":"Hogg JC, Chu F, Utokaparch S et al (2004) The nature of smallairway obstruction in chronic obstructive pulmonary disease. New Engl J Med 350:2645\u20132653","journal-title":"New Engl J Med"},{"key":"2477_CR19","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1248\/bpb.34.1432","volume":"34","author":"MK Ha","year":"2011","unstructured":"Ha MK, Song YH, Jeong SJ et al (2011) Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes. Biol Pharm Bull 34:1432\u20131437","journal-title":"Biol Pharm Bull"},{"key":"2477_CR20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1183\/09031936.03.00093703","volume":"22","author":"IS Patel","year":"2003","unstructured":"Patel IS, Roberts NJ, Lloyd-Owen SJ, Sapsford RJ, Wedzicha JA (2003) Airway epithelial inflammatory responses and clinical parameters in COPD. Eur Respir J 22:94\u201399","journal-title":"Eur Respir J"},{"key":"2477_CR21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(04)16900-6","volume":"364","author":"JC Hogg","year":"2004","unstructured":"Hogg JC (2004) Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364:709\u2013721","journal-title":"Lancet"},{"key":"2477_CR22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1183\/09031936.05.00117504","volume":"25","author":"PJ Barnes","year":"2005","unstructured":"Barnes PJ, Adcock IM, Ito K (2005) Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 25:552\u2013563","journal-title":"Eur Respir J"},{"key":"2477_CR23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ Ruijter de","year":"2003","unstructured":"de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737\u2013749","journal-title":"Biochem J"},{"key":"2477_CR24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb05964.x","volume":"983","author":"S Thiagalingam","year":"2003","unstructured":"Thiagalingam S, Cheng KH, Lee HJ, Mineva N, Thiagalingam A, Ponte JF (2003) Histone deacetylases: unique players in shaping the epigenetic histone code. Ann N Y Acad Sci 983:84\u2013100","journal-title":"Ann N Y Acad Sci"},{"key":"2477_CR25","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1016\/j.bmc.2010.08.045","volume":"18","author":"SV Weerasinghe","year":"2010","unstructured":"Weerasinghe SV, Wambua M, Pflum MK (2010) A histone deacetylase-dependent screen in yeast. Bioorg Med Chem 18:7586\u20137592","journal-title":"Bioorg Med Chem"},{"key":"2477_CR26","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.0909169107","volume":"107","author":"S Ehrentraut","year":"2010","unstructured":"Ehrentraut S, Weber JM, Dybowski JN, Hoffmann D, Ehrenhofer-Murray AE (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. Proc Natl Acad Sci U S A 107:5522\u20135527","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2477_CR27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrm2346","volume":"9","author":"XJ Yang","year":"2008","unstructured":"Yang XJ, Seto E (2008) The Rpd3\/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9:206\u2013218","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2477_CR28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1534\/genetics.111.130781","volume":"189","author":"JS Choy","year":"2011","unstructured":"Choy JS, Acu\u00f1a R, Au WC, Basrai MA (2011) A role for histone H4K16 hypoacetylation in Saccharomyces cerevisiae kinetochore function. Genetics 189:11\u201321","journal-title":"Genetics"},{"key":"2477_CR29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1165\/rcmb.2004-0006OC","volume":"31","author":"JA Marwick","year":"2004","unstructured":"Marwick JA, Kirkham PA, Stevenson CS et al (2004) Cigarette smoke alters chromatin remodelling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol 31:633\u2013642","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2477_CR30","first-page":"1100","volume":"15","author":"K Ito","year":"2001","unstructured":"Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM (2001) Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 15:1100\u20131102","journal-title":"FASEB J"},{"key":"2477_CR31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/cgt.2011.11","volume":"18","author":"DR Kim","year":"2011","unstructured":"Kim DR, Park MY, Lee CS et al (2011) Combination of vorinostat and adenovirus-TRAIL exhibits a synergistic antitumor effect by increasing transduction and transcription of TRAIL in lung cancer cells. Cancer Gene Ther 18:467\u2013477","journal-title":"Cancer Gene Ther"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-012-2477-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-012-2477-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-012-2477-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T23:16:11Z","timestamp":1559344571000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-012-2477-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,29]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["2477"],"URL":"https:\/\/doi.org\/10.1007\/s11033-012-2477-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,29]]}}}